psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D39	R:R:S37	5.89	No	No	4	3	4
2	R:R:S37	R:R:V40	9.7	No	No	4	4	4
3	R:R:D39	R:R:V40	5.84	No	No	4	3	4
4	R:R:L305	R:R:Y48	8.21	No	No	0	4	8
5	R:R:L309	R:R:Y48	9.38	No	No	0	5	8
6	R:R:E51	R:R:Q95	17.84	No	Yes	0	7	7
7	R:R:E51	R:R:L309	6.63	No	No	0	7	5
8	R:R:C91	R:R:T52	5.07	No	No	5	6	7
9	R:R:Q95	R:R:T52	9.92	Yes	No	5	7	7
10	R:R:F88	R:R:V56	6.55	Yes	No	0	8	6
11	R:R:A84	R:R:N59	4.69	No	Yes	0	9	9
12	R:R:D87	R:R:N59	4.04	Yes	Yes	0	9	9
13	R:R:F88	R:R:N59	3.62	Yes	Yes	0	8	9
14	R:R:N59	R:R:P319	6.52	Yes	No	0	9	9
15	R:R:C61	R:R:E332	6.08	No	No	0	7	6
16	R:R:I80	R:R:L62	4.28	No	Yes	0	8	9
17	R:R:A84	R:R:L62	4.73	No	Yes	0	9	9
18	R:R:C64	R:R:R68	5.57	No	No	0	4	5
19	R:R:F329	R:R:V65	6.55	Yes	No	0	8	8
20	R:R:E332	R:R:V65	8.56	No	No	0	6	8
21	R:R:A81	R:R:T66	3.36	No	No	0	7	7
22	R:R:K331	R:R:R68	3.71	No	No	0	5	5
23	R:R:F329	R:R:Q69	9.37	Yes	No	0	8	6
24	R:R:E71	R:R:K70	4.05	No	No	0	6	6
25	R:R:N74	R:R:T76	4.39	No	No	6	8	8
26	R:R:N74	R:R:N77	16.35	No	No	6	8	8
27	R:R:E138	R:R:V75	5.7	Yes	No	0	8	6
28	R:R:P151	R:R:V75	3.53	Yes	No	0	5	6
29	R:R:N77	R:R:T76	4.39	No	No	6	8	8
30	R:R:E138	R:R:T76	9.88	Yes	No	0	8	8
31	R:R:F329	R:R:N77	9.67	Yes	No	0	8	8
32	R:R:L78	R:R:Y157	12.89	No	No	0	6	3
33	R:R:E138	R:R:L79	3.98	Yes	No	0	8	7
34	R:R:I80	R:R:Y322	4.84	No	Yes	0	8	9
35	R:R:N82	R:R:S131	5.96	No	No	0	9	8
36	R:R:I160	R:R:N82	15.58	No	No	0	8	9
37	R:R:D87	R:R:L83	5.43	Yes	Yes	2	9	9
38	R:R:L83	R:R:S131	7.51	Yes	No	0	9	8
39	R:R:L132	R:R:L83	6.92	Yes	Yes	2	9	9
40	R:R:L83	R:R:N318	5.49	Yes	Yes	2	9	9
41	R:R:L83	R:R:Y322	5.86	Yes	Yes	2	9	9
42	R:R:F85	R:R:L89	13.4	No	No	0	6	7
43	R:R:S86	R:R:V127	4.85	No	No	0	8	7
44	R:R:S128	R:R:S86	4.89	No	No	0	9	8
45	R:R:D87	R:R:S128	7.36	Yes	No	0	9	9
46	R:R:D87	R:R:T315	7.23	Yes	No	0	9	9
47	R:R:D87	R:R:N318	9.42	Yes	Yes	2	9	9
48	R:R:F88	R:R:L89	4.87	Yes	No	0	8	7
49	R:R:F88	R:R:L92	3.65	Yes	No	0	8	5
50	R:R:M90	R:R:S124	4.6	Yes	No	0	6	8
51	R:R:M90	R:R:V125	4.56	Yes	Yes	1	6	7
52	R:R:M90	R:R:S128	6.13	Yes	No	0	6	9
53	R:R:M90	R:R:W278	4.65	Yes	Yes	1	6	9
54	R:R:M312	R:R:M90	7.22	Yes	Yes	0	7	6
55	R:R:C91	R:R:Q95	9.16	No	Yes	5	6	7
56	R:R:C91	R:R:T315	6.76	No	No	0	6	9
57	R:R:I120	R:R:L93	7.14	No	No	0	4	4
58	R:R:C94	R:R:M312	4.86	No	Yes	0	7	7
59	R:R:M312	R:R:Q95	6.8	Yes	Yes	0	7	7
60	R:R:L97	R:R:S117	6.01	No	No	0	5	5
61	R:R:H308	R:R:T98	16.43	No	No	0	5	6
62	L:L:P34	R:R:T98	6.99	No	No	0	0	6
63	R:R:W107	R:R:Y101	12.54	Yes	Yes	0	8	5
64	R:R:V200	R:R:Y101	6.31	No	Yes	0	4	5
65	L:L:T32	R:R:Y101	9.99	No	Yes	0	0	5
66	L:L:P34	R:R:Y101	8.34	No	Yes	0	0	5
67	R:R:L305	R:R:T102	7.37	No	No	0	4	5
68	R:R:M104	R:R:Y106	7.18	No	No	0	4	4
69	R:R:D105	R:R:F194	4.78	No	Yes	0	4	4
70	L:L:I28	R:R:D105	4.2	No	No	0	0	4
71	L:L:T32	R:R:D105	7.23	No	No	0	0	4
72	R:R:K198	R:R:Y106	7.17	No	No	0	3	4
73	R:R:F109	R:R:W107	18.04	No	Yes	0	7	8
74	R:R:C114	R:R:W107	6.53	No	Yes	3	9	8
75	R:R:E181	R:R:W107	5.45	No	Yes	0	2	8
76	R:R:C201	R:R:W107	5.22	No	Yes	3	9	8
77	R:R:F109	R:R:I108	7.54	No	No	0	7	4
78	R:R:F109	R:R:L113	12.18	No	No	0	7	6
79	R:R:E111	R:R:K115	9.45	No	Yes	0	4	7
80	R:R:E111	R:R:E181	8.88	No	No	0	4	2
81	R:R:C114	R:R:I179	8.18	No	Yes	3	9	4
82	R:R:C114	R:R:C201	7.28	No	No	3	9	9
83	R:R:I179	R:R:K115	5.82	Yes	Yes	0	4	7
84	R:R:F119	R:R:M123	6.22	No	Yes	0	6	5
85	R:R:F119	R:R:L175	12.18	No	No	0	6	6
86	L:L:?36	R:R:Q121	9	Yes	No	0	0	7
87	R:R:C122	R:R:S171	3.44	No	No	0	6	7
88	R:R:C122	R:R:F174	5.59	No	Yes	0	6	5
89	R:R:M123	R:R:W164	5.82	Yes	No	0	5	9
90	R:R:M123	R:R:S171	4.6	Yes	No	0	5	7
91	R:R:Q222	R:R:V125	4.3	Yes	Yes	1	6	7
92	R:R:V125	R:R:W278	4.9	Yes	Yes	1	7	9
93	L:L:?36	R:R:V125	3.78	Yes	Yes	1	0	7
94	R:R:A167	R:R:T126	3.36	No	No	0	8	6
95	R:R:Q222	R:R:T126	7.09	Yes	No	0	6	6
96	R:R:V127	R:R:W164	15.94	No	No	0	7	9
97	R:R:I129	R:R:Q222	4.12	Yes	Yes	0	8	6
98	R:R:I129	R:R:P226	3.39	Yes	No	0	8	9
99	R:R:F274	R:R:I129	5.02	Yes	Yes	0	9	8
100	R:R:I129	R:R:W278	5.87	Yes	Yes	0	8	9
101	R:R:I163	R:R:L130	9.99	No	No	0	7	6
102	R:R:F274	R:R:L132	3.65	Yes	Yes	0	9	9
103	R:R:L132	R:R:N318	8.24	Yes	Yes	2	9	9
104	R:R:L132	R:R:Y322	3.52	Yes	Yes	2	9	9
105	R:R:P226	R:R:V133	3.53	No	No	0	9	7
106	R:R:I163	R:R:L134	8.56	No	No	0	7	7
107	R:R:R139	R:R:V135	5.23	No	No	0	9	9
108	R:R:A136	R:R:I230	4.87	No	No	2	9	8
109	R:R:A136	R:R:Y234	4	No	Yes	2	9	9
110	R:R:E138	R:R:L142	7.95	Yes	No	0	8	8
111	R:R:R139	R:R:Y322	7.2	No	Yes	0	9	9
112	R:R:N326	R:R:R139	4.82	No	No	0	8	9
113	R:R:H140	R:R:I144	10.61	No	No	0	8	7
114	R:R:C233	R:R:H140	8.85	No	No	0	7	8
115	R:R:H140	R:R:R236	11.28	No	No	0	8	4
116	R:R:N145	R:R:Q141	6.6	No	No	0	6	5
117	R:R:Q141	R:R:W149	7.67	No	No	0	5	6
118	R:R:L142	R:R:P151	3.28	No	Yes	0	8	5
119	R:R:I143	R:R:I237	14.72	No	No	0	8	8
120	R:R:I144	R:R:N145	5.66	No	No	0	7	6
121	R:R:I144	R:R:R240	6.26	No	No	0	7	5
122	R:R:P151	R:R:W149	12.16	Yes	No	0	5	6
123	R:R:Q155	R:R:W149	4.38	No	No	0	4	6
124	R:R:K150	R:R:P151	3.35	No	Yes	0	5	5
125	R:R:I153	R:R:Y157	3.63	No	No	0	6	3
126	R:R:L172	R:R:P173	4.93	No	No	0	4	8
127	R:R:P173	R:R:Y214	9.74	No	No	0	8	5
128	R:R:F174	R:R:S178	7.93	Yes	No	1	5	4
129	R:R:F174	R:R:W205	6.01	Yes	Yes	1	5	5
130	R:R:F174	R:R:Y214	6.19	Yes	No	1	5	5
131	R:R:N177	R:R:W205	3.39	No	Yes	0	5	5
132	R:R:E203	R:R:S178	8.62	No	No	1	5	4
133	R:R:S178	R:R:W205	8.65	No	Yes	1	4	5
134	R:R:C201	R:R:I179	4.91	No	Yes	3	9	4
135	R:R:L180	R:R:N182	5.49	No	No	0	5	3
136	R:R:L180	R:R:S204	7.51	No	No	0	5	4
137	R:R:E181	R:R:V199	4.28	No	No	0	2	5
138	R:R:A196	R:R:V183	3.39	No	No	0	2	1
139	R:R:F184	R:R:H188	7.92	No	No	0	3	4
140	L:L:Y27	R:R:F184	5.16	No	No	0	0	3
141	L:L:E4	R:R:H185	7.39	Yes	No	0	0	3
142	R:R:K186	R:R:S189	6.12	No	No	0	2	4
143	L:L:E4	R:R:N187	10.52	Yes	No	0	0	1
144	L:L:E4	R:R:H188	11.08	Yes	No	0	0	4
145	L:L:L24	R:R:H188	5.14	No	No	0	0	4
146	L:L:Y7	R:R:K190	5.97	Yes	No	0	0	7
147	R:R:F194	R:R:L192	14.61	Yes	No	0	4	5
148	L:L:I28	R:R:L192	4.28	No	No	0	0	5
149	R:R:E193	R:R:F194	8.16	No	Yes	0	2	4
150	R:R:D197	R:R:F194	4.78	No	Yes	7	5	4
151	R:R:F194	R:R:K198	8.69	Yes	No	7	4	3
152	R:R:D197	R:R:K198	6.91	No	No	7	5	3
153	L:L:L31	R:R:T202	5.9	No	No	0	0	3
154	R:R:E203	R:R:W205	15.27	No	Yes	1	5	5
155	R:R:E203	R:R:R211	10.47	No	Yes	1	5	3
156	R:R:R211	R:R:W205	9	Yes	Yes	1	3	5
157	R:R:W205	R:R:Y214	6.75	Yes	No	1	5	5
158	R:R:H210	R:R:L207	9	No	No	0	3	3
159	R:R:D289	R:R:R211	13.1	Yes	Yes	1	5	3
160	L:L:A1	R:R:R211	4.15	No	Yes	0	0	3
161	R:R:T212	R:R:W290	7.28	No	No	0	2	4
162	R:R:F217	R:R:I213	6.28	No	No	0	3	4
163	R:R:D289	R:R:T215	7.23	Yes	No	1	5	5
164	L:L:R35	R:R:T215	9.06	Yes	No	1	0	5
165	R:R:F217	R:R:L220	3.65	No	No	0	3	5
166	R:R:L218	R:R:Q222	10.65	No	Yes	1	5	6
167	L:L:?36	R:R:L218	10.53	Yes	No	1	0	5
168	R:R:H282	R:R:L219	3.86	Yes	No	0	8	6
169	R:R:L219	R:R:S286	7.51	No	No	0	6	6
170	R:R:H282	R:R:Q222	3.71	Yes	Yes	1	8	6
171	L:L:?36	R:R:Q222	6.75	Yes	Yes	1	0	6
172	R:R:L227	R:R:Y223	4.69	No	No	0	7	8
173	R:R:L279	R:R:Y223	9.38	No	No	0	5	8
174	R:R:H282	R:R:Y223	10.89	Yes	No	0	8	8
175	R:R:L225	R:R:P226	3.28	No	No	0	6	9
176	R:R:F229	R:R:L225	10.96	No	No	0	7	6
177	R:R:F274	R:R:L227	6.09	Yes	No	0	9	7
178	R:R:A275	R:R:L227	4.73	No	No	0	6	7
179	R:R:I230	R:R:Y234	4.84	No	Yes	2	8	9
180	R:R:F274	R:R:I230	7.54	Yes	No	0	9	8
181	R:R:R236	R:R:V232	5.23	No	No	0	4	5
182	R:R:L267	R:R:Y234	7.03	No	Yes	0	8	9
183	R:R:M270	R:R:Y234	9.58	Yes	Yes	2	8	9
184	R:R:V271	R:R:Y234	3.79	No	Yes	0	8	9
185	R:R:Q242	R:R:Y238	15.78	No	No	0	4	6
186	R:R:N264	R:R:Y238	5.81	No	No	0	7	6
187	R:R:R240	R:R:R243	9.6	No	No	0	5	4
188	R:R:Q244	R:R:R240	3.5	No	No	0	6	5
189	R:R:G245	R:R:R256	4.5	No	No	0	4	4
190	R:R:F248	R:R:V247	11.8	No	No	0	4	1
191	R:R:H249	R:R:R256	14.67	No	No	0	2	4
192	R:R:M260	R:R:R256	8.69	No	No	0	7	4
193	R:R:Q262	R:R:V266	4.3	No	Yes	0	8	8
194	R:R:M270	R:R:V266	4.56	Yes	Yes	0	8	8
195	R:R:I321	R:R:M270	7.29	No	Yes	2	8	8
196	R:R:M270	R:R:Y322	10.78	Yes	Yes	2	8	9
197	R:R:H282	R:R:W278	6.35	Yes	Yes	1	8	9
198	R:R:A311	R:R:W278	3.89	No	Yes	0	8	9
199	R:R:S314	R:R:W278	11.12	No	Yes	0	9	9
200	R:R:L279	R:R:P280	3.28	No	No	0	5	9
201	R:R:C307	R:R:P280	3.77	No	No	0	7	9
202	R:R:L281	R:R:N285	5.49	No	Yes	0	7	6
203	R:R:F304	R:R:L281	3.65	No	No	0	4	7
204	R:R:A311	R:R:L281	4.73	No	No	0	8	7
205	L:L:?36	R:R:H282	4.35	Yes	Yes	1	0	8
206	R:R:E288	R:R:F284	4.66	Yes	Yes	0	4	4
207	R:R:F284	R:R:I295	3.77	Yes	No	0	4	2
208	R:R:F284	R:R:I303	3.77	Yes	No	0	4	5
209	R:R:F284	R:R:F304	11.79	Yes	No	0	4	4
210	L:L:R33	R:R:N285	7.23	Yes	Yes	1	0	6
211	L:L:R35	R:R:N285	4.82	Yes	Yes	1	0	6
212	L:L:?36	R:R:N285	4.64	Yes	Yes	1	0	6
213	R:R:D289	R:R:E288	5.2	Yes	Yes	0	5	4
214	L:L:M30	R:R:E288	12.18	No	Yes	0	0	4
215	L:L:R33	R:R:E288	18.61	Yes	Yes	0	0	4
216	L:L:R35	R:R:D289	5.96	Yes	Yes	1	0	5
217	R:R:E293	R:R:H291	3.69	No	No	0	1	3
218	R:R:A294	R:R:H291	7.32	No	No	0	1	3
219	R:R:E293	R:R:H292	7.39	No	No	9	1	1
220	L:L:R26	R:R:H292	3.39	Yes	No	9	0	1
221	L:L:R26	R:R:E293	9.3	Yes	No	9	0	1
222	R:R:I295	R:R:P296	3.39	No	No	0	2	1
223	R:R:G300	R:R:I295	3.53	No	No	0	3	2
224	L:L:R26	R:R:I297	5.01	Yes	No	0	0	1
225	R:R:G300	R:R:I303	3.53	No	No	0	3	5
226	L:L:N29	R:R:N301	16.35	No	No	0	0	4
227	L:L:R33	R:R:F304	17.1	Yes	No	0	0	4
228	R:R:H308	R:R:M312	10.51	No	Yes	0	5	7
229	L:L:?36	R:R:H308	7.61	Yes	No	0	0	5
230	R:R:N318	R:R:S314	4.47	Yes	No	0	9	9
231	R:R:N318	R:R:Y322	6.98	Yes	Yes	2	9	9
232	R:R:F320	R:R:F324	11.79	No	No	0	6	7
233	R:R:I321	R:R:Y322	6.04	No	Yes	2	8	9
234	R:R:F324	R:R:L325	3.65	No	No	0	7	7
235	R:R:F329	R:R:N328	7.25	Yes	No	0	8	7
236	L:L:M30	L:L:P2	10.06	No	No	0	0	0
237	L:L:L31	L:L:P2	3.28	No	No	0	0	0
238	L:L:E4	L:L:Y27	5.61	Yes	No	0	0	0
239	L:L:P5	L:L:Y20	8.34	No	No	0	0	0
240	L:L:D23	L:L:P5	6.44	No	No	0	0	0
241	L:L:P8	L:L:Y7	4.17	No	Yes	8	0	0
242	L:L:M17	L:L:Y7	4.79	No	Yes	8	0	0
243	L:L:Y20	L:L:Y7	11.91	No	Yes	0	0	0
244	L:L:M17	L:L:P8	3.35	No	No	8	0	0
245	L:L:E15	L:L:T13	4.23	No	No	0	0	0
246	L:L:Q16	L:L:T13	5.67	No	No	0	0	0
247	L:L:E15	L:L:P14	7.86	No	No	0	0	0
248	L:L:L24	L:L:Y20	3.52	No	No	0	0	0
249	L:L:D23	L:L:R26	11.91	No	Yes	0	0	0
250	L:L:N29	L:L:R25	16.87	No	No	0	0	0
251	L:L:L31	L:L:Y27	16.41	No	No	0	0	0
252	L:L:R33	L:L:R35	4.26	Yes	Yes	1	0	0
253	L:L:?36	L:L:R35	9.24	Yes	Yes	1	0	0
254	R:R:C298	R:R:I297	3.27	No	No	0	1	1
255	R:R:A118	R:R:I179	3.25	No	Yes	0	5	4
256	R:R:V183	R:R:V199	3.21	No	No	0	1	5
257	R:R:C233	R:R:L137	3.17	No	No	0	7	7
258	R:R:C224	R:R:L220	3.17	No	No	0	5	5
259	R:R:P96	R:R:Q95	3.16	No	Yes	0	9	7
260	L:L:L24	R:R:A191	3.15	No	No	0	0	5
261	R:R:A313	R:R:L277	3.15	No	No	0	5	8
262	R:R:C340	R:R:Q341	3.05	No	No	0	6	4
263	R:R:C316	R:R:E51	3.04	No	No	0	8	7
264	R:R:K72	R:R:V67	3.04	No	No	0	7	4
265	R:R:M104	R:R:V100	3.04	No	No	0	4	5
266	R:R:L309	R:R:S47	3	No	No	0	5	5
267	R:R:K115	R:R:T112	3	Yes	No	0	7	3
268	R:R:L277	R:R:S314	3	No	No	0	8	9
269	R:R:L302	R:R:V40	2.98	No	No	0	2	4
270	R:R:L57	R:R:V53	2.98	No	No	0	5	5
271	R:R:L60	R:R:V56	2.98	No	No	0	4	6
272	R:R:L79	R:R:V135	2.98	No	No	0	7	9
273	R:R:L137	R:R:V133	2.98	No	No	0	7	7
274	R:R:L231	R:R:V271	2.98	No	No	0	5	8
275	R:R:L241	R:R:V263	2.98	No	No	0	8	8
276	R:R:L267	R:R:V263	2.98	No	No	0	8	8
277	R:R:L325	R:R:V266	2.98	No	Yes	0	7	8
278	R:R:L277	R:R:V317	2.98	No	No	0	8	6
279	R:R:L62	R:R:T66	2.95	Yes	No	0	9	7
280	R:R:L130	R:R:T126	2.95	No	No	0	6	6
281	R:R:I103	R:R:M104	2.92	No	No	0	5	4
282	R:R:I120	R:R:M123	2.92	No	Yes	0	4	5
283	R:R:N182	R:R:T202	2.92	No	No	0	3	3
284	R:R:K331	R:R:K334	2.87	No	No	0	5	5
285	R:R:I44	R:R:L302	2.85	No	No	0	5	2
286	R:R:I166	R:R:L130	2.85	No	No	0	5	6
287	R:R:I237	R:R:L267	2.85	No	No	0	8	8
288	R:R:I333	R:R:L336	2.85	No	No	0	6	6
289	R:R:L241	R:R:M260	2.83	No	No	0	8	7
290	R:R:L170	R:R:L218	2.77	No	No	0	5	5
291	R:R:K331	R:R:Q69	2.71	No	No	0	5	6
292	L:L:D10	L:L:N11	2.69	No	No	0	0	0
293	R:R:L338	R:R:Q341	2.66	No	No	0	4	4
294	R:R:E71	R:R:Q69	2.55	No	No	0	6	6
295	R:R:F324	R:R:I333	2.51	No	No	0	7	6
296	R:R:F221	R:R:L170	2.44	No	No	0	4	5
297	R:R:F221	R:R:L225	2.44	No	No	0	4	6
298	R:R:I44	R:R:Y48	2.42	No	No	0	5	8
299	R:R:F248	R:R:Q244	2.34	No	No	0	4	6
300	R:R:L97	R:R:W107	2.28	No	Yes	0	5	8
301	R:R:C316	R:R:G55	1.96	No	No	0	8	8
302	R:R:A257	R:R:G258	1.95	No	No	0	3	4
303	R:R:G55	R:R:V54	1.84	No	No	0	8	5
304	R:R:G148	R:R:T147	1.82	No	No	0	5	6
305	R:R:P146	R:R:T147	1.75	No	No	0	8	6
306	R:R:G258	R:R:K261	1.74	No	No	0	4	5
307	R:R:G58	R:R:L57	1.71	No	No	0	8	5
308	R:R:G323	R:R:L62	1.71	No	Yes	0	7	9
309	R:R:G110	R:R:L113	1.71	No	No	0	8	6
310	R:R:G159	R:R:L134	1.71	No	No	0	5	7
311	R:R:G159	R:R:L158	1.71	No	No	0	5	3
312	R:R:G159	R:R:L162	1.71	No	No	0	5	3
313	R:R:A156	R:R:V75	1.7	No	No	0	7	6
314	L:L:D10	L:L:G9	1.68	No	No	0	0	0
315	R:R:L207	R:R:P206	1.64	No	No	0	3	5
316	R:R:L310	R:R:P280	1.64	No	No	0	7	9
317	R:R:N145	R:R:P146	1.63	No	No	0	6	8
318	R:R:C168	R:R:M123	1.62	No	Yes	0	3	5
319	R:R:A273	R:R:I321	1.62	No	No	0	6	8
320	L:L:A22	R:R:I297	1.62	No	No	0	0	1
321	R:R:A81	R:R:M63	1.61	No	No	0	7	8
322	R:R:A84	R:R:M63	1.61	No	No	0	9	8
323	R:R:A176	R:R:K115	1.61	No	Yes	0	4	7
324	L:L:A12	L:L:M17	1.61	No	No	0	0	0
325	R:R:V266	R:R:V269	1.6	Yes	No	0	8	6
326	R:R:V268	R:R:V271	1.6	No	No	0	5	8
327	R:R:V269	R:R:V272	1.6	No	No	0	6	5
328	R:R:V272	R:R:V276	1.6	No	No	0	5	5
329	R:R:C224	R:R:L219	1.59	No	No	0	5	6
330	R:R:A156	R:R:L78	1.58	No	No	0	7	6
331	R:R:A196	R:R:L195	1.58	No	No	0	2	1
332	R:R:T212	R:R:T215	1.57	No	No	0	2	5
333	R:R:I103	R:R:V45	1.54	No	No	0	5	5
334	L:L:A12	L:L:D10	1.54	No	No	0	0	0
335	R:R:H299	R:R:P296	1.53	No	No	0	4	1
336	R:R:M41	R:R:V42	1.52	No	No	0	4	7
337	R:R:M63	R:R:V67	1.52	No	No	0	8	4
338	R:R:L195	R:R:S189	1.5	No	No	0	1	4
339	R:R:K330	R:R:T327	1.5	No	No	0	8	5
340	R:R:L162	R:R:V165	1.49	No	No	0	3	4
341	R:R:L302	R:R:V306	1.49	No	No	0	2	6
342	R:R:N301	R:R:T102	1.46	No	No	0	4	5
343	L:L:N29	L:L:T32	1.46	No	No	0	0	0
344	R:R:Q341	R:R:V337	1.43	No	No	0	4	7
345	R:R:L113	R:R:M116	1.41	No	No	0	6	5
346	R:R:P206	R:R:W205	1.35	No	Yes	0	5	5
347	R:R:H259	R:R:M260	1.31	No	No	0	5	7
348	R:R:F217	R:R:T216	1.3	No	No	0	3	4
349	L:L:Q16	L:L:Q19	1.28	No	No	0	0	0
350	R:R:F43	R:R:I44	1.26	No	No	0	5	5
351	R:R:R239	R:R:Y238	1.03	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N59	4.7175	4	0	9
2	R:R:L62	3.4175	4	0	9
3	R:R:L83	6.242	5	2	9
4	R:R:D87	6.696	5	2	9
5	R:R:F88	4.6725	4	0	8
6	R:R:M90	5.432	5	1	6
7	R:R:Q95	9.376	5	5	7
8	R:R:Y101	9.295	4	0	5
9	R:R:W107	8.34333	6	3	8
10	R:R:K115	4.97	4	0	7
11	R:R:M123	4.236	5	0	5
12	R:R:V125	4.385	4	1	7
13	R:R:I129	4.6	4	0	8
14	R:R:L132	5.5825	4	2	9
15	R:R:E138	6.8775	4	0	8
16	R:R:P151	5.58	4	0	5
17	R:R:F174	6.43	4	1	5
18	R:R:I179	5.54	4	3	4
19	R:R:F194	8.204	5	7	4
20	R:R:W205	7.20286	7	1	5
21	R:R:R211	9.18	4	1	3
22	R:R:Q222	6.10333	6	1	6
23	R:R:Y234	5.848	5	2	9
24	R:R:V266	3.36	4	0	8
25	R:R:M270	8.0525	4	2	8
26	R:R:F274	5.575	4	0	9
27	R:R:W278	6.13	6	1	9
28	R:R:H282	5.832	5	1	8
29	R:R:F284	5.9975	4	0	4
30	R:R:N285	5.545	4	1	6
31	R:R:E288	10.1625	4	0	4
32	R:R:D289	7.8725	4	1	5
33	R:R:M312	7.3475	4	0	7
34	R:R:N318	6.92	5	2	9
35	R:R:Y322	6.46	7	2	9
36	R:R:F329	8.21	4	0	8
37	L:L:E4	8.65	4	0	0
38	L:L:Y7	6.71	4	8	0
39	L:L:R26	7.4025	4	9	0
40	L:L:R33	11.8	4	1	0
41	L:L:R35	6.668	5	1	0
42	L:L:?36	6.9875	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E51	R:R:Q95	12.2517	17.84	No	Yes	0	7	7
2	R:R:D87	R:R:N59	11.0501	4.04	Yes	Yes	0	9	9
3	R:R:F329	R:R:N77	21.8702	9.67	Yes	No	0	8	8
4	R:R:N77	R:R:T76	23.6664	4.39	No	No	6	8	8
5	R:R:E138	R:R:T76	27.3003	9.88	Yes	No	0	8	8
6	R:R:E138	R:R:L79	47.603	3.98	Yes	No	0	8	7
7	R:R:L79	R:R:V135	49.2869	2.98	No	No	0	7	9
8	R:R:R139	R:R:V135	50.8808	5.23	No	No	0	9	9
9	R:R:R139	R:R:Y322	54.1544	7.2	No	Yes	0	9	9
10	R:R:N318	R:R:Y322	56.6893	6.98	Yes	Yes	2	9	9
11	R:R:F329	R:R:Q69	12.8726	9.37	Yes	No	0	8	6
12	R:R:E138	R:R:V75	13.8276	5.7	Yes	No	0	8	6
13	R:R:M312	R:R:Q95	11.2303	6.8	Yes	Yes	0	7	7
14	R:R:M312	R:R:M90	16.1144	7.22	Yes	Yes	0	7	6
15	R:R:M90	R:R:S128	18.986	6.13	Yes	No	0	6	9
16	L:L:T32	R:R:Y101	16.8919	9.99	No	Yes	0	0	5
17	R:R:W107	R:R:Y101	30.1166	12.54	Yes	Yes	0	8	5
18	R:R:H308	R:R:M312	22.1987	10.51	No	Yes	0	5	7
19	R:R:H308	R:R:T98	47.9287	16.43	No	No	0	5	6
20	L:L:P34	R:R:T98	47.0639	6.99	No	No	0	0	6
21	L:L:P34	R:R:Y101	46.2088	8.34	No	Yes	0	0	5
22	L:L:T32	R:R:D105	12.8713	7.23	No	No	0	0	4
23	R:R:E181	R:R:W107	10.8686	5.45	No	Yes	0	2	8
24	L:L:?36	R:R:H308	43.6572	7.61	Yes	No	0	0	5
25	L:L:R35	R:R:D289	37.128	5.96	Yes	Yes	1	0	5
26	L:L:?36	L:L:R35	69.7393	9.24	Yes	Yes	1	0	0
27	L:L:?36	R:R:Q222	39.8001	6.75	Yes	Yes	1	0	6
28	R:R:I129	R:R:P226	13.4783	3.39	Yes	No	0	8	9
29	R:R:F274	R:R:I129	32.711	5.02	Yes	Yes	0	9	8
30	R:R:P226	R:R:V133	11.3786	3.53	No	No	0	9	7
31	R:R:F274	R:R:I230	12.2753	7.54	Yes	No	0	9	8
32	R:R:M270	R:R:Y322	22.4814	10.78	Yes	Yes	2	8	9
33	R:R:I230	R:R:Y234	11.1291	4.84	No	Yes	2	8	9
34	R:R:L137	R:R:V133	10.7411	2.98	No	No	0	7	7
35	R:R:C233	R:R:L137	10.1673	3.17	No	No	0	7	7
36	L:L:?36	R:R:N285	32.8136	4.64	Yes	Yes	1	0	6
37	L:L:R33	R:R:N285	35.7781	7.23	Yes	Yes	1	0	6
38	L:L:R33	R:R:E288	68.2078	18.61	Yes	Yes	0	0	4
39	L:L:M30	R:R:E288	100	12.18	No	Yes	0	0	4
40	L:L:M30	L:L:P2	98.2814	10.06	No	No	0	0	0
41	L:L:L31	L:L:P2	96.5601	3.28	No	No	0	0	0
42	L:L:R33	L:L:R35	31.0548	4.26	Yes	Yes	1	0	0
43	R:R:D289	R:R:E288	31.7658	5.2	Yes	Yes	0	5	4
44	L:L:L31	L:L:Y27	87.9118	16.41	No	No	0	0	0
45	L:L:Y27	R:R:F184	41.2318	5.16	No	No	0	0	3
46	R:R:F184	R:R:H188	39.5618	7.92	No	No	0	3	4
47	L:L:E4	L:L:Y27	44.942	5.61	Yes	No	0	0	0
48	L:L:E4	R:R:H188	39.717	11.08	Yes	No	0	0	4
49	L:L:L24	R:R:H188	75.6795	5.14	No	No	0	0	4
50	L:L:Y20	L:L:Y7	29.0813	11.91	No	Yes	0	0	0
51	L:L:L24	L:L:Y20	68.4906	3.52	No	No	0	0	0
52	R:R:H282	R:R:W278	22.3262	6.35	Yes	Yes	1	8	9
53	L:L:?36	R:R:H282	26.0641	4.35	Yes	Yes	1	0	8
54	R:R:M270	R:R:V266	21.9658	4.56	Yes	Yes	0	8	8
55	R:R:A311	R:R:W278	16.7256	3.89	No	Yes	0	8	9
56	R:R:S314	R:R:W278	58.7169	11.12	No	Yes	0	9	9
57	R:R:A311	R:R:L281	16.5371	4.73	No	No	0	8	7
58	R:R:F304	R:R:L281	12.7521	3.65	No	No	0	4	7
59	L:L:P5	L:L:Y20	36.23	8.34	No	No	0	0	0
60	L:L:D23	L:L:P5	32.7152	6.44	No	No	0	0	0
61	L:L:D23	L:L:R26	29.0923	11.91	No	Yes	0	0	0
62	L:L:R26	R:R:E293	10.9254	9.3	Yes	No	9	0	1
63	L:L:R26	R:R:I297	10.9296	5.01	Yes	No	0	0	1
64	R:R:L325	R:R:V266	10.9323	2.98	No	Yes	0	7	8
65	L:L:M17	L:L:Y7	18.1933	4.79	No	Yes	8	0	0
66	L:L:A12	L:L:D10	10.9296	1.54	No	No	0	0	0
67	L:L:A12	L:L:M17	14.5677	1.61	No	No	0	0	0
68	R:R:D87	R:R:S128	19.0318	7.36	Yes	No	0	9	9
69	R:R:F274	R:R:L132	21.6789	3.65	Yes	Yes	0	9	9
70	R:R:N318	R:R:S314	54.5702	4.47	Yes	No	0	9	9
71	L:L:?36	R:R:V125	27.1673	3.78	Yes	Yes	1	0	7
72	R:R:L132	R:R:Y322	18.5578	3.52	Yes	Yes	2	9	9
73	R:R:V125	R:R:W278	19.6624	4.9	Yes	Yes	1	7	9
74	R:R:I129	R:R:Q222	37.6353	4.12	Yes	Yes	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M90	R:R:V125	4.56	1	Yes	Yes	6	7	2	1
R:R:M90	R:R:W278	4.65	1	Yes	Yes	6	9	2	2
R:R:M312	R:R:M90	7.22	0	Yes	Yes	7	6	2	2
R:R:H308	R:R:T98	16.43	0	No	No	5	6	1	1
L:L:P34	R:R:T98	6.99	0	No	No	0	6	0	1
R:R:W107	R:R:Y101	12.54	3	Yes	Yes	8	5	2	1
R:R:V200	R:R:Y101	6.31	0	No	Yes	4	5	2	1
L:L:T32	R:R:Y101	9.99	0	No	Yes	0	5	0	1
L:L:P34	R:R:Y101	8.34	0	No	Yes	0	5	0	1
R:R:D105	R:R:F194	4.78	0	No	Yes	4	4	1	2
L:L:I28	R:R:D105	4.2	0	No	No	0	4	0	1
L:L:T32	R:R:D105	7.23	0	No	No	0	4	0	1
L:L:?36	R:R:Q121	9	1	Yes	No	0	7	0	1
R:R:Q222	R:R:V125	4.3	1	Yes	Yes	6	7	1	1
R:R:V125	R:R:W278	4.9	1	Yes	Yes	7	9	1	2
L:L:?36	R:R:V125	3.78	1	Yes	Yes	0	7	0	1
R:R:Q222	R:R:T126	7.09	1	Yes	No	6	6	1	2
R:R:I129	R:R:Q222	4.12	0	Yes	Yes	8	6	2	1
R:R:I129	R:R:W278	5.87	0	Yes	Yes	8	9	2	2
R:R:F184	R:R:H188	7.92	0	No	No	3	4	1	1
L:L:Y27	R:R:F184	5.16	0	No	No	0	3	0	1
L:L:E4	R:R:H185	7.39	0	Yes	No	0	3	0	1
L:L:E4	R:R:N187	10.52	0	Yes	No	0	1	0	1
L:L:E4	R:R:H188	11.08	0	Yes	No	0	4	0	1
L:L:L24	R:R:H188	5.14	0	No	No	0	4	0	1
L:L:Y7	R:R:K190	5.97	8	Yes	No	0	7	0	1
R:R:F194	R:R:L192	14.61	7	Yes	No	4	5	2	1
L:L:I28	R:R:L192	4.28	0	No	No	0	5	0	1
L:L:L31	R:R:T202	5.9	0	No	No	0	3	0	1
R:R:E203	R:R:W205	15.27	1	No	Yes	5	5	2	2
R:R:E203	R:R:R211	10.47	1	No	Yes	5	3	2	1
R:R:R211	R:R:W205	9	1	Yes	Yes	3	5	1	2
R:R:D289	R:R:R211	13.1	1	Yes	Yes	5	3	1	1
L:L:A1	R:R:R211	4.15	0	No	Yes	0	3	0	1
R:R:D289	R:R:T215	7.23	1	Yes	No	5	5	1	1
L:L:R35	R:R:T215	9.06	1	Yes	No	0	5	0	1
R:R:L218	R:R:Q222	10.65	1	No	Yes	5	6	1	1
L:L:?36	R:R:L218	10.53	1	Yes	No	0	5	0	1
R:R:H282	R:R:L219	3.86	1	Yes	No	8	6	1	2
R:R:H282	R:R:Q222	3.71	1	Yes	Yes	8	6	1	1
L:L:?36	R:R:Q222	6.75	1	Yes	Yes	0	6	0	1
R:R:H282	R:R:Y223	10.89	1	Yes	No	8	8	1	2
R:R:H282	R:R:W278	6.35	1	Yes	Yes	8	9	1	2
R:R:L281	R:R:N285	5.49	0	No	Yes	7	6	2	1
R:R:F304	R:R:L281	3.65	0	No	No	4	7	1	2
L:L:?36	R:R:H282	4.35	1	Yes	Yes	0	8	0	1
R:R:E288	R:R:F284	4.66	0	Yes	Yes	4	4	1	2
R:R:F284	R:R:F304	11.79	0	Yes	No	4	4	2	1
L:L:R33	R:R:N285	7.23	1	Yes	Yes	0	6	0	1
L:L:R35	R:R:N285	4.82	1	Yes	Yes	0	6	0	1
L:L:?36	R:R:N285	4.64	1	Yes	Yes	0	6	0	1
R:R:D289	R:R:E288	5.2	1	Yes	Yes	5	4	1	1
L:L:M30	R:R:E288	12.18	0	No	Yes	0	4	0	1
L:L:R33	R:R:E288	18.61	1	Yes	Yes	0	4	0	1
L:L:R35	R:R:D289	5.96	1	Yes	Yes	0	5	0	1
R:R:E293	R:R:H291	3.69	9	No	No	1	3	1	2
R:R:E293	R:R:H292	7.39	9	No	No	1	1	1	1
L:L:R26	R:R:H292	3.39	9	Yes	No	0	1	0	1
L:L:R26	R:R:E293	9.3	9	Yes	No	0	1	0	1
L:L:R26	R:R:I297	5.01	9	Yes	No	0	1	0	1
L:L:N29	R:R:N301	16.35	0	No	No	0	4	0	1
L:L:R33	R:R:F304	17.1	1	Yes	No	0	4	0	1
R:R:H308	R:R:M312	10.51	0	No	Yes	5	7	1	2
L:L:?36	R:R:H308	7.61	1	Yes	No	0	5	0	1
R:R:C298	R:R:I297	3.27	0	No	No	1	1	2	1
L:L:L24	R:R:A191	3.15	0	No	No	0	5	0	1
R:R:N182	R:R:T202	2.92	0	No	No	3	3	2	1
R:R:L170	R:R:L218	2.77	0	No	No	5	5	2	1
L:L:A22	R:R:I297	1.62	0	No	No	0	1	0	1
R:R:T212	R:R:T215	1.57	0	No	No	2	5	2	1
R:R:N301	R:R:T102	1.46	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X9C_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	311
Number of Links	351
Number of Hubs	42
Number of Links mediated by Hubs	152
Number of Communities	9
Number of Nodes involved in Communities	50
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	139140
Length Of Smallest Path	3
Average Path Length	17.5096
Length of Longest Path	34
Minimum Path Strength	1.495
Average Path Strength	7.17119
Maximum Path Strength	17.855
Minimum Path Correlation	0.7
Average Path Correlation	0.92963
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	43.3347
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3144
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• pancreatic polypeptide receptor activity • peptide receptor activity • molecular transducer activity • neuropeptide Y receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • binding • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • behavior • feeding behavior
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYC
PDB Residues	L:L:?36
Environment Details	Open EMBL-EBI Page
Code	TYC
Name	L-tyrosinamide
Synonyms	L-tyrosinamide (2S)-2-amino-3-(4-hydroxyphenyl)propanamide L-Tyrosine amide Tyrosinamide Tyrosine amide
Identifier
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P50391
Sequence	>7X9C_nogp_Chain_R Q D S V D V M V F I V T S Y S I E T V V G V L G N L C L M C V T V R Q K E K A N V T N L L I A N L A F S D F L M C L L C Q P L T A V Y T I M D Y W I F G E T L C K M S A F I Q C M S V T V S I L S L V L V A L E R H Q L I I N P T G W K P S I S Q A Y L G I V L I W V I A C V L S L P F L A N S I L E N V F H K N H S K A L E F L A D K V V C T E S W P L A H H R T I Y T T F L L L F Q Y C L P L G F I L V C Y A R I Y R R L Q R Q G R V F H K R A G H M K Q V N V V L V V M V V A F A V L W L P L H V F N S L E D W H H E A I P I C H G N L I F L V C H L L A M A S T C V N P F I Y G F L N T N F K K E I K A L V L T C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X9C	A	Peptide	Neuropeptide Y	Y₄	Homo sapiens	Pancreatic Hormone	-	Gi1/β1/γ2	3	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9C (No Gprot)	A	Peptide	Neuropeptide Y	Y₄	Homo sapiens	Pancreatic Hormone	-		3	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1

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