psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F26	R:R:Y41	8.25	Yes	Yes	2	0	7
2	L:L:F26	R:R:L87	3.65	Yes	No	0	0	7
3	L:L:F26	R:R:W90	31.07	Yes	Yes	2	0	6
4	L:L:F26	R:R:K94	7.44	Yes	Yes	2	0	4
5	L:L:F26	R:R:Y113	9.28	Yes	Yes	2	0	6
6	L:L:F26	R:R:Y291	7.22	Yes	Yes	2	0	6
7	L:L:E55	L:L:H27	6.15	No	Yes	0	0	0
8	L:L:H27	R:R:D280	5.04	Yes	Yes	0	0	3
9	L:L:H27	R:R:V283	13.84	Yes	No	2	0	4
10	L:L:H27	R:R:E287	4.92	Yes	Yes	2	0	5
11	L:L:F28	R:R:R30	8.55	No	No	0	0	2
12	L:L:F28	R:R:Y93	15.47	No	No	0	0	5
13	L:L:F28	R:R:D97	7.17	No	No	0	0	3
14	L:L:A29	R:R:D280	4.63	No	Yes	0	0	3
15	L:L:D31	R:R:Q25	9.14	No	No	0	0	3
16	L:L:D31	R:R:R30	11.91	No	No	0	0	2
17	L:L:C32	L:L:C56	7.28	No	No	0	0	0
18	L:L:C33	L:L:C72	7.28	No	No	0	0	0
19	L:L:T34	R:R:C24	5.07	Yes	No	1	0	9
20	L:L:T34	R:R:E272	5.64	Yes	No	1	0	4
21	L:L:T34	R:R:C273	6.76	Yes	No	1	0	8
22	L:L:K58	L:L:Y36	7.17	No	No	0	0	0
23	L:L:K74	L:L:Y36	5.97	No	No	0	0	0
24	L:L:Q39	L:L:S38	10.11	No	No	0	0	0
25	L:L:Q39	R:R:D20	3.92	No	No	0	0	3
26	L:L:P78	L:L:S40	7.13	No	No	0	0	0
27	L:L:I41	L:L:M46	7.29	Yes	No	0	0	0
28	L:L:F63	L:L:I41	8.79	No	Yes	0	0	0
29	L:L:C43	L:L:C83	7.28	No	No	8	0	0
30	L:L:L45	R:R:Y18	5.86	No	Yes	0	0	7
31	L:L:M46	R:R:Y18	9.58	No	Yes	0	0	7
32	L:L:K47	L:L:K66	11.49	No	No	0	0	0
33	L:L:S48	L:L:Y90	3.82	No	No	0	0	0
34	L:L:S48	R:R:F178	3.96	No	No	0	0	1
35	L:L:M84	L:L:Y49	9.58	No	Yes	0	0	0
36	L:L:P89	L:L:Y49	5.56	No	Yes	0	0	0
37	L:L:F50	L:L:I62	6.28	No	No	0	0	0
38	L:L:F50	R:R:Q175	11.71	No	No	0	0	2
39	L:L:F50	R:R:E177	16.32	No	No	0	0	1
40	L:L:E51	R:R:Q175	16.57	No	No	0	0	2
41	L:L:E51	R:R:H189	3.69	No	No	0	0	4
42	L:L:C56	L:L:T52	6.76	No	No	0	0	0
43	L:L:G60	L:L:T52	3.64	No	No	0	0	0
44	L:L:E55	L:L:S53	7.19	No	No	0	0	0
45	L:L:S53	R:R:S184	6.52	No	No	0	0	4
46	L:L:S54	R:R:F187	10.57	No	Yes	0	0	5
47	L:L:S57	R:R:R193	5.27	No	No	1	0	1
48	L:L:S57	R:R:Q265	5.78	No	No	1	0	2
49	L:L:S57	R:R:D266	10.31	No	Yes	1	0	3
50	L:L:P59	L:L:P75	3.9	No	No	9	0	0
51	L:L:P59	R:R:H189	6.1	No	No	9	0	4
52	L:L:F63	L:L:V61	9.18	No	No	0	0	0
53	L:L:I62	L:L:Q70	8.23	No	No	0	0	0
54	L:L:F63	L:L:V80	5.24	No	No	0	0	0
55	L:L:L64	R:R:F178	17.05	No	No	0	0	1
56	L:L:K67	L:L:T65	4.5	No	No	6	0	0
57	L:L:G68	L:L:T65	3.64	No	No	0	0	0
58	L:L:T65	R:R:Y18	7.49	No	Yes	6	0	7
59	L:L:K67	L:L:R69	11.14	No	No	6	0	0
60	L:L:K67	R:R:Y18	11.94	No	Yes	6	0	7
61	L:L:R69	R:R:Y18	16.46	No	Yes	6	0	7
62	L:L:R69	R:R:G19	4.5	No	No	0	0	3
63	L:L:Q70	R:R:P23	14.21	No	No	0	0	2
64	L:L:Q70	R:R:Q25	6.4	No	No	0	0	3
65	L:L:V71	R:R:Y18	3.79	No	Yes	0	0	7
66	L:L:C72	R:R:P23	5.65	No	No	0	0	2
67	L:L:K74	L:L:S76	6.12	No	No	0	0	0
68	L:L:P75	R:R:H189	9.15	No	No	9	0	4
69	L:L:G77	L:L:P78	4.06	No	No	0	0	0
70	L:L:G77	L:L:V80	3.68	No	No	0	0	0
71	L:L:M84	L:L:Q81	8.16	No	No	0	0	0
72	L:L:K86	L:L:L87	4.23	No	No	0	0	0
73	R:R:C24	R:R:C273	7.28	No	No	1	9	8
74	R:R:C24	R:R:R277	4.18	No	No	1	9	2
75	R:R:E29	R:R:K26	8.1	No	Yes	1	4	3
76	R:R:K26	R:R:R30	3.71	Yes	No	0	3	2
77	R:R:K26	R:R:R277	9.9	Yes	No	1	3	2
78	R:R:D280	R:R:K26	5.53	Yes	Yes	0	3	3
79	R:R:E29	R:R:R277	16.28	No	No	1	4	2
80	R:R:F32	R:R:L36	9.74	No	No	0	6	6
81	R:R:F32	R:R:L281	7.31	No	No	0	6	2
82	R:R:L37	R:R:Y41	8.21	Yes	Yes	2	5	7
83	R:R:K94	R:R:L37	7.05	Yes	Yes	2	4	5
84	R:R:L37	R:R:Q284	7.99	Yes	No	0	5	3
85	R:R:P38	R:R:P39	5.84	No	No	0	5	5
86	R:R:L95	R:R:P38	6.57	No	No	0	3	5
87	R:R:L40	R:R:V288	7.45	No	No	0	5	5
88	R:R:I91	R:R:Y41	6.04	No	Yes	0	7	7
89	R:R:K94	R:R:Y41	4.78	Yes	Yes	2	4	7
90	R:R:Y291	R:R:Y41	4.96	Yes	Yes	2	6	7
91	R:R:F45	R:R:L49	7.31	Yes	No	0	5	6
92	R:R:F45	R:R:L87	3.65	Yes	No	0	5	7
93	R:R:F45	R:R:P88	11.56	Yes	No	0	5	8
94	R:R:C295	R:R:G48	3.92	No	No	0	8	8
95	R:R:I53	R:R:L49	5.71	No	No	0	4	6
96	R:R:G51	R:R:P298	4.06	No	No	0	7	9
97	R:R:D80	R:R:N52	12.12	No	Yes	0	9	9
98	R:R:L81	R:R:N52	5.49	No	Yes	0	7	9
99	R:R:N52	R:R:P298	6.52	Yes	No	0	9	9
100	R:R:F308	R:R:V55	6.55	Yes	No	0	8	9
101	R:R:F308	R:R:V58	13.11	Yes	No	0	8	7
102	R:R:L59	R:R:Y62	8.21	No	Yes	0	7	4
103	R:R:L59	R:R:L73	6.92	No	No	0	7	8
104	R:R:L315	R:R:Q61	3.99	No	No	0	5	4
105	R:R:Q61	R:R:R318	5.84	No	No	0	4	5
106	R:R:K66	R:R:Y62	3.58	No	Yes	10	6	4
107	R:R:S70	R:R:Y62	6.36	No	Yes	10	8	4
108	R:R:Y311	R:R:Y62	9.93	No	Yes	0	4	4
109	R:R:L65	R:R:R307	4.86	No	No	0	7	6
110	R:R:K66	R:R:S70	4.59	No	No	10	6	8
111	R:R:I71	R:R:K66	5.82	No	No	0	6	6
112	R:R:N67	R:R:T69	4.39	No	No	5	7	8
113	R:R:N67	R:R:R145	7.23	No	Yes	5	7	7
114	R:R:M68	R:R:Y72	11.97	Yes	Yes	0	7	7
115	R:R:D130	R:R:M68	5.54	No	Yes	5	8	7
116	R:R:M68	R:R:R145	6.2	Yes	Yes	5	7	7
117	R:R:D130	R:R:T69	10.12	No	No	5	8	8
118	R:R:R145	R:R:T69	5.17	Yes	No	5	7	8
119	R:R:L126	R:R:Y72	16.41	No	Yes	0	7	7
120	R:R:G150	R:R:Y72	4.35	No	Yes	0	7	7
121	R:R:T153	R:R:Y72	6.24	No	Yes	0	5	7
122	R:R:F123	R:R:N75	12.08	Yes	No	4	7	9
123	R:R:N75	R:R:S154	8.94	No	No	4	9	7
124	R:R:N75	R:R:W158	5.65	No	Yes	4	9	9
125	R:R:L76	R:R:N297	10.98	No	Yes	0	9	9
126	R:R:S119	R:R:S79	6.52	Yes	No	4	7	8
127	R:R:S79	R:R:W158	6.18	No	Yes	4	8	9
128	R:R:D80	R:R:E120	10.39	No	Yes	3	9	9
129	R:R:D80	R:R:N297	8.08	No	Yes	3	9	9
130	R:R:F112	R:R:L82	8.53	No	No	0	5	6
131	R:R:F83	R:R:L87	4.87	Yes	No	0	6	7
132	R:R:F83	R:R:Y113	4.13	Yes	Yes	2	6	6
133	R:R:F83	R:R:Y291	13.41	Yes	Yes	2	6	6
134	R:R:C294	R:R:F83	6.98	No	Yes	0	9	6
135	R:R:F85	R:R:F89	5.36	No	No	0	5	6
136	R:R:F112	R:R:F85	6.43	No	No	0	5	5
137	R:R:T86	R:R:W90	4.85	No	Yes	0	6	6
138	R:R:F101	R:R:F89	10.72	Yes	No	0	7	6
139	R:R:F89	R:R:L109	8.53	No	No	0	6	5
140	R:R:W90	R:R:Y93	3.86	Yes	No	0	6	5
141	R:R:K94	R:R:W90	4.64	Yes	Yes	2	4	6
142	R:R:D92	R:R:K96	11.06	No	No	0	4	4
143	R:R:D92	R:R:F101	3.58	No	Yes	0	4	7
144	R:R:W99	R:R:Y93	12.54	Yes	No	0	8	5
145	R:R:D97	R:R:H180	3.78	No	Yes	0	3	1
146	R:R:D98	R:R:V100	4.38	No	No	0	4	3
147	R:R:F101	R:R:W99	21.05	Yes	Yes	0	7	8
148	R:R:C106	R:R:W99	9.14	No	Yes	11	9	8
149	R:R:C183	R:R:W99	11.75	No	Yes	11	9	8
150	R:R:F101	R:R:V100	5.24	Yes	No	0	7	3
151	R:R:F101	R:R:M105	6.22	Yes	No	0	7	6
152	R:R:D103	R:R:K107	6.91	No	No	0	3	7
153	R:R:D103	R:R:T174	5.78	No	No	0	3	5
154	R:R:L109	R:R:M105	5.65	No	No	0	5	6
155	R:R:C106	R:R:C183	5.46	No	No	11	9	9
156	R:R:F112	R:R:I108	5.02	No	No	0	5	5
157	R:R:S110	R:R:Y114	3.82	No	Yes	0	5	4
158	R:R:S110	R:R:S172	4.89	No	No	0	5	4
159	R:R:Y113	R:R:Y114	6.95	Yes	Yes	0	6	4
160	R:R:L117	R:R:Y113	11.72	No	Yes	0	7	6
161	R:R:Y113	R:R:Y255	3.97	Yes	Yes	0	6	6
162	R:R:Y113	R:R:Y291	9.93	Yes	Yes	2	6	6
163	R:R:S165	R:R:Y114	3.82	No	Yes	0	7	4
164	R:R:L185	R:R:Y114	4.69	No	Yes	0	4	4
165	R:R:Q199	R:R:Y114	6.76	No	Yes	0	5	4
166	R:R:F122	R:R:Y118	4.13	No	Yes	0	5	7
167	R:R:A164	R:R:Y118	6.67	No	Yes	0	5	7
168	R:R:K202	R:R:Y118	7.17	Yes	Yes	0	3	7
169	R:R:L203	R:R:Y118	5.86	No	Yes	0	4	7
170	R:R:S119	R:R:W158	6.18	Yes	Yes	4	7	9
171	R:R:E120	R:R:H293	3.69	Yes	Yes	3	9	9
172	R:R:C294	R:R:E120	7.6	No	Yes	0	9	9
173	R:R:E120	R:R:N297	6.57	Yes	Yes	3	9	9
174	R:R:I121	R:R:P211	5.08	No	Yes	0	8	9
175	R:R:F122	R:R:I157	5.02	No	No	0	5	7
176	R:R:F123	R:R:L126	3.65	Yes	No	4	7	7
177	R:R:F123	R:R:S154	5.28	Yes	No	4	7	7
178	R:R:F123	R:R:I157	8.79	Yes	No	4	7	7
179	R:R:F123	R:R:W158	11.02	Yes	Yes	4	7	9
180	R:R:I124	R:R:Y301	4.84	No	Yes	0	8	9
181	R:R:I125	R:R:P211	5.08	No	Yes	0	7	9
182	R:R:I125	R:R:V214	4.61	No	No	0	7	7
183	R:R:I157	R:R:L126	8.56	No	No	4	7	7
184	R:R:L127	R:R:Y301	4.69	No	Yes	0	9	9
185	R:R:M215	R:R:T128	4.52	No	No	3	8	9
186	R:R:T128	R:R:Y219	3.75	No	Yes	3	9	9
187	R:R:D130	R:R:R145	9.53	No	Yes	5	8	7
188	R:R:R131	R:R:Y219	6.17	No	Yes	0	9	9
189	R:R:R131	R:R:Y301	8.23	No	Yes	0	9	9
190	R:R:V136	R:R:Y132	12.62	No	No	12	8	8
191	R:R:H137	R:R:Y132	7.62	No	No	12	6	8
192	R:R:C218	R:R:Y132	8.06	No	No	0	8	8
193	R:R:A134	R:R:R145	6.91	No	Yes	0	8	7
194	R:R:H137	R:R:V136	9.69	No	No	12	6	8
195	R:R:I225	R:R:V136	4.61	No	No	0	5	8
196	R:R:F140	R:R:R143	10.69	No	No	0	5	4
197	R:R:A144	R:R:F140	4.16	No	No	0	4	5
198	R:R:A141	R:R:R145	4.15	No	Yes	0	5	7
199	R:R:T146	R:R:T148	4.71	No	No	5	7	3
200	R:R:F149	R:R:T146	9.08	No	No	5	4	7
201	R:R:F149	R:R:T148	3.89	No	No	5	4	3
202	R:R:P167	R:R:W195	5.4	No	Yes	0	7	1
203	R:R:K202	R:R:P167	5.02	Yes	No	0	3	7
204	R:R:F171	R:R:Y170	7.22	Yes	No	0	5	4
205	R:R:F171	R:R:F187	7.5	Yes	Yes	7	5	5
206	R:R:F171	R:R:P188	10.11	Yes	No	7	5	4
207	R:R:F171	R:R:W195	12.03	Yes	Yes	7	5	1
208	R:R:H186	R:R:K173	7.86	No	No	0	4	4
209	R:R:H181	R:R:T174	4.11	No	No	0	4	5
210	R:R:H186	R:R:Q175	13.6	No	No	0	4	2
211	R:R:H181	R:R:W176	7.41	No	No	0	4	2
212	R:R:E177	R:R:F178	13.99	No	No	0	1	1
213	R:R:E177	R:R:H180	6.15	No	Yes	0	1	1
214	R:R:H186	R:R:S184	5.58	No	No	0	4	4
215	R:R:F187	R:R:L185	6.09	Yes	No	0	5	4
216	R:R:F187	R:R:P188	4.33	Yes	No	7	5	4
217	R:R:F187	R:R:W195	12.03	Yes	Yes	7	5	1
218	R:R:E190	R:R:S191	4.31	No	No	0	4	5
219	R:R:F264	R:R:R193	4.28	No	No	0	4	1
220	R:R:D266	R:R:R193	11.91	Yes	No	1	3	1
221	R:R:L197	R:R:L201	5.54	No	No	0	1	4
222	R:R:F264	R:R:L197	3.65	No	No	0	4	1
223	R:R:F198	R:R:K202	13.65	No	Yes	0	4	3
224	R:R:K202	R:R:Q199	5.42	Yes	No	0	3	5
225	R:R:N204	R:R:N256	13.62	No	No	0	5	8
226	R:R:L260	R:R:N204	8.24	No	No	0	6	5
227	R:R:G207	R:R:P211	4.06	No	Yes	0	6	9
228	R:R:L208	R:R:T253	5.9	No	Yes	0	8	6
229	R:R:L208	R:R:N256	8.24	No	No	0	8	8
230	R:R:F248	R:R:P211	7.22	Yes	Yes	0	9	9
231	R:R:F248	R:R:L212	4.87	Yes	No	0	9	6
232	R:R:F249	R:R:L212	4.87	No	No	0	6	6
233	R:R:I217	R:R:L213	4.28	No	No	0	4	3
234	R:R:M215	R:R:Y219	4.79	No	Yes	3	8	9
235	R:R:F248	R:R:M215	4.98	Yes	No	3	9	8
236	R:R:I222	R:R:Y219	4.84	No	Yes	0	8	9
237	R:R:I241	R:R:Y219	12.09	No	Yes	0	7	9
238	R:R:M245	R:R:Y219	7.18	No	Yes	0	8	9
239	R:R:I223	R:R:V238	6.14	Yes	No	0	5	7
240	R:R:I223	R:R:I241	5.89	Yes	No	0	5	7
241	R:R:F242	R:R:I223	3.77	No	Yes	0	5	5
242	R:R:I225	R:R:R228	6.26	No	No	0	5	4
243	R:R:K234	R:R:L226	4.23	No	No	0	7	7
244	R:R:E306	R:R:K233	4.05	No	No	0	5	4
245	R:R:K236	R:R:R239	12.38	No	No	0	7	5
246	R:R:L240	R:R:V304	10.43	No	No	0	8	7
247	R:R:I244	R:R:I300	7.36	No	No	0	8	8
248	R:R:F251	R:R:I247	8.79	Yes	No	0	8	6
249	R:R:F248	R:R:W252	8.02	Yes	No	3	9	9
250	R:R:F248	R:R:H293	4.53	Yes	Yes	3	9	9
251	R:R:F249	R:R:L250	6.09	No	No	0	6	6
252	R:R:F249	R:R:T253	12.97	No	Yes	0	6	6
253	R:R:F251	R:R:I289	5.02	Yes	No	0	8	8
254	R:R:F251	R:R:H293	10.18	Yes	Yes	3	8	9
255	R:R:F251	R:R:V296	3.93	Yes	No	3	8	6
256	R:R:H293	R:R:W252	11.64	Yes	No	3	9	9
257	R:R:I259	R:R:Y255	8.46	No	Yes	0	5	6
258	R:R:E287	R:R:Y255	11.22	Yes	Yes	0	5	6
259	R:R:A290	R:R:Y255	5.34	No	Yes	0	7	6
260	R:R:T258	R:R:V283	4.76	No	No	0	4	4
261	R:R:T258	R:R:T286	7.85	No	No	0	4	7
262	R:R:I261	R:R:L279	5.71	No	Yes	0	5	4
263	R:R:F264	R:R:V263	7.87	No	No	0	4	5
264	R:R:E272	R:R:Q265	5.1	No	No	1	4	2
265	R:R:Q265	R:R:S276	7.22	No	No	1	2	3
266	R:R:D266	R:R:F267	15.52	Yes	No	0	3	1
267	R:R:F269	R:R:Q275	4.68	No	No	0	1	1
268	R:R:F269	R:R:L279	9.74	No	Yes	0	1	4
269	R:R:H271	R:R:T270	6.85	No	No	0	1	1
270	R:R:E272	R:R:S276	8.62	No	No	1	4	3
271	R:R:H278	R:R:Q275	6.18	No	No	0	3	1
272	R:R:E287	R:R:V283	4.28	Yes	No	2	5	4
273	R:R:E287	R:R:Y291	14.59	Yes	Yes	2	5	6
274	R:R:H293	R:R:V296	4.15	Yes	No	3	9	6
275	R:R:H293	R:R:N297	5.1	Yes	Yes	3	9	9
276	R:R:N297	R:R:Y301	4.65	Yes	Yes	0	9	9
277	R:R:F303	R:R:V299	6.55	No	No	0	7	6
278	R:R:I300	R:R:Y301	7.25	No	Yes	0	8	9
279	R:R:A302	R:R:F308	8.32	No	Yes	0	7	8
280	R:R:F303	R:R:F308	8.57	No	Yes	0	7	8
281	R:R:K310	R:R:Q314	4.07	No	No	0	5	4
282	L:L:L87	L:L:Y49	3.52	No	Yes	0	0	0
283	R:R:I78	R:R:W158	3.52	No	Yes	0	6	9
284	R:R:P23	R:R:T22	3.5	No	No	0	2	5
285	R:R:P254	R:R:T253	3.5	No	Yes	0	9	6
286	R:R:E306	R:R:R309	3.49	No	No	0	5	8
287	L:L:A30	L:L:S53	3.42	No	No	0	0	0
288	R:R:G33	R:R:L37	3.42	No	Yes	0	1	5
289	R:R:C295	R:R:V44	3.42	No	No	0	8	7
290	R:R:G48	R:R:L84	3.42	No	No	0	8	6
291	R:R:G111	R:R:L169	3.42	No	No	0	5	4
292	L:L:I41	L:L:P42	3.39	Yes	No	0	0	0
293	R:R:C106	R:R:T174	3.38	No	No	0	9	5
294	R:R:C218	R:R:T128	3.38	No	No	0	8	9
295	L:L:D82	L:L:G79	3.35	No	No	0	0	0
296	L:L:K88	L:L:P89	3.35	No	No	0	0	0
297	L:L:P59	R:R:L192	3.28	No	No	0	0	2
298	R:R:L210	R:R:P211	3.28	No	Yes	0	6	9
299	L:L:C43	L:L:I41	3.27	No	Yes	0	0	0
300	L:L:A73	L:L:I37	3.25	No	No	0	0	0
301	L:L:C43	L:L:K86	3.23	No	No	8	0	0
302	L:L:C83	L:L:K86	3.23	No	No	8	0	0
303	R:R:F122	R:R:F206	3.22	No	No	0	5	5
304	L:L:S35	L:L:T34	3.2	No	Yes	0	0	0
305	R:R:T292	R:R:V44	3.17	No	No	0	5	7
306	R:R:I71	R:R:S154	3.1	No	No	0	6	7
307	L:L:I37	L:L:V71	3.07	No	No	0	0	0
308	R:R:I47	R:R:V46	3.07	No	No	0	6	6
309	R:R:I71	R:R:V147	3.07	No	No	0	6	1
310	R:R:I129	R:R:V214	3.07	No	No	0	7	7
311	L:L:I62	L:L:T52	3.04	No	No	0	0	0
312	R:R:I162	R:R:T115	3.04	No	No	0	4	5
313	R:R:L169	R:R:S165	3	No	No	0	4	7
314	R:R:L73	R:R:V55	2.98	No	No	0	8	9
315	R:R:L74	R:R:V56	2.98	No	No	0	6	7
316	R:R:L312	R:R:V58	2.98	No	No	0	5	7
317	R:R:L74	R:R:V60	2.98	No	No	0	6	4
318	R:R:L205	R:R:V209	2.98	No	No	0	5	4
319	R:R:L281	R:R:V285	2.98	No	No	0	2	6
320	R:R:L82	R:R:T115	2.95	No	No	0	6	5
321	R:R:I135	R:R:I222	2.94	No	No	0	9	8
322	R:R:I216	R:R:M245	2.92	No	No	0	4	8
323	R:R:G168	R:R:Y114	2.9	No	Yes	0	5	4
324	R:R:E194	R:R:S191	2.87	No	No	0	1	5
325	R:R:I47	R:R:L43	2.85	No	No	0	6	5
326	R:R:I53	R:R:L57	2.85	No	No	0	4	4
327	R:R:I91	R:R:L95	2.85	No	No	0	7	3
328	R:R:I223	R:R:L227	2.85	Yes	No	0	5	4
329	R:R:I246	R:R:L250	2.85	No	No	0	5	6
330	R:R:I261	R:R:L268	2.85	No	No	0	5	1
331	R:R:K196	R:R:L192	2.82	No	No	0	4	2
332	R:R:K234	R:R:N231	2.8	No	No	0	7	3
333	L:L:K58	R:R:D266	2.77	No	Yes	0	0	3
334	R:R:L59	R:R:L74	2.77	No	No	0	7	6
335	R:R:L201	R:R:L205	2.77	No	No	0	4	5
336	R:R:H180	R:R:T182	2.74	Yes	No	0	1	3
337	R:R:D280	R:R:L279	2.71	Yes	Yes	0	3	4
338	R:R:L281	R:R:Q284	2.66	No	No	0	2	3
339	R:R:E29	R:R:N28	2.63	No	No	0	4	3
340	R:R:F45	R:R:V46	2.62	Yes	No	0	5	6
341	R:R:H137	R:R:L133	2.57	No	No	0	6	5
342	R:R:V288	R:R:Y41	2.52	No	Yes	0	5	7
343	R:R:F140	R:R:L133	2.44	No	No	0	5	5
344	L:L:K47	L:L:Y90	2.39	No	No	0	0	0
345	R:R:L65	R:R:Y311	2.34	No	No	0	7	4
346	R:R:H317	R:R:R313	2.26	No	No	0	5	5
347	L:L:E51	L:L:Y49	2.24	No	Yes	0	0	0
348	L:L:G79	L:L:P78	2.03	No	No	0	0	0
349	R:R:G116	R:R:S119	1.86	No	Yes	0	8	7
350	R:R:G51	R:R:V50	1.84	No	No	0	7	3
351	R:R:G305	R:R:V304	1.84	No	No	0	8	7
352	R:R:G221	R:R:T220	1.82	No	No	0	4	3
353	R:R:G102	R:R:M105	1.75	No	No	0	7	6
354	R:R:G221	R:R:K224	1.74	No	No	0	4	4
355	L:L:S35	R:R:A21	1.71	No	No	0	0	2
356	R:R:A161	R:R:S119	1.71	No	Yes	0	8	7
357	R:R:G48	R:R:N52	1.7	No	Yes	0	8	9
358	R:R:A77	R:R:V55	1.7	No	No	0	8	9
359	R:R:A77	R:R:V56	1.7	No	No	0	8	7
360	R:R:A200	R:R:V263	1.7	No	No	0	5	5
361	R:R:D17	R:R:G19	1.68	No	No	0	8	3
362	R:R:M166	R:R:P167	1.68	No	No	0	4	7
363	R:R:V147	R:R:V151	1.6	No	No	0	1	4
364	R:R:A237	R:R:L226	1.58	No	No	0	7	7
365	R:R:I155	R:R:V151	1.54	No	No	0	3	4
366	R:R:I247	R:R:V243	1.54	No	No	0	6	6
367	R:R:I300	R:R:V243	1.54	No	No	0	8	6
368	R:R:I152	R:R:T148	1.52	No	No	0	3	3
369	L:L:L45	L:L:S44	1.5	No	No	0	0	0
370	R:R:L43	R:R:S42	1.5	No	No	0	5	5
371	R:R:L279	R:R:S262	1.5	Yes	No	0	4	3
372	R:R:G305	R:R:R309	1.5	No	No	0	8	8
373	R:R:L54	R:R:V50	1.49	No	No	0	6	3
374	R:R:L226	R:R:V238	1.49	No	No	0	7	7
375	R:R:I152	R:R:I156	1.47	No	No	0	3	3
376	R:R:L257	R:R:T253	1.47	No	Yes	0	6	6
377	L:L:K85	L:L:M84	1.44	No	No	0	0	0
378	R:R:P230	R:R:R229	1.44	No	No	0	3	5
379	R:R:Q25	R:R:V27	1.43	No	No	0	3	1
380	R:R:I156	R:R:L160	1.43	No	No	0	3	4
381	R:R:I244	R:R:L240	1.43	No	No	0	8	8
382	R:R:L315	R:R:L57	1.38	No	No	0	5	4
383	R:R:H180	R:R:T179	1.37	Yes	No	0	1	5
384	R:R:R239	R:R:S235	1.32	No	No	0	5	5
385	R:R:E232	R:R:N231	1.31	No	No	0	4	3
386	R:R:F149	R:R:M68	1.24	No	Yes	5	4	7
387	R:R:S191	R:R:W195	1.24	No	Yes	0	5	1
388	R:R:L65	R:R:R64	1.21	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F26	11.1517	6	2	0
2	L:L:H27	7.4875	4	2	0
3	L:L:T34	5.1675	4	1	0
4	L:L:I41	5.685	4	0	0
5	L:L:Y49	5.225	4	0	0
6	R:R:Y18	9.18667	6	6	7
7	R:R:K26	6.81	4	1	3
8	R:R:L37	6.6675	4	2	5
9	R:R:Y41	5.79333	6	2	7
10	R:R:F45	6.285	4	0	5
11	R:R:N52	6.4575	4	0	9
12	R:R:Y62	7.02	4	10	4
13	R:R:M68	6.2375	4	5	7
14	R:R:Y72	9.7425	4	0	7
15	R:R:F83	7.3475	4	2	6
16	R:R:W90	11.105	4	2	6
17	R:R:K94	5.9775	4	2	4
18	R:R:W99	13.62	4	11	8
19	R:R:F101	9.362	5	0	7
20	R:R:Y113	7.66333	6	2	6
21	R:R:Y114	4.82333	6	0	4
22	R:R:Y118	5.9575	4	0	7
23	R:R:S119	4.0675	4	4	7
24	R:R:E120	7.0625	4	3	9
25	R:R:F123	8.164	5	4	7
26	R:R:R145	6.53167	6	5	7
27	R:R:W158	6.51	5	4	9
28	R:R:F171	9.215	4	7	5
29	R:R:H180	3.51	4	0	1
30	R:R:F187	8.104	5	7	5
31	R:R:W195	7.675	4	7	1
32	R:R:K202	7.815	4	0	3
33	R:R:P211	4.944	5	0	9
34	R:R:Y219	6.47	6	3	9
35	R:R:I223	4.6625	4	0	5
36	R:R:F248	5.924	5	3	9
37	R:R:F251	6.98	4	3	8
38	R:R:T253	5.96	4	0	6
39	R:R:Y255	7.2475	4	0	6
40	R:R:D266	10.1275	4	1	3
41	R:R:L279	4.915	4	0	4
42	R:R:D280	4.4775	4	0	3
43	R:R:E287	8.7525	4	2	5
44	R:R:Y291	10.022	5	2	6
45	R:R:H293	6.54833	6	3	9
46	R:R:N297	7.076	5	3	9
47	R:R:Y301	5.932	5	0	9
48	R:R:F308	9.1375	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E55	L:L:H27	43.2522	6.15	No	Yes	0	0	0
2	L:L:H27	R:R:E287	71.0773	4.92	Yes	Yes	2	0	5
3	R:R:E287	R:R:Y291	55.2844	14.59	Yes	Yes	2	5	6
4	L:L:F26	R:R:Y291	19.2519	7.22	Yes	Yes	2	0	6
5	L:L:H27	R:R:D280	37.4524	5.04	Yes	Yes	0	0	3
6	L:L:F26	R:R:W90	63.1131	31.07	Yes	Yes	2	0	6
7	R:R:W90	R:R:Y93	65.2084	3.86	Yes	No	0	6	5
8	L:L:F28	R:R:Y93	45.3169	15.47	No	No	0	0	5
9	L:L:F28	R:R:R30	24.3764	8.55	No	No	0	0	2
10	L:L:F28	R:R:D97	28.5543	7.17	No	No	0	0	3
11	L:L:D31	R:R:R30	22.4192	11.91	No	No	0	0	2
12	L:L:D31	R:R:Q25	21.0454	9.14	No	No	0	0	3
13	L:L:I62	L:L:T52	12.1933	3.04	No	No	0	0	0
14	L:L:F50	L:L:I62	11.7661	6.28	No	No	0	0	0
15	L:L:F50	R:R:E177	16.65	16.32	No	No	0	0	1
16	R:R:E177	R:R:H180	24.1794	6.15	No	Yes	0	1	1
17	R:R:D97	R:R:H180	27.449	3.78	No	Yes	0	3	1
18	L:L:I62	L:L:Q70	11.6688	8.23	No	No	0	0	0
19	L:L:Q70	R:R:Q25	18.3335	6.4	No	No	0	0	3
20	R:R:K26	R:R:R30	16.4761	3.71	Yes	No	0	3	2
21	R:R:K26	R:R:R277	32.2332	9.9	Yes	No	1	3	2
22	R:R:C24	R:R:R277	31.0666	4.18	No	No	1	9	2
23	L:L:T34	R:R:C24	28.4187	5.07	Yes	No	1	0	9
24	R:R:D280	R:R:K26	30.9822	5.53	Yes	Yes	0	3	3
25	L:L:T34	R:R:E272	24.5427	5.64	Yes	No	1	0	4
26	R:R:E272	R:R:Q265	21.8564	5.1	No	No	1	4	2
27	L:L:S57	R:R:Q265	20.5669	5.78	No	No	1	0	2
28	L:L:F50	R:R:Q175	15.6855	11.71	No	No	0	0	2
29	L:L:E51	R:R:Q175	48.3665	16.57	No	No	0	0	2
30	L:L:E51	L:L:Y49	41.4895	2.24	No	Yes	0	0	0
31	L:L:L87	L:L:Y49	34.3951	3.52	No	Yes	0	0	0
32	L:L:K86	L:L:L87	33.1875	4.23	No	No	0	0	0
33	L:L:C43	L:L:K86	30.6956	3.23	No	No	8	0	0
34	L:L:C43	L:L:I41	29.5341	3.27	No	Yes	0	0	0
35	L:L:F63	L:L:I41	10.5713	8.79	No	Yes	0	0	0
36	L:L:E55	L:L:S53	42.3568	7.19	No	No	0	0	0
37	L:L:S53	R:R:S184	40.6068	6.52	No	No	0	0	4
38	R:R:H186	R:R:S184	39.801	5.58	No	No	0	4	4
39	R:R:H186	R:R:Q175	38.4604	13.6	No	No	0	4	2
40	L:L:I41	L:L:M46	17.0261	7.29	Yes	No	0	0	0
41	L:L:M46	R:R:Y18	15.7444	9.58	No	Yes	0	0	7
42	L:L:F26	R:R:Y113	35.6512	9.28	Yes	Yes	2	0	6
43	R:R:Y113	R:R:Y114	81.7254	6.95	Yes	Yes	0	6	4
44	R:R:L185	R:R:Y114	10.5559	4.69	No	Yes	0	4	4
45	L:L:S57	R:R:R193	10.9883	5.27	No	No	1	0	1
46	L:L:F26	R:R:L87	25.8577	3.65	Yes	No	0	0	7
47	R:R:F45	R:R:L87	18.1697	3.65	Yes	No	0	5	7
48	R:R:F83	R:R:L87	24.1538	4.87	Yes	No	0	6	7
49	R:R:C294	R:R:F83	100	6.98	No	Yes	0	9	6
50	R:R:C294	R:R:E120	99.2095	7.6	No	Yes	0	9	9
51	R:R:D80	R:R:E120	13.6286	10.39	No	Yes	3	9	9
52	R:R:D80	R:R:N52	14.7159	12.12	No	Yes	0	9	9
53	R:R:F83	R:R:Y113	39.2509	4.13	Yes	Yes	2	6	6
54	R:R:F83	R:R:Y291	48.8526	13.41	Yes	Yes	2	6	6
55	R:R:Q199	R:R:Y114	65.6484	6.76	No	Yes	0	5	4
56	R:R:K202	R:R:Q199	64.7658	5.42	Yes	No	0	3	5
57	R:R:K202	R:R:Y118	62.6474	7.17	Yes	Yes	0	3	7
58	R:R:F122	R:R:Y118	59.823	4.13	No	Yes	0	5	7
59	R:R:F122	R:R:I157	57.9144	5.02	No	No	0	5	7
60	R:R:F123	R:R:I157	37.2323	8.79	Yes	No	4	7	7
61	R:R:F123	R:R:S154	30.1098	5.28	Yes	No	4	7	7
62	R:R:I71	R:R:S154	29.4599	3.1	No	No	0	6	7
63	R:R:I71	R:R:K66	24.9469	5.82	No	No	0	6	6
64	R:R:K66	R:R:Y62	22.6111	3.58	No	Yes	10	6	4
65	R:R:L59	R:R:Y62	16.8829	8.21	No	Yes	0	7	4
66	R:R:L59	R:R:L73	10.8988	6.92	No	No	0	7	8
67	R:R:I157	R:R:L126	19.7176	8.56	No	No	4	7	7
68	R:R:L126	R:R:Y72	20.1371	16.41	No	Yes	0	7	7
69	R:R:M68	R:R:Y72	16.6833	11.97	Yes	Yes	0	7	7
70	R:R:E120	R:R:N297	30.7954	6.57	Yes	Yes	3	9	9
71	R:R:W99	R:R:Y93	33.3998	12.54	Yes	No	0	8	5
72	R:R:F101	R:R:W99	22.5932	21.05	Yes	Yes	0	7	8
73	R:R:F101	R:R:F89	11.4335	10.72	Yes	No	0	7	6
74	R:R:Y113	R:R:Y255	20.4134	3.97	Yes	Yes	0	6	6
75	R:R:E120	R:R:H293	56.2566	3.69	Yes	Yes	3	9	9
76	R:R:F248	R:R:H293	51.0681	4.53	Yes	Yes	3	9	9
77	R:R:N297	R:R:Y301	30.7442	4.65	Yes	Yes	0	9	9
78	R:R:F248	R:R:M215	30.624	4.98	Yes	No	3	9	8
79	R:R:M215	R:R:T128	12.9148	4.52	No	No	3	8	9
80	R:R:M215	R:R:Y219	16.6961	4.79	No	Yes	3	8	9
81	R:R:R131	R:R:Y301	18.3002	8.23	No	Yes	0	9	9
82	R:R:R131	R:R:Y219	17.3715	6.17	No	Yes	0	9	9
83	R:R:C218	R:R:T128	12.8406	3.38	No	No	0	8	9
84	R:R:C218	R:R:Y132	11.5793	8.06	No	No	0	8	8
85	R:R:F248	R:R:L212	13.7028	4.87	Yes	No	0	9	6
86	R:R:F249	R:R:L212	12.4824	4.87	No	No	0	6	6
87	R:R:I241	R:R:Y219	22.6137	12.09	No	Yes	0	7	9
88	R:R:I223	R:R:I241	20.3751	5.89	Yes	No	0	5	7
89	R:R:I223	R:R:V238	13.6286	6.14	Yes	No	0	5	7
90	R:R:L226	R:R:V238	11.3695	1.49	No	No	0	7	7
91	R:R:I300	R:R:Y301	10.7581	7.25	No	Yes	0	8	9
92	R:R:Y113	R:R:Y291	21.5033	9.93	Yes	Yes	2	6	6
93	R:R:Y291	R:R:Y41	10.1159	4.96	Yes	Yes	2	6	7
94	R:R:E287	R:R:Y255	19.1777	11.22	Yes	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F26	R:R:Y41	8.25	2	Yes	Yes	0	7	0	1
L:L:F26	R:R:L87	3.65	2	Yes	No	0	7	0	1
L:L:F26	R:R:W90	31.07	2	Yes	Yes	0	6	0	1
L:L:F26	R:R:K94	7.44	2	Yes	Yes	0	4	0	1
L:L:F26	R:R:Y113	9.28	2	Yes	Yes	0	6	0	1
L:L:F26	R:R:Y291	7.22	2	Yes	Yes	0	6	0	1
L:L:H27	R:R:D280	5.04	2	Yes	Yes	0	3	0	1
L:L:H27	R:R:V283	13.84	2	Yes	No	0	4	0	1
L:L:H27	R:R:E287	4.92	2	Yes	Yes	0	5	0	1
L:L:F28	R:R:R30	8.55	0	No	No	0	2	0	1
L:L:F28	R:R:Y93	15.47	0	No	No	0	5	0	1
L:L:F28	R:R:D97	7.17	0	No	No	0	3	0	1
L:L:A29	R:R:D280	4.63	0	No	Yes	0	3	0	1
L:L:D31	R:R:Q25	9.14	0	No	No	0	3	0	1
L:L:D31	R:R:R30	11.91	0	No	No	0	2	0	1
L:L:T34	R:R:C24	5.07	1	Yes	No	0	9	0	1
L:L:T34	R:R:E272	5.64	1	Yes	No	0	4	0	1
L:L:T34	R:R:C273	6.76	1	Yes	No	0	8	0	1
L:L:Q39	R:R:D20	3.92	0	No	No	0	3	0	1
L:L:L45	R:R:Y18	5.86	0	No	Yes	0	7	0	1
L:L:M46	R:R:Y18	9.58	0	No	Yes	0	7	0	1
L:L:S48	R:R:F178	3.96	0	No	No	0	1	0	1
L:L:F50	R:R:Q175	11.71	0	No	No	0	2	0	1
L:L:F50	R:R:E177	16.32	0	No	No	0	1	0	1
L:L:E51	R:R:Q175	16.57	0	No	No	0	2	0	1
L:L:E51	R:R:H189	3.69	0	No	No	0	4	0	1
L:L:S53	R:R:S184	6.52	0	No	No	0	4	0	1
L:L:S54	R:R:F187	10.57	0	No	Yes	0	5	0	1
L:L:S57	R:R:R193	5.27	1	No	No	0	1	0	1
L:L:S57	R:R:Q265	5.78	1	No	No	0	2	0	1
L:L:S57	R:R:D266	10.31	1	No	Yes	0	3	0	1
L:L:P59	R:R:H189	6.1	9	No	No	0	4	0	1
L:L:L64	R:R:F178	17.05	0	No	No	0	1	0	1
L:L:T65	R:R:Y18	7.49	6	No	Yes	0	7	0	1
L:L:K67	R:R:Y18	11.94	6	No	Yes	0	7	0	1
L:L:R69	R:R:Y18	16.46	6	No	Yes	0	7	0	1
L:L:R69	R:R:G19	4.5	6	No	No	0	3	0	1
L:L:Q70	R:R:P23	14.21	0	No	No	0	2	0	1
L:L:Q70	R:R:Q25	6.4	0	No	No	0	3	0	1
L:L:V71	R:R:Y18	3.79	0	No	Yes	0	7	0	1
L:L:C72	R:R:P23	5.65	0	No	No	0	2	0	1
L:L:P75	R:R:H189	9.15	9	No	No	0	4	0	1
R:R:C24	R:R:C273	7.28	1	No	No	9	8	1	1
R:R:C24	R:R:R277	4.18	1	No	No	9	2	1	2
R:R:K26	R:R:R30	3.71	1	Yes	No	3	2	2	1
R:R:K26	R:R:R277	9.9	1	Yes	No	3	2	2	2
R:R:D280	R:R:K26	5.53	0	Yes	Yes	3	3	1	2
R:R:L37	R:R:Y41	8.21	2	Yes	Yes	5	7	2	1
R:R:K94	R:R:L37	7.05	2	Yes	Yes	4	5	1	2
R:R:I91	R:R:Y41	6.04	0	No	Yes	7	7	2	1
R:R:K94	R:R:Y41	4.78	2	Yes	Yes	4	7	1	1
R:R:Y291	R:R:Y41	4.96	2	Yes	Yes	6	7	1	1
R:R:F45	R:R:L87	3.65	0	Yes	No	5	7	2	1
R:R:F83	R:R:L87	4.87	2	Yes	No	6	7	2	1
R:R:F83	R:R:Y113	4.13	2	Yes	Yes	6	6	2	1
R:R:F83	R:R:Y291	13.41	2	Yes	Yes	6	6	2	1
R:R:T86	R:R:W90	4.85	0	No	Yes	6	6	2	1
R:R:W90	R:R:Y93	3.86	2	Yes	No	6	5	1	1
R:R:K94	R:R:W90	4.64	2	Yes	Yes	4	6	1	1
R:R:W99	R:R:Y93	12.54	11	Yes	No	8	5	2	1
R:R:D97	R:R:H180	3.78	0	No	Yes	3	1	1	2
R:R:Y113	R:R:Y114	6.95	2	Yes	Yes	6	4	1	2
R:R:L117	R:R:Y113	11.72	0	No	Yes	7	6	2	1
R:R:Y113	R:R:Y255	3.97	2	Yes	Yes	6	6	1	2
R:R:Y113	R:R:Y291	9.93	2	Yes	Yes	6	6	1	1
R:R:L185	R:R:Y114	4.69	0	No	Yes	4	4	2	2
R:R:F171	R:R:F187	7.5	7	Yes	Yes	5	5	2	1
R:R:F171	R:R:P188	10.11	7	Yes	No	5	4	2	2
R:R:F171	R:R:W195	12.03	7	Yes	Yes	5	1	2	2
R:R:H186	R:R:Q175	13.6	0	No	No	4	2	2	1
R:R:E177	R:R:F178	13.99	0	No	No	1	1	1	1
R:R:E177	R:R:H180	6.15	0	No	Yes	1	1	1	2
R:R:H186	R:R:S184	5.58	0	No	No	4	4	2	1
R:R:F187	R:R:L185	6.09	7	Yes	No	5	4	1	2
R:R:F187	R:R:P188	4.33	7	Yes	No	5	4	1	2
R:R:F187	R:R:W195	12.03	7	Yes	Yes	5	1	1	2
R:R:F264	R:R:R193	4.28	0	No	No	4	1	2	1
R:R:D266	R:R:R193	11.91	1	Yes	No	3	1	1	1
R:R:E287	R:R:Y255	11.22	2	Yes	Yes	5	6	1	2
R:R:T258	R:R:V283	4.76	0	No	No	4	4	2	1
R:R:E272	R:R:Q265	5.1	1	No	No	4	2	1	1
R:R:Q265	R:R:S276	7.22	1	No	No	2	3	1	2
R:R:D266	R:R:F267	15.52	1	Yes	No	3	1	1	2
R:R:E272	R:R:S276	8.62	1	No	No	4	3	1	2
R:R:E287	R:R:V283	4.28	2	Yes	No	5	4	1	1
R:R:E287	R:R:Y291	14.59	2	Yes	Yes	5	6	1	1
R:R:P23	R:R:T22	3.5	0	No	No	2	5	1	2
L:L:P59	R:R:L192	3.28	9	No	No	0	2	0	1
R:R:K196	R:R:L192	2.82	0	No	No	4	2	2	1
L:L:K58	R:R:D266	2.77	0	No	Yes	0	3	0	1
R:R:D280	R:R:L279	2.71	0	Yes	Yes	3	4	1	2
R:R:V288	R:R:Y41	2.52	0	No	Yes	5	7	2	1
L:L:S35	R:R:A21	1.71	0	No	No	0	2	0	1
R:R:D17	R:R:G19	1.68	0	No	No	8	3	2	1
R:R:Q25	R:R:V27	1.43	0	No	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VL9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.58
Number of Linked Nodes	354
Number of Links	388
Number of Hubs	48
Number of Links mediated by Hubs	180
Number of Communities	12
Number of Nodes involved in Communities	73
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	92178
Length Of Smallest Path	3
Average Path Length	16.4026
Length of Longest Path	38
Minimum Path Strength	1.45
Average Path Strength	7.2961
Maximum Path Strength	20.175
Minimum Path Correlation	0.7
Average Path Correlation	0.937971
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	52.7352
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3902
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular function activator activity • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • chemoattractant activity • CCR chemokine receptor binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • chemotaxis • taxis • response to external stimulus • locomotion • cell chemotaxis • cell migration • cell motility • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response • immune response • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • immune system process • response to external biotic stimulus • positive regulation of locomotion • regulation of cell motility • positive regulation of biological process • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • inflammatory response • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • phospholipase activity • lipase activity • C-C chemokine binding • chemokine binding • chemokine (C-C motif) ligand 7 binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine (C-C motif) ligand 5 binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • calcium-mediated signaling • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • mononuclear cell migration • leukocyte chemotaxis • monocyte chemotaxis • myeloid leukocyte migration • positive regulation of monocyte chemotaxis • regulation of response to external stimulus • positive regulation of chemotaxis • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • response to wounding • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • cell adhesion • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of cellular process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of macromolecule metabolic process • secretion by cell • exocytosis • secretion • export from cell • vesicle-mediated transport • regulation of developmental process • negative regulation of biomineral tissue development • regulation of biomineral tissue development • regulation of bone mineralization • negative regulation of bone mineralization • ossification • biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • negative regulation of developmental process • bone mineralization • tissue development • negative regulation of ossification • negative regulation of multicellular organismal process • regulation of ossification • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • cell development • regulation of cell differentiation • positive regulation of osteoclast differentiation • regulation of cell development • positive regulation of developmental process • regulation of osteoclast differentiation • positive regulation of cell differentiation • positive regulation of hemopoiesis • cell differentiation • osteoclast differentiation • hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell development • regulation of myeloid leukocyte differentiation • positive regulation of myeloid leukocyte differentiation • myeloid cell differentiation • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of multicellular organismal process • positive regulation of leukocyte differentiation • leukocyte differentiation • cell surface • external side of plasma membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32246
Sequence	>7VL9_nogp_Chain_R D Y G D A T P C Q K V N E R A F G A Q L L P P L Y S L V F V I G L V G N I L V V L V L V Q Y K R L K N M T S I Y L L N L A I S D L L F L F T L P F W I D Y K L K D D W V F G D A M C K I L S G F Y Y T G L Y S E I F F I I L L T I D R Y L A I V H A V F A L R A R T V T F G V I T S I I I W A L A I L A S M P G L Y F S K T Q W E F T H H T C S L H F P H E S L R E W K L F Q A L K L N L F G L V L P L L V M I I C Y T G I I K I L L R R P N E K K S K A V R L I F V I M I I F F L F W T P Y N L T I L I S V F Q D F L F T H E C E Q S R H L D L A V Q V T E V I A Y T H C C V N P V I Y A F V G E R F R K Y L R Q L F H R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VL8	A	Protein	Chemokine	CCR1	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL8 (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	-	-		2.9	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL9	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(26-92)	-	Gi1/β1/γ2	2.6	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL9 (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(26-92)	-		2.6	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VLA	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(27-92)	-	Gi1/β1/γ2	2.7	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VLA (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(27-92)	-		2.7	2022-03-23	doi.org/10.1038/s41589-021-00918-z

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