psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N2	L:L:P3	3.26	No	No	0	0	0
2	L:L:N2	R:R:K258	5.6	No	No	0	0	5
3	L:L:I7	L:L:L5	4.28	No	Yes	0	0	0
4	L:L:D8	L:L:L5	5.43	No	Yes	0	0	0
5	L:L:L5	R:R:Q269	3.99	Yes	No	0	0	6
6	L:L:S6	R:R:F340	3.96	No	No	0	0	7
7	L:L:I7	R:R:Y323	3.63	No	Yes	0	0	9
8	L:L:L13	L:L:L9	4.15	No	No	0	0	0
9	L:L:L9	R:R:I341	8.56	No	No	0	0	6
10	L:L:L9	R:R:N344	19.22	No	No	0	0	8
11	L:L:T10	R:R:Q348	5.67	No	No	0	0	8
12	L:L:F11	R:R:F191	4.29	No	No	0	0	6
13	L:L:F11	R:R:F256	5.36	No	Yes	0	0	7
14	L:L:H12	L:L:T16	6.85	No	No	0	0	0
15	L:L:H12	R:R:I341	5.3	No	No	0	0	6
16	L:L:L13	L:L:T16	2.95	No	No	7	0	0
17	L:L:L13	R:R:Y113	15.24	No	No	7	0	4
18	L:L:L14	R:R:F256	3.65	No	Yes	0	0	7
19	L:L:R15	R:R:G257	3	No	No	0	0	5
20	L:L:R15	R:R:K258	6.19	No	No	0	0	5
21	L:L:T16	R:R:Y113	3.75	No	No	7	0	4
22	L:L:L17	R:R:Y113	14.07	No	No	0	0	4
23	L:L:L18	R:R:V172	2.98	Yes	No	0	0	4
24	L:L:L18	R:R:H174	5.14	Yes	Yes	3	0	2
25	L:L:L18	R:R:H177	9	Yes	Yes	3	0	2
26	L:L:L18	R:R:F256	3.65	Yes	Yes	3	0	7
27	L:L:E19	R:R:H174	7.39	No	Yes	0	0	2
28	L:L:Q26	L:L:R22	17.52	No	No	0	0	0
29	L:L:R22	R:R:H174	21.44	No	Yes	3	0	2
30	L:L:R22	R:R:E178	8.14	No	No	3	0	3
31	L:L:T23	R:R:R107	3.88	No	No	0	0	1
32	L:L:Q24	L:L:R27	8.18	No	No	0	0	0
33	L:L:E31	L:L:R27	4.65	No	No	0	0	0
34	L:L:E28	L:L:R29	5.82	No	No	0	0	0
35	L:L:R29	R:R:N69	10.85	No	No	0	0	3
36	L:L:A30	R:R:P100	3.74	No	No	0	0	1
37	L:L:I35	L:L:Q32	5.49	No	No	0	0	0
38	L:L:I36	L:L:Q32	4.12	No	No	0	0	0
39	L:L:N33	R:R:F68	7.25	No	No	0	0	6
40	L:L:N33	R:R:Y95	6.98	No	No	0	0	5
41	L:L:N33	R:R:P100	3.26	No	No	0	0	1
42	L:L:D38	L:L:R34	10.72	No	No	0	0	0
43	L:L:F37	R:R:I93	3.77	No	Yes	0	0	7
44	L:L:F37	R:R:Y95	27.85	No	No	0	0	5
45	L:L:D38	L:L:S39	4.42	No	No	0	0	0
46	R:R:T43	R:R:W89	8.49	No	No	0	5	9
47	R:R:G48	R:R:L44	3.42	No	No	0	7	6
48	R:R:D45	R:R:W51	6.7	No	Yes	4	9	9
49	R:R:D45	R:R:I93	4.2	No	Yes	4	9	7
50	R:R:G48	R:R:I47	3.53	No	No	0	7	6
51	R:R:I47	R:R:T49	6.08	No	No	0	6	4
52	R:R:I47	R:R:P65	3.39	No	No	0	6	8
53	R:R:T49	R:R:W51	9.7	No	Yes	4	4	9
54	R:R:R62	R:R:T49	5.17	No	No	4	4	4
55	R:R:P52	R:R:W51	4.05	No	Yes	0	5	9
56	R:R:R62	R:R:W51	4	No	Yes	4	4	9
57	R:R:R81	R:R:W51	7	No	Yes	4	8	9
58	R:R:I93	R:R:W51	4.7	Yes	Yes	4	7	9
59	R:R:E61	R:R:Y80	17.96	No	No	0	5	4
60	R:R:P63	R:R:R62	8.65	No	No	0	4	4
61	R:R:C64	R:R:Y73	14.79	No	Yes	8	9	4
62	R:R:C64	R:R:C98	7.28	No	Yes	8	9	9
63	R:R:E66	R:R:Y67	4.49	No	No	0	3	5
64	R:R:F68	R:R:N69	14.5	No	No	0	6	3
65	R:R:I101	R:R:K72	5.82	No	No	0	2	1
66	R:R:C98	R:R:Y73	9.41	Yes	Yes	8	9	4
67	R:R:N74	R:R:T76	14.62	No	No	0	5	4
68	R:R:Q97	R:R:R77	11.68	No	Yes	0	7	6
69	R:R:E99	R:R:R77	6.98	No	Yes	0	1	6
70	R:R:E82	R:R:Y80	3.37	No	No	0	5	4
71	R:R:I93	R:R:R81	11.27	Yes	No	4	7	8
72	R:R:L84	R:R:T88	2.95	No	No	0	4	5
73	R:R:N94	R:R:S96	7.45	No	No	0	7	6
74	R:R:C98	R:R:Y95	20.16	Yes	No	0	9	5
75	R:R:H112	R:R:Y109	5.44	No	No	0	4	3
76	R:R:H112	R:R:I338	17.23	No	No	0	4	3
77	R:R:I115	R:R:Y342	3.63	No	No	0	4	6
78	R:R:L122	R:R:V118	4.47	No	No	0	6	4
79	R:R:V119	R:R:Y342	6.31	No	No	0	6	6
80	R:R:F346	R:R:V119	5.24	No	No	0	6	6
81	R:R:N120	R:R:S345	5.96	No	No	0	7	6
82	R:R:N120	R:R:S349	5.96	No	No	0	7	9
83	R:R:L122	R:R:Y121	4.69	No	No	0	6	5
84	R:R:F350	R:R:G123	4.52	No	No	0	6	8
85	R:R:H124	R:R:N163	3.83	No	No	9	6	7
86	R:R:H124	R:R:W166	20.1	No	Yes	9	6	7
87	R:R:H124	R:R:S349	8.37	No	No	0	6	9
88	R:R:F353	R:R:V126	7.87	Yes	No	0	5	5
89	R:R:L131	R:R:S127	3	Yes	No	0	9	9
90	R:R:N163	R:R:V128	5.91	No	No	0	7	6
91	R:R:A130	R:R:F353	4.16	No	Yes	0	6	5
92	R:R:I156	R:R:L131	5.71	No	Yes	10	7	9
93	R:R:F159	R:R:L131	6.09	No	Yes	0	9	9
94	R:R:L131	R:R:S356	6.01	Yes	No	10	9	8
95	R:R:A134	R:R:C360	3.61	No	No	0	8	7
96	R:R:F135	R:R:W153	6.01	No	Yes	0	5	6
97	R:R:L137	R:R:V366	2.98	No	No	0	8	8
98	R:R:L137	R:R:V370	5.96	No	No	0	8	4
99	R:R:F138	R:R:W153	8.02	No	Yes	0	7	6
100	R:R:L141	R:R:S143	9.01	No	No	0	6	5
101	R:R:I144	R:R:L141	5.71	No	No	0	7	6
102	R:R:A369	R:R:L141	6.3	No	No	0	7	6
103	R:R:I144	R:R:N149	11.33	No	No	0	7	7
104	R:R:C146	R:R:N149	7.87	No	No	0	7	7
105	R:R:I151	R:R:L147	4.28	Yes	Yes	1	8	6
106	R:R:L147	R:R:Y208	4.69	Yes	No	1	6	7
107	R:R:K224	R:R:L147	7.05	No	Yes	1	5	6
108	R:R:F227	R:R:L147	4.87	Yes	Yes	1	7	6
109	R:R:N149	R:R:R148	9.64	No	Yes	0	7	8
110	R:R:H152	R:R:R148	6.77	Yes	Yes	1	8	8
111	R:R:R148	R:R:Y208	4.12	Yes	No	1	8	7
112	R:R:N363	R:R:R148	8.44	Yes	Yes	1	9	8
113	R:R:E365	R:R:R148	4.65	No	Yes	1	8	8
114	R:R:K224	R:R:V150	4.55	No	No	1	5	5
115	R:R:F227	R:R:V150	5.24	Yes	No	1	7	5
116	R:R:I151	R:R:V204	4.61	Yes	No	1	8	7
117	R:R:E205	R:R:I151	5.47	Yes	Yes	1	9	8
118	R:R:I151	R:R:Y208	4.84	Yes	No	1	8	7
119	R:R:F227	R:R:I151	10.05	Yes	Yes	1	7	8
120	R:R:E205	R:R:H152	7.39	Yes	Yes	1	9	8
121	R:R:H152	R:R:L318	3.86	Yes	No	1	8	8
122	R:R:H152	R:R:Y359	4.36	Yes	No	1	8	8
123	R:R:N154	R:R:W153	4.52	No	Yes	0	8	6
124	R:R:T157	R:R:W153	6.06	No	Yes	0	3	6
125	R:R:N154	R:R:W201	15.82	No	Yes	1	8	9
126	R:R:F227	R:R:N154	4.83	Yes	No	1	7	8
127	R:R:E205	R:R:L155	5.3	Yes	No	0	9	8
128	R:R:I156	R:R:S356	3.1	No	No	10	7	8
129	R:R:L161	R:R:T157	2.95	No	No	0	5	3
130	R:R:T158	R:R:T197	3.14	No	Yes	1	8	8
131	R:R:N198	R:R:T158	14.62	Yes	No	0	8	8
132	R:R:T158	R:R:W201	3.64	No	Yes	1	8	9
133	R:R:F159	R:R:N198	10.87	No	Yes	0	9	8
134	R:R:F159	R:R:G352	4.52	No	No	0	9	9
135	R:R:F194	R:R:L161	14.61	No	No	0	6	5
136	R:R:R162	R:R:V195	6.54	No	No	0	8	6
137	R:R:N198	R:R:R162	9.64	Yes	No	0	8	8
138	R:R:N163	R:R:W166	4.52	No	Yes	9	7	7
139	R:R:I190	R:R:M165	5.83	No	No	11	4	5
140	R:R:F191	R:R:M165	8.71	No	No	0	6	5
141	R:R:F194	R:R:M165	4.98	No	No	11	6	5
142	R:R:Q170	R:R:W166	13.14	No	Yes	0	6	7
143	R:R:F191	R:R:W166	6.01	No	Yes	0	6	7
144	R:R:I187	R:R:L168	7.14	No	No	0	6	4
145	R:R:I187	R:R:L169	5.71	No	No	0	6	6
146	R:R:V172	R:R:V176	3.21	No	Yes	0	4	2
147	R:R:D173	R:R:E175	9.09	No	No	0	3	1
148	R:R:D173	R:R:V176	4.38	No	Yes	0	3	2
149	R:R:E178	R:R:H174	8.62	No	Yes	3	3	2
150	R:R:V176	R:R:W183	8.58	Yes	Yes	12	2	1
151	R:R:C184	R:R:V176	3.42	No	Yes	12	9	2
152	R:R:H177	R:R:Q253	11.13	Yes	No	3	2	4
153	R:R:F256	R:R:H177	20.36	Yes	Yes	3	7	2
154	R:R:G257	R:R:H177	3.18	No	Yes	3	5	2
155	R:R:E181	R:R:S179	7.19	No	No	0	3	1
156	R:R:N180	R:R:R185	6.03	No	No	2	5	6
157	R:R:N180	R:R:N251	8.17	No	No	2	5	5
158	R:R:N180	R:R:W255	6.78	No	Yes	2	5	9
159	R:R:E181	R:R:W183	7.63	No	Yes	0	3	1
160	R:R:R185	R:R:V182	13.08	No	No	0	6	3
161	R:R:C184	R:R:W183	3.92	No	Yes	12	9	1
162	R:R:I187	R:R:W183	3.52	No	Yes	0	6	1
163	R:R:C184	R:R:C254	7.28	No	No	0	9	9
164	R:R:R185	R:R:W255	21.99	No	Yes	2	6	9
165	R:R:T188	R:R:W255	3.64	No	Yes	0	7	9
166	R:R:I239	R:R:T189	4.56	No	No	0	7	6
167	R:R:A243	R:R:T189	3.36	No	No	0	4	6
168	R:R:T189	R:R:W255	4.85	No	Yes	0	6	9
169	R:R:F194	R:R:I190	6.28	No	No	11	6	4
170	R:R:N192	R:R:V196	4.43	No	No	0	8	6
171	R:R:N192	R:R:W242	6.78	No	Yes	2	8	8
172	R:R:N192	R:R:Y268	15.12	No	No	2	8	8
173	R:R:T197	R:R:Y193	8.74	Yes	Yes	1	8	8
174	R:R:P235	R:R:Y193	9.74	Yes	Yes	1	9	8
175	R:R:F236	R:R:Y193	19.6	No	Yes	0	4	8
176	R:R:I239	R:R:Y193	12.09	No	Yes	0	7	8
177	R:R:F199	R:R:V195	5.24	No	No	0	8	6
178	R:R:I272	R:R:V196	4.61	No	No	0	7	6
179	R:R:T197	R:R:W201	3.64	Yes	Yes	1	8	9
180	R:R:P235	R:R:T197	6.99	Yes	Yes	1	9	8
181	R:R:M202	R:R:N198	5.61	No	Yes	0	9	8
182	R:R:F199	R:R:M202	4.98	No	No	0	8	9
183	R:R:F199	R:R:I272	17.58	No	No	0	8	7
184	R:R:F200	R:R:I234	6.28	No	No	1	5	3
185	R:R:F200	R:R:P235	8.67	No	Yes	1	5	9
186	R:R:F227	R:R:W201	5.01	Yes	Yes	1	7	9
187	R:R:G231	R:R:W201	9.85	No	Yes	0	8	9
188	R:R:W201	R:R:W232	10.31	Yes	No	0	9	9
189	R:R:C207	R:R:F203	8.38	No	No	0	5	7
190	R:R:F203	R:R:V275	9.18	No	No	0	7	7
191	R:R:F227	R:R:V204	3.93	Yes	No	1	7	7
192	R:R:I230	R:R:V204	3.07	No	No	0	4	7
193	R:R:E205	R:R:L318	6.63	Yes	No	1	9	8
194	R:R:I286	R:R:L209	4.28	No	No	0	8	8
195	R:R:L209	R:R:L315	4.15	No	No	5	8	9
196	R:R:L209	R:R:L319	4.15	No	No	5	8	8
197	R:R:H210	R:R:V214	11.07	No	No	0	8	6
198	R:R:F282	R:R:H210	16.97	No	No	0	7	8
199	R:R:H210	R:R:N285	12.75	No	No	0	8	6
200	R:R:T211	R:R:T219	3.14	No	No	0	7	5
201	R:R:A212	R:R:T219	3.36	No	No	0	7	5
202	R:R:I213	R:R:I286	7.36	No	No	0	7	8
203	R:R:I213	R:R:I289	5.89	No	No	0	7	7
204	R:R:M215	R:R:V214	3.04	No	No	0	4	6
205	R:R:M215	R:R:Y217	4.79	No	No	0	4	7
206	R:R:M215	R:R:S218	12.27	No	No	0	4	5
207	R:R:R221	R:R:S218	6.59	No	No	0	4	5
208	R:R:F227	R:R:K224	8.69	Yes	No	1	7	5
209	R:R:F227	R:R:L228	4.87	Yes	No	0	7	5
210	R:R:L228	R:R:W232	5.69	No	No	0	5	9
211	R:R:G231	R:R:I230	3.53	No	No	0	8	4
212	R:R:I230	R:R:I234	4.42	No	No	0	4	3
213	R:R:I234	R:R:P235	3.39	No	Yes	1	3	9
214	R:R:K246	R:R:W242	18.57	Yes	Yes	2	5	8
215	R:R:V264	R:R:W242	7.36	No	Yes	2	4	8
216	R:R:W242	R:R:Y268	26.04	Yes	No	2	8	8
217	R:R:G245	R:R:I244	5.29	No	No	0	4	4
218	R:R:I244	R:R:Y248	15.71	No	No	0	4	1
219	R:R:E250	R:R:K246	10.8	No	Yes	0	6	5
220	R:R:K246	R:R:W255	17.4	Yes	Yes	2	5	9
221	R:R:K246	R:R:V264	10.62	Yes	No	2	5	4
222	R:R:L247	R:R:W255	5.69	No	Yes	0	1	9
223	R:R:V264	R:R:Y249	3.79	No	No	0	4	4
224	R:R:E250	R:R:E259	20.3	No	No	0	6	3
225	R:R:N251	R:R:W255	3.39	No	Yes	2	5	9
226	R:R:G257	R:R:Q253	4.93	No	No	3	5	4
227	R:R:C254	R:R:F256	5.59	No	Yes	0	9	7
228	R:R:E259	R:R:P260	3.14	No	No	0	3	5
229	R:R:D265	R:R:Y266	3.45	No	No	0	6	6
230	R:R:D265	R:R:Y268	6.9	No	No	0	6	8
231	R:R:Q269	R:R:Y266	15.78	No	No	0	6	6
232	R:R:G270	R:R:Q269	4.93	No	No	0	5	6
233	R:R:G270	R:R:P271	4.06	No	No	0	5	9
234	R:R:N279	R:R:V275	2.96	No	No	0	9	7
235	R:R:I278	R:R:V281	3.07	No	No	0	5	3
236	R:R:F282	R:R:I278	7.54	No	No	0	7	5
237	R:R:F282	R:R:N279	3.62	No	No	0	7	9
238	R:R:F280	R:R:L283	3.65	No	Yes	5	5	7
239	R:R:F280	R:R:I321	12.56	No	No	5	5	6
240	R:R:F280	R:R:M324	4.98	No	No	0	5	5
241	R:R:L283	R:R:V287	2.98	Yes	No	0	7	6
242	R:R:L283	R:R:L315	5.54	Yes	No	5	7	9
243	R:R:I321	R:R:L283	4.28	No	Yes	5	6	7
244	R:R:I286	R:R:L290	4.28	No	No	0	8	7
245	R:R:M291	R:R:Q304	5.44	No	No	0	4	5
246	R:R:K293	R:R:S297	7.65	No	No	0	7	4
247	R:R:L294	R:R:Q304	15.97	No	No	0	6	5
248	R:R:I303	R:R:T298	15.2	Yes	No	0	5	5
249	R:R:I303	R:R:S300	4.64	Yes	No	0	5	6
250	R:R:E301	R:R:Y305	15.71	No	No	0	5	5
251	R:R:I303	R:R:T302	3.04	Yes	No	0	5	5
252	R:R:K307	R:R:K310	10.06	Yes	No	0	6	7
253	R:R:L313	R:R:V309	2.98	No	No	0	6	6
254	R:R:K310	R:R:V314	6.07	No	No	0	7	7
255	R:R:F358	R:R:V314	7.87	No	No	0	7	7
256	R:R:V314	R:R:Y359	3.79	No	No	0	7	8
257	R:R:L315	R:R:L319	8.3	No	No	5	9	8
258	R:R:L316	R:R:P317	3.28	Yes	No	0	7	7
259	R:R:I321	R:R:L316	4.28	No	Yes	0	6	7
260	R:R:L316	R:R:T322	8.84	Yes	Yes	0	7	8
261	R:R:L316	R:R:L325	8.3	Yes	No	0	7	6
262	R:R:P317	R:R:V355	3.53	No	No	0	7	9
263	R:R:L318	R:R:Y359	15.24	No	No	1	8	8
264	R:R:T322	R:R:Y323	3.75	Yes	Yes	6	8	9
265	R:R:L347	R:R:T322	11.79	No	Yes	0	5	8
266	R:R:Q351	R:R:T322	5.67	No	Yes	6	9	8
267	R:R:Q348	R:R:Y323	4.51	No	Yes	0	8	9
268	R:R:Q351	R:R:Y323	14.65	No	Yes	6	9	9
269	R:R:F327	R:R:M324	9.95	No	No	0	5	5
270	R:R:F326	R:R:F343	9.65	No	No	0	8	4
271	R:R:F340	R:R:Q337	8.2	No	No	0	7	4
272	R:R:I341	R:R:Q337	8.23	No	No	0	6	4
273	R:R:F343	R:R:M339	11.2	No	No	0	4	4
274	R:R:F346	R:R:F350	8.57	No	No	0	6	6
275	R:R:F350	R:R:F353	4.29	No	Yes	0	6	5
276	R:R:F353	R:R:V357	6.55	Yes	No	0	5	5
277	R:R:F354	R:R:F358	15	No	No	0	6	7
278	R:R:F361	R:R:V357	5.24	No	No	0	6	5
279	R:R:F358	R:R:F362	8.57	No	No	0	7	5
280	R:R:E365	R:R:N363	6.57	No	Yes	1	8	9
281	R:R:N363	R:R:V366	8.87	Yes	No	0	9	8
282	R:R:K372	R:R:S368	4.59	No	No	0	6	4
283	R:R:R373	R:R:W377	11	No	No	0	4	4
284	R:R:H375	R:R:W374	7.41	No	No	0	4	4
285	R:R:Q378	R:R:W374	3.29	No	No	0	6	4
286	R:R:H381	R:R:W377	7.41	No	No	0	5	4
287	R:R:Q378	R:R:S382	2.89	No	No	0	6	4
288	R:R:I160	R:R:L131	2.85	No	Yes	0	7	9
289	R:R:I160	R:R:L161	2.85	No	No	0	7	5
290	R:R:E66	R:R:T75	2.82	No	No	0	3	5
291	R:R:E220	R:R:T219	2.82	No	No	0	5	5
292	R:R:K307	R:R:L294	2.82	Yes	No	0	6	6
293	R:R:C360	R:R:F138	2.79	No	No	0	7	7
294	R:R:A140	R:R:R373	2.77	No	No	0	2	4
295	R:R:F353	R:R:S127	2.64	Yes	No	0	5	9
296	R:R:N344	R:R:Q348	2.64	No	No	0	8	8
297	R:R:E82	R:R:N94	2.63	No	No	0	5	7
298	L:L:R29	R:R:V71	2.62	No	No	0	0	4
299	L:L:F37	L:L:V40	2.62	No	No	0	0	0
300	R:R:D45	R:R:Q46	2.61	No	No	0	9	4
301	R:R:R77	R:R:T76	2.59	Yes	No	0	6	4
302	L:L:I36	R:R:F68	2.51	No	No	0	0	6
303	R:R:F200	R:R:I238	2.51	No	No	0	5	7
304	R:R:F327	R:R:I273	2.51	No	No	0	5	4
305	R:R:F327	R:R:L276	2.44	No	No	0	5	7
306	L:L:L20	R:R:R107	2.43	No	No	0	0	1
307	R:R:L247	R:R:Y248	2.34	No	No	0	1	1
308	R:R:Q304	R:R:Y305	2.25	No	No	0	5	5
309	R:R:F326	R:R:F340	2.14	No	No	0	8	7
310	R:R:R77	R:R:Y73	2.06	Yes	Yes	0	6	4
311	R:R:A79	R:R:C98	1.81	No	Yes	0	7	9
312	R:R:G320	R:R:M202	1.75	No	No	0	9	9
313	R:R:A116	R:R:S345	1.71	No	No	0	7	6
314	R:R:G123	R:R:L122	1.71	No	No	0	8	6
315	R:R:C186	R:R:V182	1.71	No	No	0	4	3
316	R:R:G206	R:R:L319	1.71	No	No	0	8	8
317	R:R:G206	R:R:N279	1.7	No	No	0	8	9
318	R:R:G364	R:R:N363	1.7	No	Yes	0	5	9
319	R:R:C50	R:R:T42	1.69	No	No	0	9	4
320	R:R:L102	R:R:P100	1.64	No	No	0	1	1
321	R:R:N78	R:R:P63	1.63	No	No	0	3	4
322	R:R:A241	R:R:I244	1.62	No	No	0	5	4
323	R:R:A90	R:R:K92	1.61	No	No	0	4	7
324	R:R:A296	R:R:K293	1.61	No	No	0	5	7
325	R:R:A311	R:R:K307	1.61	No	Yes	0	8	6
326	R:R:V128	R:R:V132	1.6	No	No	0	6	3
327	R:R:S218	R:R:T211	1.6	No	No	0	5	7
328	R:R:C50	R:R:L44	1.59	No	No	0	9	6
329	R:R:T312	R:R:V287	1.59	No	No	0	7	6
330	R:R:A90	R:R:L84	1.58	No	No	0	4	4
331	R:R:A140	R:R:L136	1.58	No	No	0	2	2
332	R:R:A308	R:R:L294	1.58	No	No	0	7	6
333	L:L:I35	L:L:S39	1.55	No	No	0	0	0
334	R:R:I160	R:R:V164	1.54	No	No	0	7	4
335	R:R:I239	R:R:V240	1.54	No	No	0	7	3
336	R:R:I289	R:R:T292	1.52	No	No	0	7	6
337	R:R:A90	R:R:E82	1.51	No	No	0	4	5
338	L:L:N2	L:L:S4	1.49	No	No	0	0	0
339	L:L:L5	R:R:V328	1.49	Yes	No	0	0	5
340	R:R:L44	R:R:T43	1.47	No	No	0	6	5
341	R:R:I238	R:R:I267	1.47	No	No	0	7	7
342	R:R:D333	R:R:S336	1.47	No	No	0	4	3
343	R:R:D379	R:R:S382	1.47	No	No	0	2	4
344	R:R:I303	R:R:K307	1.45	Yes	Yes	0	5	6
345	L:L:E28	L:L:S25	1.44	No	No	0	0	0
346	R:R:F236	R:R:P237	1.44	No	No	0	4	4
347	R:R:I115	R:R:L111	1.43	No	No	0	4	1
348	R:R:I338	R:R:L335	1.43	No	No	0	3	3
349	R:R:L277	R:R:M324	1.41	No	No	0	3	5
350	R:R:C233	R:R:F229	1.4	No	No	0	7	3
351	R:R:A133	R:R:F361	1.39	No	No	0	4	6
352	R:R:C225	R:R:R223	1.39	No	No	0	3	5
353	L:L:L17	R:R:L117	1.38	No	No	0	0	4
354	R:R:L147	R:R:L222	1.38	Yes	No	0	6	4
355	L:L:L20	R:R:D110	1.36	No	No	0	0	3
356	R:R:D110	R:R:L111	1.36	No	No	0	3	1
357	R:R:L171	R:R:Q170	1.33	No	No	0	2	6
358	R:R:R114	R:R:V118	1.31	No	No	0	2	4
359	R:R:R53	R:R:T42	1.29	No	No	0	3	4
360	R:R:D379	R:R:H380	1.26	No	No	0	2	3
361	R:R:T75	R:R:Y73	1.25	No	Yes	0	5	4
362	R:R:T88	R:R:W89	1.21	No	No	0	5	9
363	R:R:I338	R:R:Y342	1.21	No	No	0	3	6
364	R:R:D379	R:R:R376	1.19	No	No	0	2	5
365	R:R:H375	R:R:R371	1.13	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L5	3.7975	4	0	0
2	L:L:L18	5.1925	4	3	0
3	R:R:W51	6.025	6	4	9
4	R:R:Y73	6.8775	4	8	4
5	R:R:R77	5.8275	4	0	6
6	R:R:I93	5.985	4	4	7
7	R:R:C98	9.665	4	8	9
8	R:R:L131	4.732	5	10	9
9	R:R:L147	4.454	5	1	6
10	R:R:R148	6.724	5	1	8
11	R:R:I151	5.85	5	1	8
12	R:R:H152	5.595	4	1	8
13	R:R:W153	6.1525	4	0	6
14	R:R:W166	10.9425	4	9	7
15	R:R:H174	10.6475	4	3	2
16	R:R:V176	4.8975	4	12	2
17	R:R:H177	10.9175	4	3	2
18	R:R:W183	5.9125	4	12	1
19	R:R:Y193	12.5425	4	1	8
20	R:R:T197	5.6275	4	1	8
21	R:R:N198	10.185	4	0	8
22	R:R:W201	8.045	6	1	9
23	R:R:E205	6.1975	4	1	9
24	R:R:F227	5.93625	8	1	7
25	R:R:P235	7.1975	4	1	9
26	R:R:W242	14.6875	4	2	8
27	R:R:K246	14.3475	4	2	5
28	R:R:W255	9.10571	7	2	9
29	R:R:F256	7.722	5	3	7
30	R:R:L283	4.1125	4	5	7
31	R:R:I303	6.0825	4	0	5
32	R:R:K307	3.985	4	0	6
33	R:R:L316	6.175	4	0	7
34	R:R:T322	7.5125	4	6	8
35	R:R:Y323	6.635	4	6	9
36	R:R:F353	5.102	5	0	5
37	R:R:N363	6.395	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I7	L:L:L5	91.0849	4.28	No	Yes	0	0	0
2	L:L:L5	R:R:Q269	94.4983	3.99	Yes	No	0	0	6
3	R:R:Q269	R:R:Y266	97.8274	15.78	No	No	0	6	6
4	R:R:D265	R:R:Y266	98.9184	3.45	No	No	0	6	6
5	R:R:D265	R:R:Y268	100	6.9	No	No	0	6	8
6	R:R:N192	R:R:Y268	60.3175	15.12	No	No	2	8	8
7	R:R:N192	R:R:V196	63.2439	4.43	No	No	0	8	6
8	R:R:I272	R:R:V196	63.6559	4.61	No	No	0	7	6
9	R:R:F199	R:R:I272	64.082	17.58	No	No	0	8	7
10	R:R:F199	R:R:M202	63.6934	4.98	No	No	0	8	9
11	R:R:M202	R:R:N198	64.6486	5.61	No	Yes	0	9	8
12	R:R:F159	R:R:N198	49.698	10.87	No	Yes	0	9	8
13	R:R:F159	R:R:L131	48.5742	6.09	No	Yes	0	9	9
14	R:R:I160	R:R:L131	28.8851	2.85	No	Yes	0	7	9
15	R:R:I160	R:R:L161	28.7259	2.85	No	No	0	7	5
16	R:R:F194	R:R:L161	53.0318	14.61	No	No	0	6	5
17	R:R:F194	R:R:M165	50.9856	4.98	No	No	11	6	5
18	R:R:F191	R:R:M165	50.2645	8.71	No	No	0	6	5
19	L:L:F11	R:R:F191	38.3528	4.29	No	No	0	0	6
20	L:L:F11	R:R:F256	37.2992	5.36	No	Yes	0	0	7
21	L:L:I7	R:R:Y323	89.9284	3.63	No	Yes	0	0	9
22	R:R:Q348	R:R:Y323	28.253	4.51	No	Yes	0	8	9
23	R:R:N344	R:R:Q348	25.0691	2.64	No	No	0	8	8
24	L:L:L9	R:R:N344	23.463	19.22	No	No	0	0	8
25	L:L:L9	R:R:I341	13.574	8.56	No	No	0	0	6
26	R:R:I341	R:R:Q337	10.3619	8.23	No	No	0	6	4
27	R:R:L131	R:R:S127	31.8912	3	Yes	No	0	9	9
28	R:R:F353	R:R:S127	30.7815	2.64	Yes	No	0	5	9
29	R:R:F350	R:R:F353	23.9266	4.29	No	Yes	0	6	5
30	R:R:F346	R:R:F350	16.7346	8.57	No	No	0	6	6
31	R:R:F346	R:R:V119	15.5031	5.24	No	No	0	6	6
32	R:R:V119	R:R:Y342	14.2623	6.31	No	No	0	6	6
33	R:R:F191	R:R:W166	14.2623	6.01	No	Yes	0	6	7
34	R:R:L161	R:R:T157	29.6249	2.95	No	No	0	5	3
35	R:R:T157	R:R:W153	30.154	6.06	No	Yes	0	3	6
36	R:R:N154	R:R:W153	34.6022	4.52	No	Yes	0	8	6
37	R:R:F227	R:R:N154	20.8035	4.83	Yes	No	1	7	8
38	R:R:F227	R:R:L147	20.8316	4.87	Yes	Yes	1	7	6
39	R:R:L147	R:R:Y208	18.6824	4.69	Yes	No	1	6	7
40	R:R:R148	R:R:Y208	34.93	4.12	Yes	No	1	8	7
41	R:R:N363	R:R:R148	13.972	8.44	Yes	Yes	1	9	8
42	R:R:F227	R:R:I151	71.4567	10.05	Yes	Yes	1	7	8
43	R:R:I151	R:R:Y208	18.7573	4.84	Yes	No	1	8	7
44	R:R:N149	R:R:R148	16.7673	9.64	No	Yes	0	7	8
45	R:R:I144	R:R:N149	11.2141	11.33	No	No	0	7	7
46	R:R:E205	R:R:I151	54.2586	5.47	Yes	Yes	1	9	8
47	R:R:E205	R:R:H152	26.0711	7.39	Yes	Yes	1	9	8
48	R:R:E205	R:R:L318	25.9025	6.63	Yes	No	1	9	8
49	R:R:H152	R:R:Y359	26.1039	4.36	Yes	No	1	8	8
50	R:R:L318	R:R:Y359	24.6289	15.24	No	No	1	8	8
51	R:R:N154	R:R:W201	14.782	15.82	No	Yes	1	8	9
52	R:R:T158	R:R:W201	45.6103	3.64	No	Yes	1	8	9
53	R:R:N198	R:R:T158	50.9482	14.62	Yes	No	0	8	8
54	R:R:T197	R:R:W201	47.9281	3.64	Yes	Yes	1	8	9
55	R:R:C254	R:R:F256	13.6957	5.59	No	Yes	0	9	7
56	R:R:C184	R:R:C254	12.4643	7.28	No	No	0	9	9
57	R:R:T197	R:R:Y193	50.1147	8.74	Yes	Yes	1	8	8
58	R:R:I239	R:R:Y193	52.1187	12.09	No	Yes	0	7	8
59	R:R:I239	R:R:T189	51.2666	4.56	No	No	0	7	6
60	R:R:T189	R:R:W255	50.3957	4.85	No	Yes	0	6	9
61	R:R:T322	R:R:Y323	66.0158	3.75	Yes	Yes	6	8	9
62	R:R:L316	R:R:T322	63.5155	8.84	Yes	Yes	0	7	8
63	R:R:I321	R:R:L316	58.0184	4.28	No	Yes	0	6	7
64	R:R:I321	R:R:L283	47.1789	4.28	No	Yes	5	6	7
65	R:R:L283	R:R:L315	43.611	5.54	Yes	No	5	7	9
66	R:R:L315	R:R:L319	32.3969	8.3	No	No	5	9	8
67	R:R:G206	R:R:L319	31.3995	1.71	No	No	0	8	8
68	R:R:G206	R:R:N279	29.831	1.7	No	No	0	8	9
69	R:R:F282	R:R:N279	23.463	3.62	No	No	0	7	9
70	R:R:F282	R:R:H210	18.5888	16.97	No	No	0	7	8
71	R:R:H210	R:R:V214	15.2924	11.07	No	No	0	8	6
72	R:R:M215	R:R:V214	13.6302	3.04	No	No	0	4	6
73	R:R:M215	R:R:S218	10.2777	12.27	No	No	0	4	5
74	R:R:K246	R:R:W255	44.6645	17.4	Yes	Yes	2	5	9
75	R:R:V314	R:R:Y359	48.0217	3.79	No	No	0	7	8
76	R:R:K310	R:R:V314	37.0043	6.07	No	No	0	7	7
77	R:R:K307	R:R:K310	34.2136	10.06	Yes	No	0	6	7
78	R:R:K307	R:R:L294	17.273	2.82	Yes	No	0	6	6
79	R:R:L294	R:R:Q304	11.5512	15.97	No	No	0	6	5
80	R:R:I303	R:R:K307	11.5512	1.45	Yes	Yes	0	5	6
81	L:L:L18	R:R:F256	12.1834	3.65	Yes	Yes	3	0	7
82	R:R:W242	R:R:Y268	40.7501	26.04	Yes	No	2	8	8
83	R:R:K246	R:R:W242	41.6023	18.57	Yes	Yes	2	5	8
84	R:R:F227	R:R:W201	76.8647	5.01	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N2	R:R:K258	5.6	0	No	No	0	5	0	1
L:L:L5	R:R:Q269	3.99	0	Yes	No	0	6	0	1
L:L:S6	R:R:F340	3.96	0	No	No	0	7	0	1
L:L:I7	R:R:Y323	3.63	0	No	Yes	0	9	0	1
L:L:L9	R:R:I341	8.56	0	No	No	0	6	0	1
L:L:L9	R:R:N344	19.22	0	No	No	0	8	0	1
L:L:T10	R:R:Q348	5.67	0	No	No	0	8	0	1
L:L:F11	R:R:F191	4.29	0	No	No	0	6	0	1
L:L:F11	R:R:F256	5.36	0	No	Yes	0	7	0	1
L:L:H12	R:R:I341	5.3	0	No	No	0	6	0	1
L:L:L13	R:R:Y113	15.24	7	No	No	0	4	0	1
L:L:L14	R:R:F256	3.65	0	No	Yes	0	7	0	1
L:L:R15	R:R:G257	3	0	No	No	0	5	0	1
L:L:R15	R:R:K258	6.19	0	No	No	0	5	0	1
L:L:T16	R:R:Y113	3.75	7	No	No	0	4	0	1
L:L:L17	R:R:Y113	14.07	0	No	No	0	4	0	1
L:L:L18	R:R:V172	2.98	3	Yes	No	0	4	0	1
L:L:L18	R:R:H174	5.14	3	Yes	Yes	0	2	0	1
L:L:L18	R:R:H177	9	3	Yes	Yes	0	2	0	1
L:L:L18	R:R:F256	3.65	3	Yes	Yes	0	7	0	1
L:L:E19	R:R:H174	7.39	0	No	Yes	0	2	0	1
L:L:R22	R:R:H174	21.44	3	No	Yes	0	2	0	1
L:L:R22	R:R:E178	8.14	3	No	No	0	3	0	1
L:L:T23	R:R:R107	3.88	0	No	No	0	1	0	1
L:L:R29	R:R:N69	10.85	0	No	No	0	3	0	1
L:L:A30	R:R:P100	3.74	0	No	No	0	1	0	1
L:L:N33	R:R:F68	7.25	0	No	No	0	6	0	1
L:L:N33	R:R:Y95	6.98	0	No	No	0	5	0	1
L:L:N33	R:R:P100	3.26	0	No	No	0	1	0	1
L:L:F37	R:R:I93	3.77	0	No	Yes	0	7	0	1
L:L:F37	R:R:Y95	27.85	0	No	No	0	5	0	1
R:R:D45	R:R:W51	6.7	4	No	Yes	9	9	2	2
R:R:D45	R:R:I93	4.2	4	No	Yes	9	7	2	1
R:R:R81	R:R:W51	7	4	No	Yes	8	9	2	2
R:R:I93	R:R:W51	4.7	4	Yes	Yes	7	9	1	2
R:R:F68	R:R:N69	14.5	0	No	No	6	3	1	1
R:R:I93	R:R:R81	11.27	4	Yes	No	7	8	1	2
R:R:C98	R:R:Y95	20.16	8	Yes	No	9	5	2	1
R:R:F191	R:R:M165	8.71	0	No	No	6	5	1	2
R:R:F191	R:R:W166	6.01	0	No	Yes	6	7	1	2
R:R:V172	R:R:V176	3.21	0	No	Yes	4	2	1	2
R:R:E178	R:R:H174	8.62	3	No	Yes	3	2	1	1
R:R:H177	R:R:Q253	11.13	3	Yes	No	2	4	1	2
R:R:F256	R:R:H177	20.36	3	Yes	Yes	7	2	1	1
R:R:G257	R:R:H177	3.18	3	No	Yes	5	2	1	1
R:R:G257	R:R:Q253	4.93	3	No	No	5	4	1	2
R:R:C254	R:R:F256	5.59	0	No	Yes	9	7	2	1
R:R:Q269	R:R:Y266	15.78	0	No	No	6	6	1	2
R:R:G270	R:R:Q269	4.93	0	No	No	5	6	2	1
R:R:T322	R:R:Y323	3.75	6	Yes	Yes	8	9	2	1
R:R:Q351	R:R:T322	5.67	6	No	Yes	9	8	2	2
R:R:Q348	R:R:Y323	4.51	0	No	Yes	8	9	1	1
R:R:Q351	R:R:Y323	14.65	6	No	Yes	9	9	2	1
R:R:F340	R:R:Q337	8.2	0	No	No	7	4	1	2
R:R:I341	R:R:Q337	8.23	0	No	No	6	4	1	2
R:R:N344	R:R:Q348	2.64	0	No	No	8	8	1	1
L:L:R29	R:R:V71	2.62	0	No	No	0	4	0	1
L:L:I36	R:R:F68	2.51	0	No	No	0	6	0	1
L:L:L20	R:R:R107	2.43	0	No	No	0	1	0	1
R:R:F326	R:R:F340	2.14	0	No	No	8	7	2	1
R:R:L102	R:R:P100	1.64	0	No	No	1	1	2	1
L:L:L5	R:R:V328	1.49	0	Yes	No	0	5	0	1
L:L:L17	R:R:L117	1.38	0	No	No	0	4	0	1
L:L:L20	R:R:D110	1.36	0	No	No	0	3	0	1
R:R:D110	R:R:L111	1.36	0	No	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TRY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	337
Number of Links	365
Number of Hubs	37
Number of Links mediated by Hubs	140
Number of Communities	12
Number of Nodes involved in Communities	72
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	46675
Length Of Smallest Path	3
Average Path Length	18.9191
Length of Longest Path	44
Minimum Path Strength	1.225
Average Path Strength	7.16607
Maximum Path Strength	24.005
Minimum Path Correlation	0.7
Average Path Correlation	0.970365
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	63.7406
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.7439
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • cellular process • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of biological process • long-term synaptic potentiation • synaptic signaling • regulation of biological quality • positive regulation of cellular process • regulation of synaptic plasticity • trans-synaptic signaling • regulation of signaling • cell-cell signaling • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse • distal axon • cell junction • neuron projection terminus • binding • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • G protein-coupled receptor binding • hormone receptor binding • neuropeptide receptor binding • enzyme regulator activity • molecular function inhibitor activity • histone deacetylase inhibitor activity • enzyme inhibitor activity • histone deacetylase regulator activity • corticotropin-releasing hormone receptor 1 binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • regulation of growth • regulation of cellular component organization • growth • positive regulation of biological process • positive regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • positive regulation of growth • cellular component organization or biogenesis • positive regulation of cellular process • multicellular organismal process • response to stress • multicellular organismal response to stress • response to pain • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of biological process • negative regulation of appetite • regulation of response to food • regulation of response to stimulus • response to food • response to chemical • regulation of biological quality • regulation of appetite • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • aerobic respiration • cellular respiration • energy derivation by oxidation of organic compounds • metabolic process • generation of precursor metabolites and energy • interleukin-6 production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-6 production • regulation of interleukin-6 production • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of defense response • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • regulation of response to stress • behavioral fear response • defense response • positive regulation of behavioral fear response • behavior • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of DNA replication • regulation of primary metabolic process • nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • primary metabolic process • DNA metabolic process • nucleic acid metabolic process • DNA replication • positive regulation of DNA metabolic process • regulation of DNA metabolic process • regulation of DNA replication • regulation of localization • regulation of hormone secretion • negative regulation of signaling • transport • negative regulation of transport • hormone secretion • negative regulation of cell communication • localization • negative regulation of secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to endogenous stimulus • response to glucocorticoid • drinking behavior • feeding behavior • positive regulation of protein metabolic process • positive regulation of translation • protein biosynthetic process • post-transcriptional regulation of gene expression • protein metabolic process • regulation of protein metabolic process • translation • regulation of translation • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • startle response • nervous system process • neuromuscular process • response to external stimulus • response to auditory stimulus • response to mechanical stimulus • response to abiotic stimulus • positive regulation of cell communication • nitrogen compound transport • regulation of system process • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • positive regulation of peptide hormone secretion • endocrine hormone secretion • regulation of endocrine process • regulation of peptide secretion • positive regulation of secretion by cell • regulation of corticotropin secretion • peptide secretion • positive regulation of hormone secretion • positive regulation of secretion • amide transport • positive regulation of peptide secretion • corticotropin secretion • regulation of peptide transport • peptide transport • endocrine process • positive regulation of transport • peptide hormone secretion • positive regulation of signaling • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • sensory perception • sensory perception of sound • sensory perception of mechanical stimulus • regulation of vascular permeability • positive regulation of vascular permeability • biological process involved in intraspecies interaction between organisms • social behavior • learning • learning or memory • cognition • associative learning • trans-synaptic signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • response to oxidative stress • negative regulation of feeding behavior • negative regulation of behavior • regulation of feeding behavior • negative regulation of multicellular organismal process • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • positive regulation of DNA-templated transcription • RNA metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • system development • negative regulation of cell size • regulation of cellular component size • regulation of cell size • heart process • regulation of heart contraction • positive regulation of blood circulation • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of heart contraction • regulation of blood circulation • regulation of striated muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • heart contraction • response to estradiol • response to oxygen-containing compound • regulation of blood pressure • negative regulation of blood pressure • cell body • perikaryon • neuronal cell body • main axon • varicosity • extracellular region • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • heart development • animal organ development • circulatory system development • rhythmic process • entrainment of circadian clock • circadian rhythm • regulation of circadian rhythm • cellular response to nitrogen compound • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • cellular response to acetylcholine • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • skeletal system development • cranial skeletal system development • action potential • regulation of membrane potential • pigment cell differentiation • regulation of developmental process • developmental pigmentation • regulation of pigment cell differentiation • regulation of cell differentiation • pigmentation • melanocyte differentiation • regulation of melanocyte differentiation • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to pH • cellular response to pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • endothelin receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • establishment of protein localization • positive regulation of establishment of protein localization • positive regulation of insulin secretion • intracellular protein localization • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • positive regulation of protein localization • regulation of protein localization • protein localization to extracellular region • positive regulation of protein transport • regulation of establishment of protein localization • regulation of protein transport • positive regulation of protein secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • ligand-gated ion channel signaling pathway • phospholipase C-activating dopamine receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • photoreceptor inner segment • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13324
Sequence	>7TRY_nogp_Chain_R N T T L D Q I G T C W P R E R P C P E Y F N G V K Y N T T R N A Y R E C L T W A S K I N Y S Q C E P I L Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L R S I R C L R N V I H W N L I T T F I L R N V M W F L L Q L V D H E V H E S N E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M T Y S T E R L R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E N E Q C W F G K E P L V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E D D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R S A V R K R W H R W Q D H H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6PB1	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	2.8	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	6PB1 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	7TRY	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-G11)/β1/γ2	3.7	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TRY (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		3.7	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TS0	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1L-Go)/β1/γ2	2.8	2022-11-09	doi.org/10.1038/s41467-022-33851-3
	7TS0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2022-11-09	doi.org/10.1038/s41467-022-33851-3

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