psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L131	R:R:Q134	6.65	No	No	0	2	1
2	L:L:K20	R:R:D132	6.91	No	No	0	0	1
3	R:R:Q135	R:R:Y139	7.89	No	Yes	0	3	4
4	L:L:Y13	R:R:Q135	19.16	No	No	0	0	3
5	L:L:Y13	R:R:T136	7.49	No	No	0	0	2
6	R:R:F138	R:R:V142	3.93	No	No	0	5	5
7	R:R:E367	R:R:F138	5.83	No	No	0	3	5
8	L:L:F6	R:R:Y139	6.19	Yes	Yes	0	0	4
9	L:L:S9	R:R:Y139	5.09	No	Yes	0	0	4
10	L:L:Y10	R:R:Y139	9.93	No	Yes	0	0	4
11	L:L:F6	R:R:V142	7.87	Yes	No	0	0	5
12	R:R:K143	R:R:Y146	4.78	No	Yes	0	5	8
13	R:R:D196	R:R:K143	5.53	No	No	0	7	5
14	R:R:L374	R:R:Y146	4.69	No	Yes	3	7	8
15	L:L:F6	R:R:Y146	6.19	Yes	Yes	3	0	8
16	R:R:R188	R:R:Y150	8.23	Yes	No	0	8	8
17	R:R:V192	R:R:Y150	7.57	No	No	0	7	8
18	R:R:S378	R:R:Y150	10.17	No	No	0	9	8
19	R:R:F382	R:R:L152	15.83	No	No	0	6	5
20	R:R:G381	R:R:S153	3.71	No	No	0	9	9
21	R:R:A189	R:R:L154	4.73	No	Yes	0	7	6
22	R:R:F382	R:R:T156	6.49	No	No	0	6	6
23	R:R:F182	R:R:L157	8.53	Yes	Yes	0	8	9
24	R:R:F185	R:R:L157	3.65	Yes	Yes	0	8	9
25	R:R:I186	R:R:L158	5.71	No	No	0	6	3
26	R:R:F390	R:R:V159	3.93	No	No	0	9	5
27	R:R:A160	R:R:C389	3.61	No	No	0	9	9
28	R:R:F182	R:R:T161	3.89	Yes	No	0	8	6
29	R:R:C389	R:R:I163	4.91	No	No	0	9	8
30	R:R:L164	R:R:M179	4.24	No	No	0	7	6
31	R:R:F167	R:R:L170	6.09	Yes	No	0	6	9
32	R:R:F167	R:R:L399	4.87	Yes	No	0	6	5
33	R:R:F167	R:R:K402	3.72	Yes	No	0	6	5
34	R:R:E394	R:R:K169	6.75	No	No	0	9	7
35	R:R:E398	R:R:K169	9.45	No	No	0	7	7
36	R:R:E394	R:R:L170	6.63	No	No	0	9	9
37	R:R:L170	R:R:V395	7.45	No	No	0	9	9
38	R:R:H171	R:R:Y176	8.71	No	No	0	8	6
39	R:R:T173	R:R:Y239	6.24	No	Yes	0	7	8
40	R:R:E251	R:R:T173	11.29	No	No	0	6	7
41	R:R:R252	R:R:T173	3.88	No	No	0	5	7
42	R:R:N175	R:R:R174	12.05	No	No	4	9	9
43	R:R:H178	R:R:R174	4.51	No	No	4	9	9
44	R:R:H178	R:R:N175	3.83	No	No	4	9	9
45	R:R:F255	R:R:Y176	4.13	No	No	0	6	6
46	R:R:E236	R:R:I177	4.1	No	No	0	9	9
47	R:R:I177	R:R:Y239	8.46	No	Yes	0	9	8
48	R:R:H180	R:R:W232	12.7	No	Yes	0	9	9
49	R:R:H180	R:R:I259	6.63	No	No	0	9	4
50	R:R:F182	R:R:L181	3.65	Yes	Yes	0	8	9
51	R:R:F185	R:R:L181	8.53	Yes	Yes	0	8	9
52	R:R:L181	R:R:L233	4.15	Yes	No	0	9	9
53	R:R:E236	R:R:L181	15.9	No	Yes	0	9	9
54	R:R:N229	R:R:S184	4.47	No	No	0	8	9
55	R:R:F185	R:R:N229	8.46	Yes	No	0	8	8
56	R:R:N229	R:R:R188	8.44	No	Yes	0	8	8
57	R:R:F230	R:R:R188	3.21	Yes	Yes	0	8	8
58	L:L:D3	R:R:R188	4.76	Yes	Yes	0	0	8
59	R:R:A191	R:R:F221	4.16	No	No	5	6	4
60	R:R:A191	R:R:C225	3.61	No	No	5	6	6
61	R:R:F222	R:R:V192	3.93	Yes	No	0	7	7
62	R:R:K195	R:R:M219	8.64	No	No	0	7	5
63	R:R:F222	R:R:K195	9.93	Yes	No	0	7	7
64	L:L:Y10	R:R:L199	4.69	No	No	0	0	7
65	R:R:D201	R:R:F200	4.78	No	No	0	4	4
66	R:R:C215	R:R:C285	7.28	No	No	0	9	9
67	R:R:D282	R:R:K216	8.3	No	No	6	6	8
68	R:R:K216	R:R:W286	27.85	No	Yes	6	8	9
69	R:R:M219	R:R:Q223	5.44	No	Yes	0	5	7
70	R:R:C225	R:R:F221	8.38	No	No	5	6	4
71	R:R:F222	R:R:Q223	8.2	Yes	Yes	0	7	7
72	L:L:D3	R:R:F222	4.78	Yes	Yes	0	0	7
73	R:R:Q223	R:R:W273	5.48	Yes	No	7	7	8
74	R:R:I297	R:R:Q223	5.49	No	Yes	7	7	7
75	L:L:H1	R:R:Q223	8.65	Yes	Yes	0	0	7
76	R:R:W263	R:R:Y224	7.72	No	Yes	0	8	9
77	R:R:S267	R:R:Y224	3.82	No	Yes	0	3	9
78	R:R:T270	R:R:Y224	8.74	No	Yes	0	6	9
79	R:R:F230	R:R:V226	3.93	Yes	No	0	8	5
80	L:L:H1	R:R:V226	12.45	Yes	No	0	0	5
81	R:R:F231	R:R:M227	3.73	Yes	No	8	5	5
82	R:R:M227	R:R:P266	6.71	No	Yes	8	5	9
83	R:R:I301	R:R:M227	4.37	No	No	0	7	5
84	R:R:A228	R:R:P266	3.74	No	Yes	0	8	9
85	R:R:F230	R:R:I301	10.05	Yes	No	0	8	7
86	R:R:F230	R:R:Y354	10.32	Yes	Yes	0	8	8
87	R:R:F231	R:R:P266	10.11	Yes	Yes	8	5	9
88	R:R:V235	R:R:W232	6.13	No	Yes	0	7	9
89	R:R:G262	R:R:W232	8.44	No	Yes	0	9	9
90	R:R:W232	R:R:W263	15.93	Yes	No	0	9	8
91	R:R:L234	R:R:S304	9.01	No	No	0	8	7
92	R:R:E236	R:R:L349	5.3	No	No	0	9	9
93	R:R:G237	R:R:N308	3.39	No	No	2	9	9
94	R:R:F350	R:R:G237	6.02	Yes	No	2	9	9
95	R:R:L243	R:R:Y239	12.89	No	Yes	0	7	8
96	R:R:Y239	R:R:Y258	4.96	Yes	No	0	8	7
97	R:R:L240	R:R:L244	4.15	No	No	0	9	8
98	R:R:I315	R:R:L240	7.14	No	No	0	9	9
99	R:R:F350	R:R:L240	6.09	Yes	No	0	9	9
100	R:R:A245	R:R:Y241	8.01	No	Yes	0	7	8
101	R:R:L311	R:R:Y241	5.86	No	Yes	0	8	8
102	R:R:C314	R:R:Y241	4.03	No	Yes	0	8	8
103	R:R:T242	R:R:Y258	4.99	No	No	0	7	7
104	R:R:I318	R:R:L244	4.28	No	No	0	8	8
105	R:R:F248	R:R:S247	9.25	No	No	0	6	7
106	R:R:F249	R:R:K253	3.72	No	No	0	5	4
107	R:R:F249	R:R:Y254	15.47	No	No	0	5	4
108	R:R:Y254	R:R:Y258	9.93	No	No	0	4	7
109	R:R:F255	R:R:I259	7.54	No	No	0	6	4
110	R:R:P266	R:R:V265	3.53	Yes	No	0	9	5
111	R:R:F269	R:R:P300	13	No	No	0	6	9
112	R:R:R277	R:R:W273	11	No	No	0	8	8
113	R:R:I297	R:R:W273	18.79	No	No	7	7	8
114	R:R:T274	R:R:W286	4.85	No	Yes	0	6	9
115	R:R:H279	R:R:I275	3.98	No	No	0	1	4
116	R:R:R277	R:R:W286	23.99	No	Yes	0	8	9
117	R:R:L293	R:R:R277	7.29	No	No	0	4	8
118	R:R:I278	R:R:W286	4.7	No	Yes	0	3	9
119	R:R:E281	R:R:F280	7	No	No	0	6	3
120	R:R:E281	R:R:Y283	7.86	No	No	0	6	3
121	R:R:D282	R:R:W286	5.58	No	Yes	6	6	9
122	R:R:N290	R:R:Y283	5.81	No	No	0	3	3
123	L:L:T7	R:R:D287	5.78	No	No	0	0	5
124	L:L:S11	R:R:D287	7.36	No	No	0	0	5
125	L:L:D8	R:R:T288	5.78	No	No	0	0	4
126	R:R:I289	R:R:W294	10.57	No	No	0	8	7
127	L:L:D8	R:R:I289	7	No	No	0	0	8
128	R:R:L293	R:R:N290	4.12	No	No	0	4	3
129	R:R:I297	R:R:W294	3.52	No	No	0	7	7
130	R:R:K298	R:R:W294	6.96	No	No	0	7	7
131	R:R:K298	R:R:L302	7.05	No	No	0	7	4
132	R:R:G299	R:R:P300	4.06	No	No	0	4	9
133	R:R:I305	R:R:Y354	4.84	No	Yes	1	7	8
134	R:R:F350	R:R:N308	10.87	Yes	No	2	9	9
135	R:R:F309	R:R:I313	8.79	No	No	0	5	5
136	R:R:F309	R:R:I355	12.56	No	Yes	0	5	5
137	R:R:F312	R:R:I316	10.05	Yes	No	0	9	7
138	R:R:F312	R:R:L346	6.09	Yes	No	2	9	9
139	R:R:F312	R:R:I347	5.02	Yes	Yes	2	9	8
140	R:R:F312	R:R:F350	3.22	Yes	Yes	2	9	9
141	R:R:F312	R:R:V352	13.11	Yes	No	2	9	6
142	R:R:I316	R:R:T343	6.08	No	No	0	7	9
143	R:R:Q321	R:R:R317	8.18	No	No	0	7	7
144	R:R:L320	R:R:R324	3.64	No	No	0	5	6
145	R:R:L323	R:R:R338	6.07	No	No	0	8	8
146	R:R:P325	R:R:P326	5.84	No	No	0	6	6
147	R:R:R338	R:R:R341	5.33	No	No	0	8	8
148	R:R:L345	R:R:L387	5.54	No	No	0	8	8
149	R:R:F350	R:R:L346	8.53	Yes	No	2	9	9
150	R:R:I347	R:R:P348	3.39	Yes	No	0	8	9
151	R:R:I347	R:R:V352	10.75	Yes	No	2	8	6
152	R:R:P348	R:R:V383	3.53	No	No	0	9	5
153	R:R:F350	R:R:L349	7.31	Yes	No	0	9	9
154	R:R:L349	R:R:Y388	15.24	No	No	0	9	8
155	R:R:G351	R:R:H353	3.18	No	Yes	0	9	8
156	R:R:H353	R:R:Y354	20.69	Yes	Yes	1	8	8
157	R:R:H353	R:R:V376	6.92	Yes	No	0	8	5
158	R:R:H353	R:R:Q380	9.89	Yes	No	1	8	9
159	R:R:E373	R:R:Y354	7.86	Yes	Yes	1	7	8
160	R:R:Q380	R:R:Y354	7.89	No	Yes	1	9	8
161	R:R:F357	R:R:F360	7.5	Yes	Yes	1	6	5
162	R:R:F357	R:R:K369	6.2	Yes	Yes	1	6	8
163	R:R:F357	R:R:F372	5.36	Yes	Yes	1	6	4
164	R:R:E373	R:R:F357	5.83	Yes	Yes	1	7	6
165	R:R:F360	R:R:P361	7.22	Yes	No	0	5	8
166	R:R:F360	R:R:F364	5.36	Yes	No	1	5	3
167	R:R:F360	R:R:K365	6.2	Yes	Yes	1	5	2
168	R:R:F360	R:R:K369	4.96	Yes	Yes	1	5	8
169	R:R:D362	R:R:K369	8.3	No	Yes	0	4	8
170	L:L:I5	R:R:D362	12.59	No	No	0	0	4
171	R:R:F364	R:R:K365	7.44	No	Yes	1	3	2
172	R:R:K365	R:R:V368	6.07	Yes	No	0	2	4
173	L:L:S2	R:R:K369	4.59	No	Yes	0	0	8
174	L:L:F6	R:R:M370	6.22	Yes	No	0	0	6
175	R:R:E373	R:R:F372	4.66	Yes	Yes	1	7	4
176	R:R:F372	R:R:V376	6.55	Yes	No	0	4	5
177	L:L:S2	R:R:E373	7.19	No	Yes	0	0	7
178	L:L:D3	R:R:L374	5.43	Yes	No	0	0	7
179	L:L:F6	R:R:L374	3.65	Yes	No	3	0	7
180	R:R:G377	R:R:Q380	3.29	No	No	0	6	9
181	R:R:F382	R:R:I386	10.05	No	No	0	6	5
182	R:R:N392	R:R:V395	4.43	No	No	0	9	9
183	R:R:K402	R:R:R405	3.71	No	No	0	5	7
184	L:L:D3	L:L:H1	5.04	Yes	Yes	0	0	0
185	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
186	L:L:G4	L:L:T7	3.64	No	No	0	0	0
187	L:L:D8	L:L:R12	9.53	No	No	0	0	0
188	L:L:R14	L:L:Y10	10.29	No	No	0	0	0
189	L:L:M17	L:L:Y13	13.17	No	No	0	0	0
190	R:R:C225	R:R:L187	3.17	No	No	0	6	6
191	R:R:T274	R:R:V220	3.17	No	No	0	6	5
192	R:R:A385	R:R:L157	3.15	No	Yes	0	8	9
193	R:R:M179	R:R:S165	3.07	No	No	0	6	3
194	R:R:I261	R:R:V235	3.07	No	No	0	6	7
195	R:R:I148	R:R:T144	3.04	No	No	0	5	4
196	R:R:I183	R:R:T161	3.04	No	No	0	3	6
197	R:R:F379	R:R:G149	3.01	No	No	0	7	8
198	R:R:F185	R:R:G381	3.01	Yes	No	0	8	9
199	R:R:L319	R:R:S342	3	No	No	0	8	9
200	R:R:L234	R:R:V307	2.98	No	No	0	8	6
201	R:R:L387	R:R:V383	2.98	No	No	0	8	5
202	R:R:L339	R:R:T343	2.95	No	No	0	8	9
203	R:R:I305	R:R:I355	2.94	No	Yes	1	7	5
204	R:R:F231	R:R:P300	2.89	Yes	No	0	5	9
205	R:R:P325	R:R:R324	2.88	No	No	0	6	6
206	R:R:E133	R:R:S130	2.87	No	No	0	2	1
207	R:R:I186	R:R:L154	2.85	No	Yes	0	6	6
208	R:R:I186	R:R:L157	2.85	No	Yes	0	6	9
209	R:R:I386	R:R:L391	2.85	No	No	0	5	6
210	R:R:G257	R:R:W256	2.81	No	No	0	2	3
211	R:R:P266	R:R:Y224	2.78	Yes	Yes	0	9	9
212	R:R:A160	R:R:F182	2.77	No	Yes	0	9	8
213	R:R:L238	R:R:L311	2.77	No	No	0	6	8
214	L:L:L23	L:L:L27	2.77	No	No	0	0	0
215	R:R:L391	R:R:Q396	2.66	No	No	0	6	7
216	R:R:H279	R:R:I278	2.65	No	No	0	1	3
217	R:R:F138	R:R:V371	2.62	No	No	0	5	5
218	R:R:F182	R:R:V384	2.62	Yes	No	0	8	9
219	R:R:F185	R:R:V384	2.62	Yes	No	0	8	9
220	R:R:F167	R:R:I163	2.51	Yes	No	0	6	8
221	R:R:F390	R:R:I163	2.51	No	No	0	9	8
222	R:R:F221	R:R:I194	2.51	No	No	0	4	5
223	R:R:T147	R:R:Y146	2.5	No	Yes	0	7	8
224	R:R:F357	R:R:M356	2.49	Yes	No	1	6	6
225	R:R:F372	R:R:M356	2.49	Yes	No	1	4	6
226	R:R:F193	R:R:L154	2.44	No	Yes	0	7	6
227	R:R:F182	R:R:L164	2.44	Yes	No	0	8	7
228	R:R:F231	R:R:L234	2.44	Yes	No	0	5	8
229	R:R:L345	R:R:R341	2.43	No	No	0	8	8
230	R:R:I315	R:R:Y241	2.42	No	Yes	0	9	8
231	R:R:K298	R:R:W295	2.32	No	No	0	7	6
232	R:R:L187	R:R:W263	2.28	No	No	0	6	8
233	R:R:H178	R:R:Y388	2.18	No	No	0	9	8
234	R:R:G149	R:R:S378	1.86	No	No	0	8	9
235	R:R:G264	R:R:S267	1.86	No	No	0	7	3
236	R:R:G140	R:R:K143	1.74	No	No	0	3	5
237	R:R:C215	R:R:S212	1.72	No	No	0	9	3
238	R:R:G151	R:R:L154	1.71	No	Yes	0	6	6
239	R:R:G257	R:R:L260	1.71	No	No	0	2	3
240	R:R:A245	R:R:V246	1.7	No	No	0	7	4
241	R:R:A385	R:R:T156	1.68	No	No	0	8	6
242	R:R:D282	R:R:G284	1.68	No	No	0	6	4
243	R:R:K365	R:R:P366	1.67	Yes	No	0	2	5
244	R:R:S291	R:R:S292	1.63	No	No	0	5	3
245	R:R:A218	R:R:I194	1.62	No	No	0	5	5
246	R:R:A276	R:R:I296	1.62	No	No	0	4	8
247	R:R:A358	R:R:I305	1.62	No	No	1	6	7
248	R:R:A358	R:R:I355	1.62	No	Yes	1	6	5
249	R:R:T303	R:R:V307	1.59	No	No	0	3	6
250	R:R:A129	R:R:L131	1.58	No	No	0	2	2
251	R:R:A276	R:R:L293	1.58	No	No	0	4	4
252	R:R:C172	R:R:N175	1.57	No	No	0	8	9
253	R:R:I296	R:R:V272	1.54	No	No	0	8	4
254	R:R:M137	R:R:S141	1.53	No	No	0	2	4
255	L:L:K15	L:L:S11	1.53	No	No	0	0	0
256	R:R:I318	R:R:K322	1.45	No	No	0	8	9
257	R:R:P335	R:R:R338	1.44	No	No	0	7	8
258	L:L:K21	L:L:M17	1.44	No	No	0	0	0
259	R:R:I355	R:R:L306	1.43	Yes	No	0	5	3
260	R:R:I316	R:R:L319	1.43	No	No	0	7	8
261	R:R:I347	R:R:L344	1.43	Yes	No	0	8	7
262	R:R:L320	R:R:L339	1.38	No	No	0	5	8
263	R:R:F379	R:R:V375	1.31	No	No	0	7	5
264	R:R:E398	R:R:R401	1.16	No	No	0	7	7
265	R:R:H171	R:R:R168	1.13	No	No	0	8	7
266	R:R:R404	R:R:W403	1	No	No	0	3	6
267	R:R:W403	R:R:W406	0.94	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y139	7.275	4	0	4
2	R:R:Y146	4.54	4	3	8
3	R:R:L154	2.9325	4	0	6
4	R:R:L157	4.545	4	0	9
5	R:R:F167	4.2975	4	0	6
6	R:R:L181	8.0575	4	0	9
7	R:R:F182	3.98333	6	0	8
8	R:R:F185	5.254	5	0	8
9	R:R:R188	6.16	4	0	8
10	R:R:F222	6.71	4	0	7
11	R:R:Q223	6.652	5	7	7
12	R:R:Y224	5.765	4	0	9
13	R:R:F230	6.8775	4	0	8
14	R:R:F231	4.7925	4	8	5
15	R:R:W232	10.8	4	0	9
16	R:R:Y239	8.1375	4	0	8
17	R:R:Y241	5.08	4	0	8
18	R:R:P266	5.374	5	8	9
19	R:R:W286	13.394	5	6	9
20	R:R:F312	7.498	5	2	9
21	R:R:I347	5.1475	4	2	8
22	R:R:F350	7.00667	6	2	9
23	R:R:H353	10.17	4	1	8
24	R:R:Y354	10.32	5	1	8
25	R:R:I355	4.6375	4	1	5
26	R:R:F357	5.476	5	1	6
27	R:R:F360	6.248	5	1	5
28	R:R:K365	5.345	4	1	2
29	R:R:K369	6.0125	4	1	8
30	R:R:F372	4.765	4	1	4
31	R:R:E373	6.385	4	1	7
32	L:L:H1	7.33	4	0	0
33	L:L:D3	5.0025	4	0	0
34	L:L:F6	6.024	5	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F6	R:R:Y139	12.4545	6.19	Yes	Yes	0	0	4
2	L:L:F6	R:R:L374	19.3327	3.65	Yes	No	3	0	7
3	L:L:D3	R:R:L374	26.5879	5.43	Yes	No	0	0	7
4	L:L:D3	R:R:R188	63.5787	4.76	Yes	Yes	0	0	8
5	L:L:D3	R:R:F222	24.2023	4.78	Yes	Yes	0	0	7
6	R:R:F185	R:R:L157	29.5559	3.65	Yes	Yes	0	8	9
7	R:R:F185	R:R:N229	99.7859	8.46	Yes	No	0	8	8
8	R:R:N229	R:R:R188	100	8.44	No	Yes	0	8	8
9	R:R:F182	R:R:L157	20.6818	8.53	Yes	Yes	0	8	9
10	R:R:F182	R:R:L181	24.6991	3.65	Yes	Yes	0	8	9
11	R:R:F185	R:R:L181	60.1782	8.53	Yes	Yes	0	8	9
12	R:R:F182	R:R:V384	16.339	2.62	Yes	No	0	8	9
13	R:R:F185	R:R:V384	16.9729	2.62	Yes	No	0	8	9
14	R:R:C389	R:R:I163	35.0679	4.91	No	No	0	9	8
15	R:R:A160	R:R:C389	37.5262	3.61	No	No	0	9	9
16	R:R:A160	R:R:F182	39.976	2.77	No	Yes	0	9	8
17	R:R:F167	R:R:I163	27.6286	2.51	Yes	No	0	6	8
18	R:R:F167	R:R:L170	17.7695	6.09	Yes	No	0	6	9
19	R:R:E394	R:R:L170	10.1589	6.63	No	No	0	9	9
20	R:R:W232	R:R:W263	11.3881	15.93	Yes	No	0	9	8
21	R:R:W263	R:R:Y224	18.8531	7.72	No	Yes	0	8	9
22	R:R:P266	R:R:Y224	22.9303	2.78	Yes	Yes	0	9	9
23	R:R:M227	R:R:P266	25.076	6.71	No	Yes	8	5	9
24	R:R:I301	R:R:M227	34.3398	4.37	No	No	0	7	5
25	R:R:F230	R:R:I301	35.2349	10.05	Yes	No	0	8	7
26	R:R:F230	R:R:R188	49.0728	3.21	Yes	Yes	0	8	8
27	R:R:E236	R:R:L181	51.544	15.9	No	Yes	0	9	9
28	R:R:E236	R:R:I177	12.5187	4.1	No	No	0	9	9
29	R:R:I177	R:R:Y239	11.4095	8.46	No	Yes	0	9	8
30	R:R:E236	R:R:L349	42.1945	5.3	No	No	0	9	9
31	R:R:F222	R:R:Q223	22.4378	8.2	Yes	Yes	0	7	7
32	L:L:H1	R:R:Q223	30.6951	8.65	Yes	Yes	0	0	7
33	L:L:D3	L:L:H1	25.8169	5.04	Yes	Yes	0	0	0
34	R:R:R277	R:R:W286	16.7245	23.99	No	Yes	0	8	9
35	R:R:R277	R:R:W273	32.7594	11	No	No	0	8	8
36	R:R:Q223	R:R:W273	33.7659	5.48	Yes	No	7	7	8
37	R:R:I297	R:R:Q223	15.9921	5.49	No	Yes	7	7	7
38	L:L:H1	R:R:V226	10.3002	12.45	Yes	No	0	0	5
39	R:R:F230	R:R:Y354	31.6031	10.32	Yes	Yes	0	8	8
40	R:R:F350	R:R:L349	37.0551	7.31	Yes	No	0	9	9
41	R:R:F350	R:R:L240	12.4502	6.09	Yes	No	0	9	9
42	R:R:L293	R:R:R277	14.9	7.29	No	No	0	4	8
43	R:R:I297	R:R:W294	14.9	3.52	No	No	0	7	7
44	R:R:F312	R:R:F350	22.8318	3.22	Yes	Yes	2	9	9
45	R:R:F312	R:R:I316	10.2617	10.05	Yes	No	0	9	7
46	R:R:F312	R:R:I347	11.3281	5.02	Yes	Yes	2	9	8
47	R:R:E373	R:R:Y354	19.7824	7.86	Yes	Yes	1	7	8
48	R:R:E373	R:R:F357	12.1504	5.83	Yes	Yes	1	7	6
49	R:R:F230	R:R:V226	10.9341	3.93	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K20	R:R:D132	6.91	0	No	No	0	1	0	1
R:R:Q135	R:R:Y139	7.89	0	No	Yes	3	4	1	1
L:L:Y13	R:R:Q135	19.16	0	No	No	0	3	0	1
L:L:Y13	R:R:T136	7.49	0	No	No	0	2	0	1
R:R:F138	R:R:V142	3.93	0	No	No	5	5	2	1
L:L:F6	R:R:Y139	6.19	3	Yes	Yes	0	4	0	1
L:L:S9	R:R:Y139	5.09	0	No	Yes	0	4	0	1
L:L:Y10	R:R:Y139	9.93	0	No	Yes	0	4	0	1
L:L:F6	R:R:V142	7.87	3	Yes	No	0	5	0	1
R:R:K143	R:R:Y146	4.78	0	No	Yes	5	8	2	1
R:R:L374	R:R:Y146	4.69	3	No	Yes	7	8	1	1
L:L:F6	R:R:Y146	6.19	3	Yes	Yes	0	8	0	1
R:R:R188	R:R:Y150	8.23	0	Yes	No	8	8	1	2
R:R:V192	R:R:Y150	7.57	0	No	No	7	8	2	2
R:R:N229	R:R:R188	8.44	0	No	Yes	8	8	2	1
R:R:F230	R:R:R188	3.21	0	Yes	Yes	8	8	2	1
L:L:D3	R:R:R188	4.76	0	Yes	Yes	0	8	0	1
R:R:F222	R:R:V192	3.93	0	Yes	No	7	7	1	2
R:R:K195	R:R:M219	8.64	0	No	No	7	5	2	2
R:R:F222	R:R:K195	9.93	0	Yes	No	7	7	1	2
L:L:Y10	R:R:L199	4.69	0	No	No	0	7	0	1
R:R:M219	R:R:Q223	5.44	0	No	Yes	5	7	2	1
R:R:F222	R:R:Q223	8.2	0	Yes	Yes	7	7	1	1
L:L:D3	R:R:F222	4.78	0	Yes	Yes	0	7	0	1
R:R:Q223	R:R:W273	5.48	7	Yes	No	7	8	1	2
R:R:I297	R:R:Q223	5.49	7	No	Yes	7	7	2	1
L:L:H1	R:R:Q223	8.65	0	Yes	Yes	0	7	0	1
R:R:F230	R:R:V226	3.93	0	Yes	No	8	5	2	1
L:L:H1	R:R:V226	12.45	0	Yes	No	0	5	0	1
R:R:F230	R:R:Y354	10.32	0	Yes	Yes	8	8	2	2
R:R:I297	R:R:W273	18.79	7	No	No	7	8	2	2
L:L:T7	R:R:D287	5.78	0	No	No	0	5	0	1
L:L:S11	R:R:D287	7.36	0	No	No	0	5	0	1
L:L:D8	R:R:T288	5.78	0	No	No	0	4	0	1
R:R:I289	R:R:W294	10.57	0	No	No	8	7	1	2
L:L:D8	R:R:I289	7	0	No	No	0	8	0	1
R:R:I297	R:R:W294	3.52	7	No	No	7	7	2	2
R:R:E373	R:R:Y354	7.86	1	Yes	Yes	7	8	1	2
R:R:F357	R:R:F360	7.5	1	Yes	Yes	6	5	2	2
R:R:F357	R:R:K369	6.2	1	Yes	Yes	6	8	2	1
R:R:F357	R:R:F372	5.36	1	Yes	Yes	6	4	2	2
R:R:E373	R:R:F357	5.83	1	Yes	Yes	7	6	1	2
R:R:F360	R:R:K369	4.96	1	Yes	Yes	5	8	2	1
R:R:D362	R:R:K369	8.3	0	No	Yes	4	8	1	1
L:L:I5	R:R:D362	12.59	0	No	No	0	4	0	1
L:L:S2	R:R:K369	4.59	0	No	Yes	0	8	0	1
L:L:F6	R:R:M370	6.22	3	Yes	No	0	6	0	1
R:R:E373	R:R:F372	4.66	1	Yes	Yes	7	4	1	2
L:L:S2	R:R:E373	7.19	0	No	Yes	0	7	0	1
L:L:D3	R:R:L374	5.43	0	Yes	No	0	7	0	1
L:L:F6	R:R:L374	3.65	3	Yes	No	0	7	0	1
R:R:T147	R:R:Y146	2.5	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6VN7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.18
Number of Linked Nodes	258
Number of Links	267
Number of Hubs	34
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	39
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	50
Number Of Links MetaPath	49
Number of Shortest Paths	38534
Length Of Smallest Path	3
Average Path Length	12.9296
Length of Longest Path	29
Minimum Path Strength	0.97
Average Path Strength	6.49112
Maximum Path Strength	25.92
Minimum Path Correlation	0.7
Average Path Correlation	0.938855
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.9401
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9611
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32241
Sequence	>6VN7_nogp_Chain_R A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F R K L H C T R N Y I H M H L F I S F I L R A A A V F I K D L A L F D S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S F F S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E D Y G C W D T I N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L R P P P Y S R L A R S T L L L I P L F G V H Y I M F A F F P D N F K P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E V Q A E L R R K W R R W H L Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	PACAP27
UniProt	P18509
Sequence	>6VN7_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6VN7	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.2	2020-09-02	doi.org/10.1038/s41467-020-17933-8
	6VN7 (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		3.2	2020-09-02	doi.org/10.1038/s41467-020-17933-8
	8E3Y	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Y (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Z	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	2.7	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Z (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-		2.7	2022-11-23	doi.org/10.1038/s41467-022-34629-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6VN7_nogp.zip

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