psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F5	L:L:R1	8.55	Yes	Yes	3	0	0
2	L:L:R1	R:R:Y201	4.12	Yes	Yes	3	0	1
3	L:L:R1	R:R:E204	10.47	Yes	Yes	3	0	2
4	L:L:R1	R:R:D311	22.63	Yes	No	0	0	3
5	L:L:F5	L:L:P2	11.56	Yes	No	3	0	0
6	L:L:P2	R:R:Y201	5.56	No	Yes	3	0	1
7	L:L:P2	R:R:V212	3.53	No	No	3	0	4
8	L:L:P3	R:R:Y215	5.56	No	Yes	0	0	5
9	L:L:P3	R:R:R297	7.21	No	No	0	0	3
10	L:L:G4	R:R:I213	3.53	No	No	0	0	4
11	L:L:F5	R:R:F121	4.29	Yes	No	0	0	4
12	L:L:F5	R:R:Y201	17.54	Yes	Yes	3	0	1
13	L:L:F5	R:R:A210	5.55	Yes	No	0	0	2
14	L:L:F5	R:R:V212	3.93	Yes	No	3	0	4
15	L:L:P7	L:L:S6	5.34	Yes	No	1	0	0
16	L:L:S6	R:R:S318	4.89	No	Yes	1	0	5
17	L:L:F8	L:L:P7	17.34	Yes	Yes	1	0	0
18	L:L:P7	R:R:W113	8.11	Yes	No	0	0	6
19	L:L:P7	R:R:S318	7.13	Yes	Yes	1	0	5
20	L:L:P7	R:R:F319	4.33	Yes	Yes	1	0	5
21	L:L:F8	R:R:L141	13.4	Yes	No	0	0	7
22	L:L:F8	R:R:F286	8.57	Yes	Yes	1	0	6
23	L:L:F8	R:R:S318	5.28	Yes	Yes	1	0	5
24	L:L:F8	R:R:Y322	14.44	Yes	No	0	0	7
25	L:L:R9	R:R:T290	6.47	No	Yes	0	0	5
26	L:L:R9	R:R:D293	15.48	No	No	0	0	4
27	L:L:R9	R:R:T314	11.64	No	No	0	0	5
28	R:R:N57	R:R:W55	12.43	No	No	0	5	4
29	R:R:E204	R:R:W55	3.27	Yes	No	0	2	4
30	R:R:L56	R:R:Q60	6.65	Yes	No	1	3	5
31	R:R:L56	R:R:V312	4.47	Yes	No	0	3	2
32	R:R:L56	R:R:Q315	3.99	Yes	No	1	3	4
33	R:R:I316	R:R:L56	4.28	No	Yes	0	5	3
34	R:R:F121	R:R:N57	6.04	No	No	0	4	5
35	R:R:Q315	R:R:Q60	14.08	No	No	1	4	5
36	R:R:F319	R:R:Q60	8.2	Yes	No	1	5	5
37	R:R:P61	R:R:P62	5.84	No	No	0	8	4
38	R:R:I117	R:R:P61	5.08	No	No	0	5	8
39	R:R:P61	R:R:S118	3.56	No	No	0	8	4
40	R:R:F319	R:R:L64	15.83	Yes	No	0	5	6
41	R:R:A114	R:R:W65	6.48	No	No	0	7	4
42	R:R:C326	R:R:L67	4.76	No	No	0	8	7
43	R:R:F68	R:R:T72	7.78	Yes	No	0	7	6
44	R:R:F68	R:R:L110	3.65	Yes	No	0	7	8
45	R:R:F68	R:R:P111	14.45	Yes	No	0	7	9
46	R:R:A71	R:R:C326	3.61	No	No	0	8	8
47	R:R:A107	R:R:T72	3.36	No	No	0	6	6
48	R:R:E74	R:R:L330	3.98	No	No	0	8	6
49	R:R:A100	R:R:N75	4.69	No	Yes	0	8	9
50	R:R:D103	R:R:N75	6.73	Yes	Yes	7	9	9
51	R:R:L104	R:R:N75	9.61	No	Yes	0	7	9
52	R:R:N75	R:R:P329	4.89	Yes	No	7	9	9
53	R:R:F77	R:R:V81	3.93	No	Yes	2	6	8
54	R:R:F339	R:R:F77	5.36	Yes	No	2	8	6
55	R:R:F77	R:R:S343	7.93	No	No	2	6	6
56	R:R:F82	R:R:V78	3.93	Yes	Yes	2	7	8
57	R:R:A100	R:R:V78	3.39	No	Yes	0	8	8
58	R:R:V333	R:R:V78	8.02	No	Yes	2	7	8
59	R:R:F339	R:R:V78	6.55	Yes	Yes	2	8	8
60	R:R:F339	R:R:V81	9.18	Yes	Yes	2	8	8
61	R:R:S343	R:R:V81	4.85	No	Yes	2	6	8
62	R:R:V346	R:R:V81	4.81	No	Yes	0	5	8
63	R:R:E93	R:R:F82	15.16	No	Yes	0	7	7
64	R:R:F339	R:R:F82	6.43	Yes	Yes	2	8	7
65	R:R:H85	R:R:S87	8.37	Yes	No	8	5	5
66	R:R:H85	R:R:K342	10.48	Yes	Yes	8	5	5
67	R:R:K342	R:R:S87	4.59	Yes	No	8	5	5
68	R:R:E93	R:R:T90	9.88	No	No	0	7	7
69	R:R:V91	R:R:Y95	5.05	Yes	Yes	9	6	7
70	R:R:A174	R:R:V91	3.39	No	Yes	9	7	6
71	R:R:E93	R:R:K342	9.45	No	Yes	0	7	5
72	R:R:I94	R:R:V171	4.61	No	No	0	6	3
73	R:R:L150	R:R:Y95	7.03	No	Yes	0	6	7
74	R:R:D154	R:R:Y95	9.2	No	Yes	0	8	7
75	R:R:A174	R:R:Y95	5.34	No	Yes	9	7	7
76	R:R:L96	R:R:V333	4.47	No	No	0	8	7
77	R:R:F147	R:R:N98	12.08	Yes	No	6	8	9
78	R:R:N98	R:R:S178	10.43	No	No	6	9	7
79	R:R:N98	R:R:W182	5.65	No	Yes	6	9	9
80	R:R:D103	R:R:L99	6.79	Yes	No	0	9	9
81	R:R:L148	R:R:L99	5.54	No	No	0	8	9
82	R:R:D103	R:R:S144	4.42	Yes	No	0	9	9
83	R:R:D103	R:R:S325	7.36	Yes	No	0	9	8
84	R:R:D103	R:R:P329	8.05	Yes	No	7	9	9
85	R:R:I105	R:R:N140	11.33	No	Yes	0	7	8
86	R:R:I137	R:R:L106	4.28	No	No	0	6	7
87	R:R:L106	R:R:N140	4.12	No	Yes	0	7	8
88	R:R:L106	R:R:S325	6.01	No	No	0	7	8
89	R:R:L110	R:R:Y322	8.21	No	No	0	8	7
90	R:R:F112	R:R:F125	15	No	Yes	0	6	7
91	R:R:F112	R:R:V133	13.11	No	No	0	6	5
92	R:R:T116	R:R:W113	3.64	No	No	0	5	6
93	R:R:N134	R:R:W113	9.04	Yes	No	0	5	6
94	R:R:I115	R:R:N119	4.25	No	No	0	4	4
95	R:R:F125	R:R:I115	8.79	Yes	No	0	7	4
96	R:R:T116	R:R:W123	8.49	No	Yes	0	5	8
97	R:R:F319	R:R:I117	3.77	Yes	No	0	5	5
98	R:R:L124	R:R:N119	5.49	No	No	0	1	4
99	R:R:H206	R:R:N120	7.65	No	No	0	2	3
100	R:R:E204	R:R:F121	5.83	Yes	No	0	2	4
101	R:R:D122	R:R:V208	8.76	No	No	0	5	1
102	R:R:D122	R:R:T209	5.78	No	No	0	5	5
103	R:R:F125	R:R:W123	19.04	Yes	Yes	0	7	8
104	R:R:C130	R:R:W123	5.22	No	Yes	5	9	8
105	R:R:N134	R:R:W123	3.39	Yes	Yes	5	5	8
106	R:R:C211	R:R:W123	9.14	Yes	Yes	5	9	8
107	R:R:F125	R:R:L129	6.09	Yes	No	0	7	5
108	R:R:G126	R:R:M198	3.49	No	No	0	8	6
109	R:R:E127	R:R:R131	6.98	No	No	0	3	7
110	R:R:E127	R:R:T197	8.47	No	No	0	3	4
111	R:R:E127	R:R:M198	5.41	No	No	0	3	6
112	R:R:C130	R:R:R196	4.18	No	Yes	5	9	4
113	R:R:C130	R:R:C211	7.28	No	Yes	5	9	9
114	R:R:N134	R:R:R196	24.1	Yes	Yes	5	5	4
115	R:R:C211	R:R:N134	4.72	Yes	Yes	5	9	5
116	R:R:S138	R:R:Y142	6.36	No	Yes	0	5	7
117	R:R:M139	R:R:T185	7.53	No	No	0	6	8
118	R:R:M139	R:R:S189	4.6	No	No	0	6	7
119	R:R:L141	R:R:W283	4.56	No	Yes	0	7	9
120	R:R:W146	R:R:Y142	3.86	Yes	Yes	10	5	7
121	R:R:L188	R:R:Y142	9.38	No	Yes	10	5	7
122	R:R:L228	R:R:Y142	3.52	No	Yes	0	5	7
123	R:R:S143	R:R:W182	8.65	No	Yes	0	7	9
124	R:R:S143	R:R:T185	6.4	No	No	0	7	8
125	R:R:G232	R:R:I145	3.53	No	No	0	6	8
126	R:R:I145	R:R:P236	3.39	No	No	0	8	9
127	R:R:I145	R:R:W283	9.4	No	Yes	0	8	9
128	R:R:M149	R:R:W146	3.49	No	Yes	0	7	5
129	R:R:I181	R:R:W146	8.22	No	Yes	0	7	5
130	R:R:C184	R:R:W146	6.53	No	Yes	0	4	5
131	R:R:T185	R:R:W146	3.64	No	Yes	0	8	5
132	R:R:L188	R:R:W146	3.42	No	Yes	10	5	5
133	R:R:V231	R:R:W146	4.9	No	Yes	0	5	5
134	R:R:F147	R:R:S178	5.28	Yes	No	6	8	7
135	R:R:F147	R:R:I181	7.54	Yes	No	0	8	7
136	R:R:F147	R:R:W182	6.01	Yes	Yes	6	8	9
137	R:R:L148	R:R:N328	6.87	No	No	4	8	9
138	R:R:L148	R:R:Y332	3.52	No	Yes	4	8	9
139	R:R:M149	R:R:P236	5.03	No	No	0	7	9
140	R:R:M149	R:R:V239	7.61	No	No	0	7	6
141	R:R:R155	R:R:V151	7.85	No	No	0	9	9
142	R:R:I240	R:R:S152	9.29	No	No	0	8	9
143	R:R:C243	R:R:S152	5.16	No	No	0	7	9
144	R:R:I153	R:R:V239	4.61	No	No	0	6	6
145	R:R:C243	R:R:I153	3.27	No	No	0	7	6
146	R:R:D154	R:R:R169	16.68	No	No	0	8	6
147	R:R:R155	R:R:Y332	7.2	No	Yes	0	9	9
148	R:R:V160	R:R:Y156	8.83	No	Yes	0	7	8
149	R:R:K161	R:R:Y156	9.55	No	Yes	0	6	8
150	R:R:F242	R:R:Y156	7.22	No	Yes	11	4	8
151	R:R:C243	R:R:Y156	4.03	No	Yes	0	7	8
152	R:R:Q246	R:R:Y156	4.51	No	Yes	11	4	8
153	R:R:L157	R:R:M165	12.72	No	No	0	5	6
154	R:R:I247	R:R:L159	5.71	No	No	0	8	8
155	R:R:V160	R:R:V250	4.81	No	No	0	7	5
156	R:R:K161	R:R:M165	7.2	No	No	0	6	6
157	R:R:M168	R:R:W173	4.65	No	No	0	3	4
158	R:R:K175	R:R:V171	4.55	No	No	0	2	3
159	R:R:R172	R:R:W173	8	No	No	0	4	4
160	R:R:W173	R:R:Y177	8.68	No	No	0	4	5
161	R:R:S178	R:R:W182	3.71	No	Yes	6	7	9
162	R:R:G183	R:R:L186	5.13	No	No	0	4	4
163	R:R:P191	R:R:S190	3.56	No	No	0	7	4
164	R:R:F195	R:R:V194	10.49	Yes	No	0	4	4
165	R:R:F195	R:R:P216	13	Yes	No	12	4	3
166	R:R:F195	R:R:W220	5.01	Yes	Yes	12	4	2
167	R:R:C211	R:R:R196	6.96	Yes	Yes	5	9	4
168	R:R:I213	R:R:R196	13.78	No	Yes	0	4	4
169	R:R:S214	R:R:T197	9.59	No	No	0	4	4
170	R:R:M198	R:R:T209	12.04	No	No	0	6	5
171	R:R:K199	R:R:V212	7.59	No	No	0	4	4
172	R:R:D203	R:R:Y201	8.05	No	Yes	0	2	1
173	R:R:E204	R:R:Y201	6.73	Yes	Yes	3	2	1
174	R:R:I213	R:R:Y215	18.13	No	Yes	0	4	5
175	R:R:W220	R:R:Y215	3.86	Yes	Yes	0	2	5
176	R:R:E221	R:R:Y215	6.73	No	Yes	0	4	5
177	R:R:T224	R:R:Y215	6.24	No	Yes	0	5	5
178	R:R:P216	R:R:W220	5.4	No	Yes	12	3	2
179	R:R:I219	R:R:S217	4.64	No	No	0	1	3
180	R:R:E221	R:R:L218	5.3	No	No	0	4	2
181	R:R:I219	R:R:W220	5.87	No	Yes	0	1	2
182	R:R:E221	R:R:R297	11.63	No	No	0	4	3
183	R:R:N225	R:R:T290	4.39	No	Yes	0	5	5
184	R:R:D293	R:R:N225	4.04	No	No	0	4	5
185	R:R:N225	R:R:T294	7.31	No	No	0	5	5
186	R:R:M226	R:R:T294	6.02	No	No	0	4	5
187	R:R:N229	R:R:Q287	6.6	No	No	0	5	8
188	R:R:N229	R:R:T290	10.24	No	Yes	0	5	5
189	R:R:F233	R:R:L234	3.65	Yes	No	0	8	5
190	R:R:F233	R:R:L237	8.53	Yes	Yes	0	8	6
191	R:R:F233	R:R:L284	4.87	Yes	No	0	8	5
192	R:R:F233	R:R:Q287	15.23	Yes	No	0	8	8
193	R:R:L235	R:R:P236	3.28	No	No	0	6	9
194	R:R:F279	R:R:L237	3.65	No	Yes	0	9	6
195	R:R:M245	R:R:T241	4.52	No	No	0	3	4
196	R:R:F242	R:R:Q246	8.2	No	No	11	4	4
197	R:R:M248	R:R:T244	4.52	No	No	0	4	8
198	R:R:L276	R:R:T244	5.9	No	No	0	7	8
199	R:R:Q246	R:R:Q249	5.12	No	No	0	4	4
200	R:R:M248	R:R:T269	6.02	No	No	0	4	6
201	R:R:L273	R:R:M248	5.65	No	No	0	5	4
202	R:R:E265	R:R:L251	3.98	No	Yes	0	7	8
203	R:R:L251	R:R:T269	5.9	Yes	No	0	8	6
204	R:R:N253	R:R:N254	5.45	No	No	0	4	5
205	R:R:E255	R:R:Q263	14.02	No	No	13	4	4
206	R:R:E255	R:R:E265	10.15	No	No	13	4	7
207	R:R:E255	R:R:R266	9.3	No	No	0	4	4
208	R:R:E265	R:R:Q263	5.1	No	No	13	7	4
209	R:R:L271	R:R:R267	6.07	No	No	0	8	7
210	R:R:L271	R:R:V335	4.47	No	No	0	8	6
211	R:R:V275	R:R:V331	4.81	No	No	4	8	7
212	R:R:V275	R:R:Y332	12.62	No	Yes	4	8	9
213	R:R:I280	R:R:L276	4.28	No	No	0	6	7
214	R:R:L278	R:R:L327	11.07	No	No	0	6	7
215	R:R:F279	R:R:W283	10.02	No	Yes	0	9	9
216	R:R:C282	R:R:N324	9.45	No	No	0	8	9
217	R:R:A321	R:R:W283	3.89	No	Yes	0	8	9
218	R:R:N324	R:R:W283	11.3	No	Yes	0	9	9
219	R:R:L284	R:R:P285	3.28	No	No	0	5	9
220	R:R:A317	R:R:P285	3.74	No	No	0	7	9
221	R:R:F286	R:R:Q287	3.51	Yes	No	0	6	8
222	R:R:F286	R:R:T290	3.89	Yes	Yes	0	6	5
223	R:R:F286	R:R:S318	5.28	Yes	Yes	1	6	5
224	R:R:I313	R:R:S289	4.64	No	No	0	5	5
225	R:R:S289	R:R:T314	6.4	No	No	0	5	5
226	R:R:F291	R:R:L295	8.53	No	No	0	5	4
227	R:R:I310	R:R:L292	9.99	No	No	0	5	5
228	R:R:D293	R:R:R297	11.91	No	No	0	4	3
229	R:R:I300	R:R:L295	7.14	No	No	0	1	4
230	R:R:E307	R:R:H296	14.77	No	No	0	3	3
231	R:R:D306	R:R:L301	12.21	No	No	0	1	1
232	R:R:D306	R:R:S303	5.89	No	No	0	1	4
233	R:R:I309	R:R:Q305	5.49	No	No	0	3	3
234	R:R:D311	R:R:E307	3.9	No	No	0	3	3
235	R:R:R308	R:R:V312	5.23	No	No	0	1	2
236	R:R:F319	R:R:Q315	5.86	Yes	No	1	5	4
237	R:R:F319	R:R:Y322	11.35	Yes	No	0	5	7
238	R:R:N324	R:R:N328	13.62	No	No	0	9	9
239	R:R:N328	R:R:Y332	6.98	No	Yes	4	9	9
240	R:R:I334	R:R:L330	5.71	No	No	0	6	6
241	R:R:V331	R:R:Y332	3.79	No	Yes	4	7	9
242	R:R:F339	R:R:V333	9.18	Yes	No	2	8	7
243	R:R:K337	R:R:R340	4.95	No	No	0	4	8
244	R:R:F339	R:R:S343	7.93	Yes	No	2	8	6
245	R:R:V171	R:R:V91	3.21	No	Yes	0	3	6
246	R:R:C83	R:R:L79	3.17	No	No	0	3	7
247	R:R:T294	R:R:V222	3.17	No	No	0	5	3
248	R:R:T244	R:R:V272	3.17	No	No	0	8	7
249	R:R:C282	R:R:L278	3.17	No	No	0	8	6
250	R:R:A114	R:R:L64	3.15	No	No	0	7	6
251	R:R:A135	R:R:L193	3.15	No	No	0	6	5
252	R:R:A158	R:R:L159	3.15	No	No	0	8	8
253	R:R:A268	R:R:L251	3.15	No	Yes	0	8	8
254	R:R:A102	R:R:N140	3.13	No	Yes	0	8	8
255	R:R:M192	R:R:S138	3.07	No	No	0	4	5
256	R:R:I76	R:R:T72	3.04	No	No	0	3	6
257	R:R:F82	R:R:G97	3.01	Yes	No	0	7	6
258	R:R:F112	R:R:G109	3.01	No	No	0	6	6
259	R:R:R308	R:R:W55	3	No	No	0	1	4
260	R:R:L67	R:R:S323	3	No	No	0	7	4
261	R:R:L70	R:R:V66	2.98	No	No	0	5	5
262	R:R:L73	R:R:V69	2.98	No	No	0	4	4
263	R:R:L298	R:R:V222	2.98	No	No	0	1	3
264	R:R:L227	R:R:V231	2.98	No	No	0	4	5
265	R:R:L330	R:R:V331	2.98	No	No	0	6	7
266	R:R:L237	R:R:T241	2.95	Yes	No	0	6	4
267	R:R:I309	R:R:I313	2.94	No	No	0	3	5
268	R:R:I316	R:R:M320	2.92	No	No	0	5	7
269	R:R:F195	R:R:P191	2.89	Yes	No	0	4	7
270	R:R:I59	R:R:L56	2.85	No	Yes	0	5	3
271	R:R:I280	R:R:L237	2.85	No	Yes	0	6	6
272	R:R:I247	R:R:L251	2.85	No	Yes	0	8	8
273	R:R:I280	R:R:L284	2.85	No	No	0	6	5
274	R:R:I136	R:R:N140	2.83	No	Yes	0	5	8
275	R:R:L186	R:R:M139	2.83	No	No	0	4	6
276	R:R:G126	R:R:W123	2.81	No	Yes	0	8	8
277	R:R:H296	R:R:S302	2.79	No	No	0	3	1
278	R:R:N120	R:R:N57	2.72	No	No	0	3	5
279	R:R:F223	R:R:T224	2.59	No	No	0	3	5
280	R:R:V151	R:R:Y95	2.52	No	Yes	0	9	7
281	R:R:F291	R:R:N229	2.42	No	No	0	5	5
282	R:R:L176	R:R:Y177	2.34	No	No	0	3	5
283	R:R:G299	R:R:S302	1.86	No	No	0	1	1
284	R:R:G170	R:R:V91	1.84	No	Yes	0	6	6
285	R:R:G336	R:R:V335	1.84	No	No	0	8	6
286	R:R:A107	R:R:A71	1.79	No	No	0	6	8
287	R:R:G166	R:R:M165	1.75	No	No	0	4	6
288	R:R:C304	R:R:S303	1.72	No	No	0	8	4
289	R:R:G97	R:R:L79	1.71	No	No	0	6	7
290	R:R:A135	R:R:S189	1.71	No	No	0	6	7
291	R:R:C89	R:R:I94	1.64	No	No	0	5	6
292	R:R:S80	R:R:V81	1.62	No	Yes	0	4	8
293	R:R:V270	R:R:V274	1.6	No	No	0	6	5
294	R:R:C326	R:R:L70	1.59	No	No	0	8	5
295	R:R:C83	R:R:L84	1.59	No	No	0	3	4
296	R:R:C108	R:R:L104	1.59	No	No	0	5	7
297	R:R:G205	R:R:H206	1.59	No	No	0	3	2
298	R:R:I136	R:R:V132	1.54	No	No	0	5	4
299	R:R:K161	R:R:S164	1.53	No	No	0	6	4
300	R:R:I59	R:R:T58	1.52	No	No	0	5	6
301	R:R:I310	R:R:T314	1.52	No	No	0	5	5
302	R:R:N207	R:R:S202	1.49	No	No	0	6	2
303	R:R:L234	R:R:V230	1.49	No	No	0	5	5
304	R:R:N254	R:R:V250	1.48	No	No	0	5	5
305	R:R:L129	R:R:T128	1.47	No	No	0	5	2
306	R:R:F63	R:R:P62	1.44	No	No	0	4	4
307	R:R:Q305	R:R:S303	1.44	No	No	0	3	4
308	R:R:N253	R:R:Q257	1.32	No	No	0	4	3
309	R:R:F68	R:R:V69	1.31	Yes	No	0	7	4
310	R:R:H85	R:R:K86	1.31	Yes	No	0	5	5
311	R:R:K342	R:R:R338	1.24	Yes	No	0	5	5
312	R:R:E345	R:R:H85	1.23	No	Yes	0	5	5
313	R:R:L150	R:R:Y177	1.17	No	No	0	6	5
314	R:R:L179	R:R:W182	1.14	No	Yes	0	4	9
315	R:R:E345	R:R:W344	1.09	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R1	11.4425	4	3	0
2	L:L:F5	8.57	6	3	0
3	L:L:P7	8.45	5	1	0
4	L:L:F8	11.806	5	1	0
5	R:R:L56	4.448	5	1	3
6	R:R:F68	6.7975	4	0	7
7	R:R:N75	6.48	4	7	9
8	R:R:V78	5.4725	4	2	8
9	R:R:V81	4.878	5	2	8
10	R:R:F82	7.1325	4	2	7
11	R:R:H85	5.3475	4	8	5
12	R:R:V91	3.3725	4	9	6
13	R:R:Y95	5.828	5	9	7
14	R:R:D103	6.67	5	7	9
15	R:R:W123	8.015	6	5	8
16	R:R:F125	12.23	4	0	7
17	R:R:N134	10.3125	4	5	5
18	R:R:N140	5.3525	4	0	8
19	R:R:Y142	5.78	4	10	7
20	R:R:W146	4.86571	7	10	5
21	R:R:F147	7.7275	4	6	8
22	R:R:Y156	6.828	5	11	8
23	R:R:W182	5.032	5	6	9
24	R:R:F195	7.8475	4	12	4
25	R:R:R196	12.255	4	5	4
26	R:R:Y201	8.4	5	3	1
27	R:R:E204	6.575	4	3	2
28	R:R:C211	7.025	4	5	9
29	R:R:Y215	8.104	5	0	5
30	R:R:W220	5.035	4	12	2
31	R:R:F233	8.07	4	0	8
32	R:R:L237	4.495	4	0	6
33	R:R:L251	3.97	4	0	8
34	R:R:W283	7.834	5	0	9
35	R:R:F286	5.3125	4	1	6
36	R:R:T290	6.2475	4	0	5
37	R:R:S318	5.645	4	1	5
38	R:R:F319	8.22333	6	1	5
39	R:R:Y332	6.822	5	4	9
40	R:R:F339	7.43833	6	2	8
41	R:R:K342	6.44	4	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F5	R:R:F121	21.9599	4.29	Yes	No	0	0	4
2	R:R:E204	R:R:F121	13.7375	5.83	Yes	No	0	2	4
3	L:L:F5	R:R:Y201	10.9503	17.54	Yes	Yes	3	0	1
4	R:R:E204	R:R:Y201	24.5442	6.73	Yes	Yes	3	2	1
5	L:L:F5	L:L:R1	10.8204	8.55	Yes	Yes	3	0	0
6	L:L:R1	R:R:E204	27.1673	10.47	Yes	Yes	3	0	2
7	R:R:E204	R:R:W55	67.7256	3.27	Yes	No	0	2	4
8	R:R:R308	R:R:W55	94.8268	3	No	No	0	1	4
9	R:R:R308	R:R:V312	97.4749	5.23	No	No	0	1	2
10	R:R:L56	R:R:V312	100	4.47	Yes	No	0	3	2
11	R:R:L56	R:R:Q60	56.5109	6.65	Yes	No	1	3	5
12	R:R:F319	R:R:Q60	57.6664	8.2	Yes	No	1	5	5
13	L:L:P7	R:R:F319	78.1039	4.33	Yes	Yes	1	0	5
14	L:L:P7	R:R:W113	51.5132	8.11	Yes	No	0	0	6
15	R:R:N134	R:R:W113	31.3218	9.04	Yes	No	0	5	6
16	R:R:N134	R:R:R196	11.2283	24.1	Yes	Yes	5	5	4
17	R:R:I213	R:R:R196	11.7252	13.78	No	Yes	0	4	4
18	R:R:I213	R:R:Y215	10.1299	18.13	No	Yes	0	4	5
19	R:R:F121	R:R:N57	13.8355	6.04	No	No	0	4	5
20	R:R:N57	R:R:W55	24.6103	12.43	No	No	0	5	4
21	R:R:L56	R:R:Q315	56.4882	3.99	Yes	No	1	3	4
22	R:R:F319	R:R:Q315	57.6367	5.86	Yes	No	1	5	4
23	L:L:F8	L:L:P7	75.1664	17.34	Yes	Yes	1	0	0
24	L:L:F8	R:R:F286	52.2949	8.57	Yes	Yes	1	0	6
25	R:R:F286	R:R:T290	38.5027	3.89	Yes	Yes	0	6	5
26	L:L:R9	R:R:T290	24.9635	6.47	No	Yes	0	0	5
27	R:R:D293	R:R:R297	16.2101	11.91	No	No	0	4	3
28	R:R:F319	R:R:Y322	51.4927	11.35	Yes	No	0	5	7
29	L:L:F8	R:R:Y322	55.8546	14.44	Yes	No	0	0	7
30	L:L:P7	R:R:S318	23.5529	7.13	Yes	Yes	1	0	5
31	R:R:F286	R:R:S318	23.5392	5.28	Yes	Yes	1	6	5
32	R:R:N225	R:R:T290	15.4763	4.39	No	Yes	0	5	5
33	L:L:F8	R:R:L141	95.8204	13.4	Yes	No	0	0	7
34	L:L:R9	R:R:T314	16.299	11.64	No	No	0	0	5
35	R:R:L110	R:R:Y322	14.0542	8.21	No	No	0	8	7
36	R:R:F68	R:R:L110	13.1518	3.65	Yes	No	0	7	8
37	R:R:L141	R:R:W283	95.4444	4.56	No	Yes	0	7	9
38	R:R:N324	R:R:W283	61.242	11.3	No	Yes	0	9	9
39	R:R:N324	R:R:N328	58.2429	13.62	No	No	0	9	9
40	R:R:N328	R:R:Y332	21.3423	6.98	No	Yes	4	9	9
41	R:R:L148	R:R:N328	36.1372	6.87	No	No	4	8	9
42	R:R:L148	R:R:L99	37.4294	5.54	No	No	0	8	9
43	R:R:D103	R:R:L99	36.5497	6.79	Yes	No	0	9	9
44	R:R:D103	R:R:N75	26.5109	6.73	Yes	Yes	7	9	9
45	R:R:A100	R:R:N75	23.7557	4.69	No	Yes	0	8	9
46	R:R:A100	R:R:V78	22.7985	3.39	No	Yes	0	8	8
47	R:R:F82	R:R:V78	14.0406	3.93	Yes	Yes	2	7	8
48	R:R:R155	R:R:Y332	17.8145	7.2	No	Yes	0	9	9
49	R:R:R155	R:R:V151	16.9234	7.85	No	No	0	9	9
50	R:R:V151	R:R:Y95	16.0187	2.52	No	Yes	0	9	7
51	R:R:I145	R:R:W283	46.0369	9.4	No	Yes	0	8	9
52	R:R:I145	R:R:P236	44.3642	3.39	No	No	0	8	9
53	R:R:M149	R:R:P236	42.6732	5.03	No	No	0	7	9
54	R:R:M149	R:R:W146	24.8428	3.49	No	Yes	0	7	5
55	R:R:T185	R:R:W146	10.2188	3.64	No	Yes	0	8	5
56	R:R:T116	R:R:W113	19.5488	3.64	No	No	0	5	6
57	R:R:T116	R:R:W123	18.742	8.49	No	Yes	0	5	8
58	R:R:F125	R:R:W123	18.3546	19.04	Yes	Yes	0	7	8
59	R:R:N134	R:R:W123	19.485	3.39	Yes	Yes	5	5	8
60	R:R:G126	R:R:W123	18.3546	2.81	No	Yes	0	8	8
61	R:R:G126	R:R:M198	16.3332	3.49	No	No	0	8	6
62	R:R:M149	R:R:V239	19.1272	7.61	No	No	0	7	6
63	R:R:I153	R:R:V239	18.1563	4.61	No	No	0	6	6
64	R:R:C243	R:R:I153	17.1809	3.27	No	No	0	7	6
65	R:R:C243	R:R:Y156	14.2274	4.03	No	Yes	0	7	8
66	R:R:F279	R:R:W283	20.9731	10.02	No	Yes	0	9	9
67	R:R:F279	R:R:L237	20.2211	3.65	No	Yes	0	9	6
68	R:R:I280	R:R:L237	34.624	2.85	No	Yes	0	6	6
69	R:R:I280	R:R:L276	50.5378	4.28	No	No	0	6	7
70	R:R:L276	R:R:T244	47.1536	5.9	No	No	0	7	8
71	R:R:M248	R:R:T244	40.7042	4.52	No	No	0	4	8
72	R:R:M248	R:R:T269	33.9129	6.02	No	No	0	4	6
73	R:R:L251	R:R:T269	30.5105	5.9	Yes	No	0	8	6
74	R:R:F286	R:R:Q287	50.2347	3.51	Yes	No	0	6	8
75	R:R:F233	R:R:Q287	52.7119	15.23	Yes	No	0	8	8
76	R:R:F233	R:R:L237	27.0305	8.53	Yes	Yes	0	8	6
77	R:R:F233	R:R:L284	24.6946	4.87	Yes	No	0	8	5
78	R:R:I280	R:R:L284	20.9959	2.85	No	No	0	6	5
79	R:R:W220	R:R:Y215	13.1791	3.86	Yes	Yes	0	2	5
80	L:L:F5	R:R:V212	21.8847	3.93	Yes	No	3	0	4
81	R:R:K199	R:R:V212	13.6782	7.59	No	No	0	4	4
82	R:R:N229	R:R:Q287	13.1381	6.6	No	No	0	5	8
83	R:R:N229	R:R:T290	12.3815	10.24	No	Yes	0	5	5
84	R:R:E265	R:R:L251	13.7443	3.98	No	Yes	0	7	8
85	R:R:S289	R:R:T314	11.9211	6.4	No	No	0	5	5
86	R:R:I313	R:R:S289	10.4467	4.64	No	No	0	5	5
87	L:L:R1	R:R:D311	13.8902	22.63	Yes	No	0	0	3
88	R:R:D311	R:R:E307	11.1281	3.9	No	No	0	3	3
89	L:L:F5	R:R:A210	10.9458	5.55	Yes	No	0	0	2

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:Y201	4.12	3	Yes	Yes	0	1	0	1
L:L:R1	R:R:E204	10.47	3	Yes	Yes	0	2	0	1
L:L:R1	R:R:D311	22.63	3	Yes	No	0	3	0	1
L:L:P2	R:R:Y201	5.56	3	No	Yes	0	1	0	1
L:L:P2	R:R:V212	3.53	3	No	No	0	4	0	1
L:L:P3	R:R:Y215	5.56	0	No	Yes	0	5	0	1
L:L:P3	R:R:R297	7.21	0	No	No	0	3	0	1
L:L:G4	R:R:I213	3.53	0	No	No	0	4	0	1
L:L:F5	R:R:F121	4.29	3	Yes	No	0	4	0	1
L:L:F5	R:R:Y201	17.54	3	Yes	Yes	0	1	0	1
L:L:F5	R:R:A210	5.55	3	Yes	No	0	2	0	1
L:L:F5	R:R:V212	3.93	3	Yes	No	0	4	0	1
L:L:S6	R:R:S318	4.89	1	No	Yes	0	5	0	1
L:L:P7	R:R:W113	8.11	1	Yes	No	0	6	0	1
L:L:P7	R:R:S318	7.13	1	Yes	Yes	0	5	0	1
L:L:P7	R:R:F319	4.33	1	Yes	Yes	0	5	0	1
L:L:F8	R:R:L141	13.4	1	Yes	No	0	7	0	1
L:L:F8	R:R:F286	8.57	1	Yes	Yes	0	6	0	1
L:L:F8	R:R:S318	5.28	1	Yes	Yes	0	5	0	1
L:L:F8	R:R:Y322	14.44	1	Yes	No	0	7	0	1
L:L:R9	R:R:T290	6.47	0	No	Yes	0	5	0	1
L:L:R9	R:R:D293	15.48	0	No	No	0	4	0	1
L:L:R9	R:R:T314	11.64	0	No	No	0	5	0	1
R:R:N57	R:R:W55	12.43	0	No	No	5	4	2	2
R:R:E204	R:R:W55	3.27	3	Yes	No	2	4	1	2
R:R:F121	R:R:N57	6.04	0	No	No	4	5	1	2
R:R:Q315	R:R:Q60	14.08	1	No	No	4	5	2	2
R:R:F319	R:R:Q60	8.2	1	Yes	No	5	5	1	2
R:R:F319	R:R:L64	15.83	1	Yes	No	5	6	1	2
R:R:L110	R:R:Y322	8.21	0	No	No	8	7	2	1
R:R:T116	R:R:W113	3.64	0	No	No	5	6	2	1
R:R:N134	R:R:W113	9.04	5	Yes	No	5	6	2	1
R:R:F319	R:R:I117	3.77	1	Yes	No	5	5	1	2
R:R:E204	R:R:F121	5.83	3	Yes	No	2	4	1	1
R:R:N134	R:R:R196	24.1	5	Yes	Yes	5	4	2	2
R:R:L141	R:R:W283	4.56	0	No	Yes	7	9	1	2
R:R:I213	R:R:R196	13.78	0	No	Yes	4	4	1	2
R:R:K199	R:R:V212	7.59	0	No	No	4	4	2	1
R:R:D203	R:R:Y201	8.05	0	No	Yes	2	1	2	1
R:R:E204	R:R:Y201	6.73	3	Yes	Yes	2	1	1	1
R:R:I213	R:R:Y215	18.13	0	No	Yes	4	5	1	1
R:R:W220	R:R:Y215	3.86	12	Yes	Yes	2	5	2	1
R:R:E221	R:R:Y215	6.73	0	No	Yes	4	5	2	1
R:R:T224	R:R:Y215	6.24	0	No	Yes	5	5	2	1
R:R:E221	R:R:R297	11.63	0	No	No	4	3	2	1
R:R:N225	R:R:T290	4.39	0	No	Yes	5	5	2	1
R:R:D293	R:R:N225	4.04	0	No	No	4	5	1	2
R:R:N229	R:R:Q287	6.6	0	No	No	5	8	2	2
R:R:N229	R:R:T290	10.24	0	No	Yes	5	5	2	1
R:R:F286	R:R:Q287	3.51	1	Yes	No	6	8	1	2
R:R:F286	R:R:T290	3.89	1	Yes	Yes	6	5	1	1
R:R:F286	R:R:S318	5.28	1	Yes	Yes	6	5	1	1
R:R:S289	R:R:T314	6.4	0	No	No	5	5	2	1
R:R:D293	R:R:R297	11.91	0	No	No	4	3	1	1
R:R:D311	R:R:E307	3.9	0	No	No	3	3	1	2
R:R:F319	R:R:Q315	5.86	1	Yes	No	5	4	1	2
R:R:F319	R:R:Y322	11.35	1	Yes	No	5	7	1	1
R:R:I310	R:R:T314	1.52	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F2O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.27
Number of Linked Nodes	279
Number of Links	315
Number of Hubs	41
Number of Links mediated by Hubs	157
Number of Communities	13
Number of Nodes involved in Communities	57
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	103021
Length Of Smallest Path	3
Average Path Length	15.9545
Length of Longest Path	31
Minimum Path Strength	1.16
Average Path Strength	7.0686
Maximum Path Strength	18.94
Minimum Path Correlation	0.7
Average Path Correlation	0.922066
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	38.8772
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9055
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30411
Sequence	>7F2O_nogp_Chain_R W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H K S S C T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N F D W L F G E T L C R V V N A I I S M N L Y S S I W F L M L V S I D R Y L A L V K T M S M G R M R G V R W A K L Y S L V I W G C T L L L S S P M L V F R T M K E Y S D E G H N V T A C V I S Y P S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G I L S S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R F R K K S W E V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F6H	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-	Gq/β1/γ2	2.9	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6H (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-		2.9	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6I	A	Peptide	Bradykinin	BK₂	Homo sapiens	Kallidin	-	Gq/β1/γ2	2.8	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6I (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Kallidin	-		2.8	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F2O	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-10-13	doi.org/10.1038/s41594-021-00645-y
	7F2O (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-		2.9	2021-10-13	doi.org/10.1038/s41594-021-00645-y

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