Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F52 5.53833639
2R:R:H55 3.942538
3R:R:L67 4.472533
4R:R:I73 3.228537
5R:R:H74 4.628537
6R:R:R75 5.965634
7R:R:L76 5.12434
8R:R:E77 4.654538
9R:R:M79 4.046508
10R:R:Y81 7.6225407
11R:R:L92 5.022566
12R:R:L98 3.8925409
13R:R:G99 2.225289
14R:R:V100 4.2875407
15R:R:R101 4.294175
16R:R:I102 6.072538
17R:R:L103 5.85175
18R:R:D104 6.475439
19R:R:F119 5.625175
20R:R:I147 2.55754175
21R:R:G149 2.18408
22R:R:I151 2.8775407
23R:R:V158 3.17503
24R:R:S159 4.9775498
25R:R:V162 3.378595
26R:R:L166 4.645496
27R:R:F169 5.206506
28R:R:P172 4.01469
29R:R:Q173 4.23498
30R:R:Y176 5.73333637
31R:R:S178 4.01498
32R:R:P181 3.0525405
33R:R:E182 7.81494
34R:R:L183 6.48698
35R:R:Y189 6.41286796
36R:R:F191 4.51167667
37R:R:F192 6.182598
38R:R:R194 6.388599
39R:R:P198 5.554597
40R:R:Q202 6.5325109
41R:R:M206 3.5085107
42R:R:V207 2.875306
43R:R:I209 4.3854108
44R:R:W215 5.154297139
45R:R:Y217 4.518519
46R:R:L221 3.86415
47R:R:S223 2.84406
48R:R:Y227 6.2256107
49R:R:V232 2.625405
50R:R:F235 3.895405
51R:R:V245 2.414307
52R:R:Q249 6.21416
53R:R:Q251 5.694515
54R:R:P257 5.0454223
55R:R:E261 6.365224
56R:R:F262 8.96254223
57R:R:I266 1.9025404
58R:R:L269 4.046516
59R:R:V278 4.7525416
60R:R:M280 3.226515
61R:R:F281 7.186107
62R:R:D286 6.5675404
63R:R:I287 4.445414
64R:R:K295 6.5925412
65R:R:F303 6.7525417
66R:R:W305 7.048517
67R:R:S308 7.04254108
68R:R:W311 4.48625816
69R:R:P317 5.716513
70R:R:Q321 6.09613
71R:R:I324 3.2325414
72R:R:T330 4.026516
73R:R:L332 5.188515
74R:R:I338 3.082536
75R:R:F341 3.93111938
76R:R:Y344 6.635637
77R:R:F345 6.70714736
78R:R:R348 8.9125435
79R:R:R355 5.938504
80R:R:N356 5.2725438
81R:R:W358 6.3575434
82R:R:F359 5.238535
83R:R:F362 5.75857736
84R:R:N366 7.3875433
85R:R:F367 7.11637
86R:R:K383 1.90754311
87R:R:T385 4.82535
88R:R:R389 7.832534
89R:R:Y396 5.70143735
90R:R:Q398 7.94167636
91R:R:E399 5.5175435
92R:R:K401 4.0125434
93R:R:Q403 6.476537
94R:R:I406 3.1625408
95R:R:Y410 4.18567
96R:R:M419 4.266565
97R:R:L423 2.9875464
98R:R:M434 3.9475464
99R:R:L442 3.22833666
100R:R:I446 3.1075466
101R:R:F451 7.08669
102R:R:T457 3.6405
103R:R:F461 3.095408
104R:R:D466 6.3125498
105R:R:Y471 4.7145108
106R:R:F474 7.02833615
107R:R:Q475 8.734138
108R:R:Y476 8.082515
109R:R:Q477 6.1785136
110R:R:Y485 7.85414
111R:R:W491 6.1065106
112R:R:L495 3.7685107
113R:R:L497 5.02754106
114R:R:K498 3.244325
115R:R:M502 5.815137
116R:R:W504 5.282867137
117R:R:P512 4.6165138
118R:R:K526 4.25418
119R:R:C535 3.1325419
120R:R:C556 5.4145159
121R:R:R561 5.203336156
122R:R:C569 6.54159
123R:R:I595 4.1406
124R:R:T604 3.92754186
125R:R:F605 4.234189
126R:R:T611 5.224239
127R:R:I613 4.14237
128R:R:E620 5.625346
129R:R:Y633 3.97508
130R:R:P643 4.37254249
131R:R:R651 4.9054248
132R:R:R652 10.275459
133R:R:V653 4.1325405
134R:R:M659 4.6075458
135R:R:Y663 6.3925457
136R:R:I698 4.7785357
137R:R:L702 7.0554375
138R:R:V715 8.116552
139R:R:Q728 8.2175405
140R:R:R737 9.43754334
141R:R:L753 4.374558
142R:R:Y755 9.69254379
143R:R:M760 4.952558
144R:R:C763 4.4825458
145R:R:Y766 8.17667657
146R:R:V773 6.0225458
147R:R:E779 2.4125409
148R:R:I783 3.62409
149R:R:G784 2.8125409
150R:R:M787 3.56167659
151R:R:T790 3.905459
152R:R:W794 4.97659
153R:R:F797 4.86659
154R:R:F801 5.21714758
155R:R:L833 4.7875408
156R:R:Y834 4.967189
157R:R:I841 6.22754239
158S:S:F52 5.53833649
159S:S:H55 3.942548
160S:S:L67 4.472543
161S:S:I73 3.228547
162S:S:H74 4.628547
163S:S:R75 5.965644
164S:S:L76 5.12444
165S:S:E77 4.654548
166S:S:M79 4.046508
167S:S:Y81 7.6225407
168S:S:L92 5.022576
169S:S:L98 3.8925409
170S:S:G99 2.225399
171S:S:V100 4.2875407
172S:S:R101 4.294195
173S:S:I102 6.072548
174S:S:L103 5.85195
175S:S:D104 6.475449
176S:S:F119 5.625195
177S:S:I147 2.55754195
178S:S:G149 2.18408
179S:S:I151 2.8775407
180S:S:V158 3.17503
181S:S:S159 4.97754118
182S:S:V162 3.3785115
183S:S:L166 4.6454116
184S:S:F169 5.206506
185S:S:P172 4.01479
186S:S:Q173 4.234118
187S:S:Y176 5.73333647
188S:S:S178 4.014118
189S:S:P181 3.0525405
190S:S:E182 7.814114
191S:S:L183 6.486118
192S:S:Y189 6.412867116
193S:S:F191 4.51167677
194S:S:F192 6.1825118
195S:S:R194 6.3885119
196S:S:P198 5.5545117
197S:S:Q202 6.5325129
198S:S:M206 3.5085127
199S:S:V207 2.875416
200S:S:I209 4.3854128
201S:S:W215 5.154297149
202S:S:Y217 4.518529
203S:S:L221 3.86425
204S:S:S223 2.84406
205S:S:Y227 6.2256127
206S:S:V232 2.625405
207S:S:F235 3.895405
208S:S:V245 2.414417
209S:S:Q249 6.21426
210S:S:Q251 5.694525
211S:S:P257 5.0454253
212S:S:E261 6.365254
213S:S:F262 8.96254253
214S:S:I266 1.9025404
215S:S:L269 4.046526
216S:S:V278 4.7525426
217S:S:M280 3.226525
218S:S:F281 7.186127
219S:S:D286 6.5675404
220S:S:I287 4.445424
221S:S:F303 6.7525427
222S:S:W305 7.048527
223S:S:S308 7.04254128
224S:S:W311 4.48625826
225S:S:P317 5.716523
226S:S:Q321 5.41167623
227S:S:I324 3.96424
228S:S:T330 4.026526
229S:S:L332 5.188525
230S:S:I338 3.082546
231S:S:F341 3.93111948
232S:S:Y344 6.635647
233S:S:F345 6.70714746
234S:S:R348 8.9125445
235S:S:R355 5.938504
236S:S:N356 5.2725448
237S:S:W358 6.3575444
238S:S:F359 5.238545
239S:S:F362 5.75857746
240S:S:N366 7.3875443
241S:S:F367 7.11647
242S:S:K383 1.90754421
243S:S:T385 4.82545
244S:S:R389 7.832544
245S:S:Y396 5.70143745
246S:S:Q398 7.94167646
247S:S:E399 5.5175445
248S:S:K401 4.0125444
249S:S:Q403 6.476547
250S:S:I406 3.1625408
251S:S:Y410 4.18577
252S:S:M419 4.266575
253S:S:L423 2.9875474
254S:S:M434 3.9475474
255S:S:L442 3.22833676
256S:S:I446 3.1075476
257S:S:F451 7.08679
258S:S:T457 3.6405
259S:S:F461 3.095408
260S:S:D466 6.31254118
261S:S:Y471 4.7145128
262S:S:F474 7.02833625
263S:S:Q475 8.734148
264S:S:Y476 8.082525
265S:S:Q477 6.1785146
266S:S:Y485 7.85424
267S:S:W491 6.1065126
268S:S:L495 3.7685127
269S:S:L497 5.02754126
270S:S:K498 3.244435
271S:S:M502 5.815147
272S:S:W504 5.282867147
273S:S:P512 4.6165148
274S:S:K526 4.25428
275S:S:C535 3.1325429
276S:S:C556 5.4145169
277S:S:R561 5.203336166
278S:S:C569 6.54169
279S:S:I595 4.1406
280S:S:T604 3.92754206
281S:S:F605 4.234209
282S:S:T611 5.224269
283S:S:I613 4.14267
284S:S:E620 5.625446
285S:S:Y633 3.97508
286S:S:P643 4.37254279
287S:S:R651 4.9054278
288S:S:R652 10.2154479
289S:S:M659 4.6075488
290S:S:Y663 6.705487
291S:S:I698 4.7785457
292S:S:L702 7.0554485
293S:S:Q728 7.05405
294S:S:R737 9.84754214
295S:S:V739 4.76754216
296S:S:K741 4.96754216
297S:S:L753 4.374588
298S:S:Y755 9.69254489
299S:S:M760 4.952588
300S:S:C763 4.4825488
301S:S:V773 6.02254508
302S:S:E779 2.4125409
303S:S:I783 3.62409
304S:S:G784 2.8125409
305S:S:M787 3.56167689
306S:S:T790 4.2175489
307S:S:W794 4.97689
308S:S:F797 4.86689
309S:S:I798 4.93487
310S:S:F801 5.83788
311S:S:L833 4.7875408
312S:S:Y834 4.967209
313S:S:I841 6.22754269
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:A180 R:R:E182 86.67523.02NoYes074
2R:R:E182 R:R:Y189 84.50056.73YesYes946
3R:R:A163 R:R:Y189 14.73734NoYes076
4R:R:A163 R:R:Q173 14.693.03NoYes078
5R:R:L166 R:R:Q173 14.15263.99YesYes968
6R:R:R188 R:R:Y189 98.87257.2NoYes066
7R:R:R188 S:S:R188 98.94717.46NoNo066
8S:S:R188 S:S:Y189 98.96957.2NoYes066
9R:R:D199 R:R:P181 85.46753.22NoYes085
10R:R:A180 R:R:P181 87.13441.87NoYes075
11R:R:D199 R:R:Y227 85.64012.3NoYes087
12R:R:A275 R:R:Y217 90.03682.67NoYes179
13R:R:A275 R:R:S219 90.20171.71NoNo178
14R:R:Q249 R:R:S219 41.64732.89YesNo168
15R:R:Q249 R:R:Q251 41.720214.08YesYes165
16R:R:I265 R:R:Q251 83.66392.74NoYes055
17R:R:I253 R:R:I265 84.09532.94NoNo065
18R:R:I253 R:R:S223 84.20783.1NoYes066
19R:R:G228 R:R:S223 85.93981.86NoYes086
20R:R:G228 R:R:Y227 84.25725.79NoYes1087
21R:R:L269 R:R:S219 48.63363YesNo168
22R:R:L269 R:R:Q251 41.82655.32YesYes165
23R:R:C516 R:R:Y217 89.03478.06NoYes199
24R:R:C516 R:R:C535 87.75657.28NoYes199
25R:R:P562 R:R:R561 86.1742.88NoYes1586
26R:R:C556 R:R:P562 43.17287.53YesNo1598
27R:R:C556 R:R:Y546 43.42135.38YesNo1598
28R:R:Q547 R:R:Y546 86.83654.51NoNo038
29R:R:C553 R:R:Q547 87.07581.53NoNo093
30R:R:C553 R:R:R525 87.39472.79NoNo096
31R:R:E539 R:R:R525 87.474311.63NoNo046
32R:R:E539 R:R:H537 87.5543.69NoNo046
33R:R:H537 R:R:V529 87.6955.54NoNo065
34R:R:C535 R:R:V529 87.77471.71YesNo095
35R:R:C569 R:R:P562 43.16987.53YesNo1598
36R:R:C569 R:R:Y546 43.33555.38YesNo1598
37R:R:Q728 R:R:T730 83.1364.25YesNo055
38R:R:A736 R:R:T730 83.30493.36NoNo045
39R:R:A736 R:R:I572 83.47381.62NoNo048
40R:R:I572 R:R:R561 83.63397.52NoYes1586
41R:R:E809 R:R:Y812 72.34616.73NoNo087
42R:R:A808 R:R:E809 72.51514.53NoNo048
43R:R:A808 R:R:Q806 72.68411.52NoNo047
44R:R:Q806 R:R:S807 72.85321.44NoNo075
45R:R:Q728 R:R:S807 73.02241.44YesNo055
46R:R:T598 R:R:Y633 10.36182.5NoYes078
47R:R:I629 R:R:T598 10.70731.52NoNo087
48R:R:I629 R:R:Y834 11.39822.42NoYes089
49R:R:L833 R:R:Y834 44.86215.86YesYes089
50R:R:L833 R:R:T786 45.86977.37YesNo089
51R:R:M787 R:R:T786 46.21384.52YesNo099
52R:R:M787 R:R:T764 30.85123.01YesNo598
53R:R:M760 R:R:T764 31.02153.01YesNo588
54R:R:M760 R:R:W794 63.42032.33YesYes589
55R:R:F797 R:R:W794 65.36089.02YesYes599
56R:R:F797 R:R:T817 69.80392.59YesNo098
57R:R:T816 R:R:T817 70.3151.57NoNo088
58R:R:T816 R:R:W583 70.48464.85NoNo086
59R:R:W583 R:R:Y812 70.82378.68NoNo067
60R:R:M787 R:R:T790 30.87466.02YesYes599
61R:R:M760 R:R:T790 31.19373.01YesYes589
62R:R:F605 R:R:Y834 14.15575.16YesYes1899
63R:R:L626 R:R:Y834 11.04724.69NoYes099
64R:R:G618 R:R:S622 17.95611.86NoNo098
65R:R:G618 R:R:S617 17.26563.71NoNo099
66R:R:K669 R:R:S617 16.57514.59NoNo099
67R:R:K669 R:R:L621 15.88479.87NoNo098
68S:S:A163 S:S:Y189 10.02614NoYes076
69S:S:L166 S:S:Q173 11.59063.99YesYes1168
70S:S:E182 S:S:Y189 96.69396.73YesYes1146
71S:S:A180 S:S:E182 1003.02NoYes074
72S:S:A180 S:S:P181 1001.87NoYes075
73S:S:D199 S:S:P181 1003.22NoYes085
74S:S:D199 S:S:Y227 1002.3NoYes087
75S:S:G228 S:S:Y227 1005.79NoYes1287
76S:S:G228 S:S:S223 1001.86NoYes086
77S:S:I253 S:S:S223 1003.1NoYes066
78S:S:I253 S:S:I265 1002.94NoNo065
79S:S:I265 S:S:Q251 1002.74NoYes055
80S:S:Q249 S:S:Q251 53.899614.08YesYes265
81S:S:Q249 S:S:S219 53.88492.89YesNo268
82S:S:A275 S:S:S219 1001.71NoNo278
83S:S:A275 S:S:Y217 1002.67NoYes279
84S:S:L269 S:S:Q251 53.94745.32YesYes265
85S:S:L269 S:S:S219 71.61723YesNo268
86S:S:C516 S:S:Y217 1008.06NoYes299
87S:S:Q403 S:S:T457 15.18267.09YesYes075
88S:S:R470 S:S:T457 15.32793.88NoYes045
89S:S:I338 S:S:Q403 13.08194.12YesYes467
90S:S:R470 S:S:T492 15.38629.06NoNo045
91S:S:F474 S:S:V487 16.1326.55YesNo055
92S:S:G489 S:S:V487 16.05071.84NoNo095
93S:S:G489 S:S:K498 15.973.49NoYes095
94S:S:H490 S:S:K498 15.72852.62NoYes025
95S:S:H490 S:S:T492 15.56892.74NoNo025
96S:S:C516 S:S:C535 1007.28NoYes299
97S:S:C535 S:S:V529 1001.71YesNo095
98S:S:H537 S:S:V529 1005.54NoNo065
99S:S:H537 S:S:K527 62.26393.93NoNo065
100S:S:K527 S:S:R525 62.224917.33NoNo056
101S:S:C553 S:S:R525 1002.79NoNo096
102S:S:C553 S:S:Q547 1001.53NoNo093
103S:S:Q547 S:S:Y546 1004.51NoNo038
104S:S:C556 S:S:Y546 61.88485.38YesNo1698
105S:S:C556 S:S:P562 61.61487.53YesNo1698
106S:S:P562 S:S:R561 1002.88NoYes1686
107S:S:E539 S:S:H537 62.26393.69NoNo046
108S:S:E539 S:S:R525 62.224911.63NoNo046
109S:S:C569 S:S:Y546 61.79095.38YesNo1698
110S:S:C569 S:S:P562 61.61097.53YesNo1698
111S:S:I572 S:S:R561 1007.52NoYes1686
112S:S:A736 S:S:I572 1001.62NoNo048
113S:S:A736 S:S:T730 1003.36NoNo045
114S:S:Q728 S:S:T730 1004.25YesNo055
115S:S:Q728 S:S:R737 60.714418.69YesYes054
116S:S:E727 S:S:Q728 57.33073.82NoYes055
117S:S:D724 S:S:E727 57.144620.79NoNo075
118S:S:D724 S:S:K741 56.95856.91NoYes2176
119S:S:K741 S:S:M811 1002.88YesNo065
120S:S:R737 S:S:V739 57.14643.92YesYes2146
121S:S:K741 S:S:V739 56.96284.55YesYes2166
122S:S:M811 S:S:T815 1001.51NoNo058
123S:S:M639 S:S:T815 1001.51NoNo088
124S:S:M639 S:S:R651 1008.69NoYes088
125S:S:L638 S:S:R651 1002.43NoYes058
126S:S:F654 S:S:L638 1002.44NoNo045
127S:S:F654 S:S:V653 1003.93NoNo045
128S:S:L657 S:S:V653 1002.98NoNo075
129S:S:G658 S:S:L657 1001.71NoNo077
130S:S:G658 S:S:L631 1005.13NoNo075
131S:S:F661 S:S:L631 1002.44NoNo075
132S:S:F661 S:S:T627 1003.89NoNo075
133S:S:G628 S:S:T627 99.73581.82NoNo085
134S:S:G628 S:S:S662 99.3611.86NoNo087
135S:S:S662 S:S:Y663 98.98623.82NoYes077
136S:S:T790 S:S:Y663 73.02116.24YesYes897
137S:S:M787 S:S:T790 72.30846.02YesYes899
138S:S:M787 S:S:T786 52.02434.52YesNo099
139S:S:L833 S:S:T786 51.64817.37YesNo089
140S:S:L833 S:S:Y834 50.55465.86YesYes089
141S:S:I629 S:S:Y834 12.46042.42NoYes089
142S:S:I629 S:S:T598 11.70511.52NoNo087
143S:S:T598 S:S:Y633 11.32742.5NoYes078
144S:S:F605 S:S:Y834 16.22995.16YesYes2099
145S:S:L626 S:S:Y834 12.83184.69NoYes099
146S:S:F605 S:S:S622 10.94542.64YesNo098
147S:S:L626 S:S:S622 10.94963NoNo098
148S:S:G618 S:S:S622 21.13951.86NoNo098
149S:S:G618 S:S:S617 20.38463.71NoNo099
150S:S:K669 S:S:S617 19.62974.59NoNo099
151S:S:K669 S:S:L621 18.87499.87NoNo098
152S:S:E620 S:S:L621 10.57063.98YesNo068
153S:S:M659 S:S:Y663 12.80043.59YesYes887
154S:S:M659 S:S:W794 11.66825.82YesYes889
155S:S:M760 S:S:Y663 12.796913.17YesYes887
156S:S:M760 S:S:W794 11.7422.33YesYes889
157S:S:C763 S:S:M787 10.5753.24YesYes889
158S:S:F797 S:S:W794 12.83689.02YesYes899
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9MBD
Class C
SubFamily Aminoacid
Type Metabotropic glutamate
SubType mGlu8; mGlu8
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.32
Date 2025-10-01
D.O.I. doi.org/10.1016/j.molcel.2025.08.019
Net Summary
Imin 1.71
Number of Linked Nodes 1454
Number of Links 1865
Number of Hubs 313
Number of Links mediated by Hubs 1138
Number of Communities 50
Number of Nodes involved in Communities 487
Number of Links involved in Communities 715
Path Summary
Number Of Nodes in MetaPath 159
Number Of Links MetaPath 158
Number of Shortest Paths 26140076
Length Of Smallest Path 3
Average Path Length 122.786
Length of Longest Path 133
Minimum Path Strength 1.3
Average Path Strength 8.00034
Maximum Path Strength 18.6
Minimum Path Correlation 0.81
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 7.5
Average % Of Corr. Nodes 64.5538
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.0421
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • cell surface receptor signaling pathway   • signaling   • biological regulation   • glutamate receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • multicellular organismal process   • sensory perception of light stimulus   • system process   • sensory perception   • nervous system process   • visual perception   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • synaptic transmission, glutamatergic   • cell-cell signaling   • regulation of synaptic transmission, glutamatergic   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane
Gene OntologyCellular Component
SCOP2Domain Identifier• Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO00222
Sequence
>9MBD_Chain_R
SIRVDGDII LGGLFPVHA KGERGVPCG ELKKEKGIH RLEAMLYAI 
DQINKDPDL LSNITLGVR ILDTCSRDT YALEQSLTF VQALIPIFT 
KPDKISGVI GAAASSVSI MVANILRLF KIPQISYAS TAPELSDNT 
RYDFFSRVV PPDSYQAQA MVDIVTALG WNYVSTLAS EGNYGESGV 
EAFTQISRE IGGVCIAQS QKIPREPRP GEFEKIIKR LLETPNARA 
VIMFANEDD IRRILEAAK KLNQSGHFL WIGSDSWGS KIAPVYQQE 
EIAEGAVTI LPKRASIDG FDRYFRSRT LANNRRNVW FAEFWEENF 
GCKLGSHIK KCTGLERIA RDSSYEQEG KVQFVIDAV YSMAYALHN 
MHKDLCPGY IGLCPRMST IDGKELLGY IRAVNFNGS AGTPVTFNE 
NGDAPGRYD IFQYQITNK STEYKVIGH WTNQLHLKV EDMQWAHTH 
PASVCSLPC KPGERKKTV KGVPCCWHC ERCEGYNYQ VDELSCELC 
PLDQRPNMN RTGCQLIPI IKLEWHSPW AVVPVFVAI LGIIATTFV 
IVTFVRYND TPIVRASGR ELSYVLLTG IFLCYSITF LMIAAPDTI 
ICSFRRVFL GLGMCFSYA ALLTKTNRI HRIFEKFIS PASQLVITF 
SLISVQLLG VFVWFVVDP PHIIIDYGE QRTLDPEKA RGVLKCDIS 
DLSLICSLG YSILLMVTC TVYAIKTRG VPETFNEAK PIGFTMYTT 
CIIWLAFIP IFFGTAQSA EKMYIQTTT LTVSMSLSA SVSLGMLYM 
PKVYII


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO00222
Sequence
>9MBD_Chain_S
SIRVDGDII LGGLFPVHA KGERGVPCG ELKKEKGIH RLEAMLYAI 
DQINKDPDL LSNITLGVR ILDTCSRDT YALEQSLTF VQALIPIFT 
KPDKISGVI GAAASSVSI MVANILRLF KIPQISYAS TAPELSDNT 
RYDFFSRVV PPDSYQAQA MVDIVTALG WNYVSTLAS EGNYGESGV 
EAFTQISRE IGGVCIAQS QKIPREPRP GEFEKIIKR LLETPNARA 
VIMFANEDD IRRILEAAK KLNQSGHFL WIGSDSWGS KIAPVYQQE 
EIAEGAVTI LPKRASIDG FDRYFRSRT LANNRRNVW FAEFWEENF 
GCKLGSHIK KCTGLERIA RDSSYEQEG KVQFVIDAV YSMAYALHN 
MHKDLCPGY IGLCPRMST IDGKELLGY IRAVNFNGS AGTPVTFNE 
NGDAPGRYD IFQYQITNK STEYKVIGH WTNQLHLKV EDMQWAHTH 
PASVCSLPC KPGERKKTV KGVPCCWHC ERCEGYNYQ VDELSCELC 
PLDQRPNMN RTGCQLIPI IKLEWHSPW AVVPVFVAI LGIIATTFV 
IVTFVRYND TPIVRASGR ELSYVLLTG IFLCYSITF LMIAAPDTI 
ICSFRRVFL GLGMCFSYA ALLTKTNRI HRIFEKFIS PASQLVITF 
SLISVQLLG VFVWFVVDP PHIIIDYGE QRTLDPEKA RGVLKCDIS 
DLSLICSLG YSILLMVTC TVYAIKTRG VPETFNEAK PIGFTMYTT 
CIIWLAFIP IFFGTAQSA EKMYIQTTT LTVSMSLSA SVSLGMLYM 
PKVYII


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9MBACAminoacidMetabotropic glutamatemGlu8; mGlu8Homo sapiensGlutamate-Arrestin2 ; Arrestin23.142025-10-01doi.org/10.1016/j.molcel.2025.08.019
9MBBCAminoacidMetabotropic glutamatemGlu8; mGlu8Homo sapiensLY341495--3.252025-10-01doi.org/10.1016/j.molcel.2025.08.019
9MBCCAminoacidMetabotropic glutamatemGlu8; mGlu8Homo sapiensDCPGAZ12216052-2.972025-10-01doi.org/10.1016/j.molcel.2025.08.019
9MBDCAminoacidMetabotropic glutamatemGlu8; mGlu8Homo sapiens---3.322025-10-01doi.org/10.1016/j.molcel.2025.08.019




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Download 9MBD.zip



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