psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R82	8.24	Yes	Yes	1	0	4
2	L:L:?1	R:R:R86	8.24	Yes	No	1	0	3
3	L:L:?1	R:R:H92	4.36	Yes	No	0	0	6
4	L:L:?1	R:R:R95	7.55	Yes	Yes	1	0	7
5	L:L:?1	R:R:K96	15.93	Yes	No	0	0	5
6	L:L:?1	R:R:Y250	22.52	Yes	No	1	0	3
7	L:L:?1	R:R:Y254	5.3	Yes	Yes	1	0	3
8	R:R:R86	R:R:T27	16.82	No	No	0	3	2
9	R:R:L255	R:R:T27	5.9	No	No	0	3	2
10	R:R:F30	R:R:T31	3.89	Yes	No	0	5	4
11	R:R:F30	R:R:T34	15.56	Yes	Yes	1	5	7
12	R:R:F30	R:R:L255	17.05	Yes	No	0	5	3
13	R:R:F30	R:R:M258	7.46	Yes	Yes	1	5	4
14	R:R:F30	R:R:S259	6.61	Yes	No	1	5	5
15	R:R:Q79	R:R:T34	4.25	Yes	Yes	1	6	7
16	R:R:S259	R:R:T34	3.2	No	Yes	1	5	7
17	R:R:S262	R:R:T34	4.8	No	Yes	0	6	7
18	R:R:C35	R:R:S83	5.16	No	No	0	4	6
19	R:R:I37	R:R:S262	3.1	Yes	No	0	7	6
20	R:R:I37	R:R:S266	3.1	Yes	No	0	7	8
21	R:R:L76	R:R:S38	4.5	No	No	0	7	5
22	R:R:S262	R:R:S38	3.26	No	No	0	6	5
23	R:R:G41	R:R:S266	3.71	No	No	0	9	8
24	R:R:F73	R:R:L42	7.31	No	No	0	6	6
25	R:R:G44	R:R:V47	3.68	No	No	0	8	7
26	R:R:D72	R:R:N45	13.46	Yes	No	0	9	9
27	R:R:N45	R:R:P269	14.66	No	No	0	9	9
28	R:R:L51	R:R:V47	2.98	Yes	No	0	7	7
29	R:R:L52	R:R:V48	2.98	Yes	Yes	0	7	9
30	R:R:A69	R:R:V48	3.39	No	Yes	0	9	9
31	R:R:P269	R:R:V48	5.3	No	Yes	0	9	9
32	R:R:L49	R:R:L66	4.15	No	No	0	7	7
33	R:R:W50	R:R:Y54	5.79	No	No	0	5	5
34	R:R:L51	R:R:R55	8.5	Yes	No	0	7	5
35	R:R:F273	R:R:L51	6.09	No	Yes	0	7	7
36	R:R:L52	R:R:S62	3	Yes	No	0	7	8
37	R:R:L52	R:R:L66	4.15	Yes	No	0	7	7
38	R:R:F273	R:R:L52	6.09	No	Yes	0	7	7
39	R:R:R58	R:R:T136	3.88	No	No	0	6	5
40	R:R:N59	R:R:S62	7.45	No	No	0	8	8
41	R:R:A60	R:R:Y130	4	No	Yes	4	7	7
42	R:R:A60	R:R:R134	5.53	No	Yes	4	7	8
43	R:R:I65	R:R:V61	3.07	No	No	0	8	7
44	R:R:I63	R:R:S139	7.74	No	No	0	7	9
45	R:R:I116	R:R:Y64	4.84	No	Yes	0	8	8
46	R:R:E119	R:R:Y64	8.98	No	Yes	0	8	8
47	R:R:S139	R:R:Y64	5.09	No	Yes	0	9	8
48	R:R:V142	R:R:Y64	8.83	No	Yes	0	7	8
49	R:R:C143	R:R:Y64	2.69	Yes	Yes	0	7	8
50	R:R:M112	R:R:N67	5.61	No	No	5	7	9
51	R:R:C143	R:R:N67	4.72	Yes	No	5	7	9
52	R:R:N67	R:R:W147	4.52	No	No	0	9	9
53	R:R:D72	R:R:L68	2.71	Yes	No	3	9	9
54	R:R:L113	R:R:L68	5.54	No	No	3	9	9
55	R:R:L68	R:R:N268	4.12	No	Yes	3	9	9
56	R:R:A71	R:R:T108	3.36	No	Yes	0	9	7
57	R:R:D72	R:R:S265	11.78	Yes	No	0	9	9
58	R:R:D72	R:R:N268	6.73	Yes	Yes	3	9	9
59	R:R:L74	R:R:S77	3	No	No	0	6	5
60	R:R:L74	R:R:P105	9.85	No	No	0	6	8
61	R:R:F75	R:R:Y106	9.28	No	No	1	6	8
62	R:R:F232	R:R:F75	4.29	Yes	No	1	6	6
63	R:R:F75	R:R:S261	5.28	No	No	1	6	8
64	R:R:L76	R:R:S265	10.51	No	No	0	7	9
65	R:R:F78	R:R:I81	3.77	No	No	0	6	5
66	R:R:F78	R:R:V101	6.55	No	No	0	6	5
67	R:R:F78	R:R:M102	6.22	No	Yes	0	6	4
68	R:R:Q79	R:R:R82	5.84	Yes	Yes	1	6	4
69	R:R:M102	R:R:Q79	4.08	Yes	Yes	1	4	6
70	R:R:M258	R:R:Q79	13.59	Yes	Yes	1	4	6
71	R:R:I81	R:R:L98	2.85	No	No	0	5	4
72	R:R:L98	R:R:R82	14.58	No	Yes	0	4	4
73	R:R:R82	R:R:V99	5.23	Yes	No	0	4	5
74	R:R:M102	R:R:R82	8.69	Yes	Yes	1	4	4
75	R:R:P84	R:R:S83	7.13	No	No	0	4	6
76	R:R:I90	R:R:L85	14.27	No	No	1	3	4
77	R:R:L85	R:R:R95	3.64	No	Yes	1	4	7
78	R:R:R86	R:R:Y250	7.2	No	No	1	3	3
79	R:R:I90	R:R:I94	7.36	No	No	0	3	5
80	R:R:I90	R:R:R95	6.26	No	Yes	1	3	7
81	R:R:I94	R:R:S91	4.64	No	No	0	5	3
82	R:R:V99	R:R:W158	6.13	No	Yes	0	5	3
83	R:R:E157	R:R:S100	10.06	Yes	No	1	5	4
84	R:R:F160	R:R:S100	10.57	No	No	1	4	4
85	R:R:M102	R:R:M258	2.89	Yes	Yes	1	4	4
86	R:R:E157	R:R:T103	9.88	Yes	No	1	5	4
87	R:R:T103	R:R:W158	4.85	No	Yes	1	4	3
88	R:R:F104	R:R:P105	8.67	No	No	0	5	8
89	R:R:F104	R:R:S150	3.96	No	No	0	5	8
90	R:R:L110	R:R:Y106	12.89	No	No	0	7	8
91	R:R:F232	R:R:Y106	23.73	Yes	No	1	6	8
92	R:R:F107	R:R:S154	7.93	No	No	0	6	6
93	R:R:F107	R:R:L184	6.09	No	Yes	0	6	7
94	R:R:G109	R:R:T108	3.64	No	Yes	0	9	7
95	R:R:T108	R:R:W147	12.13	Yes	No	0	7	9
96	R:R:S150	R:R:T108	4.8	No	Yes	0	8	7
97	R:R:L146	R:R:S111	6.01	No	No	0	6	7
98	R:R:S111	R:R:W183	3.71	No	Yes	0	7	5
99	R:R:C143	R:R:M112	3.24	Yes	No	5	7	7
100	R:R:L113	R:R:N268	8.24	No	Yes	3	9	9
101	R:R:L113	R:R:Y272	7.03	No	Yes	0	9	9
102	R:R:L187	R:R:S114	3	No	No	0	8	7
103	R:R:S114	R:R:V190	4.85	No	No	0	7	6
104	R:R:I116	R:R:Y272	3.63	No	Yes	0	8	9
105	R:R:L191	R:R:S117	6.01	No	No	0	8	9
106	R:R:S117	R:R:S194	4.89	No	No	0	9	8
107	R:R:S194	R:R:T118	6.4	No	No	0	8	6
108	R:R:E119	R:R:Y130	6.73	No	Yes	0	8	7
109	R:R:L198	R:R:R120	3.64	No	No	0	8	9
110	R:R:C121	R:R:L125	3.17	No	Yes	6	7	7
111	R:R:C121	R:R:V197	3.42	No	No	6	7	5
112	R:R:S123	R:R:Y130	11.45	No	Yes	0	8	7
113	R:R:L198	R:R:V124	7.45	No	No	0	8	8
114	R:R:I202	R:R:V124	3.07	No	No	0	7	8
115	R:R:L125	R:R:V197	4.47	Yes	No	6	7	5
116	R:R:L125	R:R:R201	8.5	Yes	No	0	7	6
117	R:R:W129	R:R:Y130	5.79	No	Yes	4	4	7
118	R:R:R134	R:R:W129	5	Yes	No	4	8	4
119	R:R:R134	R:R:Y130	3.09	Yes	Yes	4	8	7
120	R:R:P135	R:R:R134	4.32	No	Yes	0	7	8
121	R:R:L138	R:R:P135	8.21	No	No	0	4	7
122	R:R:L138	R:R:V142	2.98	No	No	0	4	7
123	R:R:F153	R:R:L149	7.31	No	No	0	4	5
124	R:R:L149	R:R:W183	11.39	No	Yes	0	5	5
125	R:R:L151	R:R:L152	2.77	No	No	0	3	4
126	R:R:E157	R:R:W158	3.27	Yes	Yes	1	5	3
127	R:R:E157	R:R:F160	3.5	Yes	No	1	5	4
128	R:R:L235	R:R:W158	6.83	Yes	Yes	1	3	3
129	R:R:G236	R:R:W158	8.44	No	Yes	1	4	3
130	R:R:I239	R:R:W158	11.74	Yes	Yes	1	4	3
131	R:R:W158	R:R:Y254	4.82	Yes	Yes	1	3	3
132	R:R:D177	R:R:R159	10.72	Yes	No	2	4	3
133	R:R:R159	R:R:Y240	15.43	No	No	0	3	4
134	R:R:R159	R:R:R241	8.53	No	Yes	2	3	3
135	R:R:D177	R:R:T175	2.89	Yes	No	2	4	4
136	R:R:R241	R:R:T175	6.47	Yes	No	2	3	4
137	R:R:D177	R:R:F178	8.36	Yes	No	2	4	4
138	R:R:D177	R:R:R241	16.68	Yes	Yes	2	4	3
139	R:R:F178	R:R:R241	8.55	No	Yes	2	4	3
140	R:R:I179	R:R:P180	5.08	No	No	0	5	5
141	R:R:L187	R:R:W183	12.53	No	Yes	0	8	5
142	R:R:L184	R:R:L230	4.15	Yes	No	0	7	5
143	R:R:F186	R:R:L187	3.65	No	No	0	5	8
144	R:R:F186	R:R:V190	6.55	No	No	0	5	6
145	R:R:C188	R:R:F225	4.19	Yes	No	0	6	9
146	R:R:C188	R:R:L230	3.17	Yes	No	0	6	5
147	R:R:L191	R:R:V222	2.98	No	Yes	0	8	8
148	R:R:F225	R:R:L191	15.83	No	No	0	9	8
149	R:R:I218	R:R:S195	4.64	Yes	No	0	8	8
150	R:R:S195	R:R:V222	3.23	No	Yes	0	8	8
151	R:R:I218	R:R:L198	2.85	Yes	No	0	8	8
152	R:R:L199	R:R:Y215	4.69	No	No	0	5	5
153	R:R:I202	R:R:K208	11.63	No	No	0	7	4
154	R:R:I202	R:R:L214	4.28	No	No	0	7	7
155	R:R:L203	R:R:Y215	3.52	No	No	0	4	5
156	R:R:G205	R:R:K208	3.49	No	No	0	5	4
157	R:R:K208	R:R:L211	7.05	No	No	0	4	6
158	R:R:M209	R:R:P210	5.03	No	No	0	3	5
159	R:R:L211	R:R:Y215	10.55	No	No	0	6	5
160	R:R:I218	R:R:L214	4.28	Yes	No	0	8	7
161	R:R:L219	R:R:L223	2.77	No	No	7	4	5
162	R:R:L220	R:R:V224	2.98	No	No	0	6	7
163	R:R:I271	R:R:L220	8.56	No	No	0	8	6
164	R:R:T221	R:R:Y272	6.24	No	Yes	0	7	9
165	R:R:G229	R:R:N264	3.39	No	No	0	7	9
166	R:R:I234	R:R:L230	8.56	No	No	0	6	5
167	R:R:C257	R:R:P231	3.77	No	No	0	6	9
168	R:R:F232	R:R:M258	3.73	Yes	Yes	1	6	4
169	R:R:F232	R:R:S261	6.61	Yes	No	1	6	8
170	R:R:I239	R:R:L235	4.28	Yes	Yes	1	4	3
171	R:R:L235	R:R:V253	8.94	Yes	No	0	3	4
172	R:R:L235	R:R:Y254	3.52	Yes	Yes	1	3	3
173	R:R:C257	R:R:L235	4.76	No	Yes	0	6	3
174	R:R:G236	R:R:I239	3.53	No	Yes	1	4	4
175	R:R:I239	R:R:Y240	7.25	Yes	No	0	4	4
176	R:R:L244	R:R:M242	12.72	No	No	0	1	1
177	R:R:H243	R:R:L246	14.14	No	No	0	2	1
178	R:R:L244	R:R:N245	6.87	No	No	0	1	2
179	R:R:H252	R:R:V248	8.3	No	No	0	1	1
180	R:R:L249	R:R:V253	2.98	No	No	0	1	4
181	R:R:M258	R:R:Y254	5.99	Yes	Yes	1	4	3
182	R:R:L260	R:R:V256	2.98	No	No	0	7	5
183	R:R:M258	R:R:S261	3.07	Yes	No	1	4	8
184	R:R:N264	R:R:N268	9.54	No	Yes	0	9	9
185	R:R:F274	R:R:I270	10.05	No	No	0	7	6
186	R:R:I271	R:R:Y272	3.63	No	Yes	0	8	9
187	R:R:F273	R:R:F274	3.22	No	No	0	7	7
188	R:R:F107	R:R:S150	2.64	No	No	0	6	8
189	R:R:R213	R:R:V275	2.62	No	No	0	7	7
190	R:R:F160	R:R:I97	2.51	No	No	0	4	4
191	R:R:F153	R:R:I179	2.51	No	No	0	4	5
192	R:R:M209	R:R:R207	2.48	No	No	0	3	4
193	R:R:F104	R:R:L151	2.44	No	No	0	5	3
194	R:R:L122	R:R:Y130	2.34	No	Yes	0	6	7
195	R:R:L122	R:R:W126	2.28	No	No	0	6	5
196	R:R:L125	R:R:W126	2.28	Yes	No	0	7	5
197	R:R:L184	R:R:W183	2.28	Yes	Yes	0	7	5
198	R:R:R133	R:R:W129	2	No	No	0	4	4
199	R:R:G205	R:R:S206	1.86	No	No	0	5	6
200	R:R:G41	R:R:V40	1.84	No	No	0	9	5
201	R:R:G44	R:R:T43	1.82	No	No	0	8	5
202	R:R:A140	R:R:C143	1.81	No	Yes	0	4	7
203	R:R:C35	R:R:S38	1.72	No	No	0	4	5
204	R:R:G148	R:R:L151	1.71	No	No	0	4	3
205	R:R:G233	R:R:L184	1.71	No	Yes	0	8	7
206	R:R:C228	R:R:V224	1.71	No	No	0	7	7
207	R:R:A237	R:R:V181	1.7	No	No	0	5	4
208	R:R:C35	R:R:I80	1.64	No	No	0	4	7
209	R:R:C132	R:R:I128	1.64	No	No	0	5	6
210	R:R:L156	R:R:P180	1.64	No	No	0	7	5
211	R:R:C188	R:R:I185	1.64	Yes	No	0	6	4
212	R:R:A182	R:R:I179	1.62	No	No	0	4	5
213	R:R:S194	R:R:V193	1.62	No	No	0	8	3
214	R:R:V189	R:R:V193	1.6	No	No	0	4	3
215	R:R:C188	R:R:L226	1.59	Yes	No	0	6	7
216	R:R:A46	R:R:L42	1.58	No	No	0	6	6
217	R:R:A70	R:R:L49	1.58	No	No	0	5	7
218	R:R:A115	R:R:L146	1.58	No	No	0	7	6
219	R:R:I65	R:R:V48	1.54	No	Yes	0	8	9
220	R:R:I116	R:R:V61	1.54	No	No	0	8	7
221	R:R:I271	R:R:V275	1.54	No	No	0	8	7
222	R:R:M155	R:R:S154	1.53	No	No	0	4	6
223	R:R:I218	R:R:T217	1.52	Yes	No	0	8	7
224	R:R:L156	R:R:S176	1.5	No	No	0	7	4
225	R:R:L219	R:R:V222	1.49	No	Yes	7	4	8
226	R:R:L223	R:R:V222	1.49	No	Yes	7	5	8
227	R:R:N245	R:R:V248	1.48	No	No	0	2	1
228	R:R:L28	R:R:T27	1.47	No	No	0	4	2
229	R:R:I36	R:R:I37	1.47	No	Yes	0	4	7
230	R:R:C251	R:R:H252	1.47	No	No	0	2	1
231	R:R:I37	R:R:L263	1.43	Yes	No	0	7	5
232	R:R:I80	R:R:L39	1.43	No	No	0	7	5
233	R:R:L238	R:R:M242	1.41	No	No	0	5	1
234	R:R:C132	R:R:R133	1.39	No	No	0	5	4
235	R:R:L42	R:R:L76	1.38	No	No	0	6	7
236	R:R:L145	R:R:L149	1.38	No	No	0	4	5
237	R:R:P127	R:R:W126	1.35	No	No	0	8	5
238	R:R:C251	R:R:Y250	1.34	No	No	0	2	3
239	R:R:R213	R:R:T212	1.29	No	No	0	7	5
240	R:R:I63	R:R:R58	1.25	No	No	0	7	6
241	R:R:N89	R:R:R95	1.21	No	Yes	0	3	7
242	R:R:L51	R:R:W50	1.14	Yes	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.3057	7	1	0
2	R:R:F30	10.114	5	1	5
3	R:R:T34	6.9525	4	1	7
4	R:R:I37	2.275	4	0	7
5	R:R:V48	3.3025	4	0	9
6	R:R:L51	4.6775	4	0	7
7	R:R:L52	4.055	4	0	7
8	R:R:Y64	6.086	5	0	8
9	R:R:D72	8.67	4	3	9
10	R:R:Q79	6.94	4	1	6
11	R:R:R82	8.516	5	1	4
12	R:R:R95	4.665	4	1	7
13	R:R:M102	5.47	4	1	4
14	R:R:T108	5.9825	4	0	7
15	R:R:L125	4.605	4	6	7
16	R:R:Y130	5.56667	6	4	7
17	R:R:R134	4.485	4	4	8
18	R:R:C143	3.115	4	5	7
19	R:R:E157	6.6775	4	1	5
20	R:R:W158	6.58286	7	1	3
21	R:R:D177	9.6625	4	2	4
22	R:R:W183	7.4775	4	0	5
23	R:R:L184	3.5575	4	0	7
24	R:R:C188	2.6475	4	0	6
25	R:R:I218	3.3225	4	0	8
26	R:R:V222	2.2975	4	7	8
27	R:R:F232	9.59	4	1	6
28	R:R:L235	5.666	5	1	3
29	R:R:I239	6.7	4	1	4
30	R:R:R241	10.0575	4	2	3
31	R:R:Y254	4.9075	4	1	3
32	R:R:M258	6.12167	6	1	4
33	R:R:N268	7.1575	4	3	9
34	R:R:Y272	5.1325	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M258	R:R:Y254	47.3951	5.99	Yes	Yes	1	4	3
2	R:R:F30	R:R:M258	28.8622	7.46	Yes	Yes	1	5	4
3	L:L:?1	R:R:R82	14.2276	8.24	Yes	Yes	1	0	4
4	R:R:Q79	R:R:R82	28.7416	5.84	Yes	Yes	1	6	4
5	R:R:Q79	R:R:T34	60.4619	4.25	Yes	Yes	1	6	7
6	R:R:S262	R:R:T34	94.1389	4.8	No	Yes	0	6	7
7	R:R:S262	R:R:S38	96.6504	3.26	No	No	0	6	5
8	R:R:L76	R:R:S38	98.5679	4.5	No	No	0	7	5
9	R:R:L76	R:R:S265	99.7256	10.51	No	No	0	7	9
10	R:R:D72	R:R:S265	100	11.78	Yes	No	0	9	9
11	R:R:D72	R:R:N45	10.6217	13.46	Yes	No	0	9	9
12	R:R:L52	R:R:V48	12.4849	2.98	Yes	Yes	0	7	9
13	R:R:D72	R:R:L68	45.36	2.71	Yes	No	3	9	9
14	R:R:L113	R:R:L68	45.1731	5.54	No	No	3	9	9
15	R:R:L113	R:R:Y272	90.325	7.03	No	Yes	0	9	9
16	R:R:I116	R:R:Y272	85.5644	3.63	No	Yes	0	8	9
17	R:R:I116	R:R:Y64	89.71	4.84	No	Yes	0	8	8
18	R:R:D72	R:R:N268	46.367	6.73	Yes	Yes	3	9	9
19	R:R:L113	R:R:N268	45.8062	8.24	No	Yes	3	9	9
20	R:R:E119	R:R:Y64	18.5932	8.98	No	Yes	0	8	8
21	R:R:E119	R:R:Y130	17.6495	6.73	No	Yes	0	8	7
22	R:R:C143	R:R:Y64	71.9459	2.69	Yes	Yes	0	7	8
23	R:R:C143	R:R:N67	69.1269	4.72	Yes	No	5	7	9
24	R:R:N67	R:R:W147	68.4364	4.52	No	No	0	9	9
25	R:R:T108	R:R:W147	67.544	12.13	Yes	No	0	7	9
26	R:R:S150	R:R:T108	64.8306	4.8	No	Yes	0	8	7
27	R:R:W158	R:R:Y254	24.9096	4.82	Yes	Yes	1	3	3
28	R:R:F107	R:R:S150	57.3293	2.64	No	No	0	6	8
29	R:R:F107	R:R:L184	54.4169	6.09	No	Yes	0	6	7
30	R:R:L184	R:R:W183	20.7911	2.28	Yes	Yes	0	7	5
31	R:R:L184	R:R:L230	34.6961	4.15	Yes	No	0	7	5
32	R:R:C188	R:R:L230	32.4952	3.17	Yes	No	0	6	5
33	R:R:C188	R:R:F225	29.1486	4.19	Yes	No	0	6	9
34	R:R:F225	R:R:L191	28.021	15.83	No	No	0	9	8
35	R:R:L191	R:R:V222	21.1288	2.98	No	Yes	0	8	8
36	R:R:S195	R:R:V222	17.5862	3.23	No	Yes	0	8	8
37	R:R:I218	R:R:S195	16.3893	4.64	Yes	No	0	8	8
38	R:R:I218	R:R:L214	10.7935	4.28	Yes	No	0	8	7
39	R:R:L235	R:R:Y254	22.3679	3.52	Yes	Yes	1	3	3
40	R:R:I239	R:R:L235	14.4808	4.28	Yes	Yes	1	4	3
41	R:R:I239	R:R:Y240	31.5967	7.25	Yes	No	0	4	4
42	R:R:R159	R:R:Y240	27.5024	15.43	No	No	0	3	4
43	R:R:D177	R:R:R159	12.0297	10.72	Yes	No	2	4	3
44	R:R:I239	R:R:W158	20.96	11.74	Yes	Yes	1	4	3
45	R:R:R159	R:R:R241	11.5865	8.53	No	Yes	2	3	3
46	R:R:F30	R:R:T34	32.6881	15.56	Yes	Yes	1	5	7
47	R:R:M258	R:R:Q79	28.2984	13.59	Yes	Yes	1	4	6
48	R:R:V99	R:R:W158	12.2678	6.13	No	Yes	0	5	3
49	R:R:R82	R:R:V99	13.0065	5.23	Yes	No	0	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R82	8.24	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R86	8.24	1	Yes	No	0	3	0	1
L:L:?1	R:R:H92	4.36	1	Yes	No	0	6	0	1
L:L:?1	R:R:R95	7.55	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:K96	15.93	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y250	22.52	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y254	5.3	1	Yes	Yes	0	3	0	1
R:R:R86	R:R:T27	16.82	1	No	No	3	2	1	2
R:R:Q79	R:R:R82	5.84	1	Yes	Yes	6	4	2	1
R:R:M102	R:R:Q79	4.08	1	Yes	Yes	4	6	2	2
R:R:M258	R:R:Q79	13.59	1	Yes	Yes	4	6	2	2
R:R:L98	R:R:R82	14.58	0	No	Yes	4	4	2	1
R:R:R82	R:R:V99	5.23	1	Yes	No	4	5	1	2
R:R:M102	R:R:R82	8.69	1	Yes	Yes	4	4	2	1
R:R:I90	R:R:L85	14.27	1	No	No	3	4	2	2
R:R:L85	R:R:R95	3.64	1	No	Yes	4	7	2	1
R:R:R86	R:R:Y250	7.2	1	No	No	3	3	1	1
R:R:I90	R:R:R95	6.26	1	No	Yes	3	7	2	1
R:R:V99	R:R:W158	6.13	0	No	Yes	5	3	2	2
R:R:M102	R:R:M258	2.89	1	Yes	Yes	4	4	2	2
R:R:L235	R:R:W158	6.83	1	Yes	Yes	3	3	2	2
R:R:W158	R:R:Y254	4.82	1	Yes	Yes	3	3	2	1
R:R:L235	R:R:Y254	3.52	1	Yes	Yes	3	3	2	1
R:R:M258	R:R:Y254	5.99	1	Yes	Yes	4	3	2	1
R:R:C251	R:R:Y250	1.34	0	No	No	2	3	2	1
R:R:N89	R:R:R95	1.21	0	No	Yes	3	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YRG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	215
Number of Links	242
Number of Hubs	34
Number of Links mediated by Hubs	125
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	50
Number Of Links MetaPath	49
Number of Shortest Paths	46228
Length Of Smallest Path	3
Average Path Length	19.5348
Length of Longest Path	42
Minimum Path Strength	1.405
Average Path Strength	6.19737
Maximum Path Strength	19.225
Minimum Path Correlation	0.7
Average Path Correlation	0.921494
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	36.8185
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.9523
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LA9
Sequence	>8YRG_nogp_Chain_R Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M R R N A V S I Y I L N L A A A D F L F L S F Q I I R P L R L I N I S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W P I W Y R C R R P T H L S A V V C V L L W G L S L L F S M L E W R F T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C G S R K M P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L I Y R M H L N L E V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8KEX	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-	-	3.2	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8K4S	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.9	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8K4S (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	DCA-3P	-		2.9	2024-11-06	doi.org/10.1016/j.cell.2024.10.001
	8YRG	A	Orphan	Orphan	MRGPRX4	Homo sapiens	Fospropofol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2024-05-22	10.1126/scitranslmed.adk8198
	8YRG (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	Fospropofol	-		3.14	2024-05-22	10.1126/scitranslmed.adk8198
	7S8P	A	Orphan	Orphan	MRGPRX4	Homo sapiens	MS47134	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2021-11-17	10.1038/s41586-021-04126-6
	7S8P (No Gprot)	A	Orphan	Orphan	MRGPRX4	Homo sapiens	MS47134	-		2.6	2021-11-17	10.1038/s41586-021-04126-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YRG_nogp.zip

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