psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:H1	8.82	Yes	Yes	1	0	0
2	L:L:A4	L:L:H1	7.32	No	Yes	1	0	0
3	L:L:H1	R:R:Q223	8.65	Yes	No	1	0	7
4	L:L:H1	R:R:V226	12.45	Yes	No	0	0	5
5	L:L:H1	R:R:W294	5.29	Yes	Yes	1	0	7
6	L:L:S2	R:R:M370	3.07	No	Yes	0	0	6
7	L:L:S2	R:R:E373	4.31	No	No	0	0	7
8	L:L:S2	R:R:L374	9.01	No	Yes	0	0	7
9	L:L:D3	R:R:Y150	5.75	Yes	Yes	1	0	8
10	L:L:D3	R:R:R188	5.96	Yes	Yes	1	0	8
11	L:L:D3	R:R:F222	4.78	Yes	Yes	0	0	7
12	L:L:D3	R:R:L374	4.07	Yes	Yes	1	0	7
13	L:L:A4	R:R:W294	3.89	No	Yes	1	0	7
14	L:L:V5	R:R:I289	3.07	No	No	0	0	8
15	L:L:V5	R:R:K365	3.04	No	No	0	0	2
16	L:L:V5	R:R:M370	3.04	No	Yes	0	0	6
17	L:L:F6	R:R:Y139	4.13	Yes	Yes	1	0	4
18	L:L:F6	R:R:Y146	11.35	Yes	Yes	1	0	8
19	L:L:F6	R:R:M370	3.73	Yes	Yes	1	0	6
20	L:L:F6	R:R:L374	4.87	Yes	Yes	1	0	7
21	L:L:T7	R:R:K195	12.01	No	Yes	0	0	7
22	L:L:T7	R:R:F200	7.78	No	Yes	0	0	4
23	L:L:D8	L:L:R12	15.48	No	No	0	0	0
24	L:L:D8	R:R:I289	7	No	No	0	0	8
25	L:L:N9	R:R:Y139	5.81	No	Yes	0	0	4
26	L:L:R14	L:L:Y10	10.29	No	Yes	1	0	0
27	L:L:Y10	R:R:Y139	4.96	Yes	Yes	1	0	4
28	L:L:Y10	R:R:F200	16.5	Yes	Yes	1	0	4
29	L:L:K15	L:L:T11	3	No	No	0	0	0
30	L:L:T11	R:R:D287	10.12	No	No	0	0	5
31	L:L:R12	R:R:T288	5.17	No	Yes	0	0	4
32	L:L:L13	R:R:T136	2.95	No	No	0	0	2
33	L:L:R14	R:R:F200	3.21	No	Yes	1	0	4
34	L:L:R14	R:R:E204	12.79	No	No	0	0	4
35	L:L:K15	R:R:C37	8.08	No	No	0	0	6
36	L:L:M17	L:L:Q16	5.44	No	Yes	5	0	0
37	L:L:Q16	R:R:E36	6.37	Yes	No	0	0	6
38	L:L:Q16	R:R:F93	3.51	Yes	No	0	0	4
39	L:L:Q16	R:R:D132	3.92	Yes	No	5	0	1
40	L:L:M17	R:R:D132	6.93	No	No	5	0	1
41	L:L:A18	R:R:E204	3.02	No	No	0	0	4
42	L:L:K20	R:R:F93	3.72	No	No	0	0	4
43	L:L:Y22	R:R:V40	5.05	No	No	0	0	3
44	L:L:L23	R:R:F90	6.09	No	Yes	0	0	5
45	L:L:N24	R:R:D126	5.39	No	No	0	0	1
46	L:L:I26	L:L:S25	4.64	No	No	0	0	0
47	L:L:I26	R:R:N69	5.66	No	No	0	0	4
48	L:L:N28	R:R:N69	8.17	No	No	0	0	4
49	R:R:E36	R:R:L92	15.9	No	No	0	6	4
50	R:R:C208	R:R:C37	7.28	No	No	0	4	6
51	R:R:D38	R:R:Y39	12.64	No	No	0	5	4
52	R:R:L92	R:R:Y39	4.69	No	No	0	4	4
53	R:R:Q41	R:R:V40	4.3	No	No	0	4	3
54	R:R:I43	R:R:W67	4.7	No	Yes	0	6	6
55	R:R:I43	R:R:I89	2.94	No	No	0	6	5
56	R:R:Q46	R:R:W67	17.52	No	Yes	0	5	6
57	R:R:H47	R:R:W67	8.46	No	Yes	0	4	6
58	R:R:C50	R:R:C72	7.28	No	No	0	8	9
59	R:R:E53	R:R:Q55	3.82	No	No	0	4	1
60	R:R:K65	R:R:Q55	8.14	No	No	0	3	1
61	R:R:L56	R:R:S64	3	No	No	0	2	4
62	R:R:E59	R:R:G62	3.27	No	No	0	3	3
63	R:R:E59	R:R:T76	4.23	No	Yes	0	3	7
64	R:R:C63	R:R:I61	3.27	No	No	0	9	1
65	R:R:I61	R:R:T106	3.04	No	No	0	1	4
66	R:R:C105	R:R:C63	7.28	No	No	0	9	9
67	R:R:K65	R:R:S64	3.06	No	No	0	3	4
68	R:R:C72	R:R:W67	7.84	No	Yes	0	9	6
69	R:R:D68	R:R:W110	14.52	No	Yes	0	9	9
70	R:R:L70	R:R:N69	4.12	No	No	0	6	4
71	R:R:L70	R:R:T71	2.95	No	Yes	0	6	5
72	R:R:I120	R:R:L70	2.85	No	No	0	6	6
73	R:R:P87	R:R:T71	3.5	No	Yes	0	9	5
74	R:R:R103	R:R:T71	12.94	Yes	Yes	3	8	5
75	R:R:T71	R:R:W110	12.13	Yes	Yes	3	5	9
76	R:R:T76	R:R:W73	6.06	Yes	Yes	3	7	9
77	R:R:R103	R:R:W73	3	Yes	Yes	3	8	9
78	R:R:C105	R:R:W73	5.22	No	Yes	3	9	9
79	R:R:W110	R:R:W73	16.87	Yes	Yes	3	9	9
80	R:R:P77	R:R:T76	3.5	No	Yes	0	1	7
81	R:R:C105	R:R:T76	8.45	No	Yes	3	9	7
82	R:R:G79	R:R:Q80	3.29	No	No	0	7	4
83	R:R:S102	R:R:V81	4.85	No	No	0	5	4
84	R:R:L84	R:R:V82	2.98	No	No	0	5	6
85	R:R:S102	R:R:V83	3.23	No	No	0	5	3
86	R:R:L84	R:R:R103	3.64	No	Yes	0	5	8
87	R:R:A85	R:R:N100	3.13	No	No	0	3	3
88	R:R:C86	R:R:P87	3.77	No	No	0	9	9
89	R:R:C122	R:R:C86	7.28	No	No	0	9	9
90	R:R:C122	R:R:F90	6.98	No	Yes	0	9	5
91	R:R:D125	R:R:F90	4.78	No	Yes	0	2	5
92	R:R:L124	R:R:S94	3	No	No	0	3	4
93	R:R:K127	R:R:S95	4.59	Yes	No	0	3	3
94	R:R:I96	R:R:R99	12.53	No	No	0	5	4
95	R:R:I96	R:R:L124	2.85	No	No	0	5	3
96	R:R:G123	R:R:R99	4.5	No	No	0	3	4
97	R:R:H112	R:R:S102	8.37	No	No	0	2	5
98	R:R:R103	R:R:W110	14.99	Yes	Yes	3	8	9
99	R:R:S104	R:R:T106	4.8	No	No	0	4	4
100	R:R:P115	R:R:T111	5.25	No	No	0	5	4
101	R:R:I120	R:R:T111	7.6	No	No	0	6	4
102	R:R:H112	R:R:P115	6.1	No	No	0	2	5
103	R:R:E114	R:R:L113	3.98	No	No	0	4	3
104	R:R:G116	R:R:P117	4.06	No	No	0	8	6
105	R:R:P119	R:R:Y118	12.52	No	No	0	5	7
106	R:R:I120	R:R:Y118	7.25	No	No	0	6	7
107	R:R:A121	R:R:Y118	5.34	No	No	0	5	7
108	R:R:A121	R:R:D125	4.63	No	No	0	5	2
109	R:R:K127	R:R:L124	8.46	Yes	No	0	3	3
110	R:R:A128	R:R:L131	4.73	No	No	0	1	2
111	R:R:E133	R:R:T136	4.23	No	No	0	2	2
112	R:R:Q135	R:R:Y139	9.02	No	Yes	0	3	4
113	R:R:M370	R:R:Y139	3.59	Yes	Yes	1	6	4
114	R:R:K143	R:R:Y146	4.78	No	Yes	0	5	8
115	R:R:G145	R:R:T144	3.64	No	No	0	6	4
116	R:R:G145	R:R:I148	3.53	No	No	0	6	5
117	R:R:T147	R:R:Y146	3.75	No	Yes	0	7	8
118	R:R:Y146	R:R:Y150	2.98	Yes	Yes	1	8	8
119	R:R:D196	R:R:Y146	8.05	No	Yes	0	7	8
120	R:R:L374	R:R:Y146	5.86	Yes	Yes	1	7	8
121	R:R:G149	R:R:S378	3.71	No	No	1	8	9
122	R:R:F379	R:R:G149	4.52	No	No	1	7	8
123	R:R:R188	R:R:Y150	8.23	Yes	Yes	1	8	8
124	R:R:V192	R:R:Y150	12.62	No	Yes	0	7	8
125	R:R:S378	R:R:Y150	5.09	No	Yes	1	9	8
126	R:R:F193	R:R:G151	3.01	No	No	0	7	6
127	R:R:L152	R:R:T156	2.95	No	No	6	5	6
128	R:R:F382	R:R:L152	8.53	No	No	6	6	5
129	R:R:L157	R:R:S153	4.5	Yes	No	0	9	9
130	R:R:G381	R:R:S153	3.71	No	No	0	9	9
131	R:R:I186	R:R:L154	4.28	No	No	0	6	6
132	R:R:A189	R:R:L154	6.3	No	No	0	7	6
133	R:R:F382	R:R:T156	7.78	No	No	6	6	6
134	R:R:A385	R:R:T156	3.36	No	No	0	8	6
135	R:R:F182	R:R:L157	4.87	Yes	Yes	0	8	9
136	R:R:F185	R:R:L157	3.65	Yes	Yes	0	8	9
137	R:R:I186	R:R:L157	4.28	No	Yes	0	6	9
138	R:R:I186	R:R:L158	7.14	No	No	0	6	3
139	R:R:A160	R:R:C389	3.61	No	Yes	0	9	9
140	R:R:F182	R:R:T161	3.89	Yes	No	0	8	6
141	R:R:I183	R:R:T161	3.04	No	No	0	3	6
142	R:R:C389	R:R:I163	4.91	Yes	No	0	9	8
143	R:R:F182	R:R:L164	3.65	Yes	No	0	8	7
144	R:R:C389	R:R:L164	3.17	Yes	No	0	9	7
145	R:R:E398	R:R:F167	11.66	Yes	Yes	7	7	6
146	R:R:F167	R:R:L399	3.65	Yes	No	0	6	5
147	R:R:F167	R:R:K402	7.44	Yes	No	7	6	5
148	R:R:E398	R:R:K169	4.05	Yes	No	0	7	7
149	R:R:L170	R:R:N175	5.49	No	No	0	9	9
150	R:R:E394	R:R:L170	5.3	No	No	0	9	9
151	R:R:L170	R:R:V395	5.96	No	No	0	9	9
152	R:R:H171	R:R:Y176	7.62	No	No	0	8	6
153	R:R:C172	R:R:N175	6.3	No	No	0	8	9
154	R:R:T173	R:R:Y239	7.49	No	Yes	0	7	8
155	R:R:H178	R:R:R174	10.16	No	No	0	9	9
156	R:R:M179	R:R:Y176	3.59	No	No	0	6	6
157	R:R:F255	R:R:Y176	4.13	No	No	0	6	6
158	R:R:E236	R:R:I177	6.83	Yes	No	0	9	9
159	R:R:I177	R:R:Y239	3.63	No	Yes	0	9	8
160	R:R:F255	R:R:I177	3.77	No	No	0	6	9
161	R:R:E236	R:R:H178	9.85	Yes	No	0	9	9
162	R:R:H178	R:R:Y388	7.62	No	No	0	9	8
163	R:R:H180	R:R:W232	13.75	No	Yes	1	9	9
164	R:R:H180	R:R:I259	6.63	No	No	0	9	4
165	R:R:H180	R:R:W263	4.23	No	No	1	9	8
166	R:R:L181	R:R:S184	3	No	Yes	1	9	9
167	R:R:F185	R:R:L181	6.09	Yes	No	1	8	9
168	R:R:E236	R:R:L181	11.93	Yes	No	0	9	9
169	R:R:F182	R:R:V384	3.93	Yes	No	0	8	9
170	R:R:I183	R:R:L187	2.85	No	No	0	3	6
171	R:R:F185	R:R:S184	3.96	Yes	Yes	1	8	9
172	R:R:N229	R:R:S184	5.96	No	Yes	1	8	9
173	R:R:S184	R:R:W232	6.18	Yes	Yes	1	9	9
174	R:R:F185	R:R:N229	20.54	Yes	No	1	8	8
175	R:R:F185	R:R:L233	4.87	Yes	No	1	8	9
176	R:R:F185	R:R:Q380	9.37	Yes	Yes	1	8	9
177	R:R:F185	R:R:G381	3.01	Yes	No	0	8	9
178	R:R:R188	R:R:V226	9.15	Yes	No	0	8	5
179	R:R:N229	R:R:R188	14.46	No	Yes	1	8	8
180	R:R:F230	R:R:R188	6.41	Yes	Yes	1	8	8
181	R:R:A191	R:R:C225	3.61	No	No	0	6	6
182	R:R:F222	R:R:V192	5.24	Yes	No	0	7	7
183	R:R:D196	R:R:K195	4.15	No	Yes	0	7	7
184	R:R:K195	R:R:L199	7.05	Yes	Yes	0	7	7
185	R:R:F222	R:R:K195	18.61	Yes	Yes	0	7	7
186	R:R:F200	R:R:L199	6.09	Yes	Yes	0	4	7
187	R:R:C215	R:R:L199	3.17	No	Yes	0	9	7
188	R:R:G203	R:R:S202	3.71	No	No	0	4	3
189	R:R:Q207	R:R:S202	8.66	No	No	0	4	3
190	R:R:D206	R:R:G203	3.35	No	No	0	1	4
191	R:R:C215	R:R:C285	7.28	No	Yes	8	9	9
192	R:R:D282	R:R:K216	9.68	No	No	1	6	8
193	R:R:K216	R:R:W286	15.08	No	Yes	1	8	9
194	R:R:V220	R:R:W273	3.68	No	Yes	0	5	8
195	R:R:T274	R:R:V220	7.93	No	No	0	6	5
196	R:R:C225	R:R:F221	8.38	No	No	0	6	4
197	R:R:F222	R:R:V226	5.24	Yes	No	0	7	5
198	R:R:Q223	R:R:W294	3.29	No	Yes	1	7	7
199	R:R:I297	R:R:Q223	5.49	Yes	No	1	7	7
200	R:R:W263	R:R:Y224	3.86	No	No	0	8	9
201	R:R:T270	R:R:Y224	7.49	No	No	0	6	9
202	R:R:F231	R:R:M227	3.73	Yes	Yes	1	5	5
203	R:R:M227	R:R:P266	6.71	Yes	Yes	1	5	9
204	R:R:F269	R:R:M227	4.98	No	Yes	0	6	5
205	R:R:I297	R:R:M227	4.37	Yes	Yes	1	7	5
206	R:R:I301	R:R:M227	7.29	No	Yes	0	7	5
207	R:R:A228	R:R:P266	3.74	No	Yes	0	8	9
208	R:R:F230	R:R:I301	7.54	Yes	No	0	8	7
209	R:R:F230	R:R:I305	5.02	Yes	No	1	8	7
210	R:R:F230	R:R:Y354	12.38	Yes	Yes	1	8	8
211	R:R:F231	R:R:V265	6.55	Yes	No	1	5	5
212	R:R:F231	R:R:P266	13	Yes	Yes	1	5	9
213	R:R:F231	R:R:P300	2.89	Yes	No	0	5	9
214	R:R:F231	R:R:S304	5.28	Yes	No	0	5	7
215	R:R:V235	R:R:W232	7.36	No	Yes	0	7	9
216	R:R:G262	R:R:W232	5.63	No	Yes	0	9	9
217	R:R:W232	R:R:W263	16.87	Yes	No	1	9	8
218	R:R:L233	R:R:Q380	7.99	No	Yes	1	9	9
219	R:R:L234	R:R:V307	2.98	No	No	0	8	6
220	R:R:L234	R:R:N308	4.12	No	No	0	8	9
221	R:R:E236	R:R:L349	7.95	Yes	No	0	9	9
222	R:R:F350	R:R:G237	6.02	Yes	No	0	9	9
223	R:R:L238	R:R:T242	2.95	No	No	4	6	7
224	R:R:L238	R:R:Y258	8.21	No	No	4	6	7
225	R:R:L243	R:R:Y239	17.58	No	Yes	4	7	8
226	R:R:E251	R:R:Y239	8.98	No	Yes	4	6	8
227	R:R:Y239	R:R:Y258	3.97	Yes	No	4	8	7
228	R:R:L240	R:R:L244	8.3	No	No	2	9	8
229	R:R:I315	R:R:L240	5.71	No	No	2	9	9
230	R:R:F350	R:R:L240	3.65	Yes	No	2	9	9
231	R:R:A245	R:R:Y241	4	No	Yes	0	7	8
232	R:R:L311	R:R:Y241	9.38	No	Yes	0	8	8
233	R:R:C314	R:R:Y241	4.03	No	Yes	0	8	8
234	R:R:I315	R:R:Y241	3.63	No	Yes	0	9	8
235	R:R:T242	R:R:Y258	6.24	No	No	4	7	7
236	R:R:E251	R:R:L243	6.63	No	No	4	6	7
237	R:R:I315	R:R:L244	5.71	No	No	2	9	8
238	R:R:I318	R:R:L244	7.14	No	No	0	8	8
239	R:R:F249	R:R:V246	5.24	No	No	0	5	4
240	R:R:E251	R:R:F249	13.99	No	No	0	6	5
241	R:R:F249	R:R:Y254	13.41	No	No	0	5	4
242	R:R:K253	R:R:S250	6.12	No	No	0	4	7
243	R:R:K253	R:R:Y254	8.36	No	No	0	4	4
244	R:R:F255	R:R:I259	10.05	No	No	0	6	4
245	R:R:G257	R:R:W256	5.63	No	No	0	2	3
246	R:R:G264	R:R:S267	3.71	No	No	0	7	3
247	R:R:P266	R:R:V265	3.53	Yes	No	1	9	5
248	R:R:S267	R:R:T268	3.2	No	No	0	3	4
249	R:R:F269	R:R:P300	13	No	No	0	6	9
250	R:R:I296	R:R:V272	3.07	No	No	0	8	4
251	R:R:R277	R:R:W273	11	Yes	Yes	1	8	8
252	R:R:W273	R:R:W286	6.56	Yes	Yes	1	8	9
253	R:R:I297	R:R:W273	10.57	Yes	Yes	1	7	8
254	R:R:I278	R:R:T274	3.04	No	No	0	3	6
255	R:R:A276	R:R:L293	4.73	No	No	0	4	4
256	R:R:R277	R:R:W286	26.99	Yes	Yes	1	8	9
257	R:R:R277	R:R:T288	3.88	Yes	Yes	0	8	4
258	R:R:I278	R:R:W286	3.52	No	Yes	0	3	9
259	R:R:F280	R:R:H279	7.92	No	No	0	3	1
260	R:R:D282	R:R:W286	6.7	No	Yes	1	6	9
261	R:R:C285	R:R:D287	4.67	Yes	No	0	9	5
262	R:R:D287	R:R:T288	2.89	No	Yes	0	5	4
263	R:R:N290	R:R:T288	8.77	No	Yes	0	3	4
264	R:R:I289	R:R:W294	15.27	No	Yes	0	8	7
265	R:R:N290	R:R:S291	4.47	No	No	0	3	5
266	R:R:I296	R:R:L293	2.85	No	No	0	8	4
267	R:R:I297	R:R:W294	7.05	Yes	Yes	1	7	7
268	R:R:K298	R:R:W294	15.08	No	Yes	0	7	7
269	R:R:K298	R:R:W295	15.08	No	No	0	7	6
270	R:R:K298	R:R:L302	4.23	No	No	0	7	4
271	R:R:G299	R:R:P300	4.06	No	No	0	4	9
272	R:R:I301	R:R:S304	3.1	No	No	0	7	7
273	R:R:I305	R:R:Y354	4.84	No	Yes	1	7	8
274	R:R:I305	R:R:I355	2.94	No	No	0	7	5
275	R:R:L311	R:R:V307	2.98	No	No	0	8	6
276	R:R:F350	R:R:N308	4.83	Yes	No	0	9	9
277	R:R:F309	R:R:I313	7.54	No	No	0	5	5
278	R:R:F309	R:R:V352	3.93	No	No	0	5	6
279	R:R:F309	R:R:I355	10.05	No	No	0	5	5
280	R:R:F312	R:R:I316	8.79	Yes	No	2	9	7
281	R:R:F312	R:R:T343	6.49	Yes	No	2	9	9
282	R:R:F312	R:R:F350	7.5	Yes	Yes	2	9	9
283	R:R:F312	R:R:V352	6.55	Yes	No	0	9	6
284	R:R:I316	R:R:L339	5.71	No	Yes	2	7	8
285	R:R:I316	R:R:T343	4.56	No	No	2	7	9
286	R:R:L319	R:R:L323	4.15	No	No	0	8	8
287	R:R:L319	R:R:L339	4.15	No	Yes	0	8	8
288	R:R:L319	R:R:S342	3	No	No	0	8	9
289	R:R:L320	R:R:R324	4.86	No	No	0	5	6
290	R:R:K322	R:R:Q321	5.42	No	No	0	9	7
291	R:R:L323	R:R:R338	3.64	No	No	0	8	8
292	R:R:P325	R:R:R324	4.32	Yes	No	0	6	6
293	R:R:K330	R:R:P325	3.35	No	Yes	9	4	6
294	R:R:D332	R:R:P325	4.83	No	Yes	9	7	6
295	R:R:D327	R:R:I328	5.6	No	No	0	6	6
296	R:R:I328	R:R:K330	5.82	No	No	0	6	4
297	R:R:D332	R:R:K330	5.53	No	No	9	7	4
298	R:R:S334	R:R:S337	6.52	No	No	0	5	6
299	R:R:R338	R:R:R341	9.6	No	No	0	8	8
300	R:R:L339	R:R:T343	2.95	Yes	No	2	8	9
301	R:R:I347	R:R:P348	3.39	No	No	0	8	9
302	R:R:P348	R:R:V383	5.3	No	No	0	9	5
303	R:R:P348	R:R:V384	3.53	No	No	0	9	9
304	R:R:F350	R:R:L349	4.87	Yes	No	0	9	9
305	R:R:L349	R:R:Y388	21.1	No	No	0	9	8
306	R:R:G351	R:R:H353	3.18	No	Yes	1	9	8
307	R:R:G351	R:R:Q380	3.29	No	Yes	1	9	9
308	R:R:H353	R:R:Y354	16.33	Yes	Yes	1	8	8
309	R:R:F372	R:R:H353	5.66	No	Yes	1	4	8
310	R:R:H353	R:R:V376	5.54	Yes	No	1	8	5
311	R:R:H353	R:R:Q380	7.42	Yes	Yes	1	8	9
312	R:R:E373	R:R:Y354	8.98	No	Yes	0	7	8
313	R:R:G377	R:R:Y354	2.9	No	Yes	1	6	8
314	R:R:Q380	R:R:Y354	6.76	Yes	Yes	1	9	8
315	R:R:F359	R:R:I355	7.54	No	No	0	5	5
316	R:R:F357	R:R:F360	8.57	Yes	No	0	6	5
317	R:R:F357	R:R:V368	7.87	Yes	No	0	6	4
318	R:R:F357	R:R:F372	10.72	Yes	No	0	6	4
319	R:R:F360	R:R:N363	7.25	No	No	0	5	4
320	R:R:D362	R:R:K365	4.15	No	No	0	4	2
321	R:R:F364	R:R:N363	6.04	No	No	0	3	4
322	R:R:E367	R:R:F364	9.33	No	No	0	3	3
323	R:R:F364	R:R:V368	5.24	No	No	0	3	4
324	R:R:K365	R:R:K369	8.62	No	No	0	2	8
325	R:R:E367	R:R:P366	11	No	No	0	3	5
326	R:R:E373	R:R:K369	8.1	No	No	0	7	8
327	R:R:F372	R:R:V376	10.49	No	No	1	4	5
328	R:R:G377	R:R:Q380	3.29	No	Yes	1	6	9
329	R:R:F379	R:R:S378	3.96	No	No	1	7	9
330	R:R:F382	R:R:I386	11.3	No	No	0	6	5
331	R:R:L387	R:R:V383	2.98	No	No	0	8	5
332	R:R:F390	R:R:I386	3.77	No	No	0	9	5
333	R:R:C389	R:R:F390	4.19	Yes	No	0	9	9
334	R:R:N392	R:R:V395	8.87	No	No	0	9	9
335	R:R:L399	R:R:V395	2.98	No	No	0	5	9
336	R:R:Q396	R:R:R400	7.01	No	No	0	7	5
337	R:R:E398	R:R:R401	10.47	Yes	No	0	7	7
338	R:R:E398	R:R:K402	5.4	Yes	No	7	7	5
339	R:R:R404	R:R:W403	4	No	No	0	3	6
340	R:R:H407	R:R:W403	14.81	No	No	0	5	6
341	R:R:H407	R:R:W406	9.52	No	No	0	5	5
342	R:R:K91	R:R:L88	2.82	No	No	0	3	3
343	L:L:K20	R:R:D126	2.77	No	No	0	0	1
344	R:R:A191	R:R:F222	2.77	No	Yes	0	6	7
345	R:R:L320	R:R:L339	2.77	No	Yes	0	5	8
346	R:R:L345	R:R:L346	2.77	No	No	0	8	9
347	R:R:L56	R:R:N58	2.75	No	No	0	2	1
348	R:R:I96	R:R:Q97	2.74	No	No	0	5	4
349	R:R:D201	R:R:L197	2.71	No	No	0	4	2
350	R:R:P74	R:R:W73	2.7	No	Yes	0	5	9
351	R:R:H279	R:R:I278	2.65	No	No	0	1	3
352	R:R:F248	R:R:S247	2.64	No	No	0	6	7
353	L:L:F6	R:R:V142	2.62	Yes	No	0	0	5
354	R:R:R103	R:R:V101	2.62	Yes	No	0	8	6
355	R:R:F138	R:R:V371	2.62	No	No	0	5	5
356	R:R:F379	R:R:V375	2.62	No	No	0	7	5
357	R:R:R78	R:R:T60	2.59	No	No	0	5	2
358	R:R:H47	R:R:L51	2.57	No	No	0	4	3
359	R:R:E44	R:R:Q41	2.55	No	No	0	5	4
360	R:R:S267	R:R:Y224	2.54	No	No	0	3	9
361	R:R:F90	R:R:I89	2.51	Yes	No	0	5	5
362	R:R:F357	R:R:M356	2.49	Yes	No	0	6	6
363	R:R:F93	R:R:K127	2.48	No	Yes	0	4	3
364	R:R:F193	R:R:L154	2.44	No	No	0	7	6
365	R:R:F359	R:R:L306	2.44	No	No	0	5	3
366	R:R:F312	R:R:L346	2.44	Yes	No	2	9	9
367	R:R:F350	R:R:L346	2.44	Yes	No	2	9	9
368	R:R:L293	R:R:R277	2.43	No	Yes	0	4	8
369	L:L:I26	L:L:Y22	2.42	No	No	0	0	0
370	L:L:Y22	R:R:I43	2.42	No	No	0	0	6
371	R:R:I89	R:R:Y39	2.42	No	No	0	5	4
372	R:R:N175	R:R:R174	2.41	No	No	0	9	9
373	R:R:N392	R:R:R174	2.41	No	No	0	9	9
374	L:L:L13	L:L:Y10	2.34	No	Yes	0	0	0
375	R:R:E281	R:R:F280	2.33	No	No	0	6	3
376	R:R:E281	R:R:Y283	2.24	No	No	0	6	3
377	R:R:R324	R:R:Y336	2.06	No	No	0	6	6
378	R:R:G116	R:R:P115	2.03	No	No	0	8	5
379	R:R:R405	R:R:W406	2	No	No	0	7	5
380	R:R:C285	R:R:G211	1.96	Yes	No	0	9	5
381	R:R:A217	R:R:G214	1.95	No	No	0	4	3
382	R:R:P325	R:R:P326	1.95	Yes	No	0	6	6
383	R:R:G109	R:R:T106	1.82	No	No	0	9	4
384	R:R:A198	R:R:A218	1.79	No	No	0	4	5
385	R:R:G149	R:R:I148	1.76	No	No	0	8	5
386	R:R:G262	R:R:I261	1.76	No	No	0	9	6
387	R:R:G140	R:R:K143	1.74	No	No	0	3	5
388	R:R:G284	R:R:K216	1.74	No	No	0	4	8
389	R:R:A54	R:R:S64	1.71	No	No	0	2	4
390	R:R:G257	R:R:L260	1.71	No	No	0	2	3
391	R:R:G393	R:R:N392	1.7	No	No	0	6	9
392	R:R:E108	R:R:G109	1.64	No	No	0	5	9
393	R:R:E210	R:R:G211	1.64	No	No	0	4	5
394	R:R:C314	R:R:I310	1.64	No	No	0	8	3
395	R:R:A218	R:R:I194	1.62	No	No	0	5	5
396	R:R:A128	R:R:K127	1.61	No	Yes	0	1	3
397	R:R:T303	R:R:V307	1.59	No	No	0	3	6
398	R:R:A198	R:R:L199	1.58	No	Yes	0	4	7
399	R:R:A358	R:R:L302	1.58	No	No	0	6	4
400	R:R:C63	R:R:D107	1.56	No	No	0	9	1
401	L:L:K21	R:R:S205	1.53	No	No	0	0	1
402	R:R:C215	R:R:Q207	1.53	No	No	8	9	4
403	R:R:C285	R:R:Q207	1.53	Yes	No	8	9	4
404	R:R:C50	R:R:E52	1.52	No	No	0	8	4
405	R:R:I61	R:R:T60	1.52	No	No	0	1	2
406	L:L:T7	R:R:M219	1.51	No	No	0	0	5
407	R:R:A75	R:R:E59	1.51	No	No	0	4	3
408	L:L:L23	L:L:V19	1.49	No	No	0	0	0
409	R:R:N100	R:R:V83	1.48	No	No	0	3	3
410	R:R:D206	R:R:S205	1.47	No	No	0	1	1
411	R:R:I318	R:R:K322	1.45	No	No	0	8	9
412	R:R:Q134	R:R:S130	1.44	No	No	0	1	1
413	R:R:F360	R:R:P361	1.44	No	No	0	5	8
414	R:R:Q49	R:R:V45	1.43	No	No	0	4	3
415	R:R:P335	R:R:Y336	1.39	No	No	0	7	6
416	R:R:D201	R:R:K143	1.38	No	No	0	4	5
417	R:R:L387	R:R:L391	1.38	No	No	0	8	6
418	L:L:L27	L:L:N28	1.37	No	No	0	0	0
419	R:R:M42	R:R:Q41	1.36	No	No	0	4	4
420	L:L:K15	R:R:E36	1.35	No	No	0	0	6
421	L:L:M17	R:R:E204	1.35	No	No	0	0	4
422	R:R:E52	R:R:K65	1.35	No	No	0	4	3
423	R:R:E57	R:R:L56	1.33	No	No	0	3	2
424	R:R:L131	R:R:Q134	1.33	No	No	0	2	1
425	R:R:F390	R:R:V159	1.31	No	No	0	9	5
426	R:R:S292	R:R:W295	1.24	No	No	0	3	6
427	R:R:F167	R:R:L166	1.22	Yes	No	0	6	1
428	R:R:H171	R:R:R168	1.13	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	8.506	5	1	0
2	L:L:D3	5.876	5	1	0
3	L:L:F6	5.34	5	1	0
4	L:L:Y10	8.5225	4	1	0
5	L:L:Q16	4.81	4	5	0
6	R:R:W67	9.63	4	0	6
7	R:R:T71	7.88	4	3	5
8	R:R:W73	6.77	5	3	9
9	R:R:T76	5.56	4	3	7
10	R:R:F90	5.09	4	0	5
11	R:R:R103	7.438	5	3	8
12	R:R:W110	14.6275	4	3	9
13	R:R:K127	4.285	4	0	3
14	R:R:Y139	5.502	5	1	4
15	R:R:Y146	6.12833	6	1	8
16	R:R:Y150	6.934	5	1	8
17	R:R:L157	4.325	4	0	9
18	R:R:F167	5.9925	4	7	6
19	R:R:F182	4.085	4	0	8
20	R:R:S184	4.775	4	1	9
21	R:R:F185	7.35571	7	1	8
22	R:R:R188	8.842	5	1	8
23	R:R:K195	10.455	4	0	7
24	R:R:L199	4.4725	4	0	7
25	R:R:F200	8.395	4	1	4
26	R:R:F222	7.328	5	0	7
27	R:R:M227	5.416	5	1	5
28	R:R:F230	7.8375	4	1	8
29	R:R:F231	6.29	5	1	5
30	R:R:W232	9.958	5	1	9
31	R:R:E236	9.14	4	0	9
32	R:R:Y239	8.33	5	4	8
33	R:R:Y241	5.26	4	0	8
34	R:R:P266	6.745	4	1	9
35	R:R:W273	7.9525	4	1	8
36	R:R:R277	11.075	4	1	8
37	R:R:C285	3.86	4	8	9
38	R:R:W286	11.77	5	1	9
39	R:R:T288	5.1775	4	0	4
40	R:R:W294	8.31167	6	1	7
41	R:R:I297	6.87	4	1	7
42	R:R:F312	6.354	5	2	9
43	R:R:P325	3.6125	4	9	6
44	R:R:L339	3.895	4	2	8
45	R:R:F350	4.885	6	2	9
46	R:R:H353	7.626	5	1	8
47	R:R:Y354	8.69833	6	1	8
48	R:R:F357	7.4125	4	0	6
49	R:R:M370	3.3575	4	1	6
50	R:R:L374	5.9525	4	1	7
51	R:R:Q380	6.35333	6	1	9
52	R:R:C389	3.97	4	0	9
53	R:R:E398	7.895	4	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	R:R:R188	49.64	5.96	Yes	Yes	1	0	8
2	R:R:R188	R:R:V226	38.0313	9.15	Yes	No	0	8	5
3	L:L:D3	R:R:F222	34.0897	4.78	Yes	Yes	0	0	7
4	R:R:F222	R:R:V226	33.8633	5.24	Yes	No	0	7	5
5	L:L:D3	R:R:L374	12.1826	4.07	Yes	Yes	1	0	7
6	L:L:S2	R:R:M370	12.1011	3.07	No	Yes	0	0	6
7	L:L:F6	R:R:L374	11.8275	4.87	Yes	Yes	1	0	7
8	L:L:S2	R:R:E373	12.3243	4.31	No	No	0	0	7
9	L:L:F6	R:R:Y139	23.6999	4.13	Yes	Yes	1	0	4
10	R:R:Y146	R:R:Y150	13.3719	2.98	Yes	Yes	1	8	8
11	R:R:F222	R:R:K195	67.4831	18.61	Yes	Yes	0	7	7
12	L:L:T7	R:R:K195	22.8306	12.01	No	Yes	0	0	7
13	L:L:T7	R:R:F200	22.2485	7.78	No	Yes	0	0	4
14	R:R:K195	R:R:L199	44.978	7.05	Yes	Yes	0	7	7
15	R:R:F200	R:R:L199	22.6173	6.09	Yes	Yes	0	4	7
16	L:L:R14	R:R:F200	43.9719	3.21	No	Yes	1	0	4
17	L:L:Y10	R:R:Y139	35.2949	4.96	Yes	Yes	1	0	4
18	L:L:R14	L:L:Y10	34.1094	10.29	No	Yes	1	0	0
19	R:R:C215	R:R:L199	22.1085	3.17	No	Yes	0	9	7
20	R:R:C215	R:R:C285	19.9935	7.28	No	Yes	8	9	9
21	R:R:C285	R:R:D287	19.9525	4.67	Yes	No	0	9	5
22	L:L:T11	R:R:D287	26.5424	10.12	No	No	0	0	5
23	L:L:K15	L:L:T11	26.3039	3	No	No	0	0	0
24	R:R:I297	R:R:W273	15.2467	10.57	Yes	Yes	1	7	8
25	L:L:R14	R:R:E204	77.4254	12.79	No	No	0	0	4
26	L:L:M17	R:R:E204	76.1354	1.35	No	No	0	0	4
27	L:L:M17	L:L:Q16	74.8126	5.44	No	Yes	5	0	0
28	L:L:Q16	R:R:E36	64.756	6.37	Yes	No	0	0	6
29	L:L:K15	R:R:E36	25.631	1.35	No	No	0	0	6
30	L:L:Q16	R:R:F93	12.4112	3.51	Yes	No	0	0	4
31	R:R:E36	R:R:L92	87.9881	15.9	No	No	0	6	4
32	R:R:L92	R:R:Y39	87.092	4.69	No	No	0	4	4
33	R:R:I89	R:R:Y39	85.2966	2.42	No	No	0	5	4
34	R:R:I43	R:R:I89	25.6972	2.94	No	No	0	6	5
35	L:L:Y22	R:R:I43	11.0064	2.42	No	No	0	0	6
36	R:R:F90	R:R:I89	58.9286	2.51	Yes	No	0	5	5
37	R:R:I43	R:R:W67	14.8304	4.7	No	Yes	0	6	6
38	R:R:C72	R:R:W67	10.9035	7.84	No	Yes	0	9	6
39	R:R:C122	R:R:F90	41.8772	6.98	No	Yes	0	9	5
40	R:R:C122	R:R:C86	40.9379	7.28	No	No	0	9	9
41	R:R:C86	R:R:P87	40.0068	3.77	No	No	0	9	9
42	R:R:P87	R:R:T71	39.0795	3.5	No	Yes	0	9	5
43	R:R:R103	R:R:T71	20.4925	12.94	Yes	Yes	3	8	5
44	R:R:R103	R:R:W73	16.628	3	Yes	Yes	3	8	9
45	R:R:T71	R:R:W110	18.5394	12.13	Yes	Yes	3	5	9
46	R:R:W110	R:R:W73	16.6089	16.87	Yes	Yes	3	9	9
47	R:R:C105	R:R:W73	19.5625	5.22	No	Yes	3	9	9
48	R:R:C105	R:R:C63	17.6357	7.28	No	No	0	9	9
49	R:R:C63	R:R:I61	13.7242	3.27	No	No	0	9	1
50	R:R:D125	R:R:F90	14.3298	4.78	No	Yes	0	2	5
51	R:R:A121	R:R:D125	13.3752	4.63	No	No	0	5	2
52	R:R:A121	R:R:Y118	12.4446	5.34	No	No	0	5	7
53	R:R:I120	R:R:Y118	10.5933	7.25	No	No	0	6	7
54	R:R:N229	R:R:R188	100	14.46	No	Yes	1	8	8
55	R:R:F185	R:R:N229	54.1128	20.54	Yes	No	1	8	8
56	R:R:F185	R:R:L157	22.7721	3.65	Yes	Yes	0	8	9
57	R:R:F182	R:R:L157	16.5914	4.87	Yes	Yes	0	8	9
58	R:R:N229	R:R:S184	45.3981	5.96	No	Yes	1	8	9
59	R:R:L181	R:R:S184	34.6899	3	No	Yes	1	9	9
60	R:R:E236	R:R:L181	74.7831	11.93	Yes	No	0	9	9
61	R:R:E236	R:R:H178	23.9816	9.85	Yes	No	0	9	9
62	R:R:H178	R:R:R174	21.7162	10.16	No	No	0	9	9
63	R:R:N392	R:R:R174	14.4835	2.41	No	No	0	9	9
64	R:R:N392	R:R:V395	11.5994	8.87	No	No	0	9	9
65	R:R:L399	R:R:V395	10.1666	2.98	No	No	0	5	9
66	R:R:F185	R:R:L181	41.4084	6.09	Yes	No	1	8	9
67	R:R:E236	R:R:I177	25.4199	6.83	Yes	No	0	9	9
68	R:R:S184	R:R:W232	11.5387	6.18	Yes	Yes	1	9	9
69	R:R:I177	R:R:Y239	17.0153	3.63	No	Yes	0	9	8
70	R:R:E236	R:R:L349	26.8904	7.95	Yes	No	0	9	9
71	R:R:F230	R:R:I301	10.2301	7.54	Yes	No	0	8	7
72	R:R:F350	R:R:L349	24.736	4.87	Yes	No	0	9	9
73	R:R:F350	R:R:L240	15.4742	3.65	Yes	No	2	9	9
74	R:R:I305	R:R:I355	12.3992	2.94	No	No	0	7	5
75	R:R:F309	R:R:I355	11.7608	10.05	No	No	0	5	5
76	R:R:F309	R:R:V352	11.3724	3.93	No	No	0	5	6
77	R:R:F312	R:R:V352	11.2148	6.55	Yes	No	0	9	6
78	R:R:M370	R:R:Y139	12.3396	3.59	Yes	Yes	1	6	4
79	L:L:F6	R:R:Y146	12.5272	11.35	Yes	Yes	1	0	8
80	R:R:R188	R:R:Y150	13.6947	8.23	Yes	Yes	1	8	8
81	R:R:E373	R:R:Y354	12.7231	8.98	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q223	8.65	1	Yes	No	0	7	0	1
L:L:H1	R:R:V226	12.45	1	Yes	No	0	5	0	1
L:L:H1	R:R:W294	5.29	1	Yes	Yes	0	7	0	1
L:L:S2	R:R:M370	3.07	0	No	Yes	0	6	0	1
L:L:S2	R:R:E373	4.31	0	No	No	0	7	0	1
L:L:S2	R:R:L374	9.01	0	No	Yes	0	7	0	1
L:L:D3	R:R:Y150	5.75	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:R188	5.96	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:F222	4.78	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:L374	4.07	1	Yes	Yes	0	7	0	1
L:L:A4	R:R:W294	3.89	1	No	Yes	0	7	0	1
L:L:V5	R:R:I289	3.07	0	No	No	0	8	0	1
L:L:V5	R:R:K365	3.04	0	No	No	0	2	0	1
L:L:V5	R:R:M370	3.04	0	No	Yes	0	6	0	1
L:L:F6	R:R:Y139	4.13	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:Y146	11.35	1	Yes	Yes	0	8	0	1
L:L:F6	R:R:M370	3.73	1	Yes	Yes	0	6	0	1
L:L:F6	R:R:L374	4.87	1	Yes	Yes	0	7	0	1
L:L:T7	R:R:K195	12.01	0	No	Yes	0	7	0	1
L:L:T7	R:R:F200	7.78	0	No	Yes	0	4	0	1
L:L:D8	R:R:I289	7	0	No	No	0	8	0	1
L:L:N9	R:R:Y139	5.81	0	No	Yes	0	4	0	1
L:L:Y10	R:R:Y139	4.96	1	Yes	Yes	0	4	0	1
L:L:Y10	R:R:F200	16.5	1	Yes	Yes	0	4	0	1
L:L:T11	R:R:D287	10.12	0	No	No	0	5	0	1
L:L:R12	R:R:T288	5.17	0	No	Yes	0	4	0	1
L:L:L13	R:R:T136	2.95	0	No	No	0	2	0	1
L:L:R14	R:R:F200	3.21	1	No	Yes	0	4	0	1
L:L:R14	R:R:E204	12.79	1	No	No	0	4	0	1
L:L:K15	R:R:C37	8.08	0	No	No	0	6	0	1
L:L:Q16	R:R:E36	6.37	5	Yes	No	0	6	0	1
L:L:Q16	R:R:F93	3.51	5	Yes	No	0	4	0	1
L:L:Q16	R:R:D132	3.92	5	Yes	No	0	1	0	1
L:L:M17	R:R:D132	6.93	5	No	No	0	1	0	1
L:L:A18	R:R:E204	3.02	0	No	No	0	4	0	1
L:L:K20	R:R:F93	3.72	0	No	No	0	4	0	1
L:L:Y22	R:R:V40	5.05	0	No	No	0	3	0	1
L:L:L23	R:R:F90	6.09	0	No	Yes	0	5	0	1
L:L:N24	R:R:D126	5.39	0	No	No	0	1	0	1
L:L:I26	R:R:N69	5.66	0	No	No	0	4	0	1
L:L:N28	R:R:N69	8.17	0	No	No	0	4	0	1
R:R:E36	R:R:L92	15.9	0	No	No	6	4	1	2
R:R:C208	R:R:C37	7.28	0	No	No	4	6	2	1
R:R:Q41	R:R:V40	4.3	0	No	No	4	3	2	1
R:R:I43	R:R:W67	4.7	0	No	Yes	6	6	1	2
R:R:I43	R:R:I89	2.94	0	No	No	6	5	1	2
R:R:L70	R:R:N69	4.12	0	No	No	6	4	2	1
R:R:C122	R:R:F90	6.98	0	No	Yes	9	5	2	1
R:R:D125	R:R:F90	4.78	0	No	Yes	2	5	2	1
R:R:E133	R:R:T136	4.23	0	No	No	2	2	2	1
R:R:Q135	R:R:Y139	9.02	0	No	Yes	3	4	2	1
R:R:M370	R:R:Y139	3.59	1	Yes	Yes	6	4	1	1
R:R:K143	R:R:Y146	4.78	0	No	Yes	5	8	2	1
R:R:T147	R:R:Y146	3.75	0	No	Yes	7	8	2	1
R:R:Y146	R:R:Y150	2.98	1	Yes	Yes	8	8	1	1
R:R:D196	R:R:Y146	8.05	0	No	Yes	7	8	2	1
R:R:L374	R:R:Y146	5.86	1	Yes	Yes	7	8	1	1
R:R:R188	R:R:Y150	8.23	1	Yes	Yes	8	8	1	1
R:R:V192	R:R:Y150	12.62	0	No	Yes	7	8	2	1
R:R:S378	R:R:Y150	5.09	1	No	Yes	9	8	2	1
R:R:R188	R:R:V226	9.15	1	Yes	No	8	5	1	1
R:R:N229	R:R:R188	14.46	1	No	Yes	8	8	2	1
R:R:F230	R:R:R188	6.41	1	Yes	Yes	8	8	2	1
R:R:F222	R:R:V192	5.24	0	Yes	No	7	7	1	2
R:R:D196	R:R:K195	4.15	0	No	Yes	7	7	2	1
R:R:K195	R:R:L199	7.05	0	Yes	Yes	7	7	1	2
R:R:F222	R:R:K195	18.61	0	Yes	Yes	7	7	1	1
R:R:F200	R:R:L199	6.09	1	Yes	Yes	4	7	1	2
R:R:F222	R:R:V226	5.24	0	Yes	No	7	5	1	1
R:R:Q223	R:R:W294	3.29	1	No	Yes	7	7	1	1
R:R:I297	R:R:Q223	5.49	1	Yes	No	7	7	2	1
R:R:F230	R:R:Y354	12.38	1	Yes	Yes	8	8	2	2
R:R:R277	R:R:T288	3.88	1	Yes	Yes	8	4	2	1
R:R:C285	R:R:D287	4.67	8	Yes	No	9	5	2	1
R:R:D287	R:R:T288	2.89	0	No	Yes	5	4	1	1
R:R:N290	R:R:T288	8.77	0	No	Yes	3	4	2	1
R:R:I289	R:R:W294	15.27	0	No	Yes	8	7	1	1
R:R:I297	R:R:W294	7.05	1	Yes	Yes	7	7	2	1
R:R:K298	R:R:W294	15.08	0	No	Yes	7	7	2	1
R:R:E373	R:R:Y354	8.98	0	No	Yes	7	8	1	2
R:R:D362	R:R:K365	4.15	0	No	No	4	2	2	1
R:R:K365	R:R:K369	8.62	0	No	No	2	8	1	2
R:R:E373	R:R:K369	8.1	0	No	No	7	8	1	2
L:L:K20	R:R:D126	2.77	0	No	No	0	1	0	1
R:R:A191	R:R:F222	2.77	0	No	Yes	6	7	2	1
L:L:F6	R:R:V142	2.62	1	Yes	No	0	5	0	1
R:R:F90	R:R:I89	2.51	0	Yes	No	5	5	1	2
R:R:F93	R:R:K127	2.48	0	No	Yes	4	3	1	2
L:L:Y22	R:R:I43	2.42	0	No	No	0	6	0	1
L:L:K21	R:R:S205	1.53	0	No	No	0	1	0	1
L:L:T7	R:R:M219	1.51	0	No	No	0	5	0	1
R:R:D206	R:R:S205	1.47	0	No	No	1	1	2	1
L:L:K15	R:R:E36	1.35	0	No	No	0	6	0	1
L:L:M17	R:R:E204	1.35	5	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E3Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	377
Number of Links	428
Number of Hubs	53
Number of Links mediated by Hubs	194
Number of Communities	9
Number of Nodes involved in Communities	81
Number of Links involved in Communities	109

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	272991
Length Of Smallest Path	3
Average Path Length	22.0112
Length of Longest Path	40
Minimum Path Strength	1.385
Average Path Strength	7.03719
Maximum Path Strength	21.035
Minimum Path Correlation	0.7
Average Path Correlation	0.959172
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	56.3864
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.3293
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • vasoactive intestinal polypeptide receptor binding • signaling receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • type 1 vasoactive intestinal polypeptide receptor binding • body fluid secretion • localization • regulation of body fluid levels • secretion • transport • regulation of biological quality • establishment of localization • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • establishment of protein localization • nitrogen compound transport • hormone secretion • protein localization to extracellular region • peptide secretion • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of hormone levels • prolactin secretion • establishment of protein localization to extracellular region • export from cell • protein secretion • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • regulation of localization • regulation of protein localization • monoamine transport • epinephrine secretion • organic hydroxy compound transport • organic cation transport • catecholamine secretion • catecholamine transport • epinephrine transport • catabolic process • positive regulation of protein metabolic process • macromolecule catabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • protein catabolic process • regulation of catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • regulation of protein catabolic process • negative regulation of biological process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • mRNA stabilization • mRNA catabolic process • negative regulation of metabolic process • nucleobase-containing compound catabolic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of macromolecule biosynthetic process • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • negative regulation of RNA metabolic process • RNA metabolic process • negative regulation of mRNA metabolic process • regulation of mRNA catabolic process • positive regulation of biosynthetic process • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of catabolic process • negative regulation of mRNA catabolic process • negative regulation of RNA catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of mRNA stability • RNA stabilization • negative regulation of biosynthetic process • positive regulation of gene expression • regulation of RNA stability • regulation of mRNA metabolic process • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • vasoactive intestinal polypeptide receptor activity • cell surface receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32241
Sequence	>8E3Z_nogp_Chain_R E C D Y V Q M I E V Q H K Q C L E E A Q L E N E T I G C S K M W D N L T C W P A T P R G Q V V V L A C P L I F K L F S S I Q G R N V S R S C T D E G W T H L E P G P Y P I A C G L D D K A A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F R K L H C T R N Y I H M H L F I S F I L R A A A V F I K D L A L F D S G E S D Q C S E G S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S F F S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E D Y G C W D T I N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L R P P D I R K S D S S P Y S R L A R S T L L L I P L F G V H Y I M F A F F P D N F K P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E V Q A E L R R K W R R W H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6VN7	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.2	2020-09-02	doi.org/10.1038/s41467-020-17933-8
	6VN7 (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP	-		3.2	2020-09-02	doi.org/10.1038/s41467-020-17933-8
	8E3Y	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Y (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Z	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	2.7	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3Z (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	VIP	-		2.7	2022-11-23	doi.org/10.1038/s41467-022-34629-3

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