psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L20	L:L:Y18	7.03	No	No	0	0	0
2	L:L:Y18	R:R:E299	6.73	No	No	0	0	1
3	L:L:F19	L:L:F21	12.86	No	Yes	1	0	0
4	L:L:F19	R:R:N109	9.67	No	No	0	0	2
5	L:L:F19	R:R:N306	4.83	No	No	1	0	4
6	L:L:L20	R:R:W297	11.39	No	No	0	0	1
7	L:L:F21	R:R:M106	3.73	Yes	Yes	1	0	5
8	L:L:F21	R:R:N306	9.67	Yes	No	1	0	4
9	L:L:F21	R:R:H309	19.23	Yes	No	1	0	4
10	L:L:R22	R:R:E105	10.47	Yes	No	0	0	4
11	L:L:R22	R:R:N109	4.82	Yes	No	0	0	2
12	L:L:R22	R:R:T203	5.17	Yes	No	3	0	4
13	L:L:R22	R:R:T205	5.17	Yes	No	3	0	4
14	L:L:P23	R:R:Y213	5.56	No	Yes	0	0	2
15	L:L:P23	R:R:F291	21.67	No	No	0	0	4
16	L:L:R24	R:R:E102	11.63	Yes	Yes	1	0	6
17	L:L:R24	R:R:D287	7.15	Yes	No	1	0	5
18	L:L:R24	R:R:H309	21.44	Yes	No	1	0	4
19	L:L:R24	R:R:S312	5.27	Yes	No	1	0	7
20	L:L:R24	R:R:G313	6	Yes	No	0	0	5
21	L:L:N25	R:R:N181	16.35	Yes	Yes	1	0	4
22	L:L:N25	R:R:H185	15.31	Yes	No	0	0	5
23	L:L:N25	R:R:Y213	11.63	Yes	Yes	1	0	2
24	L:L:N25	R:R:R288	6.03	Yes	Yes	1	0	5
25	R:R:F44	R:R:H43	9.05	No	No	0	1	5
26	R:R:F44	R:R:V48	5.24	No	Yes	1	1	6
27	R:R:F44	R:R:V310	7.87	No	No	1	1	4
28	R:R:V48	R:R:Y52	8.83	Yes	Yes	1	6	7
29	R:R:M106	R:R:V48	6.09	Yes	Yes	1	5	6
30	R:R:V310	R:R:V48	8.02	No	Yes	1	4	6
31	R:R:M99	R:R:Y52	7.18	Yes	Yes	1	7	7
32	R:R:E102	R:R:Y52	8.98	Yes	Yes	1	6	7
33	R:R:M106	R:R:Y52	3.59	Yes	Yes	1	5	7
34	R:R:Y317	R:R:Y52	6.95	Yes	Yes	1	7	7
35	R:R:P54	R:R:V53	3.53	No	No	0	4	5
36	R:R:I55	R:R:L318	4.28	No	No	0	7	5
37	R:R:F56	R:R:V60	7.87	Yes	No	0	6	6
38	R:R:F56	R:R:L95	3.65	Yes	No	0	6	7
39	R:R:F56	R:R:L96	4.87	Yes	No	0	6	5
40	R:R:F56	R:R:M99	11.2	Yes	Yes	0	6	7
41	R:R:G59	R:R:V58	3.68	No	No	0	8	5
42	R:R:L92	R:R:V60	4.47	No	No	0	7	6
43	R:R:G62	R:R:I61	3.53	No	No	0	8	5
44	R:R:G62	R:R:P324	4.06	No	No	0	8	9
45	R:R:A88	R:R:N63	4.69	No	Yes	0	9	9
46	R:R:D91	R:R:N63	6.73	Yes	Yes	0	9	9
47	R:R:L92	R:R:N63	5.49	No	Yes	0	7	9
48	R:R:N63	R:R:P324	13.03	Yes	No	0	9	9
49	R:R:N328	R:R:V66	16.26	No	No	2	7	9
50	R:R:F334	R:R:V66	3.93	Yes	No	2	8	9
51	R:R:F334	R:R:V69	11.8	Yes	No	0	8	8
52	R:R:I70	R:R:M76	4.37	Yes	Yes	2	7	7
53	R:R:I70	R:R:N81	7.08	Yes	Yes	2	7	8
54	R:R:F85	R:R:I70	5.02	No	Yes	0	5	7
55	R:R:Q72	R:R:V341	8.6	No	No	2	4	6
56	R:R:F345	R:R:Q72	9.37	No	No	2	1	4
57	R:R:H73	R:R:M76	5.25	Yes	Yes	2	5	7
58	R:R:A337	R:R:H73	4.39	No	Yes	2	5	5
59	R:R:H73	R:R:N340	7.65	Yes	No	0	5	5
60	R:R:M76	R:R:N81	12.62	Yes	Yes	2	7	8
61	R:R:M76	R:R:R333	11.17	Yes	No	2	7	6
62	R:R:F334	R:R:M76	4.98	Yes	Yes	2	8	7
63	R:R:A337	R:R:M76	4.83	No	Yes	2	5	7
64	R:R:K77	R:R:Y82	7.17	No	Yes	4	7	5
65	R:R:K77	R:R:R160	6.19	No	No	4	7	2
66	R:R:P79	R:R:T78	5.25	No	No	0	6	8
67	R:R:N81	R:R:T78	5.85	Yes	No	2	8	8
68	R:R:R333	R:R:T78	7.76	No	No	2	6	8
69	R:R:P79	R:R:S158	7.13	No	No	0	6	6
70	R:R:N81	R:R:R333	6.03	Yes	No	2	8	6
71	R:R:R160	R:R:Y82	10.29	No	Yes	4	2	5
72	R:R:A163	R:R:Y82	4	No	Yes	0	7	5
73	R:R:L164	R:R:Y82	5.86	No	Yes	0	3	5
74	R:R:T139	R:R:Y83	6.24	No	Yes	0	8	7
75	R:R:E143	R:R:Y83	13.47	No	Yes	0	8	7
76	R:R:A163	R:R:Y83	4	No	Yes	0	7	7
77	R:R:I166	R:R:Y83	8.46	No	Yes	0	5	7
78	R:R:L84	R:R:Y327	3.52	No	Yes	0	8	9
79	R:R:L84	R:R:N328	15.1	No	No	0	8	7
80	R:R:F85	R:R:V89	5.24	No	No	0	5	6
81	R:R:S136	R:R:S86	4.89	No	No	0	8	9
82	R:R:L167	R:R:S86	9.01	No	No	0	7	9
83	R:R:D91	R:R:L87	6.79	Yes	Yes	0	9	9
84	R:R:I137	R:R:L87	7.14	Yes	Yes	1	8	9
85	R:R:L87	R:R:Y327	3.52	Yes	Yes	1	9	9
86	R:R:S90	R:R:W171	3.71	No	No	0	8	9
87	R:R:D91	R:R:S133	5.89	Yes	No	0	9	9
88	R:R:D91	R:R:S320	8.83	Yes	No	0	9	8
89	R:R:D91	R:R:N323	10.77	Yes	No	0	9	9
90	R:R:L92	R:R:L96	6.92	No	No	0	7	5
91	R:R:L93	R:R:V129	5.96	No	No	0	7	8
92	R:R:V129	R:R:V94	4.81	No	No	0	8	7
93	R:R:F316	R:R:V94	3.93	Yes	No	0	8	7
94	R:R:S320	R:R:V94	4.85	No	No	0	8	7
95	R:R:L95	R:R:S320	4.5	No	No	0	7	8
96	R:R:G98	R:R:Y317	4.35	No	Yes	0	6	7
97	R:R:M99	R:R:Y317	7.18	Yes	Yes	1	7	7
98	R:R:F114	R:R:L101	4.87	Yes	No	0	7	5
99	R:R:K122	R:R:L101	5.64	No	No	0	5	5
100	R:R:E102	R:R:H309	3.69	Yes	No	1	6	4
101	R:R:E102	R:R:Y317	12.35	Yes	Yes	1	6	7
102	R:R:W107	R:R:Y104	3.86	No	No	5	4	4
103	R:R:R108	R:R:Y104	10.29	No	No	5	4	4
104	R:R:L113	R:R:Y104	12.89	No	No	0	3	4
105	R:R:E105	R:R:K122	4.05	No	No	0	4	5
106	R:R:R108	R:R:W107	15.99	No	No	5	4	4
107	R:R:P111	R:R:R108	10.09	No	No	0	4	4
108	R:R:S201	R:R:Y110	7.63	No	No	0	2	4
109	R:R:F112	R:R:F114	8.57	No	Yes	0	8	7
110	R:R:C119	R:R:F112	4.19	No	No	6	9	8
111	R:R:C204	R:R:F112	9.78	No	No	6	9	8
112	R:R:F114	R:R:L113	6.09	Yes	No	0	7	3
113	R:R:F114	R:R:G118	4.52	Yes	No	0	7	5
114	R:R:G115	R:R:P116	4.06	No	No	0	7	3
115	R:R:F121	R:R:V117	5.24	No	No	0	5	3
116	R:R:C119	R:R:C204	5.46	No	No	6	9	9
117	R:R:T182	R:R:Y120	4.99	No	No	0	5	6
118	R:R:T123	R:R:T182	7.85	No	No	0	5	5
119	R:R:H185	R:R:T123	10.95	No	No	0	5	5
120	R:R:A124	R:R:T182	5.03	No	No	0	7	5
121	R:R:C130	R:R:F126	5.59	No	No	0	7	6
122	R:R:F126	R:R:F316	5.36	No	Yes	0	6	8
123	R:R:E127	R:R:F131	8.16	Yes	No	0	4	6
124	R:R:E127	R:R:S178	4.31	Yes	No	0	4	7
125	R:R:E127	R:R:N181	11.83	Yes	Yes	1	4	4
126	R:R:E127	R:R:R288	10.47	Yes	Yes	1	4	5
127	R:R:T128	R:R:V175	7.93	No	No	0	5	4
128	R:R:C130	R:R:W281	5.22	No	Yes	0	7	8
129	R:R:F131	R:R:F224	19.29	No	Yes	0	6	5
130	R:R:A132	R:R:W171	7.78	No	No	0	7	9
131	R:R:F277	R:R:I134	3.77	Yes	No	1	9	8
132	R:R:I134	R:R:W281	11.74	No	Yes	1	8	8
133	R:R:L135	R:R:V170	5.96	No	No	0	5	7
134	R:R:F224	R:R:L135	3.65	Yes	No	0	5	5
135	R:R:F277	R:R:I137	3.77	Yes	Yes	1	9	8
136	R:R:I137	R:R:N323	4.25	Yes	No	0	8	9
137	R:R:I137	R:R:Y327	10.88	Yes	Yes	1	8	9
138	R:R:R144	R:R:V140	6.54	No	No	0	9	9
139	R:R:I232	R:R:S141	6.19	No	No	0	8	9
140	R:R:L235	R:R:S141	6.01	Yes	No	0	8	9
141	R:R:S141	R:R:Y236	8.9	No	Yes	0	9	9
142	R:R:E143	R:R:R162	9.3	No	Yes	0	8	4
143	R:R:R144	R:R:Y236	7.2	No	Yes	0	9	9
144	R:R:R144	R:R:Y327	6.17	No	Yes	0	9	9
145	R:R:L149	R:R:Y145	12.89	No	Yes	0	7	8
146	R:R:L235	R:R:Y145	16.41	Yes	Yes	0	8	8
147	R:R:L238	R:R:Y145	4.69	No	Yes	0	4	8
148	R:R:M239	R:R:Y145	3.59	Yes	Yes	0	9	8
149	R:R:R153	R:R:V146	9.15	No	No	0	4	5
150	R:R:I148	R:R:M239	7.29	No	Yes	0	8	9
151	R:R:L149	R:R:R242	17.01	No	No	0	7	5
152	R:R:Q157	R:R:R153	17.52	No	No	0	3	4
153	R:R:Q157	R:R:R162	4.67	No	Yes	0	3	4
154	R:R:I166	R:R:R162	8.77	No	Yes	0	5	4
155	R:R:F173	R:R:I169	3.77	No	No	0	4	4
156	R:R:F177	R:R:L176	3.65	Yes	No	0	4	4
157	R:R:F177	R:R:F224	10.72	Yes	Yes	7	4	5
158	R:R:N181	R:R:Y213	4.65	Yes	Yes	1	4	2
159	R:R:I216	R:R:N181	4.25	No	Yes	0	5	4
160	R:R:I217	R:R:N181	4.25	Yes	Yes	1	5	4
161	R:R:N181	R:R:R288	3.62	Yes	Yes	1	4	5
162	R:R:I184	R:R:K208	8.72	Yes	No	0	5	4
163	R:R:I184	R:R:I212	4.42	Yes	No	0	5	2
164	R:R:H185	R:R:V206	4.15	No	No	0	5	4
165	R:R:G186	R:R:I207	3.53	No	No	0	4	3
166	R:R:F189	R:R:I187	10.05	No	No	0	1	6
167	R:R:K188	R:R:T205	7.51	No	No	0	1	4
168	R:R:A202	R:R:F189	4.16	No	No	0	5	1
169	R:R:H190	R:R:S201	8.37	No	No	0	1	2
170	R:R:G195	R:R:S196	3.71	No	No	0	2	6
171	R:R:T203	R:R:T205	4.71	No	No	3	4	4
172	R:R:V206	R:R:Y213	12.62	No	Yes	0	4	2
173	R:R:P209	R:R:W211	8.11	No	No	8	6	1
174	R:R:I212	R:R:P209	5.08	No	No	8	2	6
175	R:R:I212	R:R:W211	12.92	No	No	8	2	1
176	R:R:I217	R:R:Y213	13.3	Yes	Yes	1	5	2
177	R:R:N214	R:R:Q218	11.88	No	No	9	3	4
178	R:R:N214	R:R:S292	8.94	No	No	0	3	4
179	R:R:F293	R:R:N214	12.08	No	No	9	4	3
180	R:R:F215	R:R:V219	5.24	No	No	0	3	3
181	R:R:I217	R:R:R288	3.76	Yes	Yes	1	5	5
182	R:R:I217	R:R:L289	4.28	Yes	No	0	5	6
183	R:R:I217	R:R:S292	6.19	Yes	No	0	5	4
184	R:R:F293	R:R:Q218	7.03	No	No	9	4	4
185	R:R:R288	R:R:T220	3.88	Yes	No	0	5	4
186	R:R:H285	R:R:S221	9.76	No	No	0	7	5
187	R:R:L289	R:R:S221	6.01	No	No	0	6	5
188	R:R:F222	R:R:L223	3.65	No	Yes	0	4	4
189	R:R:F222	R:R:L227	9.74	No	No	0	4	6
190	R:R:M229	R:R:Y225	3.59	No	No	0	7	8
191	R:R:A282	R:R:Y225	4	No	No	0	6	8
192	R:R:H285	R:R:Y225	8.71	No	No	0	7	8
193	R:R:F277	R:R:M229	3.73	Yes	No	0	9	7
194	R:R:A278	R:R:M229	4.83	No	No	0	6	7
195	R:R:F277	R:R:I232	7.54	Yes	No	0	9	8
196	R:R:M239	R:R:Y236	4.79	Yes	Yes	1	9	9
197	R:R:L270	R:R:Y236	11.72	Yes	Yes	1	8	9
198	R:R:L273	R:R:Y236	4.69	No	Yes	1	8	9
199	R:R:V274	R:R:Y236	5.05	No	Yes	0	8	9
200	R:R:L241	R:R:Y237	14.07	No	No	0	3	4
201	R:R:L270	R:R:M239	4.24	Yes	Yes	1	8	9
202	R:R:A240	R:R:N267	4.69	No	No	0	5	6
203	R:R:K244	R:R:R263	7.43	No	No	0	4	7
204	R:R:K245	R:R:L249	5.64	No	No	0	4	2
205	R:R:D246	R:R:K247	5.53	No	No	0	6	4
206	R:R:D246	R:R:N255	6.73	No	No	10	6	3
207	R:R:D246	R:R:Q259	6.53	No	No	10	6	3
208	R:R:A251	R:R:K247	6.42	No	No	0	2	4
209	R:R:N255	R:R:Q259	9.24	No	No	10	3	3
210	R:R:I258	R:R:N257	11.33	No	No	0	4	3
211	R:R:N267	R:R:R263	6.03	No	No	0	6	7
212	R:R:I326	R:R:L273	7.14	Yes	No	1	8	8
213	R:R:L273	R:R:Y327	11.72	No	Yes	1	8	9
214	R:R:I326	R:R:V276	4.61	Yes	No	0	8	7
215	R:R:F277	R:R:W281	5.01	Yes	Yes	1	9	8
216	R:R:C280	R:R:S319	6.89	No	No	0	8	9
217	R:R:F284	R:R:W281	5.01	Yes	Yes	1	6	8
218	R:R:F316	R:R:W281	8.02	Yes	Yes	1	8	8
219	R:R:S319	R:R:W281	4.94	No	Yes	0	9	8
220	R:R:P283	R:R:S312	3.56	No	No	0	9	7
221	R:R:F315	R:R:P283	5.78	No	No	0	7	9
222	R:R:F284	R:R:H285	9.05	Yes	No	0	6	7
223	R:R:F284	R:R:R288	16.03	Yes	Yes	1	6	5
224	R:R:F284	R:R:F316	9.65	Yes	Yes	1	6	8
225	R:R:D287	R:R:R288	5.96	No	Yes	1	5	5
226	R:R:D287	R:R:S312	8.83	No	No	1	5	7
227	R:R:F293	R:R:L289	6.09	No	No	0	4	6
228	R:R:F290	R:R:L301	4.87	Yes	No	0	4	1
229	R:R:F290	R:R:F305	17.15	Yes	No	0	4	5
230	R:R:F290	R:R:V308	5.24	Yes	No	0	4	4
231	R:R:F291	R:R:W297	17.04	No	No	0	4	1
232	R:R:F291	R:R:F305	9.65	No	No	0	4	5
233	R:R:V294	R:R:W297	9.81	No	No	0	3	1
234	R:R:L301	R:R:V294	5.96	No	No	0	1	3
235	R:R:F316	R:R:Y317	13.41	Yes	Yes	1	8	7
236	R:R:I326	R:R:Y327	6.04	Yes	Yes	1	8	9
237	R:R:F334	R:R:N328	6.04	Yes	No	2	8	7
238	R:R:F334	R:R:L329	4.87	Yes	No	0	8	6
239	R:R:Q335	R:R:R332	7.01	No	No	0	8	4
240	R:R:F338	R:R:I342	10.05	No	No	0	6	5
241	R:R:F345	R:R:V341	6.55	No	No	2	1	6
242	R:R:F345	R:R:S344	3.96	No	No	0	1	5
243	R:R:P228	R:R:T138	3.5	No	No	0	9	7
244	R:R:C67	R:R:V64	3.42	No	No	0	7	4
245	R:R:A132	R:R:S174	3.42	No	No	0	7	8
246	R:R:I187	R:R:P116	3.39	No	No	0	6	3
247	R:R:I134	R:R:P228	3.39	No	No	0	8	9
248	R:R:M99	R:R:P100	3.35	Yes	No	0	7	8
249	R:R:L46	R:R:P47	3.28	No	No	0	2	4
250	R:R:C119	R:R:I187	3.27	No	No	0	9	6
251	R:R:S133	R:R:S90	3.26	No	No	0	9	8
252	R:R:N194	R:R:P193	3.26	No	No	0	5	1
253	R:R:S233	R:R:V274	3.23	No	No	0	4	8
254	R:R:V314	R:R:V51	3.21	No	No	0	5	5
255	R:R:S174	R:R:T128	3.2	No	No	0	8	5
256	R:R:S178	R:R:T128	3.2	No	No	0	7	5
257	R:R:R260	R:R:R263	3.2	No	No	0	3	7
258	L:L:L20	R:R:A302	3.15	No	No	0	0	1
259	R:R:I184	R:R:S183	3.1	Yes	No	0	5	5
260	R:R:M210	R:R:V206	3.04	No	No	0	3	4
261	R:R:L87	R:R:S136	3	Yes	No	0	9	8
262	R:R:L68	R:R:V64	2.98	No	No	0	4	4
263	R:R:L235	R:R:V142	2.98	Yes	No	0	8	6
264	R:R:L223	R:R:V219	2.98	Yes	No	0	4	3
265	R:R:L235	R:R:V231	2.98	Yes	No	0	8	7
266	R:R:L238	R:R:V234	2.98	No	No	0	4	4
267	R:R:L243	R:R:V266	2.98	No	Yes	0	8	7
268	R:R:L270	R:R:V266	2.98	Yes	Yes	0	8	7
269	R:R:L318	R:R:V322	2.98	No	No	0	5	6
270	R:R:I184	R:R:I216	2.94	Yes	No	0	5	5
271	R:R:I325	R:R:I326	2.94	No	Yes	0	7	8
272	R:R:A75	R:R:H73	2.93	No	Yes	0	5	5
273	R:R:I55	R:R:M99	2.92	No	Yes	0	7	7
274	R:R:I207	R:R:K208	2.91	No	No	0	3	4
275	R:R:E250	R:R:S248	2.87	No	No	0	4	4
276	R:R:I325	R:R:L330	2.85	No	No	0	7	7
277	R:R:C67	R:R:F85	2.79	No	No	0	7	5
278	R:R:P111	R:R:Y110	2.78	No	No	0	4	4
279	R:R:H73	R:R:V341	2.77	Yes	No	2	5	6
280	R:R:A256	R:R:R260	2.77	No	No	0	2	3
281	R:R:F338	R:R:V69	2.62	No	No	0	6	8
282	R:R:F290	R:R:V304	2.62	Yes	No	0	4	4
283	R:R:F315	R:R:V314	2.62	No	No	0	7	5
284	R:R:H150	R:R:L149	2.57	No	No	0	6	7
285	R:R:V140	R:R:Y83	2.52	No	Yes	0	9	7
286	R:R:F315	R:R:I279	2.51	No	No	0	7	5
287	R:R:F45	R:R:M106	2.49	No	Yes	0	4	5
288	R:R:F338	R:R:L65	2.44	No	No	0	6	7
289	R:R:F177	R:R:L223	2.44	Yes	Yes	7	4	4
290	R:R:F222	R:R:L226	2.44	No	No	0	4	4
291	R:R:F224	R:R:L223	2.44	Yes	Yes	7	5	4
292	R:R:F192	R:R:N194	2.42	No	No	0	3	5
293	R:R:F173	R:R:F177	2.14	No	Yes	0	4	4
294	R:R:A321	R:R:G59	1.95	No	No	0	7	8
295	R:R:G118	R:R:V117	1.84	No	No	0	5	3
296	R:R:G172	R:R:V175	1.84	No	No	0	5	4
297	R:R:A147	R:R:A154	1.79	No	No	0	8	6
298	R:R:G59	R:R:L95	1.71	No	No	0	8	7
299	R:R:G168	R:R:L167	1.71	No	No	0	4	7
300	R:R:C262	R:R:V266	1.71	No	Yes	0	5	7
301	R:R:A154	R:R:V146	1.7	No	No	0	6	5
302	R:R:L179	R:R:P180	1.64	No	No	0	4	8
303	R:R:S298	R:R:S300	1.63	No	No	0	1	1
304	R:R:S49	R:R:V53	1.62	No	No	0	5	5
305	R:R:S49	R:R:V103	1.62	No	No	0	5	6
306	R:R:S265	R:R:V266	1.62	No	Yes	0	7	7
307	R:R:V53	R:R:V57	1.6	No	No	0	5	5
308	R:R:V57	R:R:V58	1.6	No	No	0	5	5
309	R:R:V272	R:R:V276	1.6	No	No	0	6	7
310	R:R:V311	R:R:V314	1.6	No	No	0	5	5
311	R:R:T230	R:R:V234	1.59	No	No	0	3	4
312	R:R:A240	R:R:L270	1.58	No	Yes	0	5	8
313	R:R:I286	R:R:V308	1.54	No	No	0	5	4
314	R:R:H150	R:R:P151	1.53	No	No	0	6	8
315	R:R:L301	R:R:S298	1.5	No	No	0	1	1
316	R:R:L46	R:R:V50	1.49	No	No	0	2	6
317	R:R:L307	R:R:V311	1.49	No	No	0	1	5
318	R:R:P261	R:R:R260	1.44	No	No	0	3	3
319	R:R:I70	R:R:L71	1.43	Yes	No	0	7	3
320	R:R:I279	R:R:L275	1.43	No	No	0	5	4
321	R:R:K155	R:R:L156	1.41	No	No	0	4	3
322	R:R:L330	R:R:M269	1.41	No	No	0	7	8
323	R:R:P193	R:R:Y191	1.39	No	No	0	1	1
324	R:R:L125	R:R:L97	1.38	No	No	0	4	5
325	R:R:L238	R:R:L241	1.38	No	No	0	4	3
326	R:R:I258	R:R:Q259	1.37	No	No	0	4	3
327	R:R:K77	R:R:Q74	1.36	No	No	0	7	6
328	R:R:F334	R:R:S331	1.32	Yes	No	0	8	8
329	R:R:D252	R:R:E253	1.3	No	No	0	2	3
330	R:R:R161	R:R:T159	1.29	No	No	0	3	7
331	R:R:R162	R:R:T159	1.29	Yes	No	0	4	7
332	R:R:T80	R:R:Y83	1.25	No	Yes	0	8	7
333	R:R:I169	R:R:R165	1.25	No	No	0	4	2
334	R:R:F126	R:R:L97	1.22	No	No	0	6	5
335	R:R:F271	R:R:L275	1.22	No	No	0	5	4
336	R:R:F192	R:R:H190	1.13	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F21	11.3725	4	1	0
2	L:L:R22	6.4075	4	3	0
3	L:L:R24	10.298	5	1	0
4	L:L:N25	12.33	4	1	0
5	R:R:V48	7.045	4	1	6
6	R:R:Y52	7.106	5	1	7
7	R:R:F56	6.8975	4	0	6
8	R:R:N63	7.485	4	0	9
9	R:R:I70	4.475	4	2	7
10	R:R:H73	4.598	5	2	5
11	R:R:M76	7.20333	6	2	7
12	R:R:N81	7.895	4	2	8
13	R:R:Y82	6.83	4	4	5
14	R:R:Y83	5.99	6	0	7
15	R:R:L87	5.1125	4	1	9
16	R:R:D91	7.802	5	0	9
17	R:R:M99	6.366	5	1	7
18	R:R:E102	9.1625	4	1	6
19	R:R:M106	3.975	4	1	5
20	R:R:F114	6.0125	4	0	7
21	R:R:E127	8.6925	4	1	4
22	R:R:I137	6.51	4	1	8
23	R:R:Y145	9.395	4	0	8
24	R:R:R162	6.0075	4	0	4
25	R:R:F177	4.7375	4	7	4
26	R:R:N181	7.49167	6	1	4
27	R:R:I184	4.795	4	0	5
28	R:R:Y213	9.552	5	1	2
29	R:R:I217	6.356	5	1	5
30	R:R:L223	2.8775	4	7	4
31	R:R:F224	9.025	4	7	5
32	R:R:L235	7.095	4	0	8
33	R:R:Y236	7.05833	6	1	9
34	R:R:M239	4.9775	4	1	9
35	R:R:V266	2.3225	4	0	7
36	R:R:L270	5.13	4	1	8
37	R:R:F277	4.764	5	1	9
38	R:R:W281	6.65667	6	1	8
39	R:R:F284	9.935	4	1	6
40	R:R:R288	7.10714	7	1	5
41	R:R:F290	7.47	4	0	4
42	R:R:F316	8.074	5	1	8
43	R:R:Y317	8.848	5	1	7
44	R:R:I326	5.1825	4	1	8
45	R:R:Y327	6.975	6	1	9
46	R:R:F334	5.49	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F19	L:L:F21	59.6585	12.86	No	Yes	1	0	0
2	L:L:F21	R:R:H309	38.5543	19.23	Yes	No	1	0	4
3	L:L:R24	R:R:H309	19.4501	21.44	Yes	No	1	0	4
4	L:L:R24	R:R:D287	23.2603	7.15	Yes	No	1	0	5
5	R:R:D287	R:R:R288	33.8771	5.96	No	Yes	1	5	5
6	L:L:N25	R:R:R288	27.1237	6.03	Yes	Yes	1	0	5
7	L:L:N25	R:R:Y213	19.9673	11.63	Yes	Yes	1	0	2
8	L:L:P23	R:R:Y213	54.4718	5.56	No	Yes	0	0	2
9	L:L:P23	R:R:F291	51.6731	21.67	No	No	0	0	4
10	R:R:F291	R:R:W297	25.9678	17.04	No	No	0	4	1
11	L:L:L20	R:R:W297	11.7081	11.39	No	No	0	0	1
12	R:R:N181	R:R:R288	28.1048	3.62	Yes	Yes	1	4	5
13	R:R:N181	R:R:Y213	22.1652	4.65	Yes	Yes	1	4	2
14	R:R:I217	R:R:R288	26.4659	3.76	Yes	Yes	1	5	5
15	R:R:I217	R:R:Y213	20.743	13.3	Yes	Yes	1	5	2
16	L:L:F19	R:R:N109	58.0881	9.67	No	No	0	0	2
17	R:R:F284	R:R:R288	80.8617	16.03	Yes	Yes	1	6	5
18	R:R:F284	R:R:F316	22.3401	9.65	Yes	Yes	1	6	8
19	R:R:F316	R:R:Y317	57.2173	13.41	Yes	Yes	1	8	7
20	R:R:Y317	R:R:Y52	26.3898	6.95	Yes	Yes	1	7	7
21	R:R:M106	R:R:Y52	28.1086	3.59	Yes	Yes	1	5	7
22	L:L:F21	R:R:M106	26.5876	3.73	Yes	Yes	1	0	5
23	L:L:R22	R:R:N109	56.3845	4.82	Yes	No	0	0	2
24	L:L:R22	R:R:E105	49.4943	10.47	Yes	No	0	0	4
25	R:R:F316	R:R:V94	16.9709	3.93	Yes	No	0	8	7
26	R:R:S320	R:R:V94	15.3624	4.85	No	No	0	8	7
27	R:R:L95	R:R:S320	14.7806	4.5	No	No	0	7	8
28	R:R:G59	R:R:L95	12.2253	1.71	No	No	0	8	7
29	R:R:F56	R:R:M99	13.0884	11.2	Yes	Yes	0	6	7
30	R:R:D91	R:R:S320	19.6403	8.83	Yes	No	0	9	8
31	R:R:F284	R:R:W281	60.2365	5.01	Yes	Yes	1	6	8
32	R:R:F277	R:R:W281	100	5.01	Yes	Yes	1	9	8
33	R:R:F277	R:R:I137	74.5152	3.77	Yes	Yes	1	9	8
34	R:R:I137	R:R:Y327	66.8264	10.88	Yes	Yes	1	8	9
35	R:R:L84	R:R:Y327	49.9658	3.52	No	Yes	0	8	9
36	R:R:L84	R:R:N328	48.6197	15.1	No	No	0	8	7
37	R:R:F334	R:R:N328	45.7868	6.04	Yes	No	2	8	7
38	R:R:F334	R:R:M76	36.1586	4.98	Yes	Yes	2	8	7
39	R:R:I70	R:R:M76	10.8297	4.37	Yes	Yes	2	7	7
40	R:R:H73	R:R:M76	10.921	5.25	Yes	Yes	2	5	7
41	R:R:R144	R:R:Y327	44.1745	6.17	No	Yes	0	9	9
42	R:R:R144	R:R:V140	38.5543	6.54	No	No	0	9	9
43	R:R:V140	R:R:Y83	37.2766	2.52	No	Yes	0	9	7
44	R:R:E143	R:R:Y83	12.7158	13.47	No	Yes	0	8	7
45	R:R:I166	R:R:Y83	12.7196	8.46	No	Yes	0	5	7
46	R:R:E105	R:R:K122	47.7527	4.05	No	No	0	4	5
47	R:R:K122	R:R:L101	46.0681	5.64	No	No	0	5	5
48	R:R:F114	R:R:L101	44.3114	4.87	Yes	No	0	7	5
49	R:R:F114	R:R:L113	22.6367	6.09	Yes	No	0	7	3
50	R:R:L113	R:R:Y104	20.781	12.89	No	No	0	3	4
51	R:R:R108	R:R:Y104	17.0127	10.29	No	No	5	4	4
52	R:R:P111	R:R:R108	15.1685	10.09	No	No	0	4	4
53	R:R:P111	R:R:Y110	13.2824	2.78	No	No	0	4	4
54	R:R:S201	R:R:Y110	11.3887	7.63	No	No	0	2	4
55	R:R:F112	R:R:F114	15.2977	8.57	No	Yes	0	8	7
56	R:R:C119	R:R:F112	11.4952	4.19	No	No	6	9	8
57	R:R:E127	R:R:F131	17.2218	8.16	Yes	No	0	4	6
58	R:R:F131	R:R:F224	16.1267	19.29	No	Yes	0	6	5
59	R:R:F277	R:R:I232	31.5423	7.54	Yes	No	0	9	8
60	R:R:I232	R:R:S141	30.4472	6.19	No	No	0	8	9
61	R:R:L235	R:R:S141	15.2103	6.01	Yes	No	0	8	9
62	R:R:S141	R:R:Y236	18.8037	8.9	No	Yes	0	9	9
63	R:R:E143	R:R:R162	11.3241	9.3	No	Yes	0	8	4
64	R:R:I166	R:R:R162	11.3317	8.77	No	Yes	0	5	4
65	R:R:Q157	R:R:R162	14.2254	4.67	No	Yes	0	3	4
66	R:R:Q157	R:R:R153	11.4343	17.52	No	No	0	3	4
67	R:R:L270	R:R:Y236	19.5642	11.72	Yes	Yes	1	8	9
68	R:R:A240	R:R:L270	11.9895	1.58	No	Yes	0	5	8
69	R:R:A240	R:R:N267	10.3088	4.69	No	No	0	5	6
70	R:R:P283	R:R:S312	13.2406	3.56	No	No	0	9	7
71	R:R:F315	R:R:P283	11.7994	5.78	No	No	0	7	9
72	R:R:F291	R:R:F305	23.093	9.65	No	No	0	4	5
73	R:R:F290	R:R:F305	20.2259	17.15	Yes	No	0	4	5
74	R:R:V294	R:R:W297	11.6511	9.81	No	No	0	3	1
75	R:R:L301	R:R:S298	11.5864	1.5	No	No	0	1	1
76	R:R:E102	R:R:H309	20.2753	3.69	Yes	No	1	6	4
77	R:R:E102	R:R:Y317	23.8535	12.35	Yes	Yes	1	6	7
78	R:R:F316	R:R:W281	43.0603	8.02	Yes	Yes	1	8	8
79	R:R:D91	R:R:L87	20.2525	6.79	Yes	Yes	0	9	9
80	R:R:E127	R:R:R288	19.7429	10.47	Yes	Yes	1	4	5
81	R:R:L87	R:R:Y327	18.4653	3.52	Yes	Yes	1	9	9
82	R:R:R144	R:R:Y236	11.6321	7.2	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y18	R:R:E299	6.73	0	No	No	0	1	0	1
L:L:F19	R:R:N109	9.67	1	No	No	0	2	0	1
L:L:F19	R:R:N306	4.83	1	No	No	0	4	0	1
L:L:L20	R:R:W297	11.39	0	No	No	0	1	0	1
L:L:F21	R:R:M106	3.73	1	Yes	Yes	0	5	0	1
L:L:F21	R:R:N306	9.67	1	Yes	No	0	4	0	1
L:L:F21	R:R:H309	19.23	1	Yes	No	0	4	0	1
L:L:R22	R:R:E105	10.47	3	Yes	No	0	4	0	1
L:L:R22	R:R:N109	4.82	3	Yes	No	0	2	0	1
L:L:R22	R:R:T203	5.17	3	Yes	No	0	4	0	1
L:L:R22	R:R:T205	5.17	3	Yes	No	0	4	0	1
L:L:P23	R:R:Y213	5.56	0	No	Yes	0	2	0	1
L:L:P23	R:R:F291	21.67	0	No	No	0	4	0	1
L:L:R24	R:R:E102	11.63	1	Yes	Yes	0	6	0	1
L:L:R24	R:R:D287	7.15	1	Yes	No	0	5	0	1
L:L:R24	R:R:H309	21.44	1	Yes	No	0	4	0	1
L:L:R24	R:R:S312	5.27	1	Yes	No	0	7	0	1
L:L:R24	R:R:G313	6	1	Yes	No	0	5	0	1
L:L:N25	R:R:N181	16.35	1	Yes	Yes	0	4	0	1
L:L:N25	R:R:H185	15.31	1	Yes	No	0	5	0	1
L:L:N25	R:R:Y213	11.63	1	Yes	Yes	0	2	0	1
L:L:N25	R:R:R288	6.03	1	Yes	Yes	0	5	0	1
R:R:V48	R:R:Y52	8.83	1	Yes	Yes	6	7	2	2
R:R:M106	R:R:V48	6.09	1	Yes	Yes	5	6	1	2
R:R:E102	R:R:Y52	8.98	1	Yes	Yes	6	7	1	2
R:R:M106	R:R:Y52	3.59	1	Yes	Yes	5	7	1	2
R:R:Y317	R:R:Y52	6.95	1	Yes	Yes	7	7	2	2
R:R:E102	R:R:H309	3.69	1	Yes	No	6	4	1	1
R:R:E102	R:R:Y317	12.35	1	Yes	Yes	6	7	1	2
R:R:E105	R:R:K122	4.05	0	No	No	4	5	1	2
R:R:H185	R:R:T123	10.95	0	No	No	5	5	1	2
R:R:E127	R:R:N181	11.83	1	Yes	Yes	4	4	2	1
R:R:E127	R:R:R288	10.47	1	Yes	Yes	4	5	2	1
R:R:N181	R:R:Y213	4.65	1	Yes	Yes	4	2	1	1
R:R:I216	R:R:N181	4.25	0	No	Yes	5	4	2	1
R:R:I217	R:R:N181	4.25	1	Yes	Yes	5	4	2	1
R:R:N181	R:R:R288	3.62	1	Yes	Yes	4	5	1	1
R:R:H185	R:R:V206	4.15	0	No	No	5	4	1	2
R:R:K188	R:R:T205	7.51	0	No	No	1	4	2	1
R:R:T203	R:R:T205	4.71	3	No	No	4	4	1	1
R:R:V206	R:R:Y213	12.62	0	No	Yes	4	2	2	1
R:R:I217	R:R:Y213	13.3	1	Yes	Yes	5	2	2	1
R:R:I217	R:R:R288	3.76	1	Yes	Yes	5	5	2	1
R:R:R288	R:R:T220	3.88	1	Yes	No	5	4	1	2
R:R:P283	R:R:S312	3.56	0	No	No	9	7	2	1
R:R:F284	R:R:R288	16.03	1	Yes	Yes	6	5	2	1
R:R:D287	R:R:R288	5.96	1	No	Yes	5	5	1	1
R:R:D287	R:R:S312	8.83	1	No	No	5	7	1	1
R:R:F291	R:R:W297	17.04	0	No	No	4	1	1	1
R:R:F291	R:R:F305	9.65	0	No	No	4	5	1	2
R:R:V294	R:R:W297	9.81	0	No	No	3	1	2	1
L:L:L20	R:R:A302	3.15	0	No	No	0	1	0	1
R:R:F45	R:R:M106	2.49	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W55_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	297
Number of Links	336
Number of Hubs	46
Number of Links mediated by Hubs	163
Number of Communities	10
Number of Nodes involved in Communities	71
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	65526
Length Of Smallest Path	3
Average Path Length	13.827
Length of Longest Path	37
Minimum Path Strength	1.29
Average Path Strength	7.56117
Maximum Path Strength	20.335
Minimum Path Correlation	0.7
Average Path Correlation	0.950369
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	62.5334
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.964
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • signaling receptor binding • type 2 neuromedin U receptor binding • neuromedin U receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 neuromedin U receptor binding • multicellular organismal process • system process • positive regulation of smooth muscle contraction • regulation of system process • positive regulation of biological process • stomach smooth muscle contraction • regulation of stomach fundus smooth muscle contraction • regulation of gastro-intestinal system smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of multicellular organismal process • gastro-intestinal system smooth muscle contraction • regulation of biological process • stomach fundus smooth muscle contraction • biological regulation • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of gastro-intestinal system smooth muscle contraction • proximal stomach smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • positive regulation of multicellular organismal process • positive regulation of stomach fundus smooth muscle contraction • tonic smooth muscle contraction • localization • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • heart process • regulation of heart contraction • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • positive regulation of cytosolic calcium ion concentration • regulation of heat generation • homeostatic process • positive regulation of heat generation • heat generation • multicellular organismal-level homeostasis • temperature homeostasis • nervous system process • sensory perception of pain • regulation of nervous system process • sensory perception • positive regulation of nervous system process • regulation of sensory perception • regulation of sensory perception of pain • positive regulation of sensory perception of pain • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • behavior • circadian behavior • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • eating behavior • feeding behavior • energy homeostasis • regulation of localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of digestive system process • regulation of gastric acid secretion • regulation of transport • regulation of digestive system process • regulation of secretion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • regulation of grooming behavior • grooming behavior • regulation of gastric emptying • regulation of gastric motility • gastric emptying • negative regulation of gastric emptying • gastric motility • positive regulation of cell communication • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • intracellular protein localization • regulation of peptide hormone secretion • positive regulation of prolactin secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • positive regulation of protein localization • regulation of hormone secretion • regulation of peptide secretion • regulation of protein localization • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • prolactin secretion • cell-cell signaling • export from cell • regulation of protein transport • positive regulation of protein secretion • peptide transport • positive regulation of transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • positive regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure • regulation of blood pressure • positive regulation of blood pressure • negative regulation of feeding behavior • negative regulation of behavior • regulation of eating behavior • negative regulation of eating behavior • regulation of feeding behavior • trans-synaptic signaling • modulation of chemical synaptic transmission • positive regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • axon • synapse • neuron projection • axon terminus • presynapse • distal axon • terminal bouton • cell junction • neuron projection terminus • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • neuromedin U receptor activity • neuromedin U binding • neuropeptide binding • peptide binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • monoatomic anion transmembrane transporter activity • chloride transmembrane transporter activity • gated channel activity • monoatomic ion channel activity • intracellularly calcium-gated channel activity • intracellularly calcium-gated chloride channel activity • ligand-gated monoatomic anion channel activity • ligand-gated channel activity • ligand-gated monoatomic ion channel activity • passive transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • monoatomic anion channel activity • transporter activity • transmembrane transporter activity • chloride channel activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • response to stress • multicellular organismal response to stress • response to pain • organic anion transport • carboxylic acid transport • arachidonate transport • lipid localization • lipid transport • organic acid transport • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • icosanoid secretion • long-chain fatty acid transport • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • reduction of food intake in response to dietary excess • response to nutrient levels • response to dietary excess • developmental process • multicellular organism development • central nervous system development • anatomical structure development • nervous system development • system development • phospholipase C-activating G protein-coupled receptor signaling pathway • periplasmic space • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ4
Sequence	>7W55_nogp_Chain_R S H F F L P V S V V Y V P I F V V G V I G N V L V C L V I L Q H Q A M K T P T N Y Y L F S L A V S D L L V L L L G M P L E V Y E M W R N Y P F L F G P V G C Y F K T A L F E T V C F A S I L S I T T V S V E R Y V A I L H P F R A K L Q S T R R R A L R I L G I V W G F S V L F S L P N T S I H G I K F H Y F P N G S G S A T C T V I K P M W I Y N F I I Q V T S F L F Y L L P M T V I S V L Y Y L M A L R L K K D K S L E A D E G N A N I Q R P C R K S V N K M L F V L V L V F A I C W A P F H I D R L F F S F V E E W S E S L A A V F N L V H V V S G V F F Y L S S A V N P I I Y N L L S R R F Q A A F Q N V I S S F H K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7W55	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W55 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-		2.8	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W57	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-S	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W57 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-S	-		3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7XK8	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-	Gi1/β1/γ2	3.3	2023-02-22	doi.org/10.1038/s41467-022-34814-4
	7XK8 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-		3.3	2023-02-22	doi.org/10.1038/s41467-022-34814-4

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