psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R82	16.28	Yes	No	0	0	4
2	L:L:?1	R:R:R95	15.26	Yes	No	0	0	7
3	L:L:?1	R:R:K96	9.45	Yes	No	0	0	5
4	L:L:?1	R:R:L98	11.59	Yes	No	0	0	4
5	L:L:?1	R:R:V99	4.99	Yes	No	1	0	5
6	L:L:?1	R:R:W158	7.63	Yes	Yes	1	0	3
7	L:L:?1	R:R:Y250	12.76	Yes	No	1	0	3
8	L:L:?1	R:R:Y254	19.64	Yes	Yes	1	0	3
9	R:R:L255	R:R:T27	2.95	No	No	0	3	2
10	R:R:F30	R:R:L255	10.96	No	No	0	5	3
11	R:R:L83	R:R:T31	4.42	No	No	0	6	4
12	R:R:I37	R:R:L33	4.28	Yes	No	0	7	5
13	R:R:L33	R:R:S259	4.5	No	No	0	5	5
14	R:R:Q79	R:R:T34	8.5	Yes	No	0	6	7
15	R:R:C35	R:R:L83	3.17	No	No	0	4	6
16	R:R:I36	R:R:I37	2.94	No	Yes	0	4	7
17	R:R:I37	R:R:L263	2.85	Yes	No	0	7	5
18	R:R:I37	R:R:S266	3.1	Yes	No	0	7	8
19	R:R:Q79	R:R:S38	2.89	Yes	No	0	6	5
20	R:R:I80	R:R:S38	4.64	No	No	0	7	5
21	R:R:S266	R:R:V40	3.23	No	No	0	8	5
22	R:R:G41	R:R:S266	3.71	No	No	0	9	8
23	R:R:F73	R:R:L42	4.87	No	No	0	6	6
24	R:R:L42	R:R:L76	4.15	No	Yes	0	6	7
25	R:R:I80	R:R:L42	2.85	No	No	0	7	6
26	R:R:G44	R:R:T43	3.64	No	No	0	8	5
27	R:R:D72	R:R:N45	5.39	No	No	0	9	9
28	R:R:N45	R:R:P269	8.15	No	No	0	9	9
29	R:R:L51	R:R:V47	2.98	Yes	No	0	7	7
30	R:R:A69	R:R:V48	3.39	No	Yes	0	9	9
31	R:R:F273	R:R:V48	3.93	Yes	Yes	0	7	9
32	R:R:F73	R:R:L49	3.65	No	No	0	6	7
33	R:R:R55	R:R:W50	3	No	No	0	5	5
34	R:R:L51	R:R:R55	9.72	Yes	No	0	7	5
35	R:R:L51	R:R:M56	4.24	Yes	No	0	7	7
36	R:R:L52	R:R:S62	3	No	No	0	7	8
37	R:R:F273	R:R:L52	7.31	Yes	No	0	7	7
38	R:R:R57	R:R:R58	5.33	No	No	0	5	6
39	R:R:A60	R:R:N59	3.13	No	No	0	7	8
40	R:R:A60	R:R:R134	4.15	No	Yes	0	7	8
41	R:R:I63	R:R:S139	10.84	No	No	0	7	9
42	R:R:A115	R:R:Y64	4	No	Yes	0	7	8
43	R:R:I116	R:R:Y64	3.63	Yes	Yes	0	8	8
44	R:R:E119	R:R:Y64	7.86	No	Yes	0	8	8
45	R:R:S139	R:R:Y64	6.36	No	Yes	0	9	8
46	R:R:V142	R:R:Y64	3.79	No	Yes	0	7	8
47	R:R:C143	R:R:Y64	2.69	No	Yes	0	7	8
48	R:R:C143	R:R:N67	6.3	No	No	0	7	9
49	R:R:L68	R:R:M112	2.83	No	No	0	9	7
50	R:R:L113	R:R:L68	4.15	No	No	3	9	9
51	R:R:L68	R:R:N268	5.49	No	Yes	3	9	9
52	R:R:D72	R:R:S265	7.36	No	No	0	9	9
53	R:R:D72	R:R:N268	4.04	No	Yes	0	9	9
54	R:R:L74	R:R:P105	3.28	No	No	0	6	8
55	R:R:F75	R:R:M102	6.22	No	No	0	6	4
56	R:R:F75	R:R:S261	5.28	No	No	0	6	8
57	R:R:F75	R:R:S265	6.61	No	No	0	6	9
58	R:R:L76	R:R:S262	3	Yes	No	0	7	6
59	R:R:L76	R:R:S265	3	Yes	No	0	7	9
60	R:R:F78	R:R:S77	3.96	No	No	0	6	5
61	R:R:F78	R:R:M102	7.46	No	No	0	6	4
62	R:R:Q79	R:R:R82	3.5	Yes	No	0	6	4
63	R:R:Q79	R:R:S262	2.89	Yes	No	0	6	6
64	R:R:I81	R:R:L85	2.85	No	No	0	5	4
65	R:R:M258	R:R:R82	3.72	Yes	No	0	4	4
66	R:R:L83	R:R:P84	6.57	No	No	0	6	4
67	R:R:I88	R:R:L87	4.28	No	No	0	4	4
68	R:R:I90	R:R:R95	18.79	No	No	0	3	7
69	R:R:H92	R:R:R95	13.54	No	No	0	6	7
70	R:R:I94	R:R:I97	5.89	No	No	0	5	4
71	R:R:K96	R:R:Y240	3.58	No	No	0	5	4
72	R:R:V99	R:R:W158	8.58	No	Yes	1	5	3
73	R:R:F160	R:R:S100	7.93	No	No	0	4	4
74	R:R:M102	R:R:M258	4.33	No	Yes	0	4	4
75	R:R:F107	R:R:T103	3.89	Yes	Yes	1	6	4
76	R:R:S154	R:R:T103	3.2	No	Yes	1	6	4
77	R:R:E157	R:R:T103	2.82	Yes	Yes	1	5	4
78	R:R:T103	R:R:W158	6.06	Yes	Yes	1	4	3
79	R:R:F104	R:R:P105	5.78	Yes	No	0	5	8
80	R:R:F104	R:R:W147	4.01	Yes	No	0	5	9
81	R:R:F104	R:R:S150	5.28	Yes	No	0	5	8
82	R:R:F104	R:R:L151	7.31	Yes	No	0	5	3
83	R:R:F107	R:R:Y106	5.16	Yes	Yes	0	6	8
84	R:R:L110	R:R:Y106	4.69	No	Yes	0	7	8
85	R:R:F232	R:R:Y106	15.47	Yes	Yes	0	6	8
86	R:R:G233	R:R:Y106	4.35	No	Yes	0	8	8
87	R:R:F107	R:R:S154	6.61	Yes	No	1	6	6
88	R:R:E157	R:R:F107	9.33	Yes	Yes	1	5	6
89	R:R:F107	R:R:W183	3.01	Yes	Yes	0	6	5
90	R:R:T108	R:R:W147	13.34	Yes	No	0	7	9
91	R:R:S150	R:R:T108	4.8	No	Yes	0	8	7
92	R:R:F225	R:R:L110	6.09	No	No	4	9	7
93	R:R:L110	R:R:L230	2.77	No	No	4	7	5
94	R:R:L146	R:R:M112	5.65	No	No	0	6	7
95	R:R:L113	R:R:N268	2.75	No	Yes	3	9	9
96	R:R:L113	R:R:Y272	5.86	No	Yes	0	9	9
97	R:R:L187	R:R:S114	6.01	No	No	0	8	7
98	R:R:I116	R:R:R120	5.01	Yes	No	0	8	9
99	R:R:I116	R:R:Y272	6.04	Yes	Yes	0	8	9
100	R:R:L191	R:R:S117	3	No	No	0	8	9
101	R:R:S117	R:R:S194	3.26	No	No	0	9	8
102	R:R:S194	R:R:T118	6.4	No	No	0	8	6
103	R:R:E119	R:R:Y130	7.86	No	Yes	2	8	7
104	R:R:E119	R:R:R134	4.65	No	Yes	2	8	8
105	R:R:C121	R:R:L125	3.17	No	No	0	7	7
106	R:R:C121	R:R:V197	3.42	No	No	0	7	5
107	R:R:S123	R:R:Y130	10.17	No	Yes	0	8	7
108	R:R:L125	R:R:W126	3.42	No	No	0	7	5
109	R:R:L125	R:R:R201	7.29	No	No	0	7	6
110	R:R:W129	R:R:Y130	3.86	No	Yes	2	4	7
111	R:R:R133	R:R:W129	12	No	No	0	4	4
112	R:R:R134	R:R:W129	5	Yes	No	2	8	4
113	R:R:R134	R:R:Y130	11.32	Yes	Yes	2	8	7
114	R:R:P135	R:R:R134	2.88	No	Yes	0	7	8
115	R:R:H137	R:R:T136	2.74	No	No	0	5	5
116	R:R:L138	R:R:V142	2.98	No	No	0	4	7
117	R:R:L146	R:R:V142	2.98	No	No	0	6	7
118	R:R:L145	R:R:L149	2.77	No	No	0	4	5
119	R:R:F153	R:R:L152	6.09	No	No	0	4	4
120	R:R:F153	R:R:W183	14.03	No	Yes	0	4	5
121	R:R:E157	R:R:W158	4.36	Yes	Yes	1	5	3
122	R:R:E157	R:R:G236	4.91	Yes	No	1	5	4
123	R:R:A237	R:R:E157	3.02	No	Yes	0	5	5
124	R:R:F232	R:R:W158	3.01	Yes	Yes	1	6	3
125	R:R:G236	R:R:W158	9.85	No	Yes	1	4	3
126	R:R:W158	R:R:Y254	5.79	Yes	Yes	1	3	3
127	R:R:C173	R:R:R159	4.18	No	Yes	0	3	3
128	R:R:E174	R:R:R159	8.14	No	Yes	0	2	3
129	R:R:R159	R:R:Y240	9.26	Yes	No	0	3	4
130	R:R:R159	R:R:R241	4.26	Yes	No	0	3	3
131	R:R:C161	R:R:C173	7.28	No	No	0	9	3
132	R:R:D177	R:R:F178	9.55	No	No	5	4	4
133	R:R:D177	R:R:R241	10.72	No	No	5	4	3
134	R:R:F178	R:R:R241	11.76	No	No	5	4	3
135	R:R:I179	R:R:P180	5.08	No	No	0	5	5
136	R:R:I185	R:R:V181	3.07	No	No	0	4	4
137	R:R:F186	R:R:W183	3.01	No	Yes	0	5	5
138	R:R:L187	R:R:W183	3.42	No	Yes	0	8	5
139	R:R:L184	R:R:L230	2.77	No	No	0	7	5
140	R:R:F186	R:R:V190	3.93	No	No	0	5	6
141	R:R:L191	R:R:V222	4.47	No	No	0	8	8
142	R:R:F225	R:R:L191	7.31	No	No	0	9	8
143	R:R:S195	R:R:V222	3.23	No	No	0	8	8
144	R:R:I218	R:R:L198	2.85	No	No	0	8	8
145	R:R:L199	R:R:L203	4.15	No	No	6	5	4
146	R:R:L199	R:R:Y215	5.86	No	No	6	5	5
147	R:R:C204	R:R:R201	2.79	No	No	0	4	6
148	R:R:I202	R:R:K208	2.91	No	No	0	7	4
149	R:R:I202	R:R:L214	4.28	No	No	0	7	7
150	R:R:L203	R:R:Y215	4.69	No	No	6	4	5
151	R:R:K208	R:R:P210	8.36	No	No	0	4	5
152	R:R:K208	R:R:L211	5.64	No	No	0	4	6
153	R:R:M209	R:R:P210	3.35	No	No	0	3	5
154	R:R:L211	R:R:L214	2.77	No	No	0	6	7
155	R:R:L211	R:R:Y215	11.72	No	No	0	6	5
156	R:R:R213	R:R:R279	6.4	No	No	0	7	7
157	R:R:L219	R:R:L223	2.77	No	No	0	4	5
158	R:R:I271	R:R:L220	5.71	No	No	0	8	6
159	R:R:T221	R:R:Y272	4.99	No	Yes	0	7	9
160	R:R:F225	R:R:L230	7.31	No	No	4	9	5
161	R:R:G229	R:R:N264	5.09	No	No	0	7	9
162	R:R:F232	R:R:Y254	3.09	Yes	Yes	1	6	3
163	R:R:F232	R:R:M258	4.98	Yes	Yes	1	6	4
164	R:R:F232	R:R:S261	5.28	Yes	No	0	6	8
165	R:R:I239	R:R:L235	4.28	No	No	0	4	3
166	R:R:L235	R:R:V253	2.98	No	No	0	3	4
167	R:R:C257	R:R:L235	3.17	No	No	0	6	3
168	R:R:I239	R:R:Y240	4.84	No	No	0	4	4
169	R:R:I239	R:R:L249	2.85	No	Yes	0	4	1
170	R:R:L244	R:R:M242	2.83	No	No	0	1	1
171	R:R:L249	R:R:M242	2.83	Yes	No	0	1	1
172	R:R:H243	R:R:L246	16.71	No	No	0	2	1
173	R:R:N245	R:R:V248	10.35	No	No	0	2	1
174	R:R:L249	R:R:V253	2.98	Yes	No	0	1	4
175	R:R:Y250	R:R:Y254	3.97	No	Yes	1	3	3
176	R:R:C251	R:R:H252	4.42	No	No	0	2	1
177	R:R:M258	R:R:Y254	7.18	Yes	Yes	1	4	3
178	R:R:L260	R:R:V256	2.98	No	No	0	7	5
179	R:R:N264	R:R:N268	4.09	No	Yes	0	9	9
180	R:R:F274	R:R:I270	3.77	No	No	0	7	6
181	R:R:I271	R:R:Y272	6.04	No	Yes	0	8	9
182	R:R:F273	R:R:F274	4.29	Yes	No	0	7	7
183	R:R:F273	R:R:S277	3.96	Yes	No	0	7	6
184	R:R:F107	R:R:S150	2.64	Yes	No	0	6	8
185	R:R:F30	R:R:V256	2.62	No	No	0	5	5
186	R:R:R213	R:R:T212	2.59	No	No	0	7	5
187	R:R:F273	R:R:L51	2.44	Yes	Yes	0	7	7
188	R:R:L28	R:R:R86	2.43	No	No	0	4	3
189	R:R:L66	R:R:R58	2.43	No	No	0	7	6
190	R:R:L122	R:R:Y130	2.34	No	Yes	0	6	7
191	R:R:G229	R:R:P231	2.03	No	No	0	7	9
192	R:R:A71	R:R:G109	1.95	No	No	0	9	9
193	R:R:G205	R:R:S206	1.86	No	No	0	5	6
194	R:R:G276	R:R:V275	1.84	No	No	0	8	7
195	R:R:G109	R:R:T108	1.82	No	Yes	0	9	7
196	R:R:C188	R:R:C192	1.82	No	No	0	6	5
197	R:R:P269	R:R:V48	1.77	No	Yes	0	9	9
198	R:R:C121	R:R:S194	1.72	No	No	0	7	8
199	R:R:G41	R:R:L76	1.71	No	Yes	0	9	7
200	R:R:G148	R:R:L151	1.71	No	No	0	4	3
201	R:R:C192	R:R:V222	1.71	No	No	0	5	8
202	R:R:C204	R:R:V200	1.71	No	No	0	4	4
203	R:R:C228	R:R:V224	1.71	No	No	0	7	7
204	R:R:A237	R:R:V181	1.7	No	No	0	5	4
205	R:R:L85	R:R:P84	1.64	No	No	0	4	4
206	R:R:L156	R:R:P180	1.64	No	No	0	7	5
207	R:R:A182	R:R:I179	1.62	No	No	0	4	5
208	R:R:A267	R:R:I271	1.62	No	No	0	6	8
209	R:R:S111	R:R:T108	1.6	No	Yes	0	7	7
210	R:R:S176	R:R:T175	1.6	No	No	0	4	4
211	R:R:V189	R:R:V193	1.6	No	No	0	4	3
212	R:R:V193	R:R:V197	1.6	No	No	0	3	5
213	R:R:C188	R:R:L226	1.59	No	No	0	6	7
214	R:R:C228	R:R:L260	1.59	No	No	0	7	7
215	R:R:A70	R:R:L49	1.58	No	No	0	5	7
216	R:R:A237	R:R:L238	1.58	No	No	0	5	5
217	R:R:T217	R:R:T221	1.57	No	No	0	7	7
218	R:R:C228	R:R:N264	1.57	No	No	0	7	9
219	R:R:I94	R:R:S91	1.55	No	No	0	5	3
220	R:R:I218	R:R:S195	1.55	No	No	0	8	8
221	R:R:I65	R:R:V48	1.54	No	Yes	0	8	9
222	R:R:I116	R:R:V61	1.54	Yes	No	0	8	7
223	R:R:I202	R:R:V124	1.54	No	No	0	7	8
224	R:R:M155	R:R:S100	1.53	No	No	0	4	4
225	R:R:G53	R:R:R58	1.5	No	No	0	5	6
226	R:R:L156	R:R:S176	1.5	No	No	0	7	4
227	R:R:G276	R:R:R279	1.5	No	No	0	8	7
228	R:R:L198	R:R:V124	1.49	No	No	0	8	8
229	R:R:L249	R:R:V248	1.49	Yes	No	0	1	1
230	R:R:I90	R:R:I94	1.47	No	No	0	3	5
231	R:R:G53	R:R:Y54	1.45	No	No	0	5	5
232	R:R:I234	R:R:L184	1.43	No	No	0	6	7
233	R:R:I234	R:R:L238	1.43	No	No	0	6	5
234	R:R:L156	R:R:M155	1.41	No	No	0	7	4
235	R:R:C132	R:R:R133	1.39	No	No	0	5	4
236	R:R:L52	R:R:L66	1.38	No	No	0	7	7
237	R:R:P127	R:R:W126	1.35	No	No	0	8	5
238	R:R:C251	R:R:Y250	1.34	No	No	0	2	3
239	R:R:F30	R:R:S29	1.32	No	No	0	5	4
240	R:R:R86	R:R:T31	1.29	No	No	0	3	4
241	R:R:F78	R:R:I81	1.26	No	No	0	6	5
242	R:R:S176	R:R:W172	1.24	No	No	0	4	1
243	R:R:F153	R:R:L149	1.22	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.2	8	1	0
2	R:R:I37	3.2925	4	0	7
3	R:R:V48	2.6575	4	0	9
4	R:R:L51	4.845	4	0	7
5	R:R:Y64	4.72167	6	0	8
6	R:R:L76	2.965	4	0	7
7	R:R:Q79	4.445	4	0	6
8	R:R:T103	3.9925	4	1	4
9	R:R:F104	5.595	4	0	5
10	R:R:Y106	7.4175	4	0	8
11	R:R:F107	5.10667	6	1	6
12	R:R:T108	5.39	4	0	7
13	R:R:I116	4.055	4	0	8
14	R:R:Y130	7.11	5	2	7
15	R:R:R134	5.6	5	2	8
16	R:R:E157	4.888	5	1	5
17	R:R:W158	6.46857	7	1	3
18	R:R:R159	6.46	4	0	3
19	R:R:W183	5.8675	4	0	5
20	R:R:F232	6.366	5	1	6
21	R:R:L249	2.5375	4	0	1
22	R:R:Y254	7.934	5	1	3
23	R:R:M258	5.0525	4	1	4
24	R:R:N268	4.0925	4	3	9
25	R:R:Y272	5.7325	4	0	9
26	R:R:F273	4.386	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R82	29.7389	16.28	Yes	No	0	0	4
2	R:R:Q79	R:R:R82	19.7008	3.5	Yes	No	0	6	4
3	R:R:Q79	R:R:S262	16.5069	2.89	Yes	No	0	6	6
4	R:R:L76	R:R:S262	16.195	3	Yes	No	0	7	6
5	R:R:L76	R:R:S265	25.6036	3	Yes	No	0	7	9
6	R:R:D72	R:R:S265	100	7.36	No	No	0	9	9
7	R:R:D72	R:R:N268	73.4435	4.04	No	Yes	0	9	9
8	R:R:N264	R:R:N268	19.6546	4.09	No	Yes	0	9	9
9	R:R:C228	R:R:N264	14.3525	1.57	No	No	0	7	9
10	R:R:C228	R:R:L260	10.7601	1.59	No	No	0	7	7
11	R:R:M258	R:R:R82	15.6463	3.72	Yes	No	0	4	4
12	R:R:M102	R:R:M258	33.5682	4.33	No	Yes	0	4	4
13	R:R:F75	R:R:M102	29.5541	6.22	No	No	0	6	4
14	R:R:F75	R:R:S265	89.546	6.61	No	No	0	6	9
15	L:L:?1	R:R:Y254	30.1432	19.64	Yes	Yes	1	0	3
16	R:R:M258	R:R:Y254	15.3575	7.18	Yes	Yes	1	4	3
17	L:L:?1	R:R:W158	29.4271	7.63	Yes	Yes	1	0	3
18	R:R:F232	R:R:W158	23.9286	3.01	Yes	Yes	1	6	3
19	R:R:F232	R:R:S261	61.0604	5.28	Yes	No	0	6	8
20	R:R:F75	R:R:S261	60.8121	5.28	No	No	0	6	8
21	R:R:F232	R:R:Y254	20.4632	3.09	Yes	Yes	1	6	3
22	R:R:F78	R:R:M102	13.8674	7.46	No	No	0	6	4
23	R:R:F78	R:R:I81	11.3145	1.26	No	No	0	6	5
24	R:R:G41	R:R:L76	10.067	1.71	No	Yes	0	9	7
25	R:R:D72	R:R:N45	36.8661	5.39	No	No	0	9	9
26	R:R:N45	R:R:P269	35.2258	8.15	No	No	0	9	9
27	R:R:P269	R:R:V48	33.574	1.77	No	Yes	0	9	9
28	R:R:F273	R:R:V48	28.5492	3.93	Yes	Yes	0	7	9
29	R:R:F273	R:R:L52	12.8451	7.31	Yes	No	0	7	7
30	R:R:L113	R:R:N268	48.4348	2.75	No	Yes	3	9	9
31	R:R:L113	R:R:Y272	47.1815	5.86	No	Yes	0	9	9
32	R:R:I116	R:R:Y272	38.2465	6.04	Yes	Yes	0	8	9
33	R:R:I116	R:R:Y64	33.7704	3.63	Yes	Yes	0	8	8
34	R:R:E119	R:R:Y64	24.3156	7.86	No	Yes	0	8	8
35	R:R:E119	R:R:R134	12.3311	4.65	No	Yes	2	8	8
36	R:R:F107	R:R:S150	17.4599	2.64	Yes	No	0	6	8
37	R:R:E157	R:R:W158	11.2857	4.36	Yes	Yes	1	5	3
38	L:L:?1	R:R:R95	19.6777	15.26	Yes	No	0	0	7
39	R:R:I90	R:R:R95	13.1628	18.79	No	No	0	3	7
40	L:L:?1	R:R:K96	58.9581	9.45	Yes	No	0	0	5
41	R:R:K96	R:R:Y240	55.8219	3.58	No	No	0	5	4
42	R:R:F232	R:R:Y106	53.3383	15.47	Yes	Yes	0	6	8
43	R:R:L110	R:R:Y106	44.0684	4.69	No	Yes	0	7	8
44	R:R:F107	R:R:W183	13.2494	3.01	Yes	Yes	0	6	5
45	R:R:F225	R:R:L110	40.3546	6.09	No	No	4	9	7
46	R:R:F225	R:R:L191	40.834	7.31	No	No	0	9	8
47	R:R:L191	R:R:S117	16.8881	3	No	No	0	8	9
48	R:R:S117	R:R:S194	15.6463	3.26	No	No	0	9	8
49	R:R:C121	R:R:S194	13.1281	1.72	No	No	0	7	8
50	R:R:E119	R:R:Y130	10.5464	7.86	No	Yes	2	8	7
51	R:R:R159	R:R:Y240	21.8089	9.26	Yes	No	0	3	4
52	R:R:L191	R:R:V222	26.0945	4.47	No	No	0	8	8
53	R:R:S195	R:R:V222	21.4104	3.23	No	No	0	8	8
54	R:R:I218	R:R:S195	20.2091	1.55	No	No	0	8	8
55	R:R:I218	R:R:L198	19.1579	2.85	No	No	0	8	8
56	R:R:L198	R:R:V124	17.9392	1.49	No	No	0	8	8
57	R:R:I202	R:R:V124	16.8707	1.54	No	No	0	7	8
58	R:R:I239	R:R:Y240	31.9741	4.84	No	No	0	4	4
59	R:R:I239	R:R:L249	19.3601	2.85	No	Yes	0	4	1
60	R:R:F107	R:R:Y106	21.0928	5.16	Yes	Yes	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R82	16.28	1	Yes	No	0	4	0	1
L:L:?1	R:R:R95	15.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:K96	9.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:L98	11.59	1	Yes	No	0	4	0	1
L:L:?1	R:R:V99	4.99	1	Yes	No	0	5	0	1
L:L:?1	R:R:W158	7.63	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y250	12.76	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y254	19.64	1	Yes	Yes	0	3	0	1
R:R:Q79	R:R:R82	3.5	0	Yes	No	6	4	2	1
R:R:M258	R:R:R82	3.72	1	Yes	No	4	4	2	1
R:R:I90	R:R:R95	18.79	0	No	No	3	7	2	1
R:R:H92	R:R:R95	13.54	0	No	No	6	7	2	1
R:R:K96	R:R:Y240	3.58	0	No	No	5	4	1	2
R:R:V99	R:R:W158	8.58	1	No	Yes	5	3	1	1
R:R:E157	R:R:T103	2.82	1	Yes	Yes	5	4	2	2
R:R:T103	R:R:W158	6.06	1	Yes	Yes	4	3	2	1
R:R:E157	R:R:W158	4.36	1	Yes	Yes	5	3	2	1
R:R:E157	R:R:G236	4.91	1	Yes	No	5	4	2	2
R:R:F232	R:R:W158	3.01	1	Yes	Yes	6	3	2	1
R:R:G236	R:R:W158	9.85	1	No	Yes	4	3	2	1
R:R:W158	R:R:Y254	5.79	1	Yes	Yes	3	3	1	1
R:R:F232	R:R:Y254	3.09	1	Yes	Yes	6	3	2	1
R:R:F232	R:R:M258	4.98	1	Yes	Yes	6	4	2	2
R:R:Y250	R:R:Y254	3.97	1	No	Yes	3	3	1	1
R:R:M258	R:R:Y254	7.18	1	Yes	Yes	4	3	2	1
R:R:C251	R:R:Y250	1.34	0	No	No	2	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7S8P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	227
Number of Links	243
Number of Hubs	26
Number of Links mediated by Hubs	101
Number of Communities	6
Number of Nodes involved in Communities	28
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	32540
Length Of Smallest Path	3
Average Path Length	13.38
Length of Longest Path	29
Minimum Path Strength	1.37
Average Path Strength	5.60103
Maximum Path Strength	17.8967
Minimum Path Correlation	0.7
Average Path Correlation	0.917312
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	46.7341
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.7702
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8IX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8IX
Name	N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine
Synonyms
Identifier
Formula	C22 H29 N O3
Molecular Weight	355.471
SMILES
PubChem
Formal Charge	0
Total Atoms	55
Total Chiral Atoms	3
Total Bonds	58
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LA9
Sequence	>7S8P_nogp_Chain_R Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M R R N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L I N I S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W P I W Y R C R R P T H L S A V V C V L L W G L S L L F S M L E W R F C D F W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C G S R K M P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L I Y R M H L N L E V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7S8P	A	Orphan	Orphan	MRGPRX4	Homo sapiens	MS47134	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8P (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	MS47134	-		2.6	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	8YRG	A	Orphan	Orphan	MRGPRX4	Homo sapiens	Fospropofol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2024-05-22	doi.org/10.1126/scitranslmed.adk8198
	8YRG (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	Fospropofol	-		3.14	2024-05-22	doi.org/10.1126/scitranslmed.adk8198
	8K4S	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.9	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8K4S (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-		2.9	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8KEX	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-	-	3.2	2024-11-06	doi.org/10.1016/j.cell.2024.10.001

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7S8P_nogp.zip

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