psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
2	L:L:H1	R:R:F222	4.53	Yes	Yes	1	0	7
3	L:L:H1	R:R:Q223	7.42	Yes	Yes	1	0	7
4	L:L:H1	R:R:V226	12.45	Yes	No	1	0	5
5	L:L:H1	R:R:W294	9.52	Yes	Yes	1	0	7
6	L:L:S2	R:R:E373	11.5	No	No	0	0	7
7	L:L:D3	R:R:Y150	5.75	Yes	Yes	1	0	8
8	L:L:D3	R:R:R188	4.76	Yes	Yes	1	0	8
9	L:L:D3	R:R:F222	5.97	Yes	Yes	1	0	7
10	L:L:D3	R:R:L374	5.43	Yes	No	1	0	7
11	L:L:G4	L:L:T7	3.64	No	No	0	0	0
12	L:L:I5	R:R:D362	9.8	No	No	0	0	4
13	L:L:F6	R:R:Y139	5.16	Yes	Yes	1	0	4
14	L:L:F6	R:R:V142	6.55	Yes	No	0	0	5
15	L:L:F6	R:R:Y146	8.25	Yes	Yes	1	0	8
16	L:L:F6	R:R:M370	4.98	Yes	No	0	0	6
17	L:L:F6	R:R:L374	4.87	Yes	No	1	0	7
18	L:L:T7	R:R:K195	12.01	No	Yes	0	0	7
19	L:L:D8	L:L:R12	17.87	No	No	0	0	0
20	L:L:D8	R:R:I289	8.4	No	No	0	0	8
21	L:L:S9	R:R:Y139	5.09	No	Yes	0	0	4
22	L:L:R14	L:L:Y10	9.26	No	No	1	0	0
23	L:L:Y10	R:R:Y139	5.96	No	Yes	1	0	4
24	L:L:Y10	R:R:F200	18.57	No	No	1	0	4
25	L:L:K15	L:L:S11	7.65	No	No	0	0	0
26	L:L:S11	R:R:D287	7.36	No	No	0	0	5
27	L:L:R12	R:R:T288	5.17	No	No	1	0	4
28	L:L:R12	R:R:N290	6.03	No	No	1	0	3
29	L:L:M17	L:L:Y13	11.97	No	Yes	0	0	0
30	L:L:Y13	R:R:Q135	11.27	Yes	No	1	0	3
31	L:L:Y13	R:R:T136	4.99	Yes	No	0	0	2
32	L:L:Y13	R:R:Y139	7.94	Yes	Yes	1	0	4
33	L:L:R14	R:R:F200	11.76	No	No	1	0	4
34	L:L:R14	R:R:E204	4.65	No	No	0	0	4
35	L:L:K15	R:R:C208	11.32	No	No	0	0	4
36	L:L:Q16	R:R:F93	3.51	No	Yes	0	0	4
37	L:L:A18	R:R:S205	3.42	No	No	0	0	1
38	L:L:V19	R:R:F93	5.24	No	Yes	0	0	4
39	L:L:K20	R:R:F93	12.41	No	Yes	7	0	4
40	L:L:K20	R:R:K127	7.18	No	Yes	7	0	3
41	L:L:L23	L:L:Y22	4.69	No	No	0	0	0
42	L:L:V26	L:L:Y22	5.05	No	No	0	0	0
43	L:L:Y22	R:R:V40	15.14	No	No	0	0	3
44	L:L:L23	R:R:I89	8.56	No	No	0	0	5
45	L:L:L23	R:R:F90	3.65	No	No	0	0	5
46	R:R:D38	R:R:E36	3.9	No	No	9	5	6
47	R:R:E36	R:R:Y39	4.49	No	Yes	9	6	4
48	R:R:C208	R:R:C37	5.46	No	No	0	4	6
49	R:R:D38	R:R:Y39	10.34	No	Yes	9	5	4
50	R:R:M42	R:R:Y39	4.79	No	Yes	0	4	4
51	R:R:I89	R:R:Y39	10.88	No	Yes	0	5	4
52	R:R:L92	R:R:Y39	8.21	No	Yes	0	4	4
53	R:R:E44	R:R:H47	6.15	No	No	0	5	4
54	R:R:C50	R:R:Q46	4.58	No	No	6	8	5
55	R:R:Q46	R:R:W67	3.29	No	Yes	6	5	6
56	R:R:C72	R:R:Q46	6.1	No	No	6	9	5
57	R:R:H47	R:R:W67	23.27	No	Yes	0	4	6
58	R:R:C50	R:R:W67	9.14	No	Yes	6	8	6
59	R:R:C50	R:R:C72	7.28	No	No	6	8	9
60	R:R:E52	R:R:E53	5.07	No	No	0	4	4
61	R:R:K65	R:R:L56	4.23	Yes	No	0	3	2
62	R:R:S64	R:R:T60	3.2	No	No	0	4	2
63	R:R:K65	R:R:T60	7.51	Yes	No	10	3	2
64	R:R:A75	R:R:T60	3.36	No	No	10	4	2
65	R:R:C105	R:R:G62	3.92	No	No	0	9	3
66	R:R:C105	R:R:C63	7.28	No	No	0	9	9
67	R:R:A75	R:R:K65	3.21	No	Yes	10	4	3
68	R:R:C72	R:R:W67	6.53	No	Yes	6	9	6
69	R:R:D68	R:R:L70	4.07	Yes	No	3	9	6
70	R:R:D68	R:R:T71	4.34	Yes	Yes	3	9	5
71	R:R:D68	R:R:L113	4.07	Yes	Yes	0	9	3
72	R:R:L70	R:R:T71	8.84	No	Yes	3	6	5
73	R:R:E114	R:R:L70	10.6	Yes	No	0	4	6
74	R:R:P87	R:R:T71	3.5	No	Yes	0	9	5
75	R:R:R103	R:R:T71	9.06	Yes	Yes	3	8	5
76	R:R:P74	R:R:W73	9.46	No	Yes	0	5	9
77	R:R:V82	R:R:W73	11.03	No	Yes	0	6	9
78	R:R:L84	R:R:W73	10.25	No	Yes	3	5	9
79	R:R:R103	R:R:W73	22.99	Yes	Yes	3	8	9
80	R:R:P77	R:R:T76	5.25	No	No	0	1	7
81	R:R:Q80	R:R:T76	8.5	No	No	0	4	7
82	R:R:S104	R:R:V81	8.08	No	No	0	4	4
83	R:R:L84	R:R:R103	4.86	No	Yes	3	5	8
84	R:R:C86	R:R:P87	3.77	No	No	0	9	9
85	R:R:C86	R:R:F90	4.19	No	No	8	9	5
86	R:R:C122	R:R:C86	7.28	Yes	No	8	9	9
87	R:R:K91	R:R:L88	5.64	No	No	0	3	3
88	R:R:C122	R:R:F90	5.59	Yes	No	8	9	5
89	R:R:K91	R:R:Q97	14.92	No	No	0	3	4
90	R:R:F93	R:R:L92	13.4	Yes	No	0	4	4
91	R:R:F93	R:R:K127	4.96	Yes	Yes	7	4	3
92	R:R:C122	R:R:S94	3.44	Yes	No	0	9	4
93	R:R:D126	R:R:S94	4.42	Yes	No	0	1	4
94	R:R:D126	R:R:S95	4.42	Yes	No	0	1	3
95	R:R:D126	R:R:I96	4.2	Yes	No	0	1	5
96	R:R:R99	R:R:Y118	11.32	No	Yes	11	4	7
97	R:R:P119	R:R:R99	12.97	Yes	No	11	5	4
98	R:R:E114	R:R:V101	5.7	Yes	No	0	4	6
99	R:R:P115	R:R:V101	3.53	No	No	0	5	6
100	R:R:P115	R:R:S102	7.13	No	No	0	5	5
101	R:R:L113	R:R:R103	12.15	Yes	Yes	0	3	8
102	R:R:H112	R:R:S104	8.37	No	No	0	2	4
103	R:R:H112	R:R:T106	6.85	No	No	0	2	4
104	R:R:L113	R:R:T106	5.9	Yes	No	0	3	4
105	R:R:D107	R:R:E108	6.5	No	No	0	1	5
106	R:R:G109	R:R:L113	3.42	No	Yes	0	9	3
107	R:R:E114	R:R:P119	4.72	Yes	Yes	0	4	5
108	R:R:E114	R:R:I120	10.93	Yes	No	0	4	6
109	R:R:G116	R:R:P117	4.06	No	No	0	8	6
110	R:R:P119	R:R:Y118	4.17	Yes	Yes	11	5	7
111	R:R:D125	R:R:Y118	8.05	No	Yes	0	2	7
112	R:R:D126	R:R:Y118	9.2	Yes	Yes	0	1	7
113	R:R:A121	R:R:D125	4.63	No	No	0	5	2
114	R:R:K127	R:R:L131	7.05	Yes	No	0	3	2
115	R:R:D132	R:R:K127	15.21	No	Yes	0	1	3
116	R:R:A128	R:R:L131	4.73	No	No	0	1	2
117	R:R:Q135	R:R:Y139	5.64	No	Yes	1	3	4
118	R:R:F138	R:R:Y139	6.19	Yes	Yes	0	5	4
119	R:R:F138	R:R:V142	6.55	Yes	No	0	5	5
120	R:R:K143	R:R:Y146	8.36	Yes	Yes	1	5	8
121	R:R:D196	R:R:K143	8.3	No	Yes	1	7	5
122	R:R:Y146	R:R:Y150	6.95	Yes	Yes	1	8	8
123	R:R:D196	R:R:Y146	10.34	No	Yes	1	7	8
124	R:R:L374	R:R:Y146	3.52	No	Yes	1	7	8
125	R:R:F193	R:R:T147	3.89	No	No	0	7	7
126	R:R:G149	R:R:S378	3.71	No	No	0	8	9
127	R:R:F379	R:R:G149	9.03	No	No	0	7	8
128	R:R:R188	R:R:Y150	9.26	Yes	Yes	1	8	8
129	R:R:A189	R:R:Y150	4	No	Yes	0	7	8
130	R:R:V192	R:R:Y150	10.09	No	Yes	0	7	8
131	R:R:S378	R:R:Y150	7.63	No	Yes	0	9	8
132	R:R:F382	R:R:L152	14.61	Yes	No	0	6	5
133	R:R:L154	R:R:L158	5.54	No	No	0	6	3
134	R:R:I186	R:R:L154	4.28	No	No	0	6	6
135	R:R:F382	R:R:T156	9.08	Yes	No	0	6	6
136	R:R:A385	R:R:T156	3.36	No	No	0	8	6
137	R:R:F390	R:R:T156	3.89	No	No	0	9	6
138	R:R:F182	R:R:L157	6.09	No	No	0	8	9
139	R:R:A385	R:R:L157	3.15	No	No	0	8	9
140	R:R:A160	R:R:C389	3.61	No	No	0	9	9
141	R:R:F182	R:R:T161	3.89	No	No	0	8	6
142	R:R:L164	R:R:N175	13.73	No	Yes	0	7	9
143	R:R:L164	R:R:M179	8.48	No	No	0	7	6
144	R:R:F167	R:R:L170	4.87	Yes	Yes	4	6	9
145	R:R:E398	R:R:F167	13.99	No	Yes	4	7	6
146	R:R:F167	R:R:L399	3.65	Yes	No	0	6	5
147	R:R:F167	R:R:K402	3.72	Yes	No	0	6	5
148	R:R:H171	R:R:R168	3.39	No	No	0	8	7
149	R:R:E398	R:R:K169	16.2	No	No	0	7	7
150	R:R:L170	R:R:N175	4.12	Yes	Yes	4	9	9
151	R:R:L170	R:R:V395	5.96	Yes	No	0	9	9
152	R:R:E398	R:R:L170	6.63	No	Yes	4	7	9
153	R:R:H171	R:R:Y176	9.8	No	No	0	8	6
154	R:R:C172	R:R:R174	5.57	No	Yes	4	8	9
155	R:R:C172	R:R:N175	6.3	No	Yes	4	8	9
156	R:R:T173	R:R:Y239	6.24	No	Yes	2	7	8
157	R:R:E251	R:R:T173	5.64	No	No	2	6	7
158	R:R:N175	R:R:R174	14.46	Yes	Yes	4	9	9
159	R:R:H178	R:R:R174	3.39	No	Yes	0	9	9
160	R:R:E394	R:R:R174	4.65	No	Yes	0	9	9
161	R:R:M179	R:R:Y176	3.59	No	No	0	6	6
162	R:R:F255	R:R:Y176	4.13	Yes	No	0	6	6
163	R:R:E236	R:R:I177	6.83	Yes	Yes	0	9	9
164	R:R:I177	R:R:Y239	4.84	Yes	Yes	2	9	8
165	R:R:F255	R:R:I177	5.02	Yes	Yes	0	6	9
166	R:R:I177	R:R:Y258	3.63	Yes	Yes	2	9	7
167	R:R:E236	R:R:H178	12.31	Yes	No	0	9	9
168	R:R:H178	R:R:Y388	4.36	No	No	0	9	8
169	R:R:H180	R:R:W232	13.75	No	Yes	12	9	9
170	R:R:H180	R:R:I259	6.63	No	No	0	9	4
171	R:R:H180	R:R:W263	6.35	No	No	12	9	8
172	R:R:F185	R:R:L181	6.09	Yes	No	0	8	9
173	R:R:E236	R:R:L181	14.58	Yes	No	0	9	9
174	R:R:F182	R:R:V384	3.93	No	No	0	8	9
175	R:R:N229	R:R:S184	7.45	No	No	0	8	9
176	R:R:S184	R:R:W232	7.41	No	Yes	0	9	9
177	R:R:F185	R:R:N229	18.12	Yes	No	0	8	8
178	R:R:F185	R:R:Q380	7.03	Yes	Yes	0	8	9
179	R:R:F185	R:R:G381	9.03	Yes	No	0	8	9
180	R:R:R188	R:R:V226	7.85	Yes	No	1	8	5
181	R:R:N229	R:R:R188	12.05	No	Yes	0	8	8
182	R:R:F230	R:R:R188	6.41	Yes	Yes	1	8	8
183	R:R:A191	R:R:F221	4.16	No	No	13	6	4
184	R:R:A191	R:R:C225	3.61	No	No	13	6	6
185	R:R:D196	R:R:K195	5.53	No	Yes	0	7	7
186	R:R:K195	R:R:L199	5.64	Yes	Yes	0	7	7
187	R:R:F222	R:R:K195	13.65	Yes	Yes	0	7	7
188	R:R:D201	R:R:L197	5.43	No	No	0	4	2
189	R:R:F200	R:R:L199	7.31	No	Yes	1	4	7
190	R:R:C215	R:R:L199	4.76	Yes	Yes	1	9	7
191	R:R:C285	R:R:L199	3.17	Yes	Yes	1	9	7
192	R:R:D287	R:R:L199	5.43	No	Yes	1	5	7
193	R:R:G203	R:R:Q207	4.93	No	No	0	4	4
194	R:R:C215	R:R:Q207	4.58	Yes	No	1	9	4
195	R:R:C285	R:R:Q207	4.58	Yes	No	1	9	4
196	R:R:C215	R:R:C285	7.28	Yes	Yes	1	9	9
197	R:R:D282	R:R:K216	6.91	No	No	1	6	8
198	R:R:K216	R:R:W286	30.17	No	Yes	1	8	9
199	R:R:F222	R:R:M219	4.98	Yes	No	1	7	5
200	R:R:M219	R:R:Q223	4.08	No	Yes	1	5	7
201	R:R:V220	R:R:W273	3.68	No	Yes	0	5	8
202	R:R:T274	R:R:V220	7.93	No	No	0	6	5
203	R:R:C225	R:R:F221	8.38	No	No	13	6	4
204	R:R:F222	R:R:Q223	8.2	Yes	Yes	1	7	7
205	R:R:F222	R:R:V226	3.93	Yes	No	1	7	5
206	R:R:Q223	R:R:W273	5.48	Yes	Yes	1	7	8
207	R:R:Q223	R:R:W294	6.57	Yes	Yes	1	7	7
208	R:R:I297	R:R:Q223	8.23	Yes	Yes	1	7	7
209	R:R:W263	R:R:Y224	5.79	No	No	0	8	9
210	R:R:T270	R:R:Y224	7.49	No	No	0	6	9
211	R:R:F231	R:R:M227	3.73	No	Yes	1	5	5
212	R:R:M227	R:R:P266	6.71	Yes	Yes	1	5	9
213	R:R:F269	R:R:M227	4.98	No	Yes	0	6	5
214	R:R:I297	R:R:M227	4.37	Yes	Yes	1	7	5
215	R:R:I301	R:R:M227	8.75	No	Yes	0	7	5
216	R:R:A228	R:R:P266	3.74	No	Yes	0	8	9
217	R:R:F230	R:R:I301	15.07	Yes	No	0	8	7
218	R:R:F230	R:R:I305	6.28	Yes	No	1	8	7
219	R:R:F230	R:R:Y354	16.5	Yes	Yes	1	8	8
220	R:R:F231	R:R:V265	5.24	No	No	1	5	5
221	R:R:F231	R:R:P266	10.11	No	Yes	1	5	9
222	R:R:V235	R:R:W232	7.36	No	Yes	0	7	9
223	R:R:G262	R:R:W232	8.44	No	Yes	0	9	9
224	R:R:W232	R:R:W263	24.37	Yes	No	12	9	8
225	R:R:L233	R:R:Q380	3.99	No	Yes	0	9	9
226	R:R:L234	R:R:L238	6.92	Yes	No	0	8	6
227	R:R:L234	R:R:S304	4.5	Yes	No	0	8	7
228	R:R:L234	R:R:N308	4.12	Yes	No	0	8	9
229	R:R:V235	R:R:Y258	3.79	No	Yes	0	7	7
230	R:R:E236	R:R:L349	5.3	Yes	No	0	9	9
231	R:R:F350	R:R:G237	6.02	Yes	No	0	9	9
232	R:R:L238	R:R:L311	4.15	No	No	0	6	8
233	R:R:L243	R:R:Y239	9.38	No	Yes	2	7	8
234	R:R:E251	R:R:Y239	8.98	No	Yes	2	6	8
235	R:R:Y239	R:R:Y258	3.97	Yes	Yes	2	8	7
236	R:R:L240	R:R:L244	4.15	No	No	0	9	8
237	R:R:I315	R:R:L240	4.28	No	No	0	9	9
238	R:R:F350	R:R:L240	4.87	Yes	No	0	9	9
239	R:R:A245	R:R:Y241	9.34	No	Yes	0	7	8
240	R:R:L311	R:R:Y241	5.86	No	Yes	0	8	8
241	R:R:C314	R:R:Y241	4.03	No	Yes	0	8	8
242	R:R:I315	R:R:Y241	3.63	No	Yes	0	9	8
243	R:R:T242	R:R:V246	3.17	No	No	2	7	4
244	R:R:F249	R:R:T242	9.08	No	No	2	5	7
245	R:R:T242	R:R:Y258	3.75	No	Yes	2	7	7
246	R:R:E251	R:R:L243	3.98	No	No	2	6	7
247	R:R:I318	R:R:L244	4.28	No	No	0	8	8
248	R:R:F249	R:R:V246	5.24	No	No	2	5	4
249	R:R:F248	R:R:S247	3.96	No	No	0	6	7
250	R:R:F249	R:R:Y254	9.28	No	No	0	5	4
251	R:R:K253	R:R:S250	6.12	No	No	0	4	7
252	R:R:F255	R:R:R252	3.21	Yes	No	0	6	5
253	R:R:K253	R:R:Y254	9.55	No	No	0	4	4
254	R:R:F255	R:R:I259	8.79	Yes	No	0	6	4
255	R:R:G257	R:R:W256	5.63	No	No	0	2	3
256	R:R:G264	R:R:S267	3.71	No	No	0	7	3
257	R:R:P266	R:R:V265	3.53	Yes	No	1	9	5
258	R:R:F269	R:R:P300	14.45	No	No	0	6	9
259	R:R:R277	R:R:W273	13	Yes	Yes	1	8	8
260	R:R:W273	R:R:W286	3.75	Yes	Yes	1	8	9
261	R:R:I296	R:R:W273	3.52	No	Yes	0	8	8
262	R:R:I297	R:R:W273	11.74	Yes	Yes	1	7	8
263	R:R:A276	R:R:L293	4.73	No	Yes	0	4	4
264	R:R:E281	R:R:R277	18.61	Yes	Yes	1	6	8
265	R:R:R277	R:R:W286	14.99	Yes	Yes	1	8	9
266	R:R:L293	R:R:R277	3.64	Yes	Yes	1	4	8
267	R:R:H279	R:R:I278	3.98	No	No	0	1	3
268	R:R:I278	R:R:W286	3.52	No	Yes	0	3	9
269	R:R:E281	R:R:N290	5.26	Yes	No	1	6	3
270	R:R:E281	R:R:S291	8.62	Yes	No	1	6	5
271	R:R:E281	R:R:L293	5.3	Yes	Yes	1	6	4
272	R:R:D282	R:R:W286	10.05	No	Yes	1	6	9
273	R:R:C285	R:R:D287	6.22	Yes	No	1	9	5
274	R:R:N290	R:R:T288	4.39	No	No	1	3	4
275	R:R:I289	R:R:W294	24.66	No	Yes	0	8	7
276	R:R:L293	R:R:S291	6.01	Yes	No	1	4	5
277	R:R:I297	R:R:W294	3.52	Yes	Yes	1	7	7
278	R:R:K298	R:R:W294	12.76	Yes	Yes	1	7	7
279	R:R:D362	R:R:W294	4.47	No	Yes	1	4	7
280	R:R:K298	R:R:W295	10.44	Yes	No	0	7	6
281	R:R:D362	R:R:K298	11.06	No	Yes	1	4	7
282	R:R:G299	R:R:P300	4.06	No	No	0	4	9
283	R:R:I305	R:R:Y354	4.84	No	Yes	1	7	8
284	R:R:F350	R:R:N308	6.04	Yes	No	0	9	9
285	R:R:F309	R:R:I313	5.02	No	No	0	5	5
286	R:R:F309	R:R:I355	12.56	No	No	0	5	5
287	R:R:F312	R:R:I316	8.79	Yes	No	5	9	7
288	R:R:F312	R:R:T343	3.89	Yes	No	5	9	9
289	R:R:F312	R:R:I347	5.02	Yes	No	5	9	8
290	R:R:F312	R:R:F350	3.22	Yes	Yes	0	9	9
291	R:R:F312	R:R:V352	9.18	Yes	No	5	9	6
292	R:R:I316	R:R:T343	6.08	No	No	5	7	9
293	R:R:L319	R:R:L339	4.15	No	No	0	8	8
294	R:R:L320	R:R:R324	7.29	No	No	0	5	6
295	R:R:L323	R:R:R338	4.86	No	No	0	8	8
296	R:R:R324	R:R:Y336	7.2	No	No	0	6	6
297	R:R:P325	R:R:P326	5.84	No	No	0	6	6
298	R:R:K330	R:R:P326	3.35	No	No	0	4	6
299	R:R:D327	R:R:R329	5.96	No	No	0	6	3
300	R:R:K330	R:R:R329	14.85	No	No	0	4	3
301	R:R:S333	R:R:S334	3.26	No	No	0	6	5
302	R:R:S334	R:R:S337	4.89	No	No	0	5	6
303	R:R:R338	R:R:R341	8.53	No	No	0	8	8
304	R:R:R338	R:R:S342	3.95	No	No	0	8	9
305	R:R:L345	R:R:R341	7.29	No	No	0	8	8
306	R:R:F350	R:R:L346	9.74	Yes	No	0	9	9
307	R:R:I347	R:R:P348	3.39	No	No	0	8	9
308	R:R:I347	R:R:V352	4.61	No	No	5	8	6
309	R:R:P348	R:R:V383	3.53	No	No	0	9	5
310	R:R:F350	R:R:L349	7.31	Yes	No	0	9	9
311	R:R:L349	R:R:Y388	19.93	No	No	0	9	8
312	R:R:G351	R:R:H353	3.18	No	Yes	1	9	8
313	R:R:G351	R:R:Q380	3.29	No	Yes	1	9	9
314	R:R:H353	R:R:Y354	14.16	Yes	Yes	1	8	8
315	R:R:F372	R:R:H353	3.39	No	Yes	0	4	8
316	R:R:H353	R:R:Q380	11.13	Yes	Yes	1	8	9
317	R:R:E373	R:R:Y354	6.73	No	Yes	0	7	8
318	R:R:Q380	R:R:Y354	3.38	Yes	Yes	1	9	8
319	R:R:F372	R:R:M356	4.98	No	No	0	4	6
320	R:R:F357	R:R:F360	9.65	No	No	0	6	5
321	R:R:F357	R:R:K369	9.93	No	No	0	6	8
322	R:R:F357	R:R:F372	7.5	No	No	0	6	4
323	R:R:F360	R:R:F364	10.72	No	No	0	5	3
324	R:R:F364	R:R:P361	7.22	No	No	0	3	8
325	R:R:F364	R:R:K365	11.17	No	No	0	3	2
326	R:R:E367	R:R:P366	6.29	No	No	0	3	5
327	R:R:E373	R:R:K369	10.8	No	No	0	7	8
328	R:R:G381	R:R:V384	3.68	No	No	0	9	9
329	R:R:F382	R:R:I386	3.77	Yes	No	0	6	5
330	R:R:I386	R:R:L391	4.28	No	No	0	5	6
331	R:R:C389	R:R:F390	5.59	No	No	0	9	9
332	R:R:N392	R:R:V395	7.39	No	No	0	9	9
333	R:R:R400	R:R:R404	3.2	No	No	0	5	3
334	R:R:F193	R:R:Y150	3.09	No	Yes	0	7	8
335	R:R:I296	R:R:V272	3.07	No	No	0	8	4
336	R:R:I148	R:R:T144	3.04	No	No	0	5	4
337	R:R:I183	R:R:T161	3.04	No	No	0	3	6
338	R:R:K365	R:R:V368	3.04	No	No	0	2	4
339	R:R:F193	R:R:G151	3.01	No	No	0	7	6
340	R:R:L319	R:R:S342	3	No	No	0	8	9
341	L:L:L27	L:L:V26	2.98	No	No	0	0	0
342	R:R:L234	R:R:V307	2.98	Yes	No	0	8	6
343	R:R:L311	R:R:V307	2.98	No	No	0	8	6
344	R:R:L387	R:R:V383	2.98	No	No	0	8	5
345	R:R:I305	R:R:I355	2.94	No	No	0	7	5
346	R:R:E210	R:R:S212	2.87	No	No	0	4	3
347	R:R:I186	R:R:L157	2.85	No	No	0	6	9
348	R:R:I183	R:R:L187	2.85	No	No	0	3	6
349	L:L:K20	R:R:L124	2.82	No	No	0	0	3
350	R:R:K298	R:R:L302	2.82	Yes	No	0	7	4
351	R:R:P335	R:R:Y336	2.78	No	No	0	7	6
352	R:R:A358	R:R:F359	2.77	No	No	0	6	5
353	R:R:K48	R:R:Q49	2.71	No	No	0	3	4
354	R:R:D68	R:R:N69	2.69	Yes	No	0	9	4
355	R:R:L131	R:R:Q135	2.66	No	No	0	2	3
356	R:R:H279	R:R:I275	2.65	No	No	0	1	4
357	R:R:F382	R:R:S153	2.64	Yes	No	0	6	9
358	R:R:F138	R:R:V371	2.62	Yes	No	0	5	5
359	R:R:F390	R:R:V159	2.62	No	No	0	9	5
360	R:R:D38	R:R:Q41	2.61	No	No	0	5	4
361	R:R:S267	R:R:Y224	2.54	No	No	0	3	9
362	R:R:F167	R:R:I163	2.51	Yes	No	0	6	8
363	R:R:F221	R:R:I194	2.51	No	No	0	4	5
364	R:R:F359	R:R:I355	2.51	No	No	0	5	5
365	R:R:F359	R:R:L306	2.44	No	No	0	5	3
366	R:R:I43	R:R:W67	2.35	No	Yes	0	6	6
367	R:R:L339	R:R:Y336	2.34	No	No	0	8	6
368	R:R:L345	R:R:Y388	2.34	No	No	0	8	8
369	R:R:E367	R:R:F138	2.33	No	Yes	0	3	5
370	R:R:F280	R:R:H279	2.26	No	No	0	3	1
371	R:R:R401	R:R:R404	2.13	No	No	0	7	3
372	R:R:G116	R:R:P119	2.03	No	Yes	0	8	5
373	R:R:C122	R:R:G123	1.96	Yes	No	0	9	3
374	R:R:A217	R:R:G214	1.95	No	No	0	4	3
375	R:R:W256	R:R:Y254	1.93	No	No	0	3	4
376	R:R:G214	R:R:S212	1.86	No	No	0	3	3
377	R:R:G145	R:R:V375	1.84	No	No	0	6	5
378	R:R:G116	R:R:T111	1.82	No	No	0	8	4
379	R:R:G145	R:R:T144	1.82	No	No	0	6	4
380	R:R:A198	R:R:A218	1.79	No	No	0	4	5
381	R:R:P335	R:R:S334	1.78	No	No	0	7	5
382	R:R:G62	R:R:I61	1.76	No	No	0	3	1
383	R:R:G149	R:R:I148	1.76	No	No	0	8	5
384	R:R:G262	R:R:I261	1.76	No	No	0	9	6
385	R:R:P300	R:R:T303	1.75	No	No	0	9	3
386	R:R:G140	R:R:K143	1.74	No	Yes	0	3	5
387	R:R:G211	R:R:K216	1.74	No	No	0	5	8
388	R:R:C215	R:R:S212	1.72	Yes	No	0	9	3
389	R:R:A128	R:R:S130	1.71	No	No	0	1	1
390	R:R:G257	R:R:L260	1.71	No	No	0	2	3
391	R:R:C63	R:R:T76	1.69	No	No	0	9	7
392	R:R:G98	R:R:Q97	1.64	No	No	0	3	4
393	R:R:C314	R:R:I310	1.64	No	No	0	8	3
394	R:R:N363	R:R:P361	1.63	No	No	0	4	8
395	R:R:S141	R:R:V142	1.62	No	No	0	4	5
396	R:R:A218	R:R:I194	1.62	No	No	0	5	5
397	R:R:A54	R:R:K65	1.61	No	Yes	0	2	3
398	R:R:S267	R:R:T268	1.6	No	No	0	3	4
399	R:R:C225	R:R:L187	1.59	No	No	0	6	6
400	R:R:G377	R:R:H353	1.59	No	Yes	0	6	8
401	L:L:A24	R:R:L124	1.58	No	No	0	0	3
402	R:R:K91	R:R:S94	1.53	No	No	0	3	4
403	R:R:M179	R:R:S165	1.53	No	No	0	6	3
404	R:R:G79	R:R:R78	1.5	No	No	0	7	5
405	R:R:N100	R:R:V83	1.48	No	No	0	3	3
406	R:R:I43	R:R:I89	1.47	No	No	0	6	5
407	R:R:D206	R:R:S205	1.47	No	No	0	1	1
408	R:R:D332	R:R:S337	1.47	No	No	0	7	6
409	R:R:I318	R:R:K322	1.45	No	No	0	8	9
410	R:R:E133	R:R:S130	1.44	No	No	0	2	1
411	R:R:E204	R:R:S205	1.44	No	No	0	4	1
412	R:R:P325	R:R:R324	1.44	No	No	0	6	6
413	R:R:Q49	R:R:V45	1.43	No	No	0	4	3
414	R:R:G109	R:R:W110	1.41	No	No	0	9	9
415	R:R:D107	R:R:M66	1.39	No	No	0	1	5
416	R:R:D201	R:R:K143	1.38	No	Yes	0	4	5
417	R:R:K322	R:R:Q321	1.36	No	No	0	9	7
418	R:R:E59	R:R:N58	1.31	No	No	0	3	1
419	R:R:H47	R:R:L51	1.29	No	No	0	4	3
420	R:R:E133	R:R:Q134	1.27	No	No	0	2	1
421	R:R:I61	R:R:R78	1.25	No	No	0	1	5
422	R:R:K169	R:R:R401	1.24	No	No	0	7	7
423	R:R:S292	R:R:W295	1.24	No	No	0	3	6
424	R:R:E281	R:R:Y283	1.12	Yes	No	0	6	3
425	R:R:R404	R:R:W403	1	No	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	7.42	5	1	0
2	L:L:D3	5.4775	4	1	0
3	L:L:F6	5.962	5	1	0
4	L:L:Y13	9.0425	4	1	0
5	R:R:Y39	7.742	5	9	4
6	R:R:K65	4.14	4	10	3
7	R:R:W67	8.916	5	6	6
8	R:R:D68	3.7925	4	3	9
9	R:R:T71	6.435	4	3	5
10	R:R:W73	13.4325	4	3	9
11	R:R:F93	7.904	5	7	4
12	R:R:R103	12.265	4	3	8
13	R:R:L113	6.385	4	0	3
14	R:R:E114	7.9875	4	0	4
15	R:R:Y118	8.185	4	11	7
16	R:R:P119	5.9725	4	11	5
17	R:R:C122	4.5675	4	8	9
18	R:R:D126	5.56	4	0	1
19	R:R:K127	8.6	4	7	3
20	R:R:F138	4.4225	4	0	5
21	R:R:Y139	5.99667	6	1	4
22	R:R:K143	4.945	4	1	5
23	R:R:Y146	7.484	5	1	8
24	R:R:Y150	6.68143	7	1	8
25	R:R:F167	5.748	5	4	6
26	R:R:L170	5.395	4	4	9
27	R:R:R174	7.0175	4	4	9
28	R:R:N175	9.6525	4	4	9
29	R:R:I177	5.08	4	2	9
30	R:R:F185	10.0675	4	0	8
31	R:R:R188	8.066	5	1	8
32	R:R:K195	9.2075	4	0	7
33	R:R:L199	5.262	5	1	7
34	R:R:C215	4.585	4	1	9
35	R:R:F222	6.87667	6	1	7
36	R:R:Q223	6.66333	6	1	7
37	R:R:M227	5.708	5	1	5
38	R:R:F230	11.065	4	1	8
39	R:R:W232	12.266	5	12	9
40	R:R:L234	4.63	4	0	8
41	R:R:E236	9.755	4	0	9
42	R:R:Y239	6.682	5	2	8
43	R:R:Y241	5.715	4	0	8
44	R:R:F255	5.2875	4	0	6
45	R:R:Y258	3.785	4	2	7
46	R:R:P266	6.0225	4	1	9
47	R:R:W273	6.86167	6	1	8
48	R:R:R277	12.56	4	1	8
49	R:R:E281	7.782	5	1	6
50	R:R:C285	5.3125	4	1	9
51	R:R:W286	12.496	5	1	9
52	R:R:L293	4.92	4	1	4
53	R:R:W294	10.25	6	1	7
54	R:R:I297	6.965	4	1	7
55	R:R:K298	9.27	4	1	7
56	R:R:F312	6.02	5	5	9
57	R:R:F350	6.2	6	0	9
58	R:R:H353	6.69	5	1	8
59	R:R:Y354	9.122	5	1	8
60	R:R:Q380	5.764	5	1	9
61	R:R:F382	7.525	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:V226	11.2275	12.45	Yes	No	1	0	5
2	R:R:R188	R:R:V226	25.9426	7.85	Yes	No	1	8	5
3	R:R:F230	R:R:R188	23.1768	6.41	Yes	Yes	1	8	8
4	R:R:F230	R:R:Y354	16.5798	16.5	Yes	Yes	1	8	8
5	L:L:D3	R:R:F222	25.1721	5.97	Yes	Yes	1	0	7
6	R:R:R188	R:R:Y150	41.5543	9.26	Yes	Yes	1	8	8
7	L:L:D3	R:R:L374	44.9964	5.43	Yes	No	1	0	7
8	L:L:F6	R:R:Y146	38.6289	8.25	Yes	Yes	1	0	8
9	L:L:F6	R:R:L374	44.6028	4.87	Yes	No	1	0	7
10	L:L:F6	R:R:Y139	77.4889	5.16	Yes	Yes	1	0	4
11	R:R:K195	R:R:L199	17.5402	5.64	Yes	Yes	0	7	7
12	R:R:Q223	R:R:W273	21.6419	5.48	Yes	Yes	1	7	8
13	R:R:Q135	R:R:Y139	70.4877	5.64	No	Yes	1	3	4
14	R:R:L131	R:R:Q135	70.1366	2.66	No	No	0	2	3
15	R:R:K127	R:R:L131	66.4438	7.05	Yes	No	0	3	2
16	R:R:F93	R:R:K127	62.3467	4.96	Yes	Yes	7	4	3
17	R:R:F93	R:R:L92	60.3772	13.4	Yes	No	0	4	4
18	R:R:L92	R:R:Y39	59.6052	8.21	No	Yes	0	4	4
19	R:R:I89	R:R:Y39	55.6996	10.88	No	Yes	0	5	4
20	L:L:L23	R:R:I89	48.4628	8.56	No	No	0	0	5
21	L:L:L23	R:R:F90	44.3521	3.65	No	No	0	0	5
22	R:R:C86	R:R:F90	27.1918	4.19	No	No	8	9	5
23	R:R:C86	R:R:P87	26.6416	3.77	No	No	0	9	9
24	R:R:P87	R:R:T71	25.7633	3.5	No	Yes	0	9	5
25	R:R:R103	R:R:T71	11.229	9.06	Yes	Yes	3	8	5
26	R:R:C122	R:R:F90	16.329	5.59	Yes	No	8	9	5
27	R:R:C122	R:R:S94	14.8215	3.44	Yes	No	0	9	4
28	R:R:D126	R:R:S94	10.2093	4.42	Yes	No	0	1	4
29	R:R:N229	R:R:R188	100	12.05	No	Yes	0	8	8
30	R:R:F185	R:R:N229	80.4751	18.12	Yes	No	0	8	8
31	R:R:F185	R:R:G381	22.73	9.03	Yes	No	0	8	9
32	R:R:G381	R:R:V384	21.9276	3.68	No	No	0	9	9
33	R:R:F182	R:R:V384	21.1221	3.93	No	No	0	8	9
34	R:R:F182	R:R:L157	12.9006	6.09	No	No	0	8	9
35	R:R:F185	R:R:L181	73.135	6.09	Yes	No	0	8	9
36	R:R:E236	R:R:L181	72.6092	14.58	Yes	No	0	9	9
37	R:R:E236	R:R:H178	30.3421	12.31	Yes	No	0	9	9
38	R:R:H178	R:R:R174	15.3048	3.39	No	Yes	0	9	9
39	R:R:N175	R:R:R174	12.7623	14.46	Yes	Yes	4	9	9
40	R:R:N229	R:R:S184	21.3303	7.45	No	No	0	8	9
41	R:R:S184	R:R:W232	20.5705	7.41	No	Yes	0	9	9
42	R:R:E236	R:R:I177	14.086	6.83	Yes	Yes	0	9	9
43	R:R:L170	R:R:N175	11.4296	4.12	Yes	Yes	4	9	9
44	R:R:V235	R:R:W232	10.3749	7.36	No	Yes	0	7	9
45	R:R:H178	R:R:Y388	17.2606	4.36	No	No	0	9	8
46	R:R:E236	R:R:L349	39.1608	5.3	Yes	No	0	9	9
47	R:R:L349	R:R:Y388	17.5463	19.93	No	No	0	9	8
48	R:R:I301	R:R:M227	10.8475	8.75	No	Yes	0	7	5
49	R:R:F230	R:R:I301	11.6773	15.07	Yes	No	0	8	7
50	R:R:F350	R:R:L349	24.4563	7.31	Yes	No	0	9	9
51	R:R:L345	R:R:Y388	31.5396	2.34	No	No	0	8	8
52	R:R:L345	R:R:R341	29.9986	7.29	No	No	0	8	8
53	R:R:R338	R:R:R341	28.447	8.53	No	No	0	8	8
54	R:R:R338	R:R:S342	25.3347	3.95	No	No	0	8	9
55	R:R:L319	R:R:S342	23.774	3	No	No	0	8	9
56	R:R:L319	R:R:L339	22.2102	4.15	No	No	0	8	8
57	R:R:L339	R:R:Y336	20.6434	2.34	No	No	0	8	6
58	R:R:R324	R:R:Y336	11.1788	7.2	No	No	0	6	6
59	R:R:Y146	R:R:Y150	39.7018	6.95	Yes	Yes	1	8	8
60	R:R:F222	R:R:K195	18.3487	13.65	Yes	Yes	0	7	7
61	R:R:F222	R:R:Q223	21.9412	8.2	Yes	Yes	1	7	7
62	L:L:D3	R:R:R188	49.8123	4.76	Yes	Yes	1	0	8
63	R:R:F222	R:R:V226	14.393	3.93	Yes	No	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:F222	4.53	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:Q223	7.42	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:V226	12.45	1	Yes	No	0	5	0	1
L:L:H1	R:R:W294	9.52	1	Yes	Yes	0	7	0	1
L:L:S2	R:R:E373	11.5	0	No	No	0	7	0	1
L:L:D3	R:R:Y150	5.75	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:R188	4.76	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:F222	5.97	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:L374	5.43	1	Yes	No	0	7	0	1
L:L:I5	R:R:D362	9.8	0	No	No	0	4	0	1
L:L:F6	R:R:Y139	5.16	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:V142	6.55	1	Yes	No	0	5	0	1
L:L:F6	R:R:Y146	8.25	1	Yes	Yes	0	8	0	1
L:L:F6	R:R:M370	4.98	1	Yes	No	0	6	0	1
L:L:F6	R:R:L374	4.87	1	Yes	No	0	7	0	1
L:L:T7	R:R:K195	12.01	0	No	Yes	0	7	0	1
L:L:D8	R:R:I289	8.4	0	No	No	0	8	0	1
L:L:S9	R:R:Y139	5.09	0	No	Yes	0	4	0	1
L:L:Y10	R:R:Y139	5.96	1	No	Yes	0	4	0	1
L:L:Y10	R:R:F200	18.57	1	No	No	0	4	0	1
L:L:S11	R:R:D287	7.36	0	No	No	0	5	0	1
L:L:R12	R:R:T288	5.17	1	No	No	0	4	0	1
L:L:R12	R:R:N290	6.03	1	No	No	0	3	0	1
L:L:Y13	R:R:Q135	11.27	1	Yes	No	0	3	0	1
L:L:Y13	R:R:T136	4.99	1	Yes	No	0	2	0	1
L:L:Y13	R:R:Y139	7.94	1	Yes	Yes	0	4	0	1
L:L:R14	R:R:F200	11.76	1	No	No	0	4	0	1
L:L:R14	R:R:E204	4.65	1	No	No	0	4	0	1
L:L:K15	R:R:C208	11.32	0	No	No	0	4	0	1
L:L:Q16	R:R:F93	3.51	0	No	Yes	0	4	0	1
L:L:A18	R:R:S205	3.42	0	No	No	0	1	0	1
L:L:V19	R:R:F93	5.24	0	No	Yes	0	4	0	1
L:L:K20	R:R:F93	12.41	7	No	Yes	0	4	0	1
L:L:K20	R:R:K127	7.18	7	No	Yes	0	3	0	1
L:L:Y22	R:R:V40	15.14	0	No	No	0	3	0	1
L:L:L23	R:R:I89	8.56	0	No	No	0	5	0	1
L:L:L23	R:R:F90	3.65	0	No	No	0	5	0	1
R:R:C208	R:R:C37	5.46	0	No	No	4	6	1	2
R:R:I89	R:R:Y39	10.88	0	No	Yes	5	4	1	2
R:R:L92	R:R:Y39	8.21	0	No	Yes	4	4	2	2
R:R:C86	R:R:F90	4.19	8	No	No	9	5	2	1
R:R:C122	R:R:C86	7.28	8	Yes	No	9	9	2	2
R:R:C122	R:R:F90	5.59	8	Yes	No	9	5	2	1
R:R:F93	R:R:L92	13.4	7	Yes	No	4	4	1	2
R:R:F93	R:R:K127	4.96	7	Yes	Yes	4	3	1	1
R:R:K127	R:R:L131	7.05	7	Yes	No	3	2	1	2
R:R:D132	R:R:K127	15.21	0	No	Yes	1	3	2	1
R:R:Q135	R:R:Y139	5.64	1	No	Yes	3	4	1	1
R:R:F138	R:R:Y139	6.19	0	Yes	Yes	5	4	2	1
R:R:F138	R:R:V142	6.55	0	Yes	No	5	5	2	1
R:R:K143	R:R:Y146	8.36	1	Yes	Yes	5	8	2	1
R:R:D196	R:R:K143	8.3	1	No	Yes	7	5	2	2
R:R:Y146	R:R:Y150	6.95	1	Yes	Yes	8	8	1	1
R:R:D196	R:R:Y146	10.34	1	No	Yes	7	8	2	1
R:R:L374	R:R:Y146	3.52	1	No	Yes	7	8	1	1
R:R:R188	R:R:Y150	9.26	1	Yes	Yes	8	8	1	1
R:R:A189	R:R:Y150	4	0	No	Yes	7	8	2	1
R:R:V192	R:R:Y150	10.09	0	No	Yes	7	8	2	1
R:R:S378	R:R:Y150	7.63	0	No	Yes	9	8	2	1
R:R:R188	R:R:V226	7.85	1	Yes	No	8	5	1	1
R:R:N229	R:R:R188	12.05	0	No	Yes	8	8	2	1
R:R:F230	R:R:R188	6.41	1	Yes	Yes	8	8	2	1
R:R:D196	R:R:K195	5.53	1	No	Yes	7	7	2	1
R:R:K195	R:R:L199	5.64	0	Yes	Yes	7	7	1	2
R:R:F222	R:R:K195	13.65	1	Yes	Yes	7	7	1	1
R:R:F200	R:R:L199	7.31	1	No	Yes	4	7	1	2
R:R:C285	R:R:L199	3.17	1	Yes	Yes	9	7	2	2
R:R:D287	R:R:L199	5.43	1	No	Yes	5	7	1	2
R:R:F222	R:R:M219	4.98	1	Yes	No	7	5	1	2
R:R:M219	R:R:Q223	4.08	1	No	Yes	5	7	2	1
R:R:F222	R:R:Q223	8.2	1	Yes	Yes	7	7	1	1
R:R:F222	R:R:V226	3.93	1	Yes	No	7	5	1	1
R:R:Q223	R:R:W273	5.48	1	Yes	Yes	7	8	1	2
R:R:Q223	R:R:W294	6.57	1	Yes	Yes	7	7	1	1
R:R:I297	R:R:Q223	8.23	1	Yes	Yes	7	7	2	1
R:R:F230	R:R:Y354	16.5	1	Yes	Yes	8	8	2	2
R:R:I297	R:R:W273	11.74	1	Yes	Yes	7	8	2	2
R:R:E281	R:R:N290	5.26	1	Yes	No	6	3	2	1
R:R:C285	R:R:D287	6.22	1	Yes	No	9	5	2	1
R:R:N290	R:R:T288	4.39	1	No	No	3	4	1	1
R:R:I289	R:R:W294	24.66	0	No	Yes	8	7	1	1
R:R:I297	R:R:W294	3.52	1	Yes	Yes	7	7	2	1
R:R:K298	R:R:W294	12.76	1	Yes	Yes	7	7	2	1
R:R:D362	R:R:W294	4.47	1	No	Yes	4	7	1	1
R:R:D362	R:R:K298	11.06	1	No	Yes	4	7	1	2
R:R:E373	R:R:Y354	6.73	0	No	Yes	7	8	1	2
R:R:E373	R:R:K369	10.8	0	No	No	7	8	1	2
R:R:F193	R:R:Y150	3.09	0	No	Yes	7	8	2	1
L:L:K20	R:R:L124	2.82	7	No	No	0	3	0	1
R:R:L131	R:R:Q135	2.66	0	No	No	2	3	2	1
R:R:S141	R:R:V142	1.62	0	No	No	4	5	2	1
L:L:A24	R:R:L124	1.58	0	No	No	0	3	0	1
R:R:I43	R:R:I89	1.47	0	No	No	6	5	2	1
R:R:D206	R:R:S205	1.47	0	No	No	1	1	2	1
R:R:E204	R:R:S205	1.44	0	No	No	4	1	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E3Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	371
Number of Links	425
Number of Hubs	61
Number of Links mediated by Hubs	220
Number of Communities	13
Number of Nodes involved in Communities	100
Number of Links involved in Communities	134

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	119539
Length Of Smallest Path	3
Average Path Length	17.0421
Length of Longest Path	42
Minimum Path Strength	1.355
Average Path Strength	7.34498
Maximum Path Strength	22.58
Minimum Path Correlation	0.7
Average Path Correlation	0.963552
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	60.4553
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6706
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • signaling receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • multicellular organismal process • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of chemokine (C-C motif) ligand 5 production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell cycle • cell cycle • regulation of cell cycle • cell-cell signaling • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of G protein-coupled receptor signaling pathway • regulation of localization • localization • regulation of protein localization • macromolecule localization • intracellular protein localization • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • export from cell • establishment of localization • regulation of secretion • peptide transport • positive regulation of growth hormone secretion • positive regulation of transport • peptide hormone secretion • hormone transport • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • establishment of protein localization • protein localization to extracellular region • establishment of protein localization to extracellular region • protein secretion • protein transport • insulin secretion • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • cellular component organization or biogenesis • system development • somatodendritic compartment • cell body • perikaryon • neuronal cell body • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular region • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • regulation of establishment of protein localization • regulation of protein transport • regulation of protein secretion • regulation of insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32241
Sequence	>8E3Y_nogp_Chain_R E C D Y V Q M I E V Q H K Q C L E E A Q L E N E T I G C S K M W D N L T C W P A T P R G Q V V V L A C P L I F K L F S S I Q G R N V S R S C T D E G W T H L E P G P Y P I A C G L D D K A A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F R K L H C T R N Y I H M H L F I S F I L R A A A V F I K D L A L F D S G E S D Q C S E G S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S F F S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E D Y G C W D T I N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L R P P D I R K S D S S P Y S R L A R S T L L L I P L F G V H Y I M F A F F P D N F K P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E V Q A E L R R K W R R W H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6VN7	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.2	2020-09-02	doi.org/10.1038/s41467-020-17933-8
	6VN7 (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP	-		3.2	2020-09-02	doi.org/10.1038/s41467-020-17933-8
	8E3Y	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Y (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Z	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	2.7	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Z (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-		2.7	2022-11-23	doi.org/10.1038/s41467-022-34629-3

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