psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N2	L:L:P3	3.26	No	No	0	0	0
2	L:L:N2	R:R:K258	5.6	No	No	0	0	5
3	L:L:I7	L:L:L5	4.28	No	Yes	0	0	0
4	L:L:D8	L:L:L5	5.43	No	Yes	0	0	0
5	L:L:L5	R:R:Q269	3.99	Yes	No	0	0	6
6	L:L:S6	R:R:F340	3.96	No	No	0	0	7
7	L:L:I7	R:R:Y323	3.63	No	Yes	0	0	9
8	L:L:L13	L:L:L9	4.15	No	No	0	0	0
9	L:L:L9	R:R:I341	8.56	No	No	0	0	6
10	L:L:L9	R:R:N344	19.22	No	No	0	0	8
11	L:L:T10	R:R:Q348	5.67	No	No	0	0	8
12	L:L:F11	R:R:F191	4.29	No	No	0	0	6
13	L:L:F11	R:R:F256	5.36	No	Yes	0	0	7
14	L:L:H12	L:L:T16	6.85	No	No	0	0	0
15	L:L:H12	R:R:I341	5.3	No	No	0	0	6
16	L:L:L13	L:L:T16	2.95	No	No	7	0	0
17	L:L:L13	R:R:Y113	15.24	No	No	7	0	4
18	L:L:L14	R:R:F256	3.65	No	Yes	0	0	7
19	L:L:R15	R:R:G257	3	No	No	0	0	5
20	L:L:R15	R:R:K258	6.19	No	No	0	0	5
21	L:L:T16	R:R:Y113	3.75	No	No	7	0	4
22	L:L:L17	R:R:Y113	14.07	No	No	0	0	4
23	L:L:L18	R:R:V172	2.98	Yes	No	0	0	4
24	L:L:L18	R:R:H174	5.14	Yes	Yes	3	0	2
25	L:L:L18	R:R:H177	9	Yes	Yes	3	0	2
26	L:L:L18	R:R:F256	3.65	Yes	Yes	3	0	7
27	L:L:E19	R:R:H174	7.39	No	Yes	0	0	2
28	L:L:Q26	L:L:R22	17.52	No	No	0	0	0
29	L:L:R22	R:R:H174	21.44	No	Yes	3	0	2
30	L:L:R22	R:R:E178	8.14	No	No	3	0	3
31	L:L:T23	R:R:R107	3.88	No	No	0	0	1
32	L:L:Q24	L:L:R27	8.18	No	No	0	0	0
33	L:L:E31	L:L:R27	4.65	No	No	0	0	0
34	L:L:E28	L:L:R29	5.82	No	No	0	0	0
35	L:L:R29	R:R:N69	10.85	No	No	0	0	3
36	L:L:A30	R:R:P100	3.74	No	No	0	0	1
37	L:L:I35	L:L:Q32	5.49	No	No	0	0	0
38	L:L:I36	L:L:Q32	4.12	No	No	0	0	0
39	L:L:N33	R:R:F68	7.25	No	No	0	0	6
40	L:L:N33	R:R:Y95	6.98	No	No	0	0	5
41	L:L:N33	R:R:P100	3.26	No	No	0	0	1
42	L:L:D38	L:L:R34	10.72	No	No	0	0	0
43	L:L:F37	R:R:I93	3.77	No	Yes	0	0	7
44	L:L:F37	R:R:Y95	27.85	No	No	0	0	5
45	L:L:D38	L:L:S39	4.42	No	No	0	0	0
46	R:R:T43	R:R:W89	8.49	No	No	0	5	9
47	R:R:G48	R:R:L44	3.42	No	No	0	7	6
48	R:R:D45	R:R:W51	6.7	No	Yes	4	9	9
49	R:R:D45	R:R:I93	4.2	No	Yes	4	9	7
50	R:R:G48	R:R:I47	3.53	No	No	0	7	6
51	R:R:I47	R:R:T49	6.08	No	No	0	6	4
52	R:R:I47	R:R:P65	3.39	No	No	0	6	8
53	R:R:T49	R:R:W51	9.7	No	Yes	4	4	9
54	R:R:R62	R:R:T49	5.17	No	No	4	4	4
55	R:R:P52	R:R:W51	4.05	No	Yes	0	5	9
56	R:R:R62	R:R:W51	4	No	Yes	4	4	9
57	R:R:R81	R:R:W51	7	No	Yes	4	8	9
58	R:R:I93	R:R:W51	4.7	Yes	Yes	4	7	9
59	R:R:E61	R:R:Y80	17.96	No	No	0	5	4
60	R:R:P63	R:R:R62	8.65	No	No	0	4	4
61	R:R:C64	R:R:Y73	14.79	No	Yes	8	9	4
62	R:R:C64	R:R:C98	7.28	No	Yes	8	9	9
63	R:R:E66	R:R:Y67	4.49	No	No	0	3	5
64	R:R:F68	R:R:N69	14.5	No	No	0	6	3
65	R:R:I101	R:R:K72	5.82	No	No	0	2	1
66	R:R:C98	R:R:Y73	9.41	Yes	Yes	8	9	4
67	R:R:N74	R:R:T76	14.62	No	No	0	5	4
68	R:R:Q97	R:R:R77	11.68	No	Yes	0	7	6
69	R:R:E99	R:R:R77	6.98	No	Yes	0	1	6
70	R:R:E82	R:R:Y80	3.37	No	No	0	5	4
71	R:R:I93	R:R:R81	11.27	Yes	No	4	7	8
72	R:R:L84	R:R:T88	2.95	No	No	0	4	5
73	R:R:N94	R:R:S96	7.45	No	No	0	7	6
74	R:R:C98	R:R:Y95	20.16	Yes	No	0	9	5
75	R:R:H112	R:R:Y109	5.44	No	No	0	4	3
76	R:R:H112	R:R:I338	17.23	No	No	0	4	3
77	R:R:I115	R:R:Y342	3.63	No	No	0	4	6
78	R:R:L122	R:R:V118	4.47	No	No	0	6	4
79	R:R:V119	R:R:Y342	6.31	No	No	0	6	6
80	R:R:F346	R:R:V119	5.24	No	No	0	6	6
81	R:R:N120	R:R:S345	5.96	No	No	0	7	6
82	R:R:N120	R:R:S349	5.96	No	No	0	7	9
83	R:R:L122	R:R:Y121	4.69	No	No	0	6	5
84	R:R:F350	R:R:G123	4.52	No	No	0	6	8
85	R:R:H124	R:R:N163	3.83	No	No	9	6	7
86	R:R:H124	R:R:W166	20.1	No	Yes	9	6	7
87	R:R:H124	R:R:S349	8.37	No	No	0	6	9
88	R:R:F353	R:R:V126	7.87	Yes	No	0	5	5
89	R:R:L131	R:R:S127	3	Yes	No	0	9	9
90	R:R:N163	R:R:V128	5.91	No	No	0	7	6
91	R:R:A130	R:R:F353	4.16	No	Yes	0	6	5
92	R:R:I156	R:R:L131	5.71	No	Yes	10	7	9
93	R:R:F159	R:R:L131	6.09	No	Yes	0	9	9
94	R:R:L131	R:R:S356	6.01	Yes	No	10	9	8
95	R:R:A134	R:R:C360	3.61	No	No	0	8	7
96	R:R:F135	R:R:W153	6.01	No	Yes	0	5	6
97	R:R:L137	R:R:V366	2.98	No	No	0	8	8
98	R:R:L137	R:R:V370	5.96	No	No	0	8	4
99	R:R:F138	R:R:W153	8.02	No	Yes	0	7	6
100	R:R:L141	R:R:S143	9.01	No	No	0	6	5
101	R:R:I144	R:R:L141	5.71	No	No	0	7	6
102	R:R:A369	R:R:L141	6.3	No	No	0	7	6
103	R:R:I144	R:R:N149	11.33	No	No	0	7	7
104	R:R:C146	R:R:N149	7.87	No	No	0	7	7
105	R:R:I151	R:R:L147	4.28	Yes	Yes	1	8	6
106	R:R:L147	R:R:Y208	4.69	Yes	No	1	6	7
107	R:R:K224	R:R:L147	7.05	No	Yes	1	5	6
108	R:R:F227	R:R:L147	4.87	Yes	Yes	1	7	6
109	R:R:N149	R:R:R148	9.64	No	Yes	0	7	8
110	R:R:H152	R:R:R148	6.77	Yes	Yes	1	8	8
111	R:R:R148	R:R:Y208	4.12	Yes	No	1	8	7
112	R:R:N363	R:R:R148	8.44	Yes	Yes	1	9	8
113	R:R:E365	R:R:R148	4.65	No	Yes	1	8	8
114	R:R:K224	R:R:V150	4.55	No	No	1	5	5
115	R:R:F227	R:R:V150	5.24	Yes	No	1	7	5
116	R:R:I151	R:R:V204	4.61	Yes	No	1	8	7
117	R:R:E205	R:R:I151	5.47	Yes	Yes	1	9	8
118	R:R:I151	R:R:Y208	4.84	Yes	No	1	8	7
119	R:R:F227	R:R:I151	10.05	Yes	Yes	1	7	8
120	R:R:E205	R:R:H152	7.39	Yes	Yes	1	9	8
121	R:R:H152	R:R:L318	3.86	Yes	No	1	8	8
122	R:R:H152	R:R:Y359	4.36	Yes	No	1	8	8
123	R:R:N154	R:R:W153	4.52	No	Yes	0	8	6
124	R:R:T157	R:R:W153	6.06	No	Yes	0	3	6
125	R:R:N154	R:R:W201	15.82	No	Yes	1	8	9
126	R:R:F227	R:R:N154	4.83	Yes	No	1	7	8
127	R:R:E205	R:R:L155	5.3	Yes	No	0	9	8
128	R:R:I156	R:R:S356	3.1	No	No	10	7	8
129	R:R:L161	R:R:T157	2.95	No	No	0	5	3
130	R:R:T158	R:R:T197	3.14	No	Yes	1	8	8
131	R:R:N198	R:R:T158	14.62	Yes	No	0	8	8
132	R:R:T158	R:R:W201	3.64	No	Yes	1	8	9
133	R:R:F159	R:R:N198	10.87	No	Yes	0	9	8
134	R:R:F159	R:R:G352	4.52	No	No	0	9	9
135	R:R:F194	R:R:L161	14.61	No	No	0	6	5
136	R:R:R162	R:R:V195	6.54	No	No	0	8	6
137	R:R:N198	R:R:R162	9.64	Yes	No	0	8	8
138	R:R:N163	R:R:W166	4.52	No	Yes	9	7	7
139	R:R:I190	R:R:M165	5.83	No	No	11	4	5
140	R:R:F191	R:R:M165	8.71	No	No	0	6	5
141	R:R:F194	R:R:M165	4.98	No	No	11	6	5
142	R:R:Q170	R:R:W166	13.14	No	Yes	0	6	7
143	R:R:F191	R:R:W166	6.01	No	Yes	0	6	7
144	R:R:I187	R:R:L168	7.14	No	No	0	6	4
145	R:R:I187	R:R:L169	5.71	No	No	0	6	6
146	R:R:V172	R:R:V176	3.21	No	Yes	0	4	2
147	R:R:D173	R:R:E175	9.09	No	No	0	3	1
148	R:R:D173	R:R:V176	4.38	No	Yes	0	3	2
149	R:R:E178	R:R:H174	8.62	No	Yes	3	3	2
150	R:R:V176	R:R:W183	8.58	Yes	Yes	12	2	1
151	R:R:C184	R:R:V176	3.42	No	Yes	12	9	2
152	R:R:H177	R:R:Q253	11.13	Yes	No	3	2	4
153	R:R:F256	R:R:H177	20.36	Yes	Yes	3	7	2
154	R:R:G257	R:R:H177	3.18	No	Yes	3	5	2
155	R:R:E181	R:R:S179	7.19	No	No	0	3	1
156	R:R:N180	R:R:R185	6.03	No	No	2	5	6
157	R:R:N180	R:R:N251	8.17	No	No	2	5	5
158	R:R:N180	R:R:W255	6.78	No	Yes	2	5	9
159	R:R:E181	R:R:W183	7.63	No	Yes	0	3	1
160	R:R:R185	R:R:V182	13.08	No	No	0	6	3
161	R:R:C184	R:R:W183	3.92	No	Yes	12	9	1
162	R:R:I187	R:R:W183	3.52	No	Yes	0	6	1
163	R:R:C184	R:R:C254	7.28	No	No	0	9	9
164	R:R:R185	R:R:W255	21.99	No	Yes	2	6	9
165	R:R:T188	R:R:W255	3.64	No	Yes	0	7	9
166	R:R:I239	R:R:T189	4.56	No	No	0	7	6
167	R:R:A243	R:R:T189	3.36	No	No	0	4	6
168	R:R:T189	R:R:W255	4.85	No	Yes	0	6	9
169	R:R:F194	R:R:I190	6.28	No	No	11	6	4
170	R:R:N192	R:R:V196	4.43	No	No	0	8	6
171	R:R:N192	R:R:W242	6.78	No	Yes	2	8	8
172	R:R:N192	R:R:Y268	15.12	No	No	2	8	8
173	R:R:T197	R:R:Y193	8.74	Yes	Yes	1	8	8
174	R:R:P235	R:R:Y193	9.74	Yes	Yes	1	9	8
175	R:R:F236	R:R:Y193	19.6	No	Yes	0	4	8
176	R:R:I239	R:R:Y193	12.09	No	Yes	0	7	8
177	R:R:F199	R:R:V195	5.24	No	No	0	8	6
178	R:R:I272	R:R:V196	4.61	No	No	0	7	6
179	R:R:T197	R:R:W201	3.64	Yes	Yes	1	8	9
180	R:R:P235	R:R:T197	6.99	Yes	Yes	1	9	8
181	R:R:M202	R:R:N198	5.61	No	Yes	0	9	8
182	R:R:F199	R:R:M202	4.98	No	No	0	8	9
183	R:R:F199	R:R:I272	17.58	No	No	0	8	7
184	R:R:F200	R:R:I234	6.28	No	No	1	5	3
185	R:R:F200	R:R:P235	8.67	No	Yes	1	5	9
186	R:R:F227	R:R:W201	5.01	Yes	Yes	1	7	9
187	R:R:G231	R:R:W201	9.85	No	Yes	0	8	9
188	R:R:W201	R:R:W232	10.31	Yes	No	0	9	9
189	R:R:C207	R:R:F203	8.38	No	No	0	5	7
190	R:R:F203	R:R:V275	9.18	No	No	0	7	7
191	R:R:F227	R:R:V204	3.93	Yes	No	1	7	7
192	R:R:I230	R:R:V204	3.07	No	No	0	4	7
193	R:R:E205	R:R:L318	6.63	Yes	No	1	9	8
194	R:R:I286	R:R:L209	4.28	No	No	0	8	8
195	R:R:L209	R:R:L315	4.15	No	No	5	8	9
196	R:R:L209	R:R:L319	4.15	No	No	5	8	8
197	R:R:H210	R:R:V214	11.07	No	No	0	8	6
198	R:R:F282	R:R:H210	16.97	No	No	0	7	8
199	R:R:H210	R:R:N285	12.75	No	No	0	8	6
200	R:R:T211	R:R:T219	3.14	No	No	0	7	5
201	R:R:A212	R:R:T219	3.36	No	No	0	7	5
202	R:R:I213	R:R:I286	7.36	No	No	0	7	8
203	R:R:I213	R:R:I289	5.89	No	No	0	7	7
204	R:R:M215	R:R:V214	3.04	No	No	0	4	6
205	R:R:M215	R:R:Y217	4.79	No	No	0	4	7
206	R:R:M215	R:R:S218	12.27	No	No	0	4	5
207	R:R:R221	R:R:S218	6.59	No	No	0	4	5
208	R:R:F227	R:R:K224	8.69	Yes	No	1	7	5
209	R:R:F227	R:R:L228	4.87	Yes	No	0	7	5
210	R:R:L228	R:R:W232	5.69	No	No	0	5	9
211	R:R:G231	R:R:I230	3.53	No	No	0	8	4
212	R:R:I230	R:R:I234	4.42	No	No	0	4	3
213	R:R:I234	R:R:P235	3.39	No	Yes	1	3	9
214	R:R:K246	R:R:W242	18.57	Yes	Yes	2	5	8
215	R:R:V264	R:R:W242	7.36	No	Yes	2	4	8
216	R:R:W242	R:R:Y268	26.04	Yes	No	2	8	8
217	R:R:G245	R:R:I244	5.29	No	No	0	4	4
218	R:R:I244	R:R:Y248	15.71	No	No	0	4	1
219	R:R:E250	R:R:K246	10.8	No	Yes	0	6	5
220	R:R:K246	R:R:W255	17.4	Yes	Yes	2	5	9
221	R:R:K246	R:R:V264	10.62	Yes	No	2	5	4
222	R:R:L247	R:R:W255	5.69	No	Yes	0	1	9
223	R:R:V264	R:R:Y249	3.79	No	No	0	4	4
224	R:R:E250	R:R:E259	20.3	No	No	0	6	3
225	R:R:N251	R:R:W255	3.39	No	Yes	2	5	9
226	R:R:G257	R:R:Q253	4.93	No	No	3	5	4
227	R:R:C254	R:R:F256	5.59	No	Yes	0	9	7
228	R:R:E259	R:R:P260	3.14	No	No	0	3	5
229	R:R:D265	R:R:Y266	3.45	No	No	0	6	6
230	R:R:D265	R:R:Y268	6.9	No	No	0	6	8
231	R:R:Q269	R:R:Y266	15.78	No	No	0	6	6
232	R:R:G270	R:R:Q269	4.93	No	No	0	5	6
233	R:R:G270	R:R:P271	4.06	No	No	0	5	9
234	R:R:N279	R:R:V275	2.96	No	No	0	9	7
235	R:R:I278	R:R:V281	3.07	No	No	0	5	3
236	R:R:F282	R:R:I278	7.54	No	No	0	7	5
237	R:R:F282	R:R:N279	3.62	No	No	0	7	9
238	R:R:F280	R:R:L283	3.65	No	Yes	5	5	7
239	R:R:F280	R:R:I321	12.56	No	No	5	5	6
240	R:R:F280	R:R:M324	4.98	No	No	0	5	5
241	R:R:L283	R:R:V287	2.98	Yes	No	0	7	6
242	R:R:L283	R:R:L315	5.54	Yes	No	5	7	9
243	R:R:I321	R:R:L283	4.28	No	Yes	5	6	7
244	R:R:I286	R:R:L290	4.28	No	No	0	8	7
245	R:R:M291	R:R:Q304	5.44	No	No	0	4	5
246	R:R:K293	R:R:S297	7.65	No	No	0	7	4
247	R:R:L294	R:R:Q304	15.97	No	No	0	6	5
248	R:R:I303	R:R:T298	15.2	Yes	No	0	5	5
249	R:R:I303	R:R:S300	4.64	Yes	No	0	5	6
250	R:R:E301	R:R:Y305	15.71	No	No	0	5	5
251	R:R:I303	R:R:T302	3.04	Yes	No	0	5	5
252	R:R:K307	R:R:K310	10.06	Yes	No	0	6	7
253	R:R:L313	R:R:V309	2.98	No	No	0	6	6
254	R:R:K310	R:R:V314	6.07	No	No	0	7	7
255	R:R:F358	R:R:V314	7.87	No	No	0	7	7
256	R:R:V314	R:R:Y359	3.79	No	No	0	7	8
257	R:R:L315	R:R:L319	8.3	No	No	5	9	8
258	R:R:L316	R:R:P317	3.28	Yes	No	0	7	7
259	R:R:I321	R:R:L316	4.28	No	Yes	0	6	7
260	R:R:L316	R:R:T322	8.84	Yes	Yes	0	7	8
261	R:R:L316	R:R:L325	8.3	Yes	No	0	7	6
262	R:R:P317	R:R:V355	3.53	No	No	0	7	9
263	R:R:L318	R:R:Y359	15.24	No	No	1	8	8
264	R:R:T322	R:R:Y323	3.75	Yes	Yes	6	8	9
265	R:R:L347	R:R:T322	11.79	No	Yes	0	5	8
266	R:R:Q351	R:R:T322	5.67	No	Yes	6	9	8
267	R:R:Q348	R:R:Y323	4.51	No	Yes	0	8	9
268	R:R:Q351	R:R:Y323	14.65	No	Yes	6	9	9
269	R:R:F327	R:R:M324	9.95	No	No	0	5	5
270	R:R:F326	R:R:F343	9.65	No	No	0	8	4
271	R:R:F340	R:R:Q337	8.2	No	No	0	7	4
272	R:R:I341	R:R:Q337	8.23	No	No	0	6	4
273	R:R:F343	R:R:M339	11.2	No	No	0	4	4
274	R:R:F346	R:R:F350	8.57	No	No	0	6	6
275	R:R:F350	R:R:F353	4.29	No	Yes	0	6	5
276	R:R:F353	R:R:V357	6.55	Yes	No	0	5	5
277	R:R:F354	R:R:F358	15	No	No	0	6	7
278	R:R:F361	R:R:V357	5.24	No	No	0	6	5
279	R:R:F358	R:R:F362	8.57	No	No	0	7	5
280	R:R:E365	R:R:N363	6.57	No	Yes	1	8	9
281	R:R:N363	R:R:V366	8.87	Yes	No	0	9	8
282	R:R:K372	R:R:S368	4.59	No	No	0	6	4
283	R:R:R373	R:R:W377	11	No	No	0	4	4
284	R:R:H375	R:R:W374	7.41	No	No	0	4	4
285	R:R:Q378	R:R:W374	3.29	No	No	0	6	4
286	R:R:H381	R:R:W377	7.41	No	No	0	5	4
287	R:R:Q378	R:R:S382	2.89	No	No	0	6	4
288	R:R:I160	R:R:L131	2.85	No	Yes	0	7	9
289	R:R:I160	R:R:L161	2.85	No	No	0	7	5
290	R:R:E66	R:R:T75	2.82	No	No	0	3	5
291	R:R:E220	R:R:T219	2.82	No	No	0	5	5
292	R:R:K307	R:R:L294	2.82	Yes	No	0	6	6
293	R:R:C360	R:R:F138	2.79	No	No	0	7	7
294	R:R:A140	R:R:R373	2.77	No	No	0	2	4
295	R:R:F353	R:R:S127	2.64	Yes	No	0	5	9
296	R:R:N344	R:R:Q348	2.64	No	No	0	8	8
297	R:R:E82	R:R:N94	2.63	No	No	0	5	7
298	L:L:R29	R:R:V71	2.62	No	No	0	0	4
299	L:L:F37	L:L:V40	2.62	No	No	0	0	0
300	R:R:D45	R:R:Q46	2.61	No	No	0	9	4
301	R:R:R77	R:R:T76	2.59	Yes	No	0	6	4
302	L:L:I36	R:R:F68	2.51	No	No	0	0	6
303	R:R:F200	R:R:I238	2.51	No	No	0	5	7
304	R:R:F327	R:R:I273	2.51	No	No	0	5	4
305	R:R:F327	R:R:L276	2.44	No	No	0	5	7
306	L:L:L20	R:R:R107	2.43	No	No	0	0	1
307	R:R:L247	R:R:Y248	2.34	No	No	0	1	1
308	R:R:Q304	R:R:Y305	2.25	No	No	0	5	5
309	R:R:F326	R:R:F340	2.14	No	No	0	8	7
310	R:R:R77	R:R:Y73	2.06	Yes	Yes	0	6	4
311	R:R:A79	R:R:C98	1.81	No	Yes	0	7	9
312	R:R:G320	R:R:M202	1.75	No	No	0	9	9
313	R:R:A116	R:R:S345	1.71	No	No	0	7	6
314	R:R:G123	R:R:L122	1.71	No	No	0	8	6
315	R:R:C186	R:R:V182	1.71	No	No	0	4	3
316	R:R:G206	R:R:L319	1.71	No	No	0	8	8
317	R:R:G206	R:R:N279	1.7	No	No	0	8	9
318	R:R:G364	R:R:N363	1.7	No	Yes	0	5	9
319	R:R:C50	R:R:T42	1.69	No	No	0	9	4
320	R:R:L102	R:R:P100	1.64	No	No	0	1	1
321	R:R:N78	R:R:P63	1.63	No	No	0	3	4
322	R:R:A241	R:R:I244	1.62	No	No	0	5	4
323	R:R:A90	R:R:K92	1.61	No	No	0	4	7
324	R:R:A296	R:R:K293	1.61	No	No	0	5	7
325	R:R:A311	R:R:K307	1.61	No	Yes	0	8	6
326	R:R:V128	R:R:V132	1.6	No	No	0	6	3
327	R:R:S218	R:R:T211	1.6	No	No	0	5	7
328	R:R:C50	R:R:L44	1.59	No	No	0	9	6
329	R:R:T312	R:R:V287	1.59	No	No	0	7	6
330	R:R:A90	R:R:L84	1.58	No	No	0	4	4
331	R:R:A140	R:R:L136	1.58	No	No	0	2	2
332	R:R:A308	R:R:L294	1.58	No	No	0	7	6
333	L:L:I35	L:L:S39	1.55	No	No	0	0	0
334	R:R:I160	R:R:V164	1.54	No	No	0	7	4
335	R:R:I239	R:R:V240	1.54	No	No	0	7	3
336	R:R:I289	R:R:T292	1.52	No	No	0	7	6
337	R:R:A90	R:R:E82	1.51	No	No	0	4	5
338	L:L:N2	L:L:S4	1.49	No	No	0	0	0
339	L:L:L5	R:R:V328	1.49	Yes	No	0	0	5
340	R:R:L44	R:R:T43	1.47	No	No	0	6	5
341	R:R:I238	R:R:I267	1.47	No	No	0	7	7
342	R:R:D333	R:R:S336	1.47	No	No	0	4	3
343	R:R:D379	R:R:S382	1.47	No	No	0	2	4
344	R:R:I303	R:R:K307	1.45	Yes	Yes	0	5	6
345	L:L:E28	L:L:S25	1.44	No	No	0	0	0
346	R:R:F236	R:R:P237	1.44	No	No	0	4	4
347	R:R:I115	R:R:L111	1.43	No	No	0	4	1
348	R:R:I338	R:R:L335	1.43	No	No	0	3	3
349	R:R:L277	R:R:M324	1.41	No	No	0	3	5
350	R:R:C233	R:R:F229	1.4	No	No	0	7	3
351	R:R:A133	R:R:F361	1.39	No	No	0	4	6
352	R:R:C225	R:R:R223	1.39	No	No	0	3	5
353	L:L:L17	R:R:L117	1.38	No	No	0	0	4
354	R:R:L147	R:R:L222	1.38	Yes	No	0	6	4
355	L:L:L20	R:R:D110	1.36	No	No	0	0	3
356	R:R:D110	R:R:L111	1.36	No	No	0	3	1
357	R:R:L171	R:R:Q170	1.33	No	No	0	2	6
358	R:R:R114	R:R:V118	1.31	No	No	0	2	4
359	R:R:R53	R:R:T42	1.29	No	No	0	3	4
360	R:R:D379	R:R:H380	1.26	No	No	0	2	3
361	R:R:T75	R:R:Y73	1.25	No	Yes	0	5	4
362	R:R:T88	R:R:W89	1.21	No	No	0	5	9
363	R:R:I338	R:R:Y342	1.21	No	No	0	3	6
364	R:R:D379	R:R:R376	1.19	No	No	0	2	5
365	R:R:H375	R:R:R371	1.13	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L5	3.7975	4	0	0
2	L:L:L18	5.1925	4	3	0
3	R:R:W51	6.025	6	4	9
4	R:R:Y73	6.8775	4	8	4
5	R:R:R77	5.8275	4	0	6
6	R:R:I93	5.985	4	4	7
7	R:R:C98	9.665	4	8	9
8	R:R:L131	4.732	5	10	9
9	R:R:L147	4.454	5	1	6
10	R:R:R148	6.724	5	1	8
11	R:R:I151	5.85	5	1	8
12	R:R:H152	5.595	4	1	8
13	R:R:W153	6.1525	4	0	6
14	R:R:W166	10.9425	4	9	7
15	R:R:H174	10.6475	4	3	2
16	R:R:V176	4.8975	4	12	2
17	R:R:H177	10.9175	4	3	2
18	R:R:W183	5.9125	4	12	1
19	R:R:Y193	12.5425	4	1	8
20	R:R:T197	5.6275	4	1	8
21	R:R:N198	10.185	4	0	8
22	R:R:W201	8.045	6	1	9
23	R:R:E205	6.1975	4	1	9
24	R:R:F227	5.93625	8	1	7
25	R:R:P235	7.1975	4	1	9
26	R:R:W242	14.6875	4	2	8
27	R:R:K246	14.3475	4	2	5
28	R:R:W255	9.10571	7	2	9
29	R:R:F256	7.722	5	3	7
30	R:R:L283	4.1125	4	5	7
31	R:R:I303	6.0825	4	0	5
32	R:R:K307	3.985	4	0	6
33	R:R:L316	6.175	4	0	7
34	R:R:T322	7.5125	4	6	8
35	R:R:Y323	6.635	4	6	9
36	R:R:F353	5.102	5	0	5
37	R:R:N363	6.395	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I7	L:L:L5	91.0849	4.28	No	Yes	0	0	0
2	L:L:L5	R:R:Q269	94.4983	3.99	Yes	No	0	0	6
3	R:R:Q269	R:R:Y266	97.8274	15.78	No	No	0	6	6
4	R:R:D265	R:R:Y266	98.9184	3.45	No	No	0	6	6
5	R:R:D265	R:R:Y268	100	6.9	No	No	0	6	8
6	R:R:N192	R:R:Y268	60.3175	15.12	No	No	2	8	8
7	R:R:N192	R:R:V196	63.2439	4.43	No	No	0	8	6
8	R:R:I272	R:R:V196	63.6559	4.61	No	No	0	7	6
9	R:R:F199	R:R:I272	64.082	17.58	No	No	0	8	7
10	R:R:F199	R:R:M202	63.6934	4.98	No	No	0	8	9
11	R:R:M202	R:R:N198	64.6486	5.61	No	Yes	0	9	8
12	R:R:F159	R:R:N198	49.698	10.87	No	Yes	0	9	8
13	R:R:F159	R:R:L131	48.5742	6.09	No	Yes	0	9	9
14	R:R:I160	R:R:L131	28.8851	2.85	No	Yes	0	7	9
15	R:R:I160	R:R:L161	28.7259	2.85	No	No	0	7	5
16	R:R:F194	R:R:L161	53.0318	14.61	No	No	0	6	5
17	R:R:F194	R:R:M165	50.9856	4.98	No	No	11	6	5
18	R:R:F191	R:R:M165	50.2645	8.71	No	No	0	6	5
19	L:L:F11	R:R:F191	38.3528	4.29	No	No	0	0	6
20	L:L:F11	R:R:F256	37.2992	5.36	No	Yes	0	0	7
21	L:L:I7	R:R:Y323	89.9284	3.63	No	Yes	0	0	9
22	R:R:Q348	R:R:Y323	28.253	4.51	No	Yes	0	8	9
23	R:R:N344	R:R:Q348	25.0691	2.64	No	No	0	8	8
24	L:L:L9	R:R:N344	23.463	19.22	No	No	0	0	8
25	L:L:L9	R:R:I341	13.574	8.56	No	No	0	0	6
26	R:R:I341	R:R:Q337	10.3619	8.23	No	No	0	6	4
27	R:R:L131	R:R:S127	31.8912	3	Yes	No	0	9	9
28	R:R:F353	R:R:S127	30.7815	2.64	Yes	No	0	5	9
29	R:R:F350	R:R:F353	23.9266	4.29	No	Yes	0	6	5
30	R:R:F346	R:R:F350	16.7346	8.57	No	No	0	6	6
31	R:R:F346	R:R:V119	15.5031	5.24	No	No	0	6	6
32	R:R:V119	R:R:Y342	14.2623	6.31	No	No	0	6	6
33	R:R:F191	R:R:W166	14.2623	6.01	No	Yes	0	6	7
34	R:R:L161	R:R:T157	29.6249	2.95	No	No	0	5	3
35	R:R:T157	R:R:W153	30.154	6.06	No	Yes	0	3	6
36	R:R:N154	R:R:W153	34.6022	4.52	No	Yes	0	8	6
37	R:R:F227	R:R:N154	20.8035	4.83	Yes	No	1	7	8
38	R:R:F227	R:R:L147	20.8316	4.87	Yes	Yes	1	7	6
39	R:R:L147	R:R:Y208	18.6824	4.69	Yes	No	1	6	7
40	R:R:R148	R:R:Y208	34.93	4.12	Yes	No	1	8	7
41	R:R:N363	R:R:R148	13.972	8.44	Yes	Yes	1	9	8
42	R:R:F227	R:R:I151	71.4567	10.05	Yes	Yes	1	7	8
43	R:R:I151	R:R:Y208	18.7573	4.84	Yes	No	1	8	7
44	R:R:N149	R:R:R148	16.7673	9.64	No	Yes	0	7	8
45	R:R:I144	R:R:N149	11.2141	11.33	No	No	0	7	7
46	R:R:E205	R:R:I151	54.2586	5.47	Yes	Yes	1	9	8
47	R:R:E205	R:R:H152	26.0711	7.39	Yes	Yes	1	9	8
48	R:R:E205	R:R:L318	25.9025	6.63	Yes	No	1	9	8
49	R:R:H152	R:R:Y359	26.1039	4.36	Yes	No	1	8	8
50	R:R:L318	R:R:Y359	24.6289	15.24	No	No	1	8	8
51	R:R:N154	R:R:W201	14.782	15.82	No	Yes	1	8	9
52	R:R:T158	R:R:W201	45.6103	3.64	No	Yes	1	8	9
53	R:R:N198	R:R:T158	50.9482	14.62	Yes	No	0	8	8
54	R:R:T197	R:R:W201	47.9281	3.64	Yes	Yes	1	8	9
55	R:R:C254	R:R:F256	13.6957	5.59	No	Yes	0	9	7
56	R:R:C184	R:R:C254	12.4643	7.28	No	No	0	9	9
57	R:R:T197	R:R:Y193	50.1147	8.74	Yes	Yes	1	8	8
58	R:R:I239	R:R:Y193	52.1187	12.09	No	Yes	0	7	8
59	R:R:I239	R:R:T189	51.2666	4.56	No	No	0	7	6
60	R:R:T189	R:R:W255	50.3957	4.85	No	Yes	0	6	9
61	R:R:T322	R:R:Y323	66.0158	3.75	Yes	Yes	6	8	9
62	R:R:L316	R:R:T322	63.5155	8.84	Yes	Yes	0	7	8
63	R:R:I321	R:R:L316	58.0184	4.28	No	Yes	0	6	7
64	R:R:I321	R:R:L283	47.1789	4.28	No	Yes	5	6	7
65	R:R:L283	R:R:L315	43.611	5.54	Yes	No	5	7	9
66	R:R:L315	R:R:L319	32.3969	8.3	No	No	5	9	8
67	R:R:G206	R:R:L319	31.3995	1.71	No	No	0	8	8
68	R:R:G206	R:R:N279	29.831	1.7	No	No	0	8	9
69	R:R:F282	R:R:N279	23.463	3.62	No	No	0	7	9
70	R:R:F282	R:R:H210	18.5888	16.97	No	No	0	7	8
71	R:R:H210	R:R:V214	15.2924	11.07	No	No	0	8	6
72	R:R:M215	R:R:V214	13.6302	3.04	No	No	0	4	6
73	R:R:M215	R:R:S218	10.2777	12.27	No	No	0	4	5
74	R:R:K246	R:R:W255	44.6645	17.4	Yes	Yes	2	5	9
75	R:R:V314	R:R:Y359	48.0217	3.79	No	No	0	7	8
76	R:R:K310	R:R:V314	37.0043	6.07	No	No	0	7	7
77	R:R:K307	R:R:K310	34.2136	10.06	Yes	No	0	6	7
78	R:R:K307	R:R:L294	17.273	2.82	Yes	No	0	6	6
79	R:R:L294	R:R:Q304	11.5512	15.97	No	No	0	6	5
80	R:R:I303	R:R:K307	11.5512	1.45	Yes	Yes	0	5	6
81	L:L:L18	R:R:F256	12.1834	3.65	Yes	Yes	3	0	7
82	R:R:W242	R:R:Y268	40.7501	26.04	Yes	No	2	8	8
83	R:R:K246	R:R:W242	41.6023	18.57	Yes	Yes	2	5	8
84	R:R:F227	R:R:W201	76.8647	5.01	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N2	R:R:K258	5.6	0	No	No	0	5	0	1
L:L:L5	R:R:Q269	3.99	0	Yes	No	0	6	0	1
L:L:S6	R:R:F340	3.96	0	No	No	0	7	0	1
L:L:I7	R:R:Y323	3.63	0	No	Yes	0	9	0	1
L:L:L9	R:R:I341	8.56	0	No	No	0	6	0	1
L:L:L9	R:R:N344	19.22	0	No	No	0	8	0	1
L:L:T10	R:R:Q348	5.67	0	No	No	0	8	0	1
L:L:F11	R:R:F191	4.29	0	No	No	0	6	0	1
L:L:F11	R:R:F256	5.36	0	No	Yes	0	7	0	1
L:L:H12	R:R:I341	5.3	0	No	No	0	6	0	1
L:L:L13	R:R:Y113	15.24	7	No	No	0	4	0	1
L:L:L14	R:R:F256	3.65	0	No	Yes	0	7	0	1
L:L:R15	R:R:G257	3	0	No	No	0	5	0	1
L:L:R15	R:R:K258	6.19	0	No	No	0	5	0	1
L:L:T16	R:R:Y113	3.75	7	No	No	0	4	0	1
L:L:L17	R:R:Y113	14.07	0	No	No	0	4	0	1
L:L:L18	R:R:V172	2.98	3	Yes	No	0	4	0	1
L:L:L18	R:R:H174	5.14	3	Yes	Yes	0	2	0	1
L:L:L18	R:R:H177	9	3	Yes	Yes	0	2	0	1
L:L:L18	R:R:F256	3.65	3	Yes	Yes	0	7	0	1
L:L:E19	R:R:H174	7.39	0	No	Yes	0	2	0	1
L:L:R22	R:R:H174	21.44	3	No	Yes	0	2	0	1
L:L:R22	R:R:E178	8.14	3	No	No	0	3	0	1
L:L:T23	R:R:R107	3.88	0	No	No	0	1	0	1
L:L:R29	R:R:N69	10.85	0	No	No	0	3	0	1
L:L:A30	R:R:P100	3.74	0	No	No	0	1	0	1
L:L:N33	R:R:F68	7.25	0	No	No	0	6	0	1
L:L:N33	R:R:Y95	6.98	0	No	No	0	5	0	1
L:L:N33	R:R:P100	3.26	0	No	No	0	1	0	1
L:L:F37	R:R:I93	3.77	0	No	Yes	0	7	0	1
L:L:F37	R:R:Y95	27.85	0	No	No	0	5	0	1
R:R:D45	R:R:W51	6.7	4	No	Yes	9	9	2	2
R:R:D45	R:R:I93	4.2	4	No	Yes	9	7	2	1
R:R:R81	R:R:W51	7	4	No	Yes	8	9	2	2
R:R:I93	R:R:W51	4.7	4	Yes	Yes	7	9	1	2
R:R:F68	R:R:N69	14.5	0	No	No	6	3	1	1
R:R:I93	R:R:R81	11.27	4	Yes	No	7	8	1	2
R:R:C98	R:R:Y95	20.16	8	Yes	No	9	5	2	1
R:R:F191	R:R:M165	8.71	0	No	No	6	5	1	2
R:R:F191	R:R:W166	6.01	0	No	Yes	6	7	1	2
R:R:V172	R:R:V176	3.21	0	No	Yes	4	2	1	2
R:R:E178	R:R:H174	8.62	3	No	Yes	3	2	1	1
R:R:H177	R:R:Q253	11.13	3	Yes	No	2	4	1	2
R:R:F256	R:R:H177	20.36	3	Yes	Yes	7	2	1	1
R:R:G257	R:R:H177	3.18	3	No	Yes	5	2	1	1
R:R:G257	R:R:Q253	4.93	3	No	No	5	4	1	2
R:R:C254	R:R:F256	5.59	0	No	Yes	9	7	2	1
R:R:Q269	R:R:Y266	15.78	0	No	No	6	6	1	2
R:R:G270	R:R:Q269	4.93	0	No	No	5	6	2	1
R:R:T322	R:R:Y323	3.75	6	Yes	Yes	8	9	2	1
R:R:Q351	R:R:T322	5.67	6	No	Yes	9	8	2	2
R:R:Q348	R:R:Y323	4.51	0	No	Yes	8	9	1	1
R:R:Q351	R:R:Y323	14.65	6	No	Yes	9	9	2	1
R:R:F340	R:R:Q337	8.2	0	No	No	7	4	1	2
R:R:I341	R:R:Q337	8.23	0	No	No	6	4	1	2
R:R:N344	R:R:Q348	2.64	0	No	No	8	8	1	1
L:L:R29	R:R:V71	2.62	0	No	No	0	4	0	1
L:L:I36	R:R:F68	2.51	0	No	No	0	6	0	1
L:L:L20	R:R:R107	2.43	0	No	No	0	1	0	1
R:R:F326	R:R:F340	2.14	0	No	No	8	7	2	1
R:R:L102	R:R:P100	1.64	0	No	No	1	1	2	1
L:L:L5	R:R:V328	1.49	0	Yes	No	0	5	0	1
L:L:L17	R:R:L117	1.38	0	No	No	0	4	0	1
L:L:L20	R:R:D110	1.36	0	No	No	0	3	0	1
R:R:D110	R:R:L111	1.36	0	No	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TRY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	337
Number of Links	365
Number of Hubs	37
Number of Links mediated by Hubs	140
Number of Communities	12
Number of Nodes involved in Communities	72
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	46675
Length Of Smallest Path	3
Average Path Length	18.9191
Length of Longest Path	44
Minimum Path Strength	1.225
Average Path Strength	7.16607
Maximum Path Strength	24.005
Minimum Path Correlation	0.7
Average Path Correlation	0.970365
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	63.7406
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.7439
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Urocortin
UniProt	P55089
Sequence	>7TRY_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q13324
Sequence	>7TRY_nogp_Chain_R N T T L D Q I G T C W P R E R P C P E Y F N G V K Y N T T R N A Y R E C L T W A S K I N Y S Q C E P I L Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L R S I R C L R N V I H W N L I T T F I L R N V M W F L L Q L V D H E V H E S N E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M T Y S T E R L R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E N E Q C W F G K E P L V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E D D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R S A V R K R W H R W Q D H H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6PB1	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	2.8	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	6PB1 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	7TRY	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-G11)/β1/γ2	3.7	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TRY (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		3.7	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TS0	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1L-Go)/β1/γ2	2.8	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TS0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2022-11-09	doi.org/10.1038/s41467-022-33851-3

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