Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:D48 4.0054299
2R:R:F55 5.85254179
3R:R:V57 4.148555
4R:R:H58 5.066558
5R:R:I70 6.525454
6R:R:R78 9.011676174
7R:R:E80 6.0025408
8R:R:L96 3.235409
9R:R:R104 10.085405
10R:R:I105 5.8075407
11R:R:D107 6.025458
12R:R:C109 4.71457
13R:R:I127 5.90254213
14R:R:S157 5.73254175
15R:R:I168 4.78754116
16R:R:L169 3.63406
17R:R:L171 3.808595
18R:R:Y179 8.066177
19R:R:P184 3.034325
20R:R:Y192 6.584116
21R:R:F195 7.625408
22R:R:R197 7.234129
23R:R:P200 3.66254127
24R:R:F204 4.74254125
25R:R:Q205 9.3854229
26R:R:M209 4.10254227
27R:R:W218 6.132509
28R:R:Y220 5.2125409
29R:R:T223 3.145406
30R:R:E227 9.0125406
31R:R:K233 5.475404
32R:R:V235 2.98405
33R:R:F286 4.2125227
34R:R:D291 5.128504
35R:R:L296 4.2475425
36R:R:K300 7.5375423
37R:R:Q304 5.265424
38R:R:W310 4.215626
39R:R:S313 4.4925228
40R:R:W316 4.14408
41R:R:H326 5.6275423
42R:R:I329 4.19624
43R:R:Y349 8.9025407
44R:R:F350 6.018586
45R:R:W363 8.14455
46R:R:F364 4.22754345
47R:R:Y367 6.134586
48R:R:W368 5.8085348
49R:R:N371 6.805483
50R:R:Y402 4.508584
51R:R:F410 5.0475407
52R:R:I412 4.525438
53R:R:Y416 5.594537
54R:R:V436 3.33754293
55R:R:C437 3.536507
56R:R:M440 3.26403
57R:R:R453 4.692505
58R:R:F457 7.098509
59R:R:D472 8.2454128
60R:R:F480 4.77405
61R:R:Q481 5.944508
62R:R:Y482 7.964336
63R:R:L502 2.8625406
64R:R:R516 6.07754363
65R:R:T535 5.24373
66R:R:Q567 7.48254135
67R:R:R568 3.6275407
68R:R:D578 3.91754134
69R:R:W586 10.2054185
70R:R:P594 4.305407
71R:R:T618 3.5925409
72R:R:T643 4.21254187
73R:R:I647 6.194188
74R:R:K649 3.36405
75R:R:R658 5.2254428
76R:R:R659 4.33754438
77R:R:F661 7.8454426
78R:R:Y670 5.12254236
79R:R:T675 3.0125408
80R:R:I710 2.706507
81R:R:R744 5.2506
82R:R:Q755 7.29254437
83R:R:E786 4.42254419
84R:R:Y789 12.89254476
85R:R:W801 4.16509
86R:R:E816 6.70754456
87R:R:M829 3.032508
88R:R:Y841 7.542509
89R:R:M842 6.42754473
90S:S:R44 5.37254254
91S:S:D48 4.0054489
92S:S:F55 6.124199
93S:S:V57 4.148565
94S:S:H58 4.718568
95S:S:I70 6.1925464
96S:S:R78 9.596676194
97S:S:E80 6.0025408
98S:S:L96 3.8275409
99S:S:R104 9.814255
100S:S:I105 6.175407
101S:S:D107 6.0325468
102S:S:C109 4.0075467
103S:S:I127 4.3665203
104S:S:K146 6.4885252
105S:S:S157 5.73254195
106S:S:I163 5.3425495
107S:S:V165 5.225406
108S:S:I168 3.655496
109S:S:L169 3.63406
110S:S:L171 3.00254115
111S:S:Y179 8.066197
112S:S:P184 3.034525
113S:S:Y192 6.58496
114S:S:F195 7.625408
115S:S:R197 7.234149
116S:S:P200 3.66254147
117S:S:Q205 9.3854269
118S:S:M209 4.10254267
119S:S:W218 6.548509
120S:S:Y220 6.3056539
121S:S:E227 8.6925406
122S:S:K233 5.475404
123S:S:F286 4.2125267
124S:S:D291 5.128504
125S:S:L296 4.302515
126S:S:K300 8.555413
127S:S:Q304 5.265414
128S:S:W310 4.564516
129S:S:S313 4.4925268
130S:S:W316 5.3565548
131S:S:P322 2.9975403
132S:S:H326 5.23667613
133S:S:I329 4.19614
134S:S:Y349 8.9025407
135S:S:F350 6.0185106
136S:S:W363 8.125465
137S:S:F364 4.27754555
138S:S:Y367 6.1345106
139S:S:W368 6.97254558
140S:S:Y402 3.968336104
141S:S:F410 5.3575407
142S:S:I412 4.525408
143S:S:Y416 5.5945507
144S:S:C437 3.3425407
145S:S:R453 4.9375405
146S:S:F457 7.098509
147S:S:F480 4.774155
148S:S:Q481 6.276578
149S:S:Y482 7.33754156
150S:S:L502 2.8625406
151S:S:M509 5.5975477
152S:S:W511 6.05833678
153S:S:P519 6.7425478
154S:S:Y553 5.4925567
155S:S:Q567 5.016505
156S:S:P589 4.66254584
157S:S:P594 5.1375407
158S:S:F612 3.94449
159S:S:T618 3.5925409
160S:S:R626 3.84667648
161S:S:R658 5.94598
162S:S:R659 4.01254608
163S:S:F661 7.8354596
164S:S:Y670 7.0354276
165S:S:T675 3408
166S:S:T677 2.0775409
167S:S:Q702 64628
168S:S:I710 2.935407
169S:S:D733 6.72754573
170S:S:E734 5.135406
171S:S:R744 5.5375406
172S:S:Q755 6.7454607
173S:S:Y789 14.9154286
174S:S:T793 3.85409
175S:S:F808 7.7825408
176S:S:E816 7.3354646
177S:S:K817 4.77754646
178S:S:T826 4.02254167
179S:S:M829 3.85408
180S:S:M842 11.97254283
181S:S:Y846 5.2425288
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I154 R:R:M418 10.4865.83NoNo076
2R:R:I177 R:R:M418 10.67224.37NoNo3166
3R:R:I177 R:R:S196 11.25154.64NoNo066
4R:R:F467 R:R:S196 13.15822.64NoNo086
5R:R:F467 R:R:V198 19.0472.62NoNo088
6R:R:F410 R:R:V198 19.41215.24YesNo078
7R:R:F410 R:R:K407 29.11133.72YesNo074
8R:R:K407 R:R:R78 28.92774.95NoYes044
9R:R:F55 R:R:R78 27.24385.34YesYes1794
10R:R:F55 R:R:L79 18.30046.09YesNo095
11R:R:F195 R:R:R197 93.1576.41YesYes089
12R:R:P201 R:R:R197 46.458511.53NoYes1289
13R:R:F204 R:R:P201 46.39832.89YesNo1258
14R:R:F204 R:R:P200 92.52952.89YesYes1257
15R:R:P200 R:R:V199 51.06563.53YesNo077
16R:R:F410 R:R:V199 50.72086.55YesNo077
17R:R:D472 R:R:R197 46.63128.34YesYes1289
18R:R:D472 R:R:F204 46.45087.17YesYes1285
19R:R:E80 R:R:Y349 14.11467.86YesYes087
20R:R:L83 R:R:Y349 15.4543.52NoYes057
21R:R:I105 R:R:L83 16.56142.85YesNo075
22R:R:N167 S:S:L171 13.14032.75NoYes1155
23R:R:I163 R:R:N167 13.05372.83NoNo1155
24R:R:I163 R:R:L186 91.5925.71NoNo058
25R:R:F195 R:R:L186 91.56179.74YesNo088
26S:S:L79 S:S:V57 10.01274.47NoYes055
27S:S:F55 S:S:L79 12.72216.09YesNo095
28S:S:F55 S:S:R78 15.60316.41YesYes1994
29S:S:K407 S:S:R78 18.58256.19NoYes044
30S:S:F410 S:S:K407 18.70454.96YesNo074
31S:S:F410 S:S:V198 13.98515.24YesNo078
32S:S:F467 S:S:V198 13.94972.62NoNo088
33S:S:F467 S:S:S196 15.87222.64NoNo086
34S:S:R453 S:S:S196 14.64045.27YesNo056
35S:S:L449 S:S:R453 14.56267.29NoYes065
36S:S:F194 S:S:L449 14.53717.31NoNo076
37S:S:D193 S:S:F194 14.46523.58NoNo077
38S:S:D193 S:S:R170 14.44158.34NoNo075
39S:S:L171 S:S:R170 14.41813.64YesNo055
40R:R:Q481 R:R:W511 10.49663.29YesNo088
41R:R:E331 R:R:W511 10.68833.27NoNo048
42R:R:E331 R:R:T484 11.64532.82NoNo043
43R:R:T484 R:R:Y482 12.40924.99NoYes036
44R:R:Y482 R:R:Y492 13.171511.91YesNo065
45R:R:F480 R:R:Y492 13.36184.13YesNo055
46R:R:F480 R:R:S318 14.3125.28YesNo055
47R:R:Q337 R:R:S318 14.50177.22NoNo055
48R:R:P338 R:R:Q337 31.72133.16NoNo045
49R:R:P338 R:R:Y477 39.73768.34NoNo049
50R:R:P200 R:R:Y477 48.29684.17YesNo079
51R:R:I163 R:R:Y192 78.56947.25NoYes1156
52S:S:R191 S:S:Y192 78.86599.26NoYes056
53R:R:R191 S:S:R191 78.81849.6NoNo055
54R:R:R191 R:R:Y192 78.78089.26NoYes056
55R:R:D314 R:R:Q205 16.399920.88NoYes089
56R:R:G317 R:R:Q337 17.71256.58NoNo065
57R:R:G317 R:R:W316 17.52441.41NoYes068
58R:R:A333 R:R:W316 16.57411.3NoYes078
59R:R:A333 R:R:W310 16.38561.3NoYes076
60S:S:I163 S:S:Y192 77.2147.25YesYes956
61S:S:I163 S:S:L186 77.95998.56YesNo058
62S:S:F195 S:S:L186 77.9899.74YesNo088
63S:S:F410 S:S:V199 21.16616.55YesNo077
64S:S:F195 S:S:R197 80.08826.41YesYes089
65S:S:P201 S:S:R197 80.03111.53NoYes1489
66S:S:F204 S:S:P201 80.29932.89NoNo1458
67S:S:F204 S:S:P200 80.26492.89NoYes1457
68S:S:P200 S:S:V199 21.28073.53YesNo077
69S:S:P200 S:S:Y477 1004.17YesNo079
70S:S:I336 S:S:Y477 49.39466.04NoNo069
71S:S:D314 S:S:I336 49.35732.8NoNo086
72S:S:D314 S:S:Q205 99.178420.88NoYes089
73S:S:P338 S:S:Y477 50.60468.34NoNo049
74S:S:D314 S:S:P338 49.93248.05NoNo084
75S:S:Q205 S:S:S313 33.41658.66YesYes2698
76S:S:M209 S:S:Q205 65.25574.08YesYes2679
77S:S:F286 S:S:M209 32.85446.22YesYes2677
78S:S:F286 S:S:V284 64.37232.62YesNo076
79S:S:T223 S:S:V284 96.09983.17NoNo066
80S:S:I250 S:S:T223 95.25954.56NoNo056
81S:S:F238 S:S:I250 94.41882.51NoNo065
82S:S:F286 S:S:S313 32.89885.28YesYes2678
83S:S:M209 S:S:V311 32.28073.04YesNo077
84S:S:V284 S:S:V311 32.1488.02NoNo067
85S:S:F238 S:S:V210 93.57773.93NoNo067
86S:S:Q207 S:S:V210 93.1572.87NoNo037
87S:S:D211 S:S:Q207 92.31539.14NoNo053
88S:S:D211 S:S:W498 91.89435.58NoNo055
89S:S:L502 S:S:W498 91.05215.69YesNo065
90S:S:I212 S:S:L502 89.7882.85NoYes086
91S:S:I212 S:S:I479 88.94474.42NoNo088
92S:S:I479 S:S:I495 88.10115.89NoNo088
93S:S:I495 S:S:Q481 86.38396.86NoYes088
94S:S:Q481 S:S:W511 81.29217.67YesYes788
95S:S:L309 S:S:W511 40.67827.97NoYes778
96S:S:L309 S:S:W218 40.25267.97NoYes079
97S:S:S521 S:S:W218 36.39213.71NoYes099
98S:S:P519 S:S:W511 39.37998.11YesYes788
99S:S:P519 S:S:R281 36.80847.21YesNo085
100S:S:R281 S:S:S521 36.37982.64NoNo059
101S:S:S521 S:S:Y220 71.90892.54NoYes099
102S:S:N279 S:S:Y220 61.5542.33NoYes069
103S:S:N279 S:S:T277 60.69054.39NoNo063
104S:S:D276 S:S:T277 58.96318.67NoNo043
105S:S:D276 S:S:Q252 58.09933.92NoNo046
106S:S:Q252 S:S:S222 54.63375.78NoNo168
107S:S:S222 S:S:V283 53.77864.85NoNo186
108S:S:V283 S:S:W310 45.97463.68NoYes166
109S:S:I295 S:S:W310 20.86322.35NoYes056
110S:S:D291 S:S:I295 19.9952.8YesNo045
111S:S:D291 S:S:I256 10.43867YesNo045
112S:S:L296 S:S:W310 13.91123.42YesYes156
113S:S:I285 S:S:W310 10.43862.35NoYes056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPC
Class C
SubFamily Aminoacid
Type Metabotropic glutamate
SubType mGlu7; mGlu7
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 4
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03641-w
Net Summary
Imin 2.62
Number of Linked Nodes 1446
Number of Links 1581
Number of Hubs 181
Number of Links mediated by Hubs 677
Number of Communities 64
Number of Nodes involved in Communities 288
Number of Links involved in Communities 347
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 2715843
Length Of Smallest Path 3
Average Path Length 46.7439
Length of Longest Path 82
Minimum Path Strength 1.13
Average Path Strength 5.82964
Maximum Path Strength 22.71
Minimum Path Correlation 0.7
Average Path Correlation 0.998098
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 64.8372
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.1981
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14831
Sequence
>7EPC_Chain_R
HSIRIEGDV TLGGLFPVH AKGPSGVPC GDIKRENGI HRLEAMLYA 
LDQINSDPN LLPNVTLGA RILDTCSRD TYALEQSLT FVQALIQKD 
TSDVRCFVK PEKVVGVIG ASGSSVSIM VANILRLFQ IPQISYAST 
APELSDDRR YDFFSRVVP PDSFQAQAM VDIVKALGW NYVSTLASE 
GSYGEKGVE SFTQISKEA GGLCIAQSV RIPQERKDR TIDFDRIIK 
QLLDTPNSR AVVIFANDE DIKQILAAA KRADQVGHF LWVGSDSWG 
SKINPLHQH EDIAEGAIT IQPKRATVE GFDAYFTSR TLENNRRNV 
WFAEYWEEN FNCKLDRKC TGQERIGKD SNYEQEGKV QFVIDAVYA 
MAHALHHMN KDLCADYRG VCPEMEQAG GKKLLKYIR NVNFNGSAG 
TPVMFNKNG DAPGRYDIF QYQTTNTSN PGYRLIGQW TDELQLNIE 
DMQWGKGVR EIPASVCTL PCKPGQRKK TQKGTPCCW TCEPCDGYQ 
YQFDEMTCQ HCPYDQRPN ENRTGCQDI PIIKLEWHS PWAVIPVFL 
AMLGIIATI FVMATFIRY NDTPIVRAS GRELSYVLL TGIFLCYII 
TFLMIAKPD VAVCSFRRV FLGLGMCIS YAALLTKTY RIYRIFEQS 
PTSQLAITS SLISVQLLG VFIWFIVDP PNIIIDYDE HKTMNPEQA 
RGVLKCDIT DLQIICSLG YSILLMVTC TVYAFKTRG VPENFNEAK 
YIGFTMYTT CIVWLAFIP IFFGTAQSA EKLYIQTTT LTISMNLSA 
SVALGMLYM PKVYIIIF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14831
Sequence
>7EPC_Chain_S
HSIRIEGDV TLGGLFPVH AKGPSGVPC GDIKRENGI HRLEAMLYA 
LDQINSDPN LLPNVTLGA RILDTCSRD TYALEQSLT FVQALIQKD 
TSDVRCFVK PEKVVGVIG ASGSSVSIM VANILRLFQ IPQISYAST 
APELSDDRR YDFFSRVVP PDSFQAQAM VDIVKALGW NYVSTLASE 
GSYGEKGVE SFTQISKEA GGLCIAQSV RIPQERKDR TIDFDRIIK 
QLLDTPNSR AVVIFANDE DIKQILAAA KRADQVGHF LWVGSDSWG 
SKINPLHQH EDIAEGAIT IQPKRATVE GFDAYFTSR TLENNRRNV 
WFAEYWEEN FNCKLDRKC TGQERIGKD SNYEQEGKV QFVIDAVYA 
MAHALHHMN KDLCADYRG VCPEMEQAG GKKLLKYIR NVNFNGSAG 
TPVMFNKNG DAPGRYDIF QYQTTNTSN PGYRLIGQW TDELQLNIE 
DMQWGKGVR EIPASVCTL PCKPGQRKK TQKGTPCCW TCEPCDGYQ 
YQFDEMTCQ HCPYDQRPN ENRTGCQDI PIIKLEWHS PWAVIPVFL 
AMLGIIATI FVMATFIRY NDTPIVRAS GRELSYVLL TGIFLCYII 
TFLMIAKPD VAVCSFRRV FLGLGMCIS YAALLTKTY RIYRIFEQS 
PTSQLAITS SLISVQLLG VFIWFIVDP PNIIIDYDE HKTMNPEQA 
RGVLKCDIT DLQIICSLG YSILLMVTC TVYAFKTRG VPENFNEAK 
YIGFTMYTT CIVWLAFIP IFFGTAQSA EKLYIQTTT LTISMNLSA 
SVALGMLYM PKVYIIIF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EPDCAminoacidMetabotropic glutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7EPCCAminoacidMetabotropic glutamatemGlu7; mGlu7Homo sapiens---42021-06-2310.1038/s41586-021-03641-w




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EPC.zip



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