Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:H48 8.3575406
2L:L:F49 10.725403
3L:L:S78 5496
4L:L:F84 5.1925408
5L:L:R90 4.26455
6L:L:P96 6.0275409
7R:R:Y18 7.825457
8R:R:K26 3.705473
9R:R:Y41 6.8475407
10R:R:Y62 8.5425404
11R:R:Y72 9.178527
12R:R:D80 7.742519
13R:R:L87 6.9225407
14R:R:W99 11.8854108
15R:R:F101 9.06407
16R:R:Y113 6.40333616
17R:R:Y118 5.5875407
18R:R:S119 4.0675437
19R:R:E120 5.735619
20R:R:F123 10.135437
21R:R:I124 5.2725418
22R:R:D130 8.7275428
23R:R:V136 6.15254118
24R:R:R145 5.86333627
25R:R:I157 5.5525407
26R:R:W158 5.37333639
27R:R:Q175 8.8325442
28R:R:H186 10.645444
29R:R:F187 5.67833685
30R:R:P211 5.035409
31R:R:Y219 6.84333609
32R:R:F248 6.492519
33R:R:F251 4.3425408
34R:R:W252 9.345419
35R:R:T253 5.75406
36R:R:Y255 7.512516
37R:R:F269 4.76401
38R:R:L279 3.9325404
39R:R:Y291 10.7625416
40R:R:H293 9.234519
41R:R:C294 6.41419
42R:R:N297 7.682519
43R:R:Y301 7.266519
44R:R:R318 7.8775465
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H48 R:R:D280 25.67127.56YesNo063
2L:L:H48 R:R:Q284 35.38126.18YesNo063
3R:R:L37 R:R:Q284 37.31227.99NoNo053
4R:R:L37 R:R:Y41 39.23968.21NoYes057
5R:R:L87 R:R:Y41 48.821810.55YesYes077
6R:R:L87 R:R:Y291 60.784111.72YesYes076
7R:R:Y113 R:R:Y291 20.0883.97YesYes166
8R:R:T86 R:R:Y113 61.04333.75NoYes066
9R:R:T86 R:R:W90 60.55054.85NoNo066
10R:R:W90 R:R:Y93 60.05773.86NoNo065
11L:L:F49 R:R:Y93 46.710120.63YesNo035
12L:L:F49 R:R:R30 43.23866.41YesNo032
13L:L:D52 R:R:R30 42.066811.91NoNo052
14L:L:D52 R:R:Q25 41.486410.44NoNo053
15L:L:P96 R:R:H189 31.126710.68YesNo094
16L:L:E72 R:R:H189 31.5838.62NoNo044
17L:L:E72 R:R:Q175 31.41145.1NoYes442
18L:L:F71 R:R:Q175 35.866718.74NoYes052
19L:L:F71 L:L:I83 38.12446.28NoNo059
20L:L:I83 L:L:Q91 38.68665.49NoNo094
21L:L:Q91 R:R:Q25 40.90975.12NoNo043
22R:R:D280 R:R:K26 21.76174.15NoYes033
23R:R:Y113 R:R:Y114 30.633913.9YesNo064
24R:R:Q199 R:R:Y114 24.35894.51NoNo054
25R:R:F187 R:R:Q199 23.64714.68YesNo055
26L:L:S75 R:R:F187 19.01846.61NoYes075
27L:L:S75 R:R:K196 18.43254.59NoNo074
28R:R:K196 R:R:V263 17.86853.04NoNo045
29R:R:F264 R:R:V263 16.75886.55NoNo045
30R:R:F264 R:R:L268 14.51021.22NoNo041
31R:R:F269 R:R:L268 13.95351.22YesNo011
32R:R:F269 R:R:L279 10.55877.31YesYes014
33L:L:P96 L:L:V82 26.10563.53YesNo099
34L:L:F84 L:L:V82 23.17987.87YesNo089
35L:L:F84 L:L:V92 15.5563.93YesNo087
36R:R:W99 R:R:Y93 19.237410.61YesNo085
37R:R:K26 R:R:R277 13.89887.43YesNo032
38R:R:E29 R:R:R277 11.92398.14NoNo042
39R:R:F83 R:R:Y291 31.701620.63NoYes166
40R:R:C294 R:R:F83 56.69026.98YesNo196
41R:R:C294 R:R:D80 12.91879.34YesYes199
42R:R:C294 R:R:E120 49.69254.56YesYes199
43R:R:E120 R:R:W252 16.87936.54YesYes199
44R:R:F248 R:R:W252 86.610510.02YesYes199
45R:R:F248 R:R:L212 1004.87YesNo096
46R:R:F249 R:R:L212 99.56563.65NoNo066
47R:R:F249 R:R:T253 98.240510.38NoYes066
48R:R:L208 R:R:T253 96.42264.42NoYes086
49R:R:L208 R:R:N256 95.95910.98NoNo088
50R:R:L203 R:R:N256 94.54636.87NoNo048
51R:R:L203 R:R:Y118 93.58635.86NoYes047
52R:R:F122 R:R:Y118 90.61864.13NoYes057
53R:R:F122 R:R:I157 89.60015.02NoYes057
54R:R:I157 R:R:L126 80.35375.71YesNo077
55R:R:L126 R:R:Y72 79.77717.58NoYes077
56R:R:M68 R:R:Y72 26.452411.97NoYes277
57R:R:M68 R:R:R145 25.73514.96NoYes277
58R:R:N67 R:R:R145 45.42886.03NoYes277
59R:R:N67 R:R:S70 65.79244.47NoNo078
60R:R:S70 R:R:Y62 61.176510.17NoYes084
61R:R:L59 R:R:Y62 35.58389.38NoYes074
62R:R:L59 R:R:L73 26.10566.92NoNo078
63R:R:A302 R:R:L73 23.7423.15NoNo078
64R:R:A302 R:R:F308 19.08598.32NoNo078
65R:R:F303 R:R:F308 14.32775.36NoNo078
66R:R:Y113 R:R:Y255 61.29523.97YesYes166
67R:R:A290 R:R:Y255 73.29034NoYes076
68R:R:A290 R:R:W252 73.41443.89NoYes079
69R:R:E287 R:R:Y291 11.17746.73NoYes156
70R:R:E287 R:R:Y255 11.46411.22NoYes156
71R:R:E120 R:R:H293 18.0626.15YesYes199
72R:R:F248 R:R:H293 21.4974.53YesYes199
73R:R:D130 R:R:Y72 49.78195.75YesYes287
74R:R:D130 R:R:R145 25.736910.72YesYes287
75R:R:D130 R:R:T69 23.387910.12YesNo288
76R:R:N67 R:R:T69 22.66155.85NoNo278
77R:R:Y311 R:R:Y62 16.68959.93NoYes044
78R:R:E120 R:R:I124 12.10464.1YesYes198
79R:R:D80 R:R:N297 13.10126.73YesYes199
80R:R:E120 R:R:N297 10.95485.26YesYes199
81R:R:F101 R:R:W99 10.72316.04YesYes078
82R:R:N297 R:R:Y301 22.86778.14YesYes199
83R:R:I124 R:R:Y301 10.78688.46YesYes189
84R:R:R131 R:R:Y301 18.98744.12NoYes099
85R:R:R131 R:R:Y219 10.88727.2NoYes099
86R:R:T128 R:R:Y219 18.98743.75NoYes099
87R:R:F248 R:R:M215 27.98748.71YesNo098
88R:R:M215 R:R:Y219 27.20984.79NoYes089
89R:R:I244 R:R:R131 14.33863.76NoNo089
90R:R:I300 R:R:Y301 12.281712.09NoYes089
91R:R:I244 R:R:I300 10.92927.36NoNo088
92R:R:C218 R:R:T128 14.61423.38NoNo089
93R:R:C218 R:R:Y132 13.51188.06NoNo088
94R:R:I244 R:R:L240 22.76371.43NoNo088
95R:R:L240 R:R:V304 15.20015.96NoNo087
96R:R:G305 R:R:V304 12.69051.84NoNo087
97R:R:E306 R:R:G305 10.1591.64NoNo058
98R:R:F83 R:R:Y113 24.33527.22NoYes166
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H48 R:R:D280 7.56 0 Yes No 6 3 0 1
L:L:H48 R:R:V283 11.07 0 Yes No 6 4 0 1
L:L:H48 R:R:Q284 6.18 0 Yes No 6 3 0 1
L:L:F49 R:R:R30 6.41 0 Yes No 3 2 0 1
L:L:F49 R:R:Y93 20.63 0 Yes No 3 5 0 1
L:L:F49 R:R:K94 8.69 0 Yes No 3 4 0 1
L:L:F49 R:R:D97 7.17 0 Yes No 3 3 0 1
L:L:A50 R:R:D280 4.63 0 No No 6 3 0 1
L:L:D52 R:R:Q25 10.44 0 No No 5 3 0 1
L:L:D52 R:R:R30 11.91 0 No No 5 2 0 1
L:L:C54 R:R:P23 7.53 0 No No 9 2 0 1
L:L:T55 R:R:C273 6.76 0 No No 5 8 0 1
L:L:I58 R:R:D20 13.99 0 No No 5 3 0 1
L:L:Q60 R:R:D17 7.83 0 No No 6 8 0 1
L:L:S69 R:R:F178 3.96 0 No No 7 1 0 1
L:L:F71 R:R:Q175 18.74 0 No Yes 5 2 0 1
L:L:F71 R:R:E177 17.49 0 No No 5 1 0 1
L:L:E72 R:R:Q175 5.1 4 No Yes 4 2 0 1
L:L:E72 R:R:H186 9.85 4 No Yes 4 4 0 1
L:L:E72 R:R:H189 8.62 4 No No 4 4 0 1
L:L:S75 R:R:F187 6.61 0 No Yes 7 5 0 1
L:L:S75 R:R:K196 4.59 0 No No 7 4 0 1
L:L:S78 R:R:R193 5.27 9 Yes No 6 1 0 1
L:L:S78 R:R:Q265 5.78 9 Yes No 6 2 0 1
L:L:S78 R:R:D266 5.89 9 Yes No 6 3 0 1
L:L:P80 R:R:L192 6.57 0 No No 8 2 0 1
L:L:L85 R:R:F178 9.74 0 No No 5 1 0 1
L:L:T86 R:R:Y18 9.99 5 No Yes 9 7 0 1
L:L:K88 R:R:Y18 8.36 5 No Yes 5 7 0 1
L:L:R90 R:R:Y18 4.12 5 Yes Yes 5 7 0 1
L:L:R90 R:R:T22 6.47 5 Yes No 5 5 0 1
L:L:Q91 R:R:P23 4.74 0 No No 4 2 0 1
L:L:Q91 R:R:Q25 5.12 0 No No 4 3 0 1
L:L:V92 R:R:Y18 8.83 0 No Yes 7 7 0 1
L:L:P96 R:R:H189 10.68 0 Yes No 9 4 0 1
L:L:S97 R:R:E190 4.31 0 No No 4 4 0 1
R:R:C24 R:R:C273 7.28 7 No No 9 8 2 1
R:R:D280 R:R:K26 4.15 0 No Yes 3 3 1 2
R:R:R30 R:R:V27 3.92 0 No No 2 1 1 2
R:R:L37 R:R:Q284 7.99 0 No No 5 3 2 1
R:R:W90 R:R:Y93 3.86 0 No No 6 5 2 1
R:R:W99 R:R:Y93 10.61 10 Yes No 8 5 2 1
R:R:F171 R:R:F187 8.57 8 No Yes 5 5 2 1
R:R:F171 R:R:P188 7.22 8 No No 5 4 2 2
R:R:K173 R:R:Q175 4.07 4 No Yes 4 2 2 1
R:R:H186 R:R:K173 18.34 4 Yes No 4 4 1 2
R:R:H186 R:R:Q175 7.42 4 Yes Yes 4 2 1 1
R:R:F178 R:R:W176 4.01 0 No No 1 2 1 2
R:R:E177 R:R:H180 8.62 0 No No 1 1 1 2
R:R:H186 R:R:S184 6.97 4 Yes No 4 4 1 2
R:R:F187 R:R:L185 4.87 8 Yes No 5 4 1 2
R:R:F187 R:R:P188 4.33 8 Yes No 5 4 1 2
R:R:F187 R:R:W195 5.01 8 Yes No 5 1 1 2
R:R:F187 R:R:Q199 4.68 8 Yes No 5 5 1 2
R:R:E190 R:R:H189 4.92 0 No No 4 4 1 1
R:R:D266 R:R:R193 9.53 9 No No 3 1 1 1
R:R:F267 R:R:R193 6.41 0 No No 1 1 2 1
R:R:Q265 R:R:S276 4.33 0 No No 2 3 1 2
R:R:L279 R:R:Q265 3.99 0 Yes No 4 2 2 1
L:L:S56 R:R:A21 3.42 0 No No 7 2 0 1
R:R:K94 R:R:P38 3.35 0 No No 4 5 1 2
R:R:A21 R:R:D20 3.09 0 No No 2 3 1 1
R:R:K196 R:R:V263 3.04 0 No No 4 5 1 2
L:L:S59 R:R:D20 2.94 0 No No 3 3 0 1
R:R:C24 R:R:K26 1.62 7 No Yes 9 3 2 2
R:R:C273 R:R:K26 1.62 7 No Yes 8 3 1 2
L:L:R90 R:R:G19 1.5 5 Yes No 5 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7VLA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.65
Number of Linked Nodes 345
Number of Links 377
Number of Hubs 44
Number of Links mediated by Hubs 165
Number of Communities 11
Number of Nodes involved in Communities 53
Number of Links involved in Communities 70
Path Summary
Number Of Nodes in MetaPath 99
Number Of Links MetaPath 98
Number of Shortest Paths 113836
Length Of Smallest Path 3
Average Path Length 21.3956
Length of Longest Path 52
Minimum Path Strength 1.22
Average Path Strength 6.91934
Maximum Path Strength 16.175
Minimum Path Correlation 0.7
Average Path Correlation 0.94122
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 45.5559
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.9127
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Interleukin 8-like chemokines   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Interleukin 8-like chemokines   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinCCL15(27-92)
UniProtQ16663
Sequence
>7VLA_nogp_Chain_L
HFAADCCTS YISQSIPCS LMKSYFETS SECSKPGVI FLTKKGRQV 
CAKPSGPGV QDCMKKLKP Y


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32246
Sequence
>7VLA_nogp_Chain_R
DYGDATPCQ KVNERAFGA QLLPPLYSL VFVIGLVGN ILVVLVLVQ 
YKRLKNMTS IYLLNLAIS DLLFLFTLP FWIDYKLKD DWVFGDAMC 
KILSGFYYT GLYSEIFFI ILLTIDRYL AIVHAVFAL RARTVTFGV 
ITSIIIWAL AILASMPGL YFSKTQWEF THHTCSLHF PHESLREWK 
LFQALKLNL FGLVLPLLV MIICYTGII KILLRRPNE KKSKAVRLI 
FVIMIIFFL FWTPYNLTI LISVFQDFL FTHECEQSR HLDLAVQVT 
EVIAYTHCC VNPVIYAFV GERFRKYLR QLFHR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VL8AProteinChemokineCCR1Homo sapiens--Gi1/β1/γ22.92022-03-23doi.org/10.1038/s41589-021-00918-z
7VL8 (No Gprot) AProteinChemokineCCR1Homo sapiens--2.92022-03-23doi.org/10.1038/s41589-021-00918-z
7VL9AProteinChemokineCCR1Homo sapiensCCL15(26-92)-Gi1/β1/γ22.62022-03-23doi.org/10.1038/s41589-021-00918-z
7VL9 (No Gprot) AProteinChemokineCCR1Homo sapiensCCL15(26-92)-2.62022-03-23doi.org/10.1038/s41589-021-00918-z
7VLAAProteinChemokineCCR1Homo sapiensCCL15(27-92)-Gi1/β1/γ22.72022-03-23doi.org/10.1038/s41589-021-00918-z
7VLA (No Gprot) AProteinChemokineCCR1Homo sapiensCCL15(27-92)-2.72022-03-23doi.org/10.1038/s41589-021-00918-z




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