psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I11	R:R:V169	4.61	No	No	0	3	5
2	R:R:I14	R:R:K12	5.82	No	No	7	3	4
3	R:R:F170	R:R:K12	6.2	No	No	7	3	4
4	R:R:F171	R:R:R13	8.55	No	No	0	6	4
5	R:R:E173	R:R:R13	4.65	No	No	0	3	4
6	R:R:F170	R:R:I14	10.05	No	No	7	3	3
7	R:R:H183	R:R:I14	13.26	Yes	No	7	3	3
8	R:R:E173	R:R:Q15	7.65	No	No	8	3	4
9	R:R:N174	R:R:Q15	3.96	No	No	8	3	4
10	R:R:D16	R:R:P19	6.44	No	Yes	0	4	4
11	L:L:V3	R:R:D16	5.84	No	No	0	0	4
12	L:L:?1	R:R:D17	4.21	No	No	0	0	6
13	R:R:C18	R:R:C274	7.28	No	No	0	8	7
14	R:R:A21	R:R:D281	4.63	No	No	0	4	4
15	R:R:R23	R:R:Y92	7.2	No	Yes	3	4	4
16	L:L:I5	R:R:R23	3.76	Yes	No	3	0	4
17	R:R:H24	R:R:Y26	10.89	Yes	No	5	4	6
18	R:R:H24	R:R:I27	5.3	Yes	No	5	4	3
19	R:R:D278	R:R:H24	7.56	No	Yes	5	4	4
20	R:R:H24	R:R:T282	5.48	Yes	No	5	4	1
21	R:R:I27	R:R:Y26	7.25	No	No	5	3	6
22	R:R:E91	R:R:F28	16.32	No	No	0	3	4
23	R:R:F28	R:R:Y92	4.13	No	Yes	0	4	4
24	R:R:I31	R:R:P32	3.39	Yes	No	0	6	5
25	R:R:I31	R:R:Y35	6.04	Yes	Yes	0	6	7
26	R:R:I31	R:R:P285	5.08	Yes	No	0	6	5
27	R:R:A89	R:R:P32	3.74	No	No	0	3	5
28	R:R:C289	R:R:L34	6.35	No	No	0	5	5
29	R:R:L81	R:R:Y35	8.21	Yes	Yes	0	8	7
30	R:R:I288	R:R:Y35	6.04	No	Yes	0	6	7
31	R:R:C289	R:R:Y35	4.03	No	Yes	0	5	7
32	R:R:F39	R:R:I43	5.02	No	No	0	6	6
33	R:R:F39	R:R:L81	3.65	No	Yes	0	6	8
34	R:R:F39	R:R:P82	14.45	No	No	0	6	9
35	R:R:D74	R:R:N46	6.73	Yes	No	0	9	9
36	R:R:N46	R:R:P299	11.4	No	No	0	9	9
37	R:R:F304	R:R:L48	3.65	No	No	0	6	6
38	R:R:F313	R:R:L48	6.09	No	No	0	7	6
39	R:R:P299	R:R:V49	3.53	No	Yes	0	9	9
40	R:R:F55	R:R:I51	3.77	No	No	0	4	3
41	R:R:F309	R:R:V52	3.93	Yes	No	4	8	7
42	R:R:V52	R:R:Y312	3.79	No	Yes	4	7	5
43	R:R:I53	R:R:L68	4.28	No	No	0	7	5
44	R:R:F55	R:R:Y54	7.22	No	No	0	4	4
45	R:R:Y312	R:R:Y56	10.92	Yes	Yes	4	5	4
46	R:R:Q315	R:R:Y56	7.89	No	Yes	4	3	4
47	R:R:L316	R:R:Y56	8.21	No	Yes	0	4	4
48	R:R:Y319	R:R:Y56	3.97	No	Yes	0	5	4
49	R:R:M57	R:R:S64	7.67	No	No	0	5	8
50	R:R:K58	R:R:K60	5.75	No	No	0	5	7
51	R:R:L59	R:R:L68	5.54	No	No	0	7	5
52	R:R:S64	R:R:T61	4.8	No	No	0	8	8
53	R:R:A145	R:R:V65	5.09	No	Yes	0	7	6
54	R:R:K146	R:R:V65	4.55	No	Yes	0	3	6
55	R:R:C121	R:R:F66	4.19	No	Yes	0	7	7
56	R:R:F66	R:R:L122	3.65	Yes	No	0	7	9
57	R:R:D125	R:R:F66	9.55	No	Yes	0	8	7
58	R:R:F66	R:R:T148	5.19	Yes	No	0	7	5
59	R:R:L118	R:R:N69	4.12	No	No	0	7	9
60	R:R:C149	R:R:N69	7.87	No	No	0	7	9
61	R:R:N69	R:R:W153	6.78	No	Yes	0	9	9
62	R:R:D74	R:R:L70	4.07	Yes	Yes	6	9	9
63	R:R:L119	R:R:L70	5.54	No	Yes	6	8	9
64	R:R:L70	R:R:N298	4.12	Yes	No	6	9	9
65	R:R:L70	R:R:Y302	3.52	Yes	Yes	6	9	9
66	R:R:D74	R:R:S115	5.89	Yes	No	0	9	9
67	R:R:A295	R:R:D74	4.63	No	Yes	0	9	9
68	R:R:D74	R:R:N298	6.73	Yes	No	6	9	9
69	R:R:C76	R:R:N111	6.3	No	No	0	7	8
70	R:R:L83	R:R:T80	4.42	No	No	0	6	7
71	R:R:T80	R:R:W84	4.85	No	Yes	0	7	7
72	R:R:S107	R:R:T80	6.4	No	No	0	5	7
73	R:R:L81	R:R:Y292	8.21	Yes	No	0	8	7
74	R:R:F96	R:R:L83	4.87	Yes	No	0	6	6
75	R:R:W84	R:R:Y87	3.86	Yes	Yes	0	7	5
76	R:R:A104	R:R:W84	3.89	No	Yes	0	6	7
77	L:L:P7	R:R:W84	16.21	No	Yes	0	0	7
78	R:R:Y87	R:R:Y92	10.92	Yes	Yes	3	5	4
79	R:R:W94	R:R:Y87	10.61	Yes	Yes	3	9	5
80	L:L:I5	R:R:Y87	4.84	Yes	Yes	3	0	5
81	R:R:T88	R:R:Y92	7.49	No	Yes	0	5	4
82	R:R:M90	R:R:P95	3.35	No	No	0	5	3
83	R:R:E91	R:R:R93	10.47	No	No	0	3	5
84	L:L:I5	R:R:Y92	8.46	Yes	Yes	3	0	4
85	R:R:I177	R:R:R93	5.01	No	No	0	1	5
86	R:R:F96	R:R:W94	17.04	Yes	Yes	0	6	9
87	R:R:C101	R:R:W94	9.14	No	Yes	3	9	9
88	R:R:C180	R:R:W94	15.67	No	Yes	3	9	9
89	R:R:F96	R:R:P95	7.22	Yes	No	0	6	3
90	R:R:F96	R:R:L100	6.09	Yes	No	0	6	5
91	R:R:K102	R:R:N98	8.39	No	No	0	6	3
92	R:R:N168	R:R:N98	6.81	No	No	0	3	3
93	R:R:N98	R:R:V169	5.91	No	No	0	3	5
94	R:R:C101	R:R:C180	7.28	No	No	3	9	9
95	R:R:R167	R:R:S105	15.81	No	No	0	5	5
96	R:R:A106	R:R:I164	4.87	No	No	0	5	5
97	R:R:V108	R:R:Y292	3.79	No	No	0	6	7
98	L:L:F8	R:R:V108	3.93	Yes	No	0	0	6
99	R:R:S109	R:R:S160	6.52	No	No	0	4	7
100	R:R:A163	R:R:S109	3.42	No	No	0	4	4
101	L:L:F8	R:R:S109	5.28	Yes	No	0	0	4
102	R:R:F110	R:R:N111	4.83	Yes	No	0	5	8
103	R:R:F110	R:R:W153	7.02	Yes	Yes	0	5	9
104	R:R:L112	R:R:W253	3.42	No	Yes	0	7	8
105	R:R:L112	R:R:Y292	7.03	No	No	0	7	7
106	L:L:F8	R:R:L112	4.87	Yes	No	0	0	7
107	R:R:F117	R:R:Y113	6.19	No	Yes	0	5	7
108	R:R:A159	R:R:Y113	8.01	No	Yes	0	5	7
109	R:R:T198	R:R:Y113	4.99	No	Yes	0	3	7
110	R:R:K199	R:R:Y113	4.78	Yes	Yes	2	5	7
111	L:L:F8	R:R:Y113	4.13	Yes	Yes	2	0	7
112	R:R:A114	R:R:W153	6.48	No	Yes	0	7	9
113	R:R:P207	R:R:V116	3.53	Yes	No	0	8	8
114	R:R:V116	R:R:W253	4.9	No	Yes	0	8	8
115	R:R:F117	R:R:L155	3.65	No	No	0	5	4
116	R:R:L119	R:R:Y302	5.86	No	Yes	6	8	9
117	R:R:P207	R:R:T120	3.5	Yes	No	0	8	7
118	R:R:I210	R:R:T120	6.08	No	No	0	7	7
119	R:R:I211	R:R:S123	4.64	No	No	0	8	9
120	R:R:S123	R:R:S214	4.89	No	No	0	9	7
121	R:R:S123	R:R:Y215	5.09	No	Yes	0	9	9
122	R:R:D125	R:R:R140	10.72	No	Yes	0	8	6
123	R:R:R126	R:R:Y215	8.23	No	Yes	0	9	9
124	R:R:R126	R:R:Y302	7.2	No	Yes	0	9	9
125	R:R:L128	R:R:Y127	3.52	No	Yes	0	5	8
126	R:R:V131	R:R:Y127	11.36	No	Yes	1	7	8
127	R:R:H132	R:R:Y127	8.71	No	Yes	1	6	8
128	R:R:L217	R:R:Y127	8.21	No	Yes	0	3	8
129	R:R:I218	R:R:Y127	3.63	No	Yes	1	8	8
130	R:R:L128	R:R:R140	3.64	No	Yes	0	5	6
131	R:R:A129	R:R:R140	5.53	No	Yes	0	8	6
132	R:R:I130	R:R:I218	4.42	No	No	1	8	8
133	R:R:H132	R:R:V131	11.07	No	No	1	6	7
134	R:R:A221	R:R:V131	5.09	No	No	0	5	7
135	R:R:R140	R:R:S136	6.59	Yes	No	0	6	6
136	R:R:H166	R:R:P192	4.58	No	No	0	4	3
137	R:R:F182	R:R:R167	17.1	Yes	No	0	4	5
138	R:R:C180	R:R:V169	5.12	No	No	0	9	5
139	R:R:F170	R:R:H183	3.39	No	Yes	7	3	3
140	R:R:F171	R:R:N176	3.62	No	No	0	6	5
141	R:R:E173	R:R:N174	3.94	No	No	8	3	3
142	R:R:I177	R:R:T175	9.12	No	No	0	1	2
143	H:H:?401	R:R:N176	30.8	No	No	0	0	5
144	R:R:F182	R:R:Y184	4.13	Yes	Yes	2	4	4
145	R:R:F182	R:R:L195	4.87	Yes	No	0	4	5
146	L:L:Y4	R:R:F182	6.19	Yes	Yes	2	0	4
147	R:R:E185	R:R:H183	4.92	No	Yes	0	5	3
148	L:L:?1	R:R:H183	14.62	No	Yes	0	0	3
149	R:R:P192	R:R:Y184	4.17	No	Yes	0	3	4
150	R:R:Q267	R:R:Y184	12.4	No	Yes	0	3	4
151	L:L:R2	R:R:Y184	5.14	Yes	Yes	0	0	4
152	L:L:Y4	R:R:Y184	6.95	Yes	Yes	2	0	4
153	R:R:E185	R:R:S189	4.31	No	No	0	5	2
154	R:R:N188	R:R:Q187	13.2	No	No	0	3	1
155	R:R:P192	R:R:S189	8.91	No	No	0	3	2
156	R:R:Q267	R:R:S189	5.78	No	No	0	3	2
157	R:R:I193	R:R:Q267	6.86	No	No	0	2	3
158	R:R:H256	R:R:K199	7.86	Yes	Yes	2	6	5
159	R:R:K199	R:R:T260	10.51	Yes	No	2	5	6
160	L:L:F8	R:R:K199	23.58	Yes	Yes	2	0	5
161	R:R:N200	R:R:Q257	3.96	No	No	0	4	8
162	R:R:F261	R:R:N200	3.62	No	No	0	5	4
163	R:R:G203	R:R:P207	4.06	No	Yes	0	5	8
164	R:R:F204	R:R:F250	6.43	Yes	Yes	9	8	5
165	R:R:F204	R:R:I254	3.77	Yes	Yes	9	8	5
166	R:R:F204	R:R:Q257	10.54	Yes	No	0	8	8
167	R:R:F208	R:R:L212	6.09	No	No	0	6	5
168	R:R:F208	R:R:F250	9.65	No	Yes	0	6	5
169	R:R:F249	R:R:I211	5.02	No	No	0	9	8
170	R:R:I242	R:R:Y215	3.63	No	Yes	0	7	9
171	R:R:I245	R:R:Y215	4.84	No	Yes	0	8	9
172	R:R:V246	R:R:Y215	5.05	No	Yes	0	8	9
173	R:R:K223	R:R:W219	3.48	No	Yes	1	5	5
174	R:R:F239	R:R:W219	10.02	Yes	Yes	1	6	5
175	R:R:I242	R:R:W219	5.87	No	Yes	0	7	5
176	R:R:M243	R:R:W219	4.65	No	Yes	0	4	5
177	R:R:F239	R:R:L222	4.87	Yes	No	1	6	8
178	R:R:F239	R:R:K223	8.69	Yes	No	1	6	5
179	R:R:P233	R:R:Y226	5.56	No	Yes	1	3	4
180	R:R:N235	R:R:Y226	6.98	No	Yes	1	6	4
181	R:R:I238	R:R:Y226	4.84	No	Yes	0	7	4
182	R:R:K232	R:R:R234	3.71	No	No	0	3	5
183	R:R:N235	R:R:P233	6.52	No	No	1	6	3
184	R:R:F239	R:R:N235	6.04	Yes	No	1	6	6
185	R:R:D236	R:R:D237	10.65	No	No	0	4	7
186	R:R:F239	R:R:I238	3.77	Yes	No	0	6	7
187	R:R:I241	R:R:L305	4.28	No	No	0	8	7
188	R:R:I245	R:R:Y302	8.46	No	Yes	0	8	9
189	R:R:F248	R:R:S252	3.96	Yes	No	10	6	8
190	R:R:F248	R:R:N294	6.04	Yes	No	10	6	9
191	R:R:F248	R:R:L297	7.31	Yes	No	0	6	6
192	R:R:F248	R:R:F301	11.79	Yes	No	0	6	8
193	R:R:F249	R:R:W253	5.01	No	Yes	0	9	8
194	R:R:F250	R:R:F251	10.72	Yes	No	0	5	6
195	R:R:F250	R:R:I254	7.54	Yes	Yes	9	5	5
196	R:R:N294	R:R:S252	8.94	No	No	10	9	8
197	R:R:N294	R:R:W253	7.91	No	Yes	0	9	8
198	R:R:I254	R:R:P255	5.08	Yes	No	0	5	9
199	R:R:I254	R:R:I258	4.42	Yes	No	0	5	6
200	R:R:P255	R:R:T287	3.5	No	No	0	9	7
201	R:R:I290	R:R:P255	5.08	No	No	0	8	9
202	R:R:H256	R:R:T260	6.85	Yes	No	2	6	6
203	R:R:H256	R:R:M284	3.94	Yes	No	2	6	4
204	R:R:H256	R:R:T287	8.21	Yes	No	0	6	7
205	R:R:H256	R:R:I288	3.98	Yes	No	0	6	6
206	L:L:F8	R:R:H256	7.92	Yes	Yes	2	0	6
207	R:R:A283	R:R:F259	8.32	No	No	0	5	5
208	R:R:F261	R:R:L265	6.09	No	No	0	5	3
209	L:L:R2	R:R:D263	7.15	Yes	No	0	0	4
210	L:L:Y4	R:R:D263	6.9	Yes	No	0	0	4
211	R:R:I270	R:R:L265	5.71	No	No	0	2	3
212	R:R:I271	R:R:L265	4.28	No	No	0	1	3
213	R:R:I266	R:R:I271	5.89	No	No	0	2	1
214	R:R:I266	R:R:V280	4.61	No	No	0	2	4
215	L:L:R2	R:R:I266	5.01	Yes	No	0	0	2
216	R:R:I271	R:R:I276	4.42	No	No	0	1	1
217	R:R:D273	R:R:R275	4.76	No	No	0	4	2
218	R:R:A277	R:R:C274	3.61	No	No	0	3	7
219	R:R:I276	R:R:I279	4.42	No	No	0	1	1
220	R:R:D278	R:R:T282	4.34	No	No	5	4	1
221	L:L:R2	R:R:D281	10.72	Yes	No	0	0	4
222	L:L:H6	R:R:D281	11.35	Yes	No	0	0	4
223	L:L:Y4	R:R:M284	4.79	Yes	No	2	0	4
224	L:L:H6	R:R:M284	9.19	Yes	No	2	0	4
225	L:L:H6	R:R:P285	7.63	Yes	No	0	0	5
226	L:L:P7	R:R:I288	5.08	No	No	0	0	6
227	R:R:F293	R:R:I290	5.02	No	No	0	5	8
228	R:R:N298	R:R:Y302	3.49	No	Yes	6	9	9
229	R:R:F304	R:R:F309	5.36	No	Yes	0	6	8
230	R:R:K308	R:R:Y312	9.55	No	Yes	0	6	5
231	R:R:F309	R:R:Y312	4.13	Yes	Yes	4	8	5
232	R:R:R311	R:R:Y312	11.32	No	Yes	4	5	5
233	R:R:Q315	R:R:R311	8.18	No	No	4	3	5
234	R:R:Q315	R:R:Y312	4.51	No	Yes	4	3	5
235	L:L:?1	L:L:V3	4.62	No	No	0	0	0
236	L:L:H6	L:L:Y4	11.98	Yes	Yes	2	0	0
237	R:R:L161	R:R:P162	3.28	No	No	0	4	6
238	R:R:C121	R:R:I152	3.27	No	No	0	7	7
239	R:R:N174	R:R:P19	3.26	No	Yes	0	3	4
240	L:L:I5	R:R:A181	3.25	Yes	No	0	0	5
241	R:R:T141	R:R:V144	3.17	No	No	0	7	4
242	R:R:F55	R:R:Y56	3.09	No	Yes	0	4	4
243	R:R:I53	R:R:V49	3.07	No	Yes	0	7	9
244	R:R:I151	R:R:V147	3.07	No	No	0	3	3
245	R:R:I172	R:R:V179	3.07	No	No	0	5	3
246	L:L:I5	R:R:V179	3.07	Yes	No	0	0	3
247	R:R:F110	R:R:G157	3.01	Yes	No	0	5	3
248	R:R:F309	R:R:G303	3.01	Yes	No	0	8	7
249	R:R:L59	R:R:S64	3	No	No	0	7	8
250	R:R:L262	R:R:V280	2.98	No	No	0	5	4
251	R:R:L202	R:R:T198	2.95	No	No	0	4	3
252	R:R:L212	R:R:T216	2.95	No	No	0	5	3
253	R:R:I27	R:R:I31	2.94	No	Yes	0	3	6
254	R:R:I286	R:R:I31	2.94	No	Yes	0	6	6
255	R:R:I124	R:R:I210	2.94	No	No	0	6	7
256	R:R:I164	R:R:I165	2.94	No	No	0	5	4
257	R:R:I241	R:R:I245	2.94	No	No	0	8	8
258	R:R:I31	R:R:M30	2.92	Yes	No	0	6	4
259	R:R:E185	R:R:S186	2.87	No	No	0	5	3
260	R:R:I38	R:R:L81	2.85	No	Yes	0	7	8
261	R:R:I43	R:R:L75	2.85	No	No	0	6	7
262	R:R:I152	R:R:L118	2.85	No	No	0	7	7
263	R:R:I130	R:R:L222	2.85	No	No	1	8	8
264	R:R:I218	R:R:L222	2.85	No	No	1	8	8
265	R:R:L247	R:R:M243	2.83	No	No	0	5	4
266	R:R:G97	R:R:W94	2.81	No	Yes	0	8	9
267	R:R:L122	R:R:L67	2.77	No	No	0	9	8
268	R:R:L68	R:R:L72	2.77	No	No	0	5	5
269	R:R:A156	R:R:F110	2.77	No	Yes	0	8	5
270	R:R:A156	R:R:F117	2.77	No	No	0	8	5
271	R:R:D236	R:R:K240	2.77	No	No	0	4	5
272	R:R:A244	R:R:F301	2.77	No	No	0	5	8
273	R:R:L300	R:R:L305	2.77	No	No	0	6	7
274	R:R:A85	R:R:Y35	2.67	No	Yes	0	7	7
275	R:R:F304	R:R:V49	2.62	No	Yes	0	6	9
276	R:R:F66	R:R:V62	2.62	Yes	No	0	7	7
277	R:R:R140	R:R:V62	2.62	Yes	No	0	6	7
278	R:R:F96	R:R:V86	2.62	Yes	No	0	6	4
279	R:R:A73	R:R:W153	2.59	No	Yes	0	8	9
280	R:R:F171	R:R:T178	2.59	No	No	0	6	4
281	R:R:F259	R:R:T287	2.59	No	No	0	5	7
282	R:R:H166	R:R:L191	2.57	No	No	0	4	1
283	R:R:I276	R:R:R275	2.51	No	No	0	1	2
284	R:R:F204	R:R:L205	2.44	Yes	No	0	8	4
285	R:R:K220	R:R:W219	2.32	No	Yes	0	3	5
286	R:R:G45	R:R:P299	2.03	No	No	0	7	9
287	R:R:C296	R:R:G42	1.96	No	Yes	0	8	8
288	R:R:C18	R:R:P19	1.88	No	Yes	0	8	4
289	R:R:G42	R:R:V41	1.84	Yes	No	0	8	5
290	R:R:G196	R:R:V264	1.84	No	No	0	5	4
291	R:R:G22	R:R:T282	1.82	No	No	0	2	1
292	R:R:G42	R:R:L78	1.71	Yes	No	0	8	6
293	R:R:C149	R:R:V65	1.71	No	Yes	0	7	6
294	R:R:A106	R:R:S160	1.71	No	No	0	5	7
295	R:R:G196	R:R:L195	1.71	No	No	0	5	5
296	R:R:G42	R:R:N46	1.7	Yes	No	0	8	9
297	R:R:A71	R:R:V49	1.7	No	Yes	0	8	9
298	R:R:A71	R:R:V50	1.7	No	No	0	8	7
299	R:R:A63	R:R:T61	1.68	No	No	0	7	8
300	R:R:K20	R:R:P19	1.67	No	Yes	0	6	4
301	R:R:L195	R:R:P162	1.64	No	No	0	5	6
302	R:R:T148	R:R:V144	1.59	No	No	0	5	4
303	R:R:A77	R:R:N111	1.56	No	No	0	6	8
304	R:R:I37	R:R:S36	1.55	No	No	0	5	5
305	R:R:I43	R:R:S47	1.55	No	No	0	6	3
306	R:R:I37	R:R:V41	1.54	No	No	0	5	5
307	R:R:H132	R:R:P133	1.53	No	No	0	6	8
308	R:R:I37	R:R:T33	1.52	No	No	0	5	6
309	R:R:M142	R:R:V62	1.52	No	No	0	1	7
310	R:R:M142	R:R:V65	1.52	No	Yes	0	1	6
311	R:R:F44	R:R:G45	1.51	No	No	0	4	7
312	R:R:L143	R:R:V147	1.49	No	No	0	4	3
313	R:R:N188	R:R:S186	1.49	No	No	0	3	3
314	R:R:L268	R:R:V264	1.49	No	No	0	1	4
315	R:R:L143	R:R:T141	1.47	No	No	0	4	7
316	R:R:I150	R:R:I151	1.47	No	No	0	4	3
317	R:R:L217	R:R:T213	1.47	No	No	0	3	4
318	R:R:I228	R:R:K224	1.45	No	No	0	2	4
319	R:R:F206	R:R:P207	1.44	No	Yes	0	6	8
320	R:R:K318	R:R:L314	1.41	No	No	0	3	3
321	R:R:L314	R:R:L317	1.38	No	No	0	3	6
322	R:R:E227	R:R:I228	1.37	No	No	0	4	2
323	R:R:I228	R:R:Q229	1.37	No	No	0	2	3
324	R:R:A225	R:R:Y226	1.33	No	Yes	0	6	4
325	R:R:N231	R:R:Q229	1.32	No	No	0	4	3
326	R:R:M134	R:R:R137	1.24	No	No	0	6	4
327	R:R:L128	R:R:R139	1.21	No	No	0	5	4
328	R:R:L138	R:R:R139	1.21	No	No	0	4	4
329	R:R:D236	R:R:R234	1.19	No	No	0	4	5
330	R:R:K318	R:R:Y319	1.19	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P19	3.3125	4	0	4
2	R:R:H24	7.3075	4	5	4
3	R:R:I31	3.885	6	0	6
4	R:R:Y35	5.398	5	0	7
5	R:R:G42	1.8025	4	0	8
6	R:R:V49	2.73	4	0	9
7	R:R:Y56	6.816	5	4	4
8	R:R:V65	3.2175	4	0	6
9	R:R:F66	5.04	5	0	7
10	R:R:L70	4.3125	4	6	9
11	R:R:D74	5.61	5	6	9
12	R:R:L81	5.73	4	0	8
13	R:R:W84	7.2025	4	0	7
14	R:R:Y87	7.5575	4	3	5
15	R:R:Y92	7.64	5	3	4
16	R:R:W94	11.054	5	3	9
17	R:R:F96	7.568	5	0	6
18	R:R:F110	4.4075	4	0	5
19	R:R:Y113	5.62	5	2	7
20	R:R:Y127	7.086	5	1	8
21	R:R:R140	5.82	5	0	6
22	R:R:W153	5.7175	4	0	9
23	R:R:F182	8.0725	4	2	4
24	R:R:H183	9.0475	4	7	3
25	R:R:Y184	6.558	5	2	4
26	R:R:K199	11.6825	4	2	5
27	R:R:F204	5.795	4	9	8
28	R:R:P207	3.1325	4	0	8
29	R:R:Y215	5.368	5	0	9
30	R:R:W219	5.268	5	1	5
31	R:R:Y226	4.6775	4	1	4
32	R:R:F239	6.678	5	1	6
33	R:R:F248	7.275	4	10	6
34	R:R:F250	8.585	4	9	5
35	R:R:W253	5.31	4	0	8
36	R:R:I254	5.2025	4	9	5
37	R:R:H256	6.46	6	2	6
38	R:R:Y302	5.706	5	6	9
39	R:R:F309	4.1075	4	4	8
40	R:R:Y312	7.37	6	4	5
41	L:L:R2	7.005	4	0	0
42	L:L:Y4	7.362	5	2	0
43	L:L:I5	4.676	5	3	0
44	L:L:H6	10.0375	4	2	0
45	L:L:F8	8.285	6	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W94	R:R:Y87	13.532	10.61	Yes	Yes	3	9	5
2	R:R:W84	R:R:Y87	26.1927	3.86	Yes	Yes	0	7	5
3	L:L:P7	R:R:W84	35.2811	16.21	No	Yes	0	0	7
4	L:L:P7	R:R:I288	36.1369	5.08	No	No	0	0	6
5	R:R:H256	R:R:I288	40.1797	3.98	Yes	No	0	6	6
6	R:R:H256	R:R:M284	81.9567	3.94	Yes	No	2	6	4
7	L:L:Y4	R:R:M284	70.4558	4.79	Yes	No	2	0	4
8	L:L:Y4	R:R:Y184	57.1813	6.95	Yes	Yes	2	0	4
9	R:R:P192	R:R:Y184	26.1385	4.17	No	Yes	0	3	4
10	R:R:P192	R:R:S189	23.6756	8.91	No	No	0	3	2
11	R:R:E185	R:R:S189	45.5797	4.31	No	No	0	5	2
12	R:R:E185	R:R:H183	38.7179	4.92	No	Yes	0	5	3
13	R:R:Q267	R:R:Y184	25.273	12.4	No	Yes	0	3	4
14	R:R:Q267	R:R:S189	23.6311	5.78	No	No	0	3	2
15	R:R:E173	R:R:N174	10.6548	3.94	No	No	8	3	3
16	R:R:N174	R:R:P19	14.229	3.26	No	Yes	0	3	4
17	R:R:D16	R:R:P19	23.0677	6.44	No	Yes	0	4	4
18	L:L:V3	R:R:D16	24.8238	5.84	No	No	0	0	4
19	L:L:?1	L:L:V3	26.5761	4.62	No	No	0	0	0
20	L:L:?1	R:R:H183	30.0689	14.62	No	Yes	0	0	3
21	L:L:H6	R:R:D281	10.2385	11.35	Yes	No	0	0	4
22	L:L:H6	R:R:M284	10.9511	9.19	Yes	No	2	0	4
23	R:R:I31	R:R:Y35	10.953	6.04	Yes	Yes	0	6	7
24	R:R:L81	R:R:Y35	10.6858	8.21	Yes	Yes	0	8	7
25	R:R:D74	R:R:L70	52.4222	4.07	Yes	Yes	6	9	9
26	R:R:L70	R:R:Y302	53.4445	3.52	Yes	Yes	6	9	9
27	R:R:R126	R:R:Y302	54.2441	7.2	No	Yes	0	9	9
28	R:R:R126	R:R:Y215	54.6623	8.23	No	Yes	0	9	9
29	R:R:S123	R:R:Y215	99.6321	5.09	No	Yes	0	9	9
30	R:R:I211	R:R:S123	99.5895	4.64	No	No	0	8	9
31	R:R:F249	R:R:I211	99.5798	5.02	No	No	0	9	8
32	R:R:F249	R:R:W253	99.5934	5.01	No	Yes	0	9	8
33	R:R:L112	R:R:W253	100	3.42	No	Yes	0	7	8
34	L:L:F8	R:R:L112	89.5311	4.87	Yes	No	0	0	7
35	L:L:F8	R:R:H256	94.3986	7.92	Yes	Yes	2	0	6
36	R:R:D74	R:R:N298	52.3447	6.73	Yes	No	6	9	9
37	R:R:N298	R:R:Y302	53.4541	3.49	No	Yes	6	9	9
38	R:R:I245	R:R:Y302	54.7979	8.46	No	Yes	0	8	9
39	R:R:I245	R:R:Y215	56.4301	4.84	No	Yes	0	8	9
40	R:R:D74	R:R:N46	97.8334	6.73	Yes	No	0	9	9
41	R:R:N46	R:R:P299	79.1686	11.4	No	No	0	9	9
42	R:R:F304	R:R:V49	45.8992	2.62	No	Yes	0	6	9
43	R:R:P299	R:R:V49	72.1054	3.53	No	Yes	0	9	9
44	R:R:Y312	R:R:Y56	21.7627	10.92	Yes	Yes	4	5	4
45	R:R:F309	R:R:Y312	31.4959	4.13	Yes	Yes	4	8	5
46	R:R:F304	R:R:F309	38.7779	5.36	No	Yes	0	6	8
47	R:R:I53	R:R:V49	19.6852	3.07	No	Yes	0	7	9
48	R:R:I53	R:R:L68	17.2378	4.28	No	No	0	7	5
49	R:R:L59	R:R:L68	12.3316	5.54	No	No	0	7	5
50	R:R:C149	R:R:N69	10.0759	7.87	No	No	0	7	9
51	R:R:N69	R:R:W153	23.029	6.78	No	Yes	0	9	9
52	R:R:F110	R:R:W153	26.3108	7.02	Yes	Yes	0	5	9
53	R:R:A156	R:R:F110	31.7902	2.77	No	Yes	0	8	5
54	R:R:A156	R:R:F117	32.9074	2.77	No	No	0	8	5
55	R:R:F117	R:R:Y113	35.1417	6.19	No	Yes	0	5	7
56	R:R:K199	R:R:Y113	15.0558	4.78	Yes	Yes	2	5	7
57	R:R:H256	R:R:K199	15.2339	7.86	Yes	Yes	2	6	5
58	L:L:F8	R:R:Y113	24.5295	4.13	Yes	Yes	2	0	7
59	R:R:C121	R:R:I152	11.6229	3.27	No	No	0	7	7
60	R:R:I152	R:R:L118	11.5687	2.85	No	No	0	7	7
61	R:R:L118	R:R:N69	11.892	4.12	No	No	0	7	9
62	R:R:C121	R:R:F66	11.6926	4.19	No	Yes	0	7	7
63	R:R:F66	R:R:T148	11.9385	5.19	Yes	No	0	7	5
64	R:R:L81	R:R:Y292	12.014	8.21	Yes	No	0	8	7
65	R:R:R140	R:R:V62	13.29	2.62	Yes	No	0	6	7
66	R:R:L128	R:R:R140	18.175	3.64	No	Yes	0	5	6
67	R:R:I242	R:R:Y215	34.2917	3.63	No	Yes	0	7	9
68	R:R:I242	R:R:W219	33.6199	5.87	No	Yes	0	7	5
69	R:R:F239	R:R:W219	29.9411	10.02	Yes	Yes	1	6	5
70	R:R:F239	R:R:L222	24.3959	4.87	Yes	No	1	6	8
71	R:R:I218	R:R:L222	22.8721	2.85	No	No	1	8	8
72	R:R:I218	R:R:Y127	22.2584	3.63	No	Yes	1	8	8
73	L:L:R2	R:R:Y184	10.2753	5.14	Yes	Yes	0	0	4
74	R:R:H256	R:R:T287	16.1749	8.21	Yes	No	0	6	7
75	R:R:P255	R:R:T287	13.3926	3.5	No	No	0	9	7
76	R:R:I254	R:R:P255	10.6916	5.08	Yes	No	0	5	9
77	L:L:R2	R:R:I266	24.2565	5.01	Yes	No	0	0	2
78	R:R:I266	R:R:I271	17.1991	5.89	No	No	0	2	1
79	R:R:T148	R:R:V144	10.314	1.59	No	No	0	5	4
80	R:R:G42	R:R:N46	17.2378	1.7	Yes	No	0	8	9
81	R:R:L112	R:R:Y292	12.4361	7.03	No	No	0	7	7
82	R:R:L128	R:R:Y127	17.1817	3.52	No	Yes	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F170	R:R:I14	10.05	7	No	No	3	3	2	2
R:R:H183	R:R:I14	13.26	7	Yes	No	3	3	1	2
R:R:D16	R:R:P19	6.44	0	No	Yes	4	4	1	2
L:L:V3	R:R:D16	5.84	0	No	No	0	4	0	1
L:L:?1	R:R:D17	4.21	0	No	No	0	6	0	1
R:R:A21	R:R:D281	4.63	0	No	No	4	4	2	1
R:R:R23	R:R:Y92	7.2	3	No	Yes	4	4	1	1
L:L:I5	R:R:R23	3.76	3	Yes	No	0	4	0	1
R:R:F28	R:R:Y92	4.13	0	No	Yes	4	4	2	1
R:R:I31	R:R:Y35	6.04	0	Yes	Yes	6	7	2	2
R:R:I31	R:R:P285	5.08	0	Yes	No	6	5	2	1
R:R:I288	R:R:Y35	6.04	0	No	Yes	6	7	1	2
R:R:T80	R:R:W84	4.85	0	No	Yes	7	7	2	1
R:R:W84	R:R:Y87	3.86	0	Yes	Yes	7	5	1	1
R:R:A104	R:R:W84	3.89	0	No	Yes	6	7	2	1
L:L:P7	R:R:W84	16.21	0	No	Yes	0	7	0	1
R:R:Y87	R:R:Y92	10.92	3	Yes	Yes	5	4	1	1
R:R:W94	R:R:Y87	10.61	3	Yes	Yes	9	5	2	1
L:L:I5	R:R:Y87	4.84	3	Yes	Yes	0	5	0	1
R:R:T88	R:R:Y92	7.49	0	No	Yes	5	4	2	1
L:L:I5	R:R:Y92	8.46	3	Yes	Yes	0	4	0	1
R:R:V108	R:R:Y292	3.79	0	No	No	6	7	1	2
L:L:F8	R:R:V108	3.93	2	Yes	No	0	6	0	1
R:R:S109	R:R:S160	6.52	0	No	No	4	7	1	2
R:R:A163	R:R:S109	3.42	0	No	No	4	4	2	1
L:L:F8	R:R:S109	5.28	2	Yes	No	0	4	0	1
R:R:L112	R:R:W253	3.42	0	No	Yes	7	8	1	2
R:R:L112	R:R:Y292	7.03	0	No	No	7	7	1	2
L:L:F8	R:R:L112	4.87	2	Yes	No	0	7	0	1
R:R:F117	R:R:Y113	6.19	0	No	Yes	5	7	2	1
R:R:A159	R:R:Y113	8.01	0	No	Yes	5	7	2	1
R:R:T198	R:R:Y113	4.99	0	No	Yes	3	7	2	1
R:R:K199	R:R:Y113	4.78	2	Yes	Yes	5	7	1	1
L:L:F8	R:R:Y113	4.13	2	Yes	Yes	0	7	0	1
R:R:F182	R:R:R167	17.1	2	Yes	No	4	5	1	2
R:R:F170	R:R:H183	3.39	7	No	Yes	3	3	2	1
R:R:F182	R:R:Y184	4.13	2	Yes	Yes	4	4	1	1
R:R:F182	R:R:L195	4.87	2	Yes	No	4	5	1	2
L:L:Y4	R:R:F182	6.19	2	Yes	Yes	0	4	0	1
R:R:E185	R:R:H183	4.92	0	No	Yes	5	3	2	1
L:L:?1	R:R:H183	14.62	0	No	Yes	0	3	0	1
R:R:P192	R:R:Y184	4.17	0	No	Yes	3	4	2	1
R:R:Q267	R:R:Y184	12.4	0	No	Yes	3	4	2	1
L:L:R2	R:R:Y184	5.14	0	Yes	Yes	0	4	0	1
L:L:Y4	R:R:Y184	6.95	2	Yes	Yes	0	4	0	1
R:R:H256	R:R:K199	7.86	2	Yes	Yes	6	5	1	1
R:R:K199	R:R:T260	10.51	2	Yes	No	5	6	1	2
L:L:F8	R:R:K199	23.58	2	Yes	Yes	0	5	0	1
R:R:H256	R:R:T260	6.85	2	Yes	No	6	6	1	2
R:R:H256	R:R:M284	3.94	2	Yes	No	6	4	1	1
R:R:H256	R:R:T287	8.21	2	Yes	No	6	7	1	2
R:R:H256	R:R:I288	3.98	2	Yes	No	6	6	1	1
L:L:F8	R:R:H256	7.92	2	Yes	Yes	0	6	0	1
L:L:R2	R:R:D263	7.15	0	Yes	No	0	4	0	1
L:L:Y4	R:R:D263	6.9	2	Yes	No	0	4	0	1
R:R:I266	R:R:I271	5.89	0	No	No	2	1	1	2
R:R:I266	R:R:V280	4.61	0	No	No	2	4	1	2
L:L:R2	R:R:I266	5.01	0	Yes	No	0	2	0	1
L:L:R2	R:R:D281	10.72	0	Yes	No	0	4	0	1
L:L:H6	R:R:D281	11.35	2	Yes	No	0	4	0	1
L:L:Y4	R:R:M284	4.79	2	Yes	No	0	4	0	1
L:L:H6	R:R:M284	9.19	2	Yes	No	0	4	0	1
L:L:H6	R:R:P285	7.63	2	Yes	No	0	5	0	1
L:L:P7	R:R:I288	5.08	0	No	No	0	6	0	1
L:L:I5	R:R:A181	3.25	3	Yes	No	0	5	0	1
R:R:I172	R:R:V179	3.07	0	No	No	5	3	2	1
L:L:I5	R:R:V179	3.07	3	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F6G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	297
Number of Links	330
Number of Hubs	45
Number of Links mediated by Hubs	178
Number of Communities	10
Number of Nodes involved in Communities	58
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	105441
Length Of Smallest Path	3
Average Path Length	18.3662
Length of Longest Path	40
Minimum Path Strength	1.21
Average Path Strength	5.62416
Maximum Path Strength	17.21
Minimum Path Correlation	0.7
Average Path Correlation	0.938909
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	46.5109
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7379
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SAR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SAR
Name	Sarcosine
Synonyms	Sarcosine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	7311726
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	0
Total Bonds	12
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?401
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30556
Sequence	>7F6G_nogp_Chain_R I K R I Q D D C P K A G R H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y M K L K T V A S V F L L N L A L A D L C A L L T L P L W A V Y T A M E Y R W P F G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H P M K S R L R R T M L V A K V T C I I I W L L A G L A S L P A I I H R N V F F I E N T N I T V C A F H Y E S Q N S T L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A Y E I Q K N K P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G I I R D C R I A D I V D T A M P I T I C I A Y F N A C L N P L F Y G F L G K K F K R Y F L Q L L K Y I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9EAH	A	Peptide	Angiotensin	AT₁	Homo sapiens	Olmesartan	Nanobody AT209	-	3.1	2025-03-05	doi.org/10.1073/pnas.2423931122
	9EAI	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	Nanobody AT209	-	3.1	2025-03-05	doi.org/10.1073/pnas.2423931122
	9EAJ	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	Nanobody AT209	-	3.2	2025-03-05	doi.org/10.1073/pnas.2423931122
	8TH4	A	Peptide	Angiotensin	AT₁	Homo sapiens	Losartan	AT118-L Nanobody	-	3.3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	4YAY	A	Peptide	Angiotensin	AT₁	Homo sapiens	ZD-7155	-	-	2.9	2015-04-22	doi.org/10.1016/j.cell.2015.04.011
	6DO1	A	Peptide	Angiotensin	AT₁	Homo sapiens	Angiotensin-like peptide S1I8	-	-	2.9	2019-01-30	doi.org/10.1016/j.cell.2018.12.006
	4ZUD	A	Peptide	Angiotensin	AT₁	Homo sapiens	Olmesartan	-	-	2.8	2015-10-07	doi.org/10.1074/jbc.M115.689000
	6OS0	A	Peptide	Angiotensin	AT₁	Homo sapiens	Angiotensinogen	-	-	2.9	2020-02-19	doi.org/10.1126/science.aay9813
	6OS1	A	Peptide	Angiotensin	AT₁	Homo sapiens	TRV026	-	-	2.79	2020-02-19	doi.org/10.1126/science.aay9813
	6OS2	A	Peptide	Angiotensin	AT₁	Homo sapiens	TRV026	-	-	2.7	2020-02-19	doi.org/10.1126/science.aay9813
	7F6G	A	Peptide	Angiotensin	AT₁	Homo sapiens	SAR1-AngII	-	Gq/β1/γ2	2.9	2023-03-29	doi.org/10.15252/embj.2022112940
	7F6G (No Gprot)	A	Peptide	Angiotensin	AT₁	Homo sapiens	SAR1-AngII	-		2.9	2023-03-29	doi.org/10.15252/embj.2022112940

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