psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F4	L:L:R2	6.41	Yes	No	1	0	0
2	L:L:L6	L:L:R2	7.29	No	No	1	0	0
3	L:L:F4	L:L:L6	3.65	Yes	No	1	0	0
4	L:L:F4	R:R:E299	5.83	Yes	No	0	0	1
5	L:L:F4	R:R:A302	5.55	Yes	No	0	0	1
6	L:L:F5	L:L:F7	13.93	No	Yes	0	0	0
7	L:L:F5	R:R:N109	7.25	No	No	0	0	2
8	L:L:L6	R:R:W297	20.5	No	Yes	1	0	1
9	L:L:F7	R:R:F44	6.43	Yes	Yes	1	0	1
10	L:L:F7	R:R:N306	9.67	Yes	No	1	0	4
11	L:L:F7	R:R:H309	18.1	Yes	Yes	1	0	4
12	L:L:R8	R:R:E105	12.79	No	No	0	0	4
13	L:L:R8	R:R:N109	13.26	No	No	0	0	2
14	L:L:R8	R:R:T203	10.35	No	No	0	0	4
15	L:L:P9	R:R:F291	20.23	No	No	0	0	4
16	L:L:R10	R:R:E102	11.63	Yes	Yes	1	0	6
17	L:L:R10	R:R:F284	4.28	Yes	Yes	1	0	6
18	L:L:R10	R:R:D287	5.96	Yes	Yes	1	0	5
19	L:L:R10	R:R:H309	19.18	Yes	Yes	1	0	4
20	L:L:R10	R:R:G313	6	Yes	No	0	0	5
21	L:L:R10	R:R:F316	4.28	Yes	Yes	1	0	8
22	L:L:R10	R:R:Y317	4.12	Yes	Yes	1	0	7
23	L:L:N11	R:R:N181	4.09	Yes	No	0	0	4
24	L:L:N11	R:R:H185	8.93	Yes	No	0	0	5
25	L:L:N11	R:R:Y213	5.81	Yes	Yes	0	0	2
26	L:L:N11	R:R:R288	9.64	Yes	No	0	0	5
27	R:R:F44	R:R:H43	15.84	Yes	No	0	1	5
28	R:R:F44	R:R:V48	3.93	Yes	Yes	1	1	6
29	R:R:F44	R:R:N306	3.62	Yes	No	1	1	4
30	R:R:F44	R:R:L307	3.65	Yes	No	0	1	1
31	R:R:F44	R:R:V310	9.18	Yes	No	1	1	4
32	R:R:F45	R:R:L46	4.87	Yes	No	0	4	2
33	R:R:F45	R:R:S49	7.93	Yes	No	0	4	5
34	R:R:F45	R:R:M106	4.98	Yes	No	0	4	5
35	R:R:F45	R:R:W107	11.02	Yes	No	0	4	4
36	R:R:V48	R:R:Y52	8.83	Yes	Yes	1	6	7
37	R:R:M106	R:R:V48	6.09	No	Yes	0	5	6
38	R:R:V310	R:R:V48	4.81	No	Yes	1	4	6
39	R:R:M99	R:R:Y52	10.78	Yes	Yes	1	7	7
40	R:R:E102	R:R:Y52	8.98	Yes	Yes	1	6	7
41	R:R:V314	R:R:Y52	3.79	No	Yes	0	5	7
42	R:R:Y317	R:R:Y52	6.95	Yes	Yes	1	7	7
43	R:R:P54	R:R:V53	3.53	No	No	0	4	5
44	R:R:F56	R:R:V60	7.87	No	No	0	6	6
45	R:R:F56	R:R:M99	9.95	No	Yes	0	6	7
46	R:R:G59	R:R:V58	3.68	No	No	0	8	5
47	R:R:L92	R:R:V60	4.47	Yes	No	0	7	6
48	R:R:D91	R:R:N63	6.73	Yes	No	0	9	9
49	R:R:L92	R:R:N63	4.12	Yes	No	0	7	9
50	R:R:N63	R:R:P324	14.66	No	No	0	9	9
51	R:R:F338	R:R:L65	6.09	No	No	0	6	7
52	R:R:N328	R:R:V66	13.3	No	Yes	3	7	9
53	R:R:F334	R:R:V66	6.55	Yes	Yes	3	8	9
54	R:R:C67	R:R:F85	4.19	No	No	0	7	5
55	R:R:F334	R:R:V69	9.18	Yes	No	0	8	8
56	R:R:I70	R:R:M76	8.75	No	Yes	3	7	7
57	R:R:I70	R:R:N81	4.25	No	No	3	7	8
58	R:R:A75	R:R:H73	5.85	No	No	0	5	5
59	R:R:A337	R:R:H73	4.39	No	No	0	5	5
60	R:R:H73	R:R:N340	6.38	No	No	0	5	5
61	R:R:K77	R:R:Q74	8.14	No	No	0	7	6
62	R:R:Q74	R:R:T78	4.25	No	No	0	6	8
63	R:R:M76	R:R:N81	7.01	Yes	No	3	7	8
64	R:R:M76	R:R:R333	8.69	Yes	No	3	7	6
65	R:R:P79	R:R:T78	5.25	No	No	0	6	8
66	R:R:P79	R:R:R333	5.76	No	No	0	6	6
67	R:R:T80	R:R:Y83	8.74	No	Yes	5	8	7
68	R:R:E143	R:R:T80	5.64	No	No	5	8	8
69	R:R:S158	R:R:T80	4.8	No	No	0	6	8
70	R:R:N81	R:R:R333	12.05	No	No	3	8	6
71	R:R:R160	R:R:Y82	14.4	No	No	0	2	5
72	R:R:L164	R:R:Y82	7.03	No	No	0	3	5
73	R:R:T139	R:R:Y83	7.49	No	Yes	0	8	7
74	R:R:E143	R:R:Y83	15.71	No	Yes	5	8	7
75	R:R:A163	R:R:Y83	4	No	Yes	0	7	7
76	R:R:I166	R:R:Y83	7.25	No	Yes	0	5	7
77	R:R:L84	R:R:Y327	3.52	No	Yes	0	8	9
78	R:R:L84	R:R:N328	10.98	No	No	0	8	7
79	R:R:F85	R:R:V89	6.55	No	No	0	5	6
80	R:R:S136	R:R:S86	4.89	No	No	0	8	9
81	R:R:L167	R:R:S86	7.51	No	No	6	7	9
82	R:R:S86	R:R:W171	6.18	No	Yes	6	9	9
83	R:R:D91	R:R:L87	5.43	Yes	No	0	9	9
84	R:R:I137	R:R:L87	4.28	Yes	No	2	8	9
85	R:R:L87	R:R:Y327	5.86	No	Yes	2	9	9
86	R:R:S133	R:R:S90	6.52	No	No	0	9	8
87	R:R:S90	R:R:W171	3.71	No	Yes	0	8	9
88	R:R:D91	R:R:S133	5.89	Yes	No	0	9	9
89	R:R:D91	R:R:S320	11.78	Yes	No	0	9	8
90	R:R:D91	R:R:N323	8.08	Yes	No	0	9	9
91	R:R:L92	R:R:L96	5.54	Yes	No	0	7	5
92	R:R:L93	R:R:V129	5.96	No	No	0	7	8
93	R:R:F126	R:R:V94	6.55	No	No	0	6	7
94	R:R:V129	R:R:V94	4.81	No	No	0	8	7
95	R:R:S320	R:R:V94	4.85	No	No	0	8	7
96	R:R:L95	R:R:S320	6.01	No	No	0	7	8
97	R:R:F126	R:R:L97	10.96	No	No	0	6	5
98	R:R:F126	R:R:G98	6.02	No	No	0	6	6
99	R:R:G98	R:R:Y317	4.35	No	Yes	0	6	7
100	R:R:M99	R:R:Y317	14.37	Yes	Yes	1	7	7
101	R:R:K122	R:R:L101	7.05	No	No	0	5	5
102	R:R:E102	R:R:H309	3.69	Yes	Yes	1	6	4
103	R:R:E102	R:R:Y317	11.22	Yes	Yes	1	6	7
104	R:R:R108	R:R:Y104	12.35	No	No	0	4	4
105	R:R:E105	R:R:K122	5.4	No	No	0	4	5
106	R:R:R108	R:R:W107	11	No	No	0	4	4
107	R:R:P111	R:R:R108	5.76	No	No	0	4	4
108	R:R:P111	R:R:Y110	4.17	No	No	0	4	4
109	R:R:S201	R:R:Y110	15.26	No	No	0	2	4
110	R:R:F112	R:R:F114	8.57	No	No	0	8	7
111	R:R:C204	R:R:F112	8.38	No	No	0	9	8
112	R:R:F114	R:R:L113	18.27	No	No	0	7	3
113	R:R:G115	R:R:P116	4.06	No	No	0	7	3
114	R:R:I187	R:R:P116	5.08	No	No	0	6	3
115	R:R:C119	R:R:C204	5.46	No	No	0	9	9
116	R:R:T123	R:R:T182	4.71	No	No	0	5	5
117	R:R:H185	R:R:T123	9.58	No	No	0	5	5
118	R:R:E127	R:R:F131	12.83	No	No	0	4	6
119	R:R:E127	R:R:S178	7.19	No	No	0	4	7
120	R:R:E127	R:R:N181	14.46	No	No	0	4	4
121	R:R:T128	R:R:V175	4.76	No	No	0	5	4
122	R:R:C130	R:R:W281	5.22	No	Yes	0	7	8
123	R:R:F131	R:R:F224	25.72	No	Yes	0	6	5
124	R:R:A132	R:R:W171	7.78	No	Yes	0	7	9
125	R:R:I134	R:R:W281	15.27	No	Yes	0	8	8
126	R:R:L135	R:R:V170	5.96	No	No	0	5	7
127	R:R:F224	R:R:L135	4.87	Yes	No	0	5	5
128	R:R:F277	R:R:I137	5.02	Yes	Yes	0	9	8
129	R:R:I137	R:R:N323	4.25	Yes	No	2	8	9
130	R:R:I137	R:R:Y327	6.04	Yes	Yes	2	8	9
131	R:R:R144	R:R:V140	7.85	Yes	No	0	9	9
132	R:R:I232	R:R:S141	7.74	No	No	0	8	9
133	R:R:L235	R:R:S141	4.5	Yes	No	0	8	9
134	R:R:S141	R:R:Y236	13.99	No	Yes	0	9	9
135	R:R:E143	R:R:R162	4.65	No	Yes	0	8	4
136	R:R:R144	R:R:Y236	9.26	Yes	Yes	2	9	9
137	R:R:L273	R:R:R144	3.64	Yes	Yes	2	8	9
138	R:R:R144	R:R:Y327	4.12	Yes	Yes	2	9	9
139	R:R:L149	R:R:Y145	14.07	No	Yes	0	7	8
140	R:R:L235	R:R:Y145	15.24	Yes	Yes	0	8	8
141	R:R:L238	R:R:Y145	7.03	No	Yes	0	4	8
142	R:R:M239	R:R:Y145	3.59	Yes	Yes	0	9	8
143	R:R:I148	R:R:M239	7.29	No	Yes	0	8	9
144	R:R:L149	R:R:R242	15.79	No	No	0	7	5
145	R:R:H150	R:R:R153	6.77	No	No	0	6	4
146	R:R:Q157	R:R:R162	17.52	No	Yes	0	3	4
147	R:R:R161	R:R:R165	8.53	No	No	0	3	2
148	R:R:I166	R:R:R162	7.52	No	Yes	0	5	4
149	R:R:L167	R:R:W171	4.56	No	Yes	6	7	9
150	R:R:F173	R:R:I169	5.02	No	No	0	4	4
151	R:R:F177	R:R:F224	9.65	No	Yes	7	4	5
152	R:R:I216	R:R:P180	5.08	No	No	0	5	8
153	R:R:I216	R:R:N181	4.25	No	No	0	5	4
154	R:R:I184	R:R:V206	7.68	No	No	4	5	4
155	R:R:I184	R:R:K208	5.82	No	No	0	5	4
156	R:R:I184	R:R:Y213	4.84	No	Yes	4	5	2
157	R:R:H185	R:R:V206	4.15	No	No	0	5	4
158	R:R:G186	R:R:I207	3.53	No	No	0	4	3
159	R:R:H190	R:R:S201	4.18	No	No	0	1	2
160	R:R:V206	R:R:Y213	16.4	No	Yes	4	4	2
161	R:R:K208	R:R:P209	6.69	No	No	0	4	6
162	R:R:I212	R:R:K208	5.82	No	No	0	2	4
163	R:R:M210	R:R:Y213	8.38	No	Yes	0	3	2
164	R:R:I212	R:R:W211	3.52	No	No	0	2	1
165	R:R:F215	R:R:W211	4.01	No	No	0	3	1
166	R:R:I217	R:R:Y213	13.3	Yes	Yes	0	5	2
167	R:R:N214	R:R:Q218	11.88	No	No	0	3	4
168	R:R:N214	R:R:S292	5.96	No	No	8	3	4
169	R:R:F293	R:R:N214	7.25	No	No	8	4	3
170	R:R:I217	R:R:R288	11.27	Yes	No	0	5	5
171	R:R:I217	R:R:S292	4.64	Yes	No	0	5	4
172	R:R:H285	R:R:S221	5.58	No	No	0	7	5
173	R:R:L289	R:R:S221	6.01	No	No	0	6	5
174	R:R:F222	R:R:L223	6.09	No	Yes	0	4	4
175	R:R:L226	R:R:Y225	3.52	No	Yes	0	4	8
176	R:R:M229	R:R:Y225	4.79	No	Yes	0	7	8
177	R:R:A282	R:R:Y225	5.34	No	Yes	0	6	8
178	R:R:H285	R:R:Y225	6.53	No	Yes	0	7	8
179	R:R:F277	R:R:M229	4.98	Yes	No	0	9	7
180	R:R:F277	R:R:I232	7.54	Yes	No	0	9	8
181	R:R:M239	R:R:Y236	4.79	Yes	Yes	2	9	9
182	R:R:L270	R:R:Y236	5.86	Yes	Yes	2	8	9
183	R:R:L273	R:R:Y236	4.69	Yes	Yes	2	8	9
184	R:R:V274	R:R:Y236	5.05	No	Yes	0	8	9
185	R:R:L241	R:R:Y237	16.41	No	No	0	3	4
186	R:R:L270	R:R:M239	4.24	Yes	Yes	2	8	9
187	R:R:K245	R:R:R242	6.19	No	No	0	4	5
188	R:R:L243	R:R:V266	4.47	No	No	0	8	7
189	R:R:D246	R:R:S248	8.83	No	No	0	6	4
190	R:R:K247	R:R:Q259	4.07	No	No	0	4	3
191	R:R:D252	R:R:N255	5.39	No	No	0	2	3
192	R:R:G254	R:R:R260	4.5	No	No	0	1	3
193	R:R:N257	R:R:Q259	15.85	No	No	0	3	3
194	R:R:P261	R:R:R260	4.32	No	No	0	3	3
195	R:R:R260	R:R:R263	6.4	No	No	0	3	7
196	R:R:K268	R:R:V272	4.55	No	No	0	6	6
197	R:R:L330	R:R:M269	4.24	No	No	0	7	8
198	R:R:F271	R:R:L275	14.61	No	No	0	5	4
199	R:R:I326	R:R:L273	4.28	Yes	Yes	2	8	8
200	R:R:L273	R:R:Y327	8.21	Yes	Yes	2	8	9
201	R:R:I279	R:R:L275	4.28	No	No	0	5	4
202	R:R:I326	R:R:V276	4.61	Yes	No	0	8	7
203	R:R:F277	R:R:W281	9.02	Yes	Yes	0	9	8
204	R:R:C280	R:R:S319	6.89	No	No	0	8	9
205	R:R:F284	R:R:W281	6.01	Yes	Yes	1	6	8
206	R:R:F316	R:R:W281	7.02	Yes	Yes	1	8	8
207	R:R:S319	R:R:W281	4.94	No	Yes	0	9	8
208	R:R:P283	R:R:S312	3.56	No	No	0	9	7
209	R:R:F315	R:R:P283	7.22	No	No	0	7	9
210	R:R:F284	R:R:H285	9.05	Yes	No	0	6	7
211	R:R:F284	R:R:R288	11.76	Yes	No	0	6	5
212	R:R:F284	R:R:F316	13.93	Yes	Yes	1	6	8
213	R:R:D287	R:R:F305	7.17	Yes	Yes	1	5	5
214	R:R:D287	R:R:H309	15.13	Yes	Yes	1	5	4
215	R:R:F293	R:R:L289	4.87	No	No	0	4	6
216	R:R:F290	R:R:L301	4.87	Yes	No	0	4	1
217	R:R:F290	R:R:F305	15	Yes	Yes	0	4	5
218	R:R:F290	R:R:V308	5.24	Yes	No	0	4	4
219	R:R:F291	R:R:W297	5.01	No	Yes	1	4	1
220	R:R:F291	R:R:F305	9.65	No	Yes	1	4	5
221	R:R:F293	R:R:S292	3.96	No	No	8	4	4
222	R:R:V294	R:R:W297	22.07	No	Yes	0	3	1
223	R:R:L301	R:R:V294	5.96	No	No	0	1	3
224	R:R:F305	R:R:W297	11.02	Yes	Yes	1	5	1
225	R:R:F316	R:R:Y317	11.35	Yes	Yes	1	8	7
226	R:R:I326	R:R:V322	4.61	Yes	No	0	8	6
227	R:R:N323	R:R:Y327	5.81	No	Yes	2	9	9
228	R:R:I325	R:R:L330	4.28	No	No	0	7	7
229	R:R:I326	R:R:Y327	6.04	Yes	Yes	2	8	9
230	R:R:F334	R:R:N328	9.67	Yes	No	3	8	7
231	R:R:F334	R:R:L329	6.09	Yes	No	0	8	6
232	R:R:F338	R:R:I342	11.3	No	No	0	6	5
233	R:R:F345	R:R:S344	9.25	No	No	0	1	5
234	R:R:A132	R:R:S174	3.42	No	No	0	7	8
235	R:R:A88	R:R:V66	3.39	No	Yes	0	9	9
236	R:R:I134	R:R:P228	3.39	No	No	0	8	9
237	R:R:L227	R:R:P228	3.28	No	No	0	6	9
238	R:R:C119	R:R:I187	3.27	No	No	0	9	6
239	R:R:E253	R:R:G254	3.27	No	No	0	3	1
240	R:R:S49	R:R:V103	3.23	No	No	0	5	6
241	R:R:S233	R:R:V274	3.23	No	No	0	4	8
242	R:R:A337	R:R:M76	3.22	No	Yes	0	5	7
243	R:R:A278	R:R:M229	3.22	No	No	0	6	7
244	R:R:V314	R:R:V51	3.21	No	No	0	5	5
245	R:R:S174	R:R:T128	3.2	No	No	0	8	5
246	R:R:S178	R:R:T128	3.2	No	No	0	7	5
247	R:R:A240	R:R:N267	3.13	No	No	0	5	6
248	R:R:I70	R:R:V66	3.07	No	Yes	3	7	9
249	R:R:I232	R:R:T138	3.04	No	No	0	8	7
250	R:R:I217	R:R:T220	3.04	Yes	No	0	5	4
251	R:R:K188	R:R:T205	3	No	No	0	1	4
252	R:R:L68	R:R:V64	2.98	No	No	0	4	4
253	R:R:L92	R:R:V64	2.98	Yes	No	0	7	4
254	R:R:L65	R:R:V69	2.98	No	No	0	7	8
255	R:R:L93	R:R:V89	2.98	No	No	0	7	6
256	R:R:L235	R:R:V142	2.98	Yes	No	0	8	6
257	R:R:L223	R:R:V219	2.98	Yes	No	0	4	3
258	R:R:L235	R:R:V231	2.98	Yes	No	0	8	7
259	R:R:L238	R:R:V234	2.98	No	No	0	4	4
260	R:R:L270	R:R:V266	2.98	Yes	No	0	8	7
261	R:R:L318	R:R:V322	2.98	No	No	0	5	6
262	R:R:D287	R:R:S312	2.94	Yes	No	0	5	7
263	R:R:I55	R:R:M99	2.92	No	Yes	0	7	7
264	L:L:F4	L:L:P3	2.89	Yes	No	0	0	0
265	R:R:K155	R:R:L156	2.82	No	No	0	4	3
266	R:R:A202	R:R:F189	2.77	No	No	0	5	1
267	R:R:A163	R:R:Y82	2.67	No	No	0	7	5
268	R:R:F334	R:R:S331	2.64	Yes	No	0	8	8
269	R:R:F121	R:R:V117	2.62	No	No	0	5	3
270	R:R:F290	R:R:V304	2.62	Yes	No	0	4	4
271	R:R:F315	R:R:V311	2.62	No	No	0	7	5
272	R:R:H150	R:R:L149	2.57	No	No	0	6	7
273	R:R:F189	R:R:I187	2.51	No	No	0	1	6
274	R:R:F315	R:R:I279	2.51	No	No	0	7	5
275	R:R:F112	R:R:K122	2.48	No	No	0	8	5
276	R:R:F177	R:R:L223	2.44	No	Yes	7	4	4
277	R:R:F222	R:R:L226	2.44	No	No	0	4	4
278	R:R:F224	R:R:L223	2.44	Yes	Yes	7	5	4
279	R:R:Q157	R:R:R153	2.34	No	No	0	3	4
280	R:R:F173	R:R:F177	2.14	No	No	0	4	4
281	R:R:C119	R:R:G186	1.96	No	No	0	9	4
282	R:R:A321	R:R:G59	1.95	No	No	0	7	8
283	R:R:G118	R:R:V117	1.84	No	No	0	5	3
284	R:R:G172	R:R:V175	1.84	No	No	0	5	4
285	R:R:A147	R:R:A154	1.79	No	No	0	8	6
286	R:R:G62	R:R:I61	1.76	No	No	0	8	5
287	R:R:G59	R:R:L95	1.71	No	No	0	8	7
288	R:R:G62	R:R:L65	1.71	No	No	0	8	7
289	R:R:A124	R:R:S178	1.71	No	No	0	7	7
290	R:R:C262	R:R:V266	1.71	No	No	0	5	7
291	R:R:M99	R:R:P100	1.68	Yes	No	0	7	8
292	R:R:L46	R:R:P47	1.64	No	No	0	2	4
293	R:R:L179	R:R:P180	1.64	No	No	0	4	8
294	R:R:C262	R:R:I258	1.64	No	No	0	5	4
295	R:R:V57	R:R:V58	1.6	No	No	0	5	5
296	R:R:V341	R:R:V69	1.6	No	No	0	6	8
297	R:R:S183	R:R:T182	1.6	No	No	0	5	5
298	R:R:V272	R:R:V276	1.6	No	No	0	6	7
299	R:R:A240	R:R:L270	1.58	No	Yes	0	5	8
300	R:R:A256	R:R:N255	1.56	No	No	0	2	3
301	R:R:I286	R:R:V308	1.54	No	No	0	5	4
302	R:R:H150	R:R:P151	1.53	No	No	0	6	8
303	R:R:K247	R:R:S248	1.53	No	No	0	4	4
304	R:R:I207	R:R:T205	1.52	No	No	0	3	4
305	R:R:F114	R:R:G118	1.51	No	No	0	7	5
306	R:R:D252	R:R:S248	1.47	No	No	0	2	4
307	R:R:F192	R:R:P193	1.44	No	No	0	3	1
308	R:R:Q72	R:R:V341	1.43	No	No	0	4	6
309	R:R:Q157	R:R:V146	1.43	No	No	0	3	5
310	R:R:I325	R:R:L329	1.43	No	No	0	7	6
311	R:R:I326	R:R:L330	1.43	Yes	No	0	8	7
312	R:R:I258	R:R:N257	1.42	No	No	0	4	3
313	R:R:L125	R:R:L97	1.38	No	No	0	4	5
314	R:R:I342	R:R:Q339	1.37	No	No	0	5	4
315	R:R:R161	R:R:T159	1.29	No	No	0	3	7
316	R:R:R162	R:R:T159	1.29	Yes	No	0	4	7
317	R:R:K264	R:R:R263	1.24	No	No	0	6	7
318	R:R:F85	R:R:L71	1.22	No	No	0	5	3
319	R:R:F173	R:R:L176	1.22	No	No	0	4	4
320	R:R:F345	R:R:Q72	1.17	No	No	0	1	4
321	R:R:F189	R:R:Y191	1.03	No	No	0	1	1
322	R:R:F192	R:R:Y191	1.03	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F4	4.866	5	1	0
2	L:L:F7	12.0325	4	1	0
3	L:L:R10	7.92143	7	1	0
4	L:L:N11	7.1175	4	0	0
5	R:R:F44	7.10833	6	1	1
6	R:R:F45	7.2	4	0	4
7	R:R:V48	5.915	4	1	6
8	R:R:Y52	7.866	5	1	7
9	R:R:V66	6.5775	4	3	9
10	R:R:M76	6.9175	4	3	7
11	R:R:Y83	8.638	5	5	7
12	R:R:D91	7.582	5	0	9
13	R:R:L92	4.2775	4	0	7
14	R:R:M99	7.94	5	1	7
15	R:R:E102	8.88	4	1	6
16	R:R:I137	4.8975	4	2	8
17	R:R:R144	6.2175	4	2	9
18	R:R:Y145	9.9825	4	0	8
19	R:R:R162	7.745	4	0	4
20	R:R:W171	5.5575	4	6	9
21	R:R:Y213	9.746	5	4	2
22	R:R:I217	8.0625	4	0	5
23	R:R:L223	3.4875	4	7	4
24	R:R:F224	10.67	4	7	5
25	R:R:Y225	5.045	4	0	8
26	R:R:L235	6.425	4	0	8
27	R:R:Y236	7.27333	6	2	9
28	R:R:M239	4.9775	4	2	9
29	R:R:L270	3.665	4	2	8
30	R:R:L273	5.205	4	2	8
31	R:R:F277	6.64	4	0	9
32	R:R:W281	7.91333	6	1	8
33	R:R:F284	9.006	5	1	6
34	R:R:D287	7.8	4	1	5
35	R:R:F290	6.9325	4	0	4
36	R:R:W297	14.65	4	1	1
37	R:R:F305	10.71	4	1	5
38	R:R:H309	14.025	4	1	4
39	R:R:F316	9.145	4	1	8
40	R:R:Y317	8.72667	6	1	7
41	R:R:I326	4.194	5	2	8
42	R:R:Y327	5.65714	7	2	9
43	R:R:F334	6.826	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L6	R:R:W297	11.6477	20.5	No	Yes	1	0	1
2	R:R:F305	R:R:W297	15.3575	11.02	Yes	Yes	1	5	1
3	R:R:D287	R:R:F305	30.4343	7.17	Yes	Yes	1	5	5
4	L:L:F7	R:R:H309	56.7276	18.1	Yes	Yes	1	0	4
5	L:L:F5	L:L:F7	51.3249	13.93	No	Yes	0	0	0
6	L:L:F5	R:R:N109	49.5214	7.25	No	No	0	0	2
7	L:L:R8	R:R:N109	47.7021	13.26	No	No	0	0	2
8	L:L:R8	R:R:E105	44.0437	12.79	No	No	0	0	4
9	L:L:R10	R:R:D287	38.6173	5.96	Yes	Yes	1	0	5
10	L:L:R10	R:R:F284	62.1262	4.28	Yes	Yes	1	0	6
11	L:L:R10	R:R:F316	31.3874	4.28	Yes	Yes	1	0	8
12	L:L:R10	R:R:Y317	19.898	4.12	Yes	Yes	1	0	7
13	R:R:F284	R:R:R288	53.0414	11.76	Yes	No	0	6	5
14	L:L:N11	R:R:R288	33.8712	9.64	Yes	No	0	0	5
15	L:L:N11	R:R:N181	17.1571	4.09	Yes	No	0	0	4
16	L:L:N11	R:R:Y213	13.1743	5.81	Yes	Yes	0	0	2
17	R:R:I217	R:R:R288	19.6409	11.27	Yes	No	0	5	5
18	R:R:I217	R:R:Y213	12.5138	13.3	Yes	Yes	0	5	2
19	R:R:V48	R:R:Y52	29.4218	8.83	Yes	Yes	1	6	7
20	R:R:Y317	R:R:Y52	23.0857	6.95	Yes	Yes	1	7	7
21	R:R:M106	R:R:V48	25.5379	6.09	No	Yes	0	5	6
22	R:R:F45	R:R:M106	23.6197	4.98	Yes	No	0	4	5
23	R:R:F45	R:R:W107	13.91	11.02	Yes	No	0	4	4
24	R:R:G98	R:R:Y317	19.1188	4.35	No	Yes	0	6	7
25	R:R:F126	R:R:G98	18.1854	6.02	No	No	0	6	6
26	R:R:F126	R:R:V94	18.8143	6.55	No	No	0	6	7
27	R:R:S320	R:R:V94	22.9948	4.85	No	No	0	8	7
28	R:R:L95	R:R:S320	13.7992	6.01	No	No	0	7	8
29	R:R:G59	R:R:L95	11.0544	1.71	No	No	0	8	7
30	R:R:F284	R:R:W281	56.1541	6.01	Yes	Yes	1	6	8
31	R:R:F277	R:R:W281	100	9.02	Yes	Yes	0	9	8
32	R:R:F277	R:R:I137	61.1968	5.02	Yes	Yes	0	9	8
33	R:R:D91	R:R:L87	30.8258	5.43	Yes	No	0	9	9
34	R:R:F316	R:R:W281	45.5861	7.02	Yes	Yes	1	8	8
35	R:R:D91	R:R:N323	30.8258	8.08	Yes	No	0	9	9
36	R:R:D91	R:R:S320	29.8054	11.78	Yes	No	0	9	8
37	R:R:L92	R:R:N63	10.9714	4.12	Yes	No	0	7	9
38	R:R:I137	R:R:Y327	43.482	6.04	Yes	Yes	2	8	9
39	R:R:L84	R:R:Y327	58.1079	3.52	No	Yes	0	8	9
40	R:R:L84	R:R:N328	56.5615	10.98	No	No	0	8	7
41	R:R:F334	R:R:N328	23.0818	9.67	Yes	No	3	8	7
42	R:R:F334	R:R:V69	19.8347	9.18	Yes	No	0	8	8
43	R:R:L65	R:R:V69	10.9358	2.98	No	No	0	7	8
44	R:R:N328	R:R:V66	31.9332	13.3	No	Yes	3	7	9
45	R:R:V129	R:R:V94	15.0886	4.81	No	No	0	8	7
46	R:R:L93	R:R:V129	12.5929	5.96	No	No	0	7	8
47	R:R:L93	R:R:V89	10.0894	2.98	No	No	0	7	6
48	R:R:I70	R:R:V66	29.8489	3.07	No	Yes	3	7	9
49	R:R:I70	R:R:M76	17.5961	8.75	No	Yes	3	7	7
50	R:R:I70	R:R:N81	10.5561	4.25	No	No	3	7	8
51	R:R:P79	R:R:R333	14.1829	5.76	No	No	0	6	6
52	R:R:P79	R:R:T78	10.651	5.25	No	No	0	6	8
53	R:R:F277	R:R:I232	52.377	7.54	Yes	No	0	9	8
54	R:R:I232	R:R:S141	50.265	7.74	No	No	0	8	9
55	R:R:L235	R:R:S141	34.239	4.5	Yes	No	0	8	9
56	R:R:L235	R:R:Y145	28.7217	15.24	Yes	Yes	0	8	8
57	R:R:L149	R:R:Y145	53.6268	14.07	No	Yes	0	7	8
58	R:R:H150	R:R:L149	48.2004	2.57	No	No	0	6	7
59	R:R:H150	R:R:R153	44.5143	6.77	No	No	0	6	4
60	R:R:Q157	R:R:R153	42.6594	2.34	No	No	0	3	4
61	R:R:Q157	R:R:R162	38.9218	17.52	No	Yes	0	3	4
62	R:R:E143	R:R:R162	17.6357	4.65	No	Yes	0	8	4
63	R:R:E143	R:R:Y83	11.8257	15.71	No	Yes	5	8	7
64	R:R:I166	R:R:R162	13.7874	7.52	No	Yes	0	5	4
65	R:R:I166	R:R:Y83	11.8494	7.25	No	Yes	0	5	7
66	R:R:A163	R:R:Y83	15.848	4	No	Yes	0	7	7
67	R:R:A163	R:R:Y82	11.8969	2.67	No	No	0	7	5
68	R:R:D91	R:R:S133	26.6097	5.89	Yes	No	0	9	9
69	R:R:S133	R:R:S90	23.3824	6.52	No	No	0	9	8
70	R:R:S90	R:R:W171	20.4517	3.71	No	Yes	0	8	9
71	R:R:E105	R:R:K122	42.2085	5.4	No	No	0	4	5
72	R:R:R108	R:R:W107	11.9443	11	No	No	0	4	4
73	R:R:F112	R:R:K122	38.6015	2.48	No	No	0	8	5
74	R:R:C204	R:R:F112	27.3374	8.38	No	No	0	9	8
75	R:R:C119	R:R:C204	25.4311	5.46	No	No	0	9	9
76	R:R:C119	R:R:I187	15.7807	3.27	No	No	0	9	6
77	R:R:E127	R:R:N181	12.0946	14.46	No	No	0	4	4
78	R:R:F284	R:R:H285	14.875	9.05	Yes	No	0	6	7
79	R:R:H285	R:R:Y225	12.0392	6.53	No	Yes	0	7	8
80	R:R:L226	R:R:Y225	15.0728	3.52	No	Yes	0	4	8
81	R:R:F222	R:R:L226	13.7004	2.44	No	No	0	4	4
82	R:R:F222	R:R:L223	12.4427	6.09	No	Yes	0	4	4
83	R:R:R144	R:R:Y327	26.1074	4.12	Yes	Yes	2	9	9
84	R:R:S141	R:R:Y236	21.1319	13.99	No	Yes	0	9	9
85	R:R:L273	R:R:Y327	24.7706	8.21	Yes	Yes	2	8	9
86	R:R:M239	R:R:Y236	32.0677	4.79	Yes	Yes	2	9	9
87	R:R:I184	R:R:Y213	16.0615	4.84	No	Yes	4	5	2
88	R:R:I184	R:R:K208	13.5026	5.82	No	No	0	5	4
89	R:R:F277	R:R:M229	13.8111	4.98	Yes	No	0	9	7
90	R:R:M229	R:R:Y225	11.9048	4.79	No	Yes	0	7	8
91	R:R:L270	R:R:Y236	27.3454	5.86	Yes	Yes	2	8	9
92	R:R:L270	R:R:V266	23.6909	2.98	Yes	No	0	8	7
93	R:R:C262	R:R:V266	19.8505	1.71	No	No	0	5	7
94	R:R:C262	R:R:I258	17.8927	1.64	No	No	0	5	4
95	R:R:I258	R:R:N257	15.9271	1.42	No	No	0	4	3
96	R:R:N257	R:R:Q259	13.9535	15.85	No	No	0	3	3
97	R:R:K247	R:R:Q259	11.968	4.07	No	No	0	4	3
98	R:R:K247	R:R:S248	10.0538	1.53	No	No	0	4	4
99	R:R:I326	R:R:Y327	12.8658	6.04	Yes	Yes	2	8	9
100	R:R:D287	R:R:S312	13.5619	2.94	Yes	No	0	5	7
101	R:R:P283	R:R:S312	11.6477	3.56	No	No	0	9	7
102	L:L:R10	R:R:H309	47.7417	19.18	Yes	Yes	1	0	4
103	R:R:F316	R:R:Y317	24.3	11.35	Yes	Yes	1	8	7
104	R:R:D91	R:R:N63	13.558	6.73	Yes	No	0	9	9
105	R:R:F284	R:R:F316	10.4888	13.93	Yes	Yes	1	6	8
106	R:R:L87	R:R:Y327	23.3824	5.86	No	Yes	2	9	9
107	R:R:N323	R:R:Y327	23.3824	5.81	No	Yes	2	9	9
108	R:R:R144	R:R:Y236	23.8728	9.26	Yes	Yes	2	9	9
109	R:R:L273	R:R:Y236	25.9215	4.69	Yes	Yes	2	8	9
110	R:R:M239	R:R:Y145	30.7032	3.59	Yes	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F4	R:R:E299	5.83	1	Yes	No	0	1	0	1
L:L:F4	R:R:A302	5.55	1	Yes	No	0	1	0	1
L:L:F5	R:R:N109	7.25	0	No	No	0	2	0	1
L:L:L6	R:R:W297	20.5	1	No	Yes	0	1	0	1
L:L:F7	R:R:F44	6.43	1	Yes	Yes	0	1	0	1
L:L:F7	R:R:N306	9.67	1	Yes	No	0	4	0	1
L:L:F7	R:R:H309	18.1	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:E105	12.79	0	No	No	0	4	0	1
L:L:R8	R:R:N109	13.26	0	No	No	0	2	0	1
L:L:R8	R:R:T203	10.35	0	No	No	0	4	0	1
L:L:P9	R:R:F291	20.23	0	No	No	0	4	0	1
L:L:R10	R:R:E102	11.63	1	Yes	Yes	0	6	0	1
L:L:R10	R:R:F284	4.28	1	Yes	Yes	0	6	0	1
L:L:R10	R:R:D287	5.96	1	Yes	Yes	0	5	0	1
L:L:R10	R:R:H309	19.18	1	Yes	Yes	0	4	0	1
L:L:R10	R:R:G313	6	1	Yes	No	0	5	0	1
L:L:R10	R:R:F316	4.28	1	Yes	Yes	0	8	0	1
L:L:R10	R:R:Y317	4.12	1	Yes	Yes	0	7	0	1
L:L:N11	R:R:N181	4.09	0	Yes	No	0	4	0	1
L:L:N11	R:R:H185	8.93	0	Yes	No	0	5	0	1
L:L:N11	R:R:Y213	5.81	0	Yes	Yes	0	2	0	1
L:L:N11	R:R:R288	9.64	0	Yes	No	0	5	0	1
R:R:F44	R:R:H43	15.84	1	Yes	No	1	5	1	2
R:R:F44	R:R:V48	3.93	1	Yes	Yes	1	6	1	2
R:R:F44	R:R:N306	3.62	1	Yes	No	1	4	1	1
R:R:F44	R:R:L307	3.65	1	Yes	No	1	1	1	2
R:R:F44	R:R:V310	9.18	1	Yes	No	1	4	1	2
R:R:V48	R:R:Y52	8.83	1	Yes	Yes	6	7	2	2
R:R:V310	R:R:V48	4.81	1	No	Yes	4	6	2	2
R:R:M99	R:R:Y52	10.78	1	Yes	Yes	7	7	2	2
R:R:E102	R:R:Y52	8.98	1	Yes	Yes	6	7	1	2
R:R:Y317	R:R:Y52	6.95	1	Yes	Yes	7	7	1	2
R:R:G98	R:R:Y317	4.35	0	No	Yes	6	7	2	1
R:R:M99	R:R:Y317	14.37	1	Yes	Yes	7	7	2	1
R:R:E102	R:R:H309	3.69	1	Yes	Yes	6	4	1	1
R:R:E102	R:R:Y317	11.22	1	Yes	Yes	6	7	1	1
R:R:E105	R:R:K122	5.4	0	No	No	4	5	1	2
R:R:H185	R:R:T123	9.58	0	No	No	5	5	1	2
R:R:E127	R:R:N181	14.46	0	No	No	4	4	2	1
R:R:I216	R:R:N181	4.25	0	No	No	5	4	2	1
R:R:I184	R:R:V206	7.68	4	No	No	5	4	2	2
R:R:I184	R:R:Y213	4.84	4	No	Yes	5	2	2	1
R:R:H185	R:R:V206	4.15	0	No	No	5	4	1	2
R:R:V206	R:R:Y213	16.4	4	No	Yes	4	2	2	1
R:R:M210	R:R:Y213	8.38	0	No	Yes	3	2	2	1
R:R:I217	R:R:Y213	13.3	0	Yes	Yes	5	2	2	1
R:R:I217	R:R:R288	11.27	0	Yes	No	5	5	2	1
R:R:F284	R:R:W281	6.01	1	Yes	Yes	6	8	1	2
R:R:F316	R:R:W281	7.02	1	Yes	Yes	8	8	1	2
R:R:F284	R:R:H285	9.05	1	Yes	No	6	7	1	2
R:R:F284	R:R:R288	11.76	1	Yes	No	6	5	1	1
R:R:F284	R:R:F316	13.93	1	Yes	Yes	6	8	1	1
R:R:D287	R:R:F305	7.17	1	Yes	Yes	5	5	1	2
R:R:D287	R:R:H309	15.13	1	Yes	Yes	5	4	1	1
R:R:F291	R:R:W297	5.01	1	No	Yes	4	1	1	1
R:R:F291	R:R:F305	9.65	1	No	Yes	4	5	1	2
R:R:V294	R:R:W297	22.07	0	No	Yes	3	1	2	1
R:R:F305	R:R:W297	11.02	1	Yes	Yes	5	1	2	1
R:R:F316	R:R:Y317	11.35	1	Yes	Yes	8	7	1	1
R:R:D287	R:R:S312	2.94	1	Yes	No	5	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W57_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	287
Number of Links	322
Number of Hubs	43
Number of Links mediated by Hubs	152
Number of Communities	8
Number of Nodes involved in Communities	53
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	72212
Length Of Smallest Path	3
Average Path Length	13.7962
Length of Longest Path	33
Minimum Path Strength	1.03
Average Path Strength	7.28739
Maximum Path Strength	21.285
Minimum Path Correlation	0.7
Average Path Correlation	0.943508
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	57.4258
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5733
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • neuropeptide signaling pathway • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • neuromedin U receptor activity • neuromedin U binding • neuropeptide binding • peptide binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • monoatomic anion transmembrane transporter activity • chloride transmembrane transporter activity • gated channel activity • monoatomic ion channel activity • intracellularly calcium-gated channel activity • intracellularly calcium-gated chloride channel activity • ligand-gated monoatomic anion channel activity • ligand-gated channel activity • ligand-gated monoatomic ion channel activity • passive transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • monoatomic anion channel activity • transporter activity • transmembrane transporter activity • chloride channel activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • response to stress • multicellular organismal response to stress • response to pain • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • reduction of food intake in response to dietary excess • response to nutrient levels • homeostatic process • eating behavior • feeding behavior • behavior • multicellular organismal-level homeostasis • response to dietary excess • energy homeostasis • central nervous system development • nervous system development • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of multicellular organismal process • grooming behavior • periplasmic space
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ4
Sequence	>7W57_nogp_Chain_R H F F L P V S V V Y V P I F V V G V I G N V L V C L V I L Q H Q A M K T P T N Y Y L F S L A V S D L L V L L L G M P L E V Y E M W R N Y P F L F G P V G C Y F K T A L F E T V C F A S I L S I T T V S V E R Y V A I L H P F R A K L Q S T R R R A L R I L G I V W G F S V L F S L P N T S I H G I K F H Y F P G S A T C T V I K P M W I Y N F I I Q V T S F L F Y L L P M T V I S V L Y Y L M A L R L K K D K S L E A D E G N A N I Q R P C R K S V N K M L F V L V L V F A I C W A P F H I D R L F F S F V E E W S E S L A A V F N L V H V V S G V F F Y L S S A V N P I I Y N L L S R R F Q A A F Q N V I S S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7W55	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W55 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-		2.8	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W57	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-S	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W57 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-S	-		3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7XK8	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-	Gi1/β1/γ2	3.3	2023-02-22	doi.org/10.1038/s41467-022-34814-4
	7XK8 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-		3.3	2023-02-22	doi.org/10.1038/s41467-022-34814-4

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