psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R27	R:R:Q106	8.18	No	No	0	0	2
2	L:L:T16	R:R:R107	5.17	No	No	0	0	1
3	L:L:E19	R:R:R107	6.98	No	No	0	0	1
4	R:R:D334	R:R:K108	12.44	No	No	0	5	3
5	R:R:H112	R:R:Y109	5.44	No	No	0	4	3
6	R:R:Y109	R:R:Y113	9.93	No	No	0	3	4
7	R:R:Q337	R:R:Y109	6.76	No	No	0	4	3
8	R:R:D110	R:R:L111	6.79	No	No	0	3	1
9	R:R:H112	R:R:I338	10.61	No	No	0	4	3
10	L:L:T16	R:R:Y113	12.48	No	No	0	0	4
11	R:R:I115	R:R:Y342	8.46	No	No	0	4	6
12	R:R:L117	R:R:Y121	9.38	No	No	0	4	5
13	L:L:L17	R:R:L117	4.15	No	No	0	0	4
14	R:R:N120	R:R:S345	8.94	No	No	0	7	6
15	R:R:W166	R:R:Y121	3.86	Yes	No	6	7	5
16	R:R:Q170	R:R:Y121	14.65	No	No	6	6	5
17	R:R:G123	R:R:S349	3.71	No	No	7	8	9
18	R:R:F350	R:R:G123	7.53	Yes	No	7	6	8
19	R:R:H124	R:R:N163	11.48	No	No	0	6	7
20	R:R:H124	R:R:W166	21.16	No	Yes	0	6	7
21	R:R:F353	R:R:V126	5.24	Yes	No	0	5	5
22	R:R:N163	R:R:V128	4.43	No	No	0	7	6
23	R:R:A130	R:R:S356	3.42	No	No	0	6	8
24	R:R:I156	R:R:L131	5.71	No	No	0	7	9
25	R:R:I160	R:R:L131	4.28	No	No	0	7	9
26	R:R:L131	R:R:S356	4.5	No	No	0	9	8
27	R:R:A134	R:R:S356	3.42	No	No	0	8	8
28	R:R:A134	R:R:C360	3.61	No	No	0	8	7
29	R:R:F135	R:R:L139	6.09	No	No	8	5	2
30	R:R:F135	R:R:W153	11.02	No	Yes	8	5	6
31	R:R:F135	R:R:I160	3.77	No	No	0	5	7
32	R:R:C360	R:R:L137	4.76	No	No	0	7	8
33	R:R:F138	R:R:W153	4.01	No	Yes	0	7	6
34	R:R:L139	R:R:W153	6.83	No	Yes	8	2	6
35	R:R:A369	R:R:L141	4.73	No	Yes	0	7	6
36	R:R:R142	R:R:R145	7.46	No	No	0	7	6
37	R:R:I144	R:R:N149	9.91	No	No	0	7	7
38	R:R:E365	R:R:I144	6.83	No	No	0	8	7
39	R:R:C146	R:R:R148	5.57	No	No	0	7	8
40	R:R:I151	R:R:L147	7.14	Yes	Yes	1	8	6
41	R:R:L147	R:R:Y208	8.21	Yes	Yes	1	6	7
42	R:R:F227	R:R:L147	6.09	Yes	Yes	1	7	6
43	R:R:H152	R:R:R148	4.51	Yes	No	0	8	8
44	R:R:E365	R:R:R148	5.82	No	No	0	8	8
45	R:R:I151	R:R:W201	4.7	Yes	Yes	1	8	9
46	R:R:I151	R:R:Y208	4.84	Yes	Yes	1	8	7
47	R:R:F227	R:R:I151	3.77	Yes	Yes	1	7	8
48	R:R:E205	R:R:H152	6.15	Yes	Yes	4	9	8
49	R:R:H152	R:R:L318	3.86	Yes	Yes	4	8	8
50	R:R:H152	R:R:Y359	13.07	Yes	No	4	8	8
51	R:R:N154	R:R:W153	3.39	Yes	Yes	0	8	6
52	R:R:T157	R:R:W153	7.28	No	Yes	0	3	6
53	R:R:N154	R:R:W201	15.82	Yes	Yes	0	8	9
54	R:R:L228	R:R:N154	4.12	No	Yes	0	5	8
55	R:R:L155	R:R:T158	4.42	No	Yes	0	8	8
56	R:R:F159	R:R:L155	7.31	Yes	No	0	9	8
57	R:R:E205	R:R:L155	14.58	Yes	No	0	9	8
58	R:R:N198	R:R:T158	8.77	Yes	Yes	0	8	8
59	R:R:T158	R:R:W201	3.64	Yes	Yes	1	8	9
60	R:R:T158	R:R:W232	3.64	Yes	No	1	8	9
61	R:R:F159	R:R:N198	20.54	Yes	Yes	0	9	8
62	R:R:F159	R:R:Q351	5.86	Yes	Yes	0	9	9
63	R:R:F159	R:R:G352	6.02	Yes	No	0	9	9
64	R:R:F194	R:R:L161	17.05	Yes	No	0	6	5
65	R:R:R162	R:R:V195	9.15	No	No	0	8	6
66	R:R:N198	R:R:R162	7.23	Yes	No	0	8	8
67	R:R:Q348	R:R:R162	4.67	No	No	0	8	8
68	R:R:I187	R:R:M165	4.37	No	Yes	0	6	5
69	R:R:I190	R:R:M165	5.83	No	Yes	9	4	5
70	R:R:F191	R:R:M165	3.73	Yes	Yes	0	6	5
71	R:R:F194	R:R:M165	3.73	Yes	Yes	9	6	5
72	R:R:F167	R:R:W166	4.01	No	Yes	0	6	7
73	R:R:Q170	R:R:W166	21.9	No	Yes	6	6	7
74	R:R:F191	R:R:W166	7.02	Yes	Yes	0	6	7
75	L:L:T10	R:R:W166	4.85	No	Yes	0	0	7
76	R:R:I187	R:R:L169	4.28	No	No	0	6	6
77	R:R:F191	R:R:L169	3.65	Yes	No	0	6	6
78	R:R:D173	R:R:E175	5.2	No	No	0	3	1
79	R:R:D173	R:R:V176	4.38	No	Yes	0	3	2
80	R:R:E175	R:R:H174	9.85	No	No	0	1	2
81	L:L:S25	R:R:H174	5.58	No	No	0	0	2
82	R:R:E181	R:R:V176	8.56	No	Yes	10	3	2
83	R:R:V176	R:R:W183	6.13	Yes	No	10	2	1
84	R:R:C184	R:R:V176	3.42	No	Yes	0	9	2
85	R:R:H177	R:R:Q253	16.07	No	Yes	0	2	4
86	R:R:F256	R:R:H177	3.39	Yes	No	0	7	2
87	L:L:L18	R:R:H177	3.86	No	No	0	0	2
88	L:L:R22	R:R:E178	10.47	No	No	0	0	3
89	R:R:E181	R:R:S179	4.31	No	No	0	3	1
90	R:R:E181	R:R:W183	14.17	No	No	10	3	1
91	R:R:C184	R:R:C254	7.28	No	No	0	9	9
92	R:R:N251	R:R:R185	9.64	No	No	5	5	6
93	R:R:R185	R:R:W255	24.99	No	Yes	5	6	9
94	R:R:F256	R:R:T188	3.89	Yes	No	0	7	7
95	R:R:T189	R:R:W242	3.64	No	Yes	0	6	8
96	R:R:F194	R:R:I190	3.77	Yes	No	9	6	4
97	R:R:F191	R:R:V195	5.24	Yes	No	0	6	6
98	L:L:F11	R:R:F191	5.36	Yes	Yes	0	0	6
99	R:R:N192	R:R:W242	4.52	No	Yes	12	8	8
100	R:R:N192	R:R:Y268	8.14	No	Yes	12	8	8
101	L:L:F11	R:R:N192	7.25	Yes	No	0	0	8
102	R:R:F194	R:R:Y193	6.19	Yes	Yes	0	6	8
103	R:R:T197	R:R:Y193	8.74	No	Yes	0	8	8
104	R:R:F236	R:R:Y193	9.28	No	Yes	0	4	8
105	R:R:I239	R:R:Y193	6.04	No	Yes	0	7	8
106	R:R:V196	R:R:Y268	3.79	No	Yes	0	6	8
107	R:R:T197	R:R:W232	6.06	No	No	0	8	9
108	R:R:M202	R:R:N198	5.61	No	Yes	0	9	8
109	R:R:F199	R:R:I272	16.33	Yes	No	2	8	7
110	R:R:F199	R:R:L276	4.87	Yes	No	0	8	7
111	R:R:F199	R:R:Y323	5.16	Yes	Yes	2	8	9
112	L:L:I7	R:R:F199	3.77	Yes	Yes	2	0	8
113	R:R:F200	R:R:P235	4.33	No	No	0	5	9
114	R:R:V204	R:R:W201	6.13	No	Yes	0	7	9
115	R:R:G231	R:R:W201	8.44	No	Yes	0	8	9
116	R:R:W201	R:R:W232	13.12	Yes	No	1	9	9
117	R:R:M202	R:R:Q351	5.44	No	Yes	0	9	9
118	R:R:F203	R:R:V275	9.18	No	No	0	7	7
119	R:R:F203	R:R:I278	5.02	No	No	0	7	5
120	R:R:F227	R:R:V204	6.55	Yes	No	0	7	7
121	R:R:E205	R:R:L318	7.95	Yes	Yes	4	9	8
122	R:R:F227	R:R:Y208	7.22	Yes	Yes	1	7	7
123	R:R:I213	R:R:L209	4.28	No	No	13	7	8
124	R:R:I286	R:R:L209	4.28	No	No	13	8	8
125	R:R:H210	R:R:V214	16.61	Yes	No	0	8	6
126	R:R:F282	R:R:H210	27.15	No	Yes	0	7	8
127	R:R:H210	R:R:N285	8.93	Yes	Yes	0	8	6
128	R:R:L222	R:R:T211	4.42	No	No	0	4	7
129	R:R:I213	R:R:I286	5.89	No	No	13	7	8
130	R:R:I289	R:R:V214	4.61	Yes	No	0	7	6
131	R:R:T216	R:R:Y217	3.75	No	No	0	7	7
132	R:R:F227	R:R:L222	12.18	Yes	No	0	7	4
133	R:R:I230	R:R:L226	4.28	No	No	0	4	3
134	R:R:C233	R:R:F229	6.98	No	No	0	7	3
135	R:R:F229	R:R:I234	6.28	No	No	0	3	3
136	R:R:I230	R:R:I234	4.42	No	No	0	4	3
137	R:R:I234	R:R:P235	3.39	No	No	0	3	9
138	R:R:K246	R:R:W242	6.96	Yes	Yes	0	5	8
139	R:R:I267	R:R:W242	4.7	No	Yes	0	7	8
140	R:R:W242	R:R:Y268	9.65	Yes	Yes	12	8	8
141	R:R:K246	R:R:W255	10.44	Yes	Yes	0	5	9
142	R:R:K246	R:R:V264	9.11	Yes	No	0	5	4
143	R:R:D265	R:R:K246	5.53	No	Yes	0	6	5
144	R:R:L247	R:R:N251	4.12	No	No	5	1	5
145	R:R:L247	R:R:W255	5.69	No	Yes	5	1	9
146	R:R:E250	R:R:E252	3.81	No	Yes	0	6	3
147	R:R:D262	R:R:E250	10.39	No	No	0	4	6
148	R:R:N251	R:R:W255	6.78	No	Yes	5	5	9
149	R:R:E252	R:R:Q253	3.82	Yes	Yes	11	3	4
150	R:R:E252	R:R:E259	3.81	Yes	No	11	3	3
151	R:R:G257	R:R:Q253	4.93	No	Yes	0	5	4
152	R:R:E259	R:R:Q253	5.1	No	Yes	11	3	4
153	L:L:F11	R:R:F256	10.72	Yes	Yes	0	0	7
154	L:L:R15	R:R:F256	5.34	No	Yes	0	0	7
155	R:R:D265	R:R:K258	6.91	No	No	0	6	5
156	L:L:R15	R:R:K258	4.95	No	No	0	0	5
157	R:R:E259	R:R:P260	4.72	No	No	0	3	5
158	R:R:D262	R:R:V264	4.38	No	No	0	4	4
159	R:R:L263	R:R:Y266	3.52	No	No	0	3	6
160	R:R:D265	R:R:Y268	3.45	No	Yes	0	6	8
161	R:R:Q269	R:R:Y268	10.15	Yes	Yes	0	6	8
162	L:L:I7	R:R:Q269	5.49	Yes	Yes	0	0	6
163	L:L:D8	R:R:Q269	7.83	No	Yes	0	0	6
164	R:R:G270	R:R:P271	4.06	No	No	0	5	9
165	L:L:I7	R:R:I272	5.89	Yes	No	2	0	7
166	R:R:I278	R:R:L274	4.28	No	No	0	5	3
167	R:R:F282	R:R:I278	5.02	No	No	0	7	5
168	R:R:L283	R:R:L319	4.15	Yes	No	0	7	8
169	R:R:I321	R:R:L283	4.28	No	Yes	0	6	7
170	R:R:N285	R:R:R288	3.62	Yes	No	0	6	6
171	R:R:T312	R:R:V287	6.35	No	No	0	7	6
172	R:R:I289	R:R:R288	5.01	Yes	No	0	7	6
173	R:R:L290	R:R:L294	4.15	No	No	0	7	6
174	R:R:R295	R:R:T292	5.17	No	No	0	4	6
175	R:R:L294	R:R:Q304	5.32	No	No	0	6	5
176	R:R:K307	R:R:L294	4.23	No	No	0	6	6
177	R:R:Q304	R:R:R295	4.67	No	No	0	5	4
178	R:R:I303	R:R:S300	9.29	No	No	0	5	6
179	R:R:F358	R:R:V314	9.18	No	No	0	7	7
180	R:R:F354	R:R:P317	4.33	No	No	0	6	7
181	R:R:L318	R:R:Y359	16.41	Yes	No	4	8	8
182	R:R:T322	R:R:Y323	3.75	Yes	Yes	2	8	9
183	R:R:L347	R:R:T322	8.84	No	Yes	0	5	8
184	R:R:Q351	R:R:T322	4.25	Yes	Yes	2	9	8
185	R:R:Q348	R:R:Y323	7.89	No	Yes	0	8	9
186	R:R:Q351	R:R:Y323	7.89	Yes	Yes	2	9	9
187	R:R:F326	R:R:N329	7.25	No	Yes	3	8	5
188	R:R:F326	R:R:F340	7.5	No	Yes	3	8	7
189	R:R:F327	R:R:V328	5.24	No	No	0	5	5
190	L:L:L5	R:R:F327	7.31	No	No	0	0	5
191	R:R:N329	R:R:P330	6.52	Yes	No	0	5	5
192	R:R:N329	R:R:S336	4.47	Yes	No	0	5	3
193	R:R:F340	R:R:N329	10.87	Yes	Yes	3	7	5
194	R:R:E332	R:R:P330	4.72	No	No	0	4	5
195	R:R:D333	R:R:S336	8.83	No	No	0	4	3
196	R:R:F340	R:R:Q337	5.86	Yes	No	0	7	4
197	R:R:I338	R:R:Y342	4.84	No	No	0	3	6
198	R:R:F340	R:R:I341	3.77	Yes	No	0	7	6
199	R:R:F340	R:R:N344	8.46	Yes	No	3	7	8
200	L:L:L9	R:R:F340	3.65	No	Yes	3	0	7
201	R:R:F343	R:R:L347	6.09	No	No	0	4	5
202	L:L:S6	R:R:N344	8.94	No	No	0	0	8
203	L:L:L9	R:R:N344	5.49	No	No	3	0	8
204	R:R:F346	R:R:F350	6.43	No	Yes	0	6	6
205	L:L:T10	R:R:Q348	4.25	No	No	0	0	8
206	R:R:F350	R:R:S349	7.93	Yes	No	7	6	9
207	R:R:F353	R:R:F354	4.29	Yes	No	0	5	6
208	R:R:F353	R:R:V357	7.87	Yes	No	0	5	5
209	R:R:F361	R:R:V357	5.24	No	No	0	6	5
210	R:R:F358	R:R:Y359	16.5	No	No	0	7	8
211	R:R:C360	R:R:F361	6.98	No	No	0	7	6
212	R:R:F362	R:R:R367	5.34	No	No	0	5	7
213	R:R:E365	R:R:N363	13.15	No	No	0	8	9
214	R:R:N363	R:R:V366	5.91	No	No	0	9	8
215	R:R:R371	R:R:S368	3.95	No	No	0	5	4
216	R:R:W374	R:R:W377	6.56	No	No	0	4	4
217	R:R:Q378	R:R:R384	15.19	Yes	No	0	6	3
218	R:R:D379	R:R:R384	5.96	No	No	0	2	3
219	R:R:H381	R:R:L383	6.43	No	No	0	5	4
220	R:R:P386	R:R:V385	3.53	No	No	0	4	3
221	L:L:I7	L:L:L5	4.28	Yes	No	0	0	0
222	L:L:D8	L:L:F11	3.58	No	Yes	0	0	0
223	L:L:H12	L:L:R15	3.39	No	No	0	0	0
224	L:L:H12	L:L:T16	4.11	No	No	0	0	0
225	L:L:L14	L:L:L18	6.92	No	No	0	0	0
226	L:L:R27	L:L:T23	6.47	No	No	0	0	0
227	L:L:Q24	L:L:R27	4.67	No	No	0	0	0
228	L:L:E28	L:L:Q24	3.82	No	No	0	0	0
229	L:L:E28	L:L:E31	8.88	No	No	0	0	0
230	L:L:I35	L:L:Q32	9.61	No	No	0	0	0
231	L:L:F37	L:L:R34	5.34	No	No	0	0	0
232	R:R:F350	R:R:F354	3.22	Yes	No	0	6	6
233	R:R:V172	R:R:V176	3.21	No	Yes	0	4	2
234	R:R:I230	R:R:V204	3.07	No	No	0	4	7
235	R:R:I244	R:R:V240	3.07	No	No	0	4	3
236	R:R:I303	R:R:T298	3.04	No	No	0	5	5
237	R:R:N120	R:R:S349	2.98	No	No	0	7	9
238	R:R:L283	R:R:V287	2.98	Yes	No	0	7	6
239	R:R:L313	R:R:V309	2.98	No	No	0	6	6
240	R:R:L318	R:R:V355	2.98	Yes	No	0	8	9
241	R:R:N279	R:R:V275	2.96	No	No	0	9	7
242	R:R:L325	R:R:T322	2.95	No	Yes	0	6	8
243	R:R:I213	R:R:I289	2.94	No	Yes	0	7	7
244	R:R:I303	R:R:K307	2.91	No	No	0	5	6
245	R:R:F200	R:R:P271	2.89	No	No	0	5	9
246	R:R:I144	R:R:L141	2.85	No	Yes	0	7	6
247	R:R:I321	R:R:L316	2.85	No	No	0	6	7
248	R:R:L276	R:R:M324	2.83	No	No	0	7	5
249	L:L:I36	L:L:N33	2.83	No	No	0	0	0
250	R:R:C225	R:R:R223	2.79	No	No	0	3	5
251	R:R:C254	R:R:F256	2.79	No	Yes	0	9	7
252	L:L:P3	R:R:Y266	2.78	No	No	0	0	6
253	R:R:L283	R:R:L315	2.77	Yes	No	0	7	9
254	L:L:L13	R:R:N120	2.75	No	No	0	0	7
255	R:R:L319	R:R:N279	2.75	No	No	0	8	9
256	R:R:M291	R:R:Q304	2.72	No	No	0	4	5
257	R:R:D333	R:R:L335	2.71	No	No	0	4	3
258	R:R:L383	R:R:Q378	2.66	No	Yes	0	4	6
259	R:R:F353	R:R:S127	2.64	Yes	No	0	5	9
260	L:L:S4	R:R:F340	2.64	No	Yes	0	0	7
261	R:R:E252	R:R:N180	2.63	Yes	No	0	3	5
262	R:R:H210	R:R:M215	2.63	Yes	No	0	8	4
263	R:R:F362	R:R:V357	2.62	No	No	0	5	5
264	R:R:F200	R:R:I238	2.51	No	No	0	5	7
265	R:R:F280	R:R:I321	2.51	No	No	0	5	6
266	R:R:T219	R:R:Y208	2.5	No	Yes	0	5	7
267	R:R:L111	R:R:R114	2.43	No	No	0	1	2
268	R:R:L141	R:R:R373	2.43	Yes	No	0	6	4
269	R:R:Q269	R:R:Y266	2.25	Yes	No	0	6	6
270	R:R:R373	R:R:R376	2.13	No	No	0	4	5
271	R:R:Y248	R:R:Y249	1.99	No	No	0	1	4
272	R:R:G245	R:R:V264	1.84	No	No	0	4	4
273	R:R:G320	R:R:M202	1.75	No	No	0	9	9
274	R:R:A116	R:R:S345	1.71	No	No	0	7	6
275	R:R:G123	R:R:L122	1.71	No	No	0	8	6
276	R:R:G206	R:R:L319	1.71	No	No	0	8	8
277	R:R:G364	R:R:N363	1.7	No	No	0	5	9
278	R:R:C207	R:R:T211	1.69	No	No	0	5	7
279	R:R:C186	R:R:I190	1.64	No	No	0	4	4
280	R:R:E205	R:R:G206	1.64	Yes	No	0	9	8
281	R:R:L316	R:R:P317	1.64	No	No	0	7	7
282	R:R:G331	R:R:Q337	1.64	No	No	0	3	4
283	L:L:N2	L:L:P3	1.63	No	No	0	0	0
284	R:R:A308	R:R:M291	1.61	No	No	0	7	4
285	R:R:V128	R:R:V132	1.6	No	No	0	6	3
286	R:R:S218	R:R:T211	1.6	No	No	0	5	7
287	R:R:S297	R:R:T298	1.6	No	No	0	4	5
288	R:R:S300	R:R:T302	1.6	No	No	0	6	5
289	R:R:A311	R:R:L290	1.58	No	No	0	8	7
290	L:L:A30	L:L:N33	1.56	No	No	0	0	0
291	R:R:I160	R:R:V164	1.54	No	No	0	7	4
292	R:R:M339	R:R:S336	1.53	No	No	0	4	3
293	R:R:K310	R:R:V314	1.52	No	No	0	7	7
294	R:R:L136	R:R:V132	1.49	No	No	0	2	3
295	R:R:L137	R:R:V370	1.49	No	No	0	8	4
296	R:R:L141	R:R:V370	1.49	Yes	No	0	6	4
297	R:R:L168	R:R:V164	1.49	No	No	0	4	4
298	R:R:N154	R:R:V150	1.48	Yes	No	0	8	5
299	R:R:N285	R:R:V281	1.48	Yes	No	0	6	3
300	R:R:D379	R:R:V385	1.46	No	No	0	2	3
301	R:R:I289	R:R:K293	1.45	Yes	No	0	7	7
302	R:R:F236	R:R:P237	1.44	No	No	0	4	4
303	R:R:I273	R:R:L277	1.43	No	No	0	4	3
304	L:L:L5	R:R:I273	1.43	No	No	0	0	4
305	R:R:K224	R:R:L147	1.41	No	Yes	0	5	6
306	R:R:E301	R:R:T302	1.41	No	No	0	5	5
307	R:R:C125	R:R:F167	1.4	No	No	0	5	6
308	R:R:A133	R:R:F361	1.39	No	No	0	4	6
309	R:R:L313	R:R:L316	1.38	No	No	0	6	7
310	L:L:L17	L:L:L20	1.38	No	No	0	0	0
311	L:L:D1	L:L:N2	1.35	No	No	0	0	0
312	R:R:D333	R:R:D334	1.33	No	No	0	4	5
313	L:L:R29	L:L:S25	1.32	No	No	0	0	0
314	R:R:A243	R:R:W242	1.3	No	Yes	0	4	8
315	R:R:A243	R:R:W255	1.3	No	Yes	0	4	9
316	R:R:H375	R:R:Q378	1.24	No	Yes	0	4	6
317	R:R:I244	R:R:Y248	1.21	No	No	0	4	1
318	R:R:F284	R:R:N285	1.21	No	Yes	0	5	6
319	R:R:M291	R:R:Y305	1.2	No	No	0	4	5
320	R:R:L247	R:R:Y248	1.17	No	No	0	1	1
321	L:L:R22	R:R:H174	1.13	No	No	0	0	2
322	R:R:Q378	R:R:W374	1.1	Yes	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L141	2.875	4	0	6
2	R:R:L147	5.7125	4	1	6
3	R:R:I151	5.1125	4	1	8
4	R:R:H152	6.8975	4	4	8
5	R:R:W153	6.506	5	8	6
6	R:R:N154	6.2025	4	0	8
7	R:R:T158	5.1175	4	1	8
8	R:R:F159	9.9325	4	0	9
9	R:R:M165	4.415	4	9	5
10	R:R:W166	10.4667	6	6	7
11	R:R:V176	5.14	5	10	2
12	R:R:F191	5	5	0	6
13	R:R:Y193	7.5625	4	0	8
14	R:R:F194	7.685	4	9	6
15	R:R:N198	10.5375	4	0	8
16	R:R:F199	7.5325	4	2	8
17	R:R:W201	8.64167	6	1	9
18	R:R:E205	7.58	4	4	9
19	R:R:Y208	5.6925	4	1	7
20	R:R:H210	13.83	4	0	8
21	R:R:F227	7.162	5	1	7
22	R:R:W242	5.12833	6	12	8
23	R:R:K246	8.01	4	0	5
24	R:R:E252	3.5175	4	11	3
25	R:R:Q253	7.48	4	11	4
26	R:R:W255	9.84	5	5	9
27	R:R:F256	5.226	5	0	7
28	R:R:Y268	7.036	5	12	8
29	R:R:Q269	6.43	4	0	6
30	R:R:L283	3.545	4	0	7
31	R:R:N285	3.81	4	0	6
32	R:R:I289	3.5025	4	0	7
33	R:R:L318	7.8	4	4	8
34	R:R:T322	4.9475	4	2	8
35	R:R:Y323	6.1725	4	2	9
36	R:R:N329	7.2775	4	3	5
37	R:R:F340	6.10714	7	3	7
38	R:R:F350	6.2775	4	7	6
39	R:R:Q351	5.86	4	2	9
40	R:R:F353	5.01	4	0	5
41	R:R:Q378	5.0475	4	0	6
42	L:L:I7	4.8575	4	2	0
43	L:L:F11	6.7275	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T16	R:R:Y113	31.8038	12.48	No	No	0	0	4
2	R:R:Y109	R:R:Y113	30.5639	9.93	No	No	0	3	4
3	R:R:Q337	R:R:Y109	24.2529	6.76	No	No	0	4	3
4	R:R:F340	R:R:Q337	21.6765	5.86	Yes	No	0	7	4
5	R:R:F340	R:R:N329	12.3919	10.87	Yes	Yes	3	7	5
6	L:L:H12	L:L:T16	35.4791	4.11	No	No	0	0	0
7	L:L:H12	L:L:R15	36.6893	3.39	No	No	0	0	0
8	L:L:R15	R:R:F256	34.6475	5.34	No	Yes	0	0	7
9	L:L:F11	R:R:F256	59.1343	10.72	Yes	Yes	0	0	7
10	L:L:F11	R:R:F191	78.9991	5.36	Yes	Yes	0	0	6
11	R:R:F191	R:R:W166	17.682	7.02	Yes	Yes	0	6	7
12	R:R:F191	R:R:V195	80.447	5.24	Yes	No	0	6	6
13	R:R:R162	R:R:V195	80.8145	9.15	No	No	0	8	6
14	R:R:N198	R:R:R162	93.5368	7.23	Yes	No	0	8	8
15	R:R:N198	R:R:T158	68.534	8.77	Yes	Yes	0	8	8
16	R:R:L155	R:R:T158	50.2209	4.42	No	Yes	0	8	8
17	R:R:E205	R:R:L155	100	14.58	Yes	No	0	9	8
18	R:R:E205	R:R:G206	67.0416	1.64	Yes	No	0	9	8
19	R:R:G206	R:R:L319	65.6977	1.71	No	No	0	8	8
20	R:R:L283	R:R:L319	39.1655	4.15	Yes	No	0	7	8
21	R:R:I321	R:R:L283	33.3482	4.28	No	Yes	0	6	7
22	R:R:I321	R:R:L316	30.4488	2.85	No	No	0	6	7
23	R:R:L316	R:R:P317	26.161	1.64	No	No	0	7	7
24	R:R:F354	R:R:P317	24.7541	4.33	No	No	0	6	7
25	R:R:F350	R:R:F354	15.0648	3.22	Yes	No	0	6	6
26	R:R:F159	R:R:N198	38.345	20.54	Yes	Yes	0	9	8
27	R:R:F159	R:R:L155	59.6132	7.31	Yes	No	0	9	8
28	R:R:H124	R:R:W166	11.5974	21.16	No	Yes	0	6	7
29	R:R:F353	R:R:F354	10.7956	4.29	Yes	No	0	5	6
30	R:R:T158	R:R:W201	47.5406	3.64	Yes	Yes	1	8	9
31	R:R:N154	R:R:W201	21.747	15.82	Yes	Yes	0	8	9
32	R:R:N154	R:R:W153	18.5618	3.39	Yes	Yes	0	8	6
33	R:R:F135	R:R:W153	14.3669	11.02	No	Yes	8	5	6
34	R:R:F135	R:R:I160	13.4982	3.77	No	No	0	5	7
35	R:R:I160	R:R:L131	10.5802	4.28	No	No	0	7	9
36	R:R:E205	R:R:H152	28.923	6.15	Yes	Yes	4	9	8
37	R:R:H152	R:R:R148	21.6765	4.51	Yes	No	0	8	8
38	R:R:E365	R:R:R148	18.714	5.82	No	No	0	8	8
39	R:R:E365	R:R:I144	13.0972	6.83	No	No	0	8	7
40	R:R:I144	R:R:L141	10.2758	2.85	No	Yes	0	7	6
41	R:R:I151	R:R:W201	12.0652	4.7	Yes	Yes	1	8	9
42	R:R:V204	R:R:W201	19.282	6.13	No	Yes	0	7	9
43	L:L:T10	R:R:W166	16.765	4.85	No	Yes	0	0	7
44	L:L:T10	R:R:Q348	17.4555	4.25	No	No	0	0	8
45	R:R:Q348	R:R:Y323	11.7496	7.89	No	Yes	0	8	9
46	R:R:Q351	R:R:Y323	31.299	7.89	Yes	Yes	2	9	9
47	R:R:Q348	R:R:R162	16.5349	4.67	No	No	0	8	8
48	L:L:I7	R:R:Q269	26.6882	5.49	Yes	Yes	0	0	6
49	L:L:I7	R:R:F199	29.1458	3.77	Yes	Yes	2	0	8
50	R:R:F199	R:R:Y323	32.279	5.16	Yes	Yes	2	8	9
51	R:R:Q269	R:R:Y268	17.6412	10.15	Yes	Yes	0	6	8
52	R:R:F159	R:R:Q351	30.7904	5.86	Yes	Yes	0	9	9
53	R:R:C254	R:R:F256	18.4133	2.79	No	Yes	0	9	7
54	R:R:C184	R:R:C254	17.1437	7.28	No	No	0	9	9
55	R:R:C184	R:R:V176	15.8667	3.42	No	Yes	0	9	2
56	R:R:F256	R:R:H177	12.3176	3.39	Yes	No	0	7	2
57	R:R:K246	R:R:W255	15.8258	10.44	Yes	Yes	0	5	9
58	L:L:F11	R:R:N192	25.4743	7.25	Yes	No	0	0	8
59	R:R:N192	R:R:W242	23.3842	4.52	No	Yes	12	8	8
60	R:R:K246	R:R:W242	16.7762	6.96	Yes	Yes	0	5	8
61	R:R:I230	R:R:V204	12.4698	3.07	No	No	0	4	7
62	R:R:I230	R:R:I234	10.0345	4.42	No	No	0	4	3
63	R:R:L319	R:R:N279	29.465	2.75	No	No	0	8	9
64	R:R:N279	R:R:V275	27.891	2.96	No	No	0	9	7
65	R:R:F203	R:R:V275	26.3095	9.18	No	No	0	7	7
66	R:R:F203	R:R:I278	24.7206	5.02	No	No	0	7	5
67	R:R:F282	R:R:I278	21.5206	5.02	No	No	0	7	5
68	R:R:F282	R:R:H210	19.9094	27.15	No	Yes	0	7	8
69	R:R:H210	R:R:V214	10.0085	16.61	Yes	No	0	8	6
70	R:R:L247	R:R:W255	16.6091	5.69	No	Yes	5	1	9
71	R:R:L247	R:R:Y248	13.3311	1.17	No	No	0	1	1
72	R:R:A243	R:R:W242	12.5441	1.3	No	Yes	0	4	8
73	R:R:A243	R:R:W255	10.9849	1.3	No	Yes	0	4	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R27	R:R:Q106	8.18	0	No	No	0	2	0	1
L:L:T16	R:R:R107	5.17	0	No	No	0	1	0	1
L:L:E19	R:R:R107	6.98	0	No	No	0	1	0	1
R:R:Y109	R:R:Y113	9.93	0	No	No	3	4	2	1
R:R:Q337	R:R:Y109	6.76	0	No	No	4	3	2	2
L:L:T16	R:R:Y113	12.48	0	No	No	0	4	0	1
R:R:L117	R:R:Y121	9.38	0	No	No	4	5	1	2
L:L:L17	R:R:L117	4.15	0	No	No	0	4	0	1
R:R:N120	R:R:S345	8.94	0	No	No	7	6	1	2
R:R:W166	R:R:Y121	3.86	6	Yes	No	7	5	1	2
R:R:Q170	R:R:Y121	14.65	6	No	No	6	5	2	2
R:R:H124	R:R:W166	21.16	0	No	Yes	6	7	2	1
R:R:R162	R:R:V195	9.15	0	No	No	8	6	2	2
R:R:Q348	R:R:R162	4.67	0	No	No	8	8	1	2
R:R:F191	R:R:M165	3.73	0	Yes	Yes	6	5	1	2
R:R:F167	R:R:W166	4.01	0	No	Yes	6	7	2	1
R:R:Q170	R:R:W166	21.9	6	No	Yes	6	7	2	1
R:R:F191	R:R:W166	7.02	0	Yes	Yes	6	7	1	1
L:L:T10	R:R:W166	4.85	0	No	Yes	0	7	0	1
R:R:F191	R:R:L169	3.65	0	Yes	No	6	6	1	2
R:R:E175	R:R:H174	9.85	0	No	No	1	2	2	1
L:L:S25	R:R:H174	5.58	0	No	No	0	2	0	1
R:R:H177	R:R:Q253	16.07	0	No	Yes	2	4	1	2
R:R:F256	R:R:H177	3.39	0	Yes	No	7	2	1	1
L:L:L18	R:R:H177	3.86	0	No	No	0	2	0	1
L:L:R22	R:R:E178	10.47	0	No	No	0	3	0	1
R:R:F256	R:R:T188	3.89	0	Yes	No	7	7	1	2
R:R:F191	R:R:V195	5.24	0	Yes	No	6	6	1	2
L:L:F11	R:R:F191	5.36	0	Yes	Yes	0	6	0	1
R:R:N192	R:R:W242	4.52	12	No	Yes	8	8	1	2
R:R:N192	R:R:Y268	8.14	12	No	Yes	8	8	1	2
L:L:F11	R:R:N192	7.25	0	Yes	No	0	8	0	1
R:R:F199	R:R:I272	16.33	2	Yes	No	8	7	1	1
R:R:F199	R:R:L276	4.87	2	Yes	No	8	7	1	2
R:R:F199	R:R:Y323	5.16	2	Yes	Yes	8	9	1	2
L:L:I7	R:R:F199	3.77	2	Yes	Yes	0	8	0	1
R:R:W242	R:R:Y268	9.65	12	Yes	Yes	8	8	2	2
L:L:F11	R:R:F256	10.72	0	Yes	Yes	0	7	0	1
L:L:R15	R:R:F256	5.34	0	No	Yes	0	7	0	1
R:R:D265	R:R:K258	6.91	0	No	No	6	5	2	1
L:L:R15	R:R:K258	4.95	0	No	No	0	5	0	1
R:R:L263	R:R:Y266	3.52	0	No	No	3	6	2	1
R:R:D265	R:R:Y268	3.45	0	No	Yes	6	8	2	2
R:R:Q269	R:R:Y268	10.15	0	Yes	Yes	6	8	1	2
L:L:I7	R:R:Q269	5.49	2	Yes	Yes	0	6	0	1
L:L:D8	R:R:Q269	7.83	0	No	Yes	0	6	0	1
L:L:I7	R:R:I272	5.89	2	Yes	No	0	7	0	1
R:R:Q348	R:R:Y323	7.89	0	No	Yes	8	9	1	2
R:R:F326	R:R:N329	7.25	3	No	Yes	8	5	2	2
R:R:F326	R:R:F340	7.5	3	No	Yes	8	7	2	1
R:R:F327	R:R:V328	5.24	0	No	No	5	5	1	2
L:L:L5	R:R:F327	7.31	0	No	No	0	5	0	1
R:R:F340	R:R:N329	10.87	3	Yes	Yes	7	5	1	2
R:R:F340	R:R:Q337	5.86	3	Yes	No	7	4	1	2
R:R:F340	R:R:I341	3.77	3	Yes	No	7	6	1	2
R:R:F340	R:R:N344	8.46	3	Yes	No	7	8	1	1
L:L:L9	R:R:F340	3.65	3	No	Yes	0	7	0	1
L:L:S6	R:R:N344	8.94	0	No	No	0	8	0	1
L:L:L9	R:R:N344	5.49	3	No	No	0	8	0	1
L:L:T10	R:R:Q348	4.25	0	No	No	0	8	0	1
R:R:N120	R:R:S349	2.98	0	No	No	7	9	1	2
R:R:C254	R:R:F256	2.79	0	No	Yes	9	7	2	1
L:L:P3	R:R:Y266	2.78	0	No	No	0	6	0	1
L:L:L13	R:R:N120	2.75	0	No	No	0	7	0	1
L:L:S4	R:R:F340	2.64	0	No	Yes	0	7	0	1
R:R:Q269	R:R:Y266	2.25	0	Yes	No	6	6	1	1
R:R:I273	R:R:L277	1.43	0	No	No	4	3	1	2
L:L:L5	R:R:I273	1.43	0	No	No	0	4	0	1
L:L:R22	R:R:H174	1.13	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6PB1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	298
Number of Links	322
Number of Hubs	43
Number of Links mediated by Hubs	153
Number of Communities	13
Number of Nodes involved in Communities	50
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	55968
Length Of Smallest Path	3
Average Path Length	14.5631
Length of Longest Path	33
Minimum Path Strength	1.17
Average Path Strength	6.51462
Maximum Path Strength	21.88
Minimum Path Correlation	0.7
Average Path Correlation	0.958623
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	65.5059
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6578
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • cellular process • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of biological process • long-term synaptic potentiation • synaptic signaling • regulation of biological quality • positive regulation of cellular process • regulation of synaptic plasticity • trans-synaptic signaling • regulation of signaling • cell-cell signaling • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse • distal axon • cell junction • neuron projection terminus • molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • G protein-coupled receptor binding • hormone receptor binding • neuropeptide receptor binding • deacetylase activity • enzyme regulator activity • protein lysine deacetylase activity • catalytic activity, acting on a protein • deacylase activity • enzyme inhibitor activity • histone deacetylase activity • molecular function inhibitor activity • histone deacetylase inhibitor activity • histone deacetylase regulator activity • catalytic activity • corticotropin-releasing hormone receptor 1 binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • regulation of growth • regulation of cellular component organization • growth • positive regulation of biological process • positive regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • positive regulation of growth • cellular component organization or biogenesis • positive regulation of cellular process • multicellular organismal process • response to stress • multicellular organismal response to stress • response to pain • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of biological process • negative regulation of appetite • regulation of response to food • regulation of response to stimulus • response to food • response to chemical • regulation of biological quality • regulation of appetite • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • aerobic respiration • cellular respiration • energy derivation by oxidation of organic compounds • metabolic process • generation of precursor metabolites and energy • interleukin-6 production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-6 production • regulation of interleukin-6 production • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of defense response • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • regulation of response to stress • behavioral fear response • defense response • positive regulation of behavioral fear response • behavior • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of DNA replication • regulation of primary metabolic process • nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • DNA metabolic process • nucleic acid metabolic process • DNA replication • positive regulation of DNA metabolic process • regulation of DNA metabolic process • regulation of DNA replication • regulation of localization • regulation of hormone secretion • negative regulation of signaling • transport • negative regulation of transport • hormone secretion • negative regulation of cell communication • localization • negative regulation of secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to endogenous stimulus • response to glucocorticoid • drinking behavior • feeding behavior • positive regulation of protein metabolic process • positive regulation of translation • post-transcriptional regulation of gene expression • protein metabolic process • regulation of protein metabolic process • translation • regulation of translation • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • startle response • nervous system process • neuromuscular process • response to external stimulus • response to auditory stimulus • response to mechanical stimulus • response to abiotic stimulus • positive regulation of cell communication • nitrogen compound transport • regulation of system process • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • positive regulation of peptide hormone secretion • endocrine hormone secretion • regulation of endocrine process • regulation of peptide secretion • positive regulation of secretion by cell • regulation of corticotropin secretion • peptide secretion • positive regulation of hormone secretion • positive regulation of secretion • amide transport • positive regulation of peptide secretion • corticotropin secretion • regulation of peptide transport • peptide transport • endocrine process • positive regulation of transport • peptide hormone secretion • positive regulation of signaling • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • sensory perception • sensory perception of sound • sensory perception of mechanical stimulus • regulation of vascular permeability • positive regulation of vascular permeability • biological process involved in intraspecies interaction between organisms • social behavior • learning • learning or memory • cognition • associative learning • trans-synaptic signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • response to oxidative stress • negative regulation of feeding behavior • negative regulation of behavior • regulation of feeding behavior • negative regulation of multicellular organismal process • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • positive regulation of DNA-templated transcription • RNA metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • system development • negative regulation of cell size • regulation of cellular component size • regulation of cell size • heart process • regulation of heart contraction • positive regulation of blood circulation • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of heart contraction • regulation of blood circulation • regulation of striated muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • heart contraction • response to estradiol • response to oxygen-containing compound • regulation of blood pressure • negative regulation of blood pressure • cell body • perikaryon • neuronal cell body • main axon • varicosity • extracellular region • D2 dopamine receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • establishment of protein localization • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • protein localization to extracellular region • regulation of establishment of protein localization • regulation of protein transport • protein transport • regulation of insulin secretion • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13324
Sequence	>6PB1_nogp_Chain_R Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L R S I R C L R N V I H W N L I T T F I L R N V M W F L L Q L V D H E V H E S N E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M T Y S T E R L R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E N E Q C W F G K E P G D L V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V N P G E D D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R S A V R K R W H R W Q D H H S L R V P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TRY	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-G11)/β1/γ2	3.7	2022-11-09	10.1038/s41467-022-33851-3
	7TRY (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		3.7	2022-11-09	10.1038/s41467-022-33851-3
	7TS0	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1L-Go)/β1/γ2	2.8	2022-11-09	10.1038/s41467-022-33851-3
	7TS0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2022-11-09	10.1038/s41467-022-33851-3
	6PB1	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	2.8	2020-02-12	10.1016/j.molcel.2020.01.013
	6PB1 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2020-02-12	10.1016/j.molcel.2020.01.013

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