psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D128	11.5	Yes	No	1	0	5
2	L:L:?1	R:R:Y129	17.22	Yes	No	0	0	5
3	L:L:?1	R:R:M132	11.18	Yes	No	0	0	8
4	L:L:?1	R:R:K214	2.39	Yes	No	1	0	5
5	L:L:?1	R:R:I277	4.03	Yes	No	0	0	5
6	L:L:?1	R:R:V281	3.37	Yes	No	1	0	6
7	L:L:?1	R:R:W284	7.08	Yes	No	0	0	4
8	L:L:?1	R:R:L300	10.17	Yes	No	1	0	5
9	L:L:?1	R:R:I304	8.06	Yes	Yes	1	0	5
10	L:L:?1	R:R:Y308	7.29	Yes	Yes	1	0	7
11	R:R:L46	R:R:S45	4.5	No	No	0	2	6
12	R:R:I52	R:R:L48	5.71	Yes	No	0	5	2
13	R:R:I50	R:R:T53	3.04	No	No	0	5	6
14	R:R:I52	R:R:L55	5.71	Yes	No	1	5	5
15	R:R:I52	R:R:Y56	15.71	Yes	Yes	1	5	7
16	R:R:I52	R:R:L302	4.28	Yes	No	0	5	5
17	R:R:A54	R:R:T53	1.68	No	No	0	5	6
18	R:R:L55	R:R:Y56	7.03	No	Yes	1	5	7
19	R:R:A305	R:R:L55	3.15	No	No	1	5	5
20	R:R:S106	R:R:Y56	2.54	No	Yes	0	6	7
21	R:R:H301	R:R:Y56	3.27	Yes	Yes	1	4	7
22	R:R:A305	R:R:Y56	5.34	No	Yes	1	5	7
23	R:R:A309	R:R:V59	1.7	No	No	7	5	7
24	R:R:S312	R:R:V59	3.23	Yes	No	7	7	7
25	R:R:C60	R:R:L102	9.52	No	No	1	6	7
26	R:R:C60	R:R:P103	3.77	No	No	1	6	8
27	R:R:G63	R:R:S312	1.86	No	Yes	0	8	7
28	R:R:L64	R:R:V68	2.98	No	No	0	6	4
29	R:R:L64	R:R:T99	10.32	No	No	0	6	6
30	R:R:G66	R:R:L65	1.71	No	No	0	7	4
31	R:R:N67	R:R:V70	2.96	Yes	No	0	9	8
32	R:R:D95	R:R:N67	13.46	Yes	Yes	3	9	9
33	R:R:A96	R:R:N67	3.13	No	Yes	0	7	9
34	R:R:N67	R:R:P315	4.89	Yes	No	3	9	9
35	R:R:L69	R:R:V68	5.96	No	No	0	6	4
36	R:R:I74	R:R:V70	3.07	No	No	0	7	8
37	R:R:M71	R:R:V75	3.04	Yes	No	0	7	3
38	R:R:F89	R:R:M71	3.73	No	Yes	2	6	7
39	R:R:A92	R:R:M71	4.83	No	Yes	0	9	7
40	R:R:L93	R:R:M71	4.24	No	Yes	2	6	7
41	R:R:F72	R:R:V75	2.62	No	No	0	4	3
42	R:R:I74	R:R:I88	11.77	No	No	5	7	8
43	R:R:F325	R:R:I74	6.28	Yes	No	5	8	7
44	R:R:K79	R:R:V75	4.55	No	No	0	5	3
45	R:R:R76	R:R:Y77	13.38	No	No	0	5	5
46	R:R:C328	R:R:Y77	12.1	No	No	0	6	5
47	R:R:K81	R:R:T78	9.01	No	No	0	6	6
48	R:R:N85	R:R:T78	14.62	No	No	0	8	6
49	R:R:K79	R:R:M80	11.52	No	No	0	5	7
50	R:R:T82	R:R:T84	3.14	No	No	0	7	8
51	R:R:N85	R:R:T82	10.24	No	No	0	8	7
52	R:R:A83	R:R:Y87	2.67	No	No	2	5	7
53	R:R:A165	R:R:A83	1.79	No	No	2	7	5
54	R:R:I86	R:R:K166	2.91	Yes	No	0	6	3
55	R:R:I86	R:R:N169	2.83	Yes	Yes	2	6	7
56	R:R:M141	R:R:Y87	7.18	No	No	2	7	7
57	R:R:I168	R:R:Y87	7.25	No	No	2	5	7
58	R:R:F325	R:R:I88	2.51	Yes	No	5	8	8
59	R:R:F89	R:R:N90	2.42	No	Yes	2	6	9
60	R:R:F89	R:R:L93	6.09	No	No	2	6	6
61	R:R:N90	R:R:T138	7.31	Yes	No	0	9	8
62	R:R:N169	R:R:N90	10.9	Yes	Yes	2	7	9
63	R:R:N90	R:R:W173	6.78	Yes	Yes	2	9	9
64	R:R:L91	R:R:T138	7.37	No	No	0	9	8
65	R:R:L93	R:R:W173	2.28	No	Yes	2	6	9
66	R:R:A94	R:R:T134	1.68	No	Yes	0	8	8
67	R:R:A94	R:R:S135	1.71	No	No	0	8	9
68	R:R:D95	R:R:S311	7.36	Yes	No	0	9	9
69	R:R:D95	R:R:P315	12.88	Yes	No	3	9	9
70	R:R:L97	R:R:N131	9.61	No	No	0	7	8
71	R:R:L97	R:R:W173	2.28	No	Yes	0	7	9
72	R:R:A98	R:R:S311	3.42	No	No	0	6	9
73	R:R:I127	R:R:T101	6.08	No	Yes	0	5	7
74	R:R:D128	R:R:T101	10.12	No	Yes	1	5	7
75	R:R:N131	R:R:T101	4.39	No	Yes	0	8	7
76	R:R:T101	R:R:Y308	6.24	Yes	Yes	1	7	7
77	R:R:L102	R:R:P103	8.21	No	No	1	7	8
78	R:R:L102	R:R:Y308	16.41	No	Yes	1	7	7
79	R:R:F104	R:R:L120	2.44	No	Yes	4	6	6
80	R:R:F104	R:R:V124	2.62	No	No	4	6	5
81	R:R:K108	R:R:Q105	4.07	No	No	0	4	5
82	R:R:A107	R:R:S106	1.71	No	No	0	3	6
83	R:R:H301	R:R:K108	2.62	Yes	No	0	4	4
84	R:R:V297	R:R:Y109	5.05	No	No	1	4	4
85	R:R:H301	R:R:Y109	25.04	Yes	No	1	4	4
86	R:R:L110	R:R:M111	5.65	No	No	0	4	4
87	R:R:A195	R:R:T113	1.68	No	No	0	2	4
88	R:R:P115	R:R:W114	4.05	No	Yes	0	3	8
89	R:R:F116	R:R:W114	2	Yes	Yes	0	7	8
90	R:R:C121	R:R:W114	3.92	No	Yes	4	9	8
91	R:R:V124	R:R:W114	7.36	No	Yes	4	5	8
92	R:R:C198	R:R:W114	3.92	No	Yes	4	9	8
93	R:R:F116	R:R:G117	6.02	Yes	No	0	7	7
94	R:R:F116	R:R:L119	2.44	Yes	No	0	7	3
95	R:R:F116	R:R:L120	23.14	Yes	Yes	0	7	6
96	R:R:E118	R:R:G117	1.64	No	No	0	4	7
97	R:R:E118	R:R:T189	9.88	No	No	0	4	4
98	R:R:K122	R:R:L119	7.05	No	No	0	7	3
99	R:R:L120	R:R:V124	4.47	Yes	No	4	6	5
100	R:R:C121	R:R:T189	3.38	No	No	0	9	4
101	R:R:C121	R:R:C198	7.28	No	No	4	9	9
102	R:R:C198	R:R:L125	6.35	No	No	0	9	5
103	R:R:M184	R:R:S126	10.73	No	No	0	4	6
104	R:R:D128	R:R:Y308	10.34	No	Yes	1	5	7
105	R:R:I183	R:R:Y129	3.63	No	No	0	4	5
106	R:R:N131	R:R:Y130	2.33	No	Yes	0	8	5
107	R:R:T134	R:R:Y130	7.49	Yes	Yes	2	8	5
108	R:R:W173	R:R:Y130	4.82	Yes	Yes	2	9	5
109	R:R:A176	R:R:Y130	2.67	No	Yes	2	8	5
110	R:R:S177	R:R:Y130	6.36	No	Yes	0	4	5
111	R:R:M132	R:R:W274	3.49	No	Yes	0	8	8
112	R:R:F133	R:R:V179	9.18	No	No	0	7	4
113	R:R:T134	R:R:W173	3.64	Yes	Yes	2	8	9
114	R:R:A176	R:R:T134	1.68	No	Yes	2	8	8
115	R:R:S135	R:R:W274	2.47	No	Yes	0	9	8
116	R:R:I136	R:R:P225	3.39	Yes	Yes	0	7	8
117	R:R:F270	R:R:I136	3.77	No	Yes	3	9	7
118	R:R:I136	R:R:W274	7.05	Yes	Yes	3	7	8
119	R:R:I229	R:R:L139	4.28	Yes	No	0	8	8
120	R:R:L139	R:R:Y318	5.86	No	No	0	8	9
121	R:R:P225	R:R:T140	1.75	Yes	No	0	8	7
122	R:R:I228	R:R:T140	4.56	No	No	0	7	7
123	R:R:I168	R:R:M141	7.29	No	No	2	5	7
124	R:R:I172	R:R:M141	2.92	Yes	No	2	6	7
125	R:R:M142	R:R:Y318	5.99	No	No	0	9	9
126	R:R:I229	R:R:S143	7.74	Yes	No	6	8	9
127	R:R:S143	R:R:Y233	6.36	No	Yes	6	9	8
128	R:R:I148	R:R:V144	3.07	No	No	0	5	7
129	R:R:C232	R:R:V144	1.71	No	No	0	8	7
130	R:R:D145	R:R:R160	10.72	No	No	0	8	6
131	R:R:R146	R:R:Y233	8.23	No	Yes	6	9	8
132	R:R:M236	R:R:R146	4.96	Yes	No	6	8	9
133	R:R:M262	R:R:R146	3.72	No	No	0	8	9
134	R:R:I148	R:R:Y147	2.42	No	Yes	0	5	8
135	R:R:C151	R:R:Y147	9.41	No	Yes	0	7	8
136	R:R:H152	R:R:Y147	7.62	No	Yes	0	6	8
137	R:R:L235	R:R:Y147	5.86	No	Yes	0	4	8
138	R:R:A149	R:R:R160	5.53	No	No	0	8	6
139	R:R:C151	R:R:V150	3.42	No	No	0	7	8
140	R:R:M236	R:R:V150	6.09	Yes	No	0	8	8
141	R:R:P162	R:R:T161	3.5	No	No	0	3	7
142	R:R:A163	R:R:T161	1.68	No	No	0	4	7
143	R:R:K164	R:R:T161	3	No	No	0	4	7
144	R:R:I168	R:R:I172	2.94	No	Yes	2	5	6
145	R:R:I170	R:R:N169	7.08	No	Yes	0	4	7
146	R:R:N169	R:R:W173	4.52	Yes	Yes	2	7	9
147	R:R:C171	R:R:I172	1.64	No	Yes	0	3	6
148	R:R:C171	R:R:V174	1.71	No	No	0	3	4
149	R:R:G178	R:R:S177	3.71	No	No	0	3	4
150	R:R:G178	R:R:V181	1.84	No	No	0	3	4
151	R:R:G180	R:R:P182	2.03	No	No	0	7	7
152	R:R:P182	R:R:V181	5.3	No	No	0	7	4
153	R:R:M186	R:R:V185	6.09	No	No	0	4	4
154	R:R:Q201	R:R:V188	12.89	No	No	0	4	4
155	R:R:P191	R:R:R190	2.88	No	No	0	1	3
156	R:R:R190	R:R:R192	2.13	No	No	8	3	1
157	R:R:D193	R:R:R192	8.34	No	No	0	1	1
158	R:R:M199	R:R:V197	10.65	No	No	0	4	4
159	R:R:F202	R:R:P203	2.89	Yes	No	0	6	6
160	R:R:F202	R:R:S204	2.64	Yes	Yes	9	6	4
161	R:R:D210	R:R:F202	11.94	No	Yes	9	4	6
162	R:R:F202	R:R:T213	9.08	Yes	No	0	6	6
163	R:R:P205	R:R:S204	3.56	No	Yes	0	2	4
164	R:R:S204	R:R:W209	6.18	Yes	No	0	4	4
165	R:R:D210	R:R:S204	10.31	No	Yes	9	4	4
166	R:R:P205	R:R:Y208	4.17	No	No	0	2	3
167	R:R:D210	R:R:S206	4.42	No	No	0	4	3
168	R:R:W207	R:R:Y208	20.26	No	No	0	3	3
169	R:R:C216	R:R:V212	1.71	No	No	0	3	4
170	R:R:K214	R:R:V281	9.11	No	No	1	5	6
171	R:R:A221	R:R:V217	1.7	No	No	0	6	5
172	R:R:F218	R:R:H278	6.79	No	No	0	5	7
173	R:R:F220	R:R:L219	6.09	No	No	0	4	4
174	R:R:L219	R:R:V223	8.94	No	No	0	4	4
175	R:R:F222	R:R:I226	8.79	No	Yes	0	8	6
176	R:R:A275	R:R:F222	2.77	No	No	0	6	8
177	R:R:F222	R:R:H278	10.18	No	No	0	8	7
178	R:R:L227	R:R:V223	2.98	No	No	0	4	4
179	R:R:P225	R:R:V224	3.53	Yes	No	0	8	5
180	R:R:L227	R:R:V224	7.45	No	No	0	4	5
181	R:R:I226	R:R:P225	1.69	Yes	Yes	0	6	8
182	R:R:F270	R:R:I226	5.02	No	Yes	0	9	6
183	R:R:C232	R:R:I228	1.64	No	No	0	8	7
184	R:R:I229	R:R:Y233	3.63	Yes	Yes	6	8	8
185	R:R:C232	R:R:V231	1.71	No	No	0	8	4
186	R:R:M236	R:R:Y233	2.39	Yes	Yes	6	8	8
187	R:R:V263	R:R:Y233	2.52	Yes	Yes	0	7	8
188	R:R:L237	R:R:M236	5.65	No	Yes	0	5	8
189	R:R:L237	R:R:V263	7.45	No	Yes	0	5	7
190	R:R:R239	R:R:S242	2.64	No	No	0	5	4
191	R:R:R239	R:R:V243	3.92	No	No	0	5	6
192	R:R:L240	R:R:L246	9.69	No	Yes	10	8	2
193	R:R:I259	R:R:L240	2.85	No	No	10	8	8
194	R:R:L245	R:R:V243	4.47	No	No	0	3	6
195	R:R:L246	R:R:L256	2.77	Yes	Yes	0	2	6
196	R:R:I259	R:R:L246	7.14	No	Yes	10	8	2
197	R:R:G248	R:R:S247	3.71	No	No	0	2	3
198	R:R:E251	R:R:S249	5.75	No	No	0	3	2
199	R:R:E251	R:R:K252	14.85	No	No	0	3	2
200	R:R:K252	R:R:R254	4.95	No	No	0	2	4
201	R:R:D253	R:R:L256	6.79	No	Yes	0	2	6
202	R:R:L256	R:R:T260	2.95	Yes	No	0	6	7
203	R:R:R257	R:R:T260	7.76	No	No	0	5	7
204	R:R:R257	R:R:R261	2.13	No	No	0	5	6
205	R:R:M262	R:R:V263	3.04	No	Yes	0	8	7
206	R:R:V266	R:R:Y318	7.57	No	No	0	7	9
207	R:R:G268	R:R:V267	1.84	No	No	0	5	7
208	R:R:G268	R:R:V271	3.68	No	No	0	5	6
209	R:R:F270	R:R:W274	13.03	No	Yes	3	9	8
210	R:R:C273	R:R:N310	6.3	No	Yes	0	8	9
211	R:R:H278	R:R:W274	4.23	No	Yes	0	7	8
212	R:R:N310	R:R:W274	33.9	Yes	Yes	3	9	8
213	R:R:N314	R:R:W274	10.17	No	Yes	3	9	8
214	R:R:A275	R:R:P276	3.74	No	No	0	6	9
215	R:R:C303	R:R:I277	1.64	No	No	0	6	5
216	R:R:G307	R:R:I277	1.76	No	No	0	7	5
217	R:R:C303	R:R:F280	4.19	No	No	0	6	5
218	R:R:I282	R:R:T285	3.04	No	No	0	6	4
219	R:R:I282	R:R:L286	2.85	No	No	0	6	4
220	R:R:V283	R:R:V287	4.81	No	No	0	4	3
221	R:R:R291	R:R:W284	3	No	No	0	1	4
222	R:R:D290	R:R:I289	8.4	No	No	0	3	1
223	R:R:D290	R:R:D293	2.66	No	No	0	3	3
224	R:R:R291	R:R:R292	6.4	No	No	0	1	1
225	R:R:D293	R:R:P294	3.22	No	No	0	3	2
226	R:R:D293	R:R:V296	2.92	No	No	0	3	5
227	R:R:L295	R:R:P294	4.93	No	No	0	2	2
228	R:R:H301	R:R:V297	5.54	Yes	No	1	4	4
229	R:R:A299	R:R:L302	3.15	No	No	0	5	5
230	R:R:H301	R:R:L300	2.57	Yes	No	1	4	5
231	R:R:I304	R:R:L300	7.14	Yes	No	1	5	5
232	R:R:H301	R:R:I304	2.65	Yes	Yes	1	4	5
233	R:R:C303	R:R:I304	1.64	No	Yes	0	6	5
234	R:R:A309	R:R:L306	3.15	No	No	0	5	7
235	R:R:G307	R:R:N310	3.39	No	Yes	0	7	9
236	R:R:A309	R:R:S312	1.71	No	Yes	7	5	7
237	R:R:N310	R:R:N314	9.54	Yes	No	3	9	9
238	R:R:L313	R:R:S312	6.01	No	Yes	0	7	7
239	R:R:L313	R:R:V316	7.45	No	No	0	7	6
240	R:R:L313	R:R:L317	4.15	No	No	0	7	8
241	R:R:N314	R:R:P315	4.89	No	No	3	9	9
242	R:R:F320	R:R:L321	8.53	No	No	0	7	6
243	R:R:D322	R:R:N324	12.12	No	No	5	8	7
244	R:R:D322	R:R:F325	14.33	No	Yes	5	8	8
245	R:R:E323	R:R:N324	3.94	No	No	0	4	7
246	R:R:F325	R:R:N324	6.04	Yes	No	5	8	7
247	R:R:S311	R:R:S312	1.63	No	Yes	0	9	7
248	R:R:A83	R:R:I86	1.62	No	Yes	2	5	6
249	R:R:A165	R:R:I86	1.62	No	Yes	2	7	6
250	R:R:A187	R:R:K122	1.61	No	No	0	4	7
251	R:R:S100	R:R:T101	1.6	No	Yes	0	5	7
252	R:R:V265	R:R:V266	1.6	No	No	0	6	7
253	R:R:V296	R:R:V297	1.6	No	No	0	5	4
254	R:R:C171	R:R:L175	1.59	No	No	0	3	5
255	R:R:A51	R:R:L48	1.58	No	No	0	4	2
256	R:R:A298	R:R:L48	1.58	No	No	0	1	2
257	R:R:A107	R:R:L110	1.58	No	No	0	3	4
258	R:R:A123	R:R:L120	1.58	No	Yes	0	4	6
259	R:R:A298	R:R:L302	1.58	No	No	0	1	5
260	R:R:I215	R:R:V212	1.54	No	No	0	4	4
261	R:R:I259	R:R:V263	1.54	No	Yes	0	8	7
262	R:R:H152	R:R:P153	1.53	No	No	0	6	8
263	R:R:I226	R:R:T230	1.52	Yes	No	0	6	4
264	R:R:I229	R:R:T230	1.52	Yes	No	0	8	4
265	R:R:F72	R:R:G73	1.51	No	No	0	4	8
266	R:R:M111	R:R:T113	1.51	No	No	0	4	4
267	R:R:K214	R:R:T285	1.5	No	No	0	5	4
268	R:R:L246	R:R:S255	1.5	Yes	No	0	2	5
269	R:R:L240	R:R:V243	1.49	No	No	0	8	6
270	R:R:D322	R:R:T84	1.45	No	No	0	8	8
271	R:R:D95	R:R:T99	1.45	Yes	No	0	9	6
272	R:R:I183	R:R:L200	1.43	No	No	0	4	4
273	R:R:A176	R:R:F133	1.39	No	No	0	8	7
274	R:R:L125	R:R:L200	1.38	No	No	0	5	4
275	R:R:D158	R:R:K155	1.38	No	No	0	4	5
276	R:R:D253	R:R:K250	1.38	No	No	0	2	2
277	R:R:R254	R:R:S255	1.32	No	No	0	4	5
278	R:R:F133	R:R:V217	1.31	No	No	0	7	5
279	R:R:R190	R:R:V197	1.31	No	No	8	3	4
280	R:R:R192	R:R:V197	1.31	No	No	8	1	4
281	R:R:F137	R:R:I136	1.26	No	Yes	0	6	7
282	R:R:F137	R:R:I172	1.26	No	Yes	0	6	6
283	R:R:V196	R:R:W114	1.23	No	Yes	0	4	8
284	R:R:L238	R:R:R239	1.21	No	No	0	4	5
285	R:R:L256	R:R:R241	1.21	Yes	No	0	6	4
286	R:R:D145	R:R:F159	1.19	No	No	0	8	3
287	R:R:D158	R:R:F159	1.19	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.229	10	1	0
2	R:R:I52	7.8525	4	1	5
3	R:R:Y56	6.778	5	1	7
4	R:R:N67	6.11	4	3	9
5	R:R:M71	3.96	4	2	7
6	R:R:I86	2.245	4	2	6
7	R:R:N90	6.8525	4	2	9
8	R:R:D95	8.7875	4	3	9
9	R:R:T101	5.686	5	1	7
10	R:R:W114	3.74667	6	4	8
11	R:R:F116	8.4	4	0	7
12	R:R:L120	7.9075	4	4	6
13	R:R:Y130	4.734	5	2	5
14	R:R:T134	3.6225	4	2	8
15	R:R:I136	3.8675	4	3	7
16	R:R:Y147	6.3275	4	0	8
17	R:R:N169	6.3325	4	2	7
18	R:R:I172	2.19	4	2	6
19	R:R:W173	4.05333	6	2	9
20	R:R:F202	6.6375	4	9	6
21	R:R:S204	5.6725	4	9	4
22	R:R:P225	2.59	4	0	8
23	R:R:I226	4.255	4	0	6
24	R:R:I229	4.2925	4	6	8
25	R:R:Y233	4.626	5	6	8
26	R:R:M236	4.7725	4	6	8
27	R:R:L246	5.275	4	10	2
28	R:R:L256	3.43	4	0	6
29	R:R:V263	3.6375	4	0	7
30	R:R:W274	10.62	7	3	8
31	R:R:H301	6.94833	6	1	4
32	R:R:I304	4.8725	4	1	5
33	R:R:Y308	10.07	4	1	7
34	R:R:N310	13.2825	4	3	9
35	R:R:S312	2.888	5	7	7
36	R:R:F325	7.29	4	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L300	64.7931	10.17	Yes	No	1	0	5
2	R:R:H301	R:R:L300	62.8929	2.57	Yes	No	1	4	5
3	R:R:H301	R:R:Y56	77.7304	3.27	Yes	Yes	1	4	7
4	R:R:I52	R:R:Y56	34.6031	15.71	Yes	Yes	1	5	7
5	L:L:?1	R:R:I304	69.1529	8.06	Yes	Yes	1	0	5
6	R:R:H301	R:R:I304	64.58	2.65	Yes	Yes	1	4	5
7	R:R:I52	R:R:L48	14.9352	5.71	Yes	No	0	5	2
8	R:R:I52	R:R:L302	14.9441	4.28	Yes	No	0	5	5
9	R:R:S106	R:R:Y56	29.7727	2.54	No	Yes	0	6	7
10	L:L:?1	R:R:M132	99.6448	11.18	Yes	No	0	0	8
11	R:R:M132	R:R:W274	100	3.49	No	Yes	0	8	8
12	R:R:N314	R:R:W274	57.9293	10.17	No	Yes	3	9	8
13	R:R:N314	R:R:P315	57.9116	4.89	No	No	3	9	9
14	R:R:D95	R:R:P315	29.2932	12.88	Yes	No	3	9	9
15	R:R:D95	R:R:S311	21.2129	7.36	Yes	No	0	9	9
16	R:R:S311	R:R:S312	17.1106	1.63	No	Yes	0	9	7
17	L:L:?1	R:R:Y308	57.5919	7.29	Yes	Yes	1	0	7
18	R:R:N67	R:R:P315	26.9224	4.89	Yes	No	3	9	9
19	R:R:N67	R:R:V70	24.8269	2.96	Yes	No	0	9	8
20	R:R:I74	R:R:V70	22.8201	3.07	No	No	0	7	8
21	L:L:?1	R:R:D128	52.0068	11.5	Yes	No	1	0	5
22	R:R:D128	R:R:T101	50.8791	10.12	No	Yes	1	5	7
23	R:R:N131	R:R:T101	94.3704	4.39	No	Yes	0	8	7
24	R:R:L97	R:R:N131	36.3346	9.61	No	No	0	7	8
25	R:R:L97	R:R:W173	35.7929	2.28	No	Yes	0	7	9
26	R:R:L93	R:R:W173	41.6622	2.28	No	Yes	2	6	9
27	R:R:L93	R:R:M71	32.5608	4.24	No	Yes	2	6	7
28	R:R:T101	R:R:Y308	52.6194	6.24	Yes	Yes	1	7	7
29	R:R:N131	R:R:Y130	56.2334	2.33	No	Yes	0	8	5
30	R:R:W173	R:R:Y130	37.258	4.82	Yes	Yes	2	9	5
31	R:R:M71	R:R:V75	24.2763	3.04	Yes	No	0	7	3
32	R:R:N90	R:R:W173	17.9897	6.78	Yes	Yes	2	9	9
33	R:R:F325	R:R:I74	18.6645	6.28	Yes	No	5	8	7
34	R:R:D322	R:R:F325	12.6088	14.33	No	Yes	5	8	8
35	R:R:D322	R:R:T84	10.602	1.45	No	No	0	8	8
36	R:R:N169	R:R:W173	27.9524	4.52	Yes	Yes	2	7	9
37	R:R:I86	R:R:N169	20.6802	2.83	Yes	Yes	2	6	7
38	R:R:A83	R:R:I86	11.1703	1.62	No	Yes	2	5	6
39	R:R:I136	R:R:W274	42.6123	7.05	Yes	Yes	3	7	8
40	R:R:F137	R:R:I136	31.0513	1.26	No	Yes	0	6	7
41	R:R:F137	R:R:I172	28.796	1.26	No	Yes	0	6	6
42	R:R:I172	R:R:M141	10.9483	2.92	Yes	No	2	6	7
43	R:R:A83	R:R:Y87	14.3847	2.67	No	No	2	5	7
44	R:R:I168	R:R:I172	10.9483	2.94	No	Yes	2	5	6
45	R:R:S135	R:R:W274	33.1291	2.47	No	Yes	0	9	8
46	R:R:A94	R:R:S135	31.5752	1.71	No	No	0	8	9
47	R:R:A94	R:R:T134	30.1279	1.68	No	Yes	0	8	8
48	L:L:?1	R:R:Y129	58.3555	17.22	Yes	No	0	0	5
49	R:R:I183	R:R:Y129	55.9847	3.63	No	No	0	4	5
50	R:R:I183	R:R:L200	53.7027	1.43	No	No	0	4	4
51	R:R:L125	R:R:L200	51.1543	1.38	No	No	0	5	4
52	R:R:C198	R:R:L125	48.5793	6.35	No	No	0	9	5
53	R:R:C198	R:R:W114	37.7908	3.92	No	Yes	4	9	8
54	R:R:F116	R:R:W114	19.517	2	Yes	Yes	0	7	8
55	R:R:V124	R:R:W114	10.9128	7.36	No	Yes	4	5	8
56	R:R:A107	R:R:S106	24.8535	1.71	No	No	0	3	6
57	R:R:H301	R:R:V297	34.1769	5.54	Yes	No	1	4	4
58	R:R:A107	R:R:L110	19.9165	1.58	No	No	0	3	4
59	R:R:L110	R:R:M111	14.9618	5.65	No	No	0	4	4
60	R:R:S177	R:R:Y130	15.1749	6.36	No	Yes	0	4	5
61	R:R:A176	R:R:F133	12.4578	1.39	No	No	0	8	7
62	R:R:I136	R:R:P225	34.7452	3.39	Yes	Yes	0	7	8
63	R:R:F270	R:R:W274	61.6764	13.03	No	Yes	3	9	8
64	R:R:F270	R:R:I226	67.235	5.02	No	Yes	0	9	6
65	R:R:I226	R:R:T230	76.4518	1.52	Yes	No	0	6	4
66	R:R:I229	R:R:T230	74.7558	1.52	Yes	No	0	8	4
67	R:R:I229	R:R:L139	11.7919	4.28	Yes	No	0	8	8
68	R:R:P225	R:R:T140	20.103	1.75	Yes	No	0	8	7
69	R:R:I228	R:R:T140	18.0075	4.56	No	No	0	7	7
70	R:R:I229	R:R:Y233	62.3069	3.63	Yes	Yes	6	8	8
71	R:R:C232	R:R:I228	15.9208	1.64	No	No	0	8	7
72	R:R:C232	R:R:V144	12.5999	1.71	No	No	0	8	7
73	R:R:I148	R:R:V144	11.1792	3.07	No	No	0	5	7
74	R:R:M236	R:R:Y233	10.9838	2.39	Yes	Yes	6	8	8
75	R:R:V263	R:R:Y233	50.1509	2.52	Yes	Yes	0	7	8
76	R:R:G178	R:R:S177	12.1737	3.71	No	No	0	3	4
77	R:R:P225	R:R:V224	11.268	3.53	Yes	No	0	8	5
78	R:R:I259	R:R:V263	46.466	1.54	No	Yes	0	8	7
79	R:R:I259	R:R:L240	14.0295	2.85	No	No	10	8	8
80	R:R:L240	R:R:V243	12.5111	1.49	No	No	0	8	6
81	R:R:I259	R:R:L246	30.4653	7.14	No	Yes	10	8	2
82	R:R:L246	R:R:L256	17.1728	2.77	Yes	Yes	0	2	6
83	R:R:L246	R:R:S255	12.5111	1.5	Yes	No	0	2	5
84	R:R:R254	R:R:S255	10.0426	1.32	No	No	0	4	5
85	L:L:?1	R:R:K214	10.8329	2.39	Yes	No	1	0	5
86	R:R:V296	R:R:V297	29.3287	1.6	No	No	0	5	4
87	R:R:D293	R:R:V296	24.4095	2.92	No	No	0	3	5
88	R:R:T134	R:R:W173	18.3626	3.64	Yes	Yes	2	8	9
89	R:R:I226	R:R:P225	10.8684	1.69	Yes	Yes	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D128	11.5	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y129	17.22	1	Yes	No	0	5	0	1
L:L:?1	R:R:M132	11.18	1	Yes	No	0	8	0	1
L:L:?1	R:R:K214	2.39	1	Yes	No	0	5	0	1
L:L:?1	R:R:I277	4.03	1	Yes	No	0	5	0	1
L:L:?1	R:R:V281	3.37	1	Yes	No	0	6	0	1
L:L:?1	R:R:W284	7.08	1	Yes	No	0	4	0	1
L:L:?1	R:R:L300	10.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:I304	8.06	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y308	7.29	1	Yes	Yes	0	7	0	1
R:R:D128	R:R:T101	10.12	1	No	Yes	5	7	1	2
R:R:T101	R:R:Y308	6.24	1	Yes	Yes	7	7	2	1
R:R:L102	R:R:Y308	16.41	1	No	Yes	7	7	2	1
R:R:D128	R:R:Y308	10.34	1	No	Yes	5	7	1	1
R:R:I183	R:R:Y129	3.63	0	No	No	4	5	2	1
R:R:M132	R:R:W274	3.49	0	No	Yes	8	8	1	2
R:R:K214	R:R:V281	9.11	1	No	No	5	6	1	1
R:R:C303	R:R:I277	1.64	0	No	No	6	5	2	1
R:R:G307	R:R:I277	1.76	0	No	No	7	5	2	1
R:R:R291	R:R:W284	3	0	No	No	1	4	2	1
R:R:H301	R:R:L300	2.57	1	Yes	No	4	5	2	1
R:R:I304	R:R:L300	7.14	1	Yes	No	5	5	1	1
R:R:H301	R:R:I304	2.65	1	Yes	Yes	4	5	2	1
R:R:C303	R:R:I304	1.64	0	No	Yes	6	5	2	1
R:R:K214	R:R:T285	1.5	1	No	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y45_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.64
Number of Linked Nodes	261
Number of Links	287
Number of Hubs	36
Number of Links mediated by Hubs	139
Number of Communities	10
Number of Nodes involved in Communities	70
Number of Links involved in Communities	90

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	37965
Length Of Smallest Path	3
Average Path Length	12.1861
Length of Longest Path	26
Minimum Path Strength	1.19
Average Path Strength	5.20293
Maximum Path Strength	23.465
Minimum Path Correlation	0.7
Average Path Correlation	0.932638
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	52.0846
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3755
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G protein-coupled enkephalin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • neuropeptide binding • peptide binding • receptor serine/threonine kinase binding • neuropeptide signaling pathway • adult locomotory behavior • behavior • adult behavior • locomotory behavior • immune response • immune system process • regulation of mitochondrial membrane potential • regulation of membrane potential • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • G protein-coupled opioid receptor signaling pathway • eating behavior • feeding behavior • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • response to ethanol • cellular response to growth factor stimulus • response to growth factor • cellular response to toxic substance • response to toxic substance • regulation of biosynthetic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of macromolecule metabolic process • response to nicotine • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • postsynapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • presynapse • presynaptic membrane • cell leading edge • leading edge membrane • neuron projection membrane • dendrite membrane • cell projection membrane • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus • neuron spine • dendritic spine • spine apparatus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>8Y45_nogp_Chain_R S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P R D G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5

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