Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 2.815402
2A:A:V34 5.238575
3A:A:G45 3.62754109
4A:A:K46 3.078509
5A:A:F191 7.4525475
6A:A:L194 5.6525474
7A:A:F196 9.1825477
8A:A:F199 8.188515
9A:A:Q204 5.73419
10A:A:E207 5.5675419
11A:A:R208 6.3875409
12A:A:K210 5.81857719
13A:A:W211 7.1225409
14A:A:F215 6.996519
15A:A:F223 6.21409
16A:A:Y230 5.24754208
17A:A:F250 6.3465159
18A:A:C254 4.275155
19A:A:W258 7.95167615
20A:A:I265 2.9275408
21A:A:N269 4.53254109
22A:A:F274 5.714209
23A:A:Y287 6.161437167
24A:A:Y290 7.265407
25A:A:Y296 4.085404
26A:A:Y302 10.534166
27A:A:N311 6.09754158
28A:A:T324 6.03254109
29A:A:F336 6.426578
30A:A:F354 6.375185
31B:B:L14 3.36754238
32B:B:L51 9.4375449
33B:B:H54 10.442549
34B:B:Y59 10.15418
35B:B:W63 5.916257
36B:B:V71 4.00254148
37B:B:D76 4.05409
38B:B:I81 5.66754147
39B:B:W82 9.24571749
40B:B:N88 6.665407
41B:B:K89 6.77649
42B:B:H91 5.594145
43B:B:I93 5.3775407
44B:B:W99 9.94519
45B:B:Y105 4.818577146
46B:B:N110 5.84254114
47B:B:Y111 6.3565114
48B:B:L117 4.24419
49B:B:N119 5.2675409
50B:B:C121 3.34418
51B:B:I123 3.734116
52B:B:Y124 5.8425406
53B:B:E130 7.5025403
54B:B:H142 7.082519
55B:B:Y145 5.855818
56B:B:C149 3.84418
57B:B:F151 4.67667609
58B:B:I157 4.3425417
59B:B:T159 4.9619
60B:B:D163 8.338519
61B:B:W169 7.99714718
62B:B:F180 7.19557
63B:B:H183 7.40571759
64B:B:D186 5.502519
65B:B:V187 4.6625459
66B:B:M188 5.445418
67B:B:F199 6459
68B:B:S201 4.915459
69B:B:C204 7.188517
70B:B:D205 6.656559
71B:B:K209 11.5725456
72B:B:W211 8.18833658
73B:B:R219 4.4775435
74B:B:Q220 6.578537
75B:B:F222 7.805438
76B:B:H225 8.38857739
77B:B:D228 7.1025419
78B:B:I232 5.09438
79B:B:F235 6.135176
80B:B:P236 6.034177
81B:B:F241 7.086536
82B:B:T243 6.6575438
83B:B:D246 7.55419
84B:B:D247 8.2925439
85B:B:R251 11.705438
86B:B:F253 6.86286736
87B:B:D258 9.4925437
88B:B:Y264 6.27705
89B:B:F278 6.1454177
90B:B:R283 7.1599
91B:B:Y289 7.01714717
92B:B:D290 7.5575416
93B:B:W297 6.9625418
94B:B:D298 6.8325499
95B:B:L300 7.2875496
96B:B:R304 6.33415
97B:B:H311 7.76569
98B:B:R314 12.435418
99B:B:L318 3.33406
100B:B:M325 5.955405
101B:B:W332 11.3417619
102B:B:D333 6.04569
103B:B:F335 4.0225464
104B:B:K337 7.3625466
105B:B:W339 10.825469
106G:G:L19 3.19409
107G:G:R27 6.9375408
108G:G:Y40 9.1254176
109G:G:D48 6.275409
110G:G:N59 5.11549
111G:G:P60 6.475449
112G:G:F61 4.87429748
113R:R:P38 4.71405
114R:R:Y41 5.366676277
115R:R:N52 6.4775409
116R:R:V55 4.07754289
117R:R:L59 3.9175407
118R:R:M68 5.8825487
119R:R:I71 3.5775406
120R:R:Y72 10.3625487
121R:R:D80 8.012529
122R:R:F83 9.032526
123R:R:F89 8.128526
124R:R:W99 11.5667628
125R:R:F101 9.5975427
126R:R:Y113 7.208526
127R:R:T115 3.57405
128R:R:Y118 5.534317
129R:R:S119 6.84127
130R:R:E120 4.952529
131R:R:I121 4.2225428
132R:R:F123 9.0285127
133R:R:T128 4.7025429
134R:R:I135 5.14409
135R:R:V136 6.45754328
136R:R:R145 5.19714787
137R:R:I157 5.51407
138R:R:W158 7.7725129
139R:R:T174 7.122525
140R:R:H180 7.65401
141R:R:L185 3.3185134
142R:R:F187 10.62254135
143R:R:W195 9.195131
144R:R:P211 5.284529
145R:R:Y219 7.846529
146R:R:F248 7.904529
147R:R:F251 6.3225408
148R:R:W252 9.848529
149R:R:T253 7.0225406
150R:R:Y255 4.602526
151R:R:F264 5.2175404
152R:R:F269 5.0225401
153R:R:Y291 9.344526
154R:R:H293 12.685429
155R:R:C294 5.665429
156R:R:N297 7.29429
157R:R:Y301 6.181676309
158R:R:F303 4.425407
159R:R:E306 5.2165185
160R:R:F308 6.54254288
161R:R:Y311 8.054294
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I19 B:B:K89 11.87324.36NoYes099
2A:A:I19 A:A:R15 12.26953.76NoNo095
3A:A:R15 B:B:H91 12.47353.39NoYes055
4B:B:H91 B:B:V133 11.72784.15YesNo054
5B:B:I93 B:B:V133 12.77446.14YesNo074
6B:B:I93 B:B:Y124 13.03384.84YesYes076
7B:B:S122 B:B:Y124 14.03916.36NoYes086
8B:B:E138 B:B:S122 14.18132.87NoNo068
9B:B:E138 B:B:I120 14.32684.1NoNo066
10B:B:D118 B:B:I120 14.64398.4NoNo096
11B:B:D118 B:B:S97 14.802710.31NoNo098
12A:A:E186 B:B:S97 14.96882.87NoNo098
13A:A:E186 A:A:F199 15.14334.66NoYes095
14A:A:F215 A:A:W211 48.84454.01YesYes099
15A:A:R208 A:A:W211 1007YesYes099
16A:A:L249 A:A:R208 99.59344.86NoYes099
17A:A:F223 A:A:L249 99.41566.09YesNo099
18A:A:F223 A:A:G40 90.24663.01YesNo099
19A:A:G40 A:A:K46 90.15513.49NoYes099
20A:A:C224 A:A:K46 89.69283.23NoYes079
21A:A:C224 A:A:I49 14.03644.91NoNo077
22A:A:F189 A:A:M198 12.73386.22NoNo097
23A:A:F223 A:A:F250 19.558810.72YesYes099
24A:A:F250 A:A:L266 10.16653.65YesNo099
25A:A:C224 A:A:G45 84.15713.92NoYes079
26A:A:G45 A:A:N269 85.72435.09YesYes1099
27A:A:N269 A:A:T324 85.57265.85YesYes1099
28B:B:D66 B:B:R68 20.26653.57NoNo085
29B:B:D66 B:B:L69 20.58076.79NoNo085
30B:B:L69 B:B:Y105 20.61894.69NoYes056
31B:B:H62 B:B:Y105 24.64213.27NoYes066
32B:B:H62 B:B:R150 24.935515.8NoNo066
33B:B:C148 B:B:R150 26.92394.18NoNo066
34B:B:C148 B:B:T102 38.64833.38NoNo068
35B:B:C149 B:B:T102 39.4795.07YesNo088
36B:B:C149 B:B:T159 38.64543.38YesYes189
37B:B:H142 B:B:T159 46.04375.48YesYes199
38B:B:D163 B:B:H142 20.05267.56YesYes199
39B:B:D163 B:B:G144 20.38925.03YesNo098
40B:B:G144 B:B:N119 20.53785.09NoYes089
41B:B:H142 B:B:S161 35.735915.34YesNo199
42B:B:G162 B:B:S161 36.30473.71NoNo199
43B:B:G162 B:B:Y145 36.182210.14NoYes198
44B:B:L117 B:B:Y145 19.3743.52YesYes198
45A:A:Q204 B:B:Y145 30.91355.64YesYes198
46A:A:Q204 B:B:N119 20.98915.28YesYes099
47A:A:K210 B:B:Y145 19.75613.58YesYes198
48A:A:K210 B:B:D246 18.82555.53YesYes199
49B:B:Q75 B:B:W99 44.46367.67NoYes199
50B:B:Q75 B:B:Y59 44.200121.42NoYes198
51A:A:H213 B:B:Y59 41.59875.44NoYes188
52A:A:H213 A:A:W258 20.7318.46NoYes185
53A:A:H213 B:B:W332 20.73086.35NoYes189
54B:B:K57 B:B:Y59 20.88848.36NoYes098
55B:B:K57 B:B:W332 20.731524.37NoYes099
56A:A:C214 B:B:L117 18.7893.17NoYes179
57A:A:W258 B:B:R314 20.09645YesYes158
58B:B:R314 B:B:W332 40.112322.99YesYes189
59A:A:F267 A:A:T324 85.30225.19NoYes099
60A:A:F267 A:A:I265 84.94933.77NoYes098
61A:A:A338 A:A:I265 84.59313.25NoYes068
62A:A:A338 A:A:Y320 84.47364NoNo067
63A:A:D341 A:A:Y320 84.11314.6NoNo087
64A:A:D341 R:R:R229 83.992213.1NoNo085
65R:R:R228 R:R:R229 83.74946.4NoNo045
66R:R:I225 R:R:R228 83.62746.26NoNo054
67R:R:I135 R:R:I225 83.01214.42YesNo095
68A:A:L348 R:R:I135 37.82155.71NoYes099
69A:A:F354 A:A:L348 36.50499.74YesNo059
70A:A:F354 A:A:K349 34.253.72YesNo1855
71A:A:K349 R:R:R307 34.36674.95NoNo056
72R:R:R307 R:R:Y311 34.25346.17NoYes064
73R:R:V58 R:R:Y311 33.70573.79NoYes074
74R:R:L312 R:R:V58 33.59888.94NoNo057
75R:R:F308 R:R:L312 32.86364.87YesNo085
76R:R:F308 R:R:V55 31.216.55YesYes2889
77R:R:L59 R:R:V55 36.012.98YesYes079
78R:R:L59 R:R:S70 34.68143YesNo078
79R:R:N67 R:R:S70 34.23577.45NoNo078
80A:A:D350 R:R:N67 11.91685.39NoNo047
81A:A:D350 R:R:R145 11.67723.57NoYes047
82R:R:N67 R:R:T69 22.09574.39NoNo078
83R:R:R145 R:R:T69 11.6773.88YesNo878
84R:R:C218 R:R:T128 45.04253.38NoYes089
85R:R:C218 R:R:Y132 45.09538.06NoNo088
86R:R:V136 R:R:Y132 44.999812.62YesNo3288
87R:R:I135 R:R:V136 45.9943.07YesYes098
88B:B:D246 B:B:S227 18.7035.89YesNo096
89B:B:S227 B:B:S245 18.48953.26NoNo069
90B:B:H225 B:B:S245 17.13349.76YesNo399
91B:B:F253 B:B:H225 13.56084.53YesYes369
92B:B:F222 B:B:F253 11.146911.79YesYes386
93B:B:D290 B:B:R314 39.258517.87YesYes168
94B:B:C271 B:B:D290 38.69464.67NoYes156
95B:B:C271 B:B:Y289 35.43634.03NoYes157
96B:B:W297 B:B:Y289 28.97117.72YesYes187
97B:B:W297 B:B:Y264 27.942810.61YesYes085
98B:B:R68 B:B:Y85 19.021625.72NoNo054
99B:B:Y85 G:G:P60 14.00878.34NoYes449
100B:B:M325 G:G:P60 11.26626.71YesYes059
101B:B:R314 B:B:T274 20.43263.88YesNo188
102B:B:S275 B:B:T274 20.38813.2NoNo088
103B:B:L318 B:B:S275 19.84353YesNo068
104B:B:C294 B:B:L318 17.66133.17NoYes056
105B:B:C294 B:B:L308 17.11494.76NoNo057
106B:B:L308 B:B:W339 14.377319.36NoYes079
107B:B:F151 B:B:I157 14.29267.54YesYes097
108B:B:F151 B:B:I123 10.41193.77YesYes096
109B:B:C148 B:B:L190 13.60246.35NoNo065
110B:B:L285 B:B:Y264 17.11258.21NoYes065
111B:B:F278 B:B:L285 15.47168.53YesNo076
112R:R:M215 R:R:T128 39.6996.02NoYes289
113R:R:F248 R:R:M215 40.32917.46YesNo298
114R:R:F248 R:R:W252 31.271713.03YesYes299
115R:R:W252 R:R:Y255 29.37814.82YesYes296
116R:R:Y113 R:R:Y255 28.05935.96YesYes266
117R:R:Y113 R:R:Y291 16.20044.96YesYes266
118R:R:D80 R:R:N52 11.281210.77YesYes099
119R:R:M68 R:R:R145 19.9263.72YesYes877
120R:R:G150 R:R:M68 13.44513.49NoYes877
121R:R:G150 R:R:I71 12.70453.53NoYes076
122R:R:D130 R:R:T69 10.18618.67NoNo888
123R:R:M68 R:R:Y72 15.68610.78YesYes877
124R:R:L126 R:R:Y72 14.198717.58NoYes877
125R:R:I157 R:R:L126 13.45774.28YesNo077
126R:R:W90 R:R:Y291 10.44383.86NoYes266
127R:R:W90 R:R:W99 10.18854.69NoYes268
128R:R:Y113 R:R:Y114 14.74458.94YesNo064
129R:R:L185 R:R:Y114 12.90683.52YesNo044
130R:R:F187 R:R:L185 11.60063.65YesYes1354
131A:A:Q204 A:A:W211 51.31227.67YesYes099
132A:A:F215 B:B:W99 39.107412.03YesYes199
133A:A:C214 B:B:Y59 18.4025.38NoYes178
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7VL8
Class A
SubFamily Protein
Type Chemokine
SubType CCR1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-03-23
D.O.I. doi.org/10.1038/s41589-021-00918-z
Net Summary
Imin 3.01
Number of Linked Nodes 866
Number of Links 1032
Number of Hubs 161
Number of Links mediated by Hubs 594
Number of Communities 34
Number of Nodes involved in Communities 250
Number of Links involved in Communities 349
Path Summary
Number Of Nodes in MetaPath 134
Number Of Links MetaPath 133
Number of Shortest Paths 941685
Length Of Smallest Path 3
Average Path Length 33.4271
Length of Longest Path 69
Minimum Path Strength 1.335
Average Path Strength 6.50111
Maximum Path Strength 23.68
Minimum Path Correlation 0.7
Average Path Correlation 0.979027
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 43.7136
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.5062
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • C-C chemokine binding   • chemokine binding   • chemokine (C-C motif) ligand 7 binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • molecular transducer activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • chemokine (C-C motif) ligand 5 binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell surface receptor signaling pathway   • response to cytokine   • cytokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • immune response   • immune system process   • response to chemokine   • cellular response to chemokine   • chemokine-mediated signaling pathway   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • calcium-mediated signaling   • chemotaxis   • taxis   • response to external stimulus   • locomotion   • cell chemotaxis   • dendritic cell chemotaxis   • leukocyte migration   • dendritic cell migration   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • monocyte chemotaxis   • myeloid leukocyte migration   • positive regulation of monocyte chemotaxis   • positive regulation of locomotion   • regulation of cell motility   • regulation of response to external stimulus   • positive regulation of chemotaxis   • positive regulation of cell migration   • regulation of monocyte chemotaxis   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • positive regulation of mononuclear cell migration   • regulation of immune system process   • regulation of mononuclear cell migration   • positive regulation of immune system process   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • regulation of chemotaxis   • regulation of locomotion   • response to stress   • response to wounding   • regulation of localization   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • calcium ion transport   • metal ion transport   • localization   • positive regulation of transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • monoatomic cation transport   • regulation of metal ion transport   • cell adhesion   • defense response   • inflammatory response   • regulation of biosynthetic process   • negative regulation of metabolic process   • negative regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • negative regulation of gene expression   • biosynthetic process   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of cellular process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • negative regulation of macromolecule metabolic process   • secretion by cell   • exocytosis   • secretion   • export from cell   • vesicle-mediated transport   • regulation of developmental process   • negative regulation of biomineral tissue development   • regulation of biomineral tissue development   • regulation of bone mineralization   • negative regulation of bone mineralization   • ossification   • biomineral tissue development   • regulation of multicellular organismal process   • regulation of multicellular organismal development   • negative regulation of developmental process   • bone mineralization   • tissue development   • negative regulation of ossification   • negative regulation of multicellular organismal process   • regulation of ossification   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • cellular developmental process   • cell development   • regulation of cell differentiation   • positive regulation of osteoclast differentiation   • regulation of cell development   • positive regulation of developmental process   • regulation of osteoclast differentiation   • positive regulation of cell differentiation   • positive regulation of hemopoiesis   • cell differentiation   • osteoclast differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • positive regulation of cell development   • regulation of myeloid leukocyte differentiation   • positive regulation of myeloid leukocyte differentiation   • myeloid cell differentiation   • positive regulation of myeloid cell differentiation   • regulation of hemopoiesis   • positive regulation of multicellular organismal process   • positive regulation of leukocyte differentiation   • leukocyte differentiation   • cell surface   • external side of plasma membrane
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VL8_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ASMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VL8_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VL8_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32246
Sequence
>7VL8_Chain_R
QLLPPLYSL VFVIGLVGN ILVVLVLVQ YKRLKNMTS IYLLNLAIS 
DLLFLFTLP FWIDYKLKD DWVFGDAMC KILSGFYYT GLYSEIFFI 
ILLTIDRYL AIVHAVFAL RARTVTFGV ITSIIIWAL AILASMPGL 
YFSKTQWEF THHTCSLHF PHESLREWK LFQALKLNL FGLVLPLLV 
MIICYTGII KILLRRPNE KKSKAVRLI FVIMIIFFL FWTPYNLTI 
LISVFQDFL FTHECEQSR HLDLAVQVT EVIAYTHCC VNPVIYAFV 
GERFRKYLR QLFHR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VL8AProteinChemokineCCR1Homo sapiens--Gi1/β1/γ22.92022-03-23doi.org/10.1038/s41589-021-00918-z
7VL8 (No Gprot) AProteinChemokineCCR1Homo sapiens--2.92022-03-23doi.org/10.1038/s41589-021-00918-z
7VL9AProteinChemokineCCR1Homo sapiensCCL15(26-92)-Gi1/β1/γ22.62022-03-23doi.org/10.1038/s41589-021-00918-z
7VL9 (No Gprot) AProteinChemokineCCR1Homo sapiensCCL15(26-92)-2.62022-03-23doi.org/10.1038/s41589-021-00918-z
7VLAAProteinChemokineCCR1Homo sapiensCCL15(27-92)-Gi1/β1/γ22.72022-03-23doi.org/10.1038/s41589-021-00918-z
7VLA (No Gprot) AProteinChemokineCCR1Homo sapiensCCL15(27-92)-2.72022-03-23doi.org/10.1038/s41589-021-00918-z




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