psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F47	R:R:Y41	8.25	Yes	Yes	2	4	7
2	L:L:F47	R:R:L87	3.65	Yes	No	0	4	7
3	L:L:F47	R:R:W90	31.07	Yes	Yes	2	4	6
4	L:L:F47	R:R:K94	7.44	Yes	Yes	2	4	4
5	L:L:F47	R:R:Y113	9.28	Yes	Yes	2	4	6
6	L:L:F47	R:R:Y291	7.22	Yes	Yes	2	4	6
7	L:L:E76	L:L:H48	6.15	No	Yes	0	4	6
8	L:L:H48	R:R:D280	5.04	Yes	Yes	0	6	3
9	L:L:H48	R:R:V283	13.84	Yes	No	2	6	4
10	L:L:H48	R:R:E287	4.92	Yes	Yes	2	6	5
11	L:L:F49	R:R:R30	8.55	No	No	0	3	2
12	L:L:F49	R:R:Y93	15.47	No	No	0	3	5
13	L:L:F49	R:R:D97	7.17	No	No	0	3	3
14	L:L:A50	R:R:D280	4.63	No	Yes	0	6	3
15	L:L:D52	R:R:Q25	9.14	No	No	0	5	3
16	L:L:D52	R:R:R30	11.91	No	No	0	5	2
17	L:L:C53	L:L:C77	7.28	No	No	0	9	9
18	L:L:C54	L:L:C93	7.28	No	No	0	9	9
19	L:L:T55	R:R:C24	5.07	Yes	No	1	5	9
20	L:L:T55	R:R:E272	5.64	Yes	No	1	5	4
21	L:L:T55	R:R:C273	6.76	Yes	No	1	5	8
22	L:L:K79	L:L:Y57	7.17	No	No	0	4	7
23	L:L:K95	L:L:Y57	5.97	No	No	0	6	7
24	L:L:Q60	L:L:S59	10.11	No	No	0	6	3
25	L:L:Q60	R:R:D20	3.92	No	No	0	6	3
26	L:L:P99	L:L:S61	7.13	No	No	0	3	5
27	L:L:I62	L:L:M67	7.29	Yes	No	0	8	8
28	L:L:F84	L:L:I62	8.79	No	Yes	0	8	8
29	L:L:C104	L:L:C64	7.28	No	No	8	6	6
30	L:L:L66	R:R:Y18	5.86	No	Yes	0	3	7
31	L:L:M67	R:R:Y18	9.58	No	Yes	0	8	7
32	L:L:K68	L:L:K87	11.49	No	No	0	4	7
33	L:L:S69	L:L:Y111	3.82	No	No	0	7	3
34	L:L:S69	R:R:F178	3.96	No	No	0	7	1
35	L:L:M105	L:L:Y70	9.58	No	Yes	0	6	8
36	L:L:P110	L:L:Y70	5.56	No	Yes	0	5	8
37	L:L:F71	L:L:I83	6.28	No	No	0	5	9
38	L:L:F71	R:R:Q175	11.71	No	No	0	5	2
39	L:L:F71	R:R:E177	16.32	No	No	0	5	1
40	L:L:E72	R:R:Q175	16.57	No	No	0	4	2
41	L:L:E72	R:R:H189	3.69	No	No	0	4	4
42	L:L:C77	L:L:T73	6.76	No	No	0	9	9
43	L:L:G81	L:L:T73	3.64	No	No	0	7	9
44	L:L:E76	L:L:S74	7.19	No	No	0	4	8
45	L:L:S74	R:R:S184	6.52	No	No	0	8	4
46	L:L:S75	R:R:F187	10.57	No	Yes	0	7	5
47	L:L:S78	R:R:R193	5.27	No	No	1	6	1
48	L:L:S78	R:R:Q265	5.78	No	No	1	6	2
49	L:L:S78	R:R:D266	10.31	No	Yes	1	6	3
50	L:L:P80	L:L:P96	3.9	No	No	9	8	9
51	L:L:P80	R:R:H189	6.1	No	No	9	8	4
52	L:L:F84	L:L:V82	9.18	No	No	0	8	9
53	L:L:I83	L:L:Q91	8.23	No	No	0	9	4
54	L:L:F84	L:L:V101	5.24	No	No	0	8	9
55	L:L:L85	R:R:F178	17.05	No	No	0	5	1
56	L:L:K88	L:L:T86	4.5	No	No	6	5	9
57	L:L:G89	L:L:T86	3.64	No	No	0	5	9
58	L:L:T86	R:R:Y18	7.49	No	Yes	6	9	7
59	L:L:K88	L:L:R90	11.14	No	No	6	5	5
60	L:L:K88	R:R:Y18	11.94	No	Yes	6	5	7
61	L:L:R90	R:R:Y18	16.46	No	Yes	6	5	7
62	L:L:R90	R:R:G19	4.5	No	No	0	5	3
63	L:L:Q91	R:R:P23	14.21	No	No	0	4	2
64	L:L:Q91	R:R:Q25	6.4	No	No	0	4	3
65	L:L:V92	R:R:Y18	3.79	No	Yes	0	7	7
66	L:L:C93	R:R:P23	5.65	No	No	0	9	2
67	L:L:K95	L:L:S97	6.12	No	No	0	6	4
68	L:L:P96	R:R:H189	9.15	No	No	9	9	4
69	L:L:G98	L:L:P99	4.06	No	No	0	4	3
70	L:L:G98	L:L:V101	3.68	No	No	0	4	9
71	L:L:M105	L:L:Q102	8.16	No	No	0	6	7
72	L:L:K107	L:L:L108	4.23	No	No	0	4	8
73	R:R:C24	R:R:C273	7.28	No	No	1	9	8
74	R:R:C24	R:R:R277	4.18	No	No	1	9	2
75	R:R:E29	R:R:K26	8.1	No	Yes	1	4	3
76	R:R:K26	R:R:R30	3.71	Yes	No	0	3	2
77	R:R:K26	R:R:R277	9.9	Yes	No	1	3	2
78	R:R:D280	R:R:K26	5.53	Yes	Yes	0	3	3
79	R:R:E29	R:R:R277	16.28	No	No	1	4	2
80	R:R:F32	R:R:L36	9.74	No	No	0	6	6
81	R:R:F32	R:R:L281	7.31	No	No	0	6	2
82	R:R:L37	R:R:Y41	8.21	Yes	Yes	2	5	7
83	R:R:K94	R:R:L37	7.05	Yes	Yes	2	4	5
84	R:R:L37	R:R:Q284	7.99	Yes	No	0	5	3
85	R:R:P38	R:R:P39	5.84	No	No	0	5	5
86	R:R:L95	R:R:P38	6.57	No	No	0	3	5
87	R:R:L40	R:R:V288	7.45	No	No	0	5	5
88	R:R:I91	R:R:Y41	6.04	No	Yes	0	7	7
89	R:R:K94	R:R:Y41	4.78	Yes	Yes	2	4	7
90	R:R:Y291	R:R:Y41	4.96	Yes	Yes	2	6	7
91	R:R:F45	R:R:L49	7.31	Yes	No	0	5	6
92	R:R:F45	R:R:L87	3.65	Yes	No	0	5	7
93	R:R:F45	R:R:P88	11.56	Yes	No	0	5	8
94	R:R:C295	R:R:G48	3.92	No	No	0	8	8
95	R:R:I53	R:R:L49	5.71	No	No	0	4	6
96	R:R:G51	R:R:P298	4.06	No	No	0	7	9
97	R:R:D80	R:R:N52	12.12	No	Yes	0	9	9
98	R:R:L81	R:R:N52	5.49	No	Yes	0	7	9
99	R:R:N52	R:R:P298	6.52	Yes	No	0	9	9
100	R:R:F308	R:R:V55	6.55	Yes	No	0	8	9
101	R:R:F308	R:R:V58	13.11	Yes	No	0	8	7
102	R:R:L59	R:R:Y62	8.21	No	Yes	0	7	4
103	R:R:L59	R:R:L73	6.92	No	No	0	7	8
104	R:R:L315	R:R:Q61	3.99	No	No	0	5	4
105	R:R:Q61	R:R:R318	5.84	No	No	0	4	5
106	R:R:K66	R:R:Y62	3.58	No	Yes	10	6	4
107	R:R:S70	R:R:Y62	6.36	No	Yes	10	8	4
108	R:R:Y311	R:R:Y62	9.93	No	Yes	0	4	4
109	R:R:L65	R:R:R307	4.86	No	No	0	7	6
110	R:R:K66	R:R:S70	4.59	No	No	10	6	8
111	R:R:I71	R:R:K66	5.82	No	No	0	6	6
112	R:R:N67	R:R:T69	4.39	No	No	5	7	8
113	R:R:N67	R:R:R145	7.23	No	Yes	5	7	7
114	R:R:M68	R:R:Y72	11.97	Yes	Yes	0	7	7
115	R:R:D130	R:R:M68	5.54	No	Yes	5	8	7
116	R:R:M68	R:R:R145	6.2	Yes	Yes	5	7	7
117	R:R:D130	R:R:T69	10.12	No	No	5	8	8
118	R:R:R145	R:R:T69	5.17	Yes	No	5	7	8
119	R:R:L126	R:R:Y72	16.41	No	Yes	0	7	7
120	R:R:G150	R:R:Y72	4.35	No	Yes	0	7	7
121	R:R:T153	R:R:Y72	6.24	No	Yes	0	5	7
122	R:R:F123	R:R:N75	12.08	Yes	No	4	7	9
123	R:R:N75	R:R:S154	8.94	No	No	4	9	7
124	R:R:N75	R:R:W158	5.65	No	Yes	4	9	9
125	R:R:L76	R:R:N297	10.98	No	Yes	0	9	9
126	R:R:S119	R:R:S79	6.52	Yes	No	4	7	8
127	R:R:S79	R:R:W158	6.18	No	Yes	4	8	9
128	R:R:D80	R:R:E120	10.39	No	Yes	3	9	9
129	R:R:D80	R:R:N297	8.08	No	Yes	3	9	9
130	R:R:F112	R:R:L82	8.53	No	No	0	5	6
131	R:R:F83	R:R:L87	4.87	Yes	No	0	6	7
132	R:R:F83	R:R:Y113	4.13	Yes	Yes	2	6	6
133	R:R:F83	R:R:Y291	13.41	Yes	Yes	2	6	6
134	R:R:C294	R:R:F83	6.98	No	Yes	0	9	6
135	R:R:F85	R:R:F89	5.36	No	No	0	5	6
136	R:R:F112	R:R:F85	6.43	No	No	0	5	5
137	R:R:T86	R:R:W90	4.85	No	Yes	0	6	6
138	R:R:F101	R:R:F89	10.72	Yes	No	0	7	6
139	R:R:F89	R:R:L109	8.53	No	No	0	6	5
140	R:R:W90	R:R:Y93	3.86	Yes	No	0	6	5
141	R:R:K94	R:R:W90	4.64	Yes	Yes	2	4	6
142	R:R:D92	R:R:K96	11.06	No	No	0	4	4
143	R:R:D92	R:R:F101	3.58	No	Yes	0	4	7
144	R:R:W99	R:R:Y93	12.54	Yes	No	0	8	5
145	R:R:D97	R:R:H180	3.78	No	Yes	0	3	1
146	R:R:D98	R:R:V100	4.38	No	No	0	4	3
147	R:R:F101	R:R:W99	21.05	Yes	Yes	0	7	8
148	R:R:C106	R:R:W99	9.14	No	Yes	11	9	8
149	R:R:C183	R:R:W99	11.75	No	Yes	11	9	8
150	R:R:F101	R:R:V100	5.24	Yes	No	0	7	3
151	R:R:F101	R:R:M105	6.22	Yes	No	0	7	6
152	R:R:D103	R:R:K107	6.91	No	No	0	3	7
153	R:R:D103	R:R:T174	5.78	No	No	0	3	5
154	R:R:L109	R:R:M105	5.65	No	No	0	5	6
155	R:R:C106	R:R:C183	5.46	No	No	11	9	9
156	R:R:F112	R:R:I108	5.02	No	No	0	5	5
157	R:R:S110	R:R:Y114	3.82	No	Yes	0	5	4
158	R:R:S110	R:R:S172	4.89	No	No	0	5	4
159	R:R:Y113	R:R:Y114	6.95	Yes	Yes	0	6	4
160	R:R:L117	R:R:Y113	11.72	No	Yes	0	7	6
161	R:R:Y113	R:R:Y255	3.97	Yes	Yes	0	6	6
162	R:R:Y113	R:R:Y291	9.93	Yes	Yes	2	6	6
163	R:R:S165	R:R:Y114	3.82	No	Yes	0	7	4
164	R:R:L185	R:R:Y114	4.69	No	Yes	0	4	4
165	R:R:Q199	R:R:Y114	6.76	No	Yes	0	5	4
166	R:R:F122	R:R:Y118	4.13	No	Yes	0	5	7
167	R:R:A164	R:R:Y118	6.67	No	Yes	0	5	7
168	R:R:K202	R:R:Y118	7.17	Yes	Yes	0	3	7
169	R:R:L203	R:R:Y118	5.86	No	Yes	0	4	7
170	R:R:S119	R:R:W158	6.18	Yes	Yes	4	7	9
171	R:R:E120	R:R:H293	3.69	Yes	Yes	3	9	9
172	R:R:C294	R:R:E120	7.6	No	Yes	0	9	9
173	R:R:E120	R:R:N297	6.57	Yes	Yes	3	9	9
174	R:R:I121	R:R:P211	5.08	No	Yes	0	8	9
175	R:R:F122	R:R:I157	5.02	No	No	0	5	7
176	R:R:F123	R:R:L126	3.65	Yes	No	4	7	7
177	R:R:F123	R:R:S154	5.28	Yes	No	4	7	7
178	R:R:F123	R:R:I157	8.79	Yes	No	4	7	7
179	R:R:F123	R:R:W158	11.02	Yes	Yes	4	7	9
180	R:R:I124	R:R:Y301	4.84	No	Yes	0	8	9
181	R:R:I125	R:R:P211	5.08	No	Yes	0	7	9
182	R:R:I125	R:R:V214	4.61	No	No	0	7	7
183	R:R:I157	R:R:L126	8.56	No	No	4	7	7
184	R:R:L127	R:R:Y301	4.69	No	Yes	0	9	9
185	R:R:M215	R:R:T128	4.52	No	No	3	8	9
186	R:R:T128	R:R:Y219	3.75	No	Yes	3	9	9
187	R:R:D130	R:R:R145	9.53	No	Yes	5	8	7
188	R:R:R131	R:R:Y219	6.17	No	Yes	0	9	9
189	R:R:R131	R:R:Y301	8.23	No	Yes	0	9	9
190	R:R:V136	R:R:Y132	12.62	No	No	12	8	8
191	R:R:H137	R:R:Y132	7.62	No	No	12	6	8
192	R:R:C218	R:R:Y132	8.06	No	No	0	8	8
193	R:R:A134	R:R:R145	6.91	No	Yes	0	8	7
194	R:R:H137	R:R:V136	9.69	No	No	12	6	8
195	R:R:I225	R:R:V136	4.61	No	No	0	5	8
196	R:R:F140	R:R:R143	10.69	No	No	0	5	4
197	R:R:A144	R:R:F140	4.16	No	No	0	4	5
198	R:R:A141	R:R:R145	4.15	No	Yes	0	5	7
199	R:R:T146	R:R:T148	4.71	No	No	5	7	3
200	R:R:F149	R:R:T146	9.08	No	No	5	4	7
201	R:R:F149	R:R:T148	3.89	No	No	5	4	3
202	R:R:P167	R:R:W195	5.4	No	Yes	0	7	1
203	R:R:K202	R:R:P167	5.02	Yes	No	0	3	7
204	R:R:F171	R:R:Y170	7.22	Yes	No	0	5	4
205	R:R:F171	R:R:F187	7.5	Yes	Yes	7	5	5
206	R:R:F171	R:R:P188	10.11	Yes	No	7	5	4
207	R:R:F171	R:R:W195	12.03	Yes	Yes	7	5	1
208	R:R:H186	R:R:K173	7.86	No	No	0	4	4
209	R:R:H181	R:R:T174	4.11	No	No	0	4	5
210	R:R:H186	R:R:Q175	13.6	No	No	0	4	2
211	R:R:H181	R:R:W176	7.41	No	No	0	4	2
212	R:R:E177	R:R:F178	13.99	No	No	0	1	1
213	R:R:E177	R:R:H180	6.15	No	Yes	0	1	1
214	R:R:H186	R:R:S184	5.58	No	No	0	4	4
215	R:R:F187	R:R:L185	6.09	Yes	No	0	5	4
216	R:R:F187	R:R:P188	4.33	Yes	No	7	5	4
217	R:R:F187	R:R:W195	12.03	Yes	Yes	7	5	1
218	R:R:E190	R:R:S191	4.31	No	No	0	4	5
219	R:R:F264	R:R:R193	4.28	No	No	0	4	1
220	R:R:D266	R:R:R193	11.91	Yes	No	1	3	1
221	R:R:L197	R:R:L201	5.54	No	No	0	1	4
222	R:R:F264	R:R:L197	3.65	No	No	0	4	1
223	R:R:F198	R:R:K202	13.65	No	Yes	0	4	3
224	R:R:K202	R:R:Q199	5.42	Yes	No	0	3	5
225	R:R:N204	R:R:N256	13.62	No	No	0	5	8
226	R:R:L260	R:R:N204	8.24	No	No	0	6	5
227	R:R:G207	R:R:P211	4.06	No	Yes	0	6	9
228	R:R:L208	R:R:T253	5.9	No	Yes	0	8	6
229	R:R:L208	R:R:N256	8.24	No	No	0	8	8
230	R:R:F248	R:R:P211	7.22	Yes	Yes	0	9	9
231	R:R:F248	R:R:L212	4.87	Yes	No	0	9	6
232	R:R:F249	R:R:L212	4.87	No	No	0	6	6
233	R:R:I217	R:R:L213	4.28	No	No	0	4	3
234	R:R:M215	R:R:Y219	4.79	No	Yes	3	8	9
235	R:R:F248	R:R:M215	4.98	Yes	No	3	9	8
236	R:R:I222	R:R:Y219	4.84	No	Yes	0	8	9
237	R:R:I241	R:R:Y219	12.09	No	Yes	0	7	9
238	R:R:M245	R:R:Y219	7.18	No	Yes	0	8	9
239	R:R:I223	R:R:V238	6.14	Yes	No	0	5	7
240	R:R:I223	R:R:I241	5.89	Yes	No	0	5	7
241	R:R:F242	R:R:I223	3.77	No	Yes	0	5	5
242	R:R:I225	R:R:R228	6.26	No	No	0	5	4
243	R:R:K234	R:R:L226	4.23	No	No	0	7	7
244	R:R:E306	R:R:K233	4.05	No	No	0	5	4
245	R:R:K236	R:R:R239	12.38	No	No	0	7	5
246	R:R:L240	R:R:V304	10.43	No	No	0	8	7
247	R:R:I244	R:R:I300	7.36	No	No	0	8	8
248	R:R:F251	R:R:I247	8.79	Yes	No	0	8	6
249	R:R:F248	R:R:W252	8.02	Yes	No	3	9	9
250	R:R:F248	R:R:H293	4.53	Yes	Yes	3	9	9
251	R:R:F249	R:R:L250	6.09	No	No	0	6	6
252	R:R:F249	R:R:T253	12.97	No	Yes	0	6	6
253	R:R:F251	R:R:I289	5.02	Yes	No	0	8	8
254	R:R:F251	R:R:H293	10.18	Yes	Yes	3	8	9
255	R:R:F251	R:R:V296	3.93	Yes	No	3	8	6
256	R:R:H293	R:R:W252	11.64	Yes	No	3	9	9
257	R:R:I259	R:R:Y255	8.46	No	Yes	0	5	6
258	R:R:E287	R:R:Y255	11.22	Yes	Yes	0	5	6
259	R:R:A290	R:R:Y255	5.34	No	Yes	0	7	6
260	R:R:T258	R:R:V283	4.76	No	No	0	4	4
261	R:R:T258	R:R:T286	7.85	No	No	0	4	7
262	R:R:I261	R:R:L279	5.71	No	Yes	0	5	4
263	R:R:F264	R:R:V263	7.87	No	No	0	4	5
264	R:R:E272	R:R:Q265	5.1	No	No	1	4	2
265	R:R:Q265	R:R:S276	7.22	No	No	1	2	3
266	R:R:D266	R:R:F267	15.52	Yes	No	0	3	1
267	R:R:F269	R:R:Q275	4.68	No	No	0	1	1
268	R:R:F269	R:R:L279	9.74	No	Yes	0	1	4
269	R:R:H271	R:R:T270	6.85	No	No	0	1	1
270	R:R:E272	R:R:S276	8.62	No	No	1	4	3
271	R:R:H278	R:R:Q275	6.18	No	No	0	3	1
272	R:R:E287	R:R:V283	4.28	Yes	No	2	5	4
273	R:R:E287	R:R:Y291	14.59	Yes	Yes	2	5	6
274	R:R:H293	R:R:V296	4.15	Yes	No	3	9	6
275	R:R:H293	R:R:N297	5.1	Yes	Yes	3	9	9
276	R:R:N297	R:R:Y301	4.65	Yes	Yes	0	9	9
277	R:R:F303	R:R:V299	6.55	No	No	0	7	6
278	R:R:I300	R:R:Y301	7.25	No	Yes	0	8	9
279	R:R:A302	R:R:F308	8.32	No	Yes	0	7	8
280	R:R:F303	R:R:F308	8.57	No	Yes	0	7	8
281	R:R:K310	R:R:Q314	4.07	No	No	0	5	4
282	L:L:L108	L:L:Y70	3.52	No	Yes	0	8	8
283	R:R:I78	R:R:W158	3.52	No	Yes	0	6	9
284	R:R:P23	R:R:T22	3.5	No	No	0	2	5
285	R:R:P254	R:R:T253	3.5	No	Yes	0	9	6
286	R:R:E306	R:R:R309	3.49	No	No	0	5	8
287	L:L:A51	L:L:S74	3.42	No	No	0	5	8
288	R:R:G33	R:R:L37	3.42	No	Yes	0	1	5
289	R:R:C295	R:R:V44	3.42	No	No	0	8	7
290	R:R:G48	R:R:L84	3.42	No	No	0	8	6
291	R:R:G111	R:R:L169	3.42	No	No	0	5	4
292	L:L:I62	L:L:P63	3.39	Yes	No	0	8	7
293	R:R:C106	R:R:T174	3.38	No	No	0	9	5
294	R:R:C218	R:R:T128	3.38	No	No	0	8	9
295	L:L:D103	L:L:G100	3.35	No	No	0	3	4
296	L:L:K109	L:L:P110	3.35	No	No	0	4	5
297	L:L:P80	R:R:L192	3.28	No	No	0	8	2
298	R:R:L210	R:R:P211	3.28	No	Yes	0	6	9
299	L:L:C64	L:L:I62	3.27	No	Yes	0	6	8
300	L:L:A94	L:L:I58	3.25	No	No	0	8	5
301	L:L:C64	L:L:K107	3.23	No	No	8	6	4
302	L:L:C104	L:L:K107	3.23	No	No	8	6	4
303	R:R:F122	R:R:F206	3.22	No	No	0	5	5
304	L:L:S56	L:L:T55	3.2	No	Yes	0	7	5
305	R:R:T292	R:R:V44	3.17	No	No	0	5	7
306	R:R:I71	R:R:S154	3.1	No	No	0	6	7
307	L:L:I58	L:L:V92	3.07	No	No	0	5	7
308	R:R:I47	R:R:V46	3.07	No	No	0	6	6
309	R:R:I71	R:R:V147	3.07	No	No	0	6	1
310	R:R:I129	R:R:V214	3.07	No	No	0	7	7
311	L:L:I83	L:L:T73	3.04	No	No	0	9	9
312	R:R:I162	R:R:T115	3.04	No	No	0	4	5
313	R:R:L169	R:R:S165	3	No	No	0	4	7
314	R:R:L73	R:R:V55	2.98	No	No	0	8	9
315	R:R:L74	R:R:V56	2.98	No	No	0	6	7
316	R:R:L312	R:R:V58	2.98	No	No	0	5	7
317	R:R:L74	R:R:V60	2.98	No	No	0	6	4
318	R:R:L205	R:R:V209	2.98	No	No	0	5	4
319	R:R:L281	R:R:V285	2.98	No	No	0	2	6
320	R:R:L82	R:R:T115	2.95	No	No	0	6	5
321	R:R:I135	R:R:I222	2.94	No	No	0	9	8
322	R:R:I216	R:R:M245	2.92	No	No	0	4	8
323	R:R:G168	R:R:Y114	2.9	No	Yes	0	5	4
324	R:R:E194	R:R:S191	2.87	No	No	0	1	5
325	R:R:I47	R:R:L43	2.85	No	No	0	6	5
326	R:R:I53	R:R:L57	2.85	No	No	0	4	4
327	R:R:I91	R:R:L95	2.85	No	No	0	7	3
328	R:R:I223	R:R:L227	2.85	Yes	No	0	5	4
329	R:R:I246	R:R:L250	2.85	No	No	0	5	6
330	R:R:I261	R:R:L268	2.85	No	No	0	5	1
331	R:R:K196	R:R:L192	2.82	No	No	0	4	2
332	R:R:K234	R:R:N231	2.8	No	No	0	7	3
333	L:L:K79	R:R:D266	2.77	No	Yes	0	4	3
334	R:R:L59	R:R:L74	2.77	No	No	0	7	6
335	R:R:L201	R:R:L205	2.77	No	No	0	4	5
336	R:R:H180	R:R:T182	2.74	Yes	No	0	1	3
337	R:R:D280	R:R:L279	2.71	Yes	Yes	0	3	4
338	R:R:L281	R:R:Q284	2.66	No	No	0	2	3
339	R:R:E29	R:R:N28	2.63	No	No	0	4	3
340	R:R:F45	R:R:V46	2.62	Yes	No	0	5	6
341	R:R:H137	R:R:L133	2.57	No	No	0	6	5
342	R:R:V288	R:R:Y41	2.52	No	Yes	0	5	7
343	R:R:F140	R:R:L133	2.44	No	No	0	5	5
344	L:L:K68	L:L:Y111	2.39	No	No	0	4	3
345	R:R:L65	R:R:Y311	2.34	No	No	0	7	4
346	R:R:H317	R:R:R313	2.26	No	No	0	5	5
347	L:L:E72	L:L:Y70	2.24	No	Yes	0	4	8
348	L:L:G100	L:L:P99	2.03	No	No	0	4	3
349	R:R:G116	R:R:S119	1.86	No	Yes	0	8	7
350	R:R:G51	R:R:V50	1.84	No	No	0	7	3
351	R:R:G305	R:R:V304	1.84	No	No	0	8	7
352	R:R:G221	R:R:T220	1.82	No	No	0	4	3
353	R:R:G102	R:R:M105	1.75	No	No	0	7	6
354	R:R:G221	R:R:K224	1.74	No	No	0	4	4
355	L:L:S56	R:R:A21	1.71	No	No	0	7	2
356	R:R:A161	R:R:S119	1.71	No	Yes	0	8	7
357	R:R:G48	R:R:N52	1.7	No	Yes	0	8	9
358	R:R:A77	R:R:V55	1.7	No	No	0	8	9
359	R:R:A77	R:R:V56	1.7	No	No	0	8	7
360	R:R:A200	R:R:V263	1.7	No	No	0	5	5
361	R:R:D17	R:R:G19	1.68	No	No	0	8	3
362	R:R:M166	R:R:P167	1.68	No	No	0	4	7
363	R:R:V147	R:R:V151	1.6	No	No	0	1	4
364	R:R:A237	R:R:L226	1.58	No	No	0	7	7
365	R:R:I155	R:R:V151	1.54	No	No	0	3	4
366	R:R:I247	R:R:V243	1.54	No	No	0	6	6
367	R:R:I300	R:R:V243	1.54	No	No	0	8	6
368	R:R:I152	R:R:T148	1.52	No	No	0	3	3
369	L:L:L66	L:L:S65	1.5	No	No	0	3	4
370	R:R:L43	R:R:S42	1.5	No	No	0	5	5
371	R:R:L279	R:R:S262	1.5	Yes	No	0	4	3
372	R:R:G305	R:R:R309	1.5	No	No	0	8	8
373	R:R:L54	R:R:V50	1.49	No	No	0	6	3
374	R:R:L226	R:R:V238	1.49	No	No	0	7	7
375	R:R:I152	R:R:I156	1.47	No	No	0	3	3
376	R:R:L257	R:R:T253	1.47	No	Yes	0	6	6
377	L:L:K106	L:L:M105	1.44	No	No	0	4	6
378	R:R:P230	R:R:R229	1.44	No	No	0	3	5
379	R:R:Q25	R:R:V27	1.43	No	No	0	3	1
380	R:R:I156	R:R:L160	1.43	No	No	0	3	4
381	R:R:I244	R:R:L240	1.43	No	No	0	8	8
382	R:R:L315	R:R:L57	1.38	No	No	0	5	4
383	R:R:H180	R:R:T179	1.37	Yes	No	0	1	5
384	R:R:R239	R:R:S235	1.32	No	No	0	5	5
385	R:R:E232	R:R:N231	1.31	No	No	0	4	3
386	R:R:F149	R:R:M68	1.24	No	Yes	5	4	7
387	R:R:S191	R:R:W195	1.24	No	Yes	0	5	1
388	R:R:L65	R:R:R64	1.21	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F47	11.1517	6	2	4
2	L:L:H48	7.4875	4	2	6
3	L:L:T55	5.1675	4	1	5
4	L:L:I62	5.685	4	0	8
5	L:L:Y70	5.225	4	0	8
6	R:R:Y18	9.18667	6	6	7
7	R:R:K26	6.81	4	1	3
8	R:R:L37	6.6675	4	2	5
9	R:R:Y41	5.79333	6	2	7
10	R:R:F45	6.285	4	0	5
11	R:R:N52	6.4575	4	0	9
12	R:R:Y62	7.02	4	10	4
13	R:R:M68	6.2375	4	5	7
14	R:R:Y72	9.7425	4	0	7
15	R:R:F83	7.3475	4	2	6
16	R:R:W90	11.105	4	2	6
17	R:R:K94	5.9775	4	2	4
18	R:R:W99	13.62	4	11	8
19	R:R:F101	9.362	5	0	7
20	R:R:Y113	7.66333	6	2	6
21	R:R:Y114	4.82333	6	0	4
22	R:R:Y118	5.9575	4	0	7
23	R:R:S119	4.0675	4	4	7
24	R:R:E120	7.0625	4	3	9
25	R:R:F123	8.164	5	4	7
26	R:R:R145	6.53167	6	5	7
27	R:R:W158	6.51	5	4	9
28	R:R:F171	9.215	4	7	5
29	R:R:H180	3.51	4	0	1
30	R:R:F187	8.104	5	7	5
31	R:R:W195	7.675	4	7	1
32	R:R:K202	7.815	4	0	3
33	R:R:P211	4.944	5	0	9
34	R:R:Y219	6.47	6	3	9
35	R:R:I223	4.6625	4	0	5
36	R:R:F248	5.924	5	3	9
37	R:R:F251	6.98	4	3	8
38	R:R:T253	5.96	4	0	6
39	R:R:Y255	7.2475	4	0	6
40	R:R:D266	10.1275	4	1	3
41	R:R:L279	4.915	4	0	4
42	R:R:D280	4.4775	4	0	3
43	R:R:E287	8.7525	4	2	5
44	R:R:Y291	10.022	5	2	6
45	R:R:H293	6.54833	6	3	9
46	R:R:N297	7.076	5	3	9
47	R:R:Y301	5.932	5	0	9
48	R:R:F308	9.1375	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E76	L:L:H48	43.2522	6.15	No	Yes	0	4	6
2	L:L:H48	R:R:E287	71.0773	4.92	Yes	Yes	2	6	5
3	R:R:E287	R:R:Y291	55.2844	14.59	Yes	Yes	2	5	6
4	L:L:F47	R:R:Y291	19.2519	7.22	Yes	Yes	2	4	6
5	L:L:H48	R:R:D280	37.4524	5.04	Yes	Yes	0	6	3
6	L:L:F47	R:R:W90	63.1131	31.07	Yes	Yes	2	4	6
7	R:R:W90	R:R:Y93	65.2084	3.86	Yes	No	0	6	5
8	L:L:F49	R:R:Y93	45.3169	15.47	No	No	0	3	5
9	L:L:F49	R:R:R30	24.3764	8.55	No	No	0	3	2
10	L:L:F49	R:R:D97	28.5543	7.17	No	No	0	3	3
11	L:L:D52	R:R:R30	22.4192	11.91	No	No	0	5	2
12	L:L:D52	R:R:Q25	21.0454	9.14	No	No	0	5	3
13	L:L:I83	L:L:T73	12.1933	3.04	No	No	0	9	9
14	L:L:F71	L:L:I83	11.7661	6.28	No	No	0	5	9
15	L:L:F71	R:R:E177	16.65	16.32	No	No	0	5	1
16	R:R:E177	R:R:H180	24.1794	6.15	No	Yes	0	1	1
17	R:R:D97	R:R:H180	27.449	3.78	No	Yes	0	3	1
18	L:L:I83	L:L:Q91	11.6688	8.23	No	No	0	9	4
19	L:L:Q91	R:R:Q25	18.3335	6.4	No	No	0	4	3
20	R:R:K26	R:R:R30	16.4761	3.71	Yes	No	0	3	2
21	R:R:K26	R:R:R277	32.2332	9.9	Yes	No	1	3	2
22	R:R:C24	R:R:R277	31.0666	4.18	No	No	1	9	2
23	L:L:T55	R:R:C24	28.4187	5.07	Yes	No	1	5	9
24	R:R:D280	R:R:K26	30.9822	5.53	Yes	Yes	0	3	3
25	L:L:T55	R:R:E272	24.5427	5.64	Yes	No	1	5	4
26	R:R:E272	R:R:Q265	21.8564	5.1	No	No	1	4	2
27	L:L:S78	R:R:Q265	20.5669	5.78	No	No	1	6	2
28	L:L:F71	R:R:Q175	15.6855	11.71	No	No	0	5	2
29	L:L:E72	R:R:Q175	48.3665	16.57	No	No	0	4	2
30	L:L:E72	L:L:Y70	41.4895	2.24	No	Yes	0	4	8
31	L:L:L108	L:L:Y70	34.3951	3.52	No	Yes	0	8	8
32	L:L:K107	L:L:L108	33.1875	4.23	No	No	0	4	8
33	L:L:C64	L:L:K107	30.6956	3.23	No	No	8	6	4
34	L:L:C64	L:L:I62	29.5341	3.27	No	Yes	0	6	8
35	L:L:F84	L:L:I62	10.5713	8.79	No	Yes	0	8	8
36	L:L:E76	L:L:S74	42.3568	7.19	No	No	0	4	8
37	L:L:S74	R:R:S184	40.6068	6.52	No	No	0	8	4
38	R:R:H186	R:R:S184	39.801	5.58	No	No	0	4	4
39	R:R:H186	R:R:Q175	38.4604	13.6	No	No	0	4	2
40	L:L:I62	L:L:M67	17.0261	7.29	Yes	No	0	8	8
41	L:L:M67	R:R:Y18	15.7444	9.58	No	Yes	0	8	7
42	L:L:F47	R:R:Y113	35.6512	9.28	Yes	Yes	2	4	6
43	R:R:Y113	R:R:Y114	81.7254	6.95	Yes	Yes	0	6	4
44	R:R:L185	R:R:Y114	10.5559	4.69	No	Yes	0	4	4
45	L:L:S78	R:R:R193	10.9883	5.27	No	No	1	6	1
46	L:L:F47	R:R:L87	25.8577	3.65	Yes	No	0	4	7
47	R:R:F45	R:R:L87	18.1697	3.65	Yes	No	0	5	7
48	R:R:F83	R:R:L87	24.1538	4.87	Yes	No	0	6	7
49	R:R:C294	R:R:F83	100	6.98	No	Yes	0	9	6
50	R:R:C294	R:R:E120	99.2095	7.6	No	Yes	0	9	9
51	R:R:D80	R:R:E120	13.6286	10.39	No	Yes	3	9	9
52	R:R:D80	R:R:N52	14.7159	12.12	No	Yes	0	9	9
53	R:R:F83	R:R:Y113	39.2509	4.13	Yes	Yes	2	6	6
54	R:R:F83	R:R:Y291	48.8526	13.41	Yes	Yes	2	6	6
55	R:R:Q199	R:R:Y114	65.6484	6.76	No	Yes	0	5	4
56	R:R:K202	R:R:Q199	64.7658	5.42	Yes	No	0	3	5
57	R:R:K202	R:R:Y118	62.6474	7.17	Yes	Yes	0	3	7
58	R:R:F122	R:R:Y118	59.823	4.13	No	Yes	0	5	7
59	R:R:F122	R:R:I157	57.9144	5.02	No	No	0	5	7
60	R:R:F123	R:R:I157	37.2323	8.79	Yes	No	4	7	7
61	R:R:F123	R:R:S154	30.1098	5.28	Yes	No	4	7	7
62	R:R:I71	R:R:S154	29.4599	3.1	No	No	0	6	7
63	R:R:I71	R:R:K66	24.9469	5.82	No	No	0	6	6
64	R:R:K66	R:R:Y62	22.6111	3.58	No	Yes	10	6	4
65	R:R:L59	R:R:Y62	16.8829	8.21	No	Yes	0	7	4
66	R:R:L59	R:R:L73	10.8988	6.92	No	No	0	7	8
67	R:R:I157	R:R:L126	19.7176	8.56	No	No	4	7	7
68	R:R:L126	R:R:Y72	20.1371	16.41	No	Yes	0	7	7
69	R:R:M68	R:R:Y72	16.6833	11.97	Yes	Yes	0	7	7
70	R:R:E120	R:R:N297	30.7954	6.57	Yes	Yes	3	9	9
71	R:R:W99	R:R:Y93	33.3998	12.54	Yes	No	0	8	5
72	R:R:F101	R:R:W99	22.5932	21.05	Yes	Yes	0	7	8
73	R:R:F101	R:R:F89	11.4335	10.72	Yes	No	0	7	6
74	R:R:Y113	R:R:Y255	20.4134	3.97	Yes	Yes	0	6	6
75	R:R:E120	R:R:H293	56.2566	3.69	Yes	Yes	3	9	9
76	R:R:F248	R:R:H293	51.0681	4.53	Yes	Yes	3	9	9
77	R:R:N297	R:R:Y301	30.7442	4.65	Yes	Yes	0	9	9
78	R:R:F248	R:R:M215	30.624	4.98	Yes	No	3	9	8
79	R:R:M215	R:R:T128	12.9148	4.52	No	No	3	8	9
80	R:R:M215	R:R:Y219	16.6961	4.79	No	Yes	3	8	9
81	R:R:R131	R:R:Y301	18.3002	8.23	No	Yes	0	9	9
82	R:R:R131	R:R:Y219	17.3715	6.17	No	Yes	0	9	9
83	R:R:C218	R:R:T128	12.8406	3.38	No	No	0	8	9
84	R:R:C218	R:R:Y132	11.5793	8.06	No	No	0	8	8
85	R:R:F248	R:R:L212	13.7028	4.87	Yes	No	0	9	6
86	R:R:F249	R:R:L212	12.4824	4.87	No	No	0	6	6
87	R:R:I241	R:R:Y219	22.6137	12.09	No	Yes	0	7	9
88	R:R:I223	R:R:I241	20.3751	5.89	Yes	No	0	5	7
89	R:R:I223	R:R:V238	13.6286	6.14	Yes	No	0	5	7
90	R:R:L226	R:R:V238	11.3695	1.49	No	No	0	7	7
91	R:R:I300	R:R:Y301	10.7581	7.25	No	Yes	0	8	9
92	R:R:Y113	R:R:Y291	21.5033	9.93	Yes	Yes	2	6	6
93	R:R:Y291	R:R:Y41	10.1159	4.96	Yes	Yes	2	6	7
94	R:R:E287	R:R:Y255	19.1777	11.22	Yes	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F47	R:R:Y41	8.25	2	Yes	Yes	4	7	0	1
L:L:F47	R:R:L87	3.65	2	Yes	No	4	7	0	1
L:L:F47	R:R:W90	31.07	2	Yes	Yes	4	6	0	1
L:L:F47	R:R:K94	7.44	2	Yes	Yes	4	4	0	1
L:L:F47	R:R:Y113	9.28	2	Yes	Yes	4	6	0	1
L:L:F47	R:R:Y291	7.22	2	Yes	Yes	4	6	0	1
L:L:H48	R:R:D280	5.04	2	Yes	Yes	6	3	0	1
L:L:H48	R:R:V283	13.84	2	Yes	No	6	4	0	1
L:L:H48	R:R:E287	4.92	2	Yes	Yes	6	5	0	1
L:L:F49	R:R:R30	8.55	0	No	No	3	2	0	1
L:L:F49	R:R:Y93	15.47	0	No	No	3	5	0	1
L:L:F49	R:R:D97	7.17	0	No	No	3	3	0	1
L:L:A50	R:R:D280	4.63	0	No	Yes	6	3	0	1
L:L:D52	R:R:Q25	9.14	0	No	No	5	3	0	1
L:L:D52	R:R:R30	11.91	0	No	No	5	2	0	1
L:L:T55	R:R:C24	5.07	1	Yes	No	5	9	0	1
L:L:T55	R:R:E272	5.64	1	Yes	No	5	4	0	1
L:L:T55	R:R:C273	6.76	1	Yes	No	5	8	0	1
L:L:Q60	R:R:D20	3.92	0	No	No	6	3	0	1
L:L:L66	R:R:Y18	5.86	0	No	Yes	3	7	0	1
L:L:M67	R:R:Y18	9.58	0	No	Yes	8	7	0	1
L:L:S69	R:R:F178	3.96	0	No	No	7	1	0	1
L:L:F71	R:R:Q175	11.71	0	No	No	5	2	0	1
L:L:F71	R:R:E177	16.32	0	No	No	5	1	0	1
L:L:E72	R:R:Q175	16.57	0	No	No	4	2	0	1
L:L:E72	R:R:H189	3.69	0	No	No	4	4	0	1
L:L:S74	R:R:S184	6.52	0	No	No	8	4	0	1
L:L:S75	R:R:F187	10.57	0	No	Yes	7	5	0	1
L:L:S78	R:R:R193	5.27	1	No	No	6	1	0	1
L:L:S78	R:R:Q265	5.78	1	No	No	6	2	0	1
L:L:S78	R:R:D266	10.31	1	No	Yes	6	3	0	1
L:L:P80	R:R:H189	6.1	9	No	No	8	4	0	1
L:L:L85	R:R:F178	17.05	0	No	No	5	1	0	1
L:L:T86	R:R:Y18	7.49	6	No	Yes	9	7	0	1
L:L:K88	R:R:Y18	11.94	6	No	Yes	5	7	0	1
L:L:R90	R:R:Y18	16.46	6	No	Yes	5	7	0	1
L:L:R90	R:R:G19	4.5	6	No	No	5	3	0	1
L:L:Q91	R:R:P23	14.21	0	No	No	4	2	0	1
L:L:Q91	R:R:Q25	6.4	0	No	No	4	3	0	1
L:L:V92	R:R:Y18	3.79	0	No	Yes	7	7	0	1
L:L:C93	R:R:P23	5.65	0	No	No	9	2	0	1
L:L:P96	R:R:H189	9.15	9	No	No	9	4	0	1
R:R:C24	R:R:C273	7.28	1	No	No	9	8	1	1
R:R:C24	R:R:R277	4.18	1	No	No	9	2	1	2
R:R:K26	R:R:R30	3.71	1	Yes	No	3	2	2	1
R:R:K26	R:R:R277	9.9	1	Yes	No	3	2	2	2
R:R:D280	R:R:K26	5.53	0	Yes	Yes	3	3	1	2
R:R:L37	R:R:Y41	8.21	2	Yes	Yes	5	7	2	1
R:R:K94	R:R:L37	7.05	2	Yes	Yes	4	5	1	2
R:R:I91	R:R:Y41	6.04	0	No	Yes	7	7	2	1
R:R:K94	R:R:Y41	4.78	2	Yes	Yes	4	7	1	1
R:R:Y291	R:R:Y41	4.96	2	Yes	Yes	6	7	1	1
R:R:F45	R:R:L87	3.65	0	Yes	No	5	7	2	1
R:R:F83	R:R:L87	4.87	2	Yes	No	6	7	2	1
R:R:F83	R:R:Y113	4.13	2	Yes	Yes	6	6	2	1
R:R:F83	R:R:Y291	13.41	2	Yes	Yes	6	6	2	1
R:R:T86	R:R:W90	4.85	0	No	Yes	6	6	2	1
R:R:W90	R:R:Y93	3.86	2	Yes	No	6	5	1	1
R:R:K94	R:R:W90	4.64	2	Yes	Yes	4	6	1	1
R:R:W99	R:R:Y93	12.54	11	Yes	No	8	5	2	1
R:R:D97	R:R:H180	3.78	0	No	Yes	3	1	1	2
R:R:Y113	R:R:Y114	6.95	2	Yes	Yes	6	4	1	2
R:R:L117	R:R:Y113	11.72	0	No	Yes	7	6	2	1
R:R:Y113	R:R:Y255	3.97	2	Yes	Yes	6	6	1	2
R:R:Y113	R:R:Y291	9.93	2	Yes	Yes	6	6	1	1
R:R:L185	R:R:Y114	4.69	0	No	Yes	4	4	2	2
R:R:F171	R:R:F187	7.5	7	Yes	Yes	5	5	2	1
R:R:F171	R:R:P188	10.11	7	Yes	No	5	4	2	2
R:R:F171	R:R:W195	12.03	7	Yes	Yes	5	1	2	2
R:R:H186	R:R:Q175	13.6	0	No	No	4	2	2	1
R:R:E177	R:R:F178	13.99	0	No	No	1	1	1	1
R:R:E177	R:R:H180	6.15	0	No	Yes	1	1	1	2
R:R:H186	R:R:S184	5.58	0	No	No	4	4	2	1
R:R:F187	R:R:L185	6.09	7	Yes	No	5	4	1	2
R:R:F187	R:R:P188	4.33	7	Yes	No	5	4	1	2
R:R:F187	R:R:W195	12.03	7	Yes	Yes	5	1	1	2
R:R:F264	R:R:R193	4.28	0	No	No	4	1	2	1
R:R:D266	R:R:R193	11.91	1	Yes	No	3	1	1	1
R:R:E287	R:R:Y255	11.22	2	Yes	Yes	5	6	1	2
R:R:T258	R:R:V283	4.76	0	No	No	4	4	2	1
R:R:E272	R:R:Q265	5.1	1	No	No	4	2	1	1
R:R:Q265	R:R:S276	7.22	1	No	No	2	3	1	2
R:R:D266	R:R:F267	15.52	1	Yes	No	3	1	1	2
R:R:E272	R:R:S276	8.62	1	No	No	4	3	1	2
R:R:E287	R:R:V283	4.28	2	Yes	No	5	4	1	1
R:R:E287	R:R:Y291	14.59	2	Yes	Yes	5	6	1	1
R:R:P23	R:R:T22	3.5	0	No	No	2	5	1	2
L:L:P80	R:R:L192	3.28	9	No	No	8	2	0	1
R:R:K196	R:R:L192	2.82	0	No	No	4	2	2	1
L:L:K79	R:R:D266	2.77	0	No	Yes	4	3	0	1
R:R:D280	R:R:L279	2.71	0	Yes	Yes	3	4	1	2
R:R:V288	R:R:Y41	2.52	0	No	Yes	5	7	2	1
L:L:S56	R:R:A21	1.71	0	No	No	7	2	0	1
R:R:D17	R:R:G19	1.68	0	No	No	8	3	2	1
R:R:Q25	R:R:V27	1.43	0	No	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VL9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.58
Number of Linked Nodes	354
Number of Links	388
Number of Hubs	48
Number of Links mediated by Hubs	180
Number of Communities	12
Number of Nodes involved in Communities	73
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	92178
Length Of Smallest Path	3
Average Path Length	16.4026
Length of Longest Path	38
Minimum Path Strength	1.45
Average Path Strength	7.2961
Maximum Path Strength	20.175
Minimum Path Correlation	0.7
Average Path Correlation	0.937971
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	52.7352
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3902
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Interleukin 8-like chemokines • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Interleukin 8-like chemokines • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	CCL15(26-92)
UniProt	Q16663
Sequence	>7VL9_nogp_Chain_L F H F A A D C C T S Y I S Q S I P C S L M K S Y F E T S S E C S K P G V I F L T K K G R Q V C A K P S G P G V Q D C M K K L K P Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P32246
Sequence	>7VL9_nogp_Chain_R D Y G D A T P C Q K V N E R A F G A Q L L P P L Y S L V F V I G L V G N I L V V L V L V Q Y K R L K N M T S I Y L L N L A I S D L L F L F T L P F W I D Y K L K D D W V F G D A M C K I L S G F Y Y T G L Y S E I F F I I L L T I D R Y L A I V H A V F A L R A R T V T F G V I T S I I I W A L A I L A S M P G L Y F S K T Q W E F T H H T C S L H F P H E S L R E W K L F Q A L K L N L F G L V L P L L V M I I C Y T G I I K I L L R R P N E K K S K A V R L I F V I M I I F F L F W T P Y N L T I L I S V F Q D F L F T H E C E Q S R H L D L A V Q V T E V I A Y T H C C V N P V I Y A F V G E R F R K Y L R Q L F H R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VL8	A	Protein	Chemokine	CCR1	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL8 (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	-	-		2.9	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL9	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(26-92)	-	Gi1/β1/γ2	2.6	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL9 (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(26-92)	-		2.6	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VLA	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(27-92)	-	Gi1/β1/γ2	2.7	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VLA (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(27-92)	-		2.7	2022-03-23	doi.org/10.1038/s41589-021-00918-z

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