Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 2.815402
2A:A:V34 5.238575
3A:A:G45 3.62754109
4A:A:K46 3.078509
5A:A:F191 7.4525475
6A:A:L194 5.6525474
7A:A:F196 9.1825477
8A:A:M198 5.1475407
9A:A:F199 9.354515
10A:A:Q204 5.73419
11A:A:E207 7.424519
12A:A:K210 6.34875819
13A:A:W211 7.1225409
14A:A:F215 6.996519
15A:A:F223 6.21409
16A:A:Y230 5.24754208
17A:A:F250 6.3465169
18A:A:C254 4.275165
19A:A:W258 7.95167615
20A:A:I265 2.9275408
21A:A:N269 4.53254109
22A:A:F274 5.714209
23A:A:Y287 7.085717117
24A:A:E289 6.1754116
25A:A:Y296 5.064504
26A:A:Y302 11.93254116
27A:A:N311 6.09754168
28A:A:T324 6.03254109
29A:A:F336 6.426578
30A:A:F354 6.375185
31B:B:L14 3.36754238
32B:B:L51 9.4375449
33B:B:H54 10.442549
34B:B:Y59 10.15418
35B:B:W63 5.916257
36B:B:V71 4.00254158
37B:B:D76 4.05409
38B:B:I81 5.66754157
39B:B:W82 9.24571749
40B:B:N88 6.665407
41B:B:K89 6.77649
42B:B:H91 5.594155
43B:B:I93 5.3775407
44B:B:W99 9.73667619
45B:B:Y105 4.818577156
46B:B:N110 5.84254124
47B:B:Y111 6.3565124
48B:B:L117 4.24419
49B:B:N119 5.2675409
50B:B:C121 3.34418
51B:B:I123 3.734126
52B:B:Y124 5.8425406
53B:B:H142 7.082519
54B:B:Y145 5.855818
55B:B:C149 3.84418
56B:B:F151 4.67667609
57B:B:I157 4.3425417
58B:B:T159 4.9619
59B:B:D163 8.338519
60B:B:W169 7.99714718
61B:B:F180 7.19557
62B:B:H183 7.40571759
63B:B:D186 5.502519
64B:B:V187 4.6625459
65B:B:M188 5.445418
66B:B:F199 6459
67B:B:S201 4.915459
68B:B:C204 7.188517
69B:B:D205 6.656559
70B:B:K209 11.5725456
71B:B:W211 8.18833658
72B:B:R219 4.4775435
73B:B:Q220 6.578537
74B:B:F222 7.805438
75B:B:H225 8.38857739
76B:B:D228 7.064519
77B:B:I232 5.09438
78B:B:F235 6.135176
79B:B:P236 6.034177
80B:B:F241 7.086536
81B:B:T243 6.6575438
82B:B:D246 7.55419
83B:B:D247 8.2925439
84B:B:R251 11.705438
85B:B:F253 6.86286736
86B:B:D258 9.4925437
87B:B:Y264 6.27705
88B:B:F278 6.1454177
89B:B:R283 7.1599
90B:B:Y289 7.01714717
91B:B:D290 7.5575416
92B:B:W297 6.9625418
93B:B:D298 6.8325499
94B:B:L300 7.2875496
95B:B:R304 6.33415
96B:B:H311 7.76569
97B:B:R314 12.435418
98B:B:L318 3.33406
99B:B:M325 5.955405
100B:B:W332 11.3417619
101B:B:D333 6.04569
102B:B:F335 4.0225464
103B:B:K337 7.3625466
104B:B:W339 10.825469
105G:G:L19 3.19409
106G:G:R27 6.9375408
107G:G:Y40 9.1254176
108G:G:D48 6.275409
109G:G:N59 5.11549
110G:G:P60 6.475449
111G:G:F61 4.87429748
112R:R:P38 4.71405
113R:R:Y41 5.366676277
114R:R:N52 6.4775409
115R:R:V55 4.07754289
116R:R:L59 3.9175407
117R:R:M68 5.8825487
118R:R:I71 3.5775406
119R:R:Y72 10.3625487
120R:R:D80 8.012529
121R:R:F83 9.032526
122R:R:F89 8.128526
123R:R:W99 11.5667628
124R:R:F101 9.5975427
125R:R:Y113 7.208526
126R:R:T115 3.57405
127R:R:Y118 5.534317
128R:R:S119 6.84137
129R:R:E120 4.952529
130R:R:I121 4.2225428
131R:R:F123 9.0285137
132R:R:T128 4.7025429
133R:R:I135 5.14409
134R:R:V136 6.45754328
135R:R:R145 5.19714787
136R:R:I157 5.51407
137R:R:W158 7.7725139
138R:R:T174 7.122525
139R:R:H180 7.65401
140R:R:L185 3.3185144
141R:R:F187 10.62254145
142R:R:W195 9.195141
143R:R:P211 5.284529
144R:R:Y219 7.846529
145R:R:F248 7.904529
146R:R:F251 6.3225408
147R:R:W252 9.848529
148R:R:T253 7.0225406
149R:R:Y255 4.602526
150R:R:F264 5.2175404
151R:R:F269 5.0225401
152R:R:Y291 9.344526
153R:R:H293 12.685429
154R:R:C294 5.665429
155R:R:N297 7.29429
156R:R:Y301 6.181676309
157R:R:F303 4.425407
158R:R:E306 5.2165185
159R:R:F308 6.54254288
160R:R:Y311 8.054294
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I19 B:B:K89 12.86094.36NoYes099
2A:A:I19 A:A:R15 13.41623.76NoNo095
3A:A:R15 B:B:H91 13.6993.39NoYes055
4B:B:D66 B:B:R68 23.76543.57NoNo085
5B:B:D66 B:B:L69 24.04776.79NoNo085
6B:B:L69 B:B:Y105 24.42824.69NoYes056
7B:B:H62 B:B:Y105 45.93533.27NoYes066
8B:B:H62 B:B:R150 46.200415.8NoNo066
9B:B:C148 B:B:R150 47.99044.18NoNo066
10B:B:C148 B:B:T102 58.54023.38NoNo068
11B:B:C149 B:B:T102 59.28665.07YesNo088
12B:B:C149 B:B:T159 58.51073.38YesYes189
13B:B:H142 B:B:T159 64.89985.48YesYes199
14B:B:H142 B:B:S161 46.693215.34YesNo199
15B:B:G162 B:B:S161 47.20473.71NoNo199
16B:B:G162 B:B:Y145 47.026610.14NoYes198
17B:B:L117 B:B:Y145 22.81023.52YesYes198
18A:A:Q204 B:B:Y145 36.58785.64YesYes198
19A:A:Q204 A:A:W211 63.58237.67YesYes099
20A:A:R208 A:A:W211 1007NoYes099
21A:A:L249 A:A:R208 99.59134.86NoNo099
22A:A:F223 A:A:L249 99.52356.09YesNo099
23A:A:F223 A:A:G40 90.04563.01YesNo099
24A:A:G40 A:A:K46 89.94673.49NoYes099
25A:A:C224 A:A:K46 89.34783.23NoYes079
26A:A:C224 A:A:I49 12.99544.91NoNo077
27B:B:D163 B:B:H142 26.72487.56YesYes199
28B:B:D163 B:B:G144 27.01895.03YesNo098
29B:B:G144 B:B:N119 27.14995.09NoYes089
30A:A:Q204 B:B:N119 27.54365.28YesYes099
31A:A:F215 A:A:W211 36.86624.01YesYes099
32A:A:F215 B:B:W99 35.409812.03YesYes199
33A:A:C224 A:A:G45 83.69433.92NoYes079
34A:A:G45 A:A:N269 84.44875.09YesYes1099
35A:A:N269 A:A:T324 84.15945.85YesYes1099
36A:A:K210 B:B:Y145 18.13843.58YesYes198
37A:A:K210 B:B:D246 17.10675.53YesYes199
38A:A:C214 B:B:L117 21.88463.17NoYes179
39A:A:C214 B:B:Y59 21.52225.38NoYes178
40A:A:H213 B:B:Y59 37.92125.44NoYes188
41A:A:H213 A:A:W258 18.89788.46NoYes185
42A:A:H213 B:B:W332 18.8986.35NoYes189
43B:B:K57 B:B:Y59 19.0428.36NoYes098
44B:B:K57 B:B:W332 18.898724.37NoYes099
45B:B:Q75 B:B:W99 35.75347.67NoYes199
46A:A:F223 A:A:F250 20.726410.72YesYes099
47A:A:L266 A:A:L268 11.74276.92NoNo098
48A:A:F250 A:A:L266 12.74863.65YesNo099
49A:A:W258 B:B:R314 18.31835YesYes158
50B:B:R314 B:B:W332 36.56522.99YesYes189
51A:A:F267 A:A:T324 83.86665.19NoYes099
52A:A:F267 A:A:I265 83.49973.77NoYes098
53A:A:A338 A:A:I265 83.12983.25NoYes068
54A:A:A338 A:A:Y320 83.00594NoNo067
55A:A:D341 A:A:Y320 82.63224.6NoNo087
56A:A:D341 R:R:R229 82.50713.1NoNo085
57R:R:R228 R:R:R229 82.25556.4NoNo045
58R:R:I225 R:R:R228 82.12936.26NoNo054
59R:R:I135 R:R:I225 81.49354.42YesNo095
60A:A:L348 R:R:I135 37.07985.71NoYes099
61A:A:F354 A:A:L348 35.74759.74YesNo059
62A:A:F354 A:A:K349 33.57263.72YesNo1855
63A:A:K349 R:R:R307 33.66074.95NoNo056
64R:R:R307 R:R:Y311 33.54236.17NoYes064
65R:R:V58 R:R:Y311 32.96723.79NoYes074
66R:R:L312 R:R:V58 32.85458.94NoNo057
67R:R:F308 R:R:L312 32.07774.87YesNo085
68R:R:F308 R:R:V55 30.49286.55YesYes2889
69R:R:L59 R:R:V55 34.76982.98YesYes079
70R:R:L59 R:R:S70 33.47683YesNo078
71R:R:N67 R:R:S70 33.04327.45NoNo078
72A:A:D350 R:R:N67 11.50115.39NoNo047
73A:A:D350 R:R:R145 11.26933.57NoYes047
74R:R:N67 R:R:T69 21.3254.39NoNo078
75R:R:R145 R:R:T69 11.26913.88YesNo878
76R:R:C218 R:R:T128 44.13083.38NoYes089
77R:R:C218 R:R:Y132 44.19488.06NoNo088
78R:R:V136 R:R:Y132 44.125812.62YesNo3288
79R:R:I135 R:R:V136 45.10183.07YesYes098
80B:B:D246 B:B:S227 17.00755.89YesNo096
81B:B:S227 B:B:S245 16.81323.26NoNo069
82B:B:H225 B:B:S245 15.57999.76YesNo399
83B:B:F253 B:B:H225 12.33034.53YesYes369
84B:B:F222 B:B:F253 10.134211.79YesYes386
85B:B:D290 B:B:R314 35.785517.87YesYes168
86B:B:C271 B:B:D290 35.26454.67NoYes156
87B:B:C271 B:B:Y289 32.29494.03NoYes157
88B:B:W297 B:B:Y289 26.40187.72YesYes187
89B:B:W297 B:B:Y264 25.463810.61YesYes085
90B:B:R68 B:B:Y85 20.070325.72NoNo054
91B:B:Y85 G:G:P60 12.92878.34NoYes449
92B:B:M325 G:G:P60 10.17646.71YesYes059
93B:B:R314 B:B:T274 18.62573.88YesNo188
94B:B:S275 B:B:T274 18.57853.2NoNo088
95B:B:L318 B:B:S275 18.08213YesNo068
96B:B:C294 B:B:L318 16.09343.17NoYes056
97B:B:C294 B:B:L308 15.59544.76NoNo057
98B:B:L308 B:B:W339 13.100719.36NoYes079
99B:B:H91 B:B:I81 13.76359.28YesYes1557
100B:B:F151 B:B:I157 12.35327.54YesYes097
101B:B:C148 B:B:L190 12.33676.35NoNo065
102B:B:L285 B:B:Y264 15.59278.21NoYes065
103B:B:F278 B:B:L285 14.09738.53YesNo076
104R:R:M215 R:R:T128 38.88246.02NoYes289
105R:R:F248 R:R:M215 39.43157.46YesNo298
106R:R:F248 R:R:W252 30.564813.03YesYes299
107R:R:W252 R:R:Y255 28.64784.82YesYes296
108R:R:Y113 R:R:Y255 27.36355.96YesYes266
109R:R:Y113 R:R:Y291 15.74774.96YesYes266
110R:R:D80 R:R:N52 10.463710.77YesYes099
111R:R:M68 R:R:R145 19.22663.72YesYes877
112R:R:G150 R:R:M68 12.97353.49NoYes877
113R:R:G150 R:R:I71 12.25843.53NoYes076
114R:R:M68 R:R:Y72 15.135810.78YesYes877
115R:R:L126 R:R:Y72 13.700317.58NoYes877
116R:R:I157 R:R:L126 12.98494.28YesNo077
117R:R:W90 R:R:Y291 10.02843.86NoYes266
118R:R:Y113 R:R:Y114 14.1578.94YesNo064
119R:R:L185 R:R:Y114 12.39013.52YesNo044
120R:R:F187 R:R:L185 11.13393.65YesYes1454
121B:B:I81 B:B:Y105 14.287.25YesYes1576
122B:B:Q75 B:B:Y59 35.546721.42NoYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7VL8
Class A
SubFamily Protein
Type Chemokine
SubType CCR1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-03-23
D.O.I. 10.1038/s41589-021-00918-z
Net Summary
Imin 3.01
Number of Linked Nodes 868
Number of Links 1039
Number of Hubs 160
Number of Links mediated by Hubs 595
Number of Communities 34
Number of Nodes involved in Communities 253
Number of Links involved in Communities 357
Path Summary
Number Of Nodes in MetaPath 123
Number Of Links MetaPath 122
Number of Shortest Paths 1015792
Length Of Smallest Path 3
Average Path Length 34.2597
Length of Longest Path 69
Minimum Path Strength 1.305
Average Path Strength 6.46842
Maximum Path Strength 23.68
Minimum Path Correlation 0.7
Average Path Correlation 0.979795
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 42.9268
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2356
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VL8_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ASMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VL8_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VL8_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32246
Sequence
>7VL8_Chain_R
QLLPPLYSL VFVIGLVGN ILVVLVLVQ YKRLKNMTS IYLLNLAIS 
DLLFLFTLP FWIDYKLKD DWVFGDAMC KILSGFYYT GLYSEIFFI 
ILLTIDRYL AIVHAVFAL RARTVTFGV ITSIIIWAL AILASMPGL 
YFSKTQWEF THHTCSLHF PHESLREWK LFQALKLNL FGLVLPLLV 
MIICYTGII KILLRRPNE KKSKAVRLI FVIMIIFFL FWTPYNLTI 
LISVFQDFL FTHECEQSR HLDLAVQVT EVIAYTHCC VNPVIYAFV 
GERFRKYLR QLFHR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VL8AProteinChemokineCCR1Homo sapiens--Gi1/&β;1/&γ;22.92022-03-2310.1038/s41589-021-00918-z
7VL9AProteinChemokineCCR1Homo sapiensCCL15(26-92)-Gi1/&β;1/&γ;22.62022-03-2310.1038/s41589-021-00918-z
7VLAAProteinChemokineCCR1Homo sapiensCCL15(27-92)-Gi1/&β;1/&γ;22.72022-03-2310.1038/s41589-021-00918-z




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VL8.zip



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