psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C304	R:R:C47	7.28	No	No	0	8	7
2	R:R:G205	R:R:Q49	4.93	No	No	0	3	2
3	R:R:L53	R:R:V50	7.45	No	No	0	3	4
4	R:R:R308	R:R:V50	5.23	No	No	0	1	4
5	R:R:W52	R:R:W55	3.75	No	No	0	3	4
6	L:L:R2	R:R:L53	10.93	Yes	No	0	0	3
7	R:R:L56	R:R:W55	3.42	Yes	No	0	3	4
8	R:R:I59	R:R:W55	11.74	No	No	0	5	4
9	R:R:L56	R:R:Q60	3.99	Yes	No	1	3	5
10	R:R:L56	R:R:Q315	6.65	Yes	Yes	1	3	4
11	R:R:N120	R:R:N57	9.54	No	Yes	1	3	5
12	R:R:F121	R:R:N57	6.04	Yes	Yes	1	4	5
13	R:R:E204	R:R:N57	6.57	Yes	Yes	1	2	5
14	R:R:N57	R:R:Q315	5.28	Yes	Yes	1	5	4
15	R:R:Q315	R:R:Q60	6.4	Yes	No	1	4	5
16	R:R:F319	R:R:Q60	7.03	Yes	No	1	5	5
17	R:R:P61	R:R:P62	5.84	No	No	0	8	4
18	R:R:I117	R:R:P61	3.39	No	No	0	5	8
19	R:R:P61	R:R:S118	3.56	No	No	0	8	4
20	R:R:A114	R:R:L64	3.15	No	No	0	7	6
21	R:R:F319	R:R:L64	13.4	Yes	No	0	5	6
22	R:R:A114	R:R:W65	3.89	No	No	0	7	4
23	R:R:L110	R:R:L67	4.15	No	No	0	8	7
24	R:R:F68	R:R:T72	5.19	No	No	0	7	6
25	R:R:F68	R:R:P111	10.11	No	No	0	7	9
26	R:R:C326	R:R:L70	4.76	No	No	0	8	5
27	R:R:E74	R:R:P329	7.86	No	No	0	8	9
28	R:R:E74	R:R:L330	3.98	No	No	0	8	6
29	R:R:D103	R:R:N75	9.42	Yes	No	0	9	9
30	R:R:N75	R:R:P329	9.77	No	No	0	9	9
31	R:R:I76	R:R:L104	4.28	No	No	0	3	7
32	R:R:F77	R:R:V81	5.24	No	Yes	0	6	8
33	R:R:F82	R:R:V78	3.93	Yes	No	2	7	8
34	R:R:V333	R:R:V78	4.81	Yes	No	2	7	8
35	R:R:A100	R:R:L79	3.15	No	No	0	8	7
36	R:R:F339	R:R:V81	7.87	No	Yes	0	8	8
37	R:R:S343	R:R:V81	3.23	No	Yes	0	6	8
38	R:R:F82	R:R:L96	3.65	Yes	No	2	7	8
39	R:R:F82	R:R:V333	3.93	Yes	Yes	2	7	7
40	R:R:F339	R:R:F82	6.43	No	Yes	2	8	7
41	R:R:L84	R:R:V346	4.47	No	No	0	4	5
42	R:R:H85	R:R:S87	8.37	Yes	No	0	5	5
43	R:R:H85	R:R:K342	18.34	Yes	No	0	5	5
44	R:R:E345	R:R:H85	8.62	No	Yes	0	5	5
45	R:R:C89	R:R:E93	6.08	No	No	0	5	7
46	R:R:E93	R:R:T90	5.64	No	No	0	7	7
47	R:R:V91	R:R:Y95	5.05	Yes	Yes	5	6	7
48	R:R:D154	R:R:V91	5.84	Yes	Yes	5	8	6
49	R:R:R169	R:R:V91	11.77	Yes	Yes	5	6	6
50	R:R:E93	R:R:K342	8.1	No	No	0	7	5
51	R:R:I94	R:R:V171	4.61	Yes	No	0	6	3
52	R:R:A174	R:R:I94	3.25	No	Yes	0	7	6
53	R:R:I94	R:R:K175	4.36	Yes	No	0	6	2
54	R:R:L150	R:R:Y95	9.38	No	Yes	0	6	7
55	R:R:D154	R:R:Y95	12.64	Yes	Yes	5	8	7
56	R:R:A174	R:R:Y95	4	No	Yes	0	7	7
57	R:R:L96	R:R:Y332	3.52	No	Yes	2	8	9
58	R:R:L96	R:R:V333	5.96	No	Yes	2	8	7
59	R:R:F147	R:R:N98	15.71	Yes	No	6	8	9
60	R:R:N98	R:R:S178	10.43	No	No	6	9	7
61	R:R:N98	R:R:W182	6.78	No	Yes	6	9	9
62	R:R:L148	R:R:L99	4.15	No	No	0	8	9
63	R:R:D103	R:R:S144	4.42	Yes	No	0	9	9
64	R:R:D103	R:R:S325	4.42	Yes	No	0	9	8
65	R:R:D103	R:R:N328	8.08	Yes	Yes	0	9	9
66	R:R:I105	R:R:N140	11.33	No	No	0	7	8
67	R:R:L106	R:R:N140	4.12	No	No	0	7	8
68	R:R:G109	R:R:I137	3.53	No	No	0	6	6
69	R:R:L110	R:R:Y322	7.03	No	Yes	0	8	7
70	R:R:F112	R:R:F125	11.79	No	Yes	0	6	7
71	R:R:F112	R:R:V133	11.8	No	No	0	6	5
72	R:R:T116	R:R:W113	4.85	No	No	0	5	6
73	R:R:N134	R:R:W113	5.65	No	No	0	5	6
74	L:L:P8	R:R:W113	20.27	Yes	No	0	0	6
75	R:R:F125	R:R:I115	5.02	Yes	No	0	7	4
76	R:R:T116	R:R:W123	4.85	No	Yes	0	5	8
77	R:R:F319	R:R:I117	6.28	Yes	No	0	5	5
78	R:R:L124	R:R:N119	4.12	No	No	0	1	4
79	R:R:E204	R:R:N120	3.94	Yes	No	1	2	3
80	R:R:H206	R:R:N120	10.2	No	No	1	2	3
81	R:R:F121	R:R:Q315	4.68	Yes	Yes	1	4	4
82	L:L:R2	R:R:F121	7.48	Yes	Yes	1	0	4
83	L:L:F6	R:R:F121	13.93	Yes	Yes	1	0	4
84	R:R:D122	R:R:V208	5.84	No	No	0	5	1
85	R:R:F125	R:R:W123	16.04	Yes	Yes	0	7	8
86	R:R:C130	R:R:W123	6.53	No	Yes	7	9	8
87	R:R:M198	R:R:W123	4.65	Yes	Yes	7	6	8
88	R:R:C211	R:R:W123	15.67	No	Yes	7	9	8
89	R:R:F125	R:R:L129	6.09	Yes	No	0	7	5
90	R:R:E127	R:R:R131	12.79	No	No	0	3	7
91	R:R:C130	R:R:M198	3.24	No	Yes	7	9	6
92	R:R:C130	R:R:C211	5.46	No	No	7	9	9
93	R:R:N134	R:R:R196	19.28	No	No	0	5	4
94	R:R:C211	R:R:N134	3.15	No	No	0	9	5
95	R:R:A135	R:R:L193	4.73	No	No	0	6	5
96	R:R:I136	R:R:N140	4.25	No	No	0	5	8
97	R:R:I137	R:R:Y322	3.63	No	Yes	0	6	7
98	R:R:S138	R:R:S189	6.52	No	No	0	5	7
99	R:R:M192	R:R:S138	4.6	No	No	0	4	5
100	R:R:M139	R:R:T185	6.02	No	No	0	6	8
101	R:R:L186	R:R:M139	8.48	No	No	0	4	6
102	R:R:L141	R:R:Y142	7.03	No	Yes	0	7	7
103	R:R:L141	R:R:W283	4.56	No	Yes	0	7	9
104	L:L:F9	R:R:L141	9.74	No	No	0	0	7
105	R:R:L188	R:R:Y142	3.52	No	Yes	0	5	7
106	R:R:L228	R:R:Y142	3.52	No	Yes	0	5	7
107	R:R:S143	R:R:W182	8.65	No	Yes	0	7	9
108	R:R:S143	R:R:T185	9.59	No	No	0	7	8
109	R:R:I145	R:R:P236	3.39	No	No	0	8	9
110	R:R:I145	R:R:W283	7.05	No	Yes	0	8	9
111	R:R:C146	R:R:I181	3.27	No	No	0	5	7
112	R:R:F147	R:R:S178	3.96	Yes	No	6	8	7
113	R:R:F147	R:R:I181	10.05	Yes	No	0	8	7
114	R:R:F147	R:R:W182	10.02	Yes	Yes	6	8	9
115	R:R:L148	R:R:N328	8.24	No	Yes	2	8	9
116	R:R:L148	R:R:Y332	4.69	No	Yes	2	8	9
117	R:R:M149	R:R:V239	9.13	No	Yes	0	7	6
118	R:R:V151	R:R:Y332	3.79	No	Yes	0	9	9
119	R:R:I240	R:R:S152	9.29	No	No	0	8	9
120	R:R:C243	R:R:S152	3.44	No	No	0	7	9
121	R:R:D154	R:R:R169	13.1	Yes	Yes	5	8	6
122	R:R:R155	R:R:Y332	6.17	No	Yes	0	9	9
123	R:R:L157	R:R:Y156	3.52	No	Yes	0	5	8
124	R:R:V160	R:R:Y156	7.57	No	Yes	4	7	8
125	R:R:K161	R:R:Y156	8.36	Yes	Yes	4	6	8
126	R:R:F242	R:R:Y156	4.13	No	Yes	4	4	8
127	R:R:C243	R:R:Y156	5.38	No	Yes	0	7	8
128	R:R:Q246	R:R:Y156	6.76	No	Yes	4	4	8
129	R:R:L157	R:R:M165	4.24	No	No	0	5	6
130	R:R:A158	R:R:R169	6.91	No	Yes	0	8	6
131	R:R:I247	R:R:L159	4.28	No	No	0	8	8
132	R:R:K161	R:R:V160	4.55	Yes	No	4	6	7
133	R:R:V160	R:R:V250	6.41	No	No	0	7	5
134	R:R:K161	R:R:M165	7.2	Yes	No	0	6	6
135	R:R:M163	R:R:T162	6.02	No	No	0	5	7
136	R:R:L176	R:R:W173	5.69	No	No	0	3	4
137	R:R:W173	R:R:Y177	8.68	No	No	0	4	5
138	R:R:P191	R:R:S190	5.34	No	No	0	7	4
139	R:R:F195	R:R:V194	7.87	Yes	No	0	4	4
140	R:R:F195	R:R:Y215	8.25	Yes	Yes	3	4	5
141	R:R:F195	R:R:P216	8.67	Yes	No	3	4	3
142	R:R:F195	R:R:W220	7.02	Yes	Yes	3	4	2
143	R:R:I213	R:R:R196	7.52	Yes	No	3	4	4
144	L:L:G5	R:R:R196	4.5	No	No	3	0	4
145	R:R:S214	R:R:T197	7.99	No	No	0	4	4
146	R:R:K199	R:R:V212	10.62	No	No	1	4	4
147	L:L:P3	R:R:K199	6.69	No	No	1	0	4
148	R:R:D203	R:R:Y201	12.64	No	Yes	0	2	1
149	R:R:E204	R:R:Y201	3.37	Yes	Yes	1	2	1
150	L:L:R2	R:R:Y201	4.12	Yes	Yes	1	0	1
151	L:L:F6	R:R:Y201	11.35	Yes	Yes	1	0	1
152	R:R:E204	R:R:H206	9.85	Yes	No	1	2	2
153	L:L:R2	R:R:E204	3.49	Yes	Yes	1	0	2
154	R:R:G205	R:R:H206	3.18	No	No	0	3	2
155	L:L:P3	R:R:V212	7.07	No	No	1	0	4
156	R:R:I213	R:R:Y215	13.3	Yes	Yes	3	4	5
157	L:L:G5	R:R:I213	3.53	No	Yes	3	0	4
158	R:R:W220	R:R:Y215	8.68	Yes	Yes	3	2	5
159	R:R:E221	R:R:Y215	10.1	No	Yes	0	4	5
160	R:R:T224	R:R:Y215	9.99	No	Yes	0	5	5
161	R:R:P216	R:R:W220	5.4	No	Yes	3	3	2
162	R:R:I219	R:R:S217	4.64	No	No	0	1	3
163	R:R:E221	R:R:R297	6.98	No	Yes	0	4	3
164	R:R:F223	R:R:L227	12.18	No	No	0	3	4
165	R:R:N225	R:R:T290	5.85	Yes	No	1	5	5
166	R:R:D293	R:R:N225	5.39	No	Yes	1	4	5
167	R:R:N225	R:R:T294	7.31	Yes	No	0	5	5
168	L:L:R10	R:R:N225	6.03	Yes	Yes	1	0	5
169	R:R:M226	R:R:N229	4.21	No	No	0	4	5
170	R:R:M226	R:R:T294	4.52	No	No	0	4	5
171	R:R:F286	R:R:L228	3.65	Yes	No	0	6	5
172	R:R:F291	R:R:N229	4.83	No	No	0	5	5
173	R:R:F233	R:R:L237	4.87	Yes	No	8	8	6
174	R:R:F233	R:R:F279	3.22	Yes	No	8	8	9
175	R:R:F233	R:R:Q287	12.88	Yes	No	0	8	8
176	R:R:L235	R:R:P236	3.28	No	No	0	6	9
177	R:R:F279	R:R:L237	3.65	No	No	8	9	6
178	R:R:I280	R:R:L237	5.71	No	No	0	6	6
179	R:R:I240	R:R:L276	4.28	No	Yes	0	8	7
180	R:R:L276	R:R:T241	5.9	Yes	No	0	7	4
181	R:R:F242	R:R:Q246	10.54	No	No	4	4	4
182	R:R:T244	R:R:V272	4.76	No	No	0	8	7
183	R:R:L276	R:R:T244	5.9	Yes	No	0	7	8
184	R:R:Q246	R:R:Q249	3.84	No	No	0	4	4
185	R:R:I247	R:R:V272	4.61	No	No	0	8	7
186	R:R:Q249	R:R:R252	3.5	No	No	0	4	3
187	R:R:L251	R:R:N254	4.12	Yes	No	9	8	5
188	R:R:E265	R:R:L251	6.63	No	Yes	9	7	8
189	R:R:L251	R:R:T269	4.42	Yes	No	0	8	6
190	R:R:E265	R:R:N254	13.15	No	No	9	7	5
191	R:R:E255	R:R:K258	6.75	No	No	0	4	2
192	R:R:E255	R:R:Q263	3.82	No	No	0	4	4
193	R:R:F259	R:R:Q257	5.86	No	No	0	1	3
194	R:R:K260	R:R:Q263	6.78	No	No	0	3	4
195	R:R:R266	R:R:V270	3.92	No	No	0	4	6
196	R:R:L271	R:R:V335	7.45	No	No	0	8	6
197	R:R:V275	R:R:V331	3.21	No	No	0	8	7
198	R:R:V275	R:R:Y332	11.36	No	Yes	0	8	9
199	R:R:I280	R:R:L276	4.28	No	Yes	0	6	7
200	R:R:C282	R:R:L278	3.17	No	No	0	8	6
201	R:R:L278	R:R:L327	5.54	No	No	0	6	7
202	R:R:F279	R:R:W283	9.02	No	Yes	0	9	9
203	R:R:C282	R:R:S323	3.44	No	No	0	8	4
204	R:R:C282	R:R:N324	9.45	No	No	0	8	9
205	R:R:A321	R:R:W283	7.78	No	Yes	0	8	9
206	R:R:N324	R:R:W283	6.78	No	Yes	0	9	9
207	R:R:L284	R:R:P285	3.28	No	No	0	5	9
208	R:R:I288	R:R:L284	7.14	No	No	0	6	5
209	R:R:M320	R:R:P285	3.35	No	No	0	7	9
210	R:R:F286	R:R:Q287	5.86	Yes	No	0	6	8
211	R:R:F286	R:R:T290	7.78	Yes	No	1	6	5
212	R:R:F286	R:R:S318	5.28	Yes	No	1	6	5
213	L:L:F9	R:R:F286	10.72	No	Yes	0	0	6
214	L:L:R10	R:R:F286	4.28	Yes	Yes	1	0	6
215	R:R:S289	R:R:T314	4.8	No	No	0	5	5
216	L:L:R10	R:R:T290	16.82	Yes	No	1	0	5
217	R:R:F291	R:R:L295	8.53	No	No	0	5	4
218	R:R:D293	R:R:R297	14.29	No	Yes	0	4	3
219	L:L:R10	R:R:D293	9.53	Yes	No	1	0	4
220	R:R:E307	R:R:H296	11.08	No	No	10	3	3
221	L:L:K1	R:R:H296	13.1	Yes	No	10	0	3
222	L:L:K1	R:R:R297	4.95	Yes	Yes	0	0	3
223	L:L:P4	R:R:R297	8.65	No	Yes	0	0	3
224	R:R:D306	R:R:S303	11.78	No	No	0	1	4
225	R:R:C304	R:R:E307	4.56	No	No	0	8	3
226	L:L:K1	R:R:E307	6.75	Yes	No	10	0	3
227	L:L:K1	R:R:D311	4.15	Yes	No	0	0	3
228	L:L:R2	R:R:D311	13.1	Yes	No	0	0	3
229	L:L:S7	R:R:T314	3.2	No	No	0	0	5
230	L:L:R10	R:R:T314	9.06	Yes	No	0	0	5
231	L:L:R2	R:R:Q315	5.84	Yes	Yes	1	0	4
232	L:L:S7	R:R:S318	6.52	No	No	1	0	5
233	L:L:P8	R:R:S318	5.34	Yes	No	1	0	5
234	R:R:F319	R:R:Y322	6.19	Yes	Yes	1	5	7
235	L:L:P8	R:R:F319	7.22	Yes	Yes	1	0	5
236	L:L:P8	R:R:Y322	8.34	Yes	Yes	1	0	7
237	L:L:F9	R:R:Y322	10.32	No	Yes	0	0	7
238	R:R:N324	R:R:N328	12.26	No	Yes	0	9	9
239	R:R:N328	R:R:Y332	4.65	Yes	Yes	2	9	9
240	R:R:F339	R:R:V333	9.18	No	Yes	2	8	7
241	R:R:K337	R:R:R340	3.71	No	No	0	4	8
242	L:L:F6	L:L:R2	13.9	Yes	Yes	1	0	0
243	L:L:F6	L:L:P3	8.67	Yes	No	1	0	0
244	L:L:P8	L:L:S7	5.34	Yes	No	1	0	0
245	R:R:A100	R:R:N75	3.13	No	No	0	8	9
246	R:R:M139	R:R:S189	3.07	No	No	0	6	7
247	R:R:I153	R:R:V239	3.07	No	Yes	0	6	6
248	R:R:K161	R:R:S164	3.06	Yes	No	0	6	4
249	R:R:C326	R:R:E74	3.04	No	No	0	8	8
250	R:R:F82	R:R:G97	3.01	Yes	No	0	7	6
251	R:R:M198	R:R:T209	3.01	Yes	No	0	6	5
252	R:R:M245	R:R:T241	3.01	No	No	0	3	4
253	R:R:M248	R:R:T244	3.01	No	No	0	4	8
254	R:R:M248	R:R:T269	3.01	No	No	0	4	6
255	R:R:G166	R:R:R169	3	No	Yes	0	4	6
256	R:R:L53	R:R:V312	2.98	No	No	0	3	2
257	R:R:L70	R:R:V66	2.98	No	No	0	5	5
258	R:R:L73	R:R:V69	2.98	No	No	0	4	4
259	R:R:N119	R:R:S118	2.98	No	No	0	4	4
260	R:R:L218	R:R:V222	2.98	No	No	0	2	3
261	R:R:I213	R:R:M192	2.92	Yes	No	0	4	4
262	R:R:Q305	R:R:S303	2.89	No	No	0	3	4
263	R:R:I316	R:R:L56	2.85	No	Yes	0	5	3
264	R:R:I137	R:R:L106	2.85	No	No	0	6	7
265	R:R:I288	R:R:L292	2.85	No	No	0	6	5
266	R:R:I310	R:R:L292	2.85	No	No	0	5	5
267	R:R:L273	R:R:M248	2.83	No	No	0	5	4
268	R:R:M256	R:R:N253	2.8	No	No	0	4	4
269	R:R:H85	R:R:V346	2.77	Yes	No	0	5	5
270	L:L:F6	R:R:A210	2.77	Yes	No	0	0	2
271	R:R:L295	R:R:L301	2.77	No	No	0	4	1
272	R:R:D122	R:R:L124	2.71	No	No	0	5	1
273	R:R:E127	R:R:M198	2.71	No	Yes	0	3	6
274	R:R:D154	R:R:L157	2.71	Yes	No	0	8	5
275	R:R:D306	R:R:L301	2.71	No	No	0	1	1
276	R:R:P111	R:R:W65	2.7	No	No	0	9	4
277	R:R:P191	R:R:W220	2.7	No	Yes	0	7	2
278	R:R:E221	R:R:L218	2.65	No	No	0	4	2
279	R:R:F63	R:R:I59	2.51	No	No	0	4	5
280	R:R:F233	R:R:L284	2.44	Yes	No	0	8	5
281	R:R:L271	R:R:R267	2.43	No	No	0	8	7
282	R:R:L227	R:R:Y142	2.34	No	Yes	0	4	7
283	R:R:E51	R:R:W52	2.18	No	No	0	5	3
284	R:R:R267	R:R:R340	2.13	No	No	0	7	8
285	R:R:C47	R:R:P48	1.88	No	No	0	7	7
286	R:R:A317	R:R:P285	1.87	No	No	0	7	9
287	R:R:G170	R:R:V91	1.84	No	Yes	0	6	6
288	R:R:G336	R:R:V335	1.84	No	No	0	8	6
289	R:R:A71	R:R:C326	1.81	No	No	0	8	8
290	R:R:A107	R:R:A71	1.79	No	No	0	6	8
291	R:R:G232	R:R:I145	1.76	No	No	0	6	8
292	R:R:G126	R:R:M198	1.75	No	Yes	0	8	6
293	R:R:A102	R:R:S143	1.71	No	No	0	8	7
294	R:R:A102	R:R:S144	1.71	No	No	0	8	9
295	R:R:A135	R:R:S189	1.71	No	No	0	6	7
296	R:R:C184	R:R:V180	1.71	No	No	0	4	4
297	R:R:G183	R:R:L186	1.71	No	No	0	4	4
298	R:R:C243	R:R:V239	1.71	No	Yes	0	7	6
299	R:R:A92	R:R:T90	1.68	No	No	0	7	7
300	R:R:C89	R:R:I94	1.64	No	Yes	0	5	6
301	R:R:S80	R:R:V81	1.62	No	Yes	0	4	8
302	R:R:S214	R:R:V212	1.62	No	No	0	4	4
303	R:R:S238	R:R:V239	1.62	No	Yes	0	4	6
304	R:R:V270	R:R:V274	1.6	No	No	0	6	5
305	R:R:V274	R:R:V331	1.6	No	No	0	5	7
306	R:R:C83	R:R:L84	1.59	No	No	0	3	4
307	R:R:C108	R:R:L104	1.59	No	No	0	5	7
308	R:R:A268	R:R:L251	1.58	No	Yes	0	8	8
309	R:R:I313	R:R:S289	1.55	No	No	0	5	5
310	R:R:I334	R:R:V78	1.54	No	No	0	6	8
311	R:R:I136	R:R:V132	1.54	No	No	0	5	4
312	R:R:K86	R:R:S87	1.53	No	No	0	5	5
313	R:R:I59	R:R:T58	1.52	No	No	0	5	6
314	R:R:I262	R:R:T264	1.52	No	No	0	2	4
315	R:R:L188	R:R:V231	1.49	No	No	0	5	5
316	R:R:N207	R:R:S202	1.49	No	No	0	6	2
317	R:R:L298	R:R:V222	1.49	No	No	0	1	3
318	R:R:L227	R:R:V231	1.49	No	No	0	4	5
319	R:R:L73	R:R:T72	1.47	No	No	0	4	6
320	R:R:L129	R:R:T128	1.47	No	No	0	5	2
321	R:R:I105	R:R:L104	1.43	No	No	0	7	7
322	R:R:I300	R:R:L295	1.43	No	No	0	1	4
323	R:R:I300	R:R:L298	1.43	No	No	0	1	1
324	R:R:D306	R:R:I309	1.4	No	No	0	1	3
325	R:R:L273	R:R:L277	1.38	No	No	0	5	5
326	R:R:N253	R:R:N254	1.36	No	No	0	4	5
327	R:R:M256	R:R:Q257	1.36	No	No	0	4	3
328	R:R:K260	R:R:Q257	1.36	No	No	0	3	3
329	R:R:E200	R:R:K199	1.35	No	No	0	2	4
330	R:R:A101	R:R:W182	1.3	No	Yes	0	5	9
331	R:R:M168	R:R:R167	1.24	No	No	0	3	3
332	R:R:S217	R:R:W220	1.24	No	Yes	0	3	2
333	R:R:S343	R:R:W344	1.24	No	No	0	6	4
334	R:R:F233	R:R:L234	1.22	Yes	No	0	8	5
335	R:R:L176	R:R:R172	1.21	No	No	0	3	4
336	R:R:Q348	R:R:W344	1.1	No	No	0	4	4
337	R:R:Y177	R:R:Y95	0.99	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L56	4.2275	4	1	3
2	R:R:N57	6.8575	4	1	5
3	R:R:V81	4.49	4	0	8
4	R:R:F82	4.19	5	2	7
5	R:R:H85	9.525	4	0	5
6	R:R:V91	6.125	4	5	6
7	R:R:I94	3.465	4	0	6
8	R:R:Y95	6.412	5	5	7
9	R:R:D103	6.585	4	0	9
10	R:R:F121	8.0325	4	1	4
11	R:R:W123	9.548	5	7	8
12	R:R:F125	9.735	4	0	7
13	R:R:Y142	4.1025	4	0	7
14	R:R:F147	9.935	4	6	8
15	R:R:D154	8.5725	4	5	8
16	R:R:Y156	5.95333	6	4	8
17	R:R:K161	5.7925	4	4	6
18	R:R:R169	8.695	4	5	6
19	R:R:W182	6.6875	4	6	9
20	R:R:F195	7.9525	4	3	4
21	R:R:M198	3.072	5	7	6
22	R:R:Y201	7.87	4	1	1
23	R:R:E204	5.444	5	1	2
24	R:R:I213	6.8175	4	3	4
25	R:R:Y215	10.064	5	3	5
26	R:R:W220	5.008	5	3	2
27	R:R:N225	6.145	4	1	5
28	R:R:F233	4.926	5	8	8
29	R:R:V239	3.8825	4	0	6
30	R:R:L251	4.1875	4	9	8
31	R:R:L276	5.09	4	0	7
32	R:R:W283	7.038	5	0	9
33	R:R:F286	6.26167	6	1	6
34	R:R:R297	8.7175	4	0	3
35	R:R:Q315	5.77	5	1	4
36	R:R:F319	8.024	5	1	5
37	R:R:Y322	7.102	5	1	7
38	R:R:N328	8.3075	4	2	9
39	R:R:Y332	5.69667	6	2	9
40	R:R:V333	5.97	4	2	7
41	L:L:K1	7.2375	4	10	0
42	L:L:R2	8.40857	7	1	0
43	L:L:F6	10.124	5	1	0
44	L:L:P8	9.302	5	1	0
45	L:L:R10	9.144	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	R:R:D311	13.1761	4.15	Yes	No	0	0	3
2	L:L:R2	R:R:D311	12.9227	13.1	Yes	No	0	0	3
3	L:L:R2	R:R:Q315	26.6901	5.84	Yes	Yes	1	0	4
4	R:R:Q315	R:R:Q60	48.3462	6.4	Yes	No	1	4	5
5	R:R:N57	R:R:Q315	11.6119	5.28	Yes	Yes	1	5	4
6	R:R:F319	R:R:Q60	60.7048	7.03	Yes	No	1	5	5
7	R:R:F319	R:R:I117	14.4971	6.28	Yes	No	0	5	5
8	R:R:I117	R:R:P61	12.8146	3.39	No	No	0	5	8
9	R:R:A114	R:R:L64	12.8146	3.15	No	No	0	7	6
10	R:R:F319	R:R:L64	14.6187	13.4	Yes	No	0	5	6
11	R:R:A114	R:R:W65	11.0037	3.89	No	No	0	7	4
12	L:L:K1	R:R:R297	16.8553	4.95	Yes	Yes	0	0	3
13	R:R:D293	R:R:R297	23.2575	14.29	No	Yes	0	4	3
14	L:L:R10	R:R:D293	22.4602	9.53	Yes	No	1	0	4
15	L:L:R10	R:R:F286	32.2376	4.28	Yes	Yes	1	0	6
16	L:L:F9	R:R:F286	37.9033	10.72	No	Yes	0	0	6
17	L:L:F9	R:R:Y322	69.0462	10.32	No	Yes	0	0	7
18	R:R:F319	R:R:Y322	54.7789	6.19	Yes	Yes	1	5	7
19	L:L:F9	R:R:L141	54.8498	9.74	No	No	0	0	7
20	R:R:L141	R:R:W283	56.0796	4.56	No	Yes	0	7	9
21	R:R:N324	R:R:W283	52.2078	6.78	No	Yes	0	9	9
22	R:R:N324	R:R:N328	48.9645	12.26	No	Yes	0	9	9
23	R:R:D103	R:R:N328	23.7238	8.08	Yes	Yes	0	9	9
24	R:R:D103	R:R:N75	11.8146	9.42	Yes	No	0	9	9
25	R:R:I137	R:R:Y322	13.3417	3.63	No	Yes	0	6	7
26	R:R:I137	R:R:L106	10.7267	2.85	No	No	0	6	7
27	R:R:N328	R:R:Y332	29.9199	4.65	Yes	Yes	2	9	9
28	R:R:L96	R:R:Y332	22.6697	3.52	No	Yes	2	8	9
29	R:R:F82	R:R:L96	11.3382	3.65	Yes	No	2	7	8
30	R:R:F339	R:R:V81	12.595	7.87	No	Yes	0	8	8
31	R:R:L96	R:R:V333	10.3551	5.96	No	Yes	2	8	7
32	R:R:F286	R:R:Q287	68.803	5.86	Yes	No	0	6	8
33	R:R:F233	R:R:Q287	68.4246	12.88	Yes	No	0	8	8
34	R:R:F233	R:R:L237	62.171	4.87	Yes	No	8	8	6
35	R:R:I280	R:R:L237	100	5.71	No	No	0	6	6
36	R:R:I280	R:R:L276	98.8209	4.28	No	Yes	0	6	7
37	R:R:I240	R:R:L276	70.0497	4.28	No	Yes	0	8	7
38	R:R:I240	R:R:S152	68.7084	9.29	No	No	0	8	9
39	R:R:C243	R:R:S152	67.3604	3.44	No	No	0	7	9
40	R:R:C243	R:R:Y156	60.5189	5.38	No	Yes	0	7	8
41	R:R:L157	R:R:Y156	46.2786	3.52	No	Yes	0	5	8
42	R:R:D154	R:R:L157	43.569	2.71	Yes	No	0	8	5
43	R:R:D154	R:R:Y95	34.5518	12.64	Yes	Yes	5	8	7
44	R:R:A174	R:R:Y95	25.7509	4	No	Yes	0	7	7
45	R:R:A174	R:R:I94	24.1866	3.25	No	Yes	0	7	6
46	R:R:C89	R:R:I94	19.4534	1.64	No	Yes	0	5	6
47	R:R:C89	R:R:E93	17.8621	6.08	No	No	0	5	7
48	R:R:E93	R:R:K342	13.0477	8.1	No	No	0	7	5
49	R:R:H85	R:R:K342	11.5139	18.34	Yes	No	0	5	5
50	R:R:E221	R:R:R297	17.4432	6.98	No	Yes	0	4	3
51	R:R:E221	R:R:Y215	14.2505	10.1	No	Yes	0	4	5
52	R:R:I213	R:R:Y215	10.051	13.3	Yes	Yes	3	4	5
53	R:R:D103	R:R:S144	12.8315	4.42	Yes	No	0	9	9
54	R:R:N134	R:R:R196	10.1152	19.28	No	No	0	5	4
55	R:R:T116	R:R:W113	12.7538	4.85	No	No	0	5	6
56	R:R:F286	R:R:S318	30.3287	5.28	Yes	No	1	6	5
57	L:L:P8	R:R:S318	29.4672	5.34	Yes	No	1	0	5
58	L:L:P8	R:R:W113	22.3555	20.27	Yes	No	0	0	6
59	L:L:P8	R:R:F319	29.3557	7.22	Yes	Yes	1	0	5
60	L:L:F6	L:L:R2	14.1728	13.9	Yes	Yes	1	0	0
61	R:R:L276	R:R:T244	31.5011	5.9	Yes	No	0	7	8
62	L:L:F6	L:L:P3	18.5175	8.67	Yes	No	1	0	0
63	R:R:N225	R:R:T294	18.5006	7.31	Yes	No	0	5	5
64	R:R:M226	R:R:T294	16.4364	4.52	No	No	0	4	5
65	R:R:M226	R:R:N229	14.3721	4.21	No	No	0	4	5
66	R:R:F291	R:R:N229	12.3078	4.83	No	No	0	5	5
67	R:R:M248	R:R:T244	25.4367	3.01	No	No	0	4	8
68	R:R:M248	R:R:T269	20.7642	3.01	No	No	0	4	6
69	R:R:L251	R:R:T269	19.1932	4.42	Yes	No	0	8	6
70	R:R:L251	R:R:N254	14.4025	4.12	Yes	No	9	8	5
71	R:R:N253	R:R:N254	12.8281	1.36	No	No	0	4	5
72	R:R:M256	R:R:N253	11.2234	2.8	No	No	0	4	4
73	R:R:A102	R:R:S143	11.4058	1.71	No	No	0	8	7
74	R:R:F279	R:R:W283	42.1197	9.02	No	Yes	0	9	9
75	R:R:F279	R:R:L237	38.9979	3.65	No	No	8	9	6
76	R:R:T116	R:R:W123	11.595	4.85	No	Yes	0	5	8
77	R:R:A102	R:R:S144	12.0004	1.71	No	No	0	8	9
78	R:R:L56	R:R:Q60	11.1862	3.99	Yes	No	1	3	5
79	R:R:F121	R:R:Q315	11.2842	4.68	Yes	Yes	1	4	4
80	L:L:F6	R:R:F121	10.1591	13.93	Yes	Yes	1	0	4
81	L:L:R10	R:R:N225	10.3787	6.03	Yes	Yes	1	0	5
82	R:R:F291	R:R:L295	10.5308	8.53	No	No	0	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L53	R:R:V50	7.45	0	No	No	3	4	1	2
L:L:R2	R:R:L53	10.93	1	Yes	No	0	3	0	1
R:R:L56	R:R:Q60	3.99	1	Yes	No	3	5	2	2
R:R:L56	R:R:Q315	6.65	1	Yes	Yes	3	4	2	1
R:R:N120	R:R:N57	9.54	1	No	Yes	3	5	2	2
R:R:F121	R:R:N57	6.04	1	Yes	Yes	4	5	1	2
R:R:E204	R:R:N57	6.57	1	Yes	Yes	2	5	1	2
R:R:N57	R:R:Q315	5.28	1	Yes	Yes	5	4	2	1
R:R:Q315	R:R:Q60	6.4	1	Yes	No	4	5	1	2
R:R:F319	R:R:Q60	7.03	1	Yes	No	5	5	1	2
R:R:F319	R:R:L64	13.4	1	Yes	No	5	6	1	2
R:R:L110	R:R:Y322	7.03	0	No	Yes	8	7	2	1
R:R:T116	R:R:W113	4.85	0	No	No	5	6	2	1
R:R:N134	R:R:W113	5.65	0	No	No	5	6	2	1
L:L:P8	R:R:W113	20.27	1	Yes	No	0	6	0	1
R:R:F319	R:R:I117	6.28	1	Yes	No	5	5	1	2
R:R:E204	R:R:N120	3.94	1	Yes	No	2	3	1	2
R:R:H206	R:R:N120	10.2	1	No	No	2	3	2	2
R:R:F121	R:R:Q315	4.68	1	Yes	Yes	4	4	1	1
L:L:R2	R:R:F121	7.48	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:F121	13.93	1	Yes	Yes	0	4	0	1
R:R:N134	R:R:R196	19.28	0	No	No	5	4	2	1
R:R:I137	R:R:Y322	3.63	0	No	Yes	6	7	2	1
R:R:L141	R:R:Y142	7.03	0	No	Yes	7	7	1	2
R:R:L141	R:R:W283	4.56	0	No	Yes	7	9	1	2
L:L:F9	R:R:L141	9.74	0	No	No	0	7	0	1
R:R:L228	R:R:Y142	3.52	0	No	Yes	5	7	2	2
R:R:I213	R:R:R196	7.52	3	Yes	No	4	4	1	1
L:L:G5	R:R:R196	4.5	3	No	No	0	4	0	1
R:R:K199	R:R:V212	10.62	1	No	No	4	4	1	1
L:L:P3	R:R:K199	6.69	1	No	No	0	4	0	1
R:R:D203	R:R:Y201	12.64	0	No	Yes	2	1	2	1
R:R:E204	R:R:Y201	3.37	1	Yes	Yes	2	1	1	1
L:L:R2	R:R:Y201	4.12	1	Yes	Yes	0	1	0	1
L:L:F6	R:R:Y201	11.35	1	Yes	Yes	0	1	0	1
R:R:E204	R:R:H206	9.85	1	Yes	No	2	2	1	2
L:L:R2	R:R:E204	3.49	1	Yes	Yes	0	2	0	1
L:L:P3	R:R:V212	7.07	1	No	No	0	4	0	1
R:R:I213	R:R:Y215	13.3	3	Yes	Yes	4	5	1	2
L:L:G5	R:R:I213	3.53	3	No	Yes	0	4	0	1
R:R:E221	R:R:Y215	10.1	0	No	Yes	4	5	2	2
R:R:E221	R:R:R297	6.98	0	No	Yes	4	3	2	1
R:R:N225	R:R:T290	5.85	1	Yes	No	5	5	1	1
R:R:D293	R:R:N225	5.39	1	No	Yes	4	5	1	1
R:R:N225	R:R:T294	7.31	1	Yes	No	5	5	1	2
L:L:R10	R:R:N225	6.03	1	Yes	Yes	0	5	0	1
R:R:F286	R:R:L228	3.65	1	Yes	No	6	5	1	2
R:R:F286	R:R:Q287	5.86	1	Yes	No	6	8	1	2
R:R:F286	R:R:T290	7.78	1	Yes	No	6	5	1	1
R:R:F286	R:R:S318	5.28	1	Yes	No	6	5	1	1
L:L:F9	R:R:F286	10.72	0	No	Yes	0	6	0	1
L:L:R10	R:R:F286	4.28	1	Yes	Yes	0	6	0	1
R:R:S289	R:R:T314	4.8	0	No	No	5	5	2	1
L:L:R10	R:R:T290	16.82	1	Yes	No	0	5	0	1
R:R:D293	R:R:R297	14.29	1	No	Yes	4	3	1	1
L:L:R10	R:R:D293	9.53	1	Yes	No	0	4	0	1
R:R:E307	R:R:H296	11.08	10	No	No	3	3	1	1
L:L:K1	R:R:H296	13.1	10	Yes	No	0	3	0	1
L:L:K1	R:R:R297	4.95	10	Yes	Yes	0	3	0	1
L:L:P4	R:R:R297	8.65	0	No	Yes	0	3	0	1
R:R:C304	R:R:E307	4.56	0	No	No	8	3	2	1
L:L:K1	R:R:E307	6.75	10	Yes	No	0	3	0	1
L:L:K1	R:R:D311	4.15	10	Yes	No	0	3	0	1
L:L:R2	R:R:D311	13.1	1	Yes	No	0	3	0	1
L:L:S7	R:R:T314	3.2	1	No	No	0	5	0	1
L:L:R10	R:R:T314	9.06	1	Yes	No	0	5	0	1
L:L:R2	R:R:Q315	5.84	1	Yes	Yes	0	4	0	1
L:L:S7	R:R:S318	6.52	1	No	No	0	5	0	1
L:L:P8	R:R:S318	5.34	1	Yes	No	0	5	0	1
R:R:F319	R:R:Y322	6.19	1	Yes	Yes	5	7	1	1
L:L:P8	R:R:F319	7.22	1	Yes	Yes	0	5	0	1
L:L:P8	R:R:Y322	8.34	1	Yes	Yes	0	7	0	1
L:L:F9	R:R:Y322	10.32	0	No	Yes	0	7	0	1
R:R:L53	R:R:V312	2.98	0	No	No	3	2	1	2
R:R:I213	R:R:M192	2.92	3	Yes	No	4	4	1	2
L:L:F6	R:R:A210	2.77	1	Yes	No	0	2	0	1
R:R:S214	R:R:V212	1.62	0	No	No	4	4	2	1
R:R:E200	R:R:K199	1.35	0	No	No	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F6I_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	300
Number of Links	337
Number of Hubs	45
Number of Links mediated by Hubs	169
Number of Communities	10
Number of Nodes involved in Communities	65
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	65175
Length Of Smallest Path	3
Average Path Length	15.1826
Length of Longest Path	33
Minimum Path Strength	1.17
Average Path Strength	6.45921
Maximum Path Strength	15.855
Minimum Path Correlation	0.7
Average Path Correlation	0.932529
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	50.1768
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.4852
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • G protein activity • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • neuropeptide signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • hormone-mediated signaling pathway • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • sensory perception of itch • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • Golgi apparatus • postsynapse • postsynaptic cytosol • molecular function inhibitor activity • peptidase regulator activity • enzyme inhibitor activity • cysteine-type endopeptidase inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • hormone activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • transition metal ion binding • zinc ion binding • heparin binding • glycosaminoglycan binding • sulfur compound binding • positive regulation of cytosolic calcium ion concentration • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • regulation of response to external stimulus • negative regulation of biological process • regulation of response to wounding • regulation of coagulation • regulation of response to stress • regulation of hemostasis • negative regulation of response to stimulus • negative regulation of wound healing • regulation of blood coagulation • negative regulation of blood coagulation • negative regulation of response to wounding • negative regulation of hemostasis • negative regulation of coagulation • negative regulation of response to external stimulus • regulation of wound healing • negative regulation of multicellular organismal process • negative regulation of proteolysis • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • regulation of proteolysis • proteolysis • negative regulation of cellular process • metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • defense response • inflammatory response • cell adhesion • regulation of cell adhesion • negative regulation of cell adhesion • extracellular matrix • external encapsulating structure • blood microparticle • membrane-enclosed lumen • intracellular organelle lumen • endoplasmic reticulum lumen • organelle lumen • endoplasmic reticulum • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • platelet alpha granule • platelet alpha granule lumen • phosphoric ester hydrolase activity • phospholipase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • glycerophospholipase activity • C-type glycerophospholipase activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • lipase activity • protease binding • protein heterodimerization activity • protein dimerization activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • bradykinin receptor activity • angiotensin receptor binding • type 1 angiotensin receptor binding • organic anion transport • carboxylic acid transport • arachidonate transport • lipid localization • lipid transport • organic acid transport • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • smooth muscle contraction • muscle contraction • muscle system process • vasoconstriction • intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • regulation of cellular response to stress • regulation of response to osmotic stress • regulation of cellular response to osmotic stress • negative regulation of apoptotic signaling pathway • intrinsic apoptotic signaling pathway • negative regulation of signal transduction by p53 class mediator • negative regulation of programmed cell death • regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • negative regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to osmotic stress • intrinsic apoptotic signaling pathway by p53 class mediator • regulation of apoptotic signaling pathway • negative regulation of signaling • negative regulation of intracellular signal transduction • cellular response to chemical stress • regulation of intrinsic apoptotic signaling pathway • negative regulation of cell communication • cellular response to stress • regulation of intracellular signal transduction • regulation of signal transduction by p53 class mediator • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to osmotic stress • signal transduction by p53 class mediator • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • cellular response to osmotic stress • negative regulation of signal transduction • apoptotic signaling pathway • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • regulation of intrinsic apoptotic signaling pathway by p53 class mediator • regulation of vascular permeability • regulation of system process • regulation of blood circulation • regulation of vasoconstriction • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • response to salt stress • endosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30411
Sequence	>7F6I_nogp_Chain_R C P Q V E W L G W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H K S S C T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N F D W L F G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K T M S M G R M R G V R W A K L Y S L V I W G C T L L L S S P M L V F R T M K E Y S D E G H N V T A C V I S Y P S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K F K E I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G I L S S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R F R K K S W E V Y Q G V C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Kallidin
UniProt	P01042
Sequence	>7F6I_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F2O	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-10-13	doi.org/10.1038/s41594-021-00645-y
	7F2O (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-		2.9	2021-10-13	doi.org/10.1038/s41594-021-00645-y
	7F6H	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-	Gq/β1/γ2	2.9	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6H (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-		2.9	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6I	A	Peptide	Bradykinin	BK₂	Homo sapiens	Kallidin	-	Gq/β1/γ2	2.8	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6I (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Kallidin	-		2.8	2022-01-05	doi.org/10.1038/s41467-022-28399-1

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