psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R27	R:R:Q106	8.18	No	No	0	0	2
2	L:L:T16	R:R:R107	5.17	No	No	0	0	1
3	L:L:E19	R:R:R107	6.98	No	No	0	0	1
4	R:R:D334	R:R:K108	12.44	No	No	0	5	3
5	R:R:H112	R:R:Y109	5.44	No	No	0	4	3
6	R:R:Y109	R:R:Y113	9.93	No	No	0	3	4
7	R:R:Q337	R:R:Y109	6.76	No	No	0	4	3
8	R:R:D110	R:R:L111	6.79	No	No	0	3	1
9	R:R:H112	R:R:I338	10.61	No	No	0	4	3
10	L:L:T16	R:R:Y113	12.48	No	No	0	0	4
11	R:R:I115	R:R:Y342	8.46	No	No	0	4	6
12	R:R:L117	R:R:Y121	9.38	No	No	0	4	5
13	L:L:L17	R:R:L117	4.15	No	No	0	0	4
14	R:R:N120	R:R:S345	8.94	No	No	0	7	6
15	R:R:W166	R:R:Y121	3.86	Yes	No	6	7	5
16	R:R:Q170	R:R:Y121	14.65	No	No	6	6	5
17	R:R:G123	R:R:S349	3.71	No	No	7	8	9
18	R:R:F350	R:R:G123	7.53	Yes	No	7	6	8
19	R:R:H124	R:R:N163	11.48	No	No	0	6	7
20	R:R:H124	R:R:W166	21.16	No	Yes	0	6	7
21	R:R:F353	R:R:V126	5.24	Yes	No	0	5	5
22	R:R:N163	R:R:V128	4.43	No	No	0	7	6
23	R:R:A130	R:R:S356	3.42	No	No	0	6	8
24	R:R:I156	R:R:L131	5.71	No	No	0	7	9
25	R:R:I160	R:R:L131	4.28	No	No	0	7	9
26	R:R:L131	R:R:S356	4.5	No	No	0	9	8
27	R:R:A134	R:R:S356	3.42	No	No	0	8	8
28	R:R:A134	R:R:C360	3.61	No	No	0	8	7
29	R:R:F135	R:R:L139	6.09	No	No	8	5	2
30	R:R:F135	R:R:W153	11.02	No	Yes	8	5	6
31	R:R:F135	R:R:I160	3.77	No	No	0	5	7
32	R:R:C360	R:R:L137	4.76	No	No	0	7	8
33	R:R:F138	R:R:W153	4.01	No	Yes	0	7	6
34	R:R:L139	R:R:W153	6.83	No	Yes	8	2	6
35	R:R:A369	R:R:L141	4.73	No	Yes	0	7	6
36	R:R:R142	R:R:R145	7.46	No	No	0	7	6
37	R:R:I144	R:R:N149	9.91	No	No	0	7	7
38	R:R:E365	R:R:I144	6.83	No	No	0	8	7
39	R:R:C146	R:R:R148	5.57	No	No	0	7	8
40	R:R:I151	R:R:L147	7.14	Yes	Yes	1	8	6
41	R:R:L147	R:R:Y208	8.21	Yes	Yes	1	6	7
42	R:R:F227	R:R:L147	6.09	Yes	Yes	1	7	6
43	R:R:H152	R:R:R148	4.51	Yes	No	0	8	8
44	R:R:E365	R:R:R148	5.82	No	No	0	8	8
45	R:R:I151	R:R:W201	4.7	Yes	Yes	1	8	9
46	R:R:I151	R:R:Y208	4.84	Yes	Yes	1	8	7
47	R:R:F227	R:R:I151	3.77	Yes	Yes	1	7	8
48	R:R:E205	R:R:H152	6.15	Yes	Yes	4	9	8
49	R:R:H152	R:R:L318	3.86	Yes	Yes	4	8	8
50	R:R:H152	R:R:Y359	13.07	Yes	No	4	8	8
51	R:R:N154	R:R:W153	3.39	Yes	Yes	0	8	6
52	R:R:T157	R:R:W153	7.28	No	Yes	0	3	6
53	R:R:N154	R:R:W201	15.82	Yes	Yes	0	8	9
54	R:R:L228	R:R:N154	4.12	No	Yes	0	5	8
55	R:R:L155	R:R:T158	4.42	No	Yes	0	8	8
56	R:R:F159	R:R:L155	7.31	Yes	No	0	9	8
57	R:R:E205	R:R:L155	14.58	Yes	No	0	9	8
58	R:R:N198	R:R:T158	8.77	Yes	Yes	0	8	8
59	R:R:T158	R:R:W201	3.64	Yes	Yes	1	8	9
60	R:R:T158	R:R:W232	3.64	Yes	No	1	8	9
61	R:R:F159	R:R:N198	20.54	Yes	Yes	0	9	8
62	R:R:F159	R:R:Q351	5.86	Yes	Yes	0	9	9
63	R:R:F159	R:R:G352	6.02	Yes	No	0	9	9
64	R:R:F194	R:R:L161	17.05	Yes	No	0	6	5
65	R:R:R162	R:R:V195	9.15	No	No	0	8	6
66	R:R:N198	R:R:R162	7.23	Yes	No	0	8	8
67	R:R:Q348	R:R:R162	4.67	No	No	0	8	8
68	R:R:I187	R:R:M165	4.37	No	Yes	0	6	5
69	R:R:I190	R:R:M165	5.83	No	Yes	9	4	5
70	R:R:F191	R:R:M165	3.73	Yes	Yes	0	6	5
71	R:R:F194	R:R:M165	3.73	Yes	Yes	9	6	5
72	R:R:F167	R:R:W166	4.01	No	Yes	0	6	7
73	R:R:Q170	R:R:W166	21.9	No	Yes	6	6	7
74	R:R:F191	R:R:W166	7.02	Yes	Yes	0	6	7
75	L:L:T10	R:R:W166	4.85	No	Yes	0	0	7
76	R:R:I187	R:R:L169	4.28	No	No	0	6	6
77	R:R:F191	R:R:L169	3.65	Yes	No	0	6	6
78	R:R:D173	R:R:E175	5.2	No	No	0	3	1
79	R:R:D173	R:R:V176	4.38	No	Yes	0	3	2
80	R:R:E175	R:R:H174	9.85	No	No	0	1	2
81	L:L:S25	R:R:H174	5.58	No	No	0	0	2
82	R:R:E181	R:R:V176	8.56	No	Yes	10	3	2
83	R:R:V176	R:R:W183	6.13	Yes	No	10	2	1
84	R:R:C184	R:R:V176	3.42	No	Yes	0	9	2
85	R:R:H177	R:R:Q253	16.07	No	Yes	0	2	4
86	R:R:F256	R:R:H177	3.39	Yes	No	0	7	2
87	L:L:L18	R:R:H177	3.86	No	No	0	0	2
88	L:L:R22	R:R:E178	10.47	No	No	0	0	3
89	R:R:E181	R:R:S179	4.31	No	No	0	3	1
90	R:R:E181	R:R:W183	14.17	No	No	10	3	1
91	R:R:C184	R:R:C254	7.28	No	No	0	9	9
92	R:R:N251	R:R:R185	9.64	No	No	5	5	6
93	R:R:R185	R:R:W255	24.99	No	Yes	5	6	9
94	R:R:F256	R:R:T188	3.89	Yes	No	0	7	7
95	R:R:T189	R:R:W242	3.64	No	Yes	0	6	8
96	R:R:F194	R:R:I190	3.77	Yes	No	9	6	4
97	R:R:F191	R:R:V195	5.24	Yes	No	0	6	6
98	L:L:F11	R:R:F191	5.36	Yes	Yes	0	0	6
99	R:R:N192	R:R:W242	4.52	No	Yes	12	8	8
100	R:R:N192	R:R:Y268	8.14	No	Yes	12	8	8
101	L:L:F11	R:R:N192	7.25	Yes	No	0	0	8
102	R:R:F194	R:R:Y193	6.19	Yes	Yes	0	6	8
103	R:R:T197	R:R:Y193	8.74	No	Yes	0	8	8
104	R:R:F236	R:R:Y193	9.28	No	Yes	0	4	8
105	R:R:I239	R:R:Y193	6.04	No	Yes	0	7	8
106	R:R:V196	R:R:Y268	3.79	No	Yes	0	6	8
107	R:R:T197	R:R:W232	6.06	No	No	0	8	9
108	R:R:M202	R:R:N198	5.61	No	Yes	0	9	8
109	R:R:F199	R:R:I272	16.33	Yes	No	2	8	7
110	R:R:F199	R:R:L276	4.87	Yes	No	0	8	7
111	R:R:F199	R:R:Y323	5.16	Yes	Yes	2	8	9
112	L:L:I7	R:R:F199	3.77	Yes	Yes	2	0	8
113	R:R:F200	R:R:P235	4.33	No	No	0	5	9
114	R:R:V204	R:R:W201	6.13	No	Yes	0	7	9
115	R:R:G231	R:R:W201	8.44	No	Yes	0	8	9
116	R:R:W201	R:R:W232	13.12	Yes	No	1	9	9
117	R:R:M202	R:R:Q351	5.44	No	Yes	0	9	9
118	R:R:F203	R:R:V275	9.18	No	No	0	7	7
119	R:R:F203	R:R:I278	5.02	No	No	0	7	5
120	R:R:F227	R:R:V204	6.55	Yes	No	0	7	7
121	R:R:E205	R:R:L318	7.95	Yes	Yes	4	9	8
122	R:R:F227	R:R:Y208	7.22	Yes	Yes	1	7	7
123	R:R:I213	R:R:L209	4.28	No	No	13	7	8
124	R:R:I286	R:R:L209	4.28	No	No	13	8	8
125	R:R:H210	R:R:V214	16.61	Yes	No	0	8	6
126	R:R:F282	R:R:H210	27.15	No	Yes	0	7	8
127	R:R:H210	R:R:N285	8.93	Yes	Yes	0	8	6
128	R:R:L222	R:R:T211	4.42	No	No	0	4	7
129	R:R:I213	R:R:I286	5.89	No	No	13	7	8
130	R:R:I289	R:R:V214	4.61	Yes	No	0	7	6
131	R:R:T216	R:R:Y217	3.75	No	No	0	7	7
132	R:R:F227	R:R:L222	12.18	Yes	No	0	7	4
133	R:R:I230	R:R:L226	4.28	No	No	0	4	3
134	R:R:C233	R:R:F229	6.98	No	No	0	7	3
135	R:R:F229	R:R:I234	6.28	No	No	0	3	3
136	R:R:I230	R:R:I234	4.42	No	No	0	4	3
137	R:R:I234	R:R:P235	3.39	No	No	0	3	9
138	R:R:K246	R:R:W242	6.96	Yes	Yes	0	5	8
139	R:R:I267	R:R:W242	4.7	No	Yes	0	7	8
140	R:R:W242	R:R:Y268	9.65	Yes	Yes	12	8	8
141	R:R:K246	R:R:W255	10.44	Yes	Yes	0	5	9
142	R:R:K246	R:R:V264	9.11	Yes	No	0	5	4
143	R:R:D265	R:R:K246	5.53	No	Yes	0	6	5
144	R:R:L247	R:R:N251	4.12	No	No	5	1	5
145	R:R:L247	R:R:W255	5.69	No	Yes	5	1	9
146	R:R:E250	R:R:E252	3.81	No	Yes	0	6	3
147	R:R:D262	R:R:E250	10.39	No	No	0	4	6
148	R:R:N251	R:R:W255	6.78	No	Yes	5	5	9
149	R:R:E252	R:R:Q253	3.82	Yes	Yes	11	3	4
150	R:R:E252	R:R:E259	3.81	Yes	No	11	3	3
151	R:R:G257	R:R:Q253	4.93	No	Yes	0	5	4
152	R:R:E259	R:R:Q253	5.1	No	Yes	11	3	4
153	L:L:F11	R:R:F256	10.72	Yes	Yes	0	0	7
154	L:L:R15	R:R:F256	5.34	No	Yes	0	0	7
155	R:R:D265	R:R:K258	6.91	No	No	0	6	5
156	L:L:R15	R:R:K258	4.95	No	No	0	0	5
157	R:R:E259	R:R:P260	4.72	No	No	0	3	5
158	R:R:D262	R:R:V264	4.38	No	No	0	4	4
159	R:R:L263	R:R:Y266	3.52	No	No	0	3	6
160	R:R:D265	R:R:Y268	3.45	No	Yes	0	6	8
161	R:R:Q269	R:R:Y268	10.15	Yes	Yes	0	6	8
162	L:L:I7	R:R:Q269	5.49	Yes	Yes	0	0	6
163	L:L:D8	R:R:Q269	7.83	No	Yes	0	0	6
164	R:R:G270	R:R:P271	4.06	No	No	0	5	9
165	L:L:I7	R:R:I272	5.89	Yes	No	2	0	7
166	R:R:I278	R:R:L274	4.28	No	No	0	5	3
167	R:R:F282	R:R:I278	5.02	No	No	0	7	5
168	R:R:L283	R:R:L319	4.15	Yes	No	0	7	8
169	R:R:I321	R:R:L283	4.28	No	Yes	0	6	7
170	R:R:N285	R:R:R288	3.62	Yes	No	0	6	6
171	R:R:T312	R:R:V287	6.35	No	No	0	7	6
172	R:R:I289	R:R:R288	5.01	Yes	No	0	7	6
173	R:R:L290	R:R:L294	4.15	No	No	0	7	6
174	R:R:R295	R:R:T292	5.17	No	No	0	4	6
175	R:R:L294	R:R:Q304	5.32	No	No	0	6	5
176	R:R:K307	R:R:L294	4.23	No	No	0	6	6
177	R:R:Q304	R:R:R295	4.67	No	No	0	5	4
178	R:R:I303	R:R:S300	9.29	No	No	0	5	6
179	R:R:F358	R:R:V314	9.18	No	No	0	7	7
180	R:R:F354	R:R:P317	4.33	No	No	0	6	7
181	R:R:L318	R:R:Y359	16.41	Yes	No	4	8	8
182	R:R:T322	R:R:Y323	3.75	Yes	Yes	2	8	9
183	R:R:L347	R:R:T322	8.84	No	Yes	0	5	8
184	R:R:Q351	R:R:T322	4.25	Yes	Yes	2	9	8
185	R:R:Q348	R:R:Y323	7.89	No	Yes	0	8	9
186	R:R:Q351	R:R:Y323	7.89	Yes	Yes	2	9	9
187	R:R:F326	R:R:N329	7.25	No	Yes	3	8	5
188	R:R:F326	R:R:F340	7.5	No	Yes	3	8	7
189	R:R:F327	R:R:V328	5.24	No	No	0	5	5
190	L:L:L5	R:R:F327	7.31	No	No	0	0	5
191	R:R:N329	R:R:P330	6.52	Yes	No	0	5	5
192	R:R:N329	R:R:S336	4.47	Yes	No	0	5	3
193	R:R:F340	R:R:N329	10.87	Yes	Yes	3	7	5
194	R:R:E332	R:R:P330	4.72	No	No	0	4	5
195	R:R:D333	R:R:S336	8.83	No	No	0	4	3
196	R:R:F340	R:R:Q337	5.86	Yes	No	0	7	4
197	R:R:I338	R:R:Y342	4.84	No	No	0	3	6
198	R:R:F340	R:R:I341	3.77	Yes	No	0	7	6
199	R:R:F340	R:R:N344	8.46	Yes	No	3	7	8
200	L:L:L9	R:R:F340	3.65	No	Yes	3	0	7
201	R:R:F343	R:R:L347	6.09	No	No	0	4	5
202	L:L:S6	R:R:N344	8.94	No	No	0	0	8
203	L:L:L9	R:R:N344	5.49	No	No	3	0	8
204	R:R:F346	R:R:F350	6.43	No	Yes	0	6	6
205	L:L:T10	R:R:Q348	4.25	No	No	0	0	8
206	R:R:F350	R:R:S349	7.93	Yes	No	7	6	9
207	R:R:F353	R:R:F354	4.29	Yes	No	0	5	6
208	R:R:F353	R:R:V357	7.87	Yes	No	0	5	5
209	R:R:F361	R:R:V357	5.24	No	No	0	6	5
210	R:R:F358	R:R:Y359	16.5	No	No	0	7	8
211	R:R:C360	R:R:F361	6.98	No	No	0	7	6
212	R:R:F362	R:R:R367	5.34	No	No	0	5	7
213	R:R:E365	R:R:N363	13.15	No	No	0	8	9
214	R:R:N363	R:R:V366	5.91	No	No	0	9	8
215	R:R:R371	R:R:S368	3.95	No	No	0	5	4
216	R:R:W374	R:R:W377	6.56	No	No	0	4	4
217	R:R:Q378	R:R:R384	15.19	Yes	No	0	6	3
218	R:R:D379	R:R:R384	5.96	No	No	0	2	3
219	R:R:H381	R:R:L383	6.43	No	No	0	5	4
220	R:R:P386	R:R:V385	3.53	No	No	0	4	3
221	L:L:I7	L:L:L5	4.28	Yes	No	0	0	0
222	L:L:D8	L:L:F11	3.58	No	Yes	0	0	0
223	L:L:H12	L:L:R15	3.39	No	No	0	0	0
224	L:L:H12	L:L:T16	4.11	No	No	0	0	0
225	L:L:L14	L:L:L18	6.92	No	No	0	0	0
226	L:L:R27	L:L:T23	6.47	No	No	0	0	0
227	L:L:Q24	L:L:R27	4.67	No	No	0	0	0
228	L:L:E28	L:L:Q24	3.82	No	No	0	0	0
229	L:L:E28	L:L:E31	8.88	No	No	0	0	0
230	L:L:I35	L:L:Q32	9.61	No	No	0	0	0
231	L:L:F37	L:L:R34	5.34	No	No	0	0	0
232	R:R:F350	R:R:F354	3.22	Yes	No	0	6	6
233	R:R:V172	R:R:V176	3.21	No	Yes	0	4	2
234	R:R:I230	R:R:V204	3.07	No	No	0	4	7
235	R:R:I244	R:R:V240	3.07	No	No	0	4	3
236	R:R:I303	R:R:T298	3.04	No	No	0	5	5
237	R:R:N120	R:R:S349	2.98	No	No	0	7	9
238	R:R:L283	R:R:V287	2.98	Yes	No	0	7	6
239	R:R:L313	R:R:V309	2.98	No	No	0	6	6
240	R:R:L318	R:R:V355	2.98	Yes	No	0	8	9
241	R:R:N279	R:R:V275	2.96	No	No	0	9	7
242	R:R:L325	R:R:T322	2.95	No	Yes	0	6	8
243	R:R:I213	R:R:I289	2.94	No	Yes	0	7	7
244	R:R:I303	R:R:K307	2.91	No	No	0	5	6
245	R:R:F200	R:R:P271	2.89	No	No	0	5	9
246	R:R:I144	R:R:L141	2.85	No	Yes	0	7	6
247	R:R:I321	R:R:L316	2.85	No	No	0	6	7
248	R:R:L276	R:R:M324	2.83	No	No	0	7	5
249	L:L:I36	L:L:N33	2.83	No	No	0	0	0
250	R:R:C225	R:R:R223	2.79	No	No	0	3	5
251	R:R:C254	R:R:F256	2.79	No	Yes	0	9	7
252	L:L:P3	R:R:Y266	2.78	No	No	0	0	6
253	R:R:L283	R:R:L315	2.77	Yes	No	0	7	9
254	L:L:L13	R:R:N120	2.75	No	No	0	0	7
255	R:R:L319	R:R:N279	2.75	No	No	0	8	9
256	R:R:M291	R:R:Q304	2.72	No	No	0	4	5
257	R:R:D333	R:R:L335	2.71	No	No	0	4	3
258	R:R:L383	R:R:Q378	2.66	No	Yes	0	4	6
259	R:R:F353	R:R:S127	2.64	Yes	No	0	5	9
260	L:L:S4	R:R:F340	2.64	No	Yes	0	0	7
261	R:R:E252	R:R:N180	2.63	Yes	No	0	3	5
262	R:R:H210	R:R:M215	2.63	Yes	No	0	8	4
263	R:R:F362	R:R:V357	2.62	No	No	0	5	5
264	R:R:F200	R:R:I238	2.51	No	No	0	5	7
265	R:R:F280	R:R:I321	2.51	No	No	0	5	6
266	R:R:T219	R:R:Y208	2.5	No	Yes	0	5	7
267	R:R:L111	R:R:R114	2.43	No	No	0	1	2
268	R:R:L141	R:R:R373	2.43	Yes	No	0	6	4
269	R:R:Q269	R:R:Y266	2.25	Yes	No	0	6	6
270	R:R:R373	R:R:R376	2.13	No	No	0	4	5
271	R:R:Y248	R:R:Y249	1.99	No	No	0	1	4
272	R:R:G245	R:R:V264	1.84	No	No	0	4	4
273	R:R:G320	R:R:M202	1.75	No	No	0	9	9
274	R:R:A116	R:R:S345	1.71	No	No	0	7	6
275	R:R:G123	R:R:L122	1.71	No	No	0	8	6
276	R:R:G206	R:R:L319	1.71	No	No	0	8	8
277	R:R:G364	R:R:N363	1.7	No	No	0	5	9
278	R:R:C207	R:R:T211	1.69	No	No	0	5	7
279	R:R:C186	R:R:I190	1.64	No	No	0	4	4
280	R:R:E205	R:R:G206	1.64	Yes	No	0	9	8
281	R:R:L316	R:R:P317	1.64	No	No	0	7	7
282	R:R:G331	R:R:Q337	1.64	No	No	0	3	4
283	L:L:N2	L:L:P3	1.63	No	No	0	0	0
284	R:R:A308	R:R:M291	1.61	No	No	0	7	4
285	R:R:V128	R:R:V132	1.6	No	No	0	6	3
286	R:R:S218	R:R:T211	1.6	No	No	0	5	7
287	R:R:S297	R:R:T298	1.6	No	No	0	4	5
288	R:R:S300	R:R:T302	1.6	No	No	0	6	5
289	R:R:A311	R:R:L290	1.58	No	No	0	8	7
290	L:L:A30	L:L:N33	1.56	No	No	0	0	0
291	R:R:I160	R:R:V164	1.54	No	No	0	7	4
292	R:R:M339	R:R:S336	1.53	No	No	0	4	3
293	R:R:K310	R:R:V314	1.52	No	No	0	7	7
294	R:R:L136	R:R:V132	1.49	No	No	0	2	3
295	R:R:L137	R:R:V370	1.49	No	No	0	8	4
296	R:R:L141	R:R:V370	1.49	Yes	No	0	6	4
297	R:R:L168	R:R:V164	1.49	No	No	0	4	4
298	R:R:N154	R:R:V150	1.48	Yes	No	0	8	5
299	R:R:N285	R:R:V281	1.48	Yes	No	0	6	3
300	R:R:D379	R:R:V385	1.46	No	No	0	2	3
301	R:R:I289	R:R:K293	1.45	Yes	No	0	7	7
302	R:R:F236	R:R:P237	1.44	No	No	0	4	4
303	R:R:I273	R:R:L277	1.43	No	No	0	4	3
304	L:L:L5	R:R:I273	1.43	No	No	0	0	4
305	R:R:K224	R:R:L147	1.41	No	Yes	0	5	6
306	R:R:E301	R:R:T302	1.41	No	No	0	5	5
307	R:R:C125	R:R:F167	1.4	No	No	0	5	6
308	R:R:A133	R:R:F361	1.39	No	No	0	4	6
309	R:R:L313	R:R:L316	1.38	No	No	0	6	7
310	L:L:L17	L:L:L20	1.38	No	No	0	0	0
311	L:L:D1	L:L:N2	1.35	No	No	0	0	0
312	R:R:D333	R:R:D334	1.33	No	No	0	4	5
313	L:L:R29	L:L:S25	1.32	No	No	0	0	0
314	R:R:A243	R:R:W242	1.3	No	Yes	0	4	8
315	R:R:A243	R:R:W255	1.3	No	Yes	0	4	9
316	R:R:H375	R:R:Q378	1.24	No	Yes	0	4	6
317	R:R:I244	R:R:Y248	1.21	No	No	0	4	1
318	R:R:F284	R:R:N285	1.21	No	Yes	0	5	6
319	R:R:M291	R:R:Y305	1.2	No	No	0	4	5
320	R:R:L247	R:R:Y248	1.17	No	No	0	1	1
321	L:L:R22	R:R:H174	1.13	No	No	0	0	2
322	R:R:Q378	R:R:W374	1.1	Yes	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L141	2.875	4	0	6
2	R:R:L147	5.7125	4	1	6
3	R:R:I151	5.1125	4	1	8
4	R:R:H152	6.8975	4	4	8
5	R:R:W153	6.506	5	8	6
6	R:R:N154	6.2025	4	0	8
7	R:R:T158	5.1175	4	1	8
8	R:R:F159	9.9325	4	0	9
9	R:R:M165	4.415	4	9	5
10	R:R:W166	10.4667	6	6	7
11	R:R:V176	5.14	5	10	2
12	R:R:F191	5	5	0	6
13	R:R:Y193	7.5625	4	0	8
14	R:R:F194	7.685	4	9	6
15	R:R:N198	10.5375	4	0	8
16	R:R:F199	7.5325	4	2	8
17	R:R:W201	8.64167	6	1	9
18	R:R:E205	7.58	4	4	9
19	R:R:Y208	5.6925	4	1	7
20	R:R:H210	13.83	4	0	8
21	R:R:F227	7.162	5	1	7
22	R:R:W242	5.12833	6	12	8
23	R:R:K246	8.01	4	0	5
24	R:R:E252	3.5175	4	11	3
25	R:R:Q253	7.48	4	11	4
26	R:R:W255	9.84	5	5	9
27	R:R:F256	5.226	5	0	7
28	R:R:Y268	7.036	5	12	8
29	R:R:Q269	6.43	4	0	6
30	R:R:L283	3.545	4	0	7
31	R:R:N285	3.81	4	0	6
32	R:R:I289	3.5025	4	0	7
33	R:R:L318	7.8	4	4	8
34	R:R:T322	4.9475	4	2	8
35	R:R:Y323	6.1725	4	2	9
36	R:R:N329	7.2775	4	3	5
37	R:R:F340	6.10714	7	3	7
38	R:R:F350	6.2775	4	7	6
39	R:R:Q351	5.86	4	2	9
40	R:R:F353	5.01	4	0	5
41	R:R:Q378	5.0475	4	0	6
42	L:L:I7	4.8575	4	2	0
43	L:L:F11	6.7275	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T16	R:R:Y113	31.8038	12.48	No	No	0	0	4
2	R:R:Y109	R:R:Y113	30.5639	9.93	No	No	0	3	4
3	R:R:Q337	R:R:Y109	24.2529	6.76	No	No	0	4	3
4	R:R:F340	R:R:Q337	21.6765	5.86	Yes	No	0	7	4
5	R:R:F340	R:R:N329	12.3919	10.87	Yes	Yes	3	7	5
6	L:L:H12	L:L:T16	35.4791	4.11	No	No	0	0	0
7	L:L:H12	L:L:R15	36.6893	3.39	No	No	0	0	0
8	L:L:R15	R:R:F256	34.6475	5.34	No	Yes	0	0	7
9	L:L:F11	R:R:F256	59.1343	10.72	Yes	Yes	0	0	7
10	L:L:F11	R:R:F191	78.9991	5.36	Yes	Yes	0	0	6
11	R:R:F191	R:R:W166	17.682	7.02	Yes	Yes	0	6	7
12	R:R:F191	R:R:V195	80.447	5.24	Yes	No	0	6	6
13	R:R:R162	R:R:V195	80.8145	9.15	No	No	0	8	6
14	R:R:N198	R:R:R162	93.5368	7.23	Yes	No	0	8	8
15	R:R:N198	R:R:T158	68.534	8.77	Yes	Yes	0	8	8
16	R:R:L155	R:R:T158	50.2209	4.42	No	Yes	0	8	8
17	R:R:E205	R:R:L155	100	14.58	Yes	No	0	9	8
18	R:R:E205	R:R:G206	67.0416	1.64	Yes	No	0	9	8
19	R:R:G206	R:R:L319	65.6977	1.71	No	No	0	8	8
20	R:R:L283	R:R:L319	39.1655	4.15	Yes	No	0	7	8
21	R:R:I321	R:R:L283	33.3482	4.28	No	Yes	0	6	7
22	R:R:I321	R:R:L316	30.4488	2.85	No	No	0	6	7
23	R:R:L316	R:R:P317	26.161	1.64	No	No	0	7	7
24	R:R:F354	R:R:P317	24.7541	4.33	No	No	0	6	7
25	R:R:F350	R:R:F354	15.0648	3.22	Yes	No	0	6	6
26	R:R:F159	R:R:N198	38.345	20.54	Yes	Yes	0	9	8
27	R:R:F159	R:R:L155	59.6132	7.31	Yes	No	0	9	8
28	R:R:H124	R:R:W166	11.5974	21.16	No	Yes	0	6	7
29	R:R:F353	R:R:F354	10.7956	4.29	Yes	No	0	5	6
30	R:R:T158	R:R:W201	47.5406	3.64	Yes	Yes	1	8	9
31	R:R:N154	R:R:W201	21.747	15.82	Yes	Yes	0	8	9
32	R:R:N154	R:R:W153	18.5618	3.39	Yes	Yes	0	8	6
33	R:R:F135	R:R:W153	14.3669	11.02	No	Yes	8	5	6
34	R:R:F135	R:R:I160	13.4982	3.77	No	No	0	5	7
35	R:R:I160	R:R:L131	10.5802	4.28	No	No	0	7	9
36	R:R:E205	R:R:H152	28.923	6.15	Yes	Yes	4	9	8
37	R:R:H152	R:R:R148	21.6765	4.51	Yes	No	0	8	8
38	R:R:E365	R:R:R148	18.714	5.82	No	No	0	8	8
39	R:R:E365	R:R:I144	13.0972	6.83	No	No	0	8	7
40	R:R:I144	R:R:L141	10.2758	2.85	No	Yes	0	7	6
41	R:R:I151	R:R:W201	12.0652	4.7	Yes	Yes	1	8	9
42	R:R:V204	R:R:W201	19.282	6.13	No	Yes	0	7	9
43	L:L:T10	R:R:W166	16.765	4.85	No	Yes	0	0	7
44	L:L:T10	R:R:Q348	17.4555	4.25	No	No	0	0	8
45	R:R:Q348	R:R:Y323	11.7496	7.89	No	Yes	0	8	9
46	R:R:Q351	R:R:Y323	31.2952	7.89	Yes	Yes	2	9	9
47	R:R:Q348	R:R:R162	16.5349	4.67	No	No	0	8	8
48	L:L:I7	R:R:Q269	26.6882	5.49	Yes	Yes	0	0	6
49	L:L:I7	R:R:F199	29.1458	3.77	Yes	Yes	2	0	8
50	R:R:F199	R:R:Y323	32.2753	5.16	Yes	Yes	2	8	9
51	R:R:Q269	R:R:Y268	17.6412	10.15	Yes	Yes	0	6	8
52	R:R:F159	R:R:Q351	30.7904	5.86	Yes	Yes	0	9	9
53	R:R:C254	R:R:F256	18.4133	2.79	No	Yes	0	9	7
54	R:R:C184	R:R:C254	17.1437	7.28	No	No	0	9	9
55	R:R:C184	R:R:V176	15.8667	3.42	No	Yes	0	9	2
56	R:R:F256	R:R:H177	12.3176	3.39	Yes	No	0	7	2
57	R:R:K246	R:R:W255	15.8258	10.44	Yes	Yes	0	5	9
58	L:L:F11	R:R:N192	25.4743	7.25	Yes	No	0	0	8
59	R:R:N192	R:R:W242	23.3842	4.52	No	Yes	12	8	8
60	R:R:K246	R:R:W242	16.7762	6.96	Yes	Yes	0	5	8
61	R:R:I230	R:R:V204	12.4698	3.07	No	No	0	4	7
62	R:R:I230	R:R:I234	10.0345	4.42	No	No	0	4	3
63	R:R:L319	R:R:N279	29.465	2.75	No	No	0	8	9
64	R:R:N279	R:R:V275	27.891	2.96	No	No	0	9	7
65	R:R:F203	R:R:V275	26.3095	9.18	No	No	0	7	7
66	R:R:F203	R:R:I278	24.7206	5.02	No	No	0	7	5
67	R:R:F282	R:R:I278	21.5206	5.02	No	No	0	7	5
68	R:R:F282	R:R:H210	19.9094	27.15	No	Yes	0	7	8
69	R:R:H210	R:R:V214	10.0085	16.61	Yes	No	0	8	6
70	R:R:L247	R:R:W255	16.6091	5.69	No	Yes	5	1	9
71	R:R:L247	R:R:Y248	13.3311	1.17	No	No	0	1	1
72	R:R:A243	R:R:W242	12.5441	1.3	No	Yes	0	4	8
73	R:R:A243	R:R:W255	10.9849	1.3	No	Yes	0	4	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R27	R:R:Q106	8.18	0	No	No	0	2	0	1
L:L:T16	R:R:R107	5.17	0	No	No	0	1	0	1
L:L:E19	R:R:R107	6.98	0	No	No	0	1	0	1
R:R:Y109	R:R:Y113	9.93	0	No	No	3	4	2	1
R:R:Q337	R:R:Y109	6.76	0	No	No	4	3	2	2
L:L:T16	R:R:Y113	12.48	0	No	No	0	4	0	1
R:R:L117	R:R:Y121	9.38	0	No	No	4	5	1	2
L:L:L17	R:R:L117	4.15	0	No	No	0	4	0	1
R:R:N120	R:R:S345	8.94	0	No	No	7	6	1	2
R:R:W166	R:R:Y121	3.86	6	Yes	No	7	5	1	2
R:R:Q170	R:R:Y121	14.65	6	No	No	6	5	2	2
R:R:H124	R:R:W166	21.16	0	No	Yes	6	7	2	1
R:R:R162	R:R:V195	9.15	0	No	No	8	6	2	2
R:R:Q348	R:R:R162	4.67	0	No	No	8	8	1	2
R:R:F191	R:R:M165	3.73	0	Yes	Yes	6	5	1	2
R:R:F167	R:R:W166	4.01	0	No	Yes	6	7	2	1
R:R:Q170	R:R:W166	21.9	6	No	Yes	6	7	2	1
R:R:F191	R:R:W166	7.02	0	Yes	Yes	6	7	1	1
L:L:T10	R:R:W166	4.85	0	No	Yes	0	7	0	1
R:R:F191	R:R:L169	3.65	0	Yes	No	6	6	1	2
R:R:E175	R:R:H174	9.85	0	No	No	1	2	2	1
L:L:S25	R:R:H174	5.58	0	No	No	0	2	0	1
R:R:H177	R:R:Q253	16.07	0	No	Yes	2	4	1	2
R:R:F256	R:R:H177	3.39	0	Yes	No	7	2	1	1
L:L:L18	R:R:H177	3.86	0	No	No	0	2	0	1
L:L:R22	R:R:E178	10.47	0	No	No	0	3	0	1
R:R:F256	R:R:T188	3.89	0	Yes	No	7	7	1	2
R:R:F191	R:R:V195	5.24	0	Yes	No	6	6	1	2
L:L:F11	R:R:F191	5.36	0	Yes	Yes	0	6	0	1
R:R:N192	R:R:W242	4.52	12	No	Yes	8	8	1	2
R:R:N192	R:R:Y268	8.14	12	No	Yes	8	8	1	2
L:L:F11	R:R:N192	7.25	0	Yes	No	0	8	0	1
R:R:F199	R:R:I272	16.33	2	Yes	No	8	7	1	1
R:R:F199	R:R:L276	4.87	2	Yes	No	8	7	1	2
R:R:F199	R:R:Y323	5.16	2	Yes	Yes	8	9	1	2
L:L:I7	R:R:F199	3.77	2	Yes	Yes	0	8	0	1
R:R:W242	R:R:Y268	9.65	12	Yes	Yes	8	8	2	2
L:L:F11	R:R:F256	10.72	0	Yes	Yes	0	7	0	1
L:L:R15	R:R:F256	5.34	0	No	Yes	0	7	0	1
R:R:D265	R:R:K258	6.91	0	No	No	6	5	2	1
L:L:R15	R:R:K258	4.95	0	No	No	0	5	0	1
R:R:L263	R:R:Y266	3.52	0	No	No	3	6	2	1
R:R:D265	R:R:Y268	3.45	0	No	Yes	6	8	2	2
R:R:Q269	R:R:Y268	10.15	0	Yes	Yes	6	8	1	2
L:L:I7	R:R:Q269	5.49	2	Yes	Yes	0	6	0	1
L:L:D8	R:R:Q269	7.83	0	No	Yes	0	6	0	1
L:L:I7	R:R:I272	5.89	2	Yes	No	0	7	0	1
R:R:Q348	R:R:Y323	7.89	0	No	Yes	8	9	1	2
R:R:F326	R:R:N329	7.25	3	No	Yes	8	5	2	2
R:R:F326	R:R:F340	7.5	3	No	Yes	8	7	2	1
R:R:F327	R:R:V328	5.24	0	No	No	5	5	1	2
L:L:L5	R:R:F327	7.31	0	No	No	0	5	0	1
R:R:F340	R:R:N329	10.87	3	Yes	Yes	7	5	1	2
R:R:F340	R:R:Q337	5.86	3	Yes	No	7	4	1	2
R:R:F340	R:R:I341	3.77	3	Yes	No	7	6	1	2
R:R:F340	R:R:N344	8.46	3	Yes	No	7	8	1	1
L:L:L9	R:R:F340	3.65	3	No	Yes	0	7	0	1
L:L:S6	R:R:N344	8.94	0	No	No	0	8	0	1
L:L:L9	R:R:N344	5.49	3	No	No	0	8	0	1
L:L:T10	R:R:Q348	4.25	0	No	No	0	8	0	1
R:R:N120	R:R:S349	2.98	0	No	No	7	9	1	2
R:R:C254	R:R:F256	2.79	0	No	Yes	9	7	2	1
L:L:P3	R:R:Y266	2.78	0	No	No	0	6	0	1
L:L:L13	R:R:N120	2.75	0	No	No	0	7	0	1
L:L:S4	R:R:F340	2.64	0	No	Yes	0	7	0	1
R:R:Q269	R:R:Y266	2.25	0	Yes	No	6	6	1	1
R:R:I273	R:R:L277	1.43	0	No	No	4	3	1	2
L:L:L5	R:R:I273	1.43	0	No	No	0	4	0	1
L:L:R22	R:R:H174	1.13	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6PB1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	298
Number of Links	322
Number of Hubs	43
Number of Links mediated by Hubs	153
Number of Communities	13
Number of Nodes involved in Communities	50
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	55967
Length Of Smallest Path	3
Average Path Length	14.5633
Length of Longest Path	33
Minimum Path Strength	1.17
Average Path Strength	6.51463
Maximum Path Strength	21.88
Minimum Path Correlation	0.7
Average Path Correlation	0.958834
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	65.4526
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6572
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • cellular process • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of biological process • long-term synaptic potentiation • synaptic signaling • regulation of biological quality • positive regulation of cellular process • regulation of synaptic plasticity • trans-synaptic signaling • regulation of signaling • cell-cell signaling • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse • distal axon • cell junction • neuron projection terminus • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation • hormone activity • neuropeptide hormone activity • neuropeptide activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • hormone receptor binding • neuropeptide receptor binding • histone deacetylase inhibitor activity • histone deacetylase regulator activity • corticotropin-releasing hormone receptor 1 binding • regulation of growth • positive regulation of cell growth • regulation of cell growth • cell growth • positive regulation of growth • multicellular organismal response to stress • response to pain • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of appetite • regulation of response to food • response to food • regulation of appetite • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • aerobic respiration • cellular respiration • energy derivation by oxidation of organic compounds • generation of precursor metabolites and energy • interleukin-6 production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-6 production • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • positive regulation of macromolecule metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • behavioral fear response • positive regulation of behavioral fear response • behavior • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of DNA replication • nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • DNA metabolic process • nucleic acid metabolic process • DNA replication • positive regulation of DNA metabolic process • regulation of DNA metabolic process • regulation of DNA replication • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • response to corticosteroid • response to steroid hormone • response to glucocorticoid • drinking behavior • feeding behavior • positive regulation of protein metabolic process • positive regulation of translation • protein biosynthetic process • post-transcriptional regulation of gene expression • protein metabolic process • regulation of protein metabolic process • translation • regulation of translation • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • startle response • response to auditory stimulus • response to mechanical stimulus • positive regulation of corticotropin secretion • endocrine hormone secretion • regulation of endocrine process • regulation of corticotropin secretion • corticotropin secretion • endocrine process • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • sensory perception of sound • sensory perception of mechanical stimulus • regulation of vascular permeability • positive regulation of vascular permeability • biological process involved in intraspecies interaction between organisms • social behavior • learning • learning or memory • associative learning • trans-synaptic signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • response to oxidative stress • negative regulation of feeding behavior • negative regulation of behavior • regulation of feeding behavior • negative regulation of multicellular organismal process • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • positive regulation of DNA-templated transcription • RNA metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron development • negative regulation of cell size • regulation of cellular component size • regulation of cell size • heart process • regulation of heart contraction • positive regulation of blood circulation • positive regulation of cardiac muscle contraction • cardiac muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • positive regulation of heart contraction • regulation of blood circulation • positive regulation of muscle contraction • heart contraction • response to estradiol • regulation of blood pressure • negative regulation of blood pressure • cell body • perikaryon • neuronal cell body • main axon • varicosity
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13324
Sequence	>6PB1_nogp_Chain_R Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L R S I R C L R N V I H W N L I T T F I L R N V M W F L L Q L V D H E V H E S N E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M T Y S T E R L R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E N E Q C W F G K E P G D L V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V N P G E D D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R S A V R K R W H R W Q D H H S L R V P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Urocortin
UniProt	P55089
Sequence	>6PB1_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6PB1	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	2.8	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	6PB1 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	7TRY	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-G11)/β1/γ2	3.7	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TRY (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		3.7	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TS0	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1L-Go)/β1/γ2	2.8	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TS0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2022-11-09	doi.org/10.1038/s41467-022-33851-3

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