psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A98	4.72	Yes	No	0	0	6
2	L:L:?1	R:R:D128	11.17	Yes	Yes	1	0	5
3	L:L:?1	R:R:Y129	10.53	Yes	No	0	0	5
4	L:L:?1	R:R:M132	5.29	Yes	No	1	0	8
5	L:L:?1	R:R:S135	4.49	Yes	No	0	0	9
6	L:L:?1	R:R:W274	11.08	Yes	Yes	1	0	8
7	L:L:?1	R:R:I277	6.41	Yes	No	0	0	5
8	L:L:?1	R:R:H278	7.7	Yes	Yes	1	0	7
9	L:L:?1	R:R:V281	16.72	Yes	No	0	0	6
10	L:L:?1	R:R:W284	6.82	Yes	No	0	0	4
11	L:L:?1	R:R:L300	3.11	Yes	No	0	0	5
12	L:L:?1	R:R:I304	7.48	Yes	No	0	0	5
13	L:L:?1	R:R:Y308	7.02	Yes	No	1	0	7
14	L:L:?1	R:R:N310	4.11	Yes	Yes	1	0	9
15	L:L:?1	R:R:S311	4.49	Yes	No	0	0	9
16	R:R:A298	R:R:L48	4.73	No	No	0	1	2
17	R:R:I52	R:R:Y56	3.63	No	Yes	0	5	7
18	R:R:I52	R:R:Y109	4.84	No	Yes	0	5	4
19	R:R:L110	R:R:T53	11.79	No	No	0	4	6
20	R:R:L55	R:R:V59	2.98	No	Yes	0	5	7
21	R:R:A305	R:R:L55	4.73	No	No	0	5	5
22	R:R:L102	R:R:Y56	11.72	Yes	Yes	0	7	7
23	R:R:S106	R:R:Y56	5.09	No	Yes	0	6	7
24	R:R:H301	R:R:Y56	10.89	No	Yes	0	4	7
25	R:R:I304	R:R:Y56	4.84	No	Yes	0	5	7
26	R:R:A305	R:R:Y56	2.67	No	Yes	0	5	7
27	R:R:L102	R:R:V59	2.98	Yes	Yes	0	7	7
28	R:R:S312	R:R:V59	4.85	No	Yes	0	7	7
29	R:R:S312	R:R:V62	4.85	No	No	0	7	4
30	R:R:G63	R:R:S312	3.71	No	No	0	8	7
31	R:R:L64	R:R:T99	2.95	No	No	0	6	6
32	R:R:L65	R:R:V68	2.98	No	No	0	4	4
33	R:R:L65	R:R:L69	5.54	No	No	0	4	6
34	R:R:G66	R:R:L69	3.42	No	No	0	7	6
35	R:R:G66	R:R:P315	4.06	No	No	0	7	9
36	R:R:D95	R:R:N67	4.04	Yes	No	3	9	9
37	R:R:A96	R:R:N67	4.69	No	No	0	7	9
38	R:R:N67	R:R:P315	6.52	No	No	3	9	9
39	R:R:I74	R:R:V70	3.07	No	No	0	7	8
40	R:R:A92	R:R:V70	3.39	No	No	0	9	8
41	R:R:V70	R:R:Y318	7.57	No	Yes	0	8	9
42	R:R:F89	R:R:M71	4.98	No	No	5	6	7
43	R:R:A92	R:R:M71	3.22	No	No	0	9	7
44	R:R:L93	R:R:M71	2.83	No	No	5	6	7
45	R:R:R76	R:R:Y77	5.14	No	No	0	5	5
46	R:R:N85	R:R:T78	5.85	No	No	0	8	6
47	R:R:F89	R:R:M80	4.98	No	No	0	6	7
48	R:R:T82	R:R:T84	3.14	No	No	0	7	8
49	R:R:I88	R:R:T84	3.04	No	No	0	8	8
50	R:R:I86	R:R:K166	5.82	Yes	No	0	6	3
51	R:R:I86	R:R:N169	4.25	Yes	No	0	6	7
52	R:R:M141	R:R:Y87	8.38	No	Yes	6	7	7
53	R:R:M142	R:R:Y87	4.79	No	Yes	0	9	7
54	R:R:D145	R:R:Y87	4.6	No	Yes	0	8	7
55	R:R:I168	R:R:Y87	4.84	No	Yes	6	5	7
56	R:R:N169	R:R:Y87	11.63	No	Yes	0	7	7
57	R:R:I88	R:R:M142	2.92	No	No	0	8	9
58	R:R:I88	R:R:Y318	14.51	No	Yes	0	8	9
59	R:R:F89	R:R:L93	4.87	No	No	5	6	6
60	R:R:N90	R:R:T138	4.39	No	No	0	9	8
61	R:R:N169	R:R:N90	12.26	No	No	0	7	9
62	R:R:N90	R:R:W173	11.3	No	No	0	9	9
63	R:R:D95	R:R:L91	4.07	Yes	Yes	0	9	9
64	R:R:L91	R:R:S135	3	Yes	No	0	9	9
65	R:R:L91	R:R:T138	7.37	Yes	No	0	9	8
66	R:R:L139	R:R:L91	4.15	No	Yes	0	8	9
67	R:R:A94	R:R:S135	3.42	No	No	0	8	9
68	R:R:D95	R:R:S311	11.78	Yes	No	0	9	9
69	R:R:D95	R:R:N314	5.39	Yes	No	0	9	9
70	R:R:D95	R:R:P315	3.22	Yes	No	3	9	9
71	R:R:L97	R:R:N131	13.73	No	No	0	7	8
72	R:R:A98	R:R:N131	6.25	No	No	0	6	8
73	R:R:S311	R:R:T99	3.2	No	No	0	9	6
74	R:R:I127	R:R:T101	6.08	No	No	0	5	7
75	R:R:D128	R:R:T101	4.34	Yes	No	0	5	7
76	R:R:L102	R:R:P103	3.28	Yes	No	0	7	8
77	R:R:L102	R:R:Y308	23.45	Yes	No	0	7	7
78	R:R:F104	R:R:F116	4.29	No	Yes	2	6	7
79	R:R:F104	R:R:L120	8.53	No	No	2	6	6
80	R:R:K108	R:R:Q105	12.2	No	No	0	4	5
81	R:R:D128	R:R:Q105	5.22	Yes	No	0	5	5
82	R:R:I304	R:R:Q105	2.74	No	No	0	5	5
83	R:R:K108	R:R:W114	6.96	No	Yes	0	4	8
84	R:R:H301	R:R:K108	3.93	No	No	0	4	4
85	R:R:V297	R:R:Y109	3.79	No	Yes	0	4	4
86	R:R:H301	R:R:Y109	22.87	No	Yes	0	4	4
87	R:R:M111	R:R:T113	3.01	No	No	2	4	4
88	R:R:M111	R:R:P115	3.35	No	No	2	4	3
89	R:R:P115	R:R:T113	3.5	No	No	2	3	4
90	R:R:F116	R:R:W114	15.03	Yes	Yes	2	7	8
91	R:R:C121	R:R:W114	9.14	No	Yes	2	9	8
92	R:R:V196	R:R:W114	4.9	No	Yes	0	4	8
93	R:R:C198	R:R:W114	11.75	No	Yes	2	9	8
94	R:R:F116	R:R:P115	15.89	Yes	No	2	7	3
95	R:R:F116	R:R:L120	7.31	Yes	No	2	7	6
96	R:R:E118	R:R:V188	8.56	No	No	0	4	4
97	R:R:E118	R:R:T189	4.23	No	Yes	0	4	4
98	R:R:C121	R:R:T189	3.38	No	Yes	2	9	4
99	R:R:C121	R:R:C198	5.46	No	No	2	9	9
100	R:R:K122	R:R:M184	11.52	No	No	0	7	4
101	R:R:I183	R:R:S126	3.1	No	No	0	4	6
102	R:R:M184	R:R:S126	4.6	No	No	0	4	6
103	R:R:D128	R:R:Y308	4.6	Yes	No	1	5	7
104	R:R:I183	R:R:Y129	14.51	No	No	0	4	5
105	R:R:T134	R:R:Y130	3.75	No	Yes	7	8	5
106	R:R:W173	R:R:Y130	10.61	No	Yes	7	9	5
107	R:R:A176	R:R:Y130	2.67	No	Yes	0	8	5
108	R:R:S177	R:R:Y130	3.82	No	Yes	0	4	5
109	R:R:M132	R:R:W274	6.98	No	Yes	1	8	8
110	R:R:F133	R:R:F137	5.36	No	No	0	7	6
111	R:R:A221	R:R:F133	4.16	No	No	0	6	7
112	R:R:T134	R:R:W173	10.92	No	No	7	8	9
113	R:R:I136	R:R:P225	3.39	No	No	0	7	8
114	R:R:F137	R:R:I172	3.77	No	No	0	6	6
115	R:R:L139	R:R:N314	4.12	No	No	0	8	9
116	R:R:P225	R:R:T140	3.5	No	No	0	8	7
117	R:R:I228	R:R:T140	4.56	No	No	0	7	7
118	R:R:I168	R:R:M141	2.92	No	No	6	5	7
119	R:R:I172	R:R:M141	4.37	No	No	0	6	7
120	R:R:I229	R:R:S143	7.74	No	No	0	8	9
121	R:R:C232	R:R:S143	5.16	Yes	No	0	8	9
122	R:R:S143	R:R:Y233	10.17	No	No	0	9	8
123	R:R:D145	R:R:R160	14.29	No	No	0	8	6
124	R:R:R146	R:R:Y233	9.26	No	No	0	9	8
125	R:R:C151	R:R:Y147	6.72	No	Yes	8	7	8
126	R:R:H152	R:R:Y147	9.8	No	Yes	8	6	8
127	R:R:C232	R:R:Y147	6.72	Yes	Yes	0	8	8
128	R:R:L235	R:R:Y147	8.21	No	Yes	0	4	8
129	R:R:A149	R:R:R160	5.53	No	No	0	8	6
130	R:R:M236	R:R:V150	6.09	No	No	0	8	8
131	R:R:R239	R:R:V150	2.62	Yes	No	0	5	8
132	R:R:L240	R:R:V150	4.47	No	No	0	8	8
133	R:R:C151	R:R:H152	4.42	No	No	8	7	6
134	R:R:C151	R:R:R239	2.79	No	Yes	0	7	5
135	R:R:A156	R:R:R160	2.77	No	No	0	5	6
136	R:R:P162	R:R:T161	3.5	No	No	0	3	7
137	R:R:K164	R:R:T161	6.01	No	No	0	4	7
138	R:R:G180	R:R:I183	3.53	No	No	0	7	4
139	R:R:P182	R:R:V181	3.53	No	No	0	7	4
140	R:R:M186	R:R:P182	3.35	No	No	0	4	7
141	R:R:M186	R:R:V185	4.56	No	No	0	4	4
142	R:R:R190	R:R:V188	6.54	No	No	0	3	4
143	R:R:T189	R:R:V196	4.76	Yes	No	0	4	4
144	R:R:C198	R:R:T189	3.38	No	Yes	2	9	4
145	R:R:P191	R:R:R190	2.88	No	No	0	1	3
146	R:R:R190	R:R:R192	3.2	No	No	0	3	1
147	R:R:F202	R:R:L200	8.53	Yes	No	0	6	4
148	R:R:F202	R:R:W209	6.01	Yes	No	0	6	4
149	R:R:P205	R:R:W207	4.05	No	No	0	2	3
150	R:R:P205	R:R:Y208	13.91	No	No	9	2	3
151	R:R:P205	R:R:W209	2.7	No	No	9	2	4
152	R:R:S206	R:R:W207	3.71	No	No	0	3	3
153	R:R:W209	R:R:Y208	8.68	No	No	9	4	3
154	R:R:V212	R:R:Y208	5.05	No	No	0	4	3
155	R:R:D210	R:R:T211	4.34	No	No	0	4	2
156	R:R:D210	R:R:K214	4.15	No	No	0	4	5
157	R:R:T211	R:R:T285	3.14	No	No	0	2	4
158	R:R:K214	R:R:T285	9.01	No	No	0	5	4
159	R:R:F218	R:R:F222	7.5	Yes	Yes	1	5	8
160	R:R:F218	R:R:V223	5.24	Yes	No	1	5	4
161	R:R:F218	R:R:H278	9.05	Yes	Yes	1	5	7
162	R:R:F222	R:R:V223	2.62	Yes	No	1	8	4
163	R:R:F222	R:R:F270	4.29	Yes	No	0	8	9
164	R:R:F222	R:R:H278	3.39	Yes	Yes	1	8	7
165	R:R:P225	R:R:V224	3.53	No	No	0	8	5
166	R:R:F270	R:R:I226	7.54	No	No	0	9	6
167	R:R:V263	R:R:Y233	6.31	No	No	0	7	8
168	R:R:L237	R:R:M236	2.83	Yes	No	0	5	8
169	R:R:L237	R:R:T260	5.9	Yes	No	0	5	7
170	R:R:L237	R:R:V263	2.98	Yes	No	0	5	7
171	R:R:R239	R:R:S242	2.64	Yes	No	0	5	4
172	R:R:R239	R:R:V243	7.85	Yes	No	0	5	6
173	R:R:L240	R:R:L256	2.77	No	No	0	8	6
174	R:R:I259	R:R:L240	4.28	No	No	0	8	8
175	R:R:L245	R:R:S255	7.51	No	No	0	3	5
176	R:R:K252	R:R:L246	9.87	No	No	0	2	2
177	R:R:L246	R:R:L256	4.15	No	No	0	2	6
178	R:R:E251	R:R:S247	4.31	No	No	0	3	3
179	R:R:D253	R:R:K252	16.59	No	No	0	2	2
180	R:R:D253	R:R:R257	5.96	No	No	0	2	5
181	R:R:R254	R:R:S255	2.64	No	No	0	4	5
182	R:R:E323	R:R:R258	18.61	No	No	10	4	7
183	R:R:K326	R:R:R258	7.43	No	No	10	8	7
184	R:R:L264	R:R:T260	2.95	No	No	0	5	7
185	R:R:R261	R:R:V265	5.23	No	No	0	6	6
186	R:R:M262	R:R:V266	3.04	No	No	0	8	7
187	R:R:L321	R:R:M262	15.55	No	No	0	6	8
188	R:R:L317	R:R:V265	4.47	No	No	0	8	6
189	R:R:L321	R:R:V265	2.98	No	No	0	6	6
190	R:R:C273	R:R:N310	6.3	No	Yes	0	8	9
191	R:R:H278	R:R:W274	4.23	Yes	Yes	1	7	8
192	R:R:N310	R:R:W274	12.43	Yes	Yes	1	9	8
193	R:R:C303	R:R:P276	3.77	No	No	0	6	9
194	R:R:F280	R:R:W284	3.01	Yes	No	0	5	4
195	R:R:F280	R:R:V296	2.62	Yes	No	0	5	5
196	R:R:F280	R:R:L300	8.53	Yes	No	0	5	5
197	R:R:R291	R:R:W284	15.99	No	No	0	1	4
198	R:R:I289	R:R:V287	3.07	No	No	0	1	3
199	R:R:D290	R:R:R292	8.34	No	No	0	3	1
200	R:R:D290	R:R:D293	3.99	No	Yes	0	3	3
201	R:R:D293	R:R:P294	8.05	Yes	No	0	3	2
202	R:R:D293	R:R:L295	4.07	Yes	No	0	3	2
203	R:R:D293	R:R:V296	8.76	Yes	No	0	3	5
204	R:R:N310	R:R:N314	5.45	Yes	No	0	9	9
205	R:R:L313	R:R:L317	4.15	No	No	11	7	8
206	R:R:D322	R:R:Y318	9.2	No	Yes	4	8	9
207	R:R:F325	R:R:Y318	8.25	No	Yes	4	8	9
208	R:R:A319	R:R:F325	2.77	No	No	0	7	8
209	R:R:D322	R:R:N324	8.08	No	No	0	8	7
210	R:R:D322	R:R:F325	3.58	No	No	4	8	8
211	R:R:E323	R:R:K326	4.05	No	No	10	4	8
212	R:R:F202	R:R:T213	2.59	Yes	No	0	6	6
213	R:R:F137	R:R:I136	2.51	No	No	0	6	7
214	R:R:F270	R:R:I136	2.51	No	No	0	9	7
215	R:R:T78	R:R:Y318	2.5	No	Yes	0	6	9
216	R:R:V124	R:R:W114	2.45	No	Yes	0	5	8
217	R:R:F218	R:R:L219	2.44	Yes	No	0	5	4
218	R:R:L238	R:R:R241	2.43	No	No	0	4	4
219	R:R:I148	R:R:Y147	2.42	No	Yes	0	5	8
220	R:R:D210	R:R:F202	2.39	No	Yes	0	4	6
221	R:R:D193	R:R:R192	2.38	No	No	0	1	1
222	R:R:L48	R:R:Y109	2.34	No	Yes	0	2	4
223	R:R:E323	R:R:R254	2.33	No	No	0	4	4
224	L:L:?1	R:R:V217	2.23	Yes	No	0	0	5
225	R:R:A275	R:R:P276	1.87	No	No	0	6	9
226	R:R:G248	R:R:S247	1.86	No	No	0	2	3
227	R:R:G268	R:R:V271	1.84	No	No	0	5	6
228	R:R:G73	R:R:T78	1.82	No	No	0	8	6
229	R:R:A165	R:R:A83	1.79	No	No	0	7	5
230	R:R:G307	R:R:I277	1.76	No	No	0	7	5
231	R:R:A107	R:R:S106	1.71	No	No	0	3	6
232	R:R:C232	R:R:V144	1.71	Yes	No	0	8	7
233	R:R:G234	R:R:L237	1.71	No	Yes	0	3	5
234	R:R:C273	R:R:V272	1.71	No	No	0	8	6
235	R:R:G307	R:R:L306	1.71	No	No	0	7	7
236	R:R:A309	R:R:V59	1.7	No	Yes	0	5	7
237	R:R:C60	R:R:T99	1.69	No	No	0	6	6
238	R:R:I86	R:R:P162	1.69	Yes	No	0	6	3
239	R:R:C232	R:R:I228	1.64	Yes	No	0	8	7
240	R:R:L306	R:R:P276	1.64	No	No	0	7	9
241	R:R:C303	R:R:I277	1.64	No	No	0	6	5
242	R:R:A165	R:R:I86	1.62	No	Yes	0	7	6
243	R:R:S177	R:R:V181	1.62	No	No	0	4	4
244	R:R:A187	R:R:K122	1.61	No	No	0	4	7
245	R:R:S57	R:R:T53	1.6	No	No	0	4	6
246	R:R:V283	R:R:V287	1.6	No	No	0	4	3
247	R:R:T213	R:R:V217	1.59	No	No	0	6	5
248	R:R:T230	R:R:V267	1.59	No	No	0	4	7
249	R:R:C273	R:R:L313	1.59	No	No	0	8	7
250	R:R:A187	R:R:L125	1.58	No	No	0	4	5
251	R:R:A269	R:R:L313	1.58	No	No	11	6	7
252	R:R:A269	R:R:L317	1.58	No	No	11	6	8
253	R:R:A305	R:R:L302	1.58	No	No	0	5	5
254	R:R:I226	R:R:V271	1.54	No	No	0	6	6
255	R:R:I229	R:R:V267	1.54	No	No	0	8	7
256	R:R:I289	R:R:V296	1.54	No	No	0	1	5
257	R:R:H152	R:R:P153	1.53	No	No	0	6	8
258	R:R:I282	R:R:T285	1.52	No	No	0	6	4
259	R:R:F72	R:R:G73	1.51	No	No	0	4	8
260	R:R:L48	R:R:S45	1.5	No	No	0	2	6
261	R:R:G73	R:R:R76	1.5	No	No	0	8	5
262	R:R:K81	R:R:T82	1.5	No	No	0	6	7
263	R:R:L227	R:R:V231	1.49	No	No	0	4	4
264	R:R:L235	R:R:V231	1.49	No	No	0	4	4
265	R:R:L245	R:R:V243	1.49	No	No	0	3	6
266	R:R:D253	R:R:S249	1.47	No	No	0	2	2
267	R:R:F202	R:R:P203	1.44	Yes	No	0	6	6
268	R:R:Q201	R:R:V188	1.43	No	No	0	4	4
269	R:R:G117	R:R:W114	1.41	No	Yes	0	7	8
270	R:R:A299	R:R:F280	1.39	No	Yes	0	5	5
271	R:R:L119	R:R:L120	1.38	No	No	0	3	6
272	R:R:C328	R:R:Y77	1.34	No	No	0	6	5
273	R:R:E251	R:R:L245	1.33	No	No	0	3	3
274	R:R:F133	R:R:V179	1.31	No	No	0	7	4
275	R:R:F159	R:R:I148	1.26	No	No	0	3	5
276	R:R:F220	R:R:L219	1.22	No	No	0	4	4
277	R:R:L256	R:R:R241	1.21	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.08563	16	1	0
2	R:R:Y56	6.47333	6	0	7
3	R:R:V59	3.1275	4	0	7
4	R:R:I86	3.345	4	0	6
5	R:R:Y87	6.848	5	6	7
6	R:R:L91	4.6475	4	0	9
7	R:R:D95	5.7	5	3	9
8	R:R:L102	10.3575	4	0	7
9	R:R:Y109	8.46	4	0	4
10	R:R:W114	7.37714	7	2	8
11	R:R:F116	10.63	4	2	7
12	R:R:D128	6.3325	4	1	5
13	R:R:Y130	5.2125	4	7	5
14	R:R:Y147	6.774	5	8	8
15	R:R:T189	3.9375	4	2	4
16	R:R:F202	4.192	5	0	6
17	R:R:F218	6.0575	4	1	5
18	R:R:F222	4.45	4	1	8
19	R:R:C232	3.8075	4	0	8
20	R:R:L237	3.355	4	0	5
21	R:R:R239	3.975	4	0	5
22	R:R:W274	8.68	4	1	8
23	R:R:H278	6.0925	4	1	7
24	R:R:F280	3.8875	4	0	5
25	R:R:D293	6.2175	4	0	3
26	R:R:N310	7.0725	4	1	9
27	R:R:Y318	8.406	5	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I304	73.246	7.48	Yes	No	0	0	5
2	R:R:I304	R:R:Y56	22.8856	4.84	No	Yes	0	5	7
3	R:R:H301	R:R:Y56	11.1064	10.89	No	Yes	0	4	7
4	L:L:?1	R:R:Y308	11.4608	7.02	Yes	No	1	0	7
5	R:R:L102	R:R:Y308	10.6259	23.45	Yes	No	0	7	7
6	L:L:?1	R:R:S311	17.6297	4.49	Yes	No	0	0	9
7	R:R:D95	R:R:S311	13.0166	11.78	Yes	No	0	9	9
8	L:L:?1	R:R:S135	62.4159	4.49	Yes	No	0	0	9
9	R:R:L91	R:R:S135	60.0853	3	Yes	No	0	9	9
10	R:R:L91	R:R:T138	68.4947	7.37	Yes	No	0	9	8
11	R:R:N90	R:R:T138	67.4075	4.39	No	No	0	9	8
12	R:R:N169	R:R:N90	59.2383	12.26	No	No	0	7	9
13	R:R:N169	R:R:Y87	52.1264	11.63	No	Yes	0	7	7
14	R:R:M142	R:R:Y87	45.4649	4.79	No	Yes	0	9	7
15	R:R:I88	R:R:M142	43.6809	2.92	No	No	0	8	9
16	R:R:I88	R:R:Y318	36.4729	14.51	No	Yes	0	8	9
17	R:R:V70	R:R:Y318	14.0798	7.57	No	Yes	0	8	9
18	R:R:A92	R:R:V70	10.1153	3.39	No	No	0	9	8
19	R:R:T78	R:R:Y318	13.6893	2.5	No	Yes	0	6	9
20	R:R:I86	R:R:N169	14.1639	4.25	Yes	No	0	6	7
21	R:R:M141	R:R:Y87	20.3988	8.38	No	Yes	6	7	7
22	L:L:?1	R:R:H278	83.9921	7.7	Yes	Yes	1	0	7
23	R:R:F222	R:R:H278	83.5296	3.39	Yes	Yes	1	8	7
24	R:R:F222	R:R:F270	83.5536	4.29	Yes	No	0	8	9
25	R:R:F270	R:R:I136	80.5022	2.51	No	No	0	9	7
26	R:R:F137	R:R:I136	27.4027	2.51	No	No	0	6	7
27	R:R:F137	R:R:I172	21.9966	3.77	No	No	0	6	6
28	R:R:I172	R:R:M141	20.7593	4.37	No	No	0	6	7
29	R:R:N90	R:R:W173	18.2124	11.3	No	No	0	9	9
30	L:L:?1	R:R:N310	22.4291	4.11	Yes	Yes	1	0	9
31	R:R:N310	R:R:N314	11.1305	5.45	Yes	No	0	9	9
32	L:L:?1	R:R:D128	53.2016	11.17	Yes	Yes	1	0	5
33	R:R:D128	R:R:Q105	50.4385	5.22	Yes	No	0	5	5
34	R:R:K108	R:R:Q105	97.8616	12.2	No	No	0	4	5
35	R:R:K108	R:R:W114	100	6.96	No	Yes	0	4	8
36	R:R:F116	R:R:W114	20.2487	15.03	Yes	Yes	2	7	8
37	R:R:I304	R:R:Q105	49.8258	2.74	No	No	0	5	5
38	R:R:C121	R:R:W114	24.976	9.14	No	Yes	2	9	8
39	R:R:V196	R:R:W114	24.982	4.9	No	Yes	0	4	8
40	R:R:C198	R:R:W114	24.8018	11.75	No	Yes	2	9	8
41	R:R:C121	R:R:T189	22.2489	3.38	No	Yes	2	9	4
42	R:R:E118	R:R:T189	58.4395	4.23	No	Yes	0	4	4
43	R:R:T189	R:R:V196	22.2549	4.76	Yes	No	0	4	4
44	R:R:C198	R:R:T189	22.2489	3.38	No	Yes	2	9	4
45	R:R:E118	R:R:V188	50.1261	8.56	No	No	0	4	4
46	L:L:?1	R:R:Y129	14.8486	10.53	Yes	No	0	0	5
47	R:R:I183	R:R:Y129	13.0106	14.51	No	No	0	4	5
48	R:R:W173	R:R:Y130	14.2059	10.61	No	Yes	7	9	5
49	R:R:S177	R:R:Y130	10.2355	3.82	No	Yes	0	4	5
50	R:R:I136	R:R:P225	85.9443	3.39	No	No	0	7	8
51	R:R:P225	R:R:T140	83.1331	3.5	No	No	0	8	7
52	R:R:I228	R:R:T140	81.7095	4.56	No	No	0	7	7
53	R:R:C232	R:R:I228	80.2739	1.64	Yes	No	0	8	7
54	R:R:C232	R:R:S143	21.9185	5.16	Yes	No	0	8	9
55	R:R:S143	R:R:Y233	14.6624	10.17	No	No	0	9	8
56	R:R:C232	R:R:Y147	57.8808	6.72	Yes	Yes	0	8	8
57	R:R:C151	R:R:Y147	44.5579	6.72	No	Yes	8	7	8
58	R:R:V263	R:R:Y233	11.2266	6.31	No	No	0	7	8
59	R:R:C151	R:R:R239	43.2364	2.79	No	Yes	0	7	5
60	R:R:R239	R:R:V150	23.0358	2.62	Yes	No	0	5	8
61	R:R:L240	R:R:V150	19.3477	4.47	No	No	0	8	8
62	R:R:R190	R:R:V188	33.4635	6.54	No	No	0	3	4
63	R:R:R190	R:R:R192	16.7528	3.2	No	No	0	3	1
64	L:L:?1	R:R:V217	32.154	2.23	Yes	No	0	0	5
65	R:R:T213	R:R:V217	30.5622	1.59	No	No	0	6	5
66	R:R:F202	R:R:T213	28.8323	2.59	Yes	No	0	6	6
67	R:R:F202	R:R:W209	11.3467	6.01	Yes	No	0	6	4
68	R:R:D210	R:R:F202	12.8964	2.39	No	Yes	0	4	6
69	R:R:R239	R:R:V243	19.2095	7.85	Yes	No	0	5	6
70	R:R:L240	R:R:L256	15.6595	2.77	No	No	0	8	6
71	R:R:L245	R:R:V243	17.3114	1.49	No	No	0	3	6
72	R:R:C273	R:R:N310	28.7662	6.3	No	Yes	0	8	9
73	R:R:C273	R:R:L313	23.0718	1.59	No	No	0	8	7
74	R:R:L313	R:R:L317	17.2934	4.15	No	No	11	7	8
75	R:R:L317	R:R:V265	14.4342	4.47	No	No	0	8	6
76	L:L:?1	R:R:I277	11.3467	6.41	Yes	No	0	0	5
77	L:L:?1	R:R:W284	22.5793	6.82	Yes	No	0	0	4
78	R:R:F280	R:R:W284	19.4378	3.01	Yes	No	0	5	4
79	L:L:?1	R:R:L300	20.9695	3.11	Yes	No	0	0	5
80	R:R:F280	R:R:L300	19.3657	8.53	Yes	No	0	5	5
81	R:R:F280	R:R:V296	31.9858	2.62	Yes	No	0	5	5
82	R:R:I289	R:R:V296	10.722	1.54	No	No	0	1	5
83	R:R:D293	R:R:V296	18.0442	8.76	Yes	No	0	3	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A98	4.72	1	Yes	No	0	6	0	1
L:L:?1	R:R:D128	11.17	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y129	10.53	1	Yes	No	0	5	0	1
L:L:?1	R:R:M132	5.29	1	Yes	No	0	8	0	1
L:L:?1	R:R:S135	4.49	1	Yes	No	0	9	0	1
L:L:?1	R:R:W274	11.08	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I277	6.41	1	Yes	No	0	5	0	1
L:L:?1	R:R:H278	7.7	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V281	16.72	1	Yes	No	0	6	0	1
L:L:?1	R:R:W284	6.82	1	Yes	No	0	4	0	1
L:L:?1	R:R:L300	3.11	1	Yes	No	0	5	0	1
L:L:?1	R:R:I304	7.48	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y308	7.02	1	Yes	No	0	7	0	1
L:L:?1	R:R:N310	4.11	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S311	4.49	1	Yes	No	0	9	0	1
R:R:L102	R:R:Y56	11.72	0	Yes	Yes	7	7	2	2
R:R:I304	R:R:Y56	4.84	0	No	Yes	5	7	1	2
R:R:D95	R:R:L91	4.07	3	Yes	Yes	9	9	2	2
R:R:L91	R:R:S135	3	0	Yes	No	9	9	2	1
R:R:A94	R:R:S135	3.42	0	No	No	8	9	2	1
R:R:D95	R:R:S311	11.78	3	Yes	No	9	9	2	1
R:R:D95	R:R:N314	5.39	3	Yes	No	9	9	2	2
R:R:A98	R:R:N131	6.25	0	No	No	6	8	1	2
R:R:S311	R:R:T99	3.2	0	No	No	9	6	1	2
R:R:D128	R:R:T101	4.34	1	Yes	No	5	7	1	2
R:R:L102	R:R:Y308	23.45	0	Yes	No	7	7	2	1
R:R:D128	R:R:Q105	5.22	1	Yes	No	5	5	1	2
R:R:I304	R:R:Q105	2.74	0	No	No	5	5	1	2
R:R:D128	R:R:Y308	4.6	1	Yes	No	5	7	1	1
R:R:I183	R:R:Y129	14.51	0	No	No	4	5	2	1
R:R:M132	R:R:W274	6.98	1	No	Yes	8	8	1	1
R:R:F218	R:R:F222	7.5	1	Yes	Yes	5	8	2	2
R:R:F218	R:R:H278	9.05	1	Yes	Yes	5	7	2	1
R:R:F222	R:R:H278	3.39	1	Yes	Yes	8	7	2	1
R:R:C273	R:R:N310	6.3	0	No	Yes	8	9	2	1
R:R:H278	R:R:W274	4.23	1	Yes	Yes	7	8	1	1
R:R:N310	R:R:W274	12.43	1	Yes	Yes	9	8	1	1
R:R:F280	R:R:W284	3.01	0	Yes	No	5	4	2	1
R:R:F280	R:R:L300	8.53	0	Yes	No	5	5	2	1
R:R:R291	R:R:W284	15.99	0	No	No	1	4	2	1
R:R:N310	R:R:N314	5.45	1	Yes	No	9	9	1	2
L:L:?1	R:R:V217	2.23	1	Yes	No	0	5	0	1
R:R:G307	R:R:I277	1.76	0	No	No	7	5	2	1
R:R:C303	R:R:I277	1.64	0	No	No	6	5	2	1
R:R:T213	R:R:V217	1.59	0	No	No	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9CGK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	246
Number of Links	277
Number of Hubs	27
Number of Links mediated by Hubs	116
Number of Communities	11
Number of Nodes involved in Communities	47
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	48490
Length Of Smallest Path	3
Average Path Length	13.3286
Length of Longest Path	30
Minimum Path Strength	1.41
Average Path Strength	5.74819
Maximum Path Strength	17.585
Minimum Path Correlation	0.7
Average Path Correlation	0.924708
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	48.9869
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.1336
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled enkephalin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • neuropeptide binding • peptide binding • receptor serine/threonine kinase binding • signaling receptor binding • neuropeptide signaling pathway • adult locomotory behavior • behavior • adult behavior • locomotory behavior • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • immune response • immune system process • regulation of mitochondrial membrane potential • regulation of biological quality • regulation of membrane potential • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • G protein-coupled opioid receptor signaling pathway • eating behavior • feeding behavior • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • response to ethanol • cellular response to growth factor stimulus • response to growth factor • cellular response to toxic substance • response to toxic substance • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • regulation of biosynthetic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of macromolecule metabolic process • response to nicotine • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • postsynapse • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • presynapse • presynaptic membrane • cell leading edge • leading edge membrane • somatodendritic compartment • neuron projection membrane • dendrite membrane • dendrite • dendritic tree • cell projection membrane • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus • neuron spine • dendritic spine • spine apparatus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>9CGK_nogp_Chain_R S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P R D G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F K R C F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9YDP	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDP (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-		1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDQ	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDQ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614		1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDR	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983	chim(NtGi1L-Gs-CtGi1)/β1/γ2	2.14	2025-12-10	10.1101/2025.10.16.682975
	9YDR (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983		2.14	2025-12-10	10.1101/2025.10.16.682975
	8Y71	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187	Gi1/β1/γ2	2.97	2026-01-07	To be published
	8Y71 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187		2.97	2026-01-07	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9CGK_nogp.zip

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