psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S416	R:R:T264	6.4	No	No	0	2	5
2	R:R:Q273	R:R:T269	5.67	No	No	0	4	6
3	R:R:T269	R:R:V327	4.76	No	No	0	6	5
4	R:R:I271	R:R:V503	6.14	No	No	0	8	6
5	R:R:I271	R:R:Y504	9.67	No	No	0	8	8
6	R:R:F323	R:R:S272	5.28	Yes	No	0	9	8
7	R:R:C276	R:R:N320	6.3	No	Yes	0	7	7
8	R:R:C276	R:R:F323	5.59	No	Yes	0	7	9
9	R:R:C276	R:R:L324	6.35	No	No	0	7	7
10	R:R:S511	R:R:V278	4.85	No	No	0	8	5
11	R:R:N320	R:R:S279	7.45	Yes	No	2	7	9
12	R:R:N510	R:R:S279	5.96	No	No	2	9	9
13	R:R:G514	R:R:S279	3.71	No	No	0	9	9
14	R:R:F317	R:R:M280	9.95	No	Yes	0	6	6
15	R:R:M280	R:R:N320	4.21	Yes	Yes	0	6	7
16	R:R:L321	R:R:M280	4.24	No	Yes	0	5	6
17	R:R:L324	R:R:M280	4.24	No	Yes	0	7	6
18	R:R:F282	R:R:V515	6.55	No	No	0	7	6
19	R:R:C518	R:R:F282	6.98	No	No	0	8	7
20	R:R:F317	R:R:L283	4.87	No	Yes	0	6	7
21	R:R:G514	R:R:L283	3.42	No	Yes	0	9	7
22	R:R:C518	R:R:T286	3.38	No	No	0	8	8
23	R:R:F521	R:R:T286	6.49	No	No	0	7	8
24	R:R:L289	R:R:L293	4.15	No	Yes	0	7	4
25	R:R:R294	R:R:Y290	8.23	No	Yes	1	7	6
26	R:R:F300	R:R:Y290	4.13	Yes	Yes	1	5	6
27	R:R:K307	R:R:Y290	4.78	No	Yes	1	6	6
28	R:R:V310	R:R:Y290	12.62	No	Yes	0	6	6
29	R:R:F521	R:R:Y290	4.13	No	Yes	0	7	6
30	R:R:L293	R:R:R297	6.07	Yes	Yes	1	4	6
31	R:R:F300	R:R:L293	12.18	Yes	Yes	1	5	4
32	R:R:K307	R:R:R294	4.95	No	No	1	6	7
33	R:R:R297	R:R:R299	6.4	Yes	No	1	6	6
34	R:R:F300	R:R:R297	4.28	Yes	Yes	1	5	6
35	R:R:P527	R:R:R297	8.65	No	Yes	0	6	6
36	R:R:F300	R:R:R299	6.41	Yes	No	1	5	6
37	R:R:E303	R:R:R299	15.12	No	No	1	7	6
38	R:R:E303	R:R:F300	4.66	No	Yes	1	7	5
39	R:R:F300	R:R:P306	7.22	Yes	No	1	5	6
40	R:R:F300	R:R:Y525	5.16	Yes	Yes	1	5	6
41	R:R:E303	R:R:P306	6.29	No	No	1	7	6
42	R:R:D304	R:R:Y378	5.75	No	Yes	0	4	6
43	R:R:P306	R:R:Y525	11.13	No	Yes	1	6	6
44	R:R:F379	R:R:K307	9.93	No	No	0	5	6
45	R:R:H362	R:R:I308	5.3	Yes	No	0	7	8
46	R:R:E359	R:R:H309	9.85	No	Yes	0	9	8
47	R:R:H309	R:R:W520	7.41	Yes	No	0	8	7
48	R:R:H309	R:R:Y525	5.44	Yes	Yes	0	8	6
49	H:H:?1	R:R:H309	5.64	Yes	Yes	0	0	8
50	R:R:A311	R:R:W355	7.78	No	Yes	0	8	9
51	R:R:E359	R:R:L312	3.98	No	No	0	9	8
52	R:R:C351	R:R:S315	3.44	Yes	No	3	7	7
53	R:R:S315	R:R:W387	3.71	No	Yes	3	7	9
54	R:R:F348	R:R:L318	12.18	No	No	0	7	5
55	R:R:L319	R:R:L349	4.15	No	No	0	8	7
56	L:L:?4	R:R:L319	3.84	Yes	No	0	0	8
57	R:R:N320	R:R:N510	12.26	Yes	No	2	7	9
58	R:R:F323	R:R:V327	7.87	Yes	No	0	9	5
59	R:R:F323	R:R:F345	8.57	Yes	Yes	2	9	8
60	L:L:?4	R:R:F323	14.36	Yes	Yes	2	0	9
61	R:R:N326	R:R:R341	6.03	No	Yes	0	6	6
62	R:R:F345	R:R:N326	8.46	Yes	No	0	8	6
63	R:R:E418	R:R:S331	10.06	Yes	No	0	3	4
64	R:R:A337	R:R:R341	4.15	No	Yes	0	2	6
65	R:R:C338	R:R:C420	7.28	No	No	0	9	9
66	R:R:N401	R:R:W339	6.78	No	No	0	5	4
67	R:R:W339	R:R:Y403	9.65	No	Yes	0	4	9
68	R:R:C420	R:R:R341	8.36	No	Yes	0	9	6
69	R:R:A343	R:R:Y403	5.34	No	Yes	0	5	9
70	R:R:F348	R:R:V344	3.93	No	No	0	7	4
71	R:R:F345	R:R:W421	7.02	Yes	Yes	2	8	8
72	L:L:?4	R:R:F345	3.38	Yes	Yes	2	0	8
73	R:R:H346	R:R:L350	9	Yes	No	0	9	9
74	R:R:H346	R:R:Y403	9.8	Yes	Yes	0	9	9
75	R:R:F422	R:R:H346	14.71	Yes	Yes	0	7	9
76	R:R:H346	R:R:T434	5.48	Yes	No	0	9	7
77	R:R:F348	R:R:Y347	4.13	No	Yes	0	7	7
78	R:R:C351	R:R:Y347	8.06	Yes	Yes	3	7	7
79	R:R:P390	R:R:Y347	5.56	Yes	Yes	3	9	7
80	R:R:V394	R:R:Y347	3.79	No	Yes	0	9	7
81	R:R:F353	R:R:L349	3.65	Yes	No	0	8	7
82	R:R:L350	R:R:Y438	5.86	No	Yes	0	9	8
83	R:R:C351	R:R:W387	5.22	Yes	Yes	3	7	9
84	R:R:C351	R:R:P390	3.77	Yes	Yes	3	7	9
85	R:R:F353	R:R:Y438	4.13	Yes	Yes	0	8	8
86	R:R:F353	R:R:F439	8.57	Yes	Yes	4	8	6
87	R:R:F353	R:R:W490	6.01	Yes	Yes	0	8	9
88	R:R:F353	R:R:I494	5.02	Yes	Yes	4	8	5
89	R:R:G386	R:R:T354	3.64	No	No	0	7	6
90	R:R:P390	R:R:T354	5.25	Yes	No	0	9	6
91	R:R:T354	R:R:Y438	7.49	No	Yes	0	6	8
92	R:R:L358	R:R:W355	7.97	No	Yes	0	7	9
93	R:R:G386	R:R:W355	4.22	No	Yes	0	7	9
94	R:R:W355	R:R:W387	12.18	Yes	Yes	0	9	9
95	R:R:M356	R:R:W490	5.82	No	Yes	0	9	9
96	H:H:?1	R:R:M356	4.96	Yes	No	0	0	9
97	R:R:L358	R:R:L382	5.54	No	No	0	7	7
98	R:R:A360	R:R:V449	3.39	No	No	0	8	7
99	H:H:?1	R:R:A360	4.14	Yes	No	0	0	8
100	R:R:F361	R:R:L365	6.09	No	Yes	0	5	6
101	R:R:H362	R:R:L366	9	Yes	No	0	7	6
102	R:R:H362	R:R:Y378	7.62	Yes	Yes	0	7	6
103	H:H:?1	R:R:H362	4.51	Yes	Yes	0	0	7
104	R:R:L363	R:R:L479	5.54	No	No	0	8	6
105	H:H:?1	R:R:L363	8.49	Yes	No	0	0	8
106	R:R:L365	R:R:Y364	3.52	Yes	No	0	6	8
107	R:R:V368	R:R:Y364	8.83	No	No	0	7	8
108	R:R:R369	R:R:Y364	5.14	Yes	No	0	6	8
109	R:R:F375	R:R:L365	4.87	No	Yes	0	4	6
110	R:R:L365	R:R:Y378	4.69	Yes	Yes	0	6	6
111	R:R:N372	R:R:R369	3.62	No	Yes	0	6	6
112	R:R:F375	R:R:R369	4.28	No	Yes	0	4	6
113	R:R:F371	R:R:V370	3.93	No	No	0	7	8
114	R:R:G376	R:R:Y374	4.35	No	No	0	5	5
115	R:R:L382	R:R:Y378	11.72	No	Yes	0	7	6
116	R:R:F379	R:R:S383	3.96	No	No	0	5	5
117	R:R:S383	R:R:W387	4.94	No	Yes	0	5	9
118	R:R:M393	R:R:Y438	4.79	No	Yes	0	7	8
119	R:R:V394	R:R:Y403	5.05	No	Yes	0	9	9
120	R:R:G396	R:R:I395	3.53	No	No	0	5	4
121	R:R:S402	R:R:T397	6.4	No	No	0	4	7
122	R:R:T397	R:R:Y403	3.75	No	Yes	0	7	9
123	R:R:T397	R:R:T434	4.71	No	No	0	7	7
124	R:R:F422	R:R:S402	5.28	Yes	No	0	7	4
125	R:R:A430	R:R:S402	3.42	No	No	0	5	4
126	R:R:E418	R:R:L405	5.3	Yes	No	0	3	4
127	R:R:W421	R:R:Y406	9.65	Yes	No	0	8	2
128	R:R:E424	R:R:Y406	6.73	No	No	0	4	2
129	R:R:T407	R:R:T415	4.71	No	No	5	3	4
130	R:R:E418	R:R:T407	4.23	Yes	No	5	3	3
131	R:R:N413	R:R:R409	4.82	No	No	0	4	3
132	R:R:D410	R:R:S416	8.83	No	No	0	4	2
133	R:R:E412	R:R:R414	20.93	No	No	0	3	4
134	R:R:E418	R:R:T415	5.64	Yes	No	5	3	4
135	R:R:L417	R:R:L419	4.15	No	No	0	3	5
136	R:R:F422	R:R:W421	15.03	Yes	Yes	2	7	8
137	R:R:L431	R:R:W421	3.42	No	Yes	2	6	8
138	L:L:?4	R:R:W421	3.95	Yes	Yes	2	0	8
139	R:R:F422	R:R:L431	8.53	Yes	No	2	7	6
140	R:R:G425	R:R:T426	3.64	No	No	0	3	3
141	R:R:T427	R:R:Y429	3.75	No	No	0	4	5
142	R:R:H436	R:R:Y432	8.71	Yes	No	0	6	7
143	R:R:H436	R:R:V435	5.54	Yes	No	0	6	8
144	R:R:H436	R:R:I494	6.63	Yes	Yes	4	6	5
145	R:R:F495	R:R:H436	10.18	No	Yes	4	6	6
146	R:R:T442	R:R:Y438	3.75	No	Yes	0	7	8
147	R:R:F439	R:R:G491	4.52	Yes	No	0	6	6
148	R:R:F439	R:R:I494	6.28	Yes	Yes	4	6	5
149	H:H:?1	R:R:F439	6.41	Yes	Yes	0	0	6
150	R:R:F495	R:R:L440	4.87	No	No	0	6	3
151	H:H:?1	R:R:T442	3.88	Yes	No	0	0	7
152	R:R:F443	R:R:M447	8.71	No	No	0	7	3
153	R:R:F443	R:R:G487	4.52	No	No	0	7	9
154	R:R:L450	R:R:S483	6.01	No	No	0	7	6
155	R:R:I457	R:R:N472	4.25	No	No	0	7	4
156	R:R:I457	R:R:V476	9.22	No	No	0	7	5
157	R:R:F458	R:R:R473	4.28	No	No	0	3	4
158	R:R:F458	R:R:L477	3.65	No	No	0	3	7
159	R:R:R473	R:R:S461	6.59	No	No	0	4	5
160	R:R:R469	R:R:V466	10.46	No	No	0	3	3
161	H:H:?1	R:R:S483	7.9	Yes	No	0	0	6
162	R:R:F509	R:R:T489	9.08	No	No	0	5	9
163	R:R:Q513	R:R:W490	7.67	No	Yes	0	9	9
164	L:L:?4	R:R:W490	3.95	Yes	Yes	0	0	9
165	R:R:F509	R:R:L492	3.65	No	No	0	5	7
166	R:R:F495	R:R:I494	3.77	No	Yes	4	6	5
167	R:R:P497	R:R:T496	3.5	No	No	0	5	7
168	R:R:F506	R:R:T496	3.89	No	No	0	9	7
169	R:R:G499	R:R:L498	3.42	No	Yes	0	5	4
170	R:R:F506	R:R:L498	3.65	No	Yes	0	9	4
171	R:R:S501	R:R:T502	4.8	No	No	0	5	7
172	R:R:F506	R:R:T502	5.19	No	No	0	9	7
173	R:R:F509	R:R:I505	6.28	No	No	0	5	7
174	L:L:?4	R:R:N510	6.67	Yes	No	2	0	9
175	R:R:L524	R:R:W520	7.97	No	No	0	6	7
176	R:R:F521	R:R:Y525	10.32	No	Yes	0	7	6
177	R:R:L524	R:R:Y525	17.58	No	Yes	0	6	6
178	R:R:L389	R:R:P390	3.28	No	Yes	0	3	9
179	R:R:L526	R:R:P527	3.28	No	No	0	4	6
180	R:R:F361	R:R:F445	3.22	No	No	0	5	5
181	R:R:V453	R:R:V476	3.21	No	No	0	7	5
182	R:R:V454	R:R:V476	3.21	No	No	0	5	5
183	H:H:?1	R:R:F443	3.2	Yes	No	0	0	7
184	R:R:T464	R:R:V466	3.17	No	No	0	4	3
185	R:R:M447	R:R:S484	3.07	No	No	0	3	5
186	R:R:I433	R:R:T434	3.04	No	No	0	5	7
187	R:R:I523	R:R:T522	3.04	No	No	0	5	6
188	R:R:F445	R:R:G446	3.01	No	No	0	5	9
189	R:R:L268	R:R:S416	3	Yes	No	0	9	2
190	R:R:L419	R:R:V327	2.98	No	No	0	5	5
191	R:R:L363	R:R:V453	2.98	No	No	0	8	7
192	R:R:L289	R:R:T522	2.95	No	No	0	7	6
193	R:R:L482	R:R:T478	2.95	No	No	0	8	7
194	R:R:L485	R:R:T489	2.95	No	No	0	8	9
195	R:R:A305	R:R:H309	2.93	No	Yes	0	7	8
196	R:R:A305	R:R:H362	2.93	No	Yes	0	7	7
197	R:R:G398	R:R:Y403	2.9	No	Yes	0	6	9
198	L:L:?4	R:R:L498	2.88	Yes	Yes	0	0	4
199	R:R:I267	R:R:L268	2.85	No	Yes	0	3	9
200	R:R:I517	R:R:L283	2.85	No	Yes	0	8	7
201	R:R:L431	R:R:M428	2.83	No	No	0	6	5
202	R:R:C518	R:R:F285	2.79	No	No	0	8	4
203	R:R:L268	R:R:L417	2.77	Yes	No	0	9	3
204	R:R:L268	R:R:L498	2.77	Yes	Yes	0	9	4
205	R:R:L312	R:R:L316	2.77	No	No	0	8	8
206	R:R:L380	R:R:L384	2.77	No	No	0	5	4
207	R:R:L450	R:R:L480	2.77	No	No	0	7	4
208	R:R:R297	R:R:S296	2.64	Yes	No	0	6	5
209	R:R:R341	R:R:S329	2.64	Yes	No	0	6	5
210	R:R:R414	R:R:T264	2.59	No	No	0	4	5
211	R:R:R369	R:R:T373	2.59	Yes	No	0	6	5
212	R:R:H377	R:R:L380	2.57	No	No	0	5	5
213	R:R:F458	R:R:I457	2.51	No	No	0	3	7
214	R:R:F292	R:R:L293	2.44	No	Yes	0	3	4
215	R:R:I408	R:R:Y406	2.42	No	No	0	6	2
216	R:R:Q273	R:R:R270	2.34	No	No	0	4	4
217	R:R:G313	R:R:G314	2.11	No	No	0	6	3
218	R:R:G388	R:R:P390	2.03	No	Yes	0	8	9
219	R:R:A274	R:R:G275	1.95	No	No	0	6	8
220	R:R:A507	R:R:G275	1.95	No	No	0	6	8
221	R:R:A337	R:R:G333	1.95	No	No	0	2	1
222	R:R:A391	R:R:G388	1.95	No	No	0	5	8
223	R:R:G275	R:R:S511	1.86	No	No	0	8	8
224	R:R:G330	R:R:S331	1.86	No	No	0	6	4
225	R:R:G386	R:R:V385	1.84	No	No	0	7	4
226	R:R:G470	R:R:V466	1.84	No	No	0	4	3
227	R:R:G487	R:R:V486	1.84	No	No	0	9	8
228	R:R:G357	R:R:T442	1.82	No	No	0	6	7
229	R:R:G314	R:R:I287	1.76	No	No	0	3	6
230	R:R:G277	R:R:M280	1.75	No	Yes	0	5	6
231	R:R:G313	R:R:L283	1.71	No	Yes	0	6	7
232	R:R:A352	R:R:S315	1.71	No	No	0	5	7
233	R:R:G481	R:R:L480	1.71	No	No	0	7	4
234	R:R:C519	R:R:V515	1.71	No	No	0	5	6
235	R:R:A367	R:R:V453	1.7	No	No	0	6	7
236	R:R:G328	R:R:Q273	1.64	No	No	0	3	4
237	R:R:S263	R:R:V265	1.62	No	No	0	1	3
238	R:R:A507	R:R:I271	1.62	No	No	0	6	8
239	R:R:S272	R:R:V503	1.62	No	No	0	8	6
240	R:R:S484	R:R:V488	1.62	No	No	0	5	6
241	R:R:S263	R:R:T264	1.6	No	No	0	1	5
242	R:R:C338	R:R:L405	1.59	No	No	0	9	4
243	R:R:G437	R:R:H436	1.59	No	Yes	0	5	6
244	R:R:T426	R:R:T427	1.57	No	No	0	3	4
245	R:R:A322	R:R:N326	1.56	No	No	0	5	6
246	R:R:I395	R:R:S399	1.55	No	No	0	4	5
247	R:R:K332	R:R:S329	1.53	No	No	0	5	5
248	R:R:K456	R:R:V370	1.52	No	No	0	6	8
249	R:R:I505	R:R:T502	1.52	No	No	0	7	7
250	R:R:F345	R:R:G342	1.51	Yes	No	0	8	9
251	R:R:G404	R:R:R423	1.5	No	No	0	5	5
252	R:R:K474	R:R:T478	1.5	No	No	0	5	7
253	R:R:L321	R:R:V325	1.49	No	No	0	5	4
254	R:R:L452	R:R:V368	1.49	No	No	0	4	7
255	R:R:L452	R:R:V448	1.49	No	No	0	4	4
256	R:R:G404	R:R:Y403	1.45	No	Yes	0	5	9
257	R:R:K471	R:R:K475	1.44	No	No	0	4	6
258	R:R:I267	R:R:L500	1.43	No	No	0	3	3
259	R:R:K456	R:R:L460	1.41	No	No	0	6	5
260	R:R:K475	R:R:N472	1.4	No	No	0	6	4
261	R:R:A284	R:R:F317	1.39	No	No	0	3	6
262	R:R:H377	R:R:K381	1.31	No	No	0	5	7
263	R:R:R409	R:R:T407	1.29	No	No	0	3	3
264	R:R:R462	R:R:T459	1.29	No	No	0	3	5
265	R:R:F516	R:R:I517	1.26	No	No	0	6	8
266	R:R:I433	R:R:Y429	1.21	No	No	0	5	5
267	R:R:E468	R:R:R473	1.16	No	No	0	4	4
268	R:R:H266	R:R:R270	1.13	No	No	0	1	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L268	2.8475	4	0	9
2	R:R:M280	4.878	5	0	6
3	R:R:L283	3.2125	4	0	7
4	R:R:Y290	6.778	5	1	6
5	R:R:L293	6.21	4	1	4
6	R:R:R297	5.608	5	1	6
7	R:R:F300	6.29143	7	1	5
8	R:R:H309	6.254	5	0	8
9	R:R:N320	7.555	4	2	7
10	R:R:F323	8.334	5	2	9
11	R:R:R341	5.295	4	0	6
12	R:R:F345	5.788	5	2	8
13	R:R:H346	9.7475	4	0	9
14	R:R:Y347	5.385	4	3	7
15	R:R:C351	5.1225	4	3	7
16	R:R:F353	5.476	5	4	8
17	R:R:W355	8.0375	4	0	9
18	R:R:H362	5.872	5	0	7
19	R:R:L365	4.7925	4	0	6
20	R:R:R369	3.9075	4	0	6
21	R:R:Y378	7.445	4	0	6
22	R:R:W387	6.5125	4	3	9
23	R:R:P390	3.978	5	3	9
24	R:R:Y403	5.42	7	0	9
25	R:R:E418	6.3075	4	5	3
26	R:R:W421	7.814	5	2	8
27	R:R:F422	10.8875	4	2	7
28	R:R:H436	6.53	5	4	6
29	R:R:Y438	5.204	5	0	8
30	R:R:F439	6.445	4	4	6
31	R:R:W490	5.8625	4	0	9
32	R:R:I494	5.425	4	4	5
33	R:R:L498	3.18	4	0	4
34	R:R:Y525	9.926	5	1	6
35	L:L:?4	5.57571	7	2	0
36	H:H:?1	5.45889	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q273	R:R:T269	10.47	5.67	No	No	0	4	6
2	R:R:T269	R:R:V327	13.0454	4.76	No	No	0	6	5
3	R:R:L268	R:R:S416	14.6739	3	Yes	No	0	9	2
4	R:R:I271	R:R:V503	18.1432	6.14	No	No	0	8	6
5	R:R:S272	R:R:V503	20.6655	1.62	No	No	0	8	6
6	R:R:F323	R:R:S272	23.1702	5.28	Yes	No	0	9	8
7	L:L:?4	R:R:F323	32.171	14.36	Yes	Yes	2	0	9
8	L:L:?4	R:R:L498	43.7649	2.88	Yes	Yes	0	0	4
9	R:R:L268	R:R:L498	21.7276	2.77	Yes	Yes	0	9	4
10	R:R:C276	R:R:F323	11.7887	5.59	No	Yes	0	7	9
11	R:R:N320	R:R:N510	13.0277	12.26	Yes	No	2	7	9
12	L:L:?4	R:R:N510	30.9408	6.67	Yes	No	2	0	9
13	R:R:A507	R:R:I271	13.0454	1.62	No	No	0	6	8
14	R:R:A507	R:R:G275	10.47	1.95	No	No	0	6	8
15	R:R:N510	R:R:S279	16.0634	5.96	No	No	2	9	9
16	R:R:G514	R:R:S279	15.3642	3.71	No	No	0	9	9
17	R:R:M280	R:R:N320	14.3464	4.21	Yes	Yes	0	6	7
18	R:R:C518	R:R:T286	11.8064	3.38	No	No	0	8	8
19	R:R:F521	R:R:T286	14.1163	6.49	No	No	0	7	8
20	R:R:F521	R:R:Y525	22.2763	10.32	No	Yes	0	7	6
21	R:R:H309	R:R:Y525	58.8017	5.44	Yes	Yes	0	8	6
22	H:H:?1	R:R:H309	62.8374	5.64	Yes	Yes	0	0	8
23	H:H:?1	R:R:M356	73.5994	4.96	Yes	No	0	0	9
24	R:R:M356	R:R:W490	73.6614	5.82	No	Yes	0	9	9
25	L:L:?4	R:R:W490	100	3.95	Yes	Yes	0	0	9
26	R:R:G514	R:R:L283	13.2401	3.42	No	Yes	0	9	7
27	R:R:F300	R:R:L293	11.3638	12.18	Yes	Yes	1	5	4
28	R:R:F300	R:R:Y525	31.6311	5.16	Yes	Yes	1	5	6
29	R:R:F300	R:R:Y290	11.7267	4.13	Yes	Yes	1	5	6
30	R:R:F521	R:R:Y290	10.2752	4.13	No	Yes	0	7	6
31	R:R:K307	R:R:Y290	10.4788	4.78	No	Yes	1	6	6
32	R:R:H362	R:R:Y378	40.1363	7.62	Yes	Yes	0	7	6
33	H:H:?1	R:R:H362	39.6053	4.51	Yes	Yes	0	0	7
34	R:R:S383	R:R:W387	10.6558	4.94	No	Yes	0	5	9
35	R:R:P390	R:R:T354	19.8248	5.25	Yes	No	0	9	6
36	R:R:T354	R:R:Y438	30.7815	7.49	No	Yes	0	6	8
37	R:R:F353	R:R:Y438	24.9226	4.13	Yes	Yes	0	8	8
38	R:R:F353	R:R:W490	27.9936	6.01	Yes	Yes	0	8	9
39	R:R:G386	R:R:T354	11.709	3.64	No	No	0	7	6
40	R:R:V394	R:R:Y347	10.4169	3.79	No	Yes	0	9	7
41	R:R:V394	R:R:Y403	11.0187	5.05	No	Yes	0	9	9
42	R:R:H346	R:R:Y403	22.0816	9.8	Yes	Yes	0	9	9
43	R:R:F422	R:R:H346	23.9756	14.71	Yes	Yes	0	7	9
44	R:R:F422	R:R:W421	26.4448	15.03	Yes	Yes	2	7	8
45	L:L:?4	R:R:W421	24.3207	3.95	Yes	Yes	2	0	8
46	L:L:?4	R:R:F345	28.3476	3.38	Yes	Yes	2	0	8
47	R:R:F345	R:R:N326	36.1536	8.46	Yes	No	0	8	6
48	R:R:N326	R:R:R341	32.3834	6.03	No	Yes	0	6	6
49	R:R:E418	R:R:L405	15.6032	5.3	Yes	No	0	3	4
50	R:R:C338	R:R:L405	17.7626	1.59	No	No	0	9	4
51	R:R:C338	R:R:C420	19.9044	7.28	No	No	0	9	9
52	R:R:C420	R:R:R341	22.0285	8.36	No	Yes	0	9	6
53	R:R:H346	R:R:L350	20.1345	9	Yes	No	0	9	9
54	R:R:L350	R:R:Y438	20.7186	5.86	No	Yes	0	9	8
55	R:R:H346	R:R:T434	14.1428	5.48	Yes	No	0	9	7
56	R:R:L365	R:R:Y378	34.8349	4.69	Yes	Yes	0	6	6
57	H:H:?1	R:R:L363	29.7371	8.49	Yes	No	0	0	8
58	R:R:L365	R:R:Y364	16.5324	3.52	Yes	No	0	6	8
59	R:R:S416	R:R:T264	10.5673	6.4	No	No	0	2	5
60	R:R:I433	R:R:T434	12.2931	3.04	No	No	0	5	7
61	R:R:T442	R:R:Y438	28.2768	3.75	No	Yes	0	7	8
62	H:H:?1	R:R:T442	28.9495	3.88	Yes	No	0	0	7
63	H:H:?1	R:R:F443	12.7356	3.2	Yes	No	0	0	7
64	R:R:I457	R:R:V476	18.8247	9.22	No	No	0	7	5
65	R:R:V453	R:R:V476	22.5861	3.21	No	No	0	7	5
66	R:R:L363	R:R:V453	26.2855	2.98	No	No	0	8	7
67	R:R:F458	R:R:I457	10.6204	2.51	No	No	0	3	7
68	R:R:I505	R:R:T502	10.4523	1.52	No	No	0	7	7
69	R:R:F506	R:R:T502	14.5588	5.19	No	No	0	9	7
70	R:R:F506	R:R:L498	20.5947	3.65	No	Yes	0	9	4
71	R:R:F323	R:R:V327	17.7449	7.87	Yes	No	0	9	5
72	R:R:F345	R:R:W421	11.0098	7.02	Yes	Yes	2	8	8
73	R:R:F323	R:R:F345	10.5496	8.57	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F323	R:R:S272	5.28	2	Yes	No	9	8	1	2
R:R:C276	R:R:N320	6.3	0	No	Yes	7	7	2	2
R:R:C276	R:R:F323	5.59	0	No	Yes	7	9	2	1
R:R:N320	R:R:S279	7.45	2	Yes	No	7	9	2	2
R:R:N510	R:R:S279	5.96	2	No	No	9	9	1	2
R:R:L319	R:R:L349	4.15	0	No	No	8	7	1	2
L:L:?4	R:R:L319	3.84	2	Yes	No	0	8	0	1
R:R:N320	R:R:N510	12.26	2	Yes	No	7	9	2	1
R:R:F323	R:R:V327	7.87	2	Yes	No	9	5	1	2
R:R:F323	R:R:F345	8.57	2	Yes	Yes	9	8	1	1
L:L:?4	R:R:F323	14.36	2	Yes	Yes	0	9	0	1
R:R:F345	R:R:N326	8.46	2	Yes	No	8	6	1	2
R:R:F345	R:R:W421	7.02	2	Yes	Yes	8	8	1	1
L:L:?4	R:R:F345	3.38	2	Yes	Yes	0	8	0	1
R:R:F353	R:R:L349	3.65	4	Yes	No	8	7	2	2
R:R:F353	R:R:W490	6.01	4	Yes	Yes	8	9	2	1
R:R:M356	R:R:W490	5.82	0	No	Yes	9	9	2	1
R:R:W421	R:R:Y406	9.65	2	Yes	No	8	2	1	2
R:R:F422	R:R:W421	15.03	2	Yes	Yes	7	8	2	1
R:R:L431	R:R:W421	3.42	2	No	Yes	6	8	2	1
L:L:?4	R:R:W421	3.95	2	Yes	Yes	0	8	0	1
R:R:F422	R:R:L431	8.53	2	Yes	No	7	6	2	2
R:R:Q513	R:R:W490	7.67	0	No	Yes	9	9	2	1
L:L:?4	R:R:W490	3.95	2	Yes	Yes	0	9	0	1
R:R:G499	R:R:L498	3.42	0	No	Yes	5	4	2	1
R:R:F506	R:R:L498	3.65	0	No	Yes	9	4	2	1
L:L:?4	R:R:N510	6.67	2	Yes	No	0	9	0	1
L:L:?4	R:R:L498	2.88	2	Yes	Yes	0	4	0	1
R:R:L268	R:R:L498	2.77	0	Yes	Yes	9	4	2	1
R:R:F345	R:R:G342	1.51	2	Yes	No	8	9	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7D77_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	243
Number of Links	268
Number of Hubs	36
Number of Links mediated by Hubs	137
Number of Communities	5
Number of Nodes involved in Communities	32
Number of Links involved in Communities	42

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	30521
Length Of Smallest Path	3
Average Path Length	9.98427
Length of Longest Path	22
Minimum Path Strength	1.42
Average Path Strength	5.59773
Maximum Path Strength	14.87
Minimum Path Correlation	0.7
Average Path Correlation	0.91887
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	51.9143
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.9477
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • negative regulation of DNA-binding transcription factor activity • RNA metabolic process • negative regulation of CREB transcription factor activity • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • negative regulation of molecular function • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of molecular function • regulation of gene expression • biosynthetic process • regulation of DNA-binding transcription factor activity • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • cellular developmental process • hemopoiesis • B cell activation • cell activation • cell development • mononuclear cell differentiation • lymphocyte differentiation • lymphocyte activation • leukocyte activation • B cell differentiation • cell differentiation • immune system process • leukocyte differentiation • cell surface receptor signaling pathway • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of biological process • regulation of signal transduction • regulation of non-canonical NF-kappaB signal transduction • negative regulation of cell communication • regulation of intracellular signal transduction • negative regulation of cellular process • negative regulation of non-canonical NF-kappaB signal transduction • regulation of signaling • negative regulation of response to stimulus • non-canonical NF-kappaB signal transduction • negative regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • intracellular vesicle • endomembrane system • specific granule membrane • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HCY
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	HCY
Name	Hydrocortisone
Synonyms	Hydrocortisonum
Identifier
Formula	C21 H30 O5
Molecular Weight	362.46
SMILES
PubChem	5754
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	7
Total Bonds	59
Total Aromatic Bonds	0


Code	PLM
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	PLM
Name	Palmitic Acid
Synonyms	Palmitinsäure
Identifier
Formula	C16 H32 O2
Molecular Weight	256.424
SMILES
PubChem	985
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q86Y34
Sequence	>7D77_nogp_Chain_R S T V H I L T R I S Q A G C G V S M I F L A F T I I L Y A F L R L S R E R F K S E D A P K I H V A L G G S L F L L N L A F L V N V G S G S K G S D A A C W A R G A V F H Y F L L C A F T W M G L E A F H L Y L L A V R V F N T Y F G H Y F L K L S L V G W G L P A L M V I G T G S A N S Y G L Y T I R D R E N R T S L E L C W F R E G T T M Y A L Y I T V H G Y F L I T F L F G M V V L A L V V W K I F T L S R A T A V K E R G K N R K K V L T L L G L S S L V G V T W G L A I F T P L G L S T V Y I F A L F N S L Q G V F I C C W F T I L Y L P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7D76	B2	Adhesion	Adhesion	ADGRG3	Homo sapiens	Beclomethasone	-	Go/β1/γ2	3.1	2021-02-03	doi.org/10.1038/s41586-020-03083-w
	7D76 (No Gprot)	B2	Adhesion	Adhesion	ADGRG3	Homo sapiens	Beclomethasone	-		3.1	2021-02-03	doi.org/10.1038/s41586-020-03083-w
	7D77	B2	Adhesion	Adhesion	ADGRG3	Homo sapiens	Hydrocortisone	-	Go/β1/γ2	2.9	2021-02-03	doi.org/10.1038/s41586-020-03083-w
	7D77 (No Gprot)	B2	Adhesion	Adhesion	ADGRG3	Homo sapiens	Hydrocortisone	-		2.9	2021-02-03	doi.org/10.1038/s41586-020-03083-w

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