psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I30	R:R:P27	5.08	No	No	0	6	4
2	R:R:E28	R:R:F32	12.83	No	Yes	3	4	4
3	R:R:E28	R:R:K77	6.75	No	Yes	3	4	6
4	R:R:F31	R:R:I34	5.02	Yes	No	0	5	6
5	R:R:F31	R:R:K77	13.65	Yes	Yes	0	5	6
6	R:R:F31	R:R:M263	12.44	Yes	No	0	5	4
7	R:R:F32	R:R:K77	9.93	Yes	Yes	3	4	6
8	R:R:F32	R:R:I78	7.54	Yes	No	0	4	5
9	R:R:S35	R:R:S74	3.26	No	No	0	6	8
10	R:R:K77	R:R:S35	6.12	Yes	No	0	6	6
11	R:R:G38	R:R:V37	3.68	No	No	0	7	4
12	R:R:G38	R:R:V270	3.68	No	No	0	7	6
13	R:R:M71	R:R:V39	6.09	No	No	0	7	6
14	R:R:S74	R:R:V39	3.23	No	No	0	8	6
15	R:R:E41	R:R:V270	4.28	No	No	0	7	6
16	R:R:E41	R:R:P273	7.86	No	Yes	0	7	9
17	R:R:E41	R:R:F274	3.5	No	No	0	7	6
18	R:R:A67	R:R:N42	4.69	No	Yes	0	9	9
19	R:R:D70	R:R:N42	12.12	Yes	Yes	4	9	9
20	R:R:M71	R:R:N42	4.21	No	Yes	0	7	9
21	R:R:N42	R:R:P273	8.15	Yes	Yes	4	9	9
22	R:R:F278	R:R:V45	6.55	No	No	0	6	9
23	R:R:F50	R:R:V49	11.8	No	No	0	3	8
24	R:R:F50	R:R:F61	4.29	No	No	0	3	4
25	R:R:A286	R:R:N52	4.69	No	No	0	8	6
26	R:R:L55	R:R:N54	9.61	No	No	0	9	6
27	R:R:L55	R:R:Y60	10.55	No	Yes	1	9	8
28	R:R:E282	R:R:L55	5.3	Yes	No	1	6	9
29	R:R:F61	R:R:Q56	3.51	No	No	0	4	8
30	R:R:P58	R:R:T147	10.49	No	No	0	6	7
31	R:R:M59	R:R:Y60	13.17	No	Yes	0	8	8
32	R:R:S280	R:R:Y60	7.63	No	Yes	1	8	8
33	R:R:E282	R:R:Y60	6.73	Yes	Yes	1	6	8
34	R:R:L283	R:R:Y60	4.69	Yes	Yes	1	8	8
35	R:R:F61	R:R:M144	9.95	No	No	0	4	2
36	R:R:F62	R:R:V123	7.87	Yes	No	0	8	6
37	R:R:D127	R:R:F62	7.17	No	Yes	0	9	8
38	R:R:F62	R:R:L151	3.65	Yes	No	0	8	6
39	R:R:A277	R:R:I63	6.5	No	No	0	8	8
40	R:R:L151	R:R:S65	6.01	No	No	0	6	9
41	R:R:S65	R:R:W155	6.18	No	Yes	0	9	9
42	R:R:D70	R:R:L66	5.43	Yes	Yes	0	9	9
43	R:R:L66	R:R:S120	6.01	Yes	No	0	9	7
44	R:R:L121	R:R:L66	4.15	No	Yes	0	8	9
45	R:R:L66	R:R:Y276	3.52	Yes	Yes	0	9	9
46	R:R:I68	R:R:W155	7.05	No	Yes	0	6	9
47	R:R:S117	R:R:S69	4.89	No	No	0	9	8
48	R:R:S69	R:R:W155	3.71	No	Yes	0	8	9
49	R:R:A269	R:R:D70	4.63	No	Yes	0	9	9
50	R:R:D272	R:R:D70	5.32	No	Yes	0	9	9
51	R:R:D70	R:R:P273	6.44	Yes	Yes	4	9	9
52	R:R:G73	R:R:S113	3.71	No	No	0	7	7
53	R:R:I78	R:R:L75	4.28	No	No	0	5	4
54	R:R:D107	R:R:Y76	4.6	No	Yes	0	4	5
55	R:R:L109	R:R:Y76	3.52	No	Yes	0	5	5
56	R:R:F110	R:R:Y76	23.73	Yes	Yes	0	5	5
57	R:R:M266	R:R:Y76	4.79	No	Yes	0	6	5
58	R:R:K77	R:R:M266	8.64	Yes	No	0	6	6
59	R:R:A102	R:R:I105	3.25	No	No	0	3	4
60	R:R:I105	R:R:S108	6.19	No	No	0	4	5
61	R:R:L109	R:R:L112	4.15	No	No	0	5	5
62	R:R:F110	R:R:V111	5.24	Yes	No	0	5	4
63	R:R:F110	R:R:L114	6.09	Yes	Yes	0	5	5
64	R:R:F110	R:R:F235	16.08	Yes	No	0	5	6
65	R:R:M165	R:R:V111	6.09	No	No	0	4	4
66	R:R:G162	R:R:L112	3.42	No	No	0	6	5
67	R:R:L114	R:R:W232	9.11	Yes	Yes	2	5	8
68	R:R:I265	R:R:L114	4.28	Yes	Yes	2	7	5
69	R:R:C158	R:R:L115	3.17	No	No	0	7	5
70	R:R:L115	R:R:L181	4.15	No	No	0	5	4
71	R:R:C158	R:R:G116	3.92	No	No	0	7	7
72	R:R:S117	R:R:W232	6.18	No	Yes	0	9	8
73	R:R:I118	R:R:L181	5.71	Yes	No	0	7	4
74	R:R:I118	R:R:M185	5.83	Yes	Yes	2	7	6
75	R:R:F228	R:R:I118	5.02	Yes	Yes	2	9	7
76	R:R:I118	R:R:W232	10.57	Yes	Yes	2	7	8
77	R:R:C158	R:R:F119	5.59	No	No	0	7	5
78	R:R:M185	R:R:S122	4.6	Yes	No	2	6	6
79	R:R:F188	R:R:S122	7.93	Yes	No	2	5	6
80	R:R:V123	R:R:V150	3.21	No	No	0	6	5
81	R:R:I124	R:R:R128	3.76	No	No	0	8	9
82	R:R:I124	R:R:Y276	10.88	No	Yes	0	8	9
83	R:R:D127	R:R:Y138	5.75	No	Yes	0	9	8
84	R:R:R128	R:R:Y193	7.2	No	Yes	0	9	9
85	R:R:F133	R:R:Y129	11.35	Yes	No	6	6	8
86	R:R:L192	R:R:Y129	11.72	No	No	0	7	8
87	R:R:H195	R:R:Y129	7.62	No	No	6	5	8
88	R:R:H134	R:R:I130	5.3	No	No	0	5	6
89	R:R:I130	R:R:Y138	6.04	No	Yes	0	6	8
90	R:R:T131	R:R:Y138	8.74	No	Yes	0	8	8
91	R:R:F133	R:R:I132	3.77	Yes	No	0	6	9
92	R:R:I132	R:R:M196	7.29	No	No	0	9	9
93	R:R:F133	R:R:H195	14.71	Yes	No	6	6	5
94	R:R:F133	R:R:L199	7.31	Yes	No	0	6	6
95	R:R:H139	R:R:Y138	4.36	No	Yes	0	5	8
96	R:R:V142	R:R:Y138	7.57	No	Yes	0	7	8
97	R:R:M144	R:R:T147	6.02	No	No	0	2	7
98	R:R:M144	R:R:V148	4.56	No	No	0	2	1
99	R:R:R145	R:R:R146	13.86	No	No	7	4	7
100	R:R:F157	R:R:V153	7.87	No	No	0	3	3
101	R:R:I154	R:R:W155	4.7	No	Yes	0	6	9
102	R:R:G160	R:R:I163	3.53	No	No	0	2	4
103	R:R:I167	R:R:T164	9.12	No	No	0	5	4
104	R:R:S169	R:R:V166	3.23	No	No	0	6	4
105	R:R:F168	R:R:I167	8.79	Yes	No	0	4	5
106	R:R:F168	R:R:H171	14.71	Yes	No	0	4	3
107	R:R:F168	R:R:P173	4.33	Yes	No	0	4	3
108	R:R:P173	R:R:V172	3.53	No	No	0	3	3
109	R:R:V175	R:R:V239	4.81	No	No	0	4	5
110	R:R:T243	R:R:V175	6.35	No	No	0	4	4
111	R:R:F178	R:R:F235	5.36	No	No	0	4	6
112	R:R:F178	R:R:V236	3.93	No	No	0	4	5
113	R:R:F178	R:R:V239	5.24	No	No	0	4	5
114	R:R:L240	R:R:T179	8.84	No	No	0	5	4
115	R:R:L184	R:R:S180	4.5	No	No	0	4	3
116	R:R:F182	R:R:L186	8.53	Yes	No	0	6	6
117	R:R:F182	R:R:F228	6.43	Yes	Yes	0	6	9
118	R:R:F182	R:R:I229	5.02	Yes	No	0	6	6
119	R:R:A233	R:R:F182	5.55	No	Yes	0	5	6
120	R:R:F182	R:R:V236	9.18	Yes	No	0	6	5
121	R:R:L184	R:R:M185	7.07	No	Yes	0	4	6
122	R:R:F188	R:R:M185	4.98	Yes	Yes	2	5	6
123	R:R:F188	R:R:L192	7.31	Yes	No	0	5	7
124	R:R:I189	R:R:Y193	4.84	No	Yes	0	8	9
125	R:R:F228	R:R:I189	3.77	Yes	No	0	9	8
126	R:R:L190	R:R:L225	4.15	No	No	0	5	7
127	R:R:L221	R:R:Y193	5.86	No	Yes	0	7	9
128	R:R:L224	R:R:Y193	3.52	No	Yes	5	8	9
129	R:R:L225	R:R:Y193	7.03	No	Yes	0	7	9
130	R:R:Y193	R:R:Y276	8.94	Yes	Yes	5	9	9
131	R:R:F197	R:R:N214	6.04	No	Yes	0	6	6
132	R:R:F197	R:R:L221	3.65	No	No	0	6	7
133	R:R:H203	R:R:L199	5.14	No	No	0	8	6
134	R:R:R201	R:R:R205	4.26	No	No	0	6	4
135	R:R:N214	R:R:T204	7.31	Yes	No	0	6	5
136	R:R:A213	R:R:R205	4.15	No	No	0	5	4
137	R:R:G217	R:R:N214	5.09	No	Yes	0	7	6
138	R:R:I275	R:R:L224	4.28	Yes	No	0	8	8
139	R:R:L224	R:R:Y276	12.89	No	Yes	5	8	9
140	R:R:F228	R:R:W232	8.02	Yes	Yes	2	9	8
141	R:R:F230	R:R:I229	5.02	No	No	0	4	6
142	R:R:C231	R:R:N268	11.02	No	No	0	8	9
143	R:R:I265	R:R:W232	8.22	Yes	Yes	2	7	8
144	R:R:N268	R:R:W232	7.91	No	Yes	0	9	8
145	R:R:N261	R:R:P234	4.89	No	No	0	5	9
146	R:R:F235	R:R:F258	3.22	No	No	0	6	4
147	R:R:H238	R:R:M255	10.51	No	No	0	5	1
148	R:R:H238	R:R:N261	14.03	No	No	0	5	5
149	R:R:F244	R:R:L240	3.65	No	No	0	4	5
150	R:R:C245	R:R:L241	6.35	No	No	0	4	4
151	R:R:L241	R:R:M255	4.24	No	No	0	4	1
152	R:R:M242	R:R:M255	8.66	No	No	0	4	1
153	R:R:C245	R:R:C251	7.28	No	No	0	4	4
154	R:R:N248	R:R:P249	8.15	No	No	0	4	2
155	R:R:N248	R:R:Y250	3.49	No	No	0	4	4
156	R:R:C251	R:R:N248	6.3	No	No	0	4	4
157	R:R:L257	R:R:V260	4.47	No	No	0	5	3
158	R:R:C267	R:R:L264	3.17	No	No	0	4	7
159	R:R:I265	R:R:M266	4.37	Yes	No	0	7	6
160	R:R:D272	R:R:N268	10.77	No	No	0	9	9
161	R:R:F274	R:R:I275	5.02	No	Yes	0	6	8
162	R:R:I275	R:R:R279	6.26	Yes	No	0	8	8
163	R:R:F278	R:R:L283	4.87	No	Yes	0	6	8
164	R:R:P281	R:R:S280	5.34	No	No	1	5	8
165	R:R:E282	R:R:S280	8.62	Yes	No	1	6	8
166	R:R:E282	R:R:P281	7.86	Yes	No	1	6	5
167	R:R:I141	R:R:S140	3.1	No	No	0	5	5
168	R:R:I271	R:R:V227	3.07	No	No	0	7	6
169	R:R:I30	R:R:T33	3.04	No	No	0	6	3
170	R:R:M165	R:R:V166	3.04	No	No	0	4	4
171	R:R:I223	R:R:T222	3.04	No	No	0	7	6
172	R:R:L257	R:R:S256	3	No	No	0	5	1
173	R:R:L186	R:R:V187	2.98	No	No	0	6	4
174	R:R:L221	R:R:V194	2.98	No	No	0	7	3
175	R:R:Y250	R:R:Y254	2.98	No	No	0	4	3
176	R:R:N261	R:R:V260	2.96	No	No	0	5	3
177	R:R:I223	R:R:I275	2.94	No	Yes	0	7	8
178	R:R:F182	R:R:P183	2.89	Yes	No	0	6	4
179	R:R:I36	R:R:L40	2.85	No	No	0	4	4
180	R:R:I106	R:R:L79	2.85	No	No	0	5	6
181	R:R:D107	R:R:I106	2.8	No	No	0	4	5
182	R:R:A126	R:R:F188	2.77	No	Yes	0	6	5
183	R:R:K53	R:R:Q56	2.71	No	No	0	5	8
184	R:R:A57	R:R:Y60	2.67	No	Yes	0	7	8
185	R:R:A125	R:R:Y193	2.67	No	Yes	0	8	9
186	R:R:F62	R:R:T147	2.59	Yes	No	0	8	7
187	R:R:L198	R:R:R201	2.43	No	No	0	3	6
188	R:R:F32	R:R:N81	2.42	Yes	No	0	4	5
189	R:R:I63	R:R:Y60	2.42	No	Yes	0	8	8
190	R:R:C245	R:R:P246	1.88	No	No	0	4	1
191	R:R:A57	R:R:P58	1.87	No	No	0	7	6
192	R:R:A233	R:R:P234	1.87	No	No	0	5	9
193	R:R:A277	R:R:P273	1.87	No	Yes	0	8	9
194	R:R:G160	R:R:T159	1.82	No	No	0	2	3
195	R:R:G217	R:R:T220	1.82	No	No	0	7	9
196	R:R:A286	R:R:A48	1.79	No	No	1	8	8
197	R:R:G226	R:R:I229	1.76	No	No	0	6	6
198	R:R:G262	R:R:I265	1.76	No	Yes	0	4	7
199	R:R:P173	R:R:T177	1.75	No	No	0	3	4
200	R:R:C231	R:R:V227	1.71	No	No	0	8	6
201	R:R:V149	R:R:V150	1.6	No	No	0	3	5
202	R:R:C64	R:R:L46	1.59	No	No	0	6	8
203	R:R:T152	R:R:V148	1.59	No	No	0	3	1
204	R:R:T152	R:R:V149	1.59	No	No	0	3	3
205	R:R:T152	R:R:V153	1.59	No	No	0	3	3
206	R:R:T179	R:R:V239	1.59	No	No	0	4	5
207	R:R:A67	R:R:L46	1.58	No	No	0	9	8
208	R:R:A48	R:R:L283	1.58	No	Yes	1	8	8
209	R:R:A286	R:R:L283	1.58	No	Yes	1	8	8
210	R:R:E29	R:R:P27	1.57	No	No	0	4	4
211	R:R:A200	R:R:N214	1.56	No	Yes	0	8	6
212	R:R:I44	R:R:V45	1.54	No	No	0	7	9
213	R:R:I141	R:R:V142	1.54	No	No	0	5	7
214	R:R:I176	R:R:V175	1.54	No	No	0	3	4
215	R:R:K206	R:R:S202	1.53	No	No	0	5	4
216	R:R:M165	R:R:T174	1.51	No	No	0	4	5
217	R:R:L72	R:R:S113	1.5	No	No	0	6	7
218	R:R:L109	R:R:S108	1.5	No	No	0	5	5
219	R:R:L114	R:R:S113	1.5	Yes	No	0	5	7
220	R:R:L198	R:R:V194	1.49	No	No	0	3	3
221	R:R:L115	R:R:T161	1.47	No	No	0	5	5
222	R:R:I219	R:R:K216	1.45	No	No	0	6	8
223	R:R:C267	R:R:F31	1.4	No	Yes	0	4	5
224	R:R:K51	R:R:N52	1.4	No	No	0	5	6
225	R:R:A218	R:R:F197	1.39	No	No	0	8	6
226	R:R:L40	R:R:L43	1.38	No	No	0	4	4
227	R:R:E80	R:R:I106	1.37	No	No	0	5	5
228	R:R:C253	R:R:Y250	1.34	No	No	0	3	4
229	R:R:R146	R:R:V149	1.31	No	No	0	7	3
230	R:R:F168	R:R:T174	1.3	Yes	No	0	4	5
231	R:R:R145	R:R:T143	1.29	No	No	7	4	8
232	R:R:R146	R:R:T143	1.29	No	No	7	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F31	8.1275	4	0	5
2	R:R:F32	8.18	4	3	4
3	R:R:N42	7.2925	4	4	9
4	R:R:Y60	6.83714	7	1	8
5	R:R:F62	5.32	4	0	8
6	R:R:L66	4.7775	4	0	9
7	R:R:D70	6.788	5	4	9
8	R:R:Y76	9.16	4	0	5
9	R:R:K77	9.018	5	3	6
10	R:R:F110	12.785	4	0	5
11	R:R:L114	5.245	4	2	5
12	R:R:I118	6.7825	4	2	7
13	R:R:F133	9.285	4	6	6
14	R:R:Y138	6.492	5	0	8
15	R:R:W155	5.41	4	0	9
16	R:R:F168	7.2825	4	0	4
17	R:R:F182	6.26667	6	0	6
18	R:R:M185	5.62	4	2	6
19	R:R:F188	5.7475	4	2	5
20	R:R:Y193	5.72286	7	5	9
21	R:R:N214	5	4	0	6
22	R:R:F228	5.81	4	2	9
23	R:R:W232	8.335	6	2	8
24	R:R:I265	4.6575	4	2	7
25	R:R:P273	6.08	4	4	9
26	R:R:I275	4.625	4	0	8
27	R:R:Y276	9.0575	4	5	9
28	R:R:E282	7.1275	4	1	6
29	R:R:L283	3.18	4	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F31	R:R:K77	16.0341	13.65	Yes	Yes	0	5	6
2	R:R:K77	R:R:S35	13.4278	6.12	Yes	No	0	6	6
3	R:R:S35	R:R:S74	11.797	3.26	No	No	0	6	8
4	R:R:S74	R:R:V39	11.3093	3.23	No	No	0	8	6
5	R:R:M71	R:R:V39	11.9951	6.09	No	No	0	7	6
6	R:R:M71	R:R:N42	14.1442	4.21	No	Yes	0	7	9
7	R:R:N42	R:R:P273	11.5379	8.15	Yes	Yes	4	9	9
8	R:R:E41	R:R:P273	18.5947	7.86	No	Yes	0	7	9
9	R:R:E41	R:R:V270	11.9646	4.28	No	No	0	7	6
10	R:R:E41	R:R:F274	10.2423	3.5	No	No	0	7	6
11	R:R:A67	R:R:N42	10.913	4.69	No	Yes	0	9	9
12	R:R:D70	R:R:N42	13.8089	12.12	Yes	Yes	4	9	9
13	R:R:D272	R:R:D70	62.3685	5.32	No	Yes	0	9	9
14	R:R:D272	R:R:N268	63.4202	10.77	No	No	0	9	9
15	R:R:N268	R:R:W232	71.5287	7.91	No	Yes	0	9	8
16	R:R:I265	R:R:W232	56.6682	8.22	Yes	Yes	2	7	8
17	R:R:I265	R:R:M266	53.6808	4.37	Yes	No	0	7	6
18	R:R:K77	R:R:M266	34.7508	8.64	Yes	No	0	6	6
19	R:R:A277	R:R:P273	65.676	1.87	No	Yes	0	8	9
20	R:R:A277	R:R:I63	63.7708	6.5	No	No	0	8	8
21	R:R:I63	R:R:Y60	61.9265	2.42	No	Yes	0	8	8
22	R:R:L283	R:R:Y60	26.6575	4.69	Yes	Yes	1	8	8
23	R:R:F278	R:R:L283	10.3643	4.87	No	Yes	0	6	8
24	R:R:S117	R:R:W232	87.1971	6.18	No	Yes	0	9	8
25	R:R:S117	R:R:S69	84.8651	4.89	No	No	0	9	8
26	R:R:S69	R:R:W155	82.9904	3.71	No	Yes	0	8	9
27	R:R:S65	R:R:W155	77.2596	6.18	No	Yes	0	9	9
28	R:R:L151	R:R:S65	75.3391	6.01	No	No	0	6	9
29	R:R:F62	R:R:L151	73.6626	3.65	Yes	No	0	8	6
30	R:R:F62	R:R:T147	41.3809	2.59	Yes	No	0	8	7
31	R:R:M144	R:R:T147	37.3876	6.02	No	No	0	2	7
32	R:R:F61	R:R:M144	17.9089	9.95	No	No	0	4	2
33	R:R:A286	R:R:L283	10.3185	1.58	No	Yes	1	8	8
34	R:R:A57	R:R:Y60	29.2638	2.67	No	Yes	0	7	8
35	R:R:A57	R:R:P58	26.9624	1.87	No	No	0	7	6
36	R:R:P58	R:R:T147	28.136	10.49	No	No	0	6	7
37	R:R:F62	R:R:V123	26.9014	7.87	Yes	No	0	8	6
38	R:R:D127	R:R:F62	29.8125	7.17	No	Yes	0	9	8
39	R:R:D70	R:R:L66	23.2129	5.43	Yes	Yes	0	9	9
40	R:R:F228	R:R:W232	100	8.02	Yes	Yes	2	9	8
41	R:R:F228	R:R:I189	66.2399	3.77	Yes	No	0	9	8
42	R:R:I189	R:R:Y193	64.7767	4.84	No	Yes	0	8	9
43	R:R:Y193	R:R:Y276	19.3111	8.94	Yes	Yes	5	9	9
44	R:R:D107	R:R:Y76	23.3196	4.6	No	Yes	0	4	5
45	R:R:M266	R:R:Y76	34.5374	4.79	No	Yes	0	6	5
46	R:R:L109	R:R:Y76	35.2843	3.52	No	Yes	0	5	5
47	R:R:F110	R:R:Y76	40.2987	23.73	Yes	Yes	0	5	5
48	R:R:I105	R:R:S108	11.8732	6.19	No	No	0	4	5
49	R:R:L109	R:R:S108	17.7717	1.5	No	No	0	5	5
50	R:R:L109	R:R:L112	11.8732	4.15	No	No	0	5	5
51	R:R:F110	R:R:V111	40.6341	5.24	Yes	No	0	5	4
52	R:R:F110	R:R:F235	29.4162	16.08	Yes	No	0	5	6
53	R:R:M165	R:R:V111	37.3876	6.09	No	No	0	4	4
54	R:R:C158	R:R:L115	10.0899	3.17	No	No	0	7	5
55	R:R:L115	R:R:L181	16.659	4.15	No	No	0	5	4
56	R:R:I118	R:R:L181	19.9055	5.71	Yes	No	0	7	4
57	R:R:I118	R:R:W232	43.4842	10.57	Yes	Yes	2	7	8
58	R:R:I118	R:R:M185	44.0939	5.83	Yes	Yes	2	7	6
59	R:R:F188	R:R:M185	31.7482	4.98	Yes	Yes	2	5	6
60	R:R:V123	R:R:V150	23.7007	3.21	No	No	0	6	5
61	R:R:D127	R:R:Y138	26.8709	5.75	No	Yes	0	9	8
62	R:R:F188	R:R:L192	25.865	7.31	Yes	No	0	5	7
63	R:R:L192	R:R:Y129	22.6337	11.72	No	No	0	7	8
64	R:R:F133	R:R:Y129	16.3847	11.35	Yes	No	6	6	8
65	R:R:V142	R:R:Y138	10.41	7.57	No	Yes	0	7	8
66	R:R:M144	R:R:V148	17.5278	4.56	No	No	0	2	1
67	R:R:V149	R:R:V150	20.6066	1.6	No	No	0	3	5
68	R:R:R146	R:R:V149	12.3304	1.31	No	No	0	7	3
69	R:R:T152	R:R:V149	10.913	1.59	No	No	0	3	3
70	R:R:T152	R:R:V153	12.3	1.59	No	No	0	3	3
71	R:R:T152	R:R:V148	14.068	1.59	No	No	0	3	1
72	R:R:M165	R:R:T174	27.4653	1.51	No	No	0	4	5
73	R:R:F168	R:R:T174	24.417	1.3	Yes	No	0	4	5
74	R:R:F168	R:R:P173	10.6386	4.33	Yes	No	0	4	3
75	R:R:F178	R:R:F235	26.185	5.36	No	No	0	4	6
76	R:R:F178	R:R:V239	29.9497	5.24	No	No	0	4	5
77	R:R:V175	R:R:V239	13.062	4.81	No	No	0	4	5
78	R:R:F178	R:R:V236	30.5746	3.93	No	No	0	4	5
79	R:R:F182	R:R:F228	90.3673	6.43	Yes	Yes	0	6	9
80	R:R:F182	R:R:V236	32.495	9.18	Yes	No	0	6	5
81	R:R:T179	R:R:V239	13.062	1.59	No	No	0	4	5
82	R:R:F182	R:R:I229	11.233	5.02	Yes	No	0	6	6
83	R:R:A233	R:R:F182	62.46	5.55	No	Yes	0	5	6
84	R:R:L221	R:R:Y193	42.5697	5.86	No	Yes	0	7	9
85	R:R:L224	R:R:Y193	16.1408	3.52	No	Yes	5	8	9
86	R:R:F197	R:R:L221	23.3653	3.65	No	No	0	6	7
87	R:R:F197	R:R:N214	16.6133	6.04	No	Yes	0	6	6
88	R:R:L221	R:R:V194	16.9639	2.98	No	No	0	7	3
89	R:R:L198	R:R:V194	13.565	1.49	No	No	0	3	3
90	R:R:L198	R:R:R201	10.1204	2.43	No	No	0	3	6
91	R:R:I275	R:R:L224	15.2111	4.28	Yes	No	0	8	8
92	R:R:C231	R:R:N268	10.6843	11.02	No	No	0	8	9
93	R:R:A233	R:R:P234	59.1983	1.87	No	No	0	5	9
94	R:R:N261	R:R:P234	55.8756	4.89	No	No	0	5	9
95	R:R:H238	R:R:N261	42.7069	14.03	No	No	0	5	5
96	R:R:H238	R:R:M255	39.5367	10.51	No	No	0	5	1
97	R:R:C245	R:R:L241	29.3705	6.35	No	No	0	4	4
98	R:R:L241	R:R:M255	32.8761	4.24	No	No	0	4	1
99	R:R:C245	R:R:C251	22.207	7.28	No	No	0	4	4
100	R:R:C251	R:R:N248	18.5795	6.3	No	No	0	4	4
101	R:R:N248	R:R:Y250	11.233	3.49	No	No	0	4	4
102	R:R:N261	R:R:V260	11.233	2.96	No	No	0	5	3
103	R:R:D107	R:R:I106	17.7412	2.8	No	No	0	4	5
104	R:R:F32	R:R:K77	12.8487	9.93	Yes	Yes	3	4	6
105	R:R:L66	R:R:Y276	19.4178	3.52	Yes	Yes	0	9	9
106	R:R:F274	R:R:I275	10.2576	5.02	No	Yes	0	6	8
107	R:R:D70	R:R:P273	59.4879	6.44	Yes	Yes	4	9	9
108	R:R:L114	R:R:W232	77.9302	9.11	Yes	Yes	2	5	8
109	R:R:F110	R:R:L114	71.4678	6.09	Yes	Yes	0	5	5
110	R:R:F228	R:R:I118	20.759	5.02	Yes	Yes	2	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9K3L_nogp

PDB Summary
PDB	9K3L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	218
Number of Links	232
Number of Hubs	29
Number of Links mediated by Hubs	108
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	36

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	24946
Length Of Smallest Path	3
Average Path Length	11.5865
Length of Longest Path	26
Minimum Path Strength	1.3
Average Path Strength	5.93537
Maximum Path Strength	19.905
Minimum Path Correlation	0.7
Average Path Correlation	0.911207
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	45.3949
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.5758
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • corticotropin receptor activity • neuropeptide receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • intracellular anatomical structure • cytoplasm • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01718
Sequence	>9K3L_nogp_Chain_R P E E I F F T I S I V G V L E N L I V L L A V F K N K N L Q A P M Y F F I C S L A I S D M L G S L Y K I L E N A D D I I D S L F V L S L L G S I F S L S V I A A D R Y I T I F H A L R Y H S I V T M R R T V V V L T V I W T F C T G T G I T M V I F S H H V P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H T R K I A N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C P S N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E L R D A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GY7	A	Peptide	Melanocortin	MC₂	Homo sapiens	Corticotropin	Ca	chim(NtGi1-Gs)/β1/γ2; MRAP1	3.3	2023-01-11	doi.org/10.1038/s41422-022-00751-6
	8GY7 (No Gprot)	A	Peptide	Melanocortin	MC₂	Homo sapiens	Corticotropin	Ca		3.3	2023-01-11	doi.org/10.1038/s41422-022-00751-6
	9K3L	A	Peptide	Melanocortin	MC₂	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.01	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3L (No Gprot)	A	Peptide	Melanocortin	MC₂	Homo sapiens	-	-		3.01	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K3L_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.