Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:F11 10.266520
2L:L:F21 6.126500
3L:L:R24 4.72400
4L:L:N25 6.465400
5L:L:?26 6.7425450
6R:R:F44 4.7275401
7R:R:Y52 8.296517
8R:R:F56 8.6025416
9R:R:K77 14.6725437
10R:R:Y83 4.198507
11R:R:F85 6.502535
12R:R:M106 6.446505
13R:R:P111 2.65574
14R:R:F126 3.04406
15R:R:E127 6.575454
16R:R:F131 10.814586
17R:R:R144 6.14409
18R:R:Y145 6.362508
19R:R:H190 10.03621
20R:R:F192 5.472523
21R:R:L235 5.6725408
22R:R:Y236 7.408599
23R:R:N267 7.994106
24R:R:F277 6.7409
25R:R:W281 6.7175408
26R:R:D287 4.7375445
27R:R:R288 6.9075405
28R:R:F305 8.13445
29R:R:Y317 12.07517
30R:R:I326 2.248508
31R:R:Y327 4.0175409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:E6 L:L:Q8 13.47698.92NoNo000
2L:L:F11 R:R:S201 11.9893.96YesNo202
3R:R:H190 R:R:S201 17.546411.16YesNo212
4L:L:A12 R:R:S201 30.47651.71NoNo002
5L:L:A12 R:R:T203 31.41021.68NoNo004
6R:R:T203 R:R:T205 32.40344.71NoNo044
7R:R:T205 R:R:V206 36.24224.76NoNo044
8R:R:V206 R:R:Y213 37.183321.45NoNo042
9L:L:N25 R:R:Y213 41.77735.81YesNo002
10L:L:N25 L:L:P23 23.85158.15YesNo000
11L:L:P23 R:R:F291 23.24898.67NoNo004
12R:R:D287 R:R:F291 13.08267.17YesNo454
13R:R:D287 R:R:H309 13.12733.78YesNo054
14L:L:F21 R:R:H309 13.6485.66YesNo004
15L:L:F21 R:R:E105 20.35863.5YesNo004
16L:L:F21 R:R:M106 27.6426.22YesYes005
17L:L:R22 R:R:E105 18.074616.28NoNo004
18L:L:?26 L:L:N25 51.84326.8YesYes000
19L:L:?26 R:R:E127 53.353413.12YesYes504
20R:R:E127 R:R:R288 70.54643.49YesYes045
21R:R:F284 R:R:R288 58.63196.41NoYes065
22L:L:R24 R:R:F284 58.0594.28YesNo006
23L:L:R24 R:R:E102 49.93495.82YesNo006
24L:L:R24 R:R:F126 14.19114.28YesYes006
25R:R:M106 R:R:V48 11.62827.61YesNo056
26R:R:F44 R:R:V48 13.48442.62YesNo016
27R:R:E102 R:R:Y52 22.72074.49NoYes067
28R:R:Y317 R:R:Y52 16.021321.84YesYes177
29R:R:R288 R:R:S221 1003.95YesNo055
30R:R:H285 R:R:S221 99.869812.55NoNo075
31R:R:H285 R:R:Y225 99.732210.89NoNo078
32R:R:M229 R:R:Y225 99.43463.59NoNo078
33R:R:F277 R:R:M229 99.10724.98YesNo097
34R:R:F277 R:R:I137 44.59325.02YesNo098
35R:R:I137 R:R:Y327 43.00864.84NoYes089
36R:R:I326 R:R:Y327 15.33312.42YesYes089
37R:R:R144 R:R:Y327 34.10714.12YesYes099
38R:R:E143 R:R:R144 42.74086.98NoYes089
39R:R:E143 R:R:T80 41.11158.47NoNo088
40R:R:T78 R:R:T80 39.54174.71NoNo088
41R:R:N81 R:R:T78 36.25345.85NoNo088
42R:R:I70 R:R:N81 15.59724.25NoNo378
43R:R:F85 R:R:I70 13.893512.56YesNo357
44R:R:F277 R:R:I232 54.00813.77YesNo098
45R:R:I232 R:R:Y236 52.81034.84NoYes989
46R:R:R144 R:R:Y236 36.03398.23YesYes099
47R:R:K77 R:R:N81 18.99716.99YesNo378
48R:R:F85 R:R:K77 13.95313.72YesYes357
49R:R:C67 R:R:F85 13.98285.59NoYes075
50R:R:C67 R:R:L71 10.49734.76NoNo073
51R:R:R144 R:R:V140 22.70215.23YesNo099
52R:R:V140 R:R:Y83 21.02823.79NoYes097
53R:R:I166 R:R:Y83 12.40194.84NoYes057
54R:R:E127 R:R:S178 28.35995.75YesNo047
55R:R:S178 R:R:T128 27.31474.8NoNo075
56R:R:S174 R:R:T128 23.05924.8NoNo085
57L:L:R22 R:R:P111 16.92152.88NoYes004
58R:R:F131 R:R:S174 18.68479.25YesNo068
59R:R:F131 R:R:F224 11.825318.22YesNo865
60R:R:F224 R:R:I134 10.74285.02NoNo058
61R:R:M239 R:R:Y236 29.4355.99NoYes099
62R:R:M239 R:R:Y145 17.51293.59NoYes098
63R:R:I148 R:R:M239 12.55817.29NoNo089
64R:R:I148 R:R:L243 11.57242.85NoNo088
65R:R:L243 R:R:R263 10.56066.07NoNo087
66R:R:E102 R:R:M106 32.055.41NoYes065
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:E5 R:R:P199 7.86 0 No No 0 3 0 1
L:L:E6 R:R:H190 4.92 2 No Yes 0 1 0 1
L:L:F11 R:R:H190 6.79 2 Yes Yes 0 1 0 1
L:L:F11 R:R:S201 3.96 2 Yes No 0 2 0 1
L:L:Q14 R:R:H43 6.18 0 No No 0 5 0 1
L:L:Y18 R:R:W297 3.86 0 No No 0 1 0 1
L:L:F19 R:R:W297 9.02 0 No No 0 1 0 1
L:L:F19 R:R:F305 6.43 0 No Yes 0 5 0 1
L:L:L20 R:R:H43 6.43 0 No No 0 5 0 1
L:L:F21 R:R:H43 6.79 0 Yes No 0 5 0 1
L:L:F21 R:R:E105 3.5 0 Yes No 0 4 0 1
L:L:F21 R:R:M106 6.22 0 Yes Yes 0 5 0 1
L:L:F21 R:R:N306 8.46 0 Yes No 0 4 0 1
L:L:F21 R:R:H309 5.66 0 Yes No 0 4 0 1
L:L:R22 R:R:E105 16.28 0 No No 0 4 0 1
L:L:P23 R:R:F291 8.67 0 No No 0 4 0 1
L:L:R24 R:R:E102 5.82 0 Yes No 0 6 0 1
L:L:R24 R:R:F126 4.28 0 Yes Yes 0 6 0 1
L:L:R24 R:R:F284 4.28 0 Yes No 0 6 0 1
L:L:R24 R:R:G313 4.5 0 Yes No 0 5 0 1
L:L:N25 R:R:H185 5.1 0 Yes No 0 5 0 1
L:L:N25 R:R:Y213 5.81 0 Yes No 0 2 0 1
L:L:?26 R:R:T123 3.65 5 Yes No 0 5 0 1
L:L:?26 R:R:E127 13.12 5 Yes Yes 0 4 0 1
L:L:?26 R:R:N181 3.4 5 Yes No 0 4 0 1
R:R:F45 R:R:M106 9.95 0 No Yes 4 5 2 1
R:R:V48 R:R:Y52 5.05 0 No Yes 6 7 2 2
R:R:M106 R:R:V48 7.61 0 Yes No 5 6 1 2
R:R:E102 R:R:Y52 4.49 0 No Yes 6 7 1 2
R:R:F126 R:R:V94 3.93 0 Yes No 6 7 1 2
R:R:E102 R:R:M106 5.41 0 No Yes 6 5 1 1
R:R:M106 R:R:V103 3.04 0 Yes No 5 6 1 2
R:R:E105 R:R:N109 11.83 0 No No 4 2 1 2
R:R:C119 R:R:P111 3.77 7 No Yes 9 4 2 1
R:R:C204 R:R:P111 3.77 7 No Yes 9 4 2 1
R:R:C119 R:R:C204 7.28 7 No No 9 9 2 2
R:R:T123 R:R:T182 4.71 0 No No 5 5 1 2
R:R:E127 R:R:S178 5.75 5 Yes No 4 7 1 2
R:R:E127 R:R:N181 3.94 5 Yes No 4 4 1 1
R:R:E127 R:R:R288 3.49 5 Yes Yes 4 5 1 2
R:R:F192 R:R:H190 14.71 2 Yes Yes 3 1 2 1
R:R:H190 R:R:P199 19.83 2 Yes No 1 3 1 1
R:R:H190 R:R:S201 11.16 2 Yes No 1 2 1 1
R:R:F192 R:R:P199 5.78 2 Yes No 3 3 2 1
R:R:T203 R:R:T205 4.71 0 No No 4 4 1 2
R:R:T205 R:R:V206 4.76 0 No No 4 4 2 2
R:R:V206 R:R:Y213 21.45 0 No No 4 2 2 1
R:R:F284 R:R:R288 6.41 0 No Yes 6 5 1 2
R:R:D287 R:R:F291 7.17 4 Yes No 5 4 2 1
R:R:D287 R:R:F305 3.58 4 Yes Yes 5 5 2 1
R:R:D287 R:R:H309 3.78 4 Yes No 5 4 2 1
R:R:F290 R:R:F305 10.72 0 No Yes 4 5 2 1
R:R:F291 R:R:F305 11.79 4 No Yes 4 5 1 1
R:R:E295 R:R:W297 4.36 0 No No 3 1 2 1
L:L:R22 R:R:P111 2.88 0 No Yes 0 4 0 1
R:R:I216 R:R:N181 2.83 0 No No 5 4 2 1
L:L:F19 R:R:A302 2.77 0 No No 0 1 0 1
R:R:H190 R:R:V198 2.77 2 Yes No 1 4 1 2
R:R:F126 R:R:L97 2.44 0 Yes No 6 5 1 2
R:R:I184 R:R:Y213 2.42 0 No No 5 2 2 1
R:R:H185 R:R:Y120 2.18 0 No No 5 6 1 2
L:L:A12 R:R:S201 1.71 0 No No 0 2 0 1
L:L:A12 R:R:T203 1.68 0 No No 0 4 0 1
R:R:F126 R:R:G98 1.51 0 Yes No 6 6 1 2
R:R:F114 R:R:P111 1.44 0 No Yes 7 4 2 1
R:R:P111 R:R:Y110 1.39 7 Yes No 4 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7XK8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.04
Number of Linked Nodes 282
Number of Links 295
Number of Hubs 31
Number of Links mediated by Hubs 123
Number of Communities 10
Number of Nodes involved in Communities 38
Number of Links involved in Communities 43
Path Summary
Number Of Nodes in MetaPath 67
Number Of Links MetaPath 66
Number of Shortest Paths 49031
Length Of Smallest Path 3
Average Path Length 16.1648
Length of Longest Path 34
Minimum Path Strength 1.375
Average Path Strength 6.33234
Maximum Path Strength 23.99
Minimum Path Correlation 0.7
Average Path Correlation 0.934387
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 49.5356
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.5947
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • multicellular organismal process   • system process   • positive regulation of smooth muscle contraction   • regulation of system process   • positive regulation of biological process   • muscle contraction   • muscle system process   • regulation of muscle system process   • smooth muscle contraction   • regulation of muscle contraction   • regulation of smooth muscle contraction   • positive regulation of muscle contraction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • multicellular organismal-level homeostasis   • homeostatic process   • temperature homeostasis   • energy homeostasis   • regulation of behavior   • behavior   • feeding behavior   • regulation of feeding behavior   • regulation of grooming behavior   • grooming behavior   • positive regulation of cell communication   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • positive regulation of synaptic transmission   • cell-cell signaling   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • positive regulation of cellular process   • positive regulation of signaling   • cellular anatomical structure   • extracellular region   • axon   • synapse   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • presynapse   • cell projection   • distal axon   • terminal bouton   • cell junction   • neuron projection terminus   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • neuropeptide receptor activity   • neuromedin U receptor activity   • binding   • neuromedin U binding   • neuropeptide binding   • peptide binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • monoatomic anion transmembrane transporter activity   • chloride transmembrane transporter activity   • gated channel activity   • monoatomic ion channel activity   • intracellularly calcium-gated channel activity   • intracellularly calcium-gated chloride channel activity   • ligand-gated monoatomic anion channel activity   • ligand-gated channel activity   • ligand-gated monoatomic ion channel activity   • passive transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • monoatomic ion transmembrane transporter activity   • monoatomic anion channel activity   • transporter activity   • transmembrane transporter activity   • inorganic anion transmembrane transporter activity   • chloride channel activity   • response to stress   • multicellular organismal response to stress   • response to pain   • organic anion transport   • carboxylic acid transport   • secretion   • transport   • arachidonate transport   • lipid localization   • lipid transport   • establishment of localization   • organic acid transport   • localization   • arachidonate secretion   • monocarboxylic acid transport   • fatty acid transport   • icosanoid transport   • macromolecule localization   • icosanoid secretion   • long-chain fatty acid transport   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • positive regulation of intracellular signal transduction   • regulation of response to stimulus   • calcium-mediated signaling   • reduction of food intake in response to dietary excess   • response to nutrient levels   • eating behavior   • response to dietary excess   • developmental process   • multicellular organism development   • central nervous system development   • anatomical structure development   • nervous system development   • system development   • phospholipase C-activating G protein-coupled receptor signaling pathway   • membrane   • cell periphery   • plasma membrane   • D2 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNH2
PDB ResiduesL:L:?26
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9GZQ4
Sequence
>7XK8_nogp_Chain_R
SHFFLPVSV VYVPIFVVG VIGNVLVCL VILQHQAMK TPTNYYLFS 
LAVSDLLVL LLGMPLEVY EMWRNYPFL FGPVGCYFK TALFETVCF 
ASILSITTV SVERYVAIL HPFRAKLQS TRRRALRIL GIVWGFSVL 
FSLPNTSIH GIKFHYFPN GSLVPGSAT CTVIKPMWI YNFIIQVTS 
FLFYLLPMT VISVLYYLM ALRLKKDKI QRPCRKSVN KMLFVLVLV 
FAICWAPFH IDRLFFSFV EEWSESLAA VFNLVHVVS GVFFYLSSA 
VNPIIYNLL SRR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK8APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-U-25-Gi1/β1/γ23.32023-02-2210.1038/s41467-022-34814-4
7XK8 (No Gprot) APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-U-25-3.32023-02-2210.1038/s41467-022-34814-4
7W57APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ23.22022-04-2010.1038/s41467-022-29683-w
7W57 (No Gprot) APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-S-3.22022-04-2010.1038/s41467-022-29683-w
7W55APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ22.82022-04-2010.1038/s41467-022-29683-w
7W55 (No Gprot) APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-U-25-2.82022-04-2010.1038/s41467-022-29683-w




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Download 7XK8_nogp.zip



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