psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L131	R:R:Q134	6.65	No	No	0	2	1
2	L:L:K20	R:R:D132	6.91	No	No	0	0	1
3	R:R:Q135	R:R:Y139	7.89	No	Yes	0	3	4
4	L:L:Y13	R:R:Q135	19.16	No	No	0	0	3
5	L:L:Y13	R:R:T136	7.49	No	No	0	0	2
6	R:R:F138	R:R:V142	3.93	No	No	0	5	5
7	R:R:E367	R:R:F138	5.83	No	No	0	3	5
8	L:L:F6	R:R:Y139	6.19	Yes	Yes	0	0	4
9	L:L:S9	R:R:Y139	5.09	No	Yes	0	0	4
10	L:L:Y10	R:R:Y139	9.93	No	Yes	0	0	4
11	L:L:F6	R:R:V142	7.87	Yes	No	0	0	5
12	R:R:K143	R:R:Y146	4.78	No	Yes	0	5	8
13	R:R:D196	R:R:K143	5.53	No	No	0	7	5
14	R:R:L374	R:R:Y146	4.69	No	Yes	3	7	8
15	L:L:F6	R:R:Y146	6.19	Yes	Yes	3	0	8
16	R:R:R188	R:R:Y150	8.23	Yes	No	0	8	8
17	R:R:V192	R:R:Y150	7.57	No	No	0	7	8
18	R:R:S378	R:R:Y150	10.17	No	No	0	9	8
19	R:R:F382	R:R:L152	15.83	No	No	0	6	5
20	R:R:G381	R:R:S153	3.71	No	No	0	9	9
21	R:R:A189	R:R:L154	4.73	No	Yes	0	7	6
22	R:R:F382	R:R:T156	6.49	No	No	0	6	6
23	R:R:F182	R:R:L157	8.53	Yes	Yes	0	8	9
24	R:R:F185	R:R:L157	3.65	Yes	Yes	0	8	9
25	R:R:I186	R:R:L158	5.71	No	No	0	6	3
26	R:R:F390	R:R:V159	3.93	No	No	0	9	5
27	R:R:A160	R:R:C389	3.61	No	No	0	9	9
28	R:R:F182	R:R:T161	3.89	Yes	No	0	8	6
29	R:R:C389	R:R:I163	4.91	No	No	0	9	8
30	R:R:L164	R:R:M179	4.24	No	No	0	7	6
31	R:R:F167	R:R:L170	6.09	Yes	No	0	6	9
32	R:R:F167	R:R:L399	4.87	Yes	No	0	6	5
33	R:R:F167	R:R:K402	3.72	Yes	No	0	6	5
34	R:R:E394	R:R:K169	6.75	No	No	0	9	7
35	R:R:E398	R:R:K169	9.45	No	No	0	7	7
36	R:R:E394	R:R:L170	6.63	No	No	0	9	9
37	R:R:L170	R:R:V395	7.45	No	No	0	9	9
38	R:R:H171	R:R:Y176	8.71	No	No	0	8	6
39	R:R:T173	R:R:Y239	6.24	No	Yes	0	7	8
40	R:R:E251	R:R:T173	11.29	No	No	0	6	7
41	R:R:R252	R:R:T173	3.88	No	No	0	5	7
42	R:R:N175	R:R:R174	12.05	No	No	4	9	9
43	R:R:H178	R:R:R174	4.51	No	No	4	9	9
44	R:R:H178	R:R:N175	3.83	No	No	4	9	9
45	R:R:F255	R:R:Y176	4.13	No	No	0	6	6
46	R:R:E236	R:R:I177	4.1	No	No	0	9	9
47	R:R:I177	R:R:Y239	8.46	No	Yes	0	9	8
48	R:R:H180	R:R:W232	12.7	No	Yes	0	9	9
49	R:R:H180	R:R:I259	6.63	No	No	0	9	4
50	R:R:F182	R:R:L181	3.65	Yes	Yes	0	8	9
51	R:R:F185	R:R:L181	8.53	Yes	Yes	0	8	9
52	R:R:L181	R:R:L233	4.15	Yes	No	0	9	9
53	R:R:E236	R:R:L181	15.9	No	Yes	0	9	9
54	R:R:N229	R:R:S184	4.47	No	No	0	8	9
55	R:R:F185	R:R:N229	8.46	Yes	No	0	8	8
56	R:R:N229	R:R:R188	8.44	No	Yes	0	8	8
57	R:R:F230	R:R:R188	3.21	Yes	Yes	0	8	8
58	L:L:D3	R:R:R188	4.76	Yes	Yes	0	0	8
59	R:R:A191	R:R:F221	4.16	No	No	5	6	4
60	R:R:A191	R:R:C225	3.61	No	No	5	6	6
61	R:R:F222	R:R:V192	3.93	Yes	No	0	7	7
62	R:R:K195	R:R:M219	8.64	No	No	0	7	5
63	R:R:F222	R:R:K195	9.93	Yes	No	0	7	7
64	L:L:Y10	R:R:L199	4.69	No	No	0	0	7
65	R:R:D201	R:R:F200	4.78	No	No	0	4	4
66	R:R:C215	R:R:C285	7.28	No	No	0	9	9
67	R:R:D282	R:R:K216	8.3	No	No	6	6	8
68	R:R:K216	R:R:W286	27.85	No	Yes	6	8	9
69	R:R:M219	R:R:Q223	5.44	No	Yes	0	5	7
70	R:R:C225	R:R:F221	8.38	No	No	5	6	4
71	R:R:F222	R:R:Q223	8.2	Yes	Yes	0	7	7
72	L:L:D3	R:R:F222	4.78	Yes	Yes	0	0	7
73	R:R:Q223	R:R:W273	5.48	Yes	No	7	7	8
74	R:R:I297	R:R:Q223	5.49	No	Yes	7	7	7
75	L:L:H1	R:R:Q223	8.65	Yes	Yes	0	0	7
76	R:R:W263	R:R:Y224	7.72	No	Yes	0	8	9
77	R:R:S267	R:R:Y224	3.82	No	Yes	0	3	9
78	R:R:T270	R:R:Y224	8.74	No	Yes	0	6	9
79	R:R:F230	R:R:V226	3.93	Yes	No	0	8	5
80	L:L:H1	R:R:V226	12.45	Yes	No	0	0	5
81	R:R:F231	R:R:M227	3.73	Yes	No	8	5	5
82	R:R:M227	R:R:P266	6.71	No	Yes	8	5	9
83	R:R:I301	R:R:M227	4.37	No	No	0	7	5
84	R:R:A228	R:R:P266	3.74	No	Yes	0	8	9
85	R:R:F230	R:R:I301	10.05	Yes	No	0	8	7
86	R:R:F230	R:R:Y354	10.32	Yes	Yes	0	8	8
87	R:R:F231	R:R:P266	10.11	Yes	Yes	8	5	9
88	R:R:V235	R:R:W232	6.13	No	Yes	0	7	9
89	R:R:G262	R:R:W232	8.44	No	Yes	0	9	9
90	R:R:W232	R:R:W263	15.93	Yes	No	0	9	8
91	R:R:L234	R:R:S304	9.01	No	No	0	8	7
92	R:R:E236	R:R:L349	5.3	No	No	0	9	9
93	R:R:G237	R:R:N308	3.39	No	No	2	9	9
94	R:R:F350	R:R:G237	6.02	Yes	No	2	9	9
95	R:R:L243	R:R:Y239	12.89	No	Yes	0	7	8
96	R:R:Y239	R:R:Y258	4.96	Yes	No	0	8	7
97	R:R:L240	R:R:L244	4.15	No	No	0	9	8
98	R:R:I315	R:R:L240	7.14	No	No	0	9	9
99	R:R:F350	R:R:L240	6.09	Yes	No	0	9	9
100	R:R:A245	R:R:Y241	8.01	No	Yes	0	7	8
101	R:R:L311	R:R:Y241	5.86	No	Yes	0	8	8
102	R:R:C314	R:R:Y241	4.03	No	Yes	0	8	8
103	R:R:T242	R:R:Y258	4.99	No	No	0	7	7
104	R:R:I318	R:R:L244	4.28	No	No	0	8	8
105	R:R:F248	R:R:S247	9.25	No	No	0	6	7
106	R:R:F249	R:R:K253	3.72	No	No	0	5	4
107	R:R:F249	R:R:Y254	15.47	No	No	0	5	4
108	R:R:Y254	R:R:Y258	9.93	No	No	0	4	7
109	R:R:F255	R:R:I259	7.54	No	No	0	6	4
110	R:R:P266	R:R:V265	3.53	Yes	No	0	9	5
111	R:R:F269	R:R:P300	13	No	No	0	6	9
112	R:R:R277	R:R:W273	11	No	No	0	8	8
113	R:R:I297	R:R:W273	18.79	No	No	7	7	8
114	R:R:T274	R:R:W286	4.85	No	Yes	0	6	9
115	R:R:H279	R:R:I275	3.98	No	No	0	1	4
116	R:R:R277	R:R:W286	23.99	No	Yes	0	8	9
117	R:R:L293	R:R:R277	7.29	No	No	0	4	8
118	R:R:I278	R:R:W286	4.7	No	Yes	0	3	9
119	R:R:E281	R:R:F280	7	No	No	0	6	3
120	R:R:E281	R:R:Y283	7.86	No	No	0	6	3
121	R:R:D282	R:R:W286	5.58	No	Yes	6	6	9
122	R:R:N290	R:R:Y283	5.81	No	No	0	3	3
123	L:L:T7	R:R:D287	5.78	No	No	0	0	5
124	L:L:S11	R:R:D287	7.36	No	No	0	0	5
125	L:L:D8	R:R:T288	5.78	No	No	0	0	4
126	R:R:I289	R:R:W294	10.57	No	No	0	8	7
127	L:L:D8	R:R:I289	7	No	No	0	0	8
128	R:R:L293	R:R:N290	4.12	No	No	0	4	3
129	R:R:I297	R:R:W294	3.52	No	No	0	7	7
130	R:R:K298	R:R:W294	6.96	No	No	0	7	7
131	R:R:K298	R:R:L302	7.05	No	No	0	7	4
132	R:R:G299	R:R:P300	4.06	No	No	0	4	9
133	R:R:I305	R:R:Y354	4.84	No	Yes	1	7	8
134	R:R:F350	R:R:N308	10.87	Yes	No	2	9	9
135	R:R:F309	R:R:I313	8.79	No	No	0	5	5
136	R:R:F309	R:R:I355	12.56	No	Yes	0	5	5
137	R:R:F312	R:R:I316	10.05	Yes	No	0	9	7
138	R:R:F312	R:R:L346	6.09	Yes	No	2	9	9
139	R:R:F312	R:R:I347	5.02	Yes	Yes	2	9	8
140	R:R:F312	R:R:F350	3.22	Yes	Yes	2	9	9
141	R:R:F312	R:R:V352	13.11	Yes	No	2	9	6
142	R:R:I316	R:R:T343	6.08	No	No	0	7	9
143	R:R:Q321	R:R:R317	8.18	No	No	0	7	7
144	R:R:L320	R:R:R324	3.64	No	No	0	5	6
145	R:R:L323	R:R:R338	6.07	No	No	0	8	8
146	R:R:P325	R:R:P326	5.84	No	No	0	6	6
147	R:R:R338	R:R:R341	5.33	No	No	0	8	8
148	R:R:L345	R:R:L387	5.54	No	No	0	8	8
149	R:R:F350	R:R:L346	8.53	Yes	No	2	9	9
150	R:R:I347	R:R:P348	3.39	Yes	No	0	8	9
151	R:R:I347	R:R:V352	10.75	Yes	No	2	8	6
152	R:R:P348	R:R:V383	3.53	No	No	0	9	5
153	R:R:F350	R:R:L349	7.31	Yes	No	0	9	9
154	R:R:L349	R:R:Y388	15.24	No	No	0	9	8
155	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
156	R:R:H353	R:R:Y354	20.69	Yes	Yes	1	8	8
157	R:R:H353	R:R:V376	6.92	Yes	No	0	8	5
158	R:R:H353	R:R:Q380	9.89	Yes	No	1	8	9
159	R:R:E373	R:R:Y354	7.86	Yes	Yes	1	7	8
160	R:R:Q380	R:R:Y354	7.89	No	Yes	1	9	8
161	R:R:F357	R:R:F360	7.5	Yes	Yes	1	6	5
162	R:R:F357	R:R:K369	6.2	Yes	Yes	1	6	8
163	R:R:F357	R:R:F372	5.36	Yes	Yes	1	6	4
164	R:R:E373	R:R:F357	5.83	Yes	Yes	1	7	6
165	R:R:F360	R:R:P361	7.22	Yes	No	0	5	8
166	R:R:F360	R:R:F364	5.36	Yes	No	1	5	3
167	R:R:F360	R:R:K365	6.2	Yes	Yes	1	5	2
168	R:R:F360	R:R:K369	4.96	Yes	Yes	1	5	8
169	R:R:D362	R:R:K369	8.3	No	Yes	0	4	8
170	L:L:I5	R:R:D362	12.59	No	No	0	0	4
171	R:R:F364	R:R:K365	7.44	No	Yes	1	3	2
172	R:R:K365	R:R:V368	6.07	Yes	No	0	2	4
173	L:L:S2	R:R:K369	4.59	No	Yes	0	0	8
174	L:L:F6	R:R:M370	6.22	Yes	No	0	0	6
175	R:R:E373	R:R:F372	4.66	Yes	Yes	1	7	4
176	R:R:F372	R:R:V376	6.55	Yes	No	0	4	5
177	L:L:S2	R:R:E373	7.19	No	Yes	0	0	7
178	L:L:D3	R:R:L374	5.43	Yes	No	0	0	7
179	L:L:F6	R:R:L374	3.65	Yes	No	3	0	7
180	R:R:G377	R:R:Q380	3.29	No	No	0	6	9
181	R:R:F382	R:R:I386	10.05	No	No	0	6	5
182	R:R:N392	R:R:V395	4.43	No	No	0	9	9
183	R:R:K402	R:R:R405	3.71	No	No	0	5	7
184	L:L:D3	L:L:H1	5.04	Yes	Yes	0	0	0
185	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
186	L:L:G4	L:L:T7	3.64	No	No	0	0	0
187	L:L:D8	L:L:R12	9.53	No	No	0	0	0
188	L:L:R14	L:L:Y10	10.29	No	No	0	0	0
189	L:L:M17	L:L:Y13	13.17	No	No	0	0	0
190	R:R:C225	R:R:L187	3.17	No	No	0	6	6
191	R:R:T274	R:R:V220	3.17	No	No	0	6	5
192	R:R:A385	R:R:L157	3.15	No	Yes	0	8	9
193	R:R:M179	R:R:S165	3.07	No	No	0	6	3
194	R:R:I261	R:R:V235	3.07	No	No	0	6	7
195	R:R:I148	R:R:T144	3.04	No	No	0	5	4
196	R:R:I183	R:R:T161	3.04	No	No	0	3	6
197	R:R:F379	R:R:G149	3.01	No	No	0	7	8
198	R:R:F185	R:R:G381	3.01	Yes	No	0	8	9
199	R:R:L319	R:R:S342	3	No	No	0	8	9
200	R:R:L234	R:R:V307	2.98	No	No	0	8	6
201	R:R:L387	R:R:V383	2.98	No	No	0	8	5
202	R:R:L339	R:R:T343	2.95	No	No	0	8	9
203	R:R:I305	R:R:I355	2.94	No	Yes	1	7	5
204	R:R:F231	R:R:P300	2.89	Yes	No	0	5	9
205	R:R:P325	R:R:R324	2.88	No	No	0	6	6
206	R:R:E133	R:R:S130	2.87	No	No	0	2	1
207	R:R:I186	R:R:L154	2.85	No	Yes	0	6	6
208	R:R:I186	R:R:L157	2.85	No	Yes	0	6	9
209	R:R:I386	R:R:L391	2.85	No	No	0	5	6
210	R:R:G257	R:R:W256	2.81	No	No	0	2	3
211	R:R:P266	R:R:Y224	2.78	Yes	Yes	0	9	9
212	R:R:A160	R:R:F182	2.77	No	Yes	0	9	8
213	R:R:L238	R:R:L311	2.77	No	No	0	6	8
214	L:L:L23	L:L:L27	2.77	No	No	0	0	0
215	R:R:L391	R:R:Q396	2.66	No	No	0	6	7
216	R:R:H279	R:R:I278	2.65	No	No	0	1	3
217	R:R:F138	R:R:V371	2.62	No	No	0	5	5
218	R:R:F182	R:R:V384	2.62	Yes	No	0	8	9
219	R:R:F185	R:R:V384	2.62	Yes	No	0	8	9
220	R:R:F167	R:R:I163	2.51	Yes	No	0	6	8
221	R:R:F390	R:R:I163	2.51	No	No	0	9	8
222	R:R:F221	R:R:I194	2.51	No	No	0	4	5
223	R:R:T147	R:R:Y146	2.5	No	Yes	0	7	8
224	R:R:F357	R:R:M356	2.49	Yes	No	1	6	6
225	R:R:F372	R:R:M356	2.49	Yes	No	1	4	6
226	R:R:F193	R:R:L154	2.44	No	Yes	0	7	6
227	R:R:F182	R:R:L164	2.44	Yes	No	0	8	7
228	R:R:F231	R:R:L234	2.44	Yes	No	0	5	8
229	R:R:L345	R:R:R341	2.43	No	No	0	8	8
230	R:R:I315	R:R:Y241	2.42	No	Yes	0	9	8
231	R:R:K298	R:R:W295	2.32	No	No	0	7	6
232	R:R:L187	R:R:W263	2.28	No	No	0	6	8
233	R:R:H178	R:R:Y388	2.18	No	No	0	9	8
234	R:R:G149	R:R:S378	1.86	No	No	0	8	9
235	R:R:G264	R:R:S267	1.86	No	No	0	7	3
236	R:R:G140	R:R:K143	1.74	No	No	0	3	5
237	R:R:C215	R:R:S212	1.72	No	No	0	9	3
238	R:R:G151	R:R:L154	1.71	No	Yes	0	6	6
239	R:R:G257	R:R:L260	1.71	No	No	0	2	3
240	R:R:A245	R:R:V246	1.7	No	No	0	7	4
241	R:R:A385	R:R:T156	1.68	No	No	0	8	6
242	R:R:D282	R:R:G284	1.68	No	No	0	6	4
243	R:R:K365	R:R:P366	1.67	Yes	No	0	2	5
244	R:R:S291	R:R:S292	1.63	No	No	0	5	3
245	R:R:A218	R:R:I194	1.62	No	No	0	5	5
246	R:R:A276	R:R:I296	1.62	No	No	0	4	8
247	R:R:A358	R:R:I305	1.62	No	No	1	6	7
248	R:R:A358	R:R:I355	1.62	No	Yes	1	6	5
249	R:R:T303	R:R:V307	1.59	No	No	0	3	6
250	R:R:A129	R:R:L131	1.58	No	No	0	2	2
251	R:R:A276	R:R:L293	1.58	No	No	0	4	4
252	R:R:C172	R:R:N175	1.57	No	No	0	8	9
253	R:R:I296	R:R:V272	1.54	No	No	0	8	4
254	R:R:M137	R:R:S141	1.53	No	No	0	2	4
255	L:L:K15	L:L:S11	1.53	No	No	0	0	0
256	R:R:I318	R:R:K322	1.45	No	No	0	8	9
257	R:R:P335	R:R:R338	1.44	No	No	0	7	8
258	L:L:K21	L:L:M17	1.44	No	No	0	0	0
259	R:R:I355	R:R:L306	1.43	Yes	No	0	5	3
260	R:R:I316	R:R:L319	1.43	No	No	0	7	8
261	R:R:I347	R:R:L344	1.43	Yes	No	0	8	7
262	R:R:L320	R:R:L339	1.38	No	No	0	5	8
263	R:R:F379	R:R:V375	1.31	No	No	0	7	5
264	R:R:E398	R:R:R401	1.16	No	No	0	7	7
265	R:R:H171	R:R:R168	1.13	No	No	0	8	7
266	R:R:R404	R:R:W403	1	No	No	0	3	6
267	R:R:W403	R:R:W406	0.94	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y139	7.275	4	0	4
2	R:R:Y146	4.54	4	3	8
3	R:R:L154	2.9325	4	0	6
4	R:R:L157	4.545	4	0	9
5	R:R:F167	4.2975	4	0	6
6	R:R:L181	8.0575	4	0	9
7	R:R:F182	3.98333	6	0	8
8	R:R:F185	5.254	5	0	8
9	R:R:R188	6.16	4	0	8
10	R:R:F222	6.71	4	0	7
11	R:R:Q223	6.652	5	7	7
12	R:R:Y224	5.765	4	0	9
13	R:R:F230	6.8775	4	0	8
14	R:R:F231	4.7925	4	8	5
15	R:R:W232	10.8	4	0	9
16	R:R:Y239	8.1375	4	0	8
17	R:R:Y241	5.08	4	0	8
18	R:R:P266	5.374	5	8	9
19	R:R:W286	13.394	5	6	9
20	R:R:F312	7.498	5	2	9
21	R:R:I347	5.1475	4	2	8
22	R:R:F350	7.00667	6	2	9
23	R:R:H353	10.17	4	1	8
24	R:R:Y354	10.32	5	1	8
25	R:R:I355	4.6375	4	1	5
26	R:R:F357	5.476	5	1	6
27	R:R:F360	6.248	5	1	5
28	R:R:K365	5.345	4	1	2
29	R:R:K369	6.0125	4	1	8
30	R:R:F372	4.765	4	1	4
31	R:R:E373	6.385	4	1	7
32	L:L:H1	7.33	4	0	0
33	L:L:D3	5.0025	4	0	0
34	L:L:F6	6.024	5	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F6	R:R:Y139	12.4545	6.19	Yes	Yes	0	0	4
2	L:L:F6	R:R:L374	19.3327	3.65	Yes	No	3	0	7
3	L:L:D3	R:R:L374	26.5879	5.43	Yes	No	0	0	7
4	L:L:D3	R:R:R188	63.5787	4.76	Yes	Yes	0	0	8
5	L:L:D3	R:R:F222	24.2023	4.78	Yes	Yes	0	0	7
6	R:R:F185	R:R:L157	29.5559	3.65	Yes	Yes	0	8	9
7	R:R:F185	R:R:N229	99.7859	8.46	Yes	No	0	8	8
8	R:R:N229	R:R:R188	100	8.44	No	Yes	0	8	8
9	R:R:F182	R:R:L157	20.6818	8.53	Yes	Yes	0	8	9
10	R:R:F182	R:R:L181	24.6991	3.65	Yes	Yes	0	8	9
11	R:R:F185	R:R:L181	60.1782	8.53	Yes	Yes	0	8	9
12	R:R:F182	R:R:V384	16.339	2.62	Yes	No	0	8	9
13	R:R:F185	R:R:V384	16.9729	2.62	Yes	No	0	8	9
14	R:R:C389	R:R:I163	35.0679	4.91	No	No	0	9	8
15	R:R:A160	R:R:C389	37.5262	3.61	No	No	0	9	9
16	R:R:A160	R:R:F182	39.976	2.77	No	Yes	0	9	8
17	R:R:F167	R:R:I163	27.6286	2.51	Yes	No	0	6	8
18	R:R:F167	R:R:L170	17.7695	6.09	Yes	No	0	6	9
19	R:R:E394	R:R:L170	10.1589	6.63	No	No	0	9	9
20	R:R:W232	R:R:W263	11.3881	15.93	Yes	No	0	9	8
21	R:R:W263	R:R:Y224	18.8531	7.72	No	Yes	0	8	9
22	R:R:P266	R:R:Y224	22.9303	2.78	Yes	Yes	0	9	9
23	R:R:M227	R:R:P266	25.076	6.71	No	Yes	8	5	9
24	R:R:I301	R:R:M227	34.3398	4.37	No	No	0	7	5
25	R:R:F230	R:R:I301	35.2349	10.05	Yes	No	0	8	7
26	R:R:F230	R:R:R188	49.0728	3.21	Yes	Yes	0	8	8
27	R:R:E236	R:R:L181	51.544	15.9	No	Yes	0	9	9
28	R:R:E236	R:R:I177	12.5187	4.1	No	No	0	9	9
29	R:R:I177	R:R:Y239	11.4095	8.46	No	Yes	0	9	8
30	R:R:E236	R:R:L349	42.1945	5.3	No	No	0	9	9
31	R:R:F222	R:R:Q223	22.4378	8.2	Yes	Yes	0	7	7
32	L:L:H1	R:R:Q223	30.6951	8.65	Yes	Yes	0	0	7
33	L:L:D3	L:L:H1	25.8169	5.04	Yes	Yes	0	0	0
34	R:R:R277	R:R:W286	16.7245	23.99	No	Yes	0	8	9
35	R:R:R277	R:R:W273	32.7594	11	No	No	0	8	8
36	R:R:Q223	R:R:W273	33.7659	5.48	Yes	No	7	7	8
37	R:R:I297	R:R:Q223	15.9921	5.49	No	Yes	7	7	7
38	L:L:H1	R:R:V226	10.3002	12.45	Yes	No	0	0	5
39	R:R:F230	R:R:Y354	31.6031	10.32	Yes	Yes	0	8	8
40	R:R:F350	R:R:L349	37.0551	7.31	Yes	No	0	9	9
41	R:R:F350	R:R:L240	12.4502	6.09	Yes	No	0	9	9
42	R:R:L293	R:R:R277	14.9	7.29	No	No	0	4	8
43	R:R:I297	R:R:W294	14.9	3.52	No	No	0	7	7
44	R:R:F312	R:R:F350	22.8318	3.22	Yes	Yes	2	9	9
45	R:R:F312	R:R:I316	10.2617	10.05	Yes	No	0	9	7
46	R:R:F312	R:R:I347	11.3281	5.02	Yes	Yes	2	9	8
47	R:R:E373	R:R:Y354	19.7824	7.86	Yes	Yes	1	7	8
48	R:R:E373	R:R:F357	12.1504	5.83	Yes	Yes	1	7	6
49	R:R:F230	R:R:V226	10.9341	3.93	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K20	R:R:D132	6.91	0	No	No	0	1	0	1
R:R:Q135	R:R:Y139	7.89	0	No	Yes	3	4	1	1
L:L:Y13	R:R:Q135	19.16	0	No	No	0	3	0	1
L:L:Y13	R:R:T136	7.49	0	No	No	0	2	0	1
R:R:F138	R:R:V142	3.93	0	No	No	5	5	2	1
L:L:F6	R:R:Y139	6.19	3	Yes	Yes	0	4	0	1
L:L:S9	R:R:Y139	5.09	0	No	Yes	0	4	0	1
L:L:Y10	R:R:Y139	9.93	0	No	Yes	0	4	0	1
L:L:F6	R:R:V142	7.87	3	Yes	No	0	5	0	1
R:R:K143	R:R:Y146	4.78	0	No	Yes	5	8	2	1
R:R:L374	R:R:Y146	4.69	3	No	Yes	7	8	1	1
L:L:F6	R:R:Y146	6.19	3	Yes	Yes	0	8	0	1
R:R:R188	R:R:Y150	8.23	0	Yes	No	8	8	1	2
R:R:V192	R:R:Y150	7.57	0	No	No	7	8	2	2
R:R:N229	R:R:R188	8.44	0	No	Yes	8	8	2	1
R:R:F230	R:R:R188	3.21	0	Yes	Yes	8	8	2	1
L:L:D3	R:R:R188	4.76	0	Yes	Yes	0	8	0	1
R:R:F222	R:R:V192	3.93	0	Yes	No	7	7	1	2
R:R:K195	R:R:M219	8.64	0	No	No	7	5	2	2
R:R:F222	R:R:K195	9.93	0	Yes	No	7	7	1	2
L:L:Y10	R:R:L199	4.69	0	No	No	0	7	0	1
R:R:M219	R:R:Q223	5.44	0	No	Yes	5	7	2	1
R:R:F222	R:R:Q223	8.2	0	Yes	Yes	7	7	1	1
L:L:D3	R:R:F222	4.78	0	Yes	Yes	0	7	0	1
R:R:Q223	R:R:W273	5.48	7	Yes	No	7	8	1	2
R:R:I297	R:R:Q223	5.49	7	No	Yes	7	7	2	1
L:L:H1	R:R:Q223	8.65	0	Yes	Yes	0	7	0	1
R:R:F230	R:R:V226	3.93	0	Yes	No	8	5	2	1
L:L:H1	R:R:V226	12.45	0	Yes	No	0	5	0	1
R:R:F230	R:R:Y354	10.32	0	Yes	Yes	8	8	2	2
R:R:I297	R:R:W273	18.79	7	No	No	7	8	2	2
L:L:T7	R:R:D287	5.78	0	No	No	0	5	0	1
L:L:S11	R:R:D287	7.36	0	No	No	0	5	0	1
L:L:D8	R:R:T288	5.78	0	No	No	0	4	0	1
R:R:I289	R:R:W294	10.57	0	No	No	8	7	1	2
L:L:D8	R:R:I289	7	0	No	No	0	8	0	1
R:R:I297	R:R:W294	3.52	7	No	No	7	7	2	2
R:R:E373	R:R:Y354	7.86	1	Yes	Yes	7	8	1	2
R:R:F357	R:R:F360	7.5	1	Yes	Yes	6	5	2	2
R:R:F357	R:R:K369	6.2	1	Yes	Yes	6	8	2	1
R:R:F357	R:R:F372	5.36	1	Yes	Yes	6	4	2	2
R:R:E373	R:R:F357	5.83	1	Yes	Yes	7	6	1	2
R:R:F360	R:R:K369	4.96	1	Yes	Yes	5	8	2	1
R:R:D362	R:R:K369	8.3	0	No	Yes	4	8	1	1
L:L:I5	R:R:D362	12.59	0	No	No	0	4	0	1
L:L:S2	R:R:K369	4.59	0	No	Yes	0	8	0	1
L:L:F6	R:R:M370	6.22	3	Yes	No	0	6	0	1
R:R:E373	R:R:F372	4.66	1	Yes	Yes	7	4	1	2
L:L:S2	R:R:E373	7.19	0	No	Yes	0	7	0	1
L:L:D3	R:R:L374	5.43	0	Yes	No	0	7	0	1
L:L:F6	R:R:L374	3.65	3	Yes	No	0	7	0	1
R:R:T147	R:R:Y146	2.5	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6VN7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.18
Number of Linked Nodes	258
Number of Links	267
Number of Hubs	34
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	39
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	50
Number Of Links MetaPath	49
Number of Shortest Paths	38534
Length Of Smallest Path	3
Average Path Length	12.9296
Length of Longest Path	29
Minimum Path Strength	0.97
Average Path Strength	6.49112
Maximum Path Strength	25.92
Minimum Path Correlation	0.7
Average Path Correlation	0.938799
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.9485
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9611
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • multicellular organismal process • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of chemokine (C-C motif) ligand 5 production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell cycle • cell cycle • regulation of cell cycle • cell-cell signaling • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of G protein-coupled receptor signaling pathway • protein localization • regulation of localization • cellular localization • regulation of protein localization • localization • regulation of cellular localization • cellular macromolecule localization • macromolecule localization • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of transferase activity • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • export from cell • establishment of localization • regulation of secretion • peptide transport • positive regulation of growth hormone secretion • positive regulation of transport • peptide hormone secretion • hormone transport • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • establishment of protein localization • protein localization to extracellular region • establishment of protein localization to extracellular region • protein secretion • protein transport • insulin secretion • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • cellular component organization or biogenesis • system development • somatodendritic compartment • cell body • perikaryon • neuronal cell body • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular region • extracellular space • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of protein secretion • regulation of establishment of protein localization • regulation of protein transport • regulation of insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32241
Sequence	>6VN7_nogp_Chain_R A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F R K L H C T R N Y I H M H L F I S F I L R A A A V F I K D L A L F D S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S F F S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E D Y G C W D T I N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L R P P P Y S R L A R S T L L L I P L F G V H Y I M F A F F P D N F K P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E V Q A E L R R K W R R W H L Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8E3Z	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	2.7	2022-11-23	10.1038/s41467-022-34629-3
	8E3Z (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-		2.7	2022-11-23	10.1038/s41467-022-34629-3
	8E3Y	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	10.1038/s41467-022-34629-3
	8E3Y (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	10.1038/s41467-022-34629-3
	6VN7	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.2	2020-09-02	10.1038/s41467-020-17933-8
	6VN7 (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP	-		3.2	2020-09-02	10.1038/s41467-020-17933-8

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