psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R95	12.38	Yes	Yes	0	0	7
2	L:L:?1	R:R:K96	8.62	Yes	No	0	0	5
3	L:L:?1	R:R:V99	9.11	Yes	No	0	0	5
4	L:L:?1	R:R:T103	5.01	Yes	No	0	0	4
5	L:L:?1	R:R:F107	5.79	Yes	No	0	0	6
6	L:L:?1	R:R:L156	31.97	Yes	No	4	0	7
7	L:L:?1	R:R:P180	6.69	Yes	No	4	0	5
8	L:L:?1	R:R:G236	10.46	Yes	No	0	0	4
9	L:L:?1	R:R:I239	7.76	Yes	No	0	0	4
10	L:L:?1	R:R:Y240	8.76	Yes	Yes	4	0	4
11	L:L:?1	R:R:L246	9.4	Yes	No	0	0	1
12	L:L:?1	R:R:Y254	7.17	Yes	Yes	0	0	3
13	R:R:P22	R:R:T27	15.74	No	No	0	3	2
14	R:R:P22	R:R:R86	7.21	No	No	0	3	3
15	R:R:C23	R:R:C251	7.28	No	No	0	2	2
16	R:R:F30	R:R:Q26	9.37	No	No	0	5	2
17	R:R:H252	R:R:Q26	4.95	No	No	0	1	2
18	R:R:F30	R:R:L255	7.31	No	No	0	5	3
19	R:R:L83	R:R:T31	5.9	No	No	0	6	4
20	R:R:L83	R:R:T34	4.42	No	No	0	6	7
21	R:R:M258	R:R:T34	9.03	No	No	0	4	7
22	R:R:S259	R:R:T34	4.8	No	No	0	5	7
23	R:R:I37	R:R:S262	4.64	No	No	0	7	6
24	R:R:I37	R:R:L263	4.28	No	No	0	7	5
25	R:R:I80	R:R:S38	4.64	No	No	0	7	5
26	R:R:S262	R:R:S38	4.89	No	No	0	6	5
27	R:R:S266	R:R:V40	4.85	No	No	0	8	5
28	R:R:G41	R:R:S266	3.71	No	No	0	9	8
29	R:R:F73	R:R:L42	9.74	No	No	0	6	6
30	R:R:I80	R:R:L42	4.28	No	No	0	7	6
31	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
32	R:R:N45	R:R:P269	11.4	No	No	0	9	9
33	R:R:F274	R:R:V47	3.93	Yes	No	0	7	7
34	R:R:P269	R:R:V48	3.53	No	Yes	0	9	9
35	R:R:F273	R:R:V48	5.24	Yes	Yes	0	7	9
36	R:R:W50	R:R:Y54	4.82	No	No	6	5	5
37	R:R:R55	R:R:W50	5	No	No	6	5	5
38	R:R:F273	R:R:L51	6.09	Yes	No	0	7	7
39	R:R:L52	R:R:M56	11.31	No	No	5	7	7
40	R:R:F273	R:R:L52	14.61	Yes	No	5	7	7
41	R:R:G53	R:R:R58	4.5	No	No	0	5	6
42	R:R:R55	R:R:Y54	6.17	No	No	6	5	5
43	R:R:M56	R:R:S62	4.6	No	No	0	7	8
44	R:R:F273	R:R:M56	7.46	Yes	No	5	7	7
45	R:R:I63	R:R:R58	5.01	No	No	0	7	6
46	R:R:A60	R:R:Y130	4	No	Yes	0	7	7
47	R:R:V61	R:R:Y64	3.79	No	Yes	0	7	8
48	R:R:I63	R:R:S139	9.29	No	No	0	7	9
49	R:R:A115	R:R:Y64	5.34	No	Yes	0	7	8
50	R:R:I116	R:R:Y64	3.63	No	Yes	0	8	8
51	R:R:E119	R:R:Y64	11.22	No	Yes	0	8	8
52	R:R:S139	R:R:Y64	6.36	No	Yes	0	9	8
53	R:R:V142	R:R:Y64	8.83	No	Yes	0	7	8
54	R:R:M112	R:R:N67	11.22	No	No	1	7	9
55	R:R:C143	R:R:N67	7.87	No	No	0	7	9
56	R:R:N67	R:R:W147	5.65	No	Yes	1	9	9
57	R:R:D72	R:R:L68	5.43	Yes	No	2	9	9
58	R:R:L113	R:R:L68	4.15	Yes	No	2	9	9
59	R:R:L68	R:R:N268	6.87	No	Yes	2	9	9
60	R:R:D72	R:R:S265	8.83	Yes	No	0	9	9
61	R:R:D72	R:R:N268	6.73	Yes	Yes	2	9	9
62	R:R:F78	R:R:L74	6.09	Yes	No	1	6	6
63	R:R:L74	R:R:P105	4.93	No	No	1	6	8
64	R:R:F75	R:R:M102	6.22	Yes	Yes	0	6	4
65	R:R:F75	R:R:Y106	6.19	Yes	Yes	0	6	8
66	R:R:F75	R:R:S261	5.28	Yes	No	0	6	8
67	R:R:F75	R:R:S265	7.93	Yes	No	0	6	9
68	R:R:L76	R:R:S265	6.01	No	No	0	7	9
69	R:R:F78	R:R:V101	3.93	Yes	No	0	6	5
70	R:R:F78	R:R:M102	3.73	Yes	Yes	1	6	4
71	R:R:F78	R:R:P105	4.33	Yes	No	1	6	8
72	R:R:Q79	R:R:R82	3.5	No	Yes	1	6	4
73	R:R:M102	R:R:Q79	5.44	Yes	No	1	4	6
74	R:R:M258	R:R:Q79	9.52	No	No	0	4	6
75	R:R:R82	R:R:R95	4.26	Yes	Yes	0	4	7
76	R:R:L98	R:R:R82	6.07	No	Yes	0	4	4
77	R:R:R82	R:R:V99	6.54	Yes	No	0	4	5
78	R:R:M102	R:R:R82	7.44	Yes	Yes	1	4	4
79	R:R:R82	R:R:Y254	8.23	Yes	Yes	0	4	3
80	R:R:L83	R:R:P84	4.93	No	No	0	6	4
81	R:R:I88	R:R:N89	7.08	No	No	0	4	3
82	R:R:H92	R:R:I90	3.98	No	No	0	6	3
83	R:R:I94	R:R:S91	6.19	No	No	0	5	3
84	R:R:S100	R:R:W158	12.36	No	No	0	4	3
85	R:R:F104	R:R:P105	7.22	Yes	No	1	5	8
86	R:R:F104	R:R:T108	5.19	Yes	Yes	1	5	7
87	R:R:F104	R:R:W147	6.01	Yes	Yes	1	5	9
88	R:R:F104	R:R:S150	7.93	Yes	No	1	5	8
89	R:R:F104	R:R:L151	9.74	Yes	No	0	5	3
90	R:R:L110	R:R:Y106	9.38	No	Yes	0	7	8
91	R:R:F232	R:R:Y106	10.32	No	Yes	0	6	8
92	R:R:G233	R:R:Y106	5.79	No	Yes	0	8	8
93	R:R:T108	R:R:W147	15.77	Yes	Yes	1	7	9
94	R:R:S150	R:R:T108	6.4	No	Yes	1	8	7
95	R:R:F225	R:R:L110	9.74	Yes	No	0	9	7
96	R:R:L146	R:R:S111	12.01	No	No	0	6	7
97	R:R:L146	R:R:M112	4.24	No	No	0	6	7
98	R:R:M112	R:R:W147	3.49	No	Yes	1	7	9
99	R:R:F225	R:R:L113	6.09	Yes	Yes	0	9	9
100	R:R:L113	R:R:N268	12.36	Yes	Yes	2	9	9
101	R:R:L113	R:R:Y272	4.69	Yes	Yes	2	9	9
102	R:R:S114	R:R:V190	4.85	No	No	0	7	6
103	R:R:I116	R:R:R120	3.76	No	No	0	8	9
104	R:R:I116	R:R:Y272	8.46	No	Yes	0	8	9
105	R:R:L191	R:R:S117	6.01	No	No	0	8	9
106	R:R:S117	R:R:S194	4.89	No	Yes	0	9	8
107	R:R:S194	R:R:T118	4.8	Yes	No	0	8	6
108	R:R:E119	R:R:Y130	12.35	No	Yes	3	8	7
109	R:R:E119	R:R:R134	5.82	No	Yes	3	8	8
110	R:R:I218	R:R:R120	3.76	No	No	0	8	9
111	R:R:C121	R:R:S194	3.44	No	Yes	0	7	8
112	R:R:C121	R:R:V197	3.42	No	No	0	7	5
113	R:R:S123	R:R:Y130	8.9	No	Yes	0	8	7
114	R:R:L198	R:R:V124	5.96	No	No	0	8	8
115	R:R:L125	R:R:V197	4.47	No	No	0	7	5
116	R:R:L125	R:R:R201	4.86	No	No	0	7	6
117	R:R:W129	R:R:Y130	7.72	No	Yes	3	4	7
118	R:R:R133	R:R:W129	9	No	No	0	4	4
119	R:R:R134	R:R:W129	9	Yes	No	3	8	4
120	R:R:R134	R:R:Y130	14.4	Yes	Yes	3	8	7
121	R:R:P135	R:R:R134	4.32	No	Yes	3	7	8
122	R:R:L138	R:R:R134	4.86	No	Yes	3	4	8
123	R:R:H137	R:R:P135	10.68	No	No	0	5	7
124	R:R:L138	R:R:P135	6.57	No	No	3	4	7
125	R:R:L146	R:R:V142	4.47	No	No	0	6	7
126	R:R:L145	R:R:L149	4.15	No	No	0	4	5
127	R:R:G148	R:R:L151	5.13	No	No	0	4	3
128	R:R:F153	R:R:L149	3.65	No	No	0	4	5
129	R:R:F153	R:R:L152	3.65	No	No	0	4	4
130	R:R:F153	R:R:W183	18.04	No	Yes	0	4	5
131	R:R:M155	R:R:S154	4.6	No	No	0	4	6
132	R:R:L156	R:R:Y240	18.76	No	Yes	4	7	4
133	R:R:E157	R:R:Y240	3.37	No	Yes	0	5	4
134	R:R:E157	R:R:H243	3.69	No	No	0	5	2
135	R:R:F160	R:R:W158	6.01	No	No	0	4	3
136	R:R:R159	R:R:W172	11	No	Yes	7	3	1
137	R:R:E174	R:R:R159	8.14	No	No	7	2	3
138	R:R:D162	R:R:W172	13.4	No	Yes	0	2	1
139	R:R:F163	R:R:W172	4.01	No	Yes	0	4	1
140	R:R:E174	R:R:W172	13.08	No	Yes	7	2	1
141	R:R:C173	R:R:D177	6.22	No	No	0	3	4
142	R:R:D177	R:R:I179	5.6	No	No	0	4	5
143	R:R:F178	R:R:V181	10.49	No	No	0	4	4
144	R:R:F178	R:R:R241	23.52	No	No	0	4	3
145	R:R:I179	R:R:P180	5.08	No	No	0	5	5
146	R:R:P180	R:R:Y240	5.56	No	Yes	4	5	4
147	R:R:A237	R:R:V181	3.39	No	No	0	5	4
148	R:R:V181	R:R:Y240	5.05	No	Yes	0	4	4
149	R:R:F186	R:R:W183	7.02	No	Yes	0	5	5
150	R:R:L187	R:R:W183	12.53	No	Yes	0	8	5
151	R:R:F225	R:R:L191	17.05	Yes	No	0	9	8
152	R:R:L203	R:R:Y215	7.03	No	No	0	4	5
153	R:R:M209	R:R:R207	14.89	No	No	0	3	4
154	R:R:L211	R:R:Y215	9.38	No	No	0	6	5
155	R:R:R213	R:R:R279	10.66	No	No	0	7	7
156	R:R:I271	R:R:L220	5.71	No	No	0	8	6
157	R:R:I271	R:R:T221	4.56	No	No	2	8	7
158	R:R:T221	R:R:Y272	6.24	No	Yes	2	7	9
159	R:R:F225	R:R:L226	3.65	Yes	No	0	9	7
160	R:R:F225	R:R:L230	3.65	Yes	No	0	9	5
161	R:R:G229	R:R:N264	5.09	No	No	0	7	9
162	R:R:F232	R:R:Y254	7.22	No	Yes	0	6	3
163	R:R:F232	R:R:S261	9.25	No	No	0	6	8
164	R:R:L235	R:R:Y254	4.69	No	Yes	0	3	3
165	R:R:C257	R:R:L235	7.94	No	No	0	6	3
166	R:R:I239	R:R:Y250	3.63	No	Yes	0	4	3
167	R:R:R241	R:R:Y240	13.38	No	Yes	0	3	4
168	R:R:L244	R:R:Y250	7.03	No	Yes	0	1	3
169	R:R:E247	R:R:L249	9.28	No	No	0	1	1
170	R:R:V253	R:R:Y250	8.83	No	Yes	0	4	3
171	R:R:C251	R:R:H252	7.37	No	No	0	2	1
172	R:R:N268	R:R:Y272	6.98	Yes	Yes	2	9	9
173	R:R:F274	R:R:I270	3.77	Yes	No	0	7	6
174	R:R:I271	R:R:Y272	3.63	No	Yes	2	8	9
175	R:R:F274	R:R:S277	3.96	Yes	No	0	7	6
176	R:R:G276	R:R:V275	3.68	No	No	0	8	7
177	R:R:G276	R:R:R279	6	No	No	0	8	7
178	R:R:A71	R:R:T108	3.36	No	Yes	0	9	7
179	R:R:K208	R:R:P210	3.35	No	No	0	4	5
180	R:R:L260	R:R:P231	3.28	No	No	0	7	9
181	R:R:S117	R:R:S195	3.26	No	No	0	9	8
182	R:R:S195	R:R:V222	3.23	No	No	0	8	8
183	R:R:C188	R:R:L230	3.17	No	No	0	6	5
184	R:R:C228	R:R:L260	3.17	No	No	0	7	7
185	R:R:A70	R:R:L49	3.15	No	No	0	5	7
186	R:R:I37	R:R:S266	3.1	No	No	0	7	8
187	R:R:F107	R:R:W183	3.01	No	Yes	0	6	5
188	R:R:L76	R:R:S262	3	No	No	0	7	6
189	R:R:L187	R:R:S114	3	No	No	0	8	7
190	R:R:L28	R:R:V32	2.98	No	No	0	4	5
191	R:R:N59	R:R:S62	2.98	No	No	0	8	8
192	R:R:L196	R:R:V200	2.98	No	No	0	4	4
193	R:R:L249	R:R:V248	2.98	No	No	0	1	1
194	R:R:L260	R:R:V256	2.98	No	No	0	7	5
195	R:R:N264	R:R:V224	2.96	No	No	0	9	7
196	R:R:L28	R:R:T31	2.95	No	No	0	4	4
197	R:R:L122	R:R:T118	2.95	No	No	0	6	6
198	R:R:G53	R:R:Y54	2.9	No	No	0	5	5
199	R:R:I65	R:R:L52	2.85	No	No	0	8	7
200	R:R:I218	R:R:L198	2.85	No	No	0	8	8
201	R:R:I202	R:R:L203	2.85	No	No	0	7	4
202	R:R:I202	R:R:L214	2.85	No	No	0	7	7
203	R:R:I234	R:R:L230	2.85	No	No	0	6	5
204	R:R:L255	R:R:M258	2.83	No	No	0	3	4
205	R:R:C132	R:R:R133	2.79	No	No	0	5	4
206	R:R:L49	R:R:L66	2.77	No	No	0	7	7
207	R:R:H243	R:R:T175	2.74	No	No	0	2	4
208	R:R:N264	R:R:N268	2.72	No	Yes	0	9	9
209	R:R:F30	R:R:V256	2.62	No	No	0	5	5
210	R:R:F274	R:R:V48	2.62	Yes	Yes	0	7	9
211	R:R:R159	R:R:T175	2.59	No	No	0	3	4
212	R:R:I128	R:R:R133	2.51	No	No	0	6	4
213	R:R:F107	R:R:L184	2.44	No	No	0	6	7
214	R:R:L66	R:R:R58	2.43	No	No	0	7	6
215	R:R:L85	R:R:R95	2.43	No	Yes	0	4	7
216	R:R:L255	R:R:R86	2.43	No	No	0	3	3
217	R:R:I97	R:R:W158	2.35	No	No	0	4	3
218	R:R:L199	R:R:Y215	2.34	No	No	0	5	5
219	R:R:Q280	R:R:R279	2.34	No	No	0	6	7
220	R:R:L122	R:R:W126	2.28	No	No	0	6	5
221	R:R:L125	R:R:W126	2.28	No	No	0	7	5
222	R:R:E247	R:R:Y250	2.24	No	Yes	0	1	3
223	R:R:A71	R:R:G109	1.95	No	No	0	9	9
224	R:R:C35	R:R:P84	1.88	No	No	0	4	4
225	R:R:G44	R:R:V47	1.84	No	No	0	8	7
226	R:R:G44	R:R:T43	1.82	No	No	0	8	5
227	R:R:C188	R:R:C192	1.82	No	No	0	6	5
228	R:R:C204	R:R:V200	1.71	No	No	0	4	4
229	R:R:A69	R:R:V48	1.7	No	Yes	0	9	9
230	R:R:L87	R:R:P22	1.64	No	No	0	4	3
231	R:R:L211	R:R:P210	1.64	No	No	0	6	5
232	R:R:S194	R:R:V193	1.62	Yes	No	0	8	3
233	R:R:I97	R:R:V101	1.54	No	No	0	4	5
234	R:R:I202	R:R:V124	1.54	No	No	0	7	8
235	R:R:I218	R:R:T217	1.52	No	No	0	8	7
236	R:R:L33	R:R:V32	1.49	No	No	0	5	5
237	R:R:I80	R:R:L39	1.43	No	No	0	7	5
238	R:R:I81	R:R:L98	1.43	No	No	0	5	4
239	R:R:I94	R:R:L85	1.43	No	No	0	5	4
240	R:R:I94	R:R:L98	1.43	No	No	0	5	4
241	R:R:C132	R:R:R131	1.39	No	No	0	5	6
242	R:R:D162	R:R:M155	1.39	No	No	0	2	4
243	R:R:H137	R:R:V141	1.38	No	No	0	5	3
244	R:R:L223	R:R:L227	1.38	No	No	0	5	5
245	R:R:P127	R:R:W126	1.35	No	No	0	8	5
246	R:R:C23	R:R:Y24	1.34	No	No	0	2	3
247	R:R:R213	R:R:V216	1.31	No	No	0	7	6
248	R:R:R213	R:R:T212	1.29	No	No	0	7	5
249	R:R:I90	R:R:R95	1.25	No	Yes	0	3	7
250	R:R:N25	R:R:Y24	1.16	No	No	0	1	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.26	12	4	0
2	R:R:V48	3.2725	4	0	9
3	R:R:Y64	6.52833	6	0	8
4	R:R:D72	6.93	4	2	9
5	R:R:F75	6.405	4	0	6
6	R:R:F78	4.52	4	1	6
7	R:R:R82	6.00667	6	1	4
8	R:R:R95	5.08	4	0	7
9	R:R:M102	5.7075	4	1	4
10	R:R:F104	7.218	5	1	5
11	R:R:Y106	7.92	4	0	8
12	R:R:T108	7.68	4	1	7
13	R:R:L113	6.8225	4	2	9
14	R:R:Y130	9.474	5	3	7
15	R:R:R134	7.68	5	3	8
16	R:R:W147	7.73	4	1	9
17	R:R:W172	10.3725	4	7	1
18	R:R:W183	10.15	4	0	5
19	R:R:S194	3.6875	4	0	8
20	R:R:F225	8.036	5	0	9
21	R:R:Y240	9.14667	6	4	4
22	R:R:Y250	5.4325	4	0	3
23	R:R:Y254	6.8275	4	0	3
24	R:R:N268	7.132	5	2	9
25	R:R:Y272	6	5	2	9
26	R:R:F273	8.35	4	5	7
27	R:R:F274	3.57	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R95	32.991	12.38	Yes	Yes	0	0	7
2	R:R:R82	R:R:R95	36.219	4.26	Yes	Yes	0	4	7
3	R:R:Q79	R:R:R82	29.871	3.5	No	Yes	1	6	4
4	R:R:M258	R:R:Q79	56.2051	9.52	No	No	0	4	6
5	R:R:L255	R:R:M258	35.8406	2.83	No	No	0	3	4
6	L:L:?1	R:R:V99	30.8055	9.11	Yes	No	0	0	5
7	R:R:R82	R:R:V99	31.7167	6.54	Yes	No	0	4	5
8	L:L:?1	R:R:Y254	84.4003	7.17	Yes	Yes	0	0	3
9	R:R:R82	R:R:Y254	34.5741	8.23	Yes	Yes	0	4	3
10	R:R:F30	R:R:L255	25.3919	7.31	No	No	0	5	3
11	R:R:F30	R:R:Q26	14.0783	9.37	No	No	0	5	2
12	R:R:H252	R:R:Q26	11.7692	4.95	No	No	0	1	2
13	R:R:M258	R:R:T34	20.8665	9.03	No	No	0	4	7
14	R:R:L83	R:R:T34	16.3488	4.42	No	No	0	6	7
15	R:R:M102	R:R:R82	72.5925	7.44	Yes	Yes	1	4	4
16	R:R:F75	R:R:M102	81.5044	6.22	Yes	Yes	0	6	4
17	R:R:F75	R:R:S265	100	7.93	Yes	No	0	6	9
18	R:R:L76	R:R:S265	40.0263	6.01	No	No	0	7	9
19	R:R:L76	R:R:S262	36.775	3	No	No	0	7	6
20	R:R:I37	R:R:S262	16.9434	4.64	No	No	0	7	6
21	R:R:F232	R:R:Y254	59.1474	7.22	No	Yes	0	6	3
22	R:R:F232	R:R:Y106	45.8182	10.32	No	Yes	0	6	8
23	R:R:F75	R:R:Y106	27.1295	6.19	Yes	Yes	0	6	8
24	R:R:F232	R:R:S261	14.5494	9.25	No	No	0	6	8
25	R:R:F75	R:R:S261	15.2135	5.28	Yes	No	0	6	8
26	R:R:S262	R:R:S38	16.9434	4.89	No	No	0	6	5
27	R:R:I80	R:R:S38	13.5841	4.64	No	No	0	7	5
28	R:R:I37	R:R:S266	10.2093	3.1	No	No	0	7	8
29	R:R:D72	R:R:S265	80.4232	8.83	Yes	No	0	9	9
30	R:R:D72	R:R:N45	53.9501	6.73	Yes	No	0	9	9
31	R:R:N45	R:R:P269	50.8997	11.4	No	No	0	9	9
32	R:R:P269	R:R:V48	47.8338	3.53	No	Yes	0	9	9
33	R:R:F274	R:R:V48	19.5459	2.62	Yes	Yes	0	7	9
34	R:R:F273	R:R:V48	22.7508	5.24	Yes	Yes	0	7	9
35	R:R:L110	R:R:Y106	43.9339	9.38	No	Yes	0	7	8
36	R:R:F225	R:R:L110	43.625	9.74	Yes	No	0	9	7
37	R:R:F225	R:R:L113	41.926	6.09	Yes	Yes	0	9	9
38	R:R:L113	R:R:Y272	29.176	4.69	Yes	Yes	2	9	9
39	R:R:I116	R:R:Y272	57.6261	8.46	No	Yes	0	8	9
40	R:R:I116	R:R:Y64	46.1966	3.63	No	Yes	0	8	8
41	R:R:S139	R:R:Y64	16.3642	6.36	No	Yes	0	9	8
42	R:R:I63	R:R:S139	14.7965	9.29	No	No	0	7	9
43	R:R:I63	R:R:R58	13.2134	5.01	No	No	0	7	6
44	R:R:E119	R:R:Y64	29.1065	11.22	No	Yes	0	8	8
45	R:R:E119	R:R:Y130	12.4102	12.35	No	Yes	3	8	7
46	R:R:F78	R:R:M102	38.976	3.73	Yes	Yes	1	6	4
47	R:R:F78	R:R:P105	27.6006	4.33	Yes	No	1	6	8
48	R:R:F104	R:R:P105	26.5966	7.22	Yes	No	1	5	8
49	R:R:F104	R:R:W147	15.0514	6.01	Yes	Yes	1	5	9
50	R:R:M112	R:R:W147	12.1168	3.49	No	Yes	1	7	9
51	R:R:L146	R:R:M112	12.7655	4.24	No	No	0	6	7
52	R:R:L146	R:R:V142	11.4217	4.47	No	No	0	6	7
53	R:R:V142	R:R:Y64	11.1592	8.83	No	Yes	0	7	8
54	R:R:D72	R:R:N268	44.5826	6.73	Yes	Yes	2	9	9
55	R:R:F78	R:R:V101	11.36	3.93	Yes	No	0	6	5
56	L:L:?1	R:R:F107	39.6401	5.79	Yes	No	0	0	6
57	R:R:F107	R:R:W183	32.7284	3.01	No	Yes	0	6	5
58	R:R:L187	R:R:W183	11.0433	12.53	No	Yes	0	8	5
59	R:R:F225	R:R:L191	28.8594	17.05	Yes	No	0	9	8
60	R:R:L191	R:R:S117	26.8978	6.01	No	No	0	8	9
61	R:R:S117	R:R:S194	20.9205	4.89	No	Yes	0	9	8
62	R:R:I116	R:R:R120	20.4108	3.76	No	No	0	8	9
63	R:R:I218	R:R:R120	19.0208	3.76	No	No	0	8	9
64	R:R:I218	R:R:L198	16.0707	2.85	No	No	0	8	8
65	R:R:L198	R:R:V124	14.6652	5.96	No	No	0	8	8
66	R:R:E119	R:R:R134	15.3989	5.82	No	Yes	3	8	8
67	R:R:R133	R:R:W129	12.8736	9	No	No	0	4	4
68	R:R:F153	R:R:W183	14.6961	18.04	No	Yes	0	4	5
69	L:L:?1	R:R:Y240	55.2475	8.76	Yes	Yes	4	0	4
70	R:R:E157	R:R:Y240	34.8984	3.37	No	Yes	0	5	4
71	R:R:E157	R:R:H243	31.3383	3.69	No	No	0	5	2
72	R:R:H243	R:R:T175	27.7241	2.74	No	No	0	2	4
73	R:R:R159	R:R:T175	24.3571	2.59	No	No	0	3	4
74	R:R:R159	R:R:W172	17.3064	11	No	Yes	7	3	1
75	R:R:D162	R:R:W172	10.5182	13.4	No	Yes	0	2	1
76	L:L:?1	R:R:P180	13.7771	6.69	Yes	No	4	0	5
77	R:R:I179	R:R:P180	10.7962	5.08	No	No	0	5	5
78	R:R:V181	R:R:Y240	10.773	5.05	No	Yes	0	4	4
79	R:R:I202	R:R:V124	13.0744	1.54	No	No	0	7	8
80	R:R:I202	R:R:L203	10.0239	2.85	No	No	0	7	4
81	R:R:N264	R:R:N268	10.4873	2.72	No	Yes	0	9	9
82	L:L:?1	R:R:I239	25.3688	7.76	Yes	No	0	0	4
83	R:R:I239	R:R:Y250	21.7623	3.63	No	Yes	0	4	3
84	R:R:E247	R:R:Y250	11.0433	2.24	No	Yes	0	1	3
85	R:R:N268	R:R:Y272	31.4542	6.98	Yes	Yes	2	9	9
86	R:R:M102	R:R:Q79	28.3342	5.44	Yes	No	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R95	12.38	4	Yes	Yes	0	7	0	1
L:L:?1	R:R:K96	8.62	4	Yes	No	0	5	0	1
L:L:?1	R:R:V99	9.11	4	Yes	No	0	5	0	1
L:L:?1	R:R:T103	5.01	4	Yes	No	0	4	0	1
L:L:?1	R:R:F107	5.79	4	Yes	No	0	6	0	1
L:L:?1	R:R:L156	31.97	4	Yes	No	0	7	0	1
L:L:?1	R:R:P180	6.69	4	Yes	No	0	5	0	1
L:L:?1	R:R:G236	10.46	4	Yes	No	0	4	0	1
L:L:?1	R:R:I239	7.76	4	Yes	No	0	4	0	1
L:L:?1	R:R:Y240	8.76	4	Yes	Yes	0	4	0	1
L:L:?1	R:R:L246	9.4	4	Yes	No	0	1	0	1
L:L:?1	R:R:Y254	7.17	4	Yes	Yes	0	3	0	1
R:R:R82	R:R:R95	4.26	1	Yes	Yes	4	7	2	1
R:R:R82	R:R:V99	6.54	1	Yes	No	4	5	2	1
R:R:R82	R:R:Y254	8.23	1	Yes	Yes	4	3	2	1
R:R:L156	R:R:Y240	18.76	4	No	Yes	7	4	1	1
R:R:E157	R:R:Y240	3.37	0	No	Yes	5	4	2	1
R:R:I179	R:R:P180	5.08	0	No	No	5	5	2	1
R:R:P180	R:R:Y240	5.56	4	No	Yes	5	4	1	1
R:R:V181	R:R:Y240	5.05	0	No	Yes	4	4	2	1
R:R:F232	R:R:Y254	7.22	0	No	Yes	6	3	2	1
R:R:L235	R:R:Y254	4.69	0	No	Yes	3	3	2	1
R:R:I239	R:R:Y250	3.63	0	No	Yes	4	3	1	2
R:R:R241	R:R:Y240	13.38	0	No	Yes	3	4	2	1
R:R:F107	R:R:W183	3.01	0	No	Yes	6	5	1	2
R:R:F107	R:R:L184	2.44	0	No	No	6	7	1	2
R:R:L85	R:R:R95	2.43	0	No	Yes	4	7	2	1
R:R:I90	R:R:R95	1.25	0	No	Yes	3	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8K4S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.37
Number of Linked Nodes	230
Number of Links	250
Number of Hubs	27
Number of Links mediated by Hubs	108
Number of Communities	7
Number of Nodes involved in Communities	38
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	36704
Length Of Smallest Path	3
Average Path Length	11.9566
Length of Longest Path	28
Minimum Path Strength	1.25
Average Path Strength	6.51127
Maximum Path Strength	22.175
Minimum Path Correlation	0.7
Average Path Correlation	0.928144
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	53.6211
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.0546
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled bile acid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • bioluminescence • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • bioluminescence • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception • nervous system process • sensory perception of itch • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane • protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • protein binding • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JW0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JW0
Name	(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Synonyms
Identifier
Formula	C24 H41 O7 P
Molecular Weight	472.552
SMILES
PubChem	172408416
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	10
Total Bonds	76
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LA9
Sequence	>8K4S_nogp_Chain_R P C Y N Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M R R N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L I N I S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W P I W Y R C R R P T H L S A V V C V L L W G L S L L F S M L E W R F C D F L F S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C G S R K M P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L I Y R M H L N L E V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7S8P	A	Orphan	Orphan	MRGPRX4	Homo sapiens	MS47134	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	7S8P (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	MS47134	-		2.6	2021-11-17	doi.org/10.1038/s41586-021-04126-6
	8YRG	A	Orphan	Orphan	MRGPRX4	Homo sapiens	Fospropofol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2024-05-22	doi.org/10.1126/scitranslmed.adk8198
	8YRG (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	Fospropofol	-		3.14	2024-05-22	doi.org/10.1126/scitranslmed.adk8198
	8K4S	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.9	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8K4S (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-		2.9	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8KEX	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-	-	3.2	2024-11-06	doi.org/10.1016/j.cell.2024.10.001

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.