psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:G108	8.6	Yes	No	0	0	4
2	L:L:?1	R:R:V111	11.24	Yes	No	0	0	7
3	L:L:?1	R:R:I112	8.38	Yes	Yes	1	0	6
4	L:L:?1	R:R:N162	3.45	Yes	No	0	0	4
5	L:L:?1	R:R:T178	3.71	Yes	No	1	0	4
6	L:L:?1	R:R:F179	24.51	Yes	Yes	0	0	4
7	L:L:?1	R:R:Q181	4.46	Yes	No	1	0	3
8	L:L:?1	R:R:V191	8.74	Yes	No	0	0	5
9	L:L:?1	R:R:L254	5.8	Yes	Yes	1	0	6
10	L:L:?1	R:R:N255	4.6	Yes	No	0	0	7
11	L:L:?1	R:R:Y281	2.95	Yes	Yes	1	0	5
12	R:R:L26	R:R:P23	4.93	No	No	0	2	2
13	R:R:L30	R:R:V278	4.47	No	Yes	1	5	4
14	R:R:L30	R:R:Y282	18.76	No	Yes	1	5	5
15	R:R:L34	R:R:Y282	5.86	No	Yes	0	7	5
16	R:R:I35	R:R:L85	4.28	No	No	0	4	6
17	R:R:F286	R:R:F36	5.36	No	No	0	4	4
18	R:R:F286	R:R:T37	5.19	No	No	2	4	6
19	R:R:C289	R:R:T37	6.76	Yes	No	2	7	6
20	R:R:I38	R:R:Y81	6.04	No	Yes	0	6	7
21	R:R:C289	R:R:V40	3.42	Yes	No	0	7	5
22	R:R:I293	R:R:V40	4.61	No	No	0	6	5
23	R:R:D41	R:R:N45	10.77	Yes	Yes	2	7	9
24	R:R:D41	R:R:D73	5.32	Yes	Yes	2	7	9
25	R:R:A77	R:R:D41	4.63	No	Yes	0	6	7
26	R:R:C289	R:R:D41	4.67	Yes	Yes	2	7	7
27	R:R:A77	R:R:I42	3.25	No	No	0	6	6
28	R:R:G44	R:R:L43	3.42	No	No	0	7	3
29	R:R:A70	R:R:N45	4.69	No	Yes	0	9	9
30	R:R:D73	R:R:N45	4.04	Yes	Yes	2	9	9
31	R:R:L74	R:R:N45	9.61	No	Yes	0	7	9
32	R:R:A292	R:R:N45	3.13	No	Yes	0	9	9
33	R:R:L47	R:R:Y306	7.03	No	Yes	0	6	6
34	R:R:V48	R:R:Y306	3.79	No	Yes	0	8	6
35	R:R:I49	R:R:Y53	20.55	No	No	0	7	3
36	R:R:I309	R:R:L50	5.71	Yes	No	0	6	4
37	R:R:F302	R:R:S51	6.61	Yes	No	3	8	8
38	R:R:E305	R:R:S51	10.06	No	No	3	6	8
39	R:R:I309	R:R:S51	3.1	Yes	No	3	6	8
40	R:R:V52	R:R:V67	4.81	No	No	0	7	6
41	R:R:I309	R:R:R54	5.01	Yes	No	0	6	4
42	R:R:R54	R:R:S312	7.91	No	No	0	4	5
43	R:R:K57	R:R:N55	8.39	No	No	0	5	5
44	R:R:L58	R:R:N55	13.73	No	No	0	8	5
45	R:R:K56	R:R:R59	9.9	No	No	0	6	7
46	R:R:L58	R:R:N63	4.12	No	No	3	8	8
47	R:R:F302	R:R:L58	8.53	Yes	No	3	8	8
48	R:R:G62	R:R:N60	3.39	No	No	0	7	7
49	R:R:G62	R:R:N124	5.09	No	Yes	0	7	8
50	R:R:F302	R:R:N63	4.83	Yes	No	3	8	8
51	R:R:I64	R:R:S144	4.64	No	No	0	5	7
52	R:R:I64	R:R:V148	6.14	No	No	0	5	7
53	R:R:F65	R:R:G120	3.01	Yes	No	0	7	6
54	R:R:F65	R:R:N124	7.25	Yes	Yes	5	7	8
55	R:R:F65	R:R:Y139	4.13	Yes	Yes	5	7	6
56	R:R:F65	R:R:S144	5.28	Yes	No	0	7	7
57	R:R:F65	R:R:Y147	3.09	Yes	Yes	5	7	5
58	R:R:F65	R:R:V148	3.93	Yes	No	0	7	7
59	R:R:N117	R:R:S68	8.94	No	No	0	7	9
60	R:R:S68	R:R:W152	6.18	No	Yes	0	9	9
61	R:R:D73	R:R:L69	4.07	Yes	No	0	9	9
62	R:R:L69	R:R:N117	5.49	No	No	0	9	7
63	R:R:L69	R:R:Y295	4.69	No	Yes	0	9	9
64	R:R:D73	R:R:S114	5.89	Yes	No	2	9	9
65	R:R:D73	R:R:S288	2.94	Yes	No	0	9	9
66	R:R:D73	R:R:N291	5.39	Yes	Yes	2	9	9
67	R:R:S110	R:R:V75	3.23	No	No	0	7	6
68	R:R:P80	R:R:V76	10.6	Yes	Yes	4	6	7
69	R:R:V76	R:R:Y81	6.31	Yes	Yes	0	7	7
70	R:R:M107	R:R:V76	3.04	No	Yes	4	6	7
71	R:R:S110	R:R:V76	9.7	No	Yes	0	7	7
72	R:R:P80	R:R:Y79	6.95	Yes	Yes	4	6	5
73	R:R:L83	R:R:Y79	11.72	No	Yes	4	6	5
74	R:R:H99	R:R:Y79	13.07	No	Yes	4	5	5
75	R:R:V102	R:R:Y79	6.31	No	Yes	0	4	5
76	R:R:L106	R:R:Y79	4.69	No	Yes	0	4	5
77	R:R:P80	R:R:S103	5.34	Yes	No	0	6	5
78	R:R:M107	R:R:P80	5.03	No	Yes	4	6	6
79	R:R:Y285	R:R:Y81	16.88	No	Yes	0	6	7
80	R:R:S288	R:R:Y81	6.36	No	Yes	0	9	7
81	R:R:H99	R:R:L83	7.71	No	No	4	5	6
82	R:R:L83	R:R:S103	3	No	No	0	6	5
83	R:R:S176	R:R:V84	6.46	No	No	0	4	6
84	R:R:F89	R:R:L85	7.31	No	No	0	4	6
85	R:R:S87	R:R:W93	3.71	No	Yes	0	5	8
86	R:R:I88	R:R:Y175	3.63	No	No	0	4	5
87	R:R:N90	R:R:N94	12.26	No	No	0	4	2
88	R:R:L95	R:R:W93	11.39	No	Yes	0	7	8
89	R:R:C100	R:R:W93	6.53	No	Yes	8	9	8
90	R:R:W93	R:R:Y170	9.65	Yes	Yes	8	8	1
91	R:R:C177	R:R:W93	5.22	No	Yes	8	9	8
92	R:R:H99	R:R:L95	16.71	No	No	0	5	7
93	R:R:Q101	R:R:Y97	18.04	No	No	0	6	2
94	R:R:C100	R:R:Q101	6.1	No	No	0	9	6
95	R:R:C100	R:R:C177	7.28	No	No	8	9	9
96	R:R:L168	R:R:Q101	5.32	No	No	0	5	6
97	R:R:G104	R:R:L168	5.13	No	No	0	5	5
98	R:R:F105	R:R:L109	4.87	Yes	No	9	6	5
99	R:R:F105	R:R:V159	10.49	Yes	No	9	6	7
100	R:R:F105	R:R:L160	3.65	Yes	No	0	6	4
101	R:R:M107	R:R:Y285	4.79	No	No	0	6	6
102	R:R:L109	R:R:L156	4.15	No	No	0	5	3
103	R:R:L109	R:R:V159	5.96	No	No	9	5	7
104	R:R:V111	R:R:W251	7.36	No	Yes	0	7	8
105	R:R:F116	R:R:I112	6.28	No	Yes	1	5	6
106	R:R:I112	R:R:T155	3.04	Yes	Yes	1	6	8
107	R:R:A158	R:R:I112	3.25	No	Yes	0	4	6
108	R:R:G113	R:R:T155	3.64	No	Yes	0	7	8
109	R:R:I115	R:R:S114	4.64	Yes	No	2	7	9
110	R:R:N291	R:R:S114	2.98	Yes	No	2	9	9
111	R:R:H195	R:R:I115	10.61	No	Yes	2	5	7
112	R:R:I115	R:R:P199	3.39	Yes	No	0	7	9
113	R:R:F247	R:R:I115	3.77	Yes	Yes	0	9	7
114	R:R:I115	R:R:W251	8.22	Yes	Yes	2	7	8
115	R:R:F116	R:R:T155	5.19	No	Yes	1	5	8
116	R:R:I151	R:R:N117	5.66	No	No	0	7	7
117	R:R:F247	R:R:I118	8.79	Yes	No	0	9	9
118	R:R:I118	R:R:N291	5.66	No	Yes	0	9	9
119	R:R:I118	R:R:Y295	9.67	No	Yes	0	9	9
120	R:R:P199	R:R:T119	3.5	No	No	0	9	7
121	R:R:I202	R:R:T119	4.56	No	No	0	6	7
122	R:R:I121	R:R:R125	6.26	No	Yes	6	9	9
123	R:R:I121	R:R:Y295	3.63	No	Yes	6	9	9
124	R:R:A122	R:R:V203	3.39	No	No	0	9	8
125	R:R:A122	R:R:C206	3.61	No	No	0	9	7
126	R:R:I123	R:R:Y139	3.63	No	Yes	0	6	6
127	R:R:I123	R:R:I202	2.94	No	No	0	6	6
128	R:R:N124	R:R:Y135	4.65	Yes	No	5	8	5
129	R:R:N124	R:R:Y139	5.81	Yes	Yes	5	8	6
130	R:R:R125	R:R:Y207	8.23	Yes	No	6	9	9
131	R:R:F244	R:R:R125	11.76	No	Yes	6	8	9
132	R:R:R125	R:R:Y295	6.17	Yes	Yes	6	9	9
133	R:R:C130	R:R:Y126	5.38	No	Yes	7	7	8
134	R:R:H131	R:R:Y126	13.07	No	Yes	7	6	8
135	R:R:F205	R:R:Y126	7.22	No	Yes	7	4	8
136	R:R:R209	R:R:Y126	11.32	No	Yes	7	4	8
137	R:R:C127	R:R:Y139	5.38	No	Yes	0	5	6
138	R:R:Y128	R:R:Y135	10.92	No	No	0	8	5
139	R:R:I129	R:R:I210	4.42	No	No	0	8	8
140	R:R:C130	R:R:H131	2.95	No	No	7	7	6
141	R:R:C130	R:R:L213	6.35	No	No	0	7	5
142	R:R:H131	R:R:K134	3.93	No	No	0	6	4
143	R:R:K134	R:R:L133	4.23	No	No	0	4	6
144	R:R:Y135	R:R:Y139	7.94	No	Yes	5	5	6
145	R:R:D136	R:R:K137	4.15	No	No	0	4	4
146	R:R:Y139	R:R:Y147	5.96	Yes	Yes	5	6	5
147	R:R:N143	R:R:S140	10.43	No	No	0	4	7
148	R:R:N143	R:R:Y147	3.49	No	Yes	0	4	5
149	R:R:T155	R:R:W152	6.06	Yes	Yes	0	8	9
150	R:R:P161	R:R:Y187	4.17	No	Yes	0	6	6
151	R:R:L163	R:R:N162	5.49	No	No	0	6	4
152	R:R:N162	R:R:Y187	6.98	No	Yes	0	4	6
153	R:R:F179	R:R:T167	3.89	Yes	Yes	0	4	4
154	R:R:T167	R:R:V183	4.76	Yes	No	0	4	1
155	R:R:S184	R:R:T167	4.8	No	Yes	0	4	4
156	R:R:A180	R:R:Q169	4.55	No	No	0	3	1
157	R:R:P172	R:R:Y170	4.17	No	Yes	0	3	1
158	R:R:Y170	R:R:Y175	4.96	Yes	No	0	1	5
159	R:R:C177	R:R:Y170	4.03	No	Yes	8	9	1
160	R:R:D171	R:R:P172	4.83	Yes	No	0	4	3
161	R:R:D171	R:R:R173	15.48	Yes	No	1	4	5
162	R:R:D171	R:R:I174	9.8	Yes	Yes	1	4	1
163	R:R:D171	R:R:F277	4.78	Yes	Yes	1	4	3
164	R:R:F277	R:R:R173	20.31	Yes	No	1	3	5
165	R:R:I174	R:R:T178	3.04	Yes	No	1	1	4
166	R:R:F277	R:R:I174	6.28	Yes	Yes	1	3	1
167	R:R:I174	R:R:V278	3.07	Yes	Yes	1	1	4
168	R:R:I174	R:R:Y281	13.3	Yes	Yes	1	1	5
169	R:R:I174	R:R:Y282	3.63	Yes	Yes	1	1	5
170	R:R:S176	R:R:Y285	5.09	No	No	0	4	6
171	R:R:T178	R:R:Y281	13.73	No	Yes	1	4	5
172	R:R:F179	R:R:Y187	7.22	Yes	Yes	0	4	6
173	R:R:F179	R:R:T188	6.49	Yes	No	0	4	5
174	R:R:F277	R:R:Q181	7.03	Yes	No	1	3	3
175	R:R:Q181	R:R:Y281	5.64	No	Yes	1	3	5
176	R:R:S184	R:R:Y187	5.09	No	Yes	0	4	6
177	R:R:V191	R:R:Y187	3.79	No	Yes	0	5	6
178	R:R:A262	R:R:T188	3.36	No	No	0	4	5
179	R:R:N255	R:R:V192	8.87	No	No	0	7	5
180	R:R:F194	R:R:V193	3.93	No	No	0	4	5
181	R:R:F194	R:R:V198	3.93	No	No	0	4	6
182	R:R:H195	R:R:W251	6.35	No	Yes	2	5	8
183	R:R:F196	R:R:M200	3.73	Yes	No	0	8	7
184	R:R:A252	R:R:F196	4.16	No	Yes	0	5	8
185	R:R:F196	R:R:N255	8.46	Yes	No	0	8	7
186	R:R:P199	R:R:V198	3.53	No	No	0	9	6
187	R:R:A248	R:R:M200	6.44	No	No	0	6	7
188	R:R:F247	R:R:V203	6.55	Yes	No	0	9	8
189	R:R:F241	R:R:I204	6.28	No	No	0	6	4
190	R:R:I204	R:R:V245	4.61	No	No	0	4	5
191	R:R:F205	R:R:R209	8.55	No	No	7	4	4
192	R:R:F244	R:R:Y207	22.69	No	No	6	8	9
193	R:R:D233	R:R:W211	6.7	No	Yes	0	7	5
194	R:R:F237	R:R:W211	20.04	No	Yes	0	6	5
195	R:R:I212	R:R:Q216	5.49	No	No	0	3	4
196	R:R:L213	R:R:V217	2.98	No	No	0	5	5
197	R:R:K222	R:R:R218	6.19	No	No	0	3	4
198	R:R:P223	R:R:Q219	6.32	No	No	0	3	4
199	R:R:K222	R:R:V221	3.04	No	No	0	3	5
200	R:R:K222	R:R:P223	3.35	No	No	0	3	3
201	R:R:Q232	R:R:R235	8.18	No	No	0	5	8
202	R:R:M240	R:R:N236	4.21	No	No	0	7	7
203	R:R:F237	R:R:F241	18.22	No	No	0	6	6
204	R:R:V238	R:R:V242	3.21	No	No	0	6	6
205	R:R:I294	R:R:V243	3.07	No	No	0	8	8
206	R:R:F244	R:R:Y295	12.38	No	Yes	6	8	9
207	R:R:A248	R:R:F247	6.93	No	Yes	0	6	9
208	R:R:F247	R:R:N287	3.62	Yes	Yes	0	9	9
209	R:R:C250	R:R:N287	9.45	No	Yes	0	8	9
210	R:R:A284	R:R:W251	5.19	No	Yes	0	7	8
211	R:R:N287	R:R:W251	11.3	Yes	Yes	0	9	8
212	R:R:P253	R:R:S280	7.13	No	No	0	9	7
213	R:R:L254	R:R:S280	6.01	Yes	No	0	6	7
214	R:R:L254	R:R:Y281	8.21	Yes	Yes	1	6	5
215	R:R:A284	R:R:L254	3.15	No	Yes	0	7	6
216	R:R:I257	R:R:I272	5.89	No	Yes	0	5	5
217	R:R:F277	R:R:I257	3.77	Yes	No	0	3	5
218	R:R:V261	R:R:V269	3.21	No	No	0	3	3
219	R:R:M268	R:R:S263	3.07	No	No	0	1	4
220	R:R:D264	R:R:P265	3.22	No	No	0	4	3
221	R:R:D264	R:R:S267	8.83	No	No	0	4	1
222	R:R:M268	R:R:S267	4.6	No	No	0	1	1
223	R:R:P270	R:R:V269	3.53	No	No	0	3	3
224	R:R:I272	R:R:P273	5.08	Yes	No	0	5	4
225	R:R:F277	R:R:Y281	6.19	Yes	Yes	1	3	5
226	R:R:V278	R:R:Y282	3.79	Yes	Yes	1	4	5
227	R:R:C289	R:R:F286	5.59	Yes	No	2	7	4
228	R:R:L290	R:R:N287	5.49	No	Yes	0	6	9
229	R:R:N287	R:R:N291	12.26	Yes	Yes	0	9	9
230	R:R:I294	R:R:Y295	7.25	No	Yes	0	8	9
231	R:R:L297	R:R:R303	3.64	No	No	0	6	9
232	R:R:N299	R:R:N301	13.62	No	No	0	8	6
233	R:R:F302	R:R:N299	12.08	Yes	No	0	8	8
234	R:R:Q300	R:R:R303	3.5	No	No	0	5	9
235	R:R:K304	R:R:Q300	12.2	No	No	0	5	5
236	R:R:F302	R:R:Y306	4.13	Yes	Yes	0	8	6
237	R:R:E305	R:R:Y306	3.37	No	Yes	0	6	6
238	R:R:E305	R:R:I309	8.2	No	Yes	3	6	6
239	R:R:R307	R:R:Y306	5.14	No	Yes	0	4	6
240	R:R:I310	R:R:R307	8.77	No	No	0	7	4
241	R:R:I272	R:R:L276	2.85	Yes	No	0	5	5
242	R:R:L26	R:R:L30	2.77	No	No	0	2	5
243	R:R:A31	R:R:F89	2.77	No	No	0	5	4
244	R:R:L34	R:R:L85	2.77	No	No	0	7	6
245	R:R:L43	R:R:L47	2.77	No	No	0	3	6
246	R:R:L46	R:R:L50	2.77	No	No	0	4	4
247	R:R:L150	R:R:L154	2.77	No	No	0	4	4
248	R:R:D233	R:R:K230	2.77	No	No	0	7	4
249	R:R:C206	R:R:Y126	2.69	No	Yes	0	7	8
250	R:R:C146	R:R:Y147	2.69	No	Yes	0	3	5
251	R:R:L215	R:R:Q219	2.66	No	No	0	5	4
252	R:R:F302	R:R:V52	2.62	Yes	No	0	8	7
253	R:R:F234	R:R:V238	2.62	No	No	0	4	6
254	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
255	R:R:I272	R:R:R271	2.51	Yes	No	0	5	4
256	R:R:F105	R:R:L163	2.44	Yes	No	0	6	6
257	R:R:F237	R:R:L208	2.44	No	No	0	6	3
258	R:R:I210	R:R:Y126	2.42	No	Yes	0	8	8
259	R:R:I129	R:R:Y128	2.42	No	No	0	8	8
260	R:R:N236	R:R:R235	2.41	No	No	0	7	8
261	R:R:I212	R:R:W211	2.35	No	Yes	0	3	5
262	R:R:L297	R:R:Y306	2.34	No	Yes	0	6	6
263	R:R:N91	R:R:Y175	2.33	No	No	0	4	5
264	R:R:M240	R:R:W211	2.33	No	Yes	0	7	5
265	R:R:L215	R:R:W211	2.28	No	Yes	0	5	5
266	R:R:F196	R:R:F256	2.14	Yes	No	0	8	6
267	R:R:G296	R:R:V48	1.84	No	No	0	6	8
268	R:R:G258	R:R:V261	1.84	No	No	0	4	3
269	R:R:G258	R:R:T188	1.82	No	No	0	4	5
270	R:R:P265	R:R:S185	1.78	No	No	0	3	3
271	R:R:C32	R:R:S28	1.72	No	No	0	5	4
272	R:R:A61	R:R:S141	1.71	No	No	0	6	3
273	R:R:A61	R:R:S144	1.71	No	No	0	6	7
274	R:R:G96	R:R:L95	1.71	No	No	0	7	7
275	R:R:A70	R:R:V48	1.7	No	No	0	9	8
276	R:R:G92	R:R:N94	1.7	No	No	0	4	2
277	R:R:A180	R:R:V183	1.7	No	No	0	3	1
278	R:R:A248	R:R:V245	1.7	No	No	0	6	5
279	R:R:A165	R:R:T167	1.68	No	Yes	0	5	4
280	R:R:M283	R:R:P253	1.68	No	No	0	7	9
281	R:R:K230	R:R:P231	1.67	No	No	0	4	3
282	R:R:A27	R:R:I88	1.62	No	No	0	2	4
283	R:R:A262	R:R:I189	1.62	No	No	0	4	5
284	R:R:T37	R:R:V33	1.59	No	No	0	6	4
285	R:R:C127	R:R:L138	1.59	No	No	0	5	4
286	R:R:I49	R:R:V67	1.54	No	No	0	7	6
287	R:R:I121	R:R:V66	1.54	No	No	0	9	8
288	R:R:I210	R:R:V214	1.54	No	No	0	8	8
289	R:R:A266	R:R:D264	1.54	No	No	0	2	4
290	R:R:K142	R:R:S140	1.53	No	No	0	3	7
291	R:R:M240	R:R:T239	1.51	No	No	0	7	8
292	R:R:L197	R:R:V192	1.49	No	No	0	4	5
293	R:R:L246	R:R:V242	1.49	No	No	0	6	6
294	R:R:G92	R:R:Y170	1.45	No	Yes	0	4	1
295	R:R:I249	R:R:L246	1.43	No	No	0	5	6
296	R:R:I294	R:R:L246	1.43	No	No	0	8	6
297	R:R:E274	R:R:V278	1.43	No	Yes	0	3	4
298	R:R:I293	R:R:L298	1.43	No	No	0	6	6
299	R:R:M86	R:R:N90	1.4	No	No	0	4	4
300	R:R:P82	R:R:Y81	1.39	No	Yes	0	8	7
301	R:R:P273	R:R:W275	1.35	No	No	0	4	3
302	R:R:R220	R:R:V217	1.31	No	No	0	4	5
303	R:R:A29	R:R:W25	1.3	No	No	0	3	3
304	R:R:M268	R:R:R271	1.24	No	No	0	1	4
305	R:R:V71	R:R:W152	1.23	No	Yes	0	6	9
306	R:R:F116	R:R:L154	1.22	No	No	0	5	4
307	R:R:I78	R:R:Y79	1.21	No	Yes	0	5	5
308	R:R:L98	R:R:Y97	1.17	No	No	0	2	2
309	R:R:R308	R:R:R54	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.85818	11	1	0
2	R:R:D41	6.3475	4	2	7
3	R:R:N45	6.448	5	2	9
4	R:R:F65	4.44833	6	5	7
5	R:R:D73	4.60833	6	2	9
6	R:R:V76	7.4125	4	4	7
7	R:R:Y79	7.325	6	4	5
8	R:R:P80	6.98	4	4	6
9	R:R:Y81	7.396	5	0	7
10	R:R:W93	7.3	5	8	8
11	R:R:F105	5.3625	4	9	6
12	R:R:I112	5.2375	4	1	6
13	R:R:I115	6.126	5	2	7
14	R:R:N124	5.7	4	5	8
15	R:R:R125	8.105	4	6	9
16	R:R:Y126	7.01667	6	7	8
17	R:R:Y139	5.475	6	5	6
18	R:R:Y147	3.8075	4	5	5
19	R:R:W152	4.015	4	0	9
20	R:R:T155	4.4825	4	1	8
21	R:R:T167	3.7825	4	0	4
22	R:R:Y170	4.852	5	8	1
23	R:R:D171	8.7225	4	1	4
24	R:R:I174	6.52	6	1	1
25	R:R:F179	10.5275	4	0	4
26	R:R:Y187	5.45	5	0	6
27	R:R:F196	4.6225	4	0	8
28	R:R:W211	6.74	5	0	5
29	R:R:F247	5.932	5	0	9
30	R:R:W251	7.684	5	2	8
31	R:R:L254	5.7925	4	1	6
32	R:R:I272	4.0825	4	0	5
33	R:R:F277	8.06	6	1	3
34	R:R:V278	3.19	4	1	4
35	R:R:Y281	8.33667	6	1	5
36	R:R:Y282	8.01	4	1	5
37	R:R:N287	8.424	5	0	9
38	R:R:C289	5.11	4	2	7
39	R:R:N291	6.5725	4	2	9
40	R:R:Y295	7.29833	6	6	9
41	R:R:F302	6.46667	6	3	8
42	R:R:Y306	4.3	6	0	6
43	R:R:I309	5.505	4	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T178	28.9002	3.71	Yes	No	1	0	4
2	R:R:I174	R:R:T178	28.2414	3.04	Yes	No	1	1	4
3	R:R:I174	R:R:V278	13.386	3.07	Yes	Yes	1	1	4
4	R:R:L26	R:R:L30	10.8525	2.77	No	No	0	2	5
5	L:L:?1	R:R:Y281	57.1654	2.95	Yes	Yes	1	0	5
6	R:R:I174	R:R:Y281	46.6319	13.3	Yes	Yes	1	1	5
7	R:R:I174	R:R:Y282	24.2146	3.63	Yes	Yes	1	1	5
8	R:R:L34	R:R:Y282	13.5887	5.86	No	Yes	0	7	5
9	R:R:L34	R:R:L85	10.8823	2.77	No	No	0	7	6
10	L:L:?1	R:R:V111	99.7496	11.24	Yes	No	0	0	7
11	R:R:V111	R:R:W251	100	7.36	No	Yes	0	7	8
12	R:R:I115	R:R:W251	76.9717	8.22	Yes	Yes	2	7	8
13	R:R:I115	R:R:S114	42.772	4.64	Yes	No	2	7	9
14	R:R:D73	R:R:S114	42.1252	5.89	Yes	No	2	9	9
15	R:R:D41	R:R:D73	17.7019	5.32	Yes	Yes	2	7	9
16	R:R:C289	R:R:D41	13.8033	4.67	Yes	Yes	2	7	7
17	R:R:N287	R:R:W251	62.5663	11.3	Yes	Yes	0	9	8
18	R:R:N287	R:R:N291	45.4128	12.26	Yes	Yes	0	9	9
19	R:R:D73	R:R:N291	45.2936	5.39	Yes	Yes	2	9	9
20	R:R:D73	R:R:S288	27.544	2.94	Yes	No	0	9	9
21	R:R:S288	R:R:Y81	26.0715	6.36	No	Yes	0	9	7
22	R:R:D73	R:R:N45	57.2608	4.04	Yes	Yes	2	9	9
23	R:R:A70	R:R:N45	53.8092	4.69	No	Yes	0	9	9
24	R:R:A70	R:R:V48	52.2534	1.7	No	No	0	9	8
25	R:R:V48	R:R:Y306	49.1028	3.79	No	Yes	0	8	6
26	R:R:F302	R:R:Y306	19.9493	4.13	Yes	Yes	0	8	6
27	R:R:E305	R:R:Y306	13.3621	3.37	No	Yes	0	6	6
28	R:R:I115	R:R:P199	36.0924	3.39	Yes	No	0	7	9
29	R:R:P199	R:R:T119	31.0373	3.5	No	No	0	9	7
30	R:R:I202	R:R:T119	29.7705	4.56	No	No	0	6	7
31	R:R:I123	R:R:I202	28.5574	2.94	No	No	0	6	6
32	R:R:I123	R:R:Y139	27.3353	3.63	No	Yes	0	6	6
33	R:R:F65	R:R:Y139	11.0015	4.13	Yes	Yes	5	7	6
34	L:L:?1	R:R:I112	12.0656	8.38	Yes	Yes	1	0	6
35	R:R:F247	R:R:I115	37.9464	3.77	Yes	Yes	0	9	7
36	R:R:F247	R:R:I118	31.4844	8.79	Yes	No	0	9	9
37	R:R:I118	R:R:Y295	29.2012	9.67	No	Yes	0	9	9
38	R:R:F247	R:R:N287	34.4292	3.62	Yes	Yes	0	9	9
39	R:R:I118	R:R:N291	18.6259	5.66	No	Yes	0	9	9
40	R:R:V76	R:R:Y81	16.4024	6.31	Yes	Yes	0	7	7
41	R:R:P80	R:R:V76	12.7958	10.6	Yes	Yes	4	6	7
42	R:R:D171	R:R:I174	39.4665	9.8	Yes	Yes	1	4	1
43	R:R:D171	R:R:P172	74.0835	4.83	Yes	No	0	4	3
44	R:R:P172	R:R:Y170	69.3443	4.17	No	Yes	0	3	1
45	R:R:W93	R:R:Y170	27.9613	9.65	Yes	Yes	8	8	1
46	R:R:L95	R:R:W93	12.155	11.39	No	Yes	0	7	8
47	R:R:H99	R:R:L95	11.3741	16.71	No	No	0	5	7
48	L:L:?1	R:R:Q181	28.8912	4.46	Yes	No	1	0	3
49	R:R:F277	R:R:Q181	28.2235	7.03	Yes	No	1	3	3
50	R:R:D171	R:R:F277	39.1207	4.78	Yes	Yes	1	4	3
51	R:R:F277	R:R:Y281	46.5127	6.19	Yes	Yes	1	3	5
52	R:R:Y170	R:R:Y175	13.6841	4.96	Yes	No	0	1	5
53	R:R:G92	R:R:Y170	13.6841	1.45	No	Yes	0	4	1
54	R:R:G92	R:R:N94	10.2712	1.7	No	No	0	4	2
55	R:R:C100	R:R:W93	15.2697	6.53	No	Yes	8	9	8
56	R:R:C177	R:R:Y170	16.0298	4.03	No	Yes	8	9	1
57	R:R:C100	R:R:C177	13.6602	7.28	No	No	8	9	9
58	R:R:C100	R:R:Q101	24.1252	6.1	No	No	0	9	6
59	L:L:?1	R:R:N162	14.7601	3.45	Yes	No	0	0	4
60	R:R:F247	R:R:V203	41.6751	6.55	Yes	No	0	9	8
61	R:R:A122	R:R:V203	39.07	3.39	No	No	0	9	8
62	R:R:A122	R:R:C206	36.5872	3.61	No	No	0	9	7
63	R:R:C206	R:R:Y126	34.1043	2.69	No	Yes	0	7	8
64	R:R:C130	R:R:Y126	10.6975	5.38	No	Yes	7	7	8
65	L:L:?1	R:R:F179	25.076	24.51	Yes	Yes	0	0	4
66	R:R:F179	R:R:T188	10.766	6.49	Yes	No	0	4	5
67	L:L:?1	R:R:N255	21.7288	4.6	Yes	No	0	0	7
68	R:R:F196	R:R:N255	18.5365	8.46	Yes	No	0	8	7
69	R:R:F196	R:R:M200	18.7869	3.73	Yes	No	0	8	7
70	R:R:A248	R:R:M200	18.9985	6.44	No	No	0	6	7
71	R:R:A248	R:R:V245	34.5007	1.7	No	No	0	6	5
72	R:R:I204	R:R:V245	32.9776	4.61	No	No	0	4	5
73	R:R:F241	R:R:I204	31.4486	6.28	No	No	0	6	4
74	R:R:F237	R:R:F241	29.9016	18.22	No	No	0	6	6
75	R:R:F237	R:R:W211	26.9329	20.04	No	Yes	0	6	5
76	R:R:I294	R:R:Y295	16.5991	7.25	No	Yes	0	8	9
77	R:R:I294	R:R:L246	11.9046	1.43	No	No	0	8	6
78	R:R:A284	R:R:L254	39.5142	3.15	No	Yes	0	7	6
79	R:R:F277	R:R:I257	35.1028	3.77	Yes	No	0	3	5
80	R:R:I257	R:R:I272	32.4382	5.89	No	Yes	0	5	5
81	R:R:I272	R:R:R271	21.7198	2.51	Yes	No	0	5	4
82	R:R:M268	R:R:R271	19.0253	1.24	No	No	0	1	4
83	R:R:M268	R:R:S267	13.6185	4.6	No	No	0	1	1
84	R:R:D264	R:R:S267	10.9061	8.83	No	No	0	4	1
85	R:R:P80	R:R:Y79	10.9151	6.95	Yes	Yes	4	6	5
86	R:R:A248	R:R:F247	23.9791	6.93	No	Yes	0	6	9
87	R:R:A284	R:R:W251	40.0089	5.19	No	Yes	0	7	8
88	R:R:L254	R:R:Y281	37.1803	8.21	Yes	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:G108	8.6	1	Yes	No	0	4	0	1
L:L:?1	R:R:V111	11.24	1	Yes	No	0	7	0	1
L:L:?1	R:R:I112	8.38	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N162	3.45	1	Yes	No	0	4	0	1
L:L:?1	R:R:T178	3.71	1	Yes	No	0	4	0	1
L:L:?1	R:R:F179	24.51	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q181	4.46	1	Yes	No	0	3	0	1
L:L:?1	R:R:V191	8.74	1	Yes	No	0	5	0	1
L:L:?1	R:R:L254	5.8	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N255	4.6	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y281	2.95	1	Yes	Yes	0	5	0	1
R:R:V111	R:R:W251	7.36	0	No	Yes	7	8	1	2
R:R:F116	R:R:I112	6.28	1	No	Yes	5	6	2	1
R:R:I112	R:R:T155	3.04	1	Yes	Yes	6	8	1	2
R:R:A158	R:R:I112	3.25	0	No	Yes	4	6	2	1
R:R:F116	R:R:T155	5.19	1	No	Yes	5	8	2	2
R:R:L163	R:R:N162	5.49	0	No	No	6	4	2	1
R:R:N162	R:R:Y187	6.98	0	No	Yes	4	6	1	2
R:R:F179	R:R:T167	3.89	0	Yes	Yes	4	4	1	2
R:R:I174	R:R:T178	3.04	1	Yes	No	1	4	2	1
R:R:F277	R:R:I174	6.28	1	Yes	Yes	3	1	2	2
R:R:I174	R:R:Y281	13.3	1	Yes	Yes	1	5	2	1
R:R:T178	R:R:Y281	13.73	1	No	Yes	4	5	1	1
R:R:F179	R:R:Y187	7.22	0	Yes	Yes	4	6	1	2
R:R:F179	R:R:T188	6.49	0	Yes	No	4	5	1	2
R:R:F277	R:R:Q181	7.03	1	Yes	No	3	3	2	1
R:R:Q181	R:R:Y281	5.64	1	No	Yes	3	5	1	1
R:R:V191	R:R:Y187	3.79	0	No	Yes	5	6	1	2
R:R:N255	R:R:V192	8.87	0	No	No	7	5	1	2
R:R:F196	R:R:N255	8.46	0	Yes	No	8	7	2	1
R:R:A284	R:R:W251	5.19	0	No	Yes	7	8	2	2
R:R:L254	R:R:S280	6.01	1	Yes	No	6	7	1	2
R:R:L254	R:R:Y281	8.21	1	Yes	Yes	6	5	1	1
R:R:A284	R:R:L254	3.15	0	No	Yes	7	6	2	1
R:R:F277	R:R:Y281	6.19	1	Yes	Yes	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VGZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	268
Number of Links	309
Number of Hubs	43
Number of Links mediated by Hubs	173
Number of Communities	9
Number of Nodes involved in Communities	60
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	90238
Length Of Smallest Path	3
Average Path Length	13.5352
Length of Longest Path	25
Minimum Path Strength	1.43
Average Path Strength	6.14551
Maximum Path Strength	17.535
Minimum Path Correlation	0.7
Average Path Correlation	0.928063
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	47.1023
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.8116
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• rhythmic process • circadian rhythm • behavior • multicellular organismal process • reproductive process • multicellular organismal reproductive process • reproductive behavior • mating behavior • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JEV
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JEV
Name	Ramelteon
Synonyms	Ramelteon
Identifier
Formula	C16 H21 N O2
Molecular Weight	259.343
SMILES
PubChem	208902
Formal Charge	0
Total Atoms	40
Total Chiral Atoms	1
Total Bonds	42
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P48039
Sequence	>7VGZ_nogp_Chain_R P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N K K L R N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G W N L G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S L K Y D K L Y S S K N S L C Y V L L I W L L T L A A V L P N L R A G T L Q Y D P R I Y S C T F A Q S V S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V K P K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P A S M V P R I P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N F R K E Y R R I I V S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VGY	A	Melatonin	Melatonin	MT₁	Homo sapiens	2-Iodomelatonin	-	Gi1/β1/γ2	3.1	2022-03-02	doi.org/10.1038/s41467-022-28111-3
	7VGY (No Gprot)	A	Melatonin	Melatonin	MT₁	Homo sapiens	2-Iodomelatonin	-		3.1	2022-03-02	doi.org/10.1038/s41467-022-28111-3
	7VGZ	A	Melatonin	Melatonin	MT₁	Homo sapiens	Remalteon	-	Gi1/β1/γ2	3.3	2022-03-02	doi.org/10.1038/s41467-022-28111-3
	7VGZ (No Gprot)	A	Melatonin	Melatonin	MT₁	Homo sapiens	Remalteon	-		3.3	2022-03-02	doi.org/10.1038/s41467-022-28111-3
	6ME2	A	Melatonin	Melatonin	MT₁	Homo sapiens	Ramelteon	-	-	2.8	2019-04-24	doi.org/10.1038/s41586-019-1141-3
	6ME3	A	Melatonin	Melatonin	MT₁	Homo sapiens	2-Phenylmelatonin	-	-	2.9	2019-04-24	doi.org/10.1038/s41586-019-1141-3
	6ME4	A	Melatonin	Melatonin	MT₁	Homo sapiens	2-Iodomelatonin	-	-	3.2	2019-04-24	doi.org/10.1038/s41586-019-1141-3
	6ME5	A	Melatonin	Melatonin	MT₁	Homo sapiens	Agomelatine	-	-	3.2	2019-04-24	doi.org/10.1038/s41586-019-1141-3
	7DB6	A	Melatonin	Melatonin	MT₁	Homo sapiens	Ramelteon	-	Gi1/β1/γ2	3.3	2021-08-18	doi.org/10.1038/s41594-021-00634-1
	7DB6 (No Gprot)	A	Melatonin	Melatonin	MT₁	Homo sapiens	Ramelteon	-		3.3	2021-08-18	doi.org/10.1038/s41594-021-00634-1
	6PS8	A	Melatonin	Melatonin	MT₁	Homo sapiens	2-Phenylmelatonin	-	-	3.3	2019-11-13	doi.org/10.1107/S2052252519013137

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