psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F1	L:L:F7	4.29	No	No	0	0	0
2	L:L:F7	L:L:R2	12.83	No	No	0	0	0
3	L:L:Q8	L:L:R2	5.84	No	No	0	0	0
4	L:L:E5	L:L:F11	7	No	Yes	0	0	0
5	L:L:E5	R:R:P199	7.86	No	No	0	0	3
6	L:L:E6	L:L:Q8	8.92	No	No	0	0	0
7	L:L:E6	L:L:F11	25.65	No	Yes	2	0	0
8	L:L:E6	R:R:H190	4.92	No	Yes	2	0	1
9	L:L:P10	L:L:S9	5.34	No	No	0	0	0
10	L:L:F11	L:L:S13	7.93	Yes	No	0	0	0
11	L:L:F11	R:R:H190	6.79	Yes	Yes	2	0	1
12	L:L:F11	R:R:S201	3.96	Yes	No	2	0	2
13	L:L:Q14	R:R:H43	6.18	No	No	0	0	5
14	L:L:R16	L:L:Y18	13.38	No	No	0	0	0
15	L:L:Y18	R:R:W297	3.86	No	No	0	0	1
16	L:L:F19	R:R:W297	9.02	No	No	0	0	1
17	L:L:F19	R:R:F305	6.43	No	Yes	0	0	5
18	L:L:L20	R:R:H43	6.43	No	No	0	0	5
19	L:L:F21	R:R:H43	6.79	Yes	No	0	0	5
20	L:L:F21	R:R:E105	3.5	Yes	No	0	0	4
21	L:L:F21	R:R:M106	6.22	Yes	Yes	0	0	5
22	L:L:F21	R:R:N306	8.46	Yes	No	0	0	4
23	L:L:F21	R:R:H309	5.66	Yes	No	0	0	4
24	L:L:R22	R:R:E105	16.28	No	No	0	0	4
25	L:L:N25	L:L:P23	8.15	Yes	No	0	0	0
26	L:L:P23	R:R:F291	8.67	No	No	0	0	4
27	L:L:R24	R:R:E102	5.82	Yes	No	0	0	6
28	L:L:R24	R:R:F126	4.28	Yes	Yes	0	0	6
29	L:L:R24	R:R:F284	4.28	Yes	No	0	0	6
30	L:L:R24	R:R:G313	4.5	Yes	No	0	0	5
31	L:L:?26	L:L:N25	6.8	Yes	Yes	0	0	0
32	L:L:N25	R:R:H185	5.1	Yes	No	0	0	5
33	L:L:N25	R:R:Y213	5.81	Yes	No	0	0	2
34	L:L:?26	R:R:T123	3.65	Yes	No	0	0	5
35	L:L:?26	R:R:E127	13.12	Yes	Yes	5	0	4
36	L:L:?26	R:R:N181	3.4	Yes	No	5	0	4
37	R:R:F44	R:R:P47	5.78	Yes	No	0	1	4
38	R:R:F44	R:R:V310	7.87	Yes	No	0	1	4
39	R:R:F45	R:R:M106	9.95	No	Yes	0	4	5
40	R:R:L46	R:R:P47	3.28	No	No	0	2	4
41	R:R:V48	R:R:Y52	5.05	No	Yes	0	6	7
42	R:R:M106	R:R:V48	7.61	Yes	No	0	5	6
43	R:R:V51	R:R:Y52	3.79	No	Yes	1	5	7
44	R:R:V314	R:R:V51	3.21	No	No	1	5	5
45	R:R:E102	R:R:Y52	4.49	No	Yes	0	6	7
46	R:R:V314	R:R:Y52	6.31	No	Yes	1	5	7
47	R:R:Y317	R:R:Y52	21.84	Yes	Yes	1	7	7
48	R:R:P54	R:R:V53	3.53	No	No	0	4	5
49	R:R:I55	R:R:Y317	15.71	No	Yes	0	7	7
50	R:R:F56	R:R:L95	13.4	Yes	No	1	6	7
51	R:R:F56	R:R:L96	4.87	Yes	No	0	6	5
52	R:R:F56	R:R:M99	9.95	Yes	No	1	6	7
53	R:R:F56	R:R:Y317	6.19	Yes	Yes	1	6	7
54	R:R:G62	R:R:I61	3.53	No	No	6	8	5
55	R:R:I61	R:R:L65	4.28	No	No	6	5	7
56	R:R:G62	R:R:L65	5.13	No	No	6	8	7
57	R:R:L92	R:R:N63	12.36	No	No	0	7	9
58	R:R:A88	R:R:V66	5.09	No	No	0	9	9
59	R:R:C67	R:R:L71	4.76	No	No	0	7	3
60	R:R:C67	R:R:F85	5.59	No	Yes	0	7	5
61	R:R:I70	R:R:K77	14.54	No	Yes	3	7	7
62	R:R:I70	R:R:N81	4.25	No	No	3	7	8
63	R:R:F85	R:R:I70	12.56	Yes	No	3	5	7
64	R:R:H73	R:R:M76	9.19	No	No	0	5	7
65	R:R:K77	R:R:N81	6.99	Yes	No	3	7	8
66	R:R:K77	R:R:Y82	33.44	Yes	No	0	7	5
67	R:R:F85	R:R:K77	3.72	Yes	Yes	3	5	7
68	R:R:P79	R:R:T78	5.25	No	No	0	6	8
69	R:R:T78	R:R:T80	4.71	No	No	0	8	8
70	R:R:N81	R:R:T78	5.85	No	No	0	8	8
71	R:R:E143	R:R:T80	8.47	No	No	0	8	8
72	R:R:R160	R:R:Y82	9.26	No	No	0	2	5
73	R:R:V140	R:R:Y83	3.79	No	Yes	0	9	7
74	R:R:A163	R:R:Y83	4	No	Yes	0	7	7
75	R:R:I166	R:R:Y83	4.84	No	Yes	0	5	7
76	R:R:L167	R:R:Y83	5.86	No	Yes	0	7	7
77	R:R:L84	R:R:Y327	4.69	No	Yes	0	8	9
78	R:R:L84	R:R:N328	4.12	No	No	0	8	7
79	R:R:F85	R:R:V89	7.87	Yes	No	0	5	6
80	R:R:S86	R:R:W171	3.71	No	No	0	9	9
81	R:R:L87	R:R:S136	6.01	No	No	0	9	8
82	R:R:I137	R:R:L87	7.14	No	No	0	8	9
83	R:R:S90	R:R:V129	3.23	No	No	0	8	8
84	R:R:S133	R:R:S90	6.52	No	No	0	9	8
85	R:R:D91	R:R:S320	10.31	No	No	0	9	8
86	R:R:D91	R:R:P324	11.27	No	No	0	9	9
87	R:R:L92	R:R:L96	8.3	No	No	0	7	5
88	R:R:L93	R:R:V129	4.47	No	No	0	7	8
89	R:R:F126	R:R:V94	3.93	Yes	No	0	6	7
90	R:R:V129	R:R:V94	3.21	No	No	0	8	7
91	R:R:S320	R:R:V94	3.23	No	No	0	8	7
92	R:R:L95	R:R:Y317	7.03	No	Yes	1	7	7
93	R:R:L125	R:R:L97	6.92	No	No	0	4	5
94	R:R:M99	R:R:P100	5.03	No	No	0	7	8
95	R:R:M99	R:R:Y317	9.58	No	Yes	1	7	7
96	R:R:E102	R:R:M106	5.41	No	Yes	0	6	5
97	R:R:M106	R:R:V103	3.04	Yes	No	0	5	6
98	R:R:E105	R:R:N109	11.83	No	No	0	4	2
99	R:R:R108	R:R:W107	12	No	No	0	4	4
100	R:R:R108	R:R:Y110	15.43	No	No	0	4	4
101	R:R:F112	R:R:R108	7.48	No	No	0	8	4
102	R:R:C119	R:R:P111	3.77	No	Yes	7	9	4
103	R:R:C204	R:R:P111	3.77	No	Yes	7	9	4
104	R:R:F114	R:R:K122	3.72	No	No	0	7	5
105	R:R:G115	R:R:P116	4.06	No	No	0	7	3
106	R:R:P116	R:R:Y120	4.17	No	No	0	3	6
107	R:R:C119	R:R:C204	7.28	No	No	7	9	9
108	R:R:T123	R:R:T182	4.71	No	No	0	5	5
109	R:R:A124	R:R:T182	5.03	No	No	0	7	5
110	R:R:E127	R:R:S178	5.75	Yes	No	0	4	7
111	R:R:E127	R:R:N181	3.94	Yes	No	5	4	4
112	R:R:E127	R:R:R288	3.49	Yes	Yes	0	4	5
113	R:R:S174	R:R:T128	4.8	No	No	0	8	5
114	R:R:T128	R:R:V175	4.76	No	No	0	5	4
115	R:R:S178	R:R:T128	4.8	No	No	0	7	5
116	R:R:F131	R:R:L135	7.31	Yes	No	0	6	5
117	R:R:F131	R:R:F173	4.29	Yes	No	0	6	4
118	R:R:F131	R:R:S174	9.25	Yes	No	0	6	8
119	R:R:F131	R:R:F177	15	Yes	No	8	6	4
120	R:R:F131	R:R:F224	18.22	Yes	No	8	6	5
121	R:R:A132	R:R:S174	3.42	No	No	0	7	8
122	R:R:F224	R:R:I134	5.02	No	No	0	5	8
123	R:R:L135	R:R:V170	4.47	No	No	0	5	7
124	R:R:F277	R:R:I137	5.02	Yes	No	0	9	8
125	R:R:I137	R:R:Y327	4.84	No	Yes	0	8	9
126	R:R:P228	R:R:T138	3.5	No	No	0	9	7
127	R:R:R144	R:R:V140	5.23	Yes	No	0	9	9
128	R:R:I232	R:R:S141	7.74	No	No	9	8	9
129	R:R:S141	R:R:Y236	5.09	No	Yes	9	9	9
130	R:R:E143	R:R:R144	6.98	No	Yes	0	8	9
131	R:R:R144	R:R:Y236	8.23	Yes	Yes	0	9	9
132	R:R:R144	R:R:Y327	4.12	Yes	Yes	0	9	9
133	R:R:L149	R:R:Y145	4.69	No	Yes	0	7	8
134	R:R:L235	R:R:Y145	15.24	Yes	Yes	0	8	8
135	R:R:L238	R:R:Y145	7.03	No	Yes	0	4	8
136	R:R:M239	R:R:Y145	3.59	No	Yes	0	9	8
137	R:R:I148	R:R:M239	7.29	No	No	0	8	9
138	R:R:H150	R:R:L149	10.29	No	No	0	6	7
139	R:R:L149	R:R:R242	6.07	No	No	0	7	5
140	R:R:H150	R:R:R153	14.67	No	No	0	6	4
141	R:R:R162	R:R:T159	5.17	No	No	0	4	7
142	R:R:I166	R:R:R165	7.52	No	No	0	5	2
143	R:R:I169	R:R:R165	17.54	No	No	0	4	2
144	R:R:F177	R:R:T220	5.19	No	No	0	4	4
145	R:R:F177	R:R:F224	6.43	No	No	8	4	5
146	R:R:I184	R:R:K208	11.63	No	No	0	5	4
147	R:R:G186	R:R:I207	3.53	No	No	0	4	3
148	R:R:K188	R:R:T205	7.51	No	No	0	1	4
149	R:R:I207	R:R:K188	13.09	No	No	0	3	1
150	R:R:F189	R:R:V198	6.55	No	No	0	1	4
151	R:R:F192	R:R:H190	14.71	Yes	Yes	2	3	1
152	R:R:H190	R:R:P199	19.83	Yes	No	2	1	3
153	R:R:H190	R:R:S201	11.16	Yes	No	2	1	2
154	R:R:F192	R:R:P199	5.78	Yes	No	2	3	3
155	R:R:T203	R:R:T205	4.71	No	No	0	4	4
156	R:R:T205	R:R:V206	4.76	No	No	0	4	4
157	R:R:V206	R:R:Y213	21.45	No	No	0	4	2
158	R:R:N214	R:R:S292	4.47	No	No	0	3	4
159	R:R:I217	R:R:R288	13.78	No	Yes	0	5	5
160	R:R:Q218	R:R:V219	4.3	No	No	0	4	3
161	R:R:F222	R:R:Q218	8.2	No	No	0	4	4
162	R:R:H285	R:R:S221	12.55	No	No	0	7	5
163	R:R:R288	R:R:S221	3.95	Yes	No	0	5	5
164	R:R:F222	R:R:L226	9.74	No	No	0	4	4
165	R:R:M229	R:R:Y225	3.59	No	No	0	7	8
166	R:R:H285	R:R:Y225	10.89	No	No	0	7	8
167	R:R:F277	R:R:M229	4.98	Yes	No	0	9	7
168	R:R:A278	R:R:M229	3.22	No	No	0	6	7
169	R:R:S233	R:R:T230	3.2	No	No	0	4	3
170	R:R:I232	R:R:Y236	4.84	No	Yes	9	8	9
171	R:R:F277	R:R:I232	3.77	Yes	No	0	9	8
172	R:R:M239	R:R:Y236	5.99	No	Yes	0	9	9
173	R:R:L270	R:R:Y236	12.89	No	Yes	0	8	9
174	R:R:A240	R:R:N267	4.69	No	Yes	0	5	6
175	R:R:L243	R:R:R263	6.07	No	No	0	8	7
176	R:R:K244	R:R:K247	7.18	No	No	0	4	4
177	R:R:K247	R:R:R263	9.9	No	No	0	4	7
178	R:R:K247	R:R:N267	6.99	No	Yes	0	4	6
179	R:R:P261	R:R:R260	7.21	No	No	0	3	3
180	R:R:K264	R:R:N267	6.99	No	Yes	10	6	6
181	R:R:K264	R:R:K268	5.75	No	No	0	6	6
182	R:R:F271	R:R:K264	4.96	No	No	10	5	6
183	R:R:F271	R:R:N267	13.29	No	Yes	10	5	6
184	R:R:L329	R:R:M269	5.65	No	No	0	6	8
185	R:R:I326	R:R:L273	4.28	Yes	No	0	8	8
186	R:R:F277	R:R:W281	13.03	Yes	Yes	0	9	8
187	R:R:C280	R:R:W281	5.22	No	Yes	0	8	8
188	R:R:C280	R:R:S319	6.89	No	No	0	8	9
189	R:R:F316	R:R:W281	6.01	No	Yes	0	8	8
190	R:R:P283	R:R:S312	3.56	No	No	0	9	7
191	R:R:F315	R:R:P283	7.22	No	No	0	7	9
192	R:R:F284	R:R:R288	6.41	No	Yes	0	6	5
193	R:R:D287	R:R:F291	7.17	Yes	No	4	5	4
194	R:R:D287	R:R:F305	3.58	Yes	Yes	4	5	5
195	R:R:D287	R:R:H309	3.78	Yes	No	0	5	4
196	R:R:D287	R:R:S312	4.42	Yes	No	0	5	7
197	R:R:L289	R:R:S292	4.5	No	No	0	6	4
198	R:R:F290	R:R:F305	10.72	No	Yes	0	4	5
199	R:R:F290	R:R:V308	11.8	No	No	0	4	4
200	R:R:F291	R:R:F305	11.79	No	Yes	4	4	5
201	R:R:E296	R:R:V294	4.28	No	No	0	2	3
202	R:R:E295	R:R:W297	4.36	No	No	0	3	1
203	R:R:E299	R:R:S298	4.31	No	No	0	1	1
204	R:R:L301	R:R:S298	9.01	No	No	0	1	1
205	R:R:F315	R:R:V311	5.24	No	No	0	7	5
206	R:R:F315	R:R:L318	4.87	No	No	0	7	5
207	R:R:N323	R:R:S319	4.47	No	No	0	9	9
208	R:R:R333	R:R:S331	10.54	No	No	0	6	8
209	R:R:F192	R:R:G195	3.01	Yes	No	0	3	2
210	R:R:L235	R:R:V142	2.98	Yes	No	0	8	6
211	R:R:L223	R:R:V219	2.98	No	No	0	4	3
212	R:R:L235	R:R:V231	2.98	Yes	No	0	8	7
213	R:R:N328	R:R:V69	2.96	No	No	0	7	8
214	R:R:I184	R:R:I212	2.94	No	No	0	5	2
215	L:L:R22	R:R:P111	2.88	No	Yes	0	0	4
216	R:R:E299	R:R:S300	2.87	No	No	0	1	1
217	R:R:I148	R:R:L243	2.85	No	No	0	8	8
218	R:R:I286	R:R:L289	2.85	No	No	0	5	6
219	R:R:I216	R:R:N181	2.83	No	No	0	5	4
220	R:R:I217	R:R:N214	2.83	No	No	0	5	3
221	R:R:L330	R:R:M269	2.83	No	No	0	7	8
222	L:L:F19	R:R:A302	2.77	No	No	0	0	1
223	R:R:A88	R:R:F85	2.77	No	Yes	0	9	5
224	R:R:H190	R:R:V198	2.77	Yes	No	0	1	4
225	R:R:A282	R:R:Y225	2.67	No	No	0	6	8
226	R:R:L68	R:R:Q72	2.66	No	No	0	4	4
227	R:R:L156	R:R:Q157	2.66	No	No	0	3	3
228	R:R:E296	R:R:L301	2.65	No	No	0	2	1
229	R:R:F44	R:R:S42	2.64	Yes	No	0	1	6
230	R:R:F45	R:R:S49	2.64	No	No	0	4	5
231	R:R:F44	R:R:V48	2.62	Yes	No	0	1	6
232	R:R:F121	R:R:V117	2.62	No	No	0	5	3
233	R:R:C130	R:R:W281	2.61	No	Yes	0	7	8
234	L:L:D4	L:L:E5	2.6	No	No	0	0	0
235	R:R:A132	R:R:W171	2.59	No	No	0	7	9
236	R:R:T139	R:R:Y83	2.5	No	Yes	0	8	7
237	R:R:F126	R:R:L97	2.44	Yes	No	0	6	5
238	R:R:I184	R:R:Y213	2.42	No	No	0	5	2
239	R:R:F192	R:R:N194	2.42	Yes	No	0	3	5
240	R:R:I326	R:R:Y327	2.42	Yes	Yes	0	8	9
241	R:R:D246	R:R:R263	2.38	No	No	0	6	7
242	R:R:H185	R:R:Y120	2.18	No	No	0	5	6
243	R:R:F112	R:R:Y104	2.06	No	No	0	8	4
244	R:R:F189	R:R:Y191	2.06	No	No	0	1	1
245	R:R:A321	R:R:G59	1.95	No	No	0	7	8
246	R:R:G118	R:R:V117	1.84	No	No	0	5	3
247	R:R:A147	R:R:A154	1.79	No	No	0	8	6
248	R:R:P47	R:R:V50	1.77	No	No	0	4	6
249	L:L:A12	R:R:S201	1.71	No	No	0	0	2
250	R:R:G59	R:R:L95	1.71	No	No	0	8	7
251	R:R:G168	R:R:L167	1.71	No	No	0	4	7
252	R:R:A321	R:R:V58	1.7	No	No	0	7	5
253	R:R:I187	R:R:P116	1.69	No	No	0	6	3
254	R:R:I134	R:R:P228	1.69	No	No	0	8	9
255	L:L:A12	R:R:T203	1.68	No	No	0	0	4
256	R:R:K208	R:R:P209	1.67	No	No	0	4	6
257	R:R:L179	R:R:P180	1.64	No	No	0	4	8
258	R:R:L227	R:R:P228	1.64	No	No	0	6	9
259	R:R:S49	R:R:V53	1.62	No	No	0	5	5
260	R:R:A202	R:R:I187	1.62	No	No	0	5	6
261	R:R:S233	R:R:V234	1.62	No	No	0	4	4
262	R:R:V53	R:R:V57	1.6	No	No	0	5	5
263	R:R:V60	R:R:V64	1.6	No	No	0	6	4
264	R:R:V272	R:R:V276	1.6	No	No	0	6	7
265	L:L:P10	L:L:Q8	1.58	No	No	0	0	0
266	R:R:I279	R:R:V276	1.54	No	No	0	5	7
267	R:R:I326	R:R:V276	1.54	Yes	No	0	8	7
268	R:R:I325	R:R:V322	1.54	No	No	0	7	6
269	R:R:I326	R:R:V322	1.54	Yes	No	0	8	6
270	R:R:H150	R:R:P151	1.53	No	No	0	6	8
271	R:R:K268	R:R:S265	1.53	No	No	0	6	7
272	R:R:F126	R:R:G98	1.51	Yes	No	0	6	6
273	R:R:F114	R:R:G118	1.51	No	No	0	7	5
274	L:L:G17	L:L:R16	1.5	No	No	0	0	0
275	R:R:L330	R:R:S331	1.5	No	No	0	7	8
276	R:R:L179	R:R:V175	1.49	No	No	0	4	4
277	R:R:L235	R:R:V234	1.49	Yes	No	0	8	4
278	R:R:L270	R:R:V274	1.49	No	No	0	8	8
279	R:R:L307	R:R:V310	1.49	No	No	0	1	4
280	R:R:I326	R:R:M269	1.46	Yes	No	0	8	8
281	R:R:F114	R:R:P111	1.44	No	Yes	0	7	4
282	R:R:F152	R:R:P151	1.44	No	No	0	6	8
283	R:R:F192	R:R:P193	1.44	Yes	No	0	3	1
284	R:R:I325	R:R:L65	1.43	No	No	0	7	7
285	R:R:Q157	R:R:T159	1.42	No	No	0	3	7
286	R:R:K122	R:R:L101	1.41	No	No	0	5	5
287	R:R:P111	R:R:Y110	1.39	Yes	No	0	4	4
288	R:R:L68	R:R:L71	1.38	No	No	0	4	3
289	R:R:L223	R:R:L227	1.38	No	No	0	4	6
290	R:R:L238	R:R:L241	1.38	No	No	0	4	3
291	R:R:E295	R:R:M210	1.35	No	No	0	3	3
292	R:R:V146	R:R:Y145	1.26	No	Yes	0	5	8
293	R:R:V234	R:R:Y237	1.26	No	No	0	4	4
294	R:R:I166	R:R:R162	1.25	No	No	0	5	4
295	R:R:F215	R:R:N214	1.21	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F11	10.266	5	2	0
2	L:L:F21	6.126	5	0	0
3	L:L:R24	4.72	4	0	0
4	L:L:N25	6.465	4	0	0
5	L:L:?26	6.7425	4	5	0
6	R:R:F44	4.7275	4	0	1
7	R:R:Y52	8.296	5	1	7
8	R:R:F56	8.6025	4	1	6
9	R:R:K77	14.6725	4	3	7
10	R:R:Y83	4.198	5	0	7
11	R:R:F85	6.502	5	3	5
12	R:R:M106	6.446	5	0	5
13	R:R:P111	2.65	5	7	4
14	R:R:F126	3.04	4	0	6
15	R:R:E127	6.575	4	5	4
16	R:R:F131	10.814	5	8	6
17	R:R:R144	6.14	4	0	9
18	R:R:Y145	6.362	5	0	8
19	R:R:H190	10.03	6	2	1
20	R:R:F192	5.472	5	2	3
21	R:R:L235	5.6725	4	0	8
22	R:R:Y236	7.408	5	9	9
23	R:R:N267	7.99	4	10	6
24	R:R:F277	6.7	4	0	9
25	R:R:W281	6.7175	4	0	8
26	R:R:D287	4.7375	4	4	5
27	R:R:R288	6.9075	4	0	5
28	R:R:F305	8.13	4	4	5
29	R:R:Y317	12.07	5	1	7
30	R:R:I326	2.248	5	0	8
31	R:R:Y327	4.0175	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E6	L:L:Q8	13.4769	8.92	No	No	0	0	0
2	L:L:F11	R:R:S201	11.989	3.96	Yes	No	2	0	2
3	R:R:H190	R:R:S201	17.5464	11.16	Yes	No	2	1	2
4	L:L:A12	R:R:S201	30.4765	1.71	No	No	0	0	2
5	L:L:A12	R:R:T203	31.4102	1.68	No	No	0	0	4
6	R:R:T203	R:R:T205	32.4034	4.71	No	No	0	4	4
7	R:R:T205	R:R:V206	36.2422	4.76	No	No	0	4	4
8	R:R:V206	R:R:Y213	37.1833	21.45	No	No	0	4	2
9	L:L:N25	R:R:Y213	41.7773	5.81	Yes	No	0	0	2
10	L:L:N25	L:L:P23	23.8515	8.15	Yes	No	0	0	0
11	L:L:P23	R:R:F291	23.2489	8.67	No	No	0	0	4
12	R:R:D287	R:R:F291	13.0826	7.17	Yes	No	4	5	4
13	R:R:D287	R:R:H309	13.1273	3.78	Yes	No	0	5	4
14	L:L:F21	R:R:H309	13.648	5.66	Yes	No	0	0	4
15	L:L:F21	R:R:E105	20.3586	3.5	Yes	No	0	0	4
16	L:L:F21	R:R:M106	27.642	6.22	Yes	Yes	0	0	5
17	L:L:R22	R:R:E105	18.0746	16.28	No	No	0	0	4
18	L:L:?26	L:L:N25	51.8432	6.8	Yes	Yes	0	0	0
19	L:L:?26	R:R:E127	53.3534	13.12	Yes	Yes	5	0	4
20	R:R:E127	R:R:R288	70.5464	3.49	Yes	Yes	0	4	5
21	R:R:F284	R:R:R288	58.6319	6.41	No	Yes	0	6	5
22	L:L:R24	R:R:F284	58.059	4.28	Yes	No	0	0	6
23	L:L:R24	R:R:E102	49.9349	5.82	Yes	No	0	0	6
24	L:L:R24	R:R:F126	14.1911	4.28	Yes	Yes	0	0	6
25	R:R:M106	R:R:V48	11.6282	7.61	Yes	No	0	5	6
26	R:R:F44	R:R:V48	13.4844	2.62	Yes	No	0	1	6
27	R:R:E102	R:R:Y52	22.7207	4.49	No	Yes	0	6	7
28	R:R:Y317	R:R:Y52	16.0213	21.84	Yes	Yes	1	7	7
29	R:R:R288	R:R:S221	100	3.95	Yes	No	0	5	5
30	R:R:H285	R:R:S221	99.8698	12.55	No	No	0	7	5
31	R:R:H285	R:R:Y225	99.7322	10.89	No	No	0	7	8
32	R:R:M229	R:R:Y225	99.4346	3.59	No	No	0	7	8
33	R:R:F277	R:R:M229	99.1072	4.98	Yes	No	0	9	7
34	R:R:F277	R:R:I137	44.5932	5.02	Yes	No	0	9	8
35	R:R:I137	R:R:Y327	43.0086	4.84	No	Yes	0	8	9
36	R:R:I326	R:R:Y327	15.3331	2.42	Yes	Yes	0	8	9
37	R:R:R144	R:R:Y327	34.1071	4.12	Yes	Yes	0	9	9
38	R:R:E143	R:R:R144	42.7408	6.98	No	Yes	0	8	9
39	R:R:E143	R:R:T80	41.1115	8.47	No	No	0	8	8
40	R:R:T78	R:R:T80	39.5417	4.71	No	No	0	8	8
41	R:R:N81	R:R:T78	36.2534	5.85	No	No	0	8	8
42	R:R:I70	R:R:N81	15.5972	4.25	No	No	3	7	8
43	R:R:F85	R:R:I70	13.8935	12.56	Yes	No	3	5	7
44	R:R:F277	R:R:I232	54.0081	3.77	Yes	No	0	9	8
45	R:R:I232	R:R:Y236	52.8103	4.84	No	Yes	9	8	9
46	R:R:R144	R:R:Y236	36.0339	8.23	Yes	Yes	0	9	9
47	R:R:K77	R:R:N81	18.9971	6.99	Yes	No	3	7	8
48	R:R:F85	R:R:K77	13.9531	3.72	Yes	Yes	3	5	7
49	R:R:C67	R:R:F85	13.9828	5.59	No	Yes	0	7	5
50	R:R:C67	R:R:L71	10.4973	4.76	No	No	0	7	3
51	R:R:R144	R:R:V140	22.7021	5.23	Yes	No	0	9	9
52	R:R:V140	R:R:Y83	21.0282	3.79	No	Yes	0	9	7
53	R:R:I166	R:R:Y83	12.4019	4.84	No	Yes	0	5	7
54	R:R:E127	R:R:S178	28.3599	5.75	Yes	No	0	4	7
55	R:R:S178	R:R:T128	27.3147	4.8	No	No	0	7	5
56	R:R:S174	R:R:T128	23.0592	4.8	No	No	0	8	5
57	L:L:R22	R:R:P111	16.9215	2.88	No	Yes	0	0	4
58	R:R:F131	R:R:S174	18.6847	9.25	Yes	No	0	6	8
59	R:R:F131	R:R:F224	11.8253	18.22	Yes	No	8	6	5
60	R:R:F224	R:R:I134	10.7428	5.02	No	No	0	5	8
61	R:R:M239	R:R:Y236	29.435	5.99	No	Yes	0	9	9
62	R:R:M239	R:R:Y145	17.5129	3.59	No	Yes	0	9	8
63	R:R:I148	R:R:M239	12.5581	7.29	No	No	0	8	9
64	R:R:I148	R:R:L243	11.5724	2.85	No	No	0	8	8
65	R:R:L243	R:R:R263	10.5606	6.07	No	No	0	8	7
66	R:R:E102	R:R:M106	32.05	5.41	No	Yes	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E5	R:R:P199	7.86	0	No	No	0	3	0	1
L:L:E6	R:R:H190	4.92	2	No	Yes	0	1	0	1
L:L:F11	R:R:H190	6.79	2	Yes	Yes	0	1	0	1
L:L:F11	R:R:S201	3.96	2	Yes	No	0	2	0	1
L:L:Q14	R:R:H43	6.18	0	No	No	0	5	0	1
L:L:Y18	R:R:W297	3.86	0	No	No	0	1	0	1
L:L:F19	R:R:W297	9.02	0	No	No	0	1	0	1
L:L:F19	R:R:F305	6.43	0	No	Yes	0	5	0	1
L:L:L20	R:R:H43	6.43	0	No	No	0	5	0	1
L:L:F21	R:R:H43	6.79	0	Yes	No	0	5	0	1
L:L:F21	R:R:E105	3.5	0	Yes	No	0	4	0	1
L:L:F21	R:R:M106	6.22	0	Yes	Yes	0	5	0	1
L:L:F21	R:R:N306	8.46	0	Yes	No	0	4	0	1
L:L:F21	R:R:H309	5.66	0	Yes	No	0	4	0	1
L:L:R22	R:R:E105	16.28	0	No	No	0	4	0	1
L:L:P23	R:R:F291	8.67	0	No	No	0	4	0	1
L:L:R24	R:R:E102	5.82	0	Yes	No	0	6	0	1
L:L:R24	R:R:F126	4.28	0	Yes	Yes	0	6	0	1
L:L:R24	R:R:F284	4.28	0	Yes	No	0	6	0	1
L:L:R24	R:R:G313	4.5	0	Yes	No	0	5	0	1
L:L:N25	R:R:H185	5.1	0	Yes	No	0	5	0	1
L:L:N25	R:R:Y213	5.81	0	Yes	No	0	2	0	1
L:L:?26	R:R:T123	3.65	5	Yes	No	0	5	0	1
L:L:?26	R:R:E127	13.12	5	Yes	Yes	0	4	0	1
L:L:?26	R:R:N181	3.4	5	Yes	No	0	4	0	1
R:R:F45	R:R:M106	9.95	0	No	Yes	4	5	2	1
R:R:V48	R:R:Y52	5.05	0	No	Yes	6	7	2	2
R:R:M106	R:R:V48	7.61	0	Yes	No	5	6	1	2
R:R:E102	R:R:Y52	4.49	0	No	Yes	6	7	1	2
R:R:F126	R:R:V94	3.93	0	Yes	No	6	7	1	2
R:R:E102	R:R:M106	5.41	0	No	Yes	6	5	1	1
R:R:M106	R:R:V103	3.04	0	Yes	No	5	6	1	2
R:R:E105	R:R:N109	11.83	0	No	No	4	2	1	2
R:R:C119	R:R:P111	3.77	7	No	Yes	9	4	2	1
R:R:C204	R:R:P111	3.77	7	No	Yes	9	4	2	1
R:R:C119	R:R:C204	7.28	7	No	No	9	9	2	2
R:R:T123	R:R:T182	4.71	0	No	No	5	5	1	2
R:R:E127	R:R:S178	5.75	5	Yes	No	4	7	1	2
R:R:E127	R:R:N181	3.94	5	Yes	No	4	4	1	1
R:R:E127	R:R:R288	3.49	5	Yes	Yes	4	5	1	2
R:R:F192	R:R:H190	14.71	2	Yes	Yes	3	1	2	1
R:R:H190	R:R:P199	19.83	2	Yes	No	1	3	1	1
R:R:H190	R:R:S201	11.16	2	Yes	No	1	2	1	1
R:R:F192	R:R:P199	5.78	2	Yes	No	3	3	2	1
R:R:T203	R:R:T205	4.71	0	No	No	4	4	1	2
R:R:T205	R:R:V206	4.76	0	No	No	4	4	2	2
R:R:V206	R:R:Y213	21.45	0	No	No	4	2	2	1
R:R:F284	R:R:R288	6.41	0	No	Yes	6	5	1	2
R:R:D287	R:R:F291	7.17	4	Yes	No	5	4	2	1
R:R:D287	R:R:F305	3.58	4	Yes	Yes	5	5	2	1
R:R:D287	R:R:H309	3.78	4	Yes	No	5	4	2	1
R:R:F290	R:R:F305	10.72	0	No	Yes	4	5	2	1
R:R:F291	R:R:F305	11.79	4	No	Yes	4	5	1	1
R:R:E295	R:R:W297	4.36	0	No	No	3	1	2	1
L:L:R22	R:R:P111	2.88	0	No	Yes	0	4	0	1
R:R:I216	R:R:N181	2.83	0	No	No	5	4	2	1
L:L:F19	R:R:A302	2.77	0	No	No	0	1	0	1
R:R:H190	R:R:V198	2.77	2	Yes	No	1	4	1	2
R:R:F126	R:R:L97	2.44	0	Yes	No	6	5	1	2
R:R:I184	R:R:Y213	2.42	0	No	No	5	2	2	1
R:R:H185	R:R:Y120	2.18	0	No	No	5	6	1	2
L:L:A12	R:R:S201	1.71	0	No	No	0	2	0	1
L:L:A12	R:R:T203	1.68	0	No	No	0	4	0	1
R:R:F126	R:R:G98	1.51	0	Yes	No	6	6	1	2
R:R:F114	R:R:P111	1.44	0	No	Yes	7	4	2	1
R:R:P111	R:R:Y110	1.39	7	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XK8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	282
Number of Links	295
Number of Hubs	31
Number of Links mediated by Hubs	123
Number of Communities	10
Number of Nodes involved in Communities	38
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	49031
Length Of Smallest Path	3
Average Path Length	16.1648
Length of Longest Path	34
Minimum Path Strength	1.375
Average Path Strength	6.33234
Maximum Path Strength	23.99
Minimum Path Correlation	0.7
Average Path Correlation	0.934405
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	49.5356
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.5947
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • neuromedin U receptor activity • neuromedin U binding • neuropeptide binding • peptide binding • monoatomic anion transmembrane transporter activity • chloride transmembrane transporter activity • gated channel activity • monoatomic ion channel activity • intracellularly calcium-gated channel activity • intracellularly calcium-gated chloride channel activity • ligand-gated monoatomic anion channel activity • ligand-gated channel activity • ligand-gated monoatomic ion channel activity • passive transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • monoatomic anion channel activity • transporter activity • transmembrane transporter activity • chloride channel activity • neuropeptide signaling pathway • response to stress • multicellular organismal response to stress • response to pain • organic anion transport • carboxylic acid transport • arachidonate transport • lipid localization • lipid transport • organic acid transport • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • icosanoid secretion • long-chain fatty acid transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • positive regulation of signaling • reduction of food intake in response to dietary excess • response to nutrient levels • homeostatic process • eating behavior • feeding behavior • behavior • multicellular organismal-level homeostasis • response to dietary excess • energy homeostasis • central nervous system development • nervous system development • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of multicellular organismal process • grooming behavior • type 2 neuromedin U receptor binding • neuromedin U receptor binding • neuropeptide receptor binding • type 1 neuromedin U receptor binding • positive regulation of smooth muscle contraction • stomach smooth muscle contraction • regulation of stomach fundus smooth muscle contraction • regulation of gastro-intestinal system smooth muscle contraction • gastro-intestinal system smooth muscle contraction • stomach fundus smooth muscle contraction • positive regulation of gastro-intestinal system smooth muscle contraction • proximal stomach smooth muscle contraction • positive regulation of muscle contraction • positive regulation of multicellular organismal process • positive regulation of stomach fundus smooth muscle contraction • tonic smooth muscle contraction • digestion • digestive system process • acid secretion • gastric acid secretion • heart process • regulation of heart contraction • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • regulation of heart rate • positive regulation of cytosolic calcium ion concentration • regulation of heat generation • positive regulation of heat generation • heat generation • temperature homeostasis • sensory perception of pain • regulation of nervous system process • positive regulation of nervous system process • regulation of sensory perception • regulation of sensory perception of pain • positive regulation of sensory perception of pain • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • negative regulation of digestive system process • regulation of gastric acid secretion • regulation of digestive system process • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • regulation of grooming behavior • regulation of gastric emptying • regulation of gastric motility • gastric emptying • negative regulation of gastric emptying • gastric motility • positive regulation of establishment of protein localization • positive regulation of prolactin secretion • positive regulation of peptide hormone secretion • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • prolactin secretion • positive regulation of protein secretion • positive regulation of transport • positive regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure • regulation of blood pressure • positive regulation of blood pressure • negative regulation of feeding behavior • negative regulation of behavior • regulation of eating behavior • negative regulation of eating behavior • regulation of feeding behavior • trans-synaptic signaling • modulation of chemical synaptic transmission • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • axon • axon terminus • presynapse • distal axon • terminal bouton • neuron projection terminus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?26
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ4
Sequence	>7XK8_nogp_Chain_R S H F F L P V S V V Y V P I F V V G V I G N V L V C L V I L Q H Q A M K T P T N Y Y L F S L A V S D L L V L L L G M P L E V Y E M W R N Y P F L F G P V G C Y F K T A L F E T V C F A S I L S I T T V S V E R Y V A I L H P F R A K L Q S T R R R A L R I L G I V W G F S V L F S L P N T S I H G I K F H Y F P N G S L V P G S A T C T V I K P M W I Y N F I I Q V T S F L F Y L L P M T V I S V L Y Y L M A L R L K K D K I Q R P C R K S V N K M L F V L V L V F A I C W A P F H I D R L F F S F V E E W S E S L A A V F N L V H V V S G V F F Y L S S A V N P I I Y N L L S R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7W55	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W55 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-		2.8	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W57	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-S	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W57 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-S	-		3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7XK8	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-	Gi1/β1/γ2	3.3	2023-02-22	doi.org/10.1038/s41467-022-34814-4
	7XK8 (No Gprot)	A	Peptide	Neuromedin U	NMUR2	Homo sapiens	Neuromedin-U-25	-		3.3	2023-02-22	doi.org/10.1038/s41467-022-34814-4

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