psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I7	L:L:L5	5.71	Yes	No	0	0	0
2	L:L:L5	R:R:F327	4.87	No	No	0	0	5
3	L:L:S6	R:R:N344	8.94	No	No	0	0	8
4	L:L:I7	R:R:F199	3.77	Yes	Yes	1	0	8
5	L:L:I7	R:R:Q269	6.86	Yes	Yes	1	0	6
6	L:L:I7	R:R:Y323	3.63	Yes	Yes	1	0	9
7	L:L:D8	L:L:F11	5.97	No	Yes	1	0	0
8	L:L:D8	L:L:R15	3.57	No	Yes	1	0	0
9	L:L:D8	R:R:Q269	6.53	No	Yes	1	0	6
10	L:L:L13	L:L:L9	6.92	No	Yes	0	0	0
11	L:L:L9	R:R:F340	3.65	Yes	Yes	6	0	7
12	L:L:L9	R:R:N344	4.12	Yes	No	6	0	8
13	L:L:L9	R:R:S345	3	Yes	No	0	0	6
14	L:L:L9	R:R:Q348	3.99	Yes	No	0	0	8
15	L:L:L14	L:L:T10	2.95	No	No	0	0	0
16	L:L:T10	R:R:W166	3.64	No	Yes	0	0	7
17	L:L:T10	R:R:Q348	2.83	No	No	0	0	8
18	L:L:F11	L:L:R15	4.28	Yes	Yes	1	0	0
19	L:L:F11	R:R:F191	4.29	Yes	Yes	0	0	6
20	L:L:F11	R:R:N192	8.46	Yes	No	1	0	8
21	L:L:F11	R:R:F256	10.72	Yes	Yes	1	0	7
22	L:L:H12	L:L:T16	6.85	No	No	0	0	0
23	L:L:L13	R:R:I341	2.85	No	No	0	0	6
24	L:L:L14	R:R:Q170	6.65	No	No	0	0	6
25	L:L:R15	R:R:F256	3.21	Yes	Yes	1	0	7
26	L:L:R15	R:R:K258	11.14	Yes	No	0	0	5
27	L:L:T16	R:R:Y113	12.48	No	No	0	0	4
28	L:L:L18	R:R:H177	5.14	No	No	0	0	2
29	L:L:Q24	L:L:R27	12.85	No	No	0	0	0
30	L:L:S25	R:R:H174	6.97	No	No	0	0	2
31	L:L:Q26	R:R:L102	3.99	No	No	0	0	1
32	L:L:R29	R:R:V71	3.92	No	Yes	0	0	4
33	L:L:A30	R:R:L102	3.15	No	No	0	0	1
34	L:L:E31	L:L:R34	3.49	No	No	0	0	0
35	L:L:N33	R:R:N69	6.81	Yes	No	0	0	3
36	L:L:N33	R:R:V71	2.96	Yes	Yes	8	0	4
37	L:L:N33	R:R:Y73	3.49	Yes	Yes	8	0	4
38	R:R:C64	R:R:C98	7.28	No	No	9	9	9
39	R:R:F68	R:R:P65	5.78	Yes	No	0	6	8
40	R:R:K72	R:R:Y67	13.14	No	No	0	1	5
41	R:R:F68	R:R:N69	12.08	Yes	No	0	6	3
42	R:R:F68	R:R:Y73	5.16	Yes	Yes	0	6	4
43	R:R:V71	R:R:Y73	8.83	Yes	Yes	8	4	4
44	R:R:K108	R:R:Q106	5.42	No	No	0	3	2
45	R:R:D110	R:R:R107	4.76	No	No	0	3	1
46	R:R:H112	R:R:Y109	8.71	No	Yes	10	4	3
47	R:R:I338	R:R:Y109	9.67	No	Yes	10	3	3
48	R:R:D110	R:R:R114	14.29	No	No	0	3	2
49	R:R:L111	R:R:R114	7.29	No	No	0	1	2
50	R:R:I115	R:R:L111	2.85	No	No	0	4	1
51	R:R:H112	R:R:I338	7.95	No	No	10	4	3
52	R:R:H112	R:R:Y342	6.53	No	No	0	4	6
53	R:R:I115	R:R:Y342	9.67	No	No	0	4	6
54	R:R:L117	R:R:Y121	5.86	No	Yes	0	4	5
55	R:R:H124	R:R:N120	7.65	Yes	No	2	6	7
56	R:R:N120	R:R:W166	9.04	No	Yes	2	7	7
57	R:R:N120	R:R:S349	7.45	No	No	2	7	9
58	R:R:W166	R:R:Y121	8.68	Yes	Yes	2	7	5
59	R:R:F167	R:R:Y121	4.13	No	Yes	2	6	5
60	R:R:Q170	R:R:Y121	11.27	No	Yes	2	6	5
61	R:R:F350	R:R:G123	9.03	Yes	No	0	6	8
62	R:R:H124	R:R:N163	8.93	Yes	No	0	6	7
63	R:R:H124	R:R:W166	27.51	Yes	Yes	2	6	7
64	R:R:H124	R:R:S349	4.18	Yes	No	2	6	9
65	R:R:F353	R:R:V126	5.24	Yes	No	0	5	5
66	R:R:N163	R:R:V128	4.43	No	No	0	7	6
67	R:R:A130	R:R:S356	3.42	No	No	0	6	8
68	R:R:I156	R:R:L131	5.71	No	No	4	7	9
69	R:R:I160	R:R:L131	5.71	Yes	No	4	7	9
70	R:R:L131	R:R:S356	6.01	No	No	0	9	8
71	R:R:A134	R:R:I156	3.25	No	No	0	8	7
72	R:R:A134	R:R:S356	3.42	No	No	0	8	8
73	R:R:A134	R:R:C360	3.61	No	Yes	0	8	7
74	R:R:F135	R:R:L139	4.87	No	No	4	5	2
75	R:R:F135	R:R:W153	11.02	No	Yes	4	5	6
76	R:R:F135	R:R:I160	3.77	No	Yes	4	5	7
77	R:R:C360	R:R:L137	3.17	Yes	No	0	7	8
78	R:R:F138	R:R:W153	4.01	Yes	Yes	0	7	6
79	R:R:C360	R:R:F138	4.19	Yes	Yes	0	7	7
80	R:R:L139	R:R:W153	14.81	No	Yes	4	2	6
81	R:R:A369	R:R:L141	4.73	No	Yes	0	7	6
82	R:R:R142	R:R:R145	7.46	No	No	0	7	6
83	R:R:I144	R:R:N149	9.91	No	No	0	7	7
84	R:R:C146	R:R:N149	3.15	No	No	0	7	7
85	R:R:I151	R:R:L147	7.14	Yes	Yes	1	8	6
86	R:R:L147	R:R:Y208	8.21	Yes	Yes	1	6	7
87	R:R:K224	R:R:L147	4.23	No	Yes	0	5	6
88	R:R:F227	R:R:L147	4.87	Yes	Yes	1	7	6
89	R:R:H152	R:R:R148	15.8	No	No	1	8	8
90	R:R:E205	R:R:R148	9.3	Yes	No	1	9	8
91	R:R:R148	R:R:Y208	8.23	No	Yes	1	8	7
92	R:R:I151	R:R:W201	4.7	Yes	Yes	1	8	9
93	R:R:I151	R:R:V204	4.61	Yes	Yes	1	8	7
94	R:R:E205	R:R:I151	5.47	Yes	Yes	1	9	8
95	R:R:I151	R:R:Y208	4.84	Yes	Yes	1	8	7
96	R:R:F227	R:R:I151	3.77	Yes	Yes	1	7	8
97	R:R:E205	R:R:H152	7.39	Yes	No	1	9	8
98	R:R:N154	R:R:W153	4.52	No	Yes	0	8	6
99	R:R:T157	R:R:W153	7.28	No	Yes	0	3	6
100	R:R:N154	R:R:W201	13.56	No	Yes	0	8	9
101	R:R:L155	R:R:T158	2.95	No	No	0	8	8
102	R:R:F159	R:R:L155	6.09	No	No	0	9	8
103	R:R:I156	R:R:I160	2.94	No	Yes	4	7	7
104	R:R:L161	R:R:T157	2.95	No	No	0	5	3
105	R:R:N198	R:R:T158	4.39	Yes	No	0	8	8
106	R:R:T158	R:R:W201	3.64	No	Yes	0	8	9
107	R:R:F159	R:R:N198	18.12	No	Yes	0	9	8
108	R:R:F159	R:R:G352	6.02	No	No	0	9	9
109	R:R:F194	R:R:L161	13.4	No	No	0	6	5
110	R:R:R162	R:R:V195	13.08	No	No	0	8	6
111	R:R:N198	R:R:R162	9.64	Yes	No	0	8	8
112	R:R:I187	R:R:M165	4.37	No	No	0	6	5
113	R:R:I190	R:R:M165	5.83	No	No	0	4	5
114	R:R:F191	R:R:M165	3.73	Yes	No	0	6	5
115	R:R:F167	R:R:W166	10.02	No	Yes	2	6	7
116	R:R:Q170	R:R:W166	21.9	No	Yes	2	6	7
117	R:R:F191	R:R:W166	6.01	Yes	Yes	0	6	7
118	R:R:I187	R:R:L169	4.28	No	No	0	6	6
119	R:R:L169	R:R:T188	2.95	No	No	0	6	7
120	R:R:F191	R:R:L169	3.65	Yes	No	0	6	6
121	R:R:V172	R:R:V176	3.21	No	Yes	7	4	2
122	R:R:C184	R:R:V172	3.42	No	No	7	9	4
123	R:R:D173	R:R:E175	5.2	No	No	0	3	1
124	R:R:D173	R:R:V176	4.38	No	Yes	0	3	2
125	R:R:E175	R:R:H174	9.85	No	No	0	1	2
126	R:R:E181	R:R:V176	8.56	No	Yes	7	3	2
127	R:R:V176	R:R:W183	4.9	Yes	No	7	2	1
128	R:R:C184	R:R:V176	3.42	No	Yes	7	9	2
129	R:R:H177	R:R:Q253	14.84	No	No	0	2	4
130	R:R:F256	R:R:H177	4.53	Yes	No	0	7	2
131	R:R:E181	R:R:W183	14.17	No	No	7	3	1
132	R:R:C184	R:R:C254	7.28	No	No	0	9	9
133	R:R:N251	R:R:R185	7.23	No	No	3	5	6
134	R:R:R185	R:R:W255	22.99	No	Yes	3	6	9
135	R:R:C186	R:R:I190	3.27	No	No	0	4	4
136	R:R:F256	R:R:T188	5.19	Yes	No	0	7	7
137	R:R:F191	R:R:V195	5.24	Yes	No	0	6	6
138	R:R:N192	R:R:W242	6.78	No	Yes	1	8	8
139	R:R:N192	R:R:Y268	5.81	No	Yes	1	8	8
140	R:R:F194	R:R:Y193	5.16	No	Yes	0	6	8
141	R:R:T197	R:R:Y193	8.74	No	Yes	1	8	8
142	R:R:W232	R:R:Y193	3.86	No	Yes	1	9	8
143	R:R:P235	R:R:Y193	4.17	Yes	Yes	1	9	8
144	R:R:F236	R:R:Y193	16.5	No	Yes	0	4	8
145	R:R:I239	R:R:Y193	9.67	No	Yes	0	7	8
146	R:R:F200	R:R:V196	3.93	Yes	Yes	1	5	6
147	R:R:P235	R:R:V196	3.53	Yes	Yes	1	9	6
148	R:R:I239	R:R:V196	3.07	No	Yes	0	7	6
149	R:R:V196	R:R:Y268	3.79	Yes	Yes	1	6	8
150	R:R:I272	R:R:V196	3.07	No	Yes	1	7	6
151	R:R:T197	R:R:W232	4.85	No	No	1	8	9
152	R:R:P235	R:R:T197	5.25	Yes	No	1	9	8
153	R:R:M202	R:R:N198	5.61	No	Yes	0	9	8
154	R:R:F199	R:R:I272	13.82	Yes	No	1	8	7
155	R:R:F199	R:R:L276	7.31	Yes	No	1	8	7
156	R:R:F199	R:R:Y323	10.32	Yes	Yes	1	8	9
157	R:R:F200	R:R:I234	3.77	Yes	Yes	1	5	3
158	R:R:F200	R:R:P235	7.22	Yes	Yes	1	5	9
159	R:R:V204	R:R:W201	6.13	Yes	Yes	1	7	9
160	R:R:G231	R:R:W201	8.44	No	Yes	0	8	9
161	R:R:W201	R:R:W232	12.18	Yes	No	1	9	9
162	R:R:M202	R:R:Q351	5.44	No	No	0	9	9
163	R:R:C207	R:R:F203	8.38	No	Yes	0	5	7
164	R:R:F203	R:R:V275	3.93	Yes	No	0	7	7
165	R:R:F203	R:R:I278	5.02	Yes	No	0	7	5
166	R:R:F203	R:R:N279	7.25	Yes	No	0	7	9
167	R:R:F227	R:R:V204	5.24	Yes	Yes	1	7	7
168	R:R:I230	R:R:V204	3.07	No	Yes	0	4	7
169	R:R:E205	R:R:L318	10.6	Yes	No	0	9	8
170	R:R:F227	R:R:Y208	5.16	Yes	Yes	1	7	7
171	R:R:I213	R:R:L209	4.28	No	No	5	7	8
172	R:R:I286	R:R:L209	2.85	No	No	5	8	8
173	R:R:H210	R:R:V214	15.22	No	No	0	8	6
174	R:R:F282	R:R:H210	9.05	No	No	0	7	8
175	R:R:I213	R:R:I286	4.42	No	No	5	7	8
176	R:R:I213	R:R:I289	4.42	No	No	5	7	7
177	R:R:M215	R:R:V214	3.04	No	No	0	4	6
178	R:R:M215	R:R:Y217	14.37	No	No	0	4	7
179	R:R:R223	R:R:T216	7.76	Yes	No	0	5	7
180	R:R:S218	R:R:T219	3.2	No	No	11	5	5
181	R:R:L222	R:R:S218	6.01	No	No	11	4	5
182	R:R:L222	R:R:T219	4.42	No	No	11	4	5
183	R:R:I230	R:R:L226	2.85	No	No	0	4	3
184	R:R:C233	R:R:F229	8.38	No	No	0	7	3
185	R:R:F229	R:R:I234	5.02	No	Yes	0	3	3
186	R:R:I230	R:R:I234	4.42	No	Yes	0	4	3
187	R:R:I234	R:R:P235	3.39	Yes	Yes	1	3	9
188	R:R:I244	R:R:V240	3.07	No	No	0	4	3
189	R:R:D265	R:R:W242	6.7	No	Yes	1	6	8
190	R:R:I267	R:R:W242	8.22	No	Yes	0	7	8
191	R:R:W242	R:R:Y268	13.5	Yes	Yes	1	8	8
192	R:R:E250	R:R:K246	8.1	No	No	3	6	5
193	R:R:K246	R:R:W255	8.12	No	Yes	3	5	9
194	R:R:K246	R:R:V264	3.04	No	Yes	3	5	4
195	R:R:L247	R:R:N251	4.12	No	No	3	1	5
196	R:R:L247	R:R:W255	6.83	No	Yes	3	1	9
197	R:R:D262	R:R:E250	14.29	No	No	0	4	6
198	R:R:E250	R:R:V264	8.56	No	Yes	3	6	4
199	R:R:N251	R:R:W255	4.52	No	Yes	3	5	9
200	R:R:E252	R:R:E259	3.81	No	Yes	0	3	3
201	R:R:G257	R:R:Q253	4.93	No	No	0	5	4
202	R:R:E259	R:R:Q253	6.37	Yes	No	0	3	4
203	R:R:E259	R:R:P260	4.72	Yes	No	0	3	5
204	R:R:D262	R:R:E259	6.5	No	Yes	0	4	3
205	R:R:L263	R:R:Y266	3.52	No	No	0	3	6
206	R:R:D265	R:R:Y268	11.49	No	Yes	1	6	8
207	R:R:D265	R:R:Q269	7.83	No	Yes	1	6	6
208	R:R:Q269	R:R:Y268	12.4	Yes	Yes	1	6	8
209	R:R:G270	R:R:P271	4.06	No	No	0	5	9
210	R:R:I272	R:R:L276	2.85	No	No	1	7	7
211	R:R:F327	R:R:I273	8.79	No	No	0	5	4
212	R:R:I278	R:R:L274	4.28	No	No	0	5	3
213	R:R:L276	R:R:M324	2.83	No	Yes	1	7	5
214	R:R:F282	R:R:I278	5.02	No	No	0	7	5
215	R:R:L319	R:R:N279	4.12	No	No	0	8	9
216	R:R:F280	R:R:I321	5.02	No	Yes	1	5	6
217	R:R:F280	R:R:M324	7.46	No	Yes	1	5	5
218	R:R:L283	R:R:L315	4.15	No	No	0	7	9
219	R:R:I321	R:R:L283	2.85	Yes	No	0	6	7
220	R:R:N285	R:R:R288	7.23	No	No	5	6	6
221	R:R:I289	R:R:N285	5.66	No	No	5	7	6
222	R:R:I289	R:R:R288	3.76	No	No	5	7	6
223	R:R:L294	R:R:S297	3	No	No	0	6	4
224	R:R:L294	R:R:Q304	6.65	No	Yes	0	6	5
225	R:R:Q304	R:R:T298	5.67	Yes	No	0	5	5
226	R:R:I303	R:R:S300	6.19	No	No	0	5	6
227	R:R:E301	R:R:Q304	7.65	No	Yes	0	5	5
228	R:R:R306	R:R:T302	3.88	No	No	0	4	5
229	R:R:L316	R:R:T312	2.95	No	No	0	7	7
230	R:R:I321	R:R:L316	4.28	Yes	No	0	6	7
231	R:R:L318	R:R:Y359	16.41	No	No	0	8	8
232	R:R:I321	R:R:L319	2.85	Yes	No	0	6	8
233	R:R:I321	R:R:M324	4.37	Yes	Yes	1	6	5
234	R:R:T322	R:R:Y323	3.75	No	Yes	1	8	9
235	R:R:L347	R:R:T322	2.95	No	No	0	5	8
236	R:R:Q351	R:R:T322	4.25	No	No	1	9	8
237	R:R:Q348	R:R:Y323	3.38	No	Yes	0	8	9
238	R:R:Q351	R:R:Y323	7.89	No	Yes	1	9	9
239	R:R:F326	R:R:N329	9.67	No	Yes	6	8	5
240	R:R:F326	R:R:F340	7.5	No	Yes	6	8	7
241	R:R:F327	R:R:V328	5.24	No	No	0	5	5
242	R:R:N329	R:R:P330	6.52	Yes	No	0	5	5
243	R:R:N329	R:R:S336	5.96	Yes	No	0	5	3
244	R:R:F340	R:R:N329	9.67	Yes	Yes	6	7	5
245	R:R:D333	R:R:S336	7.36	No	No	0	4	3
246	R:R:F340	R:R:Q337	4.68	Yes	No	0	7	4
247	R:R:F340	R:R:I341	3.77	Yes	No	0	7	6
248	R:R:F340	R:R:N344	7.25	Yes	No	6	7	8
249	R:R:F343	R:R:L347	7.31	No	No	0	4	5
250	R:R:F346	R:R:F350	8.57	No	Yes	0	6	6
251	R:R:F350	R:R:F353	3.22	Yes	Yes	0	6	5
252	R:R:F353	R:R:V357	6.55	Yes	No	0	5	5
253	R:R:F354	R:R:F358	4.29	No	No	0	6	7
254	R:R:V355	R:R:Y359	3.79	No	No	0	9	8
255	R:R:F358	R:R:F362	9.65	No	No	0	7	5
256	R:R:C360	R:R:F361	5.59	Yes	No	0	7	6
257	R:R:F362	R:R:R367	4.28	No	No	0	5	7
258	R:R:E365	R:R:N363	5.26	No	No	0	8	9
259	R:R:H375	R:R:R371	3.39	No	No	0	4	5
260	R:R:W374	R:R:W377	8.43	No	No	0	4	4
261	R:R:C125	R:R:F167	2.79	No	No	0	5	6
262	R:R:C254	R:R:F256	2.79	No	Yes	0	9	7
263	R:R:P100	R:R:Y73	2.78	No	Yes	0	1	4
264	R:R:A130	R:R:F353	2.77	No	Yes	0	6	5
265	R:R:E365	R:R:I144	2.73	No	No	0	8	7
266	R:R:D104	R:R:L102	2.71	No	No	0	1	1
267	R:R:D379	R:R:L383	2.71	No	No	0	2	4
268	L:L:S4	R:R:F340	2.64	No	Yes	0	0	7
269	R:R:F353	R:R:S127	2.64	Yes	No	0	5	9
270	R:R:F138	R:R:V366	2.62	Yes	No	0	7	8
271	R:R:R223	R:R:T211	2.59	Yes	No	0	5	7
272	R:R:H210	R:R:N285	2.55	No	No	0	8	6
273	R:R:V264	R:R:Y249	2.52	Yes	No	0	4	4
274	R:R:V314	R:R:Y359	2.52	No	No	0	7	8
275	R:R:F200	R:R:I238	2.51	Yes	No	0	5	7
276	R:R:M291	R:R:R295	2.48	No	No	0	4	4
277	R:R:K372	R:R:R376	2.48	No	No	0	6	5
278	R:R:F350	R:R:L122	2.44	Yes	No	0	6	6
279	R:R:F343	R:R:L325	2.44	No	No	0	4	6
280	L:L:L20	R:R:R107	2.43	No	No	0	0	1
281	R:R:L141	R:R:R373	2.43	Yes	No	0	6	4
282	R:R:L147	R:R:R223	2.43	Yes	Yes	0	6	5
283	R:R:T189	R:R:W255	2.43	No	Yes	0	6	9
284	R:R:I341	R:R:Y113	2.42	No	No	0	6	4
285	R:R:F138	R:R:N149	2.42	Yes	No	0	7	7
286	R:R:I244	R:R:Y248	2.42	No	No	0	4	1
287	L:L:L17	R:R:Y113	2.34	No	No	0	0	4
288	R:R:Q304	R:R:R295	2.34	Yes	No	0	5	4
289	R:R:E220	R:R:R223	2.33	No	Yes	0	5	5
290	R:R:L228	R:R:W201	2.28	No	Yes	0	5	9
291	R:R:Q337	R:R:Y109	2.25	No	Yes	0	4	3
292	R:R:Q269	R:R:Y266	2.25	Yes	No	0	6	6
293	R:R:E301	R:R:Y305	2.24	No	No	0	5	5
294	R:R:Q378	R:R:W374	2.19	No	No	0	6	4
295	L:L:F37	R:R:F68	2.14	No	Yes	0	0	6
296	R:R:F350	R:R:F354	2.14	Yes	No	0	6	6
297	R:R:R373	R:R:R376	2.13	No	No	0	4	5
298	R:R:C64	R:R:P65	1.88	No	No	9	9	8
299	R:R:C98	R:R:P65	1.88	No	No	9	9	8
300	R:R:G245	R:R:V264	1.84	No	Yes	0	4	4
301	R:R:P317	R:R:V355	1.77	No	No	0	7	9
302	R:R:G245	R:R:I244	1.76	No	No	0	4	4
303	R:R:G320	R:R:M202	1.75	No	No	0	9	9
304	R:R:A116	R:R:S345	1.71	No	No	0	7	6
305	R:R:G206	R:R:L209	1.71	No	No	0	8	8
306	R:R:G206	R:R:L319	1.71	No	No	0	8	8
307	R:R:G364	R:R:N363	1.7	No	No	0	5	9
308	R:R:A243	R:R:T189	1.68	No	No	0	4	6
309	R:R:G270	R:R:Q269	1.64	No	Yes	0	5	6
310	R:R:G331	R:R:Q337	1.64	No	No	0	3	4
311	L:L:N2	L:L:P3	1.63	No	No	0	0	0
312	R:R:A308	R:R:M291	1.61	No	No	0	7	4
313	R:R:V128	R:R:V132	1.6	No	No	0	6	3
314	R:R:A311	R:R:L290	1.58	No	No	0	8	7
315	R:R:E99	R:R:P100	1.57	No	No	0	1	1
316	R:R:I160	R:R:V164	1.54	Yes	No	0	7	4
317	R:R:L383	R:R:S382	1.5	No	No	0	4	4
318	R:R:L136	R:R:V132	1.49	No	No	0	2	3
319	R:R:L141	R:R:V366	1.49	Yes	No	0	6	8
320	R:R:L141	R:R:V370	1.49	Yes	No	0	6	4
321	R:R:L168	R:R:V164	1.49	No	No	0	4	4
322	R:R:L313	R:R:V309	1.49	No	No	0	6	6
323	R:R:N154	R:R:V150	1.48	No	No	0	8	5
324	L:L:T23	R:R:D104	1.45	No	No	0	0	1
325	R:R:E181	R:R:S179	1.44	No	No	0	3	1
326	R:R:F236	R:R:P237	1.44	No	No	0	4	4
327	L:L:Q26	R:R:V71	1.43	No	Yes	0	0	4
328	L:L:I36	L:L:N33	1.42	No	Yes	0	0	0
329	L:L:E19	L:L:T23	1.41	No	No	0	0	0
330	R:R:L277	R:R:M324	1.41	No	Yes	0	3	5
331	R:R:K307	R:R:L294	1.41	No	No	0	6	6
332	L:L:P3	R:R:Y266	1.39	No	No	0	0	6
333	R:R:D104	R:R:K105	1.38	No	No	0	1	3
334	R:R:L313	R:R:L316	1.38	No	No	0	6	7
335	L:L:I35	L:L:Q32	1.37	No	No	0	0	0
336	R:R:E252	R:R:N180	1.31	No	No	0	3	5
337	R:R:R185	R:R:V182	1.31	No	No	0	6	3
338	R:R:R288	R:R:T292	1.29	No	No	0	6	6
339	R:R:K108	R:R:Y109	1.19	No	Yes	0	3	3
340	L:L:E19	L:L:R22	1.16	No	No	0	0	0
341	L:L:R22	R:R:E178	1.16	No	No	0	0	3
342	L:L:R22	R:R:H174	1.13	No	No	0	0	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:I7	4.9925	4	1	0
2	L:L:L9	4.336	5	6	0
3	L:L:F11	6.744	5	1	0
4	L:L:R15	5.55	4	1	0
5	L:L:N33	3.67	4	8	0
6	R:R:F68	6.29	4	0	6
7	R:R:V71	4.285	4	8	4
8	R:R:Y73	5.065	4	8	4
9	R:R:Y109	5.455	4	10	3
10	R:R:Y121	7.485	4	2	5
11	R:R:H124	12.0675	4	2	6
12	R:R:F138	3.31	4	0	7
13	R:R:L141	2.535	4	0	6
14	R:R:L147	5.376	5	1	6
15	R:R:I151	5.08833	6	1	8
16	R:R:W153	8.328	5	4	6
17	R:R:I160	3.49	4	4	7
18	R:R:W166	12.4	7	2	7
19	R:R:V176	4.894	5	7	2
20	R:R:F191	4.584	5	0	6
21	R:R:Y193	8.01667	6	1	8
22	R:R:V196	3.478	5	1	6
23	R:R:N198	9.44	4	0	8
24	R:R:F199	8.805	4	1	8
25	R:R:F200	4.3575	4	1	5
26	R:R:W201	7.27571	7	1	9
27	R:R:F203	6.145	4	0	7
28	R:R:V204	4.7625	4	1	7
29	R:R:E205	8.19	4	1	9
30	R:R:Y208	6.61	4	1	7
31	R:R:R223	3.7775	4	0	5
32	R:R:F227	4.76	4	1	7
33	R:R:I234	4.15	4	1	3
34	R:R:P235	4.712	5	1	9
35	R:R:W242	8.8	4	1	8
36	R:R:W255	8.978	5	3	9
37	R:R:F256	5.288	5	1	7
38	R:R:E259	5.35	4	0	3
39	R:R:V264	3.99	4	3	4
40	R:R:Y268	9.398	5	1	8
41	R:R:Q269	6.25167	6	1	6
42	R:R:Q304	5.5775	4	0	5
43	R:R:I321	3.874	5	1	6
44	R:R:Y323	5.794	5	1	9
45	R:R:M324	4.0175	4	1	5
46	R:R:N329	7.955	4	6	5
47	R:R:F340	5.59429	7	6	7
48	R:R:F350	5.08	5	0	6
49	R:R:F353	4.084	5	0	5
50	R:R:C360	4.14	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I7	R:R:Y323	10.7201	3.63	Yes	Yes	1	0	9
2	R:R:Q348	R:R:Y323	38.3119	3.38	No	Yes	0	8	9
3	L:L:L9	R:R:Q348	46.692	3.99	Yes	No	0	0	8
4	L:L:D8	R:R:Q269	33.9524	6.53	No	Yes	1	0	6
5	L:L:I7	R:R:Q269	31.9374	6.86	Yes	Yes	1	0	6
6	L:L:D8	L:L:F11	17.1967	5.97	No	Yes	1	0	0
7	L:L:D8	L:L:R15	15.4185	3.57	No	Yes	1	0	0
8	L:L:L9	R:R:F340	33.2606	3.65	Yes	Yes	6	0	7
9	L:L:T10	R:R:Q348	21.9137	2.83	No	No	0	0	8
10	L:L:T10	R:R:W166	21.1941	3.64	No	Yes	0	0	7
11	L:L:F11	R:R:F191	49.422	4.29	Yes	Yes	0	0	6
12	R:R:Q269	R:R:Y268	17.9581	12.4	Yes	Yes	1	6	8
13	R:R:N192	R:R:Y268	25.9344	5.81	No	Yes	1	8	8
14	L:L:F11	R:R:F256	74.2606	10.72	Yes	Yes	1	0	7
15	L:L:R15	R:R:F256	14.7778	3.21	Yes	Yes	1	0	7
16	R:R:I341	R:R:Y113	10.6737	2.42	No	No	0	6	4
17	R:R:F256	R:R:H177	40.6658	4.53	Yes	No	0	7	2
18	R:R:C254	R:R:F256	54.4269	2.79	No	Yes	0	9	7
19	R:R:C184	R:R:C254	52.9226	7.28	No	No	0	9	9
20	R:R:C184	R:R:V176	49.747	3.42	No	Yes	7	9	2
21	R:R:D173	R:R:V176	43.7021	4.38	No	Yes	0	3	2
22	R:R:D173	R:R:E175	42.1329	5.2	No	No	0	3	1
23	R:R:E175	R:R:H174	40.5543	9.85	No	No	0	1	2
24	L:L:R22	R:R:H174	37.3926	1.13	No	No	0	0	2
25	L:L:E19	L:L:R22	34.2216	1.16	No	No	0	0	0
26	L:L:E19	L:L:T23	32.5828	1.41	No	No	0	0	0
27	L:L:T23	R:R:D104	30.9485	1.45	No	No	0	0	1
28	R:R:D104	R:R:L102	27.6522	2.71	No	No	0	1	1
29	L:L:Q26	R:R:L102	24.3233	3.99	No	No	0	0	1
30	L:L:Q26	R:R:V71	22.6844	1.43	No	Yes	0	0	4
31	R:R:V71	R:R:Y73	14.0257	8.83	Yes	Yes	8	4	4
32	R:R:F340	R:R:Q337	18.882	4.68	Yes	No	0	7	4
33	R:R:Q337	R:R:Y109	16.2914	2.25	No	Yes	0	4	3
34	R:R:H112	R:R:Y109	10.9894	8.71	No	Yes	10	4	3
35	R:R:Q351	R:R:Y323	22.8376	7.89	No	Yes	1	9	9
36	R:R:M202	R:R:Q351	23.859	5.44	No	No	0	9	9
37	R:R:M202	R:R:N198	24.4812	5.61	No	Yes	0	9	8
38	R:R:N198	R:R:T158	56.8596	4.39	Yes	No	0	8	8
39	R:R:T158	R:R:W201	57.2032	3.64	No	Yes	0	8	9
40	R:R:N154	R:R:W201	87.2	13.56	No	Yes	0	8	9
41	R:R:N154	R:R:W153	84.6279	4.52	No	Yes	0	8	6
42	R:R:F135	R:R:W153	41.1904	11.02	No	Yes	4	5	6
43	R:R:F135	R:R:I160	39.2544	3.77	No	Yes	4	5	7
44	R:R:I160	R:R:L131	31.0507	5.71	Yes	No	4	7	9
45	R:R:L131	R:R:S356	29.1332	6.01	No	No	0	9	8
46	R:R:A130	R:R:S356	54.7379	3.42	No	No	0	6	8
47	R:R:A130	R:R:F353	50.5827	2.77	No	Yes	0	6	5
48	R:R:F350	R:R:F353	33.8688	3.22	Yes	Yes	0	6	5
49	R:R:F138	R:R:W153	65.7226	4.01	Yes	Yes	0	7	6
50	R:R:C360	R:R:F138	38.1633	4.19	Yes	Yes	0	7	7
51	R:R:A134	R:R:C360	32.1046	3.61	No	Yes	0	8	7
52	R:R:A134	R:R:S356	29.9132	3.42	No	No	0	8	8
53	R:R:F138	R:R:V366	15.335	2.62	Yes	No	0	7	8
54	R:R:L141	R:R:V366	13.1622	1.49	Yes	No	0	6	8
55	R:R:F138	R:R:N149	13.2272	2.42	Yes	No	0	7	7
56	R:R:I151	R:R:W201	29.5557	4.7	Yes	Yes	1	8	9
57	R:R:I151	R:R:L147	13.1715	7.14	Yes	Yes	1	8	6
58	L:L:I7	R:R:F199	22.0948	3.77	Yes	Yes	1	0	8
59	R:R:I272	R:R:V196	82.729	3.07	No	Yes	1	7	6
60	R:R:F200	R:R:V196	12.749	3.93	Yes	Yes	1	5	6
61	R:R:F200	R:R:I234	11.8761	3.77	Yes	Yes	1	5	3
62	R:R:I230	R:R:I234	19.0956	4.42	No	Yes	0	4	3
63	R:R:I230	R:R:V204	16.6442	3.07	No	Yes	0	4	7
64	R:R:V196	R:R:Y268	50.202	3.79	Yes	Yes	1	6	8
65	R:R:P235	R:R:V196	64.4227	3.53	Yes	Yes	1	9	6
66	R:R:I234	R:R:P235	11.3097	3.39	Yes	Yes	1	3	9
67	R:R:E205	R:R:I151	17.5403	5.47	Yes	Yes	1	9	8
68	R:R:P235	R:R:Y193	36.3341	4.17	Yes	Yes	1	9	8
69	R:R:F194	R:R:Y193	30.8139	5.16	No	Yes	0	6	8
70	R:R:F194	R:R:L161	29.1007	13.4	No	No	0	6	5
71	R:R:L161	R:R:T157	27.55	2.95	No	No	0	5	3
72	R:R:I239	R:R:V196	35.2384	3.07	No	Yes	0	7	6
73	R:R:I239	R:R:Y193	35.0202	9.67	No	Yes	0	7	8
74	R:R:N198	R:R:R162	37.1744	9.64	Yes	No	0	8	8
75	R:R:F191	R:R:V195	37.4669	5.24	Yes	No	0	6	6
76	R:R:H177	R:R:Q253	37.4809	14.84	No	No	0	2	4
77	R:R:E259	R:R:Q253	34.2588	6.37	Yes	No	0	3	4
78	R:R:D262	R:R:E259	27.7032	6.5	No	Yes	0	4	3
79	R:R:D262	R:R:E250	26.0411	14.29	No	No	0	4	6
80	R:R:E250	R:R:K246	13.9236	8.1	No	No	3	6	5
81	R:R:K246	R:R:W255	12.41	8.12	No	Yes	3	5	9
82	R:R:P235	R:R:T197	19.3602	5.25	Yes	No	1	9	8
83	R:R:W232	R:R:Y193	37.9033	3.86	No	Yes	1	9	8
84	R:R:T197	R:R:W232	18.8774	4.85	No	No	1	8	9
85	R:R:F199	R:R:L276	32.0256	7.31	Yes	No	1	8	7
86	R:R:L276	R:R:M324	100	2.83	No	Yes	1	7	5
87	R:R:I321	R:R:M324	90.2363	4.37	Yes	Yes	1	6	5
88	R:R:I321	R:R:L319	67.6865	2.85	Yes	No	0	6	8
89	R:R:L319	R:R:N279	37.3973	4.12	No	No	0	8	9
90	R:R:F203	R:R:N279	34.0359	7.25	Yes	No	0	7	9
91	R:R:F203	R:R:I278	23.9519	5.02	Yes	No	0	7	5
92	R:R:E205	R:R:L318	11.0729	10.6	Yes	No	0	9	8
93	R:R:G206	R:R:L319	27.2297	1.71	No	No	0	8	8
94	R:R:G206	R:R:L209	23.859	1.71	No	No	0	8	8
95	R:R:I213	R:R:L209	17.0621	4.28	No	No	5	7	8
96	R:R:F282	R:R:I278	17.2106	5.02	No	No	0	7	5
97	R:R:F282	R:R:H210	13.84	9.05	No	No	0	7	8
98	R:R:H210	R:R:V214	10.3858	15.22	No	No	0	8	6
99	R:R:I213	R:R:I289	13.7472	4.42	No	No	5	7	7
100	R:R:L147	R:R:R223	10.8037	2.43	Yes	Yes	0	6	5
101	R:R:E250	R:R:V264	10.4415	8.56	No	Yes	3	6	4
102	R:R:Q269	R:R:Y266	12.4193	2.25	Yes	No	0	6	6
103	R:R:I321	R:R:L316	13.7564	4.28	Yes	No	0	6	7
104	R:R:F350	R:R:F354	17.0064	2.14	Yes	No	0	6	6
105	R:R:F354	R:R:F358	12.7675	4.29	No	No	0	6	7
106	R:R:F199	R:R:Y323	18.947	10.32	Yes	Yes	1	8	9
107	R:R:F191	R:R:W166	29.5696	6.01	Yes	Yes	0	6	7
108	L:L:F11	R:R:N192	25.4376	8.46	Yes	No	1	0	8
109	R:R:T157	R:R:W153	26.7422	7.28	No	Yes	0	3	6
110	R:R:R162	R:R:V195	36.9469	13.08	No	No	0	8	6
111	R:R:W201	R:R:W232	55.1975	12.18	Yes	No	1	9	9
112	R:R:I272	R:R:L276	71.1639	2.85	No	No	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:L5	R:R:F327	4.87	0	No	No	0	5	0	1
L:L:S6	R:R:N344	8.94	0	No	No	0	8	0	1
L:L:I7	R:R:F199	3.77	1	Yes	Yes	0	8	0	1
L:L:I7	R:R:Q269	6.86	1	Yes	Yes	0	6	0	1
L:L:I7	R:R:Y323	3.63	1	Yes	Yes	0	9	0	1
L:L:D8	R:R:Q269	6.53	1	No	Yes	0	6	0	1
L:L:L9	R:R:F340	3.65	6	Yes	Yes	0	7	0	1
L:L:L9	R:R:N344	4.12	6	Yes	No	0	8	0	1
L:L:L9	R:R:S345	3	6	Yes	No	0	6	0	1
L:L:L9	R:R:Q348	3.99	6	Yes	No	0	8	0	1
L:L:T10	R:R:W166	3.64	0	No	Yes	0	7	0	1
L:L:T10	R:R:Q348	2.83	0	No	No	0	8	0	1
L:L:F11	R:R:F191	4.29	1	Yes	Yes	0	6	0	1
L:L:F11	R:R:N192	8.46	1	Yes	No	0	8	0	1
L:L:F11	R:R:F256	10.72	1	Yes	Yes	0	7	0	1
L:L:L13	R:R:I341	2.85	0	No	No	0	6	0	1
L:L:L14	R:R:Q170	6.65	0	No	No	0	6	0	1
L:L:R15	R:R:F256	3.21	1	Yes	Yes	0	7	0	1
L:L:R15	R:R:K258	11.14	1	Yes	No	0	5	0	1
L:L:T16	R:R:Y113	12.48	0	No	No	0	4	0	1
L:L:L18	R:R:H177	5.14	0	No	No	0	2	0	1
L:L:S25	R:R:H174	6.97	0	No	No	0	2	0	1
L:L:Q26	R:R:L102	3.99	0	No	No	0	1	0	1
L:L:R29	R:R:V71	3.92	0	No	Yes	0	4	0	1
L:L:A30	R:R:L102	3.15	0	No	No	0	1	0	1
L:L:N33	R:R:N69	6.81	8	Yes	No	0	3	0	1
L:L:N33	R:R:V71	2.96	8	Yes	Yes	0	4	0	1
L:L:N33	R:R:Y73	3.49	8	Yes	Yes	0	4	0	1
R:R:F68	R:R:P65	5.78	0	Yes	No	6	8	1	2
R:R:F68	R:R:N69	12.08	0	Yes	No	6	3	1	1
R:R:F68	R:R:Y73	5.16	0	Yes	Yes	6	4	1	1
R:R:V71	R:R:Y73	8.83	8	Yes	Yes	4	4	1	1
R:R:D110	R:R:R107	4.76	0	No	No	3	1	2	1
R:R:H124	R:R:N120	7.65	2	Yes	No	6	7	2	2
R:R:N120	R:R:W166	9.04	2	No	Yes	7	7	2	1
R:R:W166	R:R:Y121	8.68	2	Yes	Yes	7	5	1	2
R:R:F167	R:R:Y121	4.13	2	No	Yes	6	5	2	2
R:R:Q170	R:R:Y121	11.27	2	No	Yes	6	5	1	2
R:R:H124	R:R:W166	27.51	2	Yes	Yes	6	7	2	1
R:R:F191	R:R:M165	3.73	0	Yes	No	6	5	1	2
R:R:F167	R:R:W166	10.02	2	No	Yes	6	7	2	1
R:R:Q170	R:R:W166	21.9	2	No	Yes	6	7	1	1
R:R:F191	R:R:W166	6.01	0	Yes	Yes	6	7	1	1
R:R:L169	R:R:T188	2.95	0	No	No	6	7	2	2
R:R:F191	R:R:L169	3.65	0	Yes	No	6	6	1	2
R:R:E175	R:R:H174	9.85	0	No	No	1	2	2	1
R:R:H177	R:R:Q253	14.84	0	No	No	2	4	1	2
R:R:F256	R:R:H177	4.53	1	Yes	No	7	2	1	1
R:R:F256	R:R:T188	5.19	1	Yes	No	7	7	1	2
R:R:F191	R:R:V195	5.24	0	Yes	No	6	6	1	2
R:R:N192	R:R:W242	6.78	1	No	Yes	8	8	1	2
R:R:N192	R:R:Y268	5.81	1	No	Yes	8	8	1	2
R:R:F199	R:R:I272	13.82	1	Yes	No	8	7	1	2
R:R:F199	R:R:L276	7.31	1	Yes	No	8	7	1	2
R:R:F199	R:R:Y323	10.32	1	Yes	Yes	8	9	1	1
R:R:D265	R:R:W242	6.7	1	No	Yes	6	8	2	2
R:R:W242	R:R:Y268	13.5	1	Yes	Yes	8	8	2	2
R:R:L263	R:R:Y266	3.52	0	No	No	3	6	2	1
R:R:D265	R:R:Y268	11.49	1	No	Yes	6	8	2	2
R:R:D265	R:R:Q269	7.83	1	No	Yes	6	6	2	1
R:R:Q269	R:R:Y268	12.4	1	Yes	Yes	6	8	1	2
R:R:I272	R:R:L276	2.85	1	No	No	7	7	2	2
R:R:F327	R:R:I273	8.79	0	No	No	5	4	1	2
R:R:T322	R:R:Y323	3.75	1	No	Yes	8	9	2	1
R:R:Q351	R:R:T322	4.25	1	No	No	9	8	2	2
R:R:Q348	R:R:Y323	3.38	0	No	Yes	8	9	1	1
R:R:Q351	R:R:Y323	7.89	1	No	Yes	9	9	2	1
R:R:F326	R:R:N329	9.67	6	No	Yes	8	5	2	2
R:R:F326	R:R:F340	7.5	6	No	Yes	8	7	2	1
R:R:F327	R:R:V328	5.24	0	No	No	5	5	1	2
R:R:F340	R:R:N329	9.67	6	Yes	Yes	7	5	1	2
R:R:F340	R:R:Q337	4.68	6	Yes	No	7	4	1	2
R:R:F340	R:R:I341	3.77	6	Yes	No	7	6	1	1
R:R:F340	R:R:N344	7.25	6	Yes	No	7	8	1	1
R:R:C254	R:R:F256	2.79	0	No	Yes	9	7	2	1
R:R:P100	R:R:Y73	2.78	0	No	Yes	1	4	2	1
R:R:D104	R:R:L102	2.71	0	No	No	1	1	1	1
L:L:S4	R:R:F340	2.64	0	No	Yes	0	7	0	1
L:L:L20	R:R:R107	2.43	0	No	No	0	1	0	1
R:R:I341	R:R:Y113	2.42	0	No	No	6	4	1	1
L:L:L17	R:R:Y113	2.34	0	No	No	0	4	0	1
R:R:Q269	R:R:Y266	2.25	1	Yes	No	6	6	1	1
L:L:F37	R:R:F68	2.14	0	No	Yes	0	6	0	1
R:R:A116	R:R:S345	1.71	0	No	No	7	6	2	1
R:R:G270	R:R:Q269	1.64	0	No	Yes	5	6	2	1
L:L:T23	R:R:D104	1.45	0	No	No	0	1	0	1
L:L:Q26	R:R:V71	1.43	0	No	Yes	0	4	0	1
L:L:P3	R:R:Y266	1.39	0	No	No	0	6	0	1
R:R:D104	R:R:K105	1.38	0	No	No	1	3	1	2
L:L:R22	R:R:E178	1.16	0	No	No	0	3	0	1
L:L:R22	R:R:H174	1.13	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TS0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	300
Number of Links	342
Number of Hubs	50
Number of Links mediated by Hubs	188
Number of Communities	11
Number of Nodes involved in Communities	83
Number of Links involved in Communities	113

Path Summary
Number Of Nodes in MetaPath	113
Number Of Links MetaPath	112
Number of Shortest Paths	65076
Length Of Smallest Path	3
Average Path Length	14.968
Length of Longest Path	38
Minimum Path Strength	1.145
Average Path Strength	5.56346
Maximum Path Strength	24.705
Minimum Path Correlation	0.7
Average Path Correlation	0.952085
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	65.219
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6545
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • cellular process • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of biological process • long-term synaptic potentiation • synaptic signaling • regulation of biological quality • positive regulation of cellular process • regulation of synaptic plasticity • trans-synaptic signaling • regulation of signaling • cell-cell signaling • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse • distal axon • cell junction • neuron projection terminus • molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • G protein-coupled receptor binding • hormone receptor binding • neuropeptide receptor binding • deacetylase activity • enzyme regulator activity • protein lysine deacetylase activity • catalytic activity, acting on a protein • deacylase activity • enzyme inhibitor activity • histone deacetylase activity • molecular function inhibitor activity • histone deacetylase inhibitor activity • histone deacetylase regulator activity • catalytic activity • corticotropin-releasing hormone receptor 1 binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • regulation of growth • regulation of cellular component organization • growth • positive regulation of biological process • positive regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • positive regulation of growth • cellular component organization or biogenesis • positive regulation of cellular process • multicellular organismal process • response to stress • multicellular organismal response to stress • response to pain • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of biological process • negative regulation of appetite • regulation of response to food • regulation of response to stimulus • response to food • response to chemical • regulation of biological quality • regulation of appetite • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • aerobic respiration • cellular respiration • energy derivation by oxidation of organic compounds • metabolic process • generation of precursor metabolites and energy • interleukin-6 production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-6 production • regulation of interleukin-6 production • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of defense response • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • regulation of response to stress • behavioral fear response • defense response • positive regulation of behavioral fear response • behavior • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of DNA replication • regulation of primary metabolic process • nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • DNA metabolic process • nucleic acid metabolic process • DNA replication • positive regulation of DNA metabolic process • regulation of DNA metabolic process • regulation of DNA replication • regulation of localization • regulation of hormone secretion • negative regulation of signaling • transport • negative regulation of transport • hormone secretion • negative regulation of cell communication • localization • negative regulation of secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to endogenous stimulus • response to glucocorticoid • drinking behavior • feeding behavior • positive regulation of protein metabolic process • positive regulation of translation • post-transcriptional regulation of gene expression • protein metabolic process • regulation of protein metabolic process • translation • regulation of translation • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • startle response • nervous system process • neuromuscular process • response to external stimulus • response to auditory stimulus • response to mechanical stimulus • response to abiotic stimulus • positive regulation of cell communication • nitrogen compound transport • regulation of system process • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • positive regulation of peptide hormone secretion • endocrine hormone secretion • regulation of endocrine process • regulation of peptide secretion • positive regulation of secretion by cell • regulation of corticotropin secretion • peptide secretion • positive regulation of hormone secretion • positive regulation of secretion • amide transport • positive regulation of peptide secretion • corticotropin secretion • regulation of peptide transport • peptide transport • endocrine process • positive regulation of transport • peptide hormone secretion • positive regulation of signaling • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • sensory perception • sensory perception of sound • sensory perception of mechanical stimulus • regulation of vascular permeability • positive regulation of vascular permeability • biological process involved in intraspecies interaction between organisms • social behavior • learning • learning or memory • cognition • associative learning • trans-synaptic signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • response to oxidative stress • negative regulation of feeding behavior • negative regulation of behavior • regulation of feeding behavior • negative regulation of multicellular organismal process • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • positive regulation of DNA-templated transcription • RNA metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • system development • negative regulation of cell size • regulation of cellular component size • regulation of cell size • heart process • regulation of heart contraction • positive regulation of blood circulation • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of heart contraction • regulation of blood circulation • regulation of striated muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • heart contraction • response to estradiol • response to oxygen-containing compound • regulation of blood pressure • negative regulation of blood pressure • cell body • perikaryon • neuronal cell body • main axon • varicosity • extracellular region • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to oxygen levels • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13324
Sequence	>7TS0_nogp_Chain_R C P E Y F N G V K Y C E P I L D D K Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L R S I R C L R N V I H W N L I T T F I L R N V M W F L L Q L V D H E V H E S N E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M T Y S T E R L R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E N E Q C W F G K E P G D L V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V N P G E D D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R S A V R K R W H R W Q D H H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TRY	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-G11)/β1/γ2	3.7	2022-11-09	10.1038/s41467-022-33851-3
	7TRY (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		3.7	2022-11-09	10.1038/s41467-022-33851-3
	7TS0	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1L-Go)/β1/γ2	2.8	2022-11-09	10.1038/s41467-022-33851-3
	7TS0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2022-11-09	10.1038/s41467-022-33851-3
	6PB1	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	2.8	2020-02-12	10.1016/j.molcel.2020.01.013
	6PB1 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₂	Homo sapiens	Urocortin	-		2.8	2020-02-12	10.1016/j.molcel.2020.01.013

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