psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E55	L:L:H27	8.62	No	Yes	0	0	0
2	L:L:H27	R:R:D280	7.56	Yes	No	0	0	3
3	L:L:H27	R:R:V283	11.07	Yes	No	0	0	4
4	L:L:H27	R:R:Q284	6.18	Yes	No	0	0	3
5	L:L:F28	R:R:R30	6.41	Yes	No	0	0	2
6	L:L:F28	R:R:Y93	20.63	Yes	No	0	0	5
7	L:L:F28	R:R:K94	8.69	Yes	No	0	0	4
8	L:L:F28	R:R:D97	7.17	Yes	No	0	0	3
9	L:L:A29	R:R:D280	4.63	No	No	0	0	3
10	L:L:A30	L:L:E55	4.53	No	No	0	0	0
11	L:L:D31	R:R:Q25	10.44	No	No	0	0	3
12	L:L:D31	R:R:R30	11.91	No	No	0	0	2
13	L:L:C32	L:L:C56	7.28	No	No	0	0	0
14	L:L:C33	L:L:C72	7.28	No	No	0	0	0
15	L:L:C33	R:R:P23	7.53	No	No	0	0	2
16	L:L:T34	R:R:C273	6.76	No	No	0	0	8
17	L:L:K58	L:L:Y36	15.53	No	No	0	0	0
18	L:L:K74	L:L:Y36	14.33	No	No	0	0	0
19	L:L:I37	L:L:Q39	5.49	No	No	0	0	0
20	L:L:I37	L:L:I41	5.89	No	No	0	0	0
21	L:L:I37	R:R:D20	13.99	No	No	0	0	3
22	L:L:Q39	R:R:D17	7.83	No	No	0	0	8
23	L:L:P78	L:L:S40	5.34	No	No	0	0	0
24	L:L:I41	L:L:V71	4.61	No	No	0	0	0
25	L:L:C43	L:L:C83	7.28	No	No	0	0	0
26	L:L:L45	L:L:S44	4.5	No	No	0	0	0
27	L:L:F63	L:L:M46	3.73	Yes	No	0	0	0
28	L:L:L87	L:L:M46	4.24	No	No	0	0	0
29	L:L:K47	L:L:L64	4.23	No	No	0	0	0
30	L:L:K47	L:L:K66	5.75	No	No	0	0	0
31	L:L:S48	R:R:F178	3.96	No	No	0	0	1
32	L:L:M84	L:L:Y49	13.17	No	No	0	0	0
33	L:L:F50	L:L:I62	6.28	No	No	0	0	0
34	L:L:F50	R:R:Q175	18.74	No	Yes	0	0	2
35	L:L:F50	R:R:E177	17.49	No	No	0	0	1
36	L:L:E51	R:R:Q175	5.1	No	Yes	4	0	2
37	L:L:E51	R:R:H186	9.85	No	Yes	4	0	4
38	L:L:E51	R:R:H189	8.62	No	No	0	0	4
39	L:L:G60	L:L:T52	5.46	No	No	0	0	0
40	L:L:E55	L:L:S53	10.06	No	No	0	0	0
41	L:L:S54	R:R:F187	6.61	No	Yes	0	0	5
42	L:L:S54	R:R:K196	4.59	No	No	0	0	4
43	L:L:S57	R:R:R193	5.27	Yes	No	9	0	1
44	L:L:S57	R:R:Q265	5.78	Yes	No	0	0	2
45	L:L:S57	R:R:D266	5.89	Yes	No	9	0	3
46	L:L:P59	L:L:P75	5.84	No	Yes	0	0	0
47	L:L:P59	R:R:L192	6.57	No	No	0	0	2
48	L:L:G60	L:L:P75	4.06	No	Yes	0	0	0
49	L:L:F63	L:L:V61	7.87	Yes	No	0	0	0
50	L:L:I62	L:L:Q70	5.49	No	No	0	0	0
51	L:L:F63	L:L:V71	3.93	Yes	No	0	0	0
52	L:L:F63	L:L:V80	5.24	Yes	No	0	0	0
53	L:L:L64	R:R:F178	9.74	No	No	0	0	1
54	L:L:K67	L:L:T65	4.5	No	No	5	0	0
55	L:L:T65	R:R:Y18	9.99	No	Yes	5	0	7
56	L:L:K67	L:L:R69	4.95	No	Yes	5	0	0
57	L:L:K67	R:R:Y18	8.36	No	Yes	5	0	7
58	L:L:R69	R:R:Y18	4.12	Yes	Yes	5	0	7
59	L:L:R69	R:R:T22	6.47	Yes	No	0	0	5
60	L:L:Q70	R:R:P23	4.74	No	No	0	0	2
61	L:L:Q70	R:R:Q25	5.12	No	No	0	0	3
62	L:L:V71	R:R:Y18	8.83	No	Yes	0	0	7
63	L:L:P75	R:R:H189	10.68	Yes	No	0	0	4
64	L:L:S76	R:R:E190	4.31	No	No	0	0	4
65	L:L:G77	L:L:P78	4.06	No	No	0	0	0
66	L:L:M84	L:L:Q81	4.08	No	No	0	0	0
67	L:L:C83	L:L:K86	6.47	No	No	0	0	0
68	R:R:C24	R:R:C273	7.28	No	No	7	9	8
69	R:R:K26	R:R:R277	7.43	Yes	No	0	3	2
70	R:R:D280	R:R:K26	4.15	No	Yes	0	3	3
71	R:R:R30	R:R:V27	3.92	No	No	0	2	1
72	R:R:E29	R:R:R277	8.14	No	No	0	4	2
73	R:R:E29	R:R:L281	3.98	No	No	0	4	2
74	R:R:F32	R:R:L36	12.18	No	No	0	6	6
75	R:R:F32	R:R:L281	4.87	No	No	0	6	2
76	R:R:L37	R:R:Y41	8.21	No	Yes	0	5	7
77	R:R:L37	R:R:Q284	7.99	No	No	0	5	3
78	R:R:P38	R:R:P39	5.84	No	No	0	5	5
79	R:R:L95	R:R:P38	6.57	No	No	0	3	5
80	R:R:L87	R:R:Y41	10.55	Yes	Yes	0	7	7
81	R:R:I91	R:R:Y41	4.84	No	Yes	0	7	7
82	R:R:V288	R:R:Y41	3.79	No	Yes	0	5	7
83	R:R:F45	R:R:L49	8.53	No	No	0	5	6
84	R:R:F45	R:R:P88	7.22	No	No	0	5	8
85	R:R:C295	R:R:I47	4.91	No	No	0	8	6
86	R:R:C295	R:R:G48	3.92	No	No	0	8	8
87	R:R:I53	R:R:L49	5.71	No	No	0	4	6
88	R:R:D80	R:R:N52	10.77	Yes	No	0	9	9
89	R:R:N52	R:R:P298	9.77	No	No	0	9	9
90	R:R:L312	R:R:L54	4.15	No	No	0	5	6
91	R:R:L74	R:R:V56	4.47	No	No	0	6	7
92	R:R:F308	R:R:V58	10.49	No	No	0	8	7
93	R:R:L59	R:R:Y62	9.38	No	Yes	0	7	4
94	R:R:L59	R:R:L73	6.92	No	No	0	7	8
95	R:R:Q61	R:R:Y311	20.29	No	No	6	4	4
96	R:R:L315	R:R:Q61	9.32	No	No	6	5	4
97	R:R:Q61	R:R:R318	9.35	No	Yes	6	4	5
98	R:R:L65	R:R:Y62	4.69	No	Yes	0	7	4
99	R:R:S70	R:R:Y62	10.17	No	Yes	0	8	4
100	R:R:Y311	R:R:Y62	9.93	No	Yes	0	4	4
101	R:R:N67	R:R:T69	5.85	No	No	2	7	8
102	R:R:N67	R:R:S70	4.47	No	No	0	7	8
103	R:R:N67	R:R:R145	6.03	No	Yes	2	7	7
104	R:R:M68	R:R:Y72	11.97	No	Yes	2	7	7
105	R:R:D130	R:R:M68	8.32	Yes	No	2	8	7
106	R:R:M68	R:R:R145	4.96	No	Yes	2	7	7
107	R:R:D130	R:R:T69	10.12	Yes	No	2	8	8
108	R:R:R145	R:R:T69	5.17	Yes	No	2	7	8
109	R:R:L126	R:R:Y72	17.58	No	Yes	0	7	7
110	R:R:D130	R:R:Y72	5.75	Yes	Yes	2	8	7
111	R:R:G150	R:R:Y72	4.35	No	Yes	0	7	7
112	R:R:T153	R:R:Y72	6.24	No	Yes	0	5	7
113	R:R:F123	R:R:N75	14.5	Yes	No	3	7	9
114	R:R:N75	R:R:S154	7.45	No	No	3	9	7
115	R:R:N75	R:R:W158	4.52	No	Yes	3	9	9
116	R:R:D80	R:R:L76	4.07	Yes	No	0	9	9
117	R:R:I124	R:R:L76	4.28	Yes	No	0	8	9
118	R:R:S119	R:R:S79	6.52	Yes	No	3	7	8
119	R:R:S79	R:R:W158	3.71	No	Yes	3	8	9
120	R:R:D80	R:R:E120	7.8	Yes	Yes	1	9	9
121	R:R:C294	R:R:D80	9.34	Yes	Yes	1	9	9
122	R:R:D80	R:R:N297	6.73	Yes	Yes	1	9	9
123	R:R:F83	R:R:Y113	7.22	No	Yes	1	6	6
124	R:R:F83	R:R:Y291	20.63	No	Yes	1	6	6
125	R:R:C294	R:R:F83	6.98	Yes	No	1	9	6
126	R:R:C294	R:R:L84	4.76	Yes	No	0	9	6
127	R:R:F85	R:R:F89	6.43	No	No	0	5	6
128	R:R:F112	R:R:F85	4.29	No	No	0	5	5
129	R:R:T86	R:R:W90	4.85	No	No	0	6	6
130	R:R:T86	R:R:Y113	3.75	No	Yes	0	6	6
131	R:R:L87	R:R:Y291	11.72	Yes	Yes	0	7	6
132	R:R:F101	R:R:F89	7.5	Yes	No	0	7	6
133	R:R:F89	R:R:L109	13.4	No	No	0	6	5
134	R:R:W90	R:R:Y93	3.86	No	No	0	6	5
135	R:R:D92	R:R:K96	11.06	No	No	0	4	4
136	R:R:W99	R:R:Y93	10.61	Yes	No	0	8	5
137	R:R:D98	R:R:K96	5.53	No	No	0	4	4
138	R:R:D98	R:R:V100	4.38	No	No	0	4	3
139	R:R:F101	R:R:W99	16.04	Yes	Yes	0	7	8
140	R:R:C106	R:R:W99	9.14	No	Yes	10	9	8
141	R:R:C183	R:R:W99	11.75	No	Yes	10	9	8
142	R:R:F101	R:R:V100	5.24	Yes	No	0	7	3
143	R:R:F101	R:R:M105	7.46	Yes	No	0	7	6
144	R:R:D103	R:R:K107	8.3	No	No	0	3	7
145	R:R:D103	R:R:K173	4.15	No	No	0	3	4
146	R:R:L109	R:R:M105	5.65	No	No	0	5	6
147	R:R:C106	R:R:T174	5.07	No	No	0	9	5
148	R:R:C106	R:R:C183	7.28	No	No	10	9	9
149	R:R:S110	R:R:S172	6.52	No	No	0	5	4
150	R:R:G111	R:R:L169	5.13	No	No	0	5	4
151	R:R:Y113	R:R:Y114	13.9	Yes	No	0	6	4
152	R:R:Y113	R:R:Y255	3.97	Yes	Yes	1	6	6
153	R:R:E287	R:R:Y113	5.61	No	Yes	1	5	6
154	R:R:Y113	R:R:Y291	3.97	Yes	Yes	1	6	6
155	R:R:Q199	R:R:Y114	4.51	No	No	0	5	4
156	R:R:I162	R:R:T115	4.56	No	No	0	4	5
157	R:R:S165	R:R:T115	4.8	No	No	0	7	5
158	R:R:F122	R:R:Y118	4.13	No	Yes	0	5	7
159	R:R:A164	R:R:Y118	4	No	Yes	0	5	7
160	R:R:K202	R:R:Y118	8.36	No	Yes	0	3	7
161	R:R:L203	R:R:Y118	5.86	No	Yes	0	4	7
162	R:R:S119	R:R:W158	6.18	Yes	Yes	3	7	9
163	R:R:E120	R:R:I124	4.1	Yes	Yes	1	9	8
164	R:R:E120	R:R:W252	6.54	Yes	Yes	1	9	9
165	R:R:E120	R:R:H293	6.15	Yes	Yes	1	9	9
166	R:R:C294	R:R:E120	4.56	Yes	Yes	1	9	9
167	R:R:E120	R:R:N297	5.26	Yes	Yes	1	9	9
168	R:R:F122	R:R:I157	5.02	No	Yes	0	5	7
169	R:R:F123	R:R:S154	3.96	Yes	No	3	7	7
170	R:R:F123	R:R:I157	10.05	Yes	Yes	0	7	7
171	R:R:F123	R:R:W158	12.03	Yes	Yes	3	7	9
172	R:R:I124	R:R:N297	4.25	Yes	Yes	1	8	9
173	R:R:I124	R:R:Y301	8.46	Yes	Yes	1	8	9
174	R:R:I125	R:R:P211	8.47	No	Yes	0	7	9
175	R:R:I157	R:R:L126	5.71	Yes	No	0	7	7
176	R:R:T128	R:R:Y219	3.75	No	Yes	0	9	9
177	R:R:D130	R:R:R145	10.72	Yes	Yes	2	8	7
178	R:R:R131	R:R:Y219	7.2	No	Yes	0	9	9
179	R:R:I244	R:R:R131	3.76	No	No	0	8	9
180	R:R:R131	R:R:Y301	4.12	No	Yes	0	9	9
181	R:R:V136	R:R:Y132	12.62	Yes	No	11	8	8
182	R:R:H137	R:R:Y132	8.71	No	No	11	6	8
183	R:R:C218	R:R:Y132	8.06	No	No	0	8	8
184	R:R:A134	R:R:R145	5.53	No	Yes	0	8	7
185	R:R:H137	R:R:V136	5.54	No	Yes	11	6	8
186	R:R:I225	R:R:V136	4.61	No	Yes	0	5	8
187	R:R:F140	R:R:R143	4.28	No	No	0	5	4
188	R:R:A144	R:R:F140	4.16	No	No	0	4	5
189	R:R:F149	R:R:T146	9.08	No	No	0	4	7
190	R:R:F171	R:R:Y170	9.28	No	No	0	5	4
191	R:R:F171	R:R:F187	8.57	No	Yes	8	5	5
192	R:R:F171	R:R:P188	7.22	No	No	8	5	4
193	R:R:K173	R:R:Q175	4.07	No	Yes	4	4	2
194	R:R:H186	R:R:K173	18.34	Yes	No	4	4	4
195	R:R:H181	R:R:T174	4.11	No	No	0	4	5
196	R:R:H186	R:R:Q175	7.42	Yes	Yes	4	4	2
197	R:R:F178	R:R:W176	4.01	No	No	0	1	2
198	R:R:H181	R:R:W176	8.46	No	No	0	4	2
199	R:R:E177	R:R:H180	8.62	No	No	0	1	1
200	R:R:H186	R:R:S184	6.97	Yes	No	0	4	4
201	R:R:F187	R:R:L185	4.87	Yes	No	0	5	4
202	R:R:F187	R:R:P188	4.33	Yes	No	8	5	4
203	R:R:F187	R:R:W195	5.01	Yes	No	0	5	1
204	R:R:F187	R:R:Q199	4.68	Yes	No	0	5	5
205	R:R:E190	R:R:H189	4.92	No	No	0	4	4
206	R:R:E194	R:R:S191	5.75	No	No	0	1	5
207	R:R:S191	R:R:W195	7.41	No	No	0	5	1
208	R:R:D266	R:R:R193	9.53	No	No	9	3	1
209	R:R:F267	R:R:R193	6.41	No	No	0	1	1
210	R:R:L197	R:R:L201	4.15	No	No	0	1	4
211	R:R:F264	R:R:L197	3.65	No	No	0	4	1
212	R:R:F198	R:R:K202	4.96	No	No	0	4	3
213	R:R:L203	R:R:N256	6.87	No	No	0	4	8
214	R:R:N204	R:R:N256	6.81	No	No	0	5	8
215	R:R:L260	R:R:N204	5.49	No	No	0	6	5
216	R:R:G207	R:R:P211	4.06	No	Yes	0	6	9
217	R:R:L208	R:R:T253	4.42	No	Yes	0	8	6
218	R:R:L208	R:R:N256	10.98	No	No	0	8	8
219	R:R:F248	R:R:P211	4.33	Yes	Yes	0	9	9
220	R:R:F248	R:R:L212	4.87	Yes	No	0	9	6
221	R:R:F249	R:R:L212	3.65	No	No	0	6	6
222	R:R:M215	R:R:Y219	4.79	No	Yes	0	8	9
223	R:R:F248	R:R:M215	8.71	Yes	No	0	9	8
224	R:R:I222	R:R:Y219	4.84	No	Yes	0	8	9
225	R:R:I241	R:R:Y219	13.3	No	Yes	0	7	9
226	R:R:M245	R:R:Y219	7.18	No	Yes	0	8	9
227	R:R:I223	R:R:V238	4.61	No	No	0	5	7
228	R:R:I223	R:R:I241	5.89	No	No	0	5	7
229	R:R:F242	R:R:I223	3.77	No	No	0	5	5
230	R:R:K234	R:R:L226	4.23	No	No	0	7	7
231	R:R:L226	R:R:V238	4.47	No	No	0	7	7
232	R:R:K234	R:R:N231	5.6	No	No	0	7	3
233	R:R:E232	R:R:K233	5.4	No	No	0	4	4
234	R:R:L240	R:R:V304	5.96	No	No	0	8	7
235	R:R:F242	R:R:M245	3.73	No	No	0	5	8
236	R:R:I244	R:R:I300	7.36	No	No	0	8	8
237	R:R:F251	R:R:I247	5.02	Yes	No	0	8	6
238	R:R:F248	R:R:W252	10.02	Yes	Yes	1	9	9
239	R:R:F248	R:R:H293	4.53	Yes	Yes	1	9	9
240	R:R:F249	R:R:L250	6.09	No	No	0	6	6
241	R:R:F249	R:R:T253	10.38	No	Yes	0	6	6
242	R:R:F251	R:R:T292	3.89	Yes	No	0	8	5
243	R:R:F251	R:R:H293	4.53	Yes	Yes	0	8	9
244	R:R:F251	R:R:V296	3.93	Yes	No	0	8	6
245	R:R:A290	R:R:W252	3.89	No	Yes	0	7	9
246	R:R:H293	R:R:W252	16.93	Yes	Yes	1	9	9
247	R:R:P254	R:R:T253	5.25	No	Yes	0	9	6
248	R:R:I259	R:R:Y255	10.88	No	Yes	0	5	6
249	R:R:T286	R:R:Y255	7.49	No	Yes	0	7	6
250	R:R:E287	R:R:Y255	11.22	No	Yes	1	5	6
251	R:R:A290	R:R:Y255	4	No	Yes	0	7	6
252	R:R:T258	R:R:T286	10.99	No	No	0	4	7
253	R:R:F264	R:R:V263	6.55	No	No	0	4	5
254	R:R:Q265	R:R:S276	4.33	No	No	0	2	3
255	R:R:L279	R:R:Q265	3.99	Yes	No	0	4	2
256	R:R:E272	R:R:F269	7	No	Yes	0	4	1
257	R:R:F269	R:R:L279	7.31	Yes	Yes	0	1	4
258	R:R:H271	R:R:T270	13.69	No	No	0	1	1
259	R:R:H271	R:R:Q275	11.13	No	No	0	1	1
260	R:R:E274	R:R:Q275	15.29	No	No	0	1	1
261	R:R:E287	R:R:Y291	6.73	No	Yes	1	5	6
262	R:R:H293	R:R:N297	14.03	Yes	Yes	1	9	9
263	R:R:N297	R:R:Y301	8.14	Yes	Yes	1	9	9
264	R:R:F303	R:R:V299	3.93	No	No	0	7	6
265	R:R:I300	R:R:Y301	12.09	No	Yes	0	8	9
266	R:R:A302	R:R:F308	8.32	No	No	0	7	8
267	R:R:F303	R:R:F308	5.36	No	No	0	7	8
268	R:R:E306	R:R:R309	4.65	No	No	0	5	8
269	R:R:R318	R:R:Y311	10.29	Yes	No	6	5	4
270	R:R:F316	R:R:L312	7.31	No	No	0	6	5
271	R:R:Q314	R:R:R318	7.01	No	Yes	0	4	5
272	R:R:L315	R:R:R318	4.86	No	Yes	6	5	5
273	L:L:P75	L:L:V61	3.53	Yes	No	0	0	0
274	R:R:G207	R:R:I121	3.53	No	No	0	6	8
275	R:R:I78	R:R:W158	3.52	No	Yes	0	6	9
276	R:R:L127	R:R:Y301	3.52	No	Yes	0	9	9
277	R:R:F269	R:R:Q275	3.51	Yes	No	0	1	1
278	L:L:S35	R:R:A21	3.42	No	No	0	0	2
279	L:L:I41	L:L:P42	3.39	No	No	0	0	0
280	R:R:A302	R:R:V55	3.39	No	No	0	7	9
281	R:R:I289	R:R:P254	3.39	No	No	0	8	9
282	L:L:C32	L:L:T52	3.38	No	No	0	0	0
283	R:R:C218	R:R:T128	3.38	No	No	0	8	9
284	L:L:K88	L:L:P89	3.35	No	No	0	0	0
285	R:R:K94	R:R:P38	3.35	No	No	0	4	5
286	R:R:L210	R:R:P211	3.28	No	Yes	0	6	9
287	R:R:A134	R:R:I135	3.25	No	No	0	8	9
288	R:R:F122	R:R:F206	3.22	No	No	0	5	5
289	R:R:S184	R:R:T182	3.2	No	No	0	4	3
290	R:R:T128	R:R:V214	3.17	No	No	0	9	7
291	R:R:A302	R:R:L73	3.15	No	No	0	7	8
292	R:R:A21	R:R:D20	3.09	No	No	0	2	3
293	R:R:I71	R:R:V147	3.07	No	No	0	6	1
294	R:R:I129	R:R:V214	3.07	No	No	0	7	7
295	L:L:K58	L:L:S57	3.06	No	Yes	0	0	0
296	L:L:K74	L:L:S76	3.06	No	No	0	0	0
297	L:L:M84	L:L:V61	3.04	No	No	0	0	0
298	R:R:I152	R:R:T148	3.04	No	No	0	3	3
299	R:R:K196	R:R:V263	3.04	No	No	0	4	5
300	R:R:F32	R:R:G33	3.01	No	No	0	6	1
301	R:R:L169	R:R:S165	3	No	No	0	4	7
302	R:R:L279	R:R:S262	3	Yes	No	0	4	3
303	R:R:L87	R:R:V44	2.98	Yes	No	0	7	7
304	R:R:L227	R:R:V238	2.98	No	No	0	4	7
305	R:R:L257	R:R:T253	2.95	No	Yes	0	6	6
306	L:L:S38	R:R:D20	2.94	No	No	0	0	3
307	R:R:I152	R:R:I156	2.94	No	No	0	3	3
308	R:R:I129	R:R:L133	2.85	No	No	0	7	5
309	R:R:I156	R:R:L160	2.85	No	No	0	3	4
310	R:R:I217	R:R:L213	2.85	No	No	0	4	3
311	R:R:L59	R:R:L74	2.77	No	No	0	7	6
312	R:R:L117	R:R:L203	2.77	No	No	0	7	4
313	R:R:A141	R:R:R145	2.77	No	Yes	0	5	7
314	R:R:L201	R:R:L205	2.77	No	No	0	4	5
315	R:R:L81	R:R:N52	2.75	No	No	0	7	9
316	R:R:L36	R:R:Q35	2.66	No	No	0	6	3
317	R:R:S165	R:R:Y114	2.54	No	No	0	7	4
318	R:R:F112	R:R:I108	2.51	No	No	0	5	5
319	R:R:K63	R:R:R64	2.48	No	No	0	6	5
320	R:R:K224	R:R:R228	2.48	No	No	0	4	4
321	R:R:K236	R:R:R239	2.48	No	No	0	7	5
322	R:R:F45	R:R:L87	2.44	No	Yes	0	5	7
323	R:R:F303	R:R:L54	2.44	No	No	0	7	6
324	R:R:L82	R:R:W158	2.28	No	Yes	0	6	9
325	R:R:F140	R:R:H137	2.26	No	No	0	5	6
326	L:L:G79	L:L:P78	2.03	No	No	0	0	0
327	R:R:G51	R:R:P298	2.03	No	No	0	7	9
328	R:R:G111	R:R:S110	1.86	No	No	0	5	5
329	R:R:G168	R:R:S110	1.86	No	No	0	5	5
330	R:R:G116	R:R:S119	1.86	No	Yes	0	8	7
331	L:L:G77	L:L:V80	1.84	No	No	0	0	0
332	R:R:G51	R:R:V50	1.84	No	No	0	7	3
333	R:R:G221	R:R:V136	1.84	No	Yes	0	4	8
334	R:R:G305	R:R:V304	1.84	No	No	0	8	7
335	L:L:G68	L:L:T65	1.82	No	No	0	0	0
336	R:R:G221	R:R:T220	1.82	No	No	0	4	3
337	L:L:P42	L:L:S44	1.78	No	No	0	0	0
338	R:R:G150	R:R:I71	1.76	No	No	0	7	6
339	R:R:G102	R:R:M105	1.75	No	No	0	7	6
340	R:R:G221	R:R:K224	1.74	No	No	0	4	4
341	R:R:C295	R:R:V44	1.71	No	No	0	8	7
342	R:R:G48	R:R:L84	1.71	No	No	0	8	6
343	R:R:A161	R:R:S119	1.71	No	Yes	0	8	7
344	L:L:A73	L:L:V80	1.7	No	No	0	0	0
345	R:R:A77	R:R:V55	1.7	No	No	0	8	9
346	R:R:A77	R:R:V56	1.7	No	No	0	8	7
347	R:R:A200	R:R:V263	1.7	No	No	0	5	5
348	L:L:D82	L:L:G79	1.68	No	No	0	0	0
349	R:R:M166	R:R:P167	1.68	No	No	0	4	7
350	R:R:K202	R:R:P167	1.67	No	No	0	3	7
351	R:R:E306	R:R:G305	1.64	No	No	0	5	8
352	R:R:C24	R:R:K26	1.62	No	Yes	7	9	3
353	R:R:C273	R:R:K26	1.62	No	Yes	7	8	3
354	R:R:V147	R:R:V151	1.6	No	No	0	1	4
355	R:R:T286	R:R:V285	1.59	No	No	0	7	6
356	R:R:A237	R:R:L226	1.58	No	No	0	7	7
357	R:R:T146	R:R:T148	1.57	No	No	0	7	3
358	R:R:I91	R:R:S42	1.55	No	No	0	7	5
359	R:R:I47	R:R:V46	1.54	No	No	0	6	6
360	R:R:I247	R:R:V243	1.54	No	No	0	6	6
361	R:R:K66	R:R:S70	1.53	No	No	0	6	8
362	R:R:I216	R:R:T220	1.52	No	No	0	4	3
363	L:L:R69	R:R:G19	1.5	Yes	No	0	0	3
364	R:R:L40	R:R:V288	1.49	No	No	0	5	5
365	R:R:P230	R:R:R229	1.44	No	No	0	3	5
366	R:R:I157	R:R:L160	1.43	Yes	No	0	7	4
367	R:R:I244	R:R:L240	1.43	No	No	0	8	8
368	R:R:I246	R:R:L250	1.43	No	No	0	5	6
369	R:R:I261	R:R:L279	1.43	No	Yes	0	5	4
370	R:R:K236	R:R:L240	1.41	No	No	0	7	8
371	R:R:H180	R:R:T179	1.37	No	No	0	1	5
372	R:R:K310	R:R:Q314	1.36	No	No	0	5	4
373	R:R:E306	R:R:K233	1.35	No	No	0	5	4
374	R:R:F264	R:R:L268	1.22	No	No	0	4	1
375	R:R:F269	R:R:L268	1.22	Yes	No	0	1	1
376	R:R:L65	R:R:R64	1.21	No	No	0	7	5
377	R:R:F316	R:R:H317	1.13	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H27	8.3575	4	0	0
2	L:L:F28	10.725	4	0	0
3	L:L:S57	5	4	9	0
4	L:L:F63	5.1925	4	0	0
5	L:L:R69	4.26	4	5	0
6	L:L:P75	6.0275	4	0	0
7	R:R:Y18	7.825	4	5	7
8	R:R:K26	3.705	4	7	3
9	R:R:Y41	6.8475	4	0	7
10	R:R:Y62	8.5425	4	0	4
11	R:R:Y72	9.178	5	2	7
12	R:R:D80	7.742	5	1	9
13	R:R:L87	6.9225	4	0	7
14	R:R:W99	11.885	4	10	8
15	R:R:F101	9.06	4	0	7
16	R:R:Y113	6.40333	6	1	6
17	R:R:Y118	5.5875	4	0	7
18	R:R:S119	4.0675	4	3	7
19	R:R:E120	5.735	6	1	9
20	R:R:F123	10.135	4	3	7
21	R:R:I124	5.2725	4	1	8
22	R:R:D130	8.7275	4	2	8
23	R:R:V136	6.1525	4	11	8
24	R:R:R145	5.86333	6	2	7
25	R:R:I157	5.5525	4	0	7
26	R:R:W158	5.37333	6	3	9
27	R:R:Q175	8.8325	4	4	2
28	R:R:H186	10.645	4	4	4
29	R:R:F187	5.67833	6	8	5
30	R:R:P211	5.035	4	0	9
31	R:R:Y219	6.84333	6	0	9
32	R:R:F248	6.492	5	1	9
33	R:R:F251	4.3425	4	0	8
34	R:R:W252	9.345	4	1	9
35	R:R:T253	5.75	4	0	6
36	R:R:Y255	7.512	5	1	6
37	R:R:F269	4.76	4	0	1
38	R:R:L279	3.9325	4	0	4
39	R:R:Y291	10.7625	4	1	6
40	R:R:H293	9.234	5	1	9
41	R:R:C294	6.41	4	1	9
42	R:R:N297	7.682	5	1	9
43	R:R:Y301	7.266	5	1	9
44	R:R:R318	7.8775	4	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H27	R:R:D280	25.6712	7.56	Yes	No	0	0	3
2	L:L:H27	R:R:Q284	35.3812	6.18	Yes	No	0	0	3
3	R:R:L37	R:R:Q284	37.3122	7.99	No	No	0	5	3
4	R:R:L37	R:R:Y41	39.2396	8.21	No	Yes	0	5	7
5	R:R:L87	R:R:Y41	48.8218	10.55	Yes	Yes	0	7	7
6	R:R:L87	R:R:Y291	60.7841	11.72	Yes	Yes	0	7	6
7	R:R:Y113	R:R:Y291	20.088	3.97	Yes	Yes	1	6	6
8	R:R:T86	R:R:Y113	61.0433	3.75	No	Yes	0	6	6
9	R:R:T86	R:R:W90	60.5505	4.85	No	No	0	6	6
10	R:R:W90	R:R:Y93	60.0577	3.86	No	No	0	6	5
11	L:L:F28	R:R:Y93	46.7101	20.63	Yes	No	0	0	5
12	L:L:F28	R:R:R30	43.2386	6.41	Yes	No	0	0	2
13	L:L:D31	R:R:R30	42.0668	11.91	No	No	0	0	2
14	L:L:D31	R:R:Q25	41.4864	10.44	No	No	0	0	3
15	L:L:P75	R:R:H189	31.1267	10.68	Yes	No	0	0	4
16	L:L:E51	R:R:H189	31.583	8.62	No	No	0	0	4
17	L:L:E51	R:R:Q175	31.4114	5.1	No	Yes	4	0	2
18	L:L:F50	R:R:Q175	35.8667	18.74	No	Yes	0	0	2
19	L:L:F50	L:L:I62	38.1244	6.28	No	No	0	0	0
20	L:L:I62	L:L:Q70	38.6866	5.49	No	No	0	0	0
21	L:L:Q70	R:R:Q25	40.9097	5.12	No	No	0	0	3
22	R:R:D280	R:R:K26	21.7617	4.15	No	Yes	0	3	3
23	R:R:Y113	R:R:Y114	30.6339	13.9	Yes	No	0	6	4
24	R:R:Q199	R:R:Y114	24.3589	4.51	No	No	0	5	4
25	R:R:F187	R:R:Q199	23.6471	4.68	Yes	No	0	5	5
26	L:L:S54	R:R:F187	19.0184	6.61	No	Yes	0	0	5
27	L:L:S54	R:R:K196	18.4325	4.59	No	No	0	0	4
28	R:R:K196	R:R:V263	17.8685	3.04	No	No	0	4	5
29	R:R:F264	R:R:V263	16.7588	6.55	No	No	0	4	5
30	R:R:F264	R:R:L268	14.5102	1.22	No	No	0	4	1
31	R:R:F269	R:R:L268	13.9535	1.22	Yes	No	0	1	1
32	R:R:F269	R:R:L279	10.5587	7.31	Yes	Yes	0	1	4
33	L:L:P75	L:L:V61	26.1056	3.53	Yes	No	0	0	0
34	L:L:F63	L:L:V61	23.1798	7.87	Yes	No	0	0	0
35	L:L:F63	L:L:V71	15.556	3.93	Yes	No	0	0	0
36	R:R:W99	R:R:Y93	19.2374	10.61	Yes	No	0	8	5
37	R:R:K26	R:R:R277	13.8988	7.43	Yes	No	0	3	2
38	R:R:E29	R:R:R277	11.9239	8.14	No	No	0	4	2
39	R:R:F83	R:R:Y291	31.7016	20.63	No	Yes	1	6	6
40	R:R:C294	R:R:F83	56.6902	6.98	Yes	No	1	9	6
41	R:R:C294	R:R:D80	12.9187	9.34	Yes	Yes	1	9	9
42	R:R:C294	R:R:E120	49.6925	4.56	Yes	Yes	1	9	9
43	R:R:E120	R:R:W252	16.8793	6.54	Yes	Yes	1	9	9
44	R:R:F248	R:R:W252	86.6105	10.02	Yes	Yes	1	9	9
45	R:R:F248	R:R:L212	100	4.87	Yes	No	0	9	6
46	R:R:F249	R:R:L212	99.5656	3.65	No	No	0	6	6
47	R:R:F249	R:R:T253	98.2405	10.38	No	Yes	0	6	6
48	R:R:L208	R:R:T253	96.4226	4.42	No	Yes	0	8	6
49	R:R:L208	R:R:N256	95.959	10.98	No	No	0	8	8
50	R:R:L203	R:R:N256	94.5463	6.87	No	No	0	4	8
51	R:R:L203	R:R:Y118	93.5863	5.86	No	Yes	0	4	7
52	R:R:F122	R:R:Y118	90.6186	4.13	No	Yes	0	5	7
53	R:R:F122	R:R:I157	89.6001	5.02	No	Yes	0	5	7
54	R:R:I157	R:R:L126	80.3537	5.71	Yes	No	0	7	7
55	R:R:L126	R:R:Y72	79.777	17.58	No	Yes	0	7	7
56	R:R:M68	R:R:Y72	26.4524	11.97	No	Yes	2	7	7
57	R:R:M68	R:R:R145	25.7351	4.96	No	Yes	2	7	7
58	R:R:N67	R:R:R145	45.4288	6.03	No	Yes	2	7	7
59	R:R:N67	R:R:S70	65.7924	4.47	No	No	0	7	8
60	R:R:S70	R:R:Y62	61.1765	10.17	No	Yes	0	8	4
61	R:R:L59	R:R:Y62	35.5838	9.38	No	Yes	0	7	4
62	R:R:L59	R:R:L73	26.1056	6.92	No	No	0	7	8
63	R:R:A302	R:R:L73	23.742	3.15	No	No	0	7	8
64	R:R:A302	R:R:F308	19.0859	8.32	No	No	0	7	8
65	R:R:F303	R:R:F308	14.3277	5.36	No	No	0	7	8
66	R:R:Y113	R:R:Y255	61.2952	3.97	Yes	Yes	1	6	6
67	R:R:A290	R:R:Y255	73.2903	4	No	Yes	0	7	6
68	R:R:A290	R:R:W252	73.4144	3.89	No	Yes	0	7	9
69	R:R:E287	R:R:Y291	11.1774	6.73	No	Yes	1	5	6
70	R:R:E287	R:R:Y255	11.464	11.22	No	Yes	1	5	6
71	R:R:E120	R:R:H293	18.062	6.15	Yes	Yes	1	9	9
72	R:R:F248	R:R:H293	21.497	4.53	Yes	Yes	1	9	9
73	R:R:D130	R:R:Y72	49.7819	5.75	Yes	Yes	2	8	7
74	R:R:D130	R:R:R145	25.7369	10.72	Yes	Yes	2	8	7
75	R:R:D130	R:R:T69	23.3879	10.12	Yes	No	2	8	8
76	R:R:N67	R:R:T69	22.6615	5.85	No	No	2	7	8
77	R:R:Y311	R:R:Y62	16.6895	9.93	No	Yes	0	4	4
78	R:R:E120	R:R:I124	12.1046	4.1	Yes	Yes	1	9	8
79	R:R:D80	R:R:N297	13.1012	6.73	Yes	Yes	1	9	9
80	R:R:E120	R:R:N297	10.9548	5.26	Yes	Yes	1	9	9
81	R:R:F101	R:R:W99	10.723	16.04	Yes	Yes	0	7	8
82	R:R:N297	R:R:Y301	22.8677	8.14	Yes	Yes	1	9	9
83	R:R:I124	R:R:Y301	10.7868	8.46	Yes	Yes	1	8	9
84	R:R:R131	R:R:Y301	18.9874	4.12	No	Yes	0	9	9
85	R:R:R131	R:R:Y219	10.8872	7.2	No	Yes	0	9	9
86	R:R:T128	R:R:Y219	18.9874	3.75	No	Yes	0	9	9
87	R:R:F248	R:R:M215	27.9874	8.71	Yes	No	0	9	8
88	R:R:M215	R:R:Y219	27.2098	4.79	No	Yes	0	8	9
89	R:R:I244	R:R:R131	14.3386	3.76	No	No	0	8	9
90	R:R:I300	R:R:Y301	12.2817	12.09	No	Yes	0	8	9
91	R:R:I244	R:R:I300	10.9292	7.36	No	No	0	8	8
92	R:R:C218	R:R:T128	14.6142	3.38	No	No	0	8	9
93	R:R:C218	R:R:Y132	13.5118	8.06	No	No	0	8	8
94	R:R:I244	R:R:L240	22.7637	1.43	No	No	0	8	8
95	R:R:L240	R:R:V304	15.2001	5.96	No	No	0	8	7
96	R:R:G305	R:R:V304	12.6905	1.84	No	No	0	8	7
97	R:R:E306	R:R:G305	10.159	1.64	No	No	0	5	8
98	R:R:F83	R:R:Y113	24.3352	7.22	No	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H27	R:R:D280	7.56	0	Yes	No	0	3	0	1
L:L:H27	R:R:V283	11.07	0	Yes	No	0	4	0	1
L:L:H27	R:R:Q284	6.18	0	Yes	No	0	3	0	1
L:L:F28	R:R:R30	6.41	0	Yes	No	0	2	0	1
L:L:F28	R:R:Y93	20.63	0	Yes	No	0	5	0	1
L:L:F28	R:R:K94	8.69	0	Yes	No	0	4	0	1
L:L:F28	R:R:D97	7.17	0	Yes	No	0	3	0	1
L:L:A29	R:R:D280	4.63	0	No	No	0	3	0	1
L:L:D31	R:R:Q25	10.44	0	No	No	0	3	0	1
L:L:D31	R:R:R30	11.91	0	No	No	0	2	0	1
L:L:C33	R:R:P23	7.53	0	No	No	0	2	0	1
L:L:T34	R:R:C273	6.76	0	No	No	0	8	0	1
L:L:I37	R:R:D20	13.99	0	No	No	0	3	0	1
L:L:Q39	R:R:D17	7.83	0	No	No	0	8	0	1
L:L:S48	R:R:F178	3.96	0	No	No	0	1	0	1
L:L:F50	R:R:Q175	18.74	0	No	Yes	0	2	0	1
L:L:F50	R:R:E177	17.49	0	No	No	0	1	0	1
L:L:E51	R:R:Q175	5.1	4	No	Yes	0	2	0	1
L:L:E51	R:R:H186	9.85	4	No	Yes	0	4	0	1
L:L:E51	R:R:H189	8.62	4	No	No	0	4	0	1
L:L:S54	R:R:F187	6.61	0	No	Yes	0	5	0	1
L:L:S54	R:R:K196	4.59	0	No	No	0	4	0	1
L:L:S57	R:R:R193	5.27	9	Yes	No	0	1	0	1
L:L:S57	R:R:Q265	5.78	9	Yes	No	0	2	0	1
L:L:S57	R:R:D266	5.89	9	Yes	No	0	3	0	1
L:L:P59	R:R:L192	6.57	0	No	No	0	2	0	1
L:L:L64	R:R:F178	9.74	0	No	No	0	1	0	1
L:L:T65	R:R:Y18	9.99	5	No	Yes	0	7	0	1
L:L:K67	R:R:Y18	8.36	5	No	Yes	0	7	0	1
L:L:R69	R:R:Y18	4.12	5	Yes	Yes	0	7	0	1
L:L:R69	R:R:T22	6.47	5	Yes	No	0	5	0	1
L:L:Q70	R:R:P23	4.74	0	No	No	0	2	0	1
L:L:Q70	R:R:Q25	5.12	0	No	No	0	3	0	1
L:L:V71	R:R:Y18	8.83	0	No	Yes	0	7	0	1
L:L:P75	R:R:H189	10.68	0	Yes	No	0	4	0	1
L:L:S76	R:R:E190	4.31	0	No	No	0	4	0	1
R:R:C24	R:R:C273	7.28	7	No	No	9	8	2	1
R:R:D280	R:R:K26	4.15	0	No	Yes	3	3	1	2
R:R:R30	R:R:V27	3.92	0	No	No	2	1	1	2
R:R:L37	R:R:Q284	7.99	0	No	No	5	3	2	1
R:R:W90	R:R:Y93	3.86	0	No	No	6	5	2	1
R:R:W99	R:R:Y93	10.61	10	Yes	No	8	5	2	1
R:R:F171	R:R:F187	8.57	8	No	Yes	5	5	2	1
R:R:F171	R:R:P188	7.22	8	No	No	5	4	2	2
R:R:K173	R:R:Q175	4.07	4	No	Yes	4	2	2	1
R:R:H186	R:R:K173	18.34	4	Yes	No	4	4	1	2
R:R:H186	R:R:Q175	7.42	4	Yes	Yes	4	2	1	1
R:R:F178	R:R:W176	4.01	0	No	No	1	2	1	2
R:R:E177	R:R:H180	8.62	0	No	No	1	1	1	2
R:R:H186	R:R:S184	6.97	4	Yes	No	4	4	1	2
R:R:F187	R:R:L185	4.87	8	Yes	No	5	4	1	2
R:R:F187	R:R:P188	4.33	8	Yes	No	5	4	1	2
R:R:F187	R:R:W195	5.01	8	Yes	No	5	1	1	2
R:R:F187	R:R:Q199	4.68	8	Yes	No	5	5	1	2
R:R:E190	R:R:H189	4.92	0	No	No	4	4	1	1
R:R:D266	R:R:R193	9.53	9	No	No	3	1	1	1
R:R:F267	R:R:R193	6.41	0	No	No	1	1	2	1
R:R:Q265	R:R:S276	4.33	0	No	No	2	3	1	2
R:R:L279	R:R:Q265	3.99	0	Yes	No	4	2	2	1
L:L:S35	R:R:A21	3.42	0	No	No	0	2	0	1
R:R:K94	R:R:P38	3.35	0	No	No	4	5	1	2
R:R:A21	R:R:D20	3.09	0	No	No	2	3	1	1
R:R:K196	R:R:V263	3.04	0	No	No	4	5	1	2
L:L:S38	R:R:D20	2.94	0	No	No	0	3	0	1
R:R:C24	R:R:K26	1.62	7	No	Yes	9	3	2	2
R:R:C273	R:R:K26	1.62	7	No	Yes	8	3	1	2
L:L:R69	R:R:G19	1.5	5	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VLA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	345
Number of Links	377
Number of Hubs	44
Number of Links mediated by Hubs	165
Number of Communities	11
Number of Nodes involved in Communities	53
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	113836
Length Of Smallest Path	3
Average Path Length	21.3956
Length of Longest Path	52
Minimum Path Strength	1.22
Average Path Strength	6.91934
Maximum Path Strength	16.175
Minimum Path Correlation	0.7
Average Path Correlation	0.94122
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.27273
Average % Of Corr. Nodes	45.5559
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9127
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular function activator activity • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • chemoattractant activity • CCR chemokine receptor binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • chemotaxis • taxis • response to external stimulus • locomotion • cell chemotaxis • cell migration • cell motility • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response • immune response • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • immune system process • response to external biotic stimulus • positive regulation of locomotion • regulation of cell motility • positive regulation of biological process • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • inflammatory response • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • phospholipase activity • lipase activity • C-C chemokine binding • chemokine binding • chemokine (C-C motif) ligand 7 binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine (C-C motif) ligand 5 binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • calcium-mediated signaling • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • mononuclear cell migration • leukocyte chemotaxis • monocyte chemotaxis • myeloid leukocyte migration • positive regulation of monocyte chemotaxis • regulation of response to external stimulus • positive regulation of chemotaxis • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • response to wounding • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • cell adhesion • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of cellular process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of macromolecule metabolic process • secretion by cell • exocytosis • secretion • export from cell • vesicle-mediated transport • regulation of developmental process • negative regulation of biomineral tissue development • regulation of biomineral tissue development • regulation of bone mineralization • negative regulation of bone mineralization • ossification • biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • negative regulation of developmental process • bone mineralization • tissue development • negative regulation of ossification • negative regulation of multicellular organismal process • regulation of ossification • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • cell development • regulation of cell differentiation • positive regulation of osteoclast differentiation • regulation of cell development • positive regulation of developmental process • regulation of osteoclast differentiation • positive regulation of cell differentiation • positive regulation of hemopoiesis • cell differentiation • osteoclast differentiation • hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell development • regulation of myeloid leukocyte differentiation • positive regulation of myeloid leukocyte differentiation • myeloid cell differentiation • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of multicellular organismal process • positive regulation of leukocyte differentiation • leukocyte differentiation • cell surface • external side of plasma membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32246
Sequence	>7VLA_nogp_Chain_R D Y G D A T P C Q K V N E R A F G A Q L L P P L Y S L V F V I G L V G N I L V V L V L V Q Y K R L K N M T S I Y L L N L A I S D L L F L F T L P F W I D Y K L K D D W V F G D A M C K I L S G F Y Y T G L Y S E I F F I I L L T I D R Y L A I V H A V F A L R A R T V T F G V I T S I I I W A L A I L A S M P G L Y F S K T Q W E F T H H T C S L H F P H E S L R E W K L F Q A L K L N L F G L V L P L L V M I I C Y T G I I K I L L R R P N E K K S K A V R L I F V I M I I F F L F W T P Y N L T I L I S V F Q D F L F T H E C E Q S R H L D L A V Q V T E V I A Y T H C C V N P V I Y A F V G E R F R K Y L R Q L F H R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VL8	A	Protein	Chemokine	CCR1	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL8 (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	-	-		2.9	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL9	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(26-92)	-	Gi1/β1/γ2	2.6	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VL9 (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(26-92)	-		2.6	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VLA	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(27-92)	-	Gi1/β1/γ2	2.7	2022-03-23	doi.org/10.1038/s41589-021-00918-z
	7VLA (No Gprot)	A	Protein	Chemokine	CCR1	Homo sapiens	CCL15(27-92)	-		2.7	2022-03-23	doi.org/10.1038/s41589-021-00918-z

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