psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C304	R:R:C47	7.28	No	No	5	8	7
2	R:R:C47	R:R:R308	5.57	No	No	5	7	1
3	R:R:L53	R:R:V50	10.43	No	No	0	3	4
4	R:R:R308	R:R:V50	6.54	No	No	0	1	4
5	R:R:W52	R:R:W55	3.75	No	No	0	3	4
6	R:R:V312	R:R:W52	3.68	No	No	0	2	3
7	R:R:L53	R:R:V312	5.96	No	No	0	3	2
8	L:L:R1	R:R:L53	4.86	Yes	No	0	0	3
9	R:R:I59	R:R:W55	7.05	No	No	0	5	4
10	R:R:L56	R:R:Q315	5.32	No	Yes	0	3	4
11	R:R:I316	R:R:L56	5.71	No	No	0	5	3
12	R:R:N120	R:R:N57	5.45	No	Yes	0	3	5
13	R:R:F121	R:R:N57	6.04	Yes	Yes	2	4	5
14	R:R:E204	R:R:N57	5.26	Yes	Yes	0	2	5
15	R:R:N57	R:R:Q315	5.28	Yes	Yes	2	5	4
16	R:R:L64	R:R:Q60	6.65	Yes	No	1	6	5
17	R:R:F319	R:R:Q60	11.71	Yes	No	1	5	5
18	R:R:P61	R:R:P62	5.84	No	No	0	8	4
19	R:R:I117	R:R:P61	3.39	No	No	0	5	8
20	R:R:P61	R:R:S118	5.34	No	No	0	8	4
21	R:R:L110	R:R:L64	6.92	Yes	Yes	1	8	6
22	R:R:A114	R:R:L64	3.15	No	Yes	0	7	6
23	R:R:F319	R:R:L64	10.96	Yes	Yes	1	5	6
24	R:R:F68	R:R:W65	4.01	Yes	No	0	7	4
25	R:R:A114	R:R:W65	5.19	No	No	0	7	4
26	R:R:L110	R:R:L67	4.15	Yes	No	0	8	7
27	R:R:C326	R:R:L67	3.17	Yes	No	0	8	7
28	R:R:F68	R:R:T72	3.89	Yes	No	0	7	6
29	R:R:F68	R:R:L110	3.65	Yes	Yes	1	7	8
30	R:R:F68	R:R:P111	8.67	Yes	No	1	7	9
31	R:R:C326	R:R:L70	4.76	Yes	No	0	8	5
32	R:R:C326	R:R:E74	4.56	Yes	No	0	8	8
33	R:R:E74	R:R:P329	6.29	No	No	0	8	9
34	R:R:D103	R:R:N75	6.73	Yes	No	0	9	9
35	R:R:N75	R:R:P329	8.15	No	No	0	9	9
36	R:R:I76	R:R:L104	4.28	No	No	0	3	7
37	R:R:F77	R:R:V81	6.55	No	Yes	6	6	8
38	R:R:F339	R:R:F77	6.43	Yes	No	6	8	6
39	R:R:F77	R:R:S343	5.28	No	No	0	6	6
40	R:R:F82	R:R:V78	5.24	Yes	No	0	7	8
41	R:R:A100	R:R:V78	3.39	No	No	0	8	8
42	R:R:V333	R:R:V78	3.21	No	No	0	7	8
43	R:R:A100	R:R:L79	3.15	No	No	0	8	7
44	R:R:S80	R:R:V81	3.23	No	Yes	0	4	8
45	R:R:F339	R:R:V81	7.87	Yes	Yes	6	8	8
46	R:R:E93	R:R:F82	10.49	Yes	Yes	0	7	7
47	R:R:F339	R:R:F82	6.43	Yes	Yes	0	8	7
48	R:R:L84	R:R:V346	4.47	No	No	0	4	5
49	R:R:H85	R:R:S87	8.37	No	No	0	5	5
50	R:R:H85	R:R:K342	22.27	No	No	0	5	5
51	R:R:E345	R:R:H85	12.31	No	No	0	5	5
52	R:R:E93	R:R:T90	8.47	Yes	No	0	7	7
53	R:R:V91	R:R:Y95	5.05	Yes	Yes	3	6	7
54	R:R:D154	R:R:V91	4.38	No	Yes	3	8	6
55	R:R:R169	R:R:V91	3.92	Yes	Yes	3	6	6
56	R:R:E93	R:R:K342	9.45	Yes	No	0	7	5
57	R:R:I94	R:R:V171	4.61	No	No	7	6	3
58	R:R:A174	R:R:I94	3.25	No	No	0	7	6
59	R:R:I94	R:R:K175	4.36	No	No	7	6	2
60	R:R:L150	R:R:Y95	7.03	No	Yes	0	6	7
61	R:R:D154	R:R:Y95	8.05	No	Yes	3	8	7
62	R:R:A174	R:R:Y95	4	No	Yes	0	7	7
63	R:R:L96	R:R:Y332	3.52	No	Yes	0	8	9
64	R:R:L96	R:R:V333	5.96	No	No	0	8	7
65	R:R:F147	R:R:N98	10.87	Yes	No	3	8	9
66	R:R:N98	R:R:S178	8.94	No	No	3	9	7
67	R:R:N98	R:R:W182	6.78	No	Yes	3	9	9
68	R:R:L99	R:R:N328	4.12	No	Yes	0	9	9
69	R:R:D103	R:R:S144	5.89	Yes	No	0	9	9
70	R:R:D103	R:R:S325	4.42	Yes	No	0	9	8
71	R:R:D103	R:R:N328	8.08	Yes	Yes	0	9	9
72	R:R:I105	R:R:N140	12.74	No	No	0	7	8
73	R:R:L106	R:R:N140	4.12	No	No	0	7	8
74	R:R:L106	R:R:Y322	5.86	No	Yes	0	7	7
75	R:R:G109	R:R:I137	3.53	No	No	0	6	6
76	R:R:L110	R:R:P111	3.28	Yes	No	1	8	9
77	R:R:L110	R:R:Y322	4.69	Yes	Yes	1	8	7
78	R:R:F112	R:R:F125	8.57	No	Yes	0	6	7
79	R:R:F112	R:R:V133	13.11	No	No	0	6	5
80	R:R:T116	R:R:W113	6.06	No	No	0	5	6
81	R:R:N134	R:R:W113	7.91	No	No	0	5	6
82	L:L:P7	R:R:W113	8.11	Yes	No	0	0	6
83	R:R:F125	R:R:I115	8.79	Yes	No	0	7	4
84	R:R:T116	R:R:W123	4.85	No	Yes	0	5	8
85	R:R:F121	R:R:I117	3.77	Yes	No	0	4	5
86	R:R:F319	R:R:I117	3.77	Yes	No	0	5	5
87	R:R:H206	R:R:N120	19.13	No	No	0	2	3
88	R:R:F121	R:R:Q315	7.03	Yes	Yes	2	4	4
89	L:L:R1	R:R:F121	7.48	Yes	Yes	2	0	4
90	L:L:F5	R:R:F121	13.93	Yes	Yes	2	0	4
91	R:R:D122	R:R:V208	5.84	No	No	0	5	1
92	R:R:F125	R:R:W123	11.02	Yes	Yes	0	7	8
93	R:R:C130	R:R:W123	6.53	No	Yes	8	9	8
94	R:R:M198	R:R:W123	5.82	No	Yes	0	6	8
95	R:R:C211	R:R:W123	13.06	No	Yes	8	9	8
96	R:R:E127	R:R:R131	9.3	No	No	0	3	7
97	R:R:E127	R:R:M198	5.41	No	No	0	3	6
98	R:R:C130	R:R:C211	7.28	No	No	8	9	9
99	R:R:N134	R:R:R196	24.1	No	Yes	0	5	4
100	R:R:A135	R:R:L193	4.73	No	No	0	6	5
101	R:R:I137	R:R:Y322	4.84	No	Yes	0	6	7
102	R:R:S138	R:R:S189	4.89	No	No	0	5	7
103	R:R:M139	R:R:T185	4.52	No	No	0	6	8
104	R:R:M139	R:R:S189	4.6	No	No	0	6	7
105	R:R:L141	R:R:W283	5.69	No	Yes	0	7	9
106	L:L:F8	R:R:L141	10.96	Yes	No	0	0	7
107	R:R:L188	R:R:Y142	3.52	No	No	0	5	7
108	R:R:L227	R:R:Y142	5.86	No	No	0	4	7
109	R:R:S143	R:R:W182	4.94	No	Yes	0	7	9
110	R:R:S143	R:R:T185	9.59	No	No	0	7	8
111	R:R:I145	R:R:P236	3.39	No	No	0	8	9
112	R:R:I145	R:R:W283	7.05	No	Yes	0	8	9
113	R:R:C146	R:R:I181	3.27	No	No	0	5	7
114	R:R:F147	R:R:S178	3.96	Yes	No	3	8	7
115	R:R:F147	R:R:I181	10.05	Yes	No	0	8	7
116	R:R:F147	R:R:W182	12.03	Yes	Yes	3	8	9
117	R:R:F279	R:R:L148	4.87	Yes	No	0	9	8
118	R:R:L148	R:R:N328	4.12	No	Yes	0	8	9
119	R:R:L148	R:R:Y332	8.21	No	Yes	0	8	9
120	R:R:M149	R:R:V239	9.13	No	Yes	0	7	6
121	R:R:V151	R:R:Y332	6.31	No	Yes	0	9	9
122	R:R:I240	R:R:S152	7.74	No	No	0	8	9
123	R:R:C243	R:R:S152	3.44	No	No	0	7	9
124	R:R:D154	R:R:R169	13.1	No	Yes	3	8	6
125	R:R:I247	R:R:R155	3.76	Yes	No	0	8	9
126	R:R:R155	R:R:Y332	6.17	No	Yes	0	9	9
127	R:R:L157	R:R:Y156	3.52	No	Yes	0	5	8
128	R:R:V160	R:R:Y156	10.09	Yes	Yes	4	7	8
129	R:R:K161	R:R:Y156	5.97	No	Yes	0	6	8
130	R:R:F242	R:R:Y156	6.19	No	Yes	4	4	8
131	R:R:C243	R:R:Y156	4.03	No	Yes	0	7	8
132	R:R:Q246	R:R:Y156	4.51	No	Yes	4	4	8
133	R:R:L157	R:R:M165	4.24	No	No	0	5	6
134	R:R:A158	R:R:R169	5.53	No	Yes	0	8	6
135	R:R:Q246	R:R:V160	4.3	No	Yes	4	4	7
136	R:R:V160	R:R:V250	6.41	Yes	No	0	7	5
137	R:R:K175	R:R:V171	4.55	No	No	7	2	3
138	R:R:R172	R:R:W173	10	No	No	9	4	4
139	R:R:L176	R:R:R172	4.86	No	No	9	3	4
140	R:R:L176	R:R:W173	3.42	No	No	9	3	4
141	R:R:W173	R:R:Y177	8.68	No	No	0	4	5
142	R:R:P191	R:R:S190	5.34	No	No	0	7	4
143	R:R:M192	R:R:R196	3.72	No	Yes	1	4	4
144	R:R:I213	R:R:M192	4.37	Yes	No	1	4	4
145	R:R:F195	R:R:V194	5.24	No	No	0	4	4
146	R:R:F195	R:R:P216	10.11	No	No	0	4	3
147	R:R:F195	R:R:W220	7.02	No	No	0	4	2
148	R:R:I213	R:R:R196	8.77	Yes	Yes	1	4	4
149	L:L:G4	R:R:R196	4.5	No	Yes	1	0	4
150	R:R:K199	R:R:T197	9.01	No	No	2	4	4
151	R:R:S214	R:R:T197	7.99	No	No	2	4	4
152	R:R:M198	R:R:T209	4.52	No	No	0	6	5
153	R:R:K199	R:R:V212	4.55	No	No	2	4	4
154	R:R:K199	R:R:S214	9.18	No	No	2	4	4
155	R:R:D203	R:R:Y201	8.05	No	Yes	0	2	1
156	R:R:E204	R:R:Y201	3.37	Yes	Yes	0	2	1
157	L:L:F5	R:R:Y201	13.41	Yes	Yes	0	0	1
158	R:R:E204	R:R:H206	8.62	Yes	No	0	2	2
159	L:L:R1	R:R:E204	3.49	Yes	Yes	0	0	2
160	R:R:G205	R:R:H206	3.18	No	No	0	3	2
161	L:L:F5	R:R:A210	4.16	Yes	No	0	0	2
162	L:L:P2	R:R:V212	3.53	No	No	2	0	4
163	L:L:F5	R:R:V212	3.93	Yes	No	2	0	4
164	R:R:I213	R:R:Y215	16.92	Yes	Yes	1	4	5
165	L:L:G4	R:R:I213	3.53	No	Yes	1	0	4
166	R:R:W220	R:R:Y215	5.79	No	Yes	0	2	5
167	R:R:E221	R:R:Y215	10.1	Yes	Yes	1	4	5
168	R:R:T224	R:R:Y215	8.74	No	Yes	0	5	5
169	L:L:P3	R:R:Y215	4.17	No	Yes	1	0	5
170	R:R:E221	R:R:L218	3.98	Yes	No	0	4	2
171	R:R:E221	R:R:R297	3.49	Yes	Yes	1	4	3
172	L:L:P3	R:R:E221	4.72	No	Yes	1	0	4
173	R:R:F223	R:R:L227	8.53	No	No	0	3	4
174	R:R:N225	R:R:T290	5.85	Yes	No	1	5	5
175	R:R:D293	R:R:N225	6.73	No	Yes	1	4	5
176	R:R:N225	R:R:T294	7.31	Yes	No	0	5	5
177	L:L:R9	R:R:N225	4.82	Yes	Yes	1	0	5
178	R:R:F286	R:R:L228	6.09	Yes	No	1	6	5
179	L:L:R9	R:R:L228	4.86	Yes	No	1	0	5
180	R:R:N229	R:R:Q287	3.96	No	Yes	0	5	8
181	R:R:F291	R:R:N229	3.62	No	No	0	5	5
182	R:R:F233	R:R:L237	3.65	Yes	No	1	8	6
183	R:R:F233	R:R:F279	3.22	Yes	Yes	1	8	9
184	R:R:F233	R:R:L284	4.87	Yes	No	0	8	5
185	R:R:F233	R:R:Q287	12.88	Yes	Yes	1	8	8
186	R:R:F279	R:R:L237	3.65	Yes	No	1	9	6
187	R:R:M245	R:R:T241	4.52	No	No	0	3	4
188	R:R:F242	R:R:Q246	9.37	No	No	4	4	4
189	R:R:T244	R:R:V272	4.76	No	No	0	8	7
190	R:R:L276	R:R:T244	5.9	No	No	0	7	8
191	R:R:L273	R:R:M248	5.65	No	No	0	5	4
192	R:R:L251	R:R:T269	4.42	Yes	No	0	8	6
193	R:R:E265	R:R:N254	5.26	No	No	0	7	5
194	R:R:M256	R:R:Q257	5.44	No	No	0	4	3
195	R:R:F259	R:R:Q257	7.03	No	No	0	1	3
196	R:R:L271	R:R:R267	3.64	No	No	0	8	7
197	R:R:V275	R:R:V331	3.21	No	No	0	8	7
198	R:R:V275	R:R:Y332	6.31	No	Yes	0	8	9
199	R:R:I280	R:R:L276	4.28	No	No	0	6	7
200	R:R:F279	R:R:W283	9.02	Yes	Yes	1	9	9
201	R:R:C282	R:R:N324	9.45	No	No	0	8	9
202	R:R:F286	R:R:W283	5.01	Yes	Yes	1	6	9
203	R:R:Q287	R:R:W283	4.38	Yes	Yes	1	8	9
204	R:R:A321	R:R:W283	7.78	No	Yes	0	8	9
205	R:R:N324	R:R:W283	5.65	No	Yes	0	9	9
206	R:R:M320	R:R:P285	5.03	No	No	0	7	9
207	R:R:F286	R:R:Q287	4.68	Yes	Yes	1	6	8
208	R:R:F286	R:R:S289	3.96	Yes	No	0	6	5
209	R:R:F286	R:R:T290	7.78	Yes	No	1	6	5
210	L:L:F8	R:R:F286	10.72	Yes	Yes	1	0	6
211	L:L:R9	R:R:F286	3.21	Yes	Yes	1	0	6
212	R:R:S289	R:R:T314	6.4	No	No	0	5	5
213	L:L:R9	R:R:T290	10.35	Yes	No	1	0	5
214	R:R:F291	R:R:L295	9.74	No	No	0	5	4
215	R:R:I310	R:R:L292	5.71	No	No	0	5	5
216	R:R:D293	R:R:R297	13.1	No	Yes	1	4	3
217	L:L:R9	R:R:D293	10.72	Yes	No	1	0	4
218	R:R:L295	R:R:L301	4.15	No	No	0	4	1
219	R:R:H296	R:R:R297	11.28	No	Yes	0	3	3
220	R:R:E307	R:R:H296	11.08	No	No	0	3	3
221	L:L:P3	R:R:R297	8.65	No	Yes	1	0	3
222	R:R:D306	R:R:L301	5.43	No	No	0	1	1
223	R:R:D306	R:R:S303	8.83	No	No	0	1	4
224	R:R:C304	R:R:R308	4.18	No	No	5	8	1
225	R:R:D306	R:R:Q305	3.92	No	No	0	1	3
226	R:R:I309	R:R:Q305	4.12	No	No	0	3	3
227	L:L:R1	R:R:D311	13.1	Yes	No	0	0	3
228	L:L:R9	R:R:T314	9.06	Yes	No	0	0	5
229	L:L:R1	R:R:Q315	5.84	Yes	Yes	2	0	4
230	R:R:F319	R:R:S318	6.61	Yes	No	1	5	5
231	L:L:S6	R:R:S318	3.26	No	No	1	0	5
232	L:L:P7	R:R:S318	5.34	Yes	No	1	0	5
233	R:R:F319	R:R:Y322	7.22	Yes	Yes	1	5	7
234	L:L:P7	R:R:F319	4.33	Yes	Yes	1	0	5
235	L:L:P7	R:R:Y322	6.95	Yes	Yes	1	0	7
236	L:L:F8	R:R:Y322	8.25	Yes	Yes	1	0	7
237	R:R:N324	R:R:N328	8.17	No	Yes	0	9	9
238	R:R:N328	R:R:P329	3.26	Yes	No	0	9	9
239	R:R:Q348	R:R:W344	7.67	No	No	0	4	4
240	L:L:F5	L:L:R1	7.48	Yes	Yes	2	0	0
241	L:L:F5	L:L:P2	7.22	Yes	No	2	0	0
242	L:L:P7	L:L:S6	5.34	Yes	No	1	0	0
243	L:L:F8	L:L:P7	8.67	Yes	Yes	1	0	0
244	R:R:M192	R:R:S138	3.07	No	No	0	4	5
245	R:R:I153	R:R:V239	3.07	No	Yes	0	6	6
246	R:R:I247	R:R:V160	3.07	Yes	Yes	0	8	7
247	R:R:I247	R:R:V272	3.07	Yes	No	0	8	7
248	R:R:K161	R:R:S164	3.06	No	No	0	6	4
249	R:R:C89	R:R:E93	3.04	No	Yes	0	5	7
250	R:R:M226	R:R:V222	3.04	No	No	0	4	3
251	R:R:F82	R:R:G97	3.01	Yes	No	0	7	6
252	R:R:M163	R:R:T162	3.01	No	No	0	5	7
253	R:R:M248	R:R:T244	3.01	No	No	0	4	8
254	R:R:L67	R:R:S323	3	No	No	0	7	4
255	R:R:G166	R:R:R169	3	No	Yes	0	4	6
256	R:R:L129	R:R:V133	2.98	No	No	0	5	5
257	R:R:L227	R:R:V231	2.98	No	No	0	4	5
258	R:R:L271	R:R:V335	2.98	No	No	0	8	6
259	R:R:L104	R:R:T72	2.95	No	No	0	7	6
260	R:R:L237	R:R:T241	2.95	No	No	0	6	4
261	R:R:L276	R:R:T241	2.95	No	No	0	7	4
262	R:R:L298	R:R:T294	2.95	No	No	0	1	5
263	R:R:I247	R:R:L251	2.85	Yes	Yes	0	8	8
264	R:R:I288	R:R:L284	2.85	No	No	0	6	5
265	R:R:I288	R:R:L292	2.85	No	No	0	6	5
266	R:R:I300	R:R:L295	2.85	No	No	0	1	4
267	R:R:I300	R:R:L298	2.85	No	No	0	1	1
268	R:R:I136	R:R:N140	2.83	No	No	0	5	8
269	R:R:L186	R:R:M139	2.83	No	No	0	4	6
270	R:R:G126	R:R:W123	2.81	No	Yes	0	8	8
271	R:R:M256	R:R:N254	2.8	No	No	0	4	5
272	R:R:L273	R:R:L277	2.77	No	No	0	5	5
273	R:R:L278	R:R:L327	2.77	No	No	0	6	7
274	R:R:L124	R:R:N119	2.75	No	No	0	1	4
275	R:R:E345	R:R:Q348	2.55	No	No	0	5	4
276	R:R:S178	R:R:Y95	2.54	No	Yes	3	7	7
277	R:R:S138	R:R:Y142	2.54	No	No	0	5	7
278	R:R:V208	R:R:Y201	2.52	No	Yes	0	1	1
279	R:R:F63	R:R:I59	2.51	No	No	0	4	5
280	R:R:F339	R:R:I334	2.51	Yes	No	0	8	6
281	R:R:M248	R:R:R252	2.48	No	No	0	4	3
282	R:R:F125	R:R:L124	2.44	Yes	No	0	7	1
283	R:R:F233	R:R:L234	2.44	Yes	No	0	8	5
284	R:R:T58	R:R:W55	2.43	No	No	0	6	4
285	R:R:L159	R:R:R155	2.43	No	No	0	8	9
286	R:R:Y177	R:R:Y95	1.99	No	Yes	0	5	7
287	R:R:W344	R:R:Y347	1.93	No	No	0	4	5
288	R:R:C47	R:R:P48	1.88	No	No	0	7	7
289	R:R:A317	R:R:P285	1.87	No	No	0	7	9
290	R:R:G170	R:R:V91	1.84	No	Yes	0	6	6
291	R:R:A71	R:R:C326	1.81	No	Yes	0	8	8
292	R:R:A107	R:R:A71	1.79	No	No	0	6	8
293	R:R:P216	R:R:S217	1.78	No	No	0	3	3
294	R:R:G232	R:R:I145	1.76	No	No	0	6	8
295	R:R:A102	R:R:S143	1.71	No	No	0	8	7
296	R:R:A102	R:R:S144	1.71	No	No	0	8	9
297	R:R:A135	R:R:S189	1.71	No	No	0	6	7
298	R:R:C184	R:R:V180	1.71	No	No	0	4	4
299	R:R:C243	R:R:V239	1.71	No	Yes	0	7	6
300	R:R:G54	R:R:N57	1.7	No	Yes	0	6	5
301	R:R:A92	R:R:T90	1.68	No	No	0	7	7
302	R:R:G205	R:R:Q49	1.64	No	No	0	3	2
303	R:R:L235	R:R:P236	1.64	No	No	0	6	9
304	R:R:L284	R:R:P285	1.64	No	No	0	5	9
305	R:R:G349	R:R:Q348	1.64	No	No	0	4	4
306	R:R:S87	R:R:S88	1.63	No	No	0	5	6
307	R:R:S238	R:R:V239	1.62	No	Yes	0	4	6
308	R:R:V346	R:R:V81	1.6	No	Yes	0	5	8
309	R:R:V270	R:R:V274	1.6	No	No	0	6	5
310	R:R:V274	R:R:V331	1.6	No	No	0	5	7
311	R:R:C108	R:R:L104	1.59	No	No	0	5	7
312	R:R:C326	R:R:L327	1.59	Yes	No	0	8	7
313	R:R:A101	R:R:L79	1.58	No	No	0	5	7
314	R:R:A268	R:R:L251	1.58	No	Yes	0	8	8
315	R:R:I313	R:R:S289	1.55	No	No	0	5	5
316	R:R:I136	R:R:V132	1.54	No	No	0	5	4
317	R:R:I219	R:R:V222	1.54	No	No	0	1	3
318	R:R:I262	R:R:T264	1.52	No	No	0	2	4
319	R:R:M226	R:R:T294	1.51	No	No	0	4	5
320	R:R:L70	R:R:V66	1.49	No	No	0	5	5
321	R:R:L73	R:R:V69	1.49	No	No	0	4	4
322	R:R:N207	R:R:S202	1.49	No	No	0	6	2
323	R:R:L271	R:R:V331	1.49	No	No	0	8	7
324	R:R:L129	R:R:T128	1.47	No	No	0	5	2
325	R:R:D203	R:R:S202	1.47	No	No	0	2	2
326	R:R:I334	R:R:L330	1.43	No	No	0	6	6
327	R:R:G183	R:R:W182	1.41	No	Yes	0	4	9
328	R:R:E200	R:R:T209	1.41	No	No	0	2	5
329	R:R:N253	R:R:N254	1.36	No	No	0	4	5
330	R:R:K260	R:R:Q257	1.36	No	No	0	3	3
331	R:R:K260	R:R:Q263	1.36	No	No	0	3	4
332	R:R:P191	R:R:W220	1.35	No	No	0	7	2
333	R:R:E345	R:R:K341	1.35	No	No	0	5	5
334	R:R:E265	R:R:L251	1.33	No	Yes	0	7	8
335	R:R:N253	R:R:Q249	1.32	No	No	0	4	4
336	R:R:F68	R:R:V69	1.31	Yes	No	0	7	4
337	R:R:R266	R:R:T269	1.29	No	No	0	4	6
338	R:R:M168	R:R:R167	1.24	No	No	0	3	3
339	R:R:K337	R:R:R267	1.24	No	No	0	4	7
340	R:R:K337	R:R:R340	1.24	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N57	4.746	5	2	5
2	R:R:L64	6.92	4	1	6
3	R:R:F68	4.306	5	1	7
4	R:R:V81	4.8125	4	6	8
5	R:R:F82	6.2925	4	0	7
6	R:R:V91	3.7975	4	3	6
7	R:R:E93	7.8625	4	0	7
8	R:R:Y95	4.77667	6	3	7
9	R:R:D103	6.28	4	0	9
10	R:R:L110	4.538	5	1	8
11	R:R:F121	7.65	5	2	4
12	R:R:W123	7.34833	6	8	8
13	R:R:F125	7.705	4	0	7
14	R:R:F147	9.2275	4	3	8
15	R:R:Y156	5.71833	6	4	8
16	R:R:V160	5.9675	4	4	7
17	R:R:R169	6.3875	4	3	6
18	R:R:W182	6.29	4	3	9
19	R:R:R196	10.2725	4	1	4
20	R:R:Y201	6.8375	4	0	1
21	R:R:E204	5.185	4	0	2
22	R:R:I213	8.3975	4	1	4
23	R:R:Y215	9.144	5	1	5
24	R:R:E221	5.5725	4	1	4
25	R:R:N225	6.1775	4	1	5
26	R:R:F233	5.412	5	1	8
27	R:R:V239	3.8825	4	0	6
28	R:R:I247	3.1875	4	0	8
29	R:R:L251	2.545	4	0	8
30	R:R:F279	5.19	4	1	9
31	R:R:W283	6.36857	7	1	9
32	R:R:F286	5.92143	7	1	6
33	R:R:Q287	6.475	4	1	8
34	R:R:R297	9.13	4	1	3
35	R:R:Q315	5.8675	4	2	4
36	R:R:F319	7.43333	6	1	5
37	R:R:Y322	6.30167	6	1	7
38	R:R:C326	3.178	5	0	8
39	R:R:N328	5.55	5	0	9
40	R:R:Y332	6.104	5	0	9
41	R:R:F339	5.81	4	6	8
42	L:L:R1	7.04167	6	2	0
43	L:L:F5	8.355	6	2	0
44	L:L:P7	6.45667	6	1	0
45	L:L:F8	9.65	4	1	0
46	L:L:R9	7.17	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L53	R:R:V50	10.8187	10.43	No	No	0	3	4
2	R:R:L53	R:R:V312	12.9689	5.96	No	No	0	3	2
3	R:R:V312	R:R:W52	10.8187	3.68	No	No	0	2	3
4	L:L:R1	R:R:L53	25.6573	4.86	Yes	No	0	0	3
5	L:L:R1	R:R:F121	37.0416	7.48	Yes	Yes	2	0	4
6	R:R:F121	R:R:N57	20.7353	6.04	Yes	Yes	2	4	5
7	R:R:E204	R:R:H206	12.7025	8.62	Yes	No	0	2	2
8	R:R:F121	R:R:I117	92.3294	3.77	Yes	No	0	4	5
9	R:R:F319	R:R:I117	100	3.77	Yes	No	0	5	5
10	R:R:F319	R:R:Y322	47.5401	7.22	Yes	Yes	1	5	7
11	R:R:L110	R:R:Y322	13.5088	4.69	Yes	Yes	1	8	7
12	R:R:F68	R:R:L110	11.1763	3.65	Yes	Yes	1	7	8
13	R:R:L110	R:R:L67	11.1015	4.15	Yes	No	0	8	7
14	R:R:C326	R:R:L67	10.8725	3.17	Yes	No	0	8	7
15	R:R:C326	R:R:E74	11.3305	4.56	Yes	No	0	8	8
16	R:R:E74	R:R:P329	11.6133	6.29	No	No	0	8	9
17	L:L:F8	R:R:Y322	59.0413	8.25	Yes	Yes	1	0	7
18	L:L:F8	R:R:L141	50.2793	10.96	Yes	No	0	0	7
19	R:R:L141	R:R:W283	50.284	5.69	No	Yes	0	7	9
20	R:R:N324	R:R:W283	37.0276	5.65	No	Yes	0	9	9
21	R:R:N324	R:R:N328	35.8216	8.17	No	Yes	0	9	9
22	R:R:D103	R:R:N328	51.0692	8.08	Yes	Yes	0	9	9
23	L:L:P7	R:R:F319	55.9095	4.33	Yes	Yes	1	0	5
24	L:L:F8	L:L:P7	62.8018	8.67	Yes	Yes	1	0	0
25	L:L:F8	R:R:F286	72.2462	10.72	Yes	Yes	1	0	6
26	R:R:F286	R:R:W283	63.8044	5.01	Yes	Yes	1	6	9
27	R:R:F279	R:R:W283	77.5259	9.02	Yes	Yes	1	9	9
28	R:R:F279	R:R:L148	74.1767	4.87	Yes	No	0	9	8
29	R:R:L148	R:R:Y332	87.2368	8.21	No	Yes	0	8	9
30	R:R:L96	R:R:Y332	39.2012	3.52	No	Yes	0	8	9
31	R:R:L96	R:R:V333	38.0045	5.96	No	No	0	8	7
32	R:R:V333	R:R:V78	36.8032	3.21	No	No	0	7	8
33	R:R:F82	R:R:V78	31.9513	5.24	Yes	No	0	7	8
34	R:R:F339	R:R:F82	11.8494	6.43	Yes	Yes	0	8	7
35	R:R:E93	R:R:F82	18.2205	10.49	Yes	Yes	0	7	7
36	R:R:E93	R:R:K342	13.0881	9.45	Yes	No	0	7	5
37	R:R:H85	R:R:K342	11.8611	22.27	No	No	0	5	5
38	R:R:D103	R:R:S144	51.7914	5.89	Yes	No	0	9	9
39	R:R:A102	R:R:S144	50.8706	1.71	No	No	0	8	9
40	R:R:A102	R:R:S143	50.0082	1.71	No	No	0	8	7
41	R:R:S143	R:R:W182	57.2534	4.94	No	Yes	0	7	9
42	R:R:N98	R:R:W182	26.2229	6.78	No	Yes	3	9	9
43	R:R:N98	R:R:S178	25.0146	8.94	No	No	3	9	7
44	R:R:S178	R:R:Y95	47.65	2.54	No	Yes	3	7	7
45	R:R:V91	R:R:Y95	12.5879	5.05	Yes	Yes	3	6	7
46	L:L:P7	R:R:W113	31.4792	8.11	Yes	No	0	0	6
47	R:R:N134	R:R:W113	19.2956	7.91	No	No	0	5	6
48	R:R:N134	R:R:R196	18.6272	24.1	No	Yes	0	5	4
49	R:R:M192	R:R:R196	13.4387	3.72	No	Yes	1	4	4
50	R:R:M192	R:R:S138	16.5424	3.07	No	No	0	4	5
51	R:R:S138	R:R:S189	15.1985	4.89	No	No	0	5	7
52	R:R:M139	R:R:S189	15.0373	4.6	No	No	0	6	7
53	R:R:M139	R:R:T185	15.2242	4.52	No	No	0	6	8
54	R:R:S143	R:R:T185	15.4463	9.59	No	No	0	7	8
55	R:R:F147	R:R:W182	28.733	12.03	Yes	Yes	3	8	9
56	R:R:F147	R:R:S178	25.1081	3.96	Yes	No	3	8	7
57	R:R:D154	R:R:Y95	10.0521	8.05	No	Yes	3	8	7
58	R:R:A174	R:R:Y95	10.2251	4	No	Yes	0	7	7
59	R:R:T116	R:R:W113	18.55	6.06	No	No	0	5	6
60	R:R:T116	R:R:W123	17.5591	4.85	No	Yes	0	5	8
61	L:L:F5	R:R:Y201	12.7866	13.41	Yes	Yes	0	0	1
62	R:R:R155	R:R:Y332	43.2491	6.17	No	Yes	0	9	9
63	R:R:I247	R:R:R155	41.0288	3.76	Yes	No	0	8	9
64	R:R:I247	R:R:V160	22.0488	3.07	Yes	Yes	0	8	7
65	R:R:V160	R:R:Y156	16.921	10.09	Yes	Yes	4	7	8
66	R:R:Y177	R:R:Y95	10.2251	1.99	No	Yes	0	5	7
67	R:R:G205	R:R:H206	12.5856	3.18	No	No	0	3	2
68	L:L:R9	R:R:F286	17.6689	3.21	Yes	Yes	1	0	6
69	L:L:R9	R:R:D293	11.5245	10.72	Yes	No	1	0	4
70	R:R:D293	R:R:R297	12.5973	13.1	No	Yes	1	4	3
71	R:R:N225	R:R:T294	10.3583	7.31	Yes	No	0	5	5
72	R:R:F286	R:R:Q287	14.2076	4.68	Yes	Yes	1	6	8
73	R:R:F233	R:R:Q287	12.3145	12.88	Yes	Yes	1	8	8
74	R:R:F279	R:R:L237	12.034	3.65	Yes	No	1	9	6
75	R:R:L237	R:R:T241	16.2269	2.95	No	No	0	6	4
76	R:R:L276	R:R:T241	13.0156	2.95	No	No	0	7	4
77	R:R:I247	R:R:L251	16.8626	2.85	Yes	Yes	0	8	8
78	R:R:E265	R:R:L251	11.7793	1.33	No	Yes	0	7	8
79	R:R:E265	R:R:N254	10.4775	5.26	No	No	0	7	5
80	R:R:V275	R:R:Y332	11.7863	6.31	No	Yes	0	8	9
81	R:R:V275	R:R:V331	10.4938	3.21	No	No	0	8	7
82	L:L:F5	R:R:F121	26.9054	13.93	Yes	Yes	2	0	4
83	R:R:L148	R:R:N328	20.6698	4.12	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L53	R:R:V50	10.43	0	No	No	3	4	1	2
R:R:L53	R:R:V312	5.96	0	No	No	3	2	1	2
L:L:R1	R:R:L53	4.86	2	Yes	No	0	3	0	1
R:R:L56	R:R:Q315	5.32	0	No	Yes	3	4	2	1
R:R:F121	R:R:N57	6.04	2	Yes	Yes	4	5	1	2
R:R:E204	R:R:N57	5.26	0	Yes	Yes	2	5	1	2
R:R:N57	R:R:Q315	5.28	2	Yes	Yes	5	4	2	1
R:R:L64	R:R:Q60	6.65	1	Yes	No	6	5	2	2
R:R:F319	R:R:Q60	11.71	1	Yes	No	5	5	1	2
R:R:L110	R:R:L64	6.92	1	Yes	Yes	8	6	2	2
R:R:F319	R:R:L64	10.96	1	Yes	Yes	5	6	1	2
R:R:L106	R:R:Y322	5.86	0	No	Yes	7	7	2	1
R:R:L110	R:R:Y322	4.69	1	Yes	Yes	8	7	2	1
R:R:T116	R:R:W113	6.06	0	No	No	5	6	2	1
R:R:N134	R:R:W113	7.91	0	No	No	5	6	2	1
L:L:P7	R:R:W113	8.11	1	Yes	No	0	6	0	1
R:R:F121	R:R:I117	3.77	2	Yes	No	4	5	1	2
R:R:F319	R:R:I117	3.77	1	Yes	No	5	5	1	2
R:R:F121	R:R:Q315	7.03	2	Yes	Yes	4	4	1	1
L:L:R1	R:R:F121	7.48	2	Yes	Yes	0	4	0	1
L:L:F5	R:R:F121	13.93	2	Yes	Yes	0	4	0	1
R:R:N134	R:R:R196	24.1	0	No	Yes	5	4	2	1
R:R:I137	R:R:Y322	4.84	0	No	Yes	6	7	2	1
R:R:L141	R:R:W283	5.69	0	No	Yes	7	9	1	2
L:L:F8	R:R:L141	10.96	1	Yes	No	0	7	0	1
R:R:M192	R:R:R196	3.72	1	No	Yes	4	4	2	1
R:R:I213	R:R:M192	4.37	1	Yes	No	4	4	1	2
R:R:I213	R:R:R196	8.77	1	Yes	Yes	4	4	1	1
L:L:G4	R:R:R196	4.5	1	No	Yes	0	4	0	1
R:R:K199	R:R:V212	4.55	2	No	No	4	4	2	1
R:R:D203	R:R:Y201	8.05	0	No	Yes	2	1	2	1
R:R:E204	R:R:Y201	3.37	0	Yes	Yes	2	1	1	1
L:L:F5	R:R:Y201	13.41	2	Yes	Yes	0	1	0	1
R:R:E204	R:R:H206	8.62	0	Yes	No	2	2	1	2
L:L:R1	R:R:E204	3.49	2	Yes	Yes	0	2	0	1
L:L:F5	R:R:A210	4.16	2	Yes	No	0	2	0	1
L:L:P2	R:R:V212	3.53	2	No	No	0	4	0	1
L:L:F5	R:R:V212	3.93	2	Yes	No	0	4	0	1
R:R:I213	R:R:Y215	16.92	1	Yes	Yes	4	5	1	1
L:L:G4	R:R:I213	3.53	1	No	Yes	0	4	0	1
R:R:W220	R:R:Y215	5.79	0	No	Yes	2	5	2	1
R:R:E221	R:R:Y215	10.1	1	Yes	Yes	4	5	1	1
R:R:T224	R:R:Y215	8.74	0	No	Yes	5	5	2	1
L:L:P3	R:R:Y215	4.17	1	No	Yes	0	5	0	1
R:R:E221	R:R:L218	3.98	1	Yes	No	4	2	1	2
R:R:E221	R:R:R297	3.49	1	Yes	Yes	4	3	1	1
L:L:P3	R:R:E221	4.72	1	No	Yes	0	4	0	1
R:R:N225	R:R:T290	5.85	1	Yes	No	5	5	1	1
R:R:D293	R:R:N225	6.73	1	No	Yes	4	5	1	1
R:R:N225	R:R:T294	7.31	1	Yes	No	5	5	1	2
L:L:R9	R:R:N225	4.82	1	Yes	Yes	0	5	0	1
R:R:F286	R:R:L228	6.09	1	Yes	No	6	5	1	1
L:L:R9	R:R:L228	4.86	1	Yes	No	0	5	0	1
R:R:F286	R:R:W283	5.01	1	Yes	Yes	6	9	1	2
R:R:Q287	R:R:W283	4.38	1	Yes	Yes	8	9	2	2
R:R:F286	R:R:Q287	4.68	1	Yes	Yes	6	8	1	2
R:R:F286	R:R:S289	3.96	1	Yes	No	6	5	1	2
R:R:F286	R:R:T290	7.78	1	Yes	No	6	5	1	1
L:L:F8	R:R:F286	10.72	1	Yes	Yes	0	6	0	1
L:L:R9	R:R:F286	3.21	1	Yes	Yes	0	6	0	1
R:R:S289	R:R:T314	6.4	0	No	No	5	5	2	1
L:L:R9	R:R:T290	10.35	1	Yes	No	0	5	0	1
R:R:D293	R:R:R297	13.1	1	No	Yes	4	3	1	1
L:L:R9	R:R:D293	10.72	1	Yes	No	0	4	0	1
R:R:H296	R:R:R297	11.28	0	No	Yes	3	3	2	1
L:L:P3	R:R:R297	8.65	1	No	Yes	0	3	0	1
L:L:R1	R:R:D311	13.1	2	Yes	No	0	3	0	1
L:L:R9	R:R:T314	9.06	1	Yes	No	0	5	0	1
L:L:R1	R:R:Q315	5.84	2	Yes	Yes	0	4	0	1
R:R:F319	R:R:S318	6.61	1	Yes	No	5	5	1	1
L:L:S6	R:R:S318	3.26	1	No	No	0	5	0	1
L:L:P7	R:R:S318	5.34	1	Yes	No	0	5	0	1
R:R:F319	R:R:Y322	7.22	1	Yes	Yes	5	7	1	1
L:L:P7	R:R:F319	4.33	1	Yes	Yes	0	5	0	1
L:L:P7	R:R:Y322	6.95	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:Y322	8.25	1	Yes	Yes	0	7	0	1
R:R:V208	R:R:Y201	2.52	0	No	Yes	1	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F6H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	298
Number of Links	340
Number of Hubs	46
Number of Links mediated by Hubs	173
Number of Communities	9
Number of Nodes involved in Communities	67
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	97240
Length Of Smallest Path	3
Average Path Length	14.7325
Length of Longest Path	28
Minimum Path Strength	1.24
Average Path Strength	6.10047
Maximum Path Strength	17.29
Minimum Path Correlation	0.7
Average Path Correlation	0.930164
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.725
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0148
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • hydrolase activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • catalytic activity • phospholipase activity • lipase activity • protein binding • binding • enzyme binding • protease binding • protein heterodimerization activity • protein dimerization activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • bradykinin receptor activity • angiotensin receptor binding • signaling receptor binding • type 1 angiotensin receptor binding • G protein-coupled receptor binding • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization
Gene Ontology	Biological Process	• organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • smooth muscle contraction • muscle contraction • muscle system process • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • cellular response to stimulus • regulation of cellular process • response to stimulus • intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • negative regulation of biological process • regulation of cellular response to stress • regulation of signal transduction • regulation of programmed cell death • intracellular signal transduction • cellular response to environmental stimulus • cell communication • regulation of response to osmotic stress • regulation of cellular response to osmotic stress • negative regulation of apoptotic signaling pathway • signal transduction • intrinsic apoptotic signaling pathway • negative regulation of signal transduction by p53 class mediator • regulation of biological process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • cell death • negative regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to osmotic stress • regulation of response to stimulus • response to chemical • response to abiotic stimulus • intrinsic apoptotic signaling pathway by p53 class mediator • cellular response to abiotic stimulus • regulation of apoptotic signaling pathway • signaling • negative regulation of signaling • negative regulation of intracellular signal transduction • cellular response to chemical stress • regulation of intrinsic apoptotic signaling pathway • negative regulation of cell communication • cellular response to stress • regulation of intracellular signal transduction • response to stress • regulation of response to stress • regulation of signal transduction by p53 class mediator • negative regulation of cellular process • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to osmotic stress • regulation of signaling • negative regulation of response to stimulus • signal transduction by p53 class mediator • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • cellular response to osmotic stress • negative regulation of signal transduction • apoptotic signaling pathway • negative regulation of intrinsic apoptotic signaling pathway • cellular response to chemical stimulus • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • regulation of cell communication • cellular process • apoptotic process • regulation of intrinsic apoptotic signaling pathway by p53 class mediator • programmed cell death • regulation of vascular permeability • regulation of system process • regulation of blood circulation • regulation of vasoconstriction • regulation of multicellular organismal process • vasodilation • cell surface receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • defense response • inflammatory response • G protein-coupled receptor signaling pathway • response to salt stress • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm • vesicle • protein binding • binding • signaling receptor binding • enzyme regulator activity • molecular function inhibitor activity • peptidase regulator activity • molecular function regulator activity • enzyme inhibitor activity • cysteine-type endopeptidase inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • hormone activity • molecular function activator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • metal ion binding • small molecule binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • multicellular organismal process • regulation of body fluid levels • wound healing • response to stimulus • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • positive regulation of cytosolic calcium ion concentration • regulation of biological process • positive regulation of programmed cell death • regulation of cellular process • regulation of apoptotic process • positive regulation of biological process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cellular process • apoptotic process • programmed cell death • positive regulation of cellular process • regulation of response to external stimulus • negative regulation of biological process • regulation of response to wounding • regulation of coagulation • regulation of response to stress • regulation of multicellular organismal process • regulation of hemostasis • negative regulation of response to stimulus • negative regulation of wound healing • regulation of blood coagulation • negative regulation of blood coagulation • response to external stimulus • negative regulation of response to wounding • negative regulation of hemostasis • negative regulation of coagulation • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of wound healing • negative regulation of multicellular organismal process • negative regulation of proteolysis • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • regulation of proteolysis • proteolysis • negative regulation of cellular process • metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • defense response • inflammatory response • cell adhesion • regulation of cell adhesion • negative regulation of cell adhesion • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • blood microparticle • membrane-enclosed lumen • intracellular organelle lumen • endoplasmic reticulum lumen • organelle lumen • endoplasmic reticulum • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen • secretory granule • secretory vesicle • platelet alpha granule • platelet alpha granule lumen • GTPase regulator activity • enzyme activator activity • GTPase activator activity • nucleoside-triphosphatase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • ribonucleotide binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • G protein-coupled receptor binding • cellular response to stimulus • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • cell communication • regulation of cell communication • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • nuclear membrane • nucleus • organelle envelope • nuclear envelope • organelle membrane • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30411
Sequence	>7F6H_nogp_Chain_R C P Q V E W L G W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H K S S C T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N F D W L F G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K T M S M G R M R G V R W A K L Y S L V I W G C T L L L S S P M L V F R T M K E Y S D E G H N V T A C V I S Y P S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K F K E I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G I L S S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R F R K K S W E V Y Q G V C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F6H	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-	Gq/β1/γ2	2.9	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6H (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-		2.9	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6I	A	Peptide	Bradykinin	BK₂	Homo sapiens	Kallidin	-	Gq/β1/γ2	2.8	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F6I (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Kallidin	-		2.8	2022-01-05	doi.org/10.1038/s41467-022-28399-1
	7F2O	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-10-13	doi.org/10.1038/s41594-021-00645-y
	7F2O (No Gprot)	A	Peptide	Bradykinin	BK₂	Homo sapiens	Bradykinin	-		2.9	2021-10-13	doi.org/10.1038/s41594-021-00645-y

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