psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I52	R:R:L48	4.28	No	No	0	5	2
2	R:R:A298	R:R:L48	4.73	No	No	0	1	2
3	R:R:I52	R:R:Y109	12.09	No	Yes	0	5	4
4	R:R:S106	R:R:T53	4.8	No	Yes	0	6	6
5	R:R:L110	R:R:T53	10.32	No	Yes	0	4	6
6	R:R:A305	R:R:L55	3.15	No	No	0	5	5
7	R:R:H301	R:R:Y56	13.07	No	No	0	4	7
8	R:R:I304	R:R:Y56	6.04	No	No	0	5	7
9	R:R:I309	R:R:V59	4.61	No	No	0	5	7
10	R:R:C60	R:R:L64	3.17	No	No	0	6	6
11	R:R:C60	R:R:L102	6.35	No	No	0	6	7
12	R:R:C60	R:R:P103	3.77	No	No	0	6	8
13	R:R:L313	R:R:V62	2.98	No	No	0	7	4
14	R:R:G63	R:R:S312	3.71	No	No	0	8	7
15	R:R:L64	R:R:T99	7.37	No	No	0	6	6
16	R:R:G66	R:R:V316	3.68	No	No	0	7	6
17	R:R:A96	R:R:N67	4.69	No	No	0	7	9
18	R:R:N67	R:R:S312	2.98	No	No	0	9	7
19	R:R:N67	R:R:V316	2.96	No	No	0	9	6
20	R:R:I74	R:R:V70	3.07	No	Yes	0	7	8
21	R:R:V316	R:R:V70	4.81	No	Yes	0	6	8
22	R:R:A319	R:R:V70	3.39	No	Yes	0	7	8
23	R:R:F89	R:R:M71	8.71	Yes	No	0	6	7
24	R:R:L93	R:R:M71	2.83	No	No	0	6	7
25	R:R:F72	R:R:R76	8.55	No	No	0	4	5
26	R:R:F325	R:R:V73	6.55	Yes	No	0	8	8
27	R:R:I74	R:R:I88	2.94	No	Yes	0	7	8
28	R:R:F89	R:R:I74	5.02	Yes	No	0	6	7
29	R:R:F89	R:R:V75	3.93	Yes	No	0	6	3
30	R:R:R76	R:R:Y77	6.17	No	No	0	5	5
31	R:R:N85	R:R:T78	4.39	No	No	0	8	6
32	R:R:I86	R:R:M80	2.92	Yes	No	0	6	7
33	R:R:F89	R:R:M80	8.71	Yes	No	0	6	7
34	R:R:T82	R:R:T84	3.14	No	No	0	7	8
35	R:R:N85	R:R:T82	7.31	No	No	0	8	7
36	R:R:I86	R:R:K166	4.36	Yes	No	0	6	3
37	R:R:I86	R:R:N169	2.83	Yes	No	0	6	7
38	R:R:D145	R:R:Y87	9.2	No	Yes	0	8	7
39	R:R:A165	R:R:Y87	4	No	Yes	0	7	7
40	R:R:N169	R:R:Y87	9.3	No	Yes	0	7	7
41	R:R:I88	R:R:M142	4.37	Yes	No	0	8	9
42	R:R:S90	R:R:T138	4.8	No	No	0	9	8
43	R:R:N169	R:R:S90	7.45	No	No	0	7	9
44	R:R:S90	R:R:W173	6.18	No	Yes	0	9	9
45	R:R:L91	R:R:S135	3	No	No	0	9	9
46	R:R:L91	R:R:T138	4.42	No	No	0	9	8
47	R:R:L91	R:R:P315	6.57	No	No	0	9	9
48	R:R:L93	R:R:W173	5.69	No	Yes	0	6	9
49	R:R:A94	R:R:T134	3.36	No	No	0	8	8
50	R:R:A94	R:R:S135	3.42	No	No	0	8	9
51	R:R:I127	R:R:L97	2.85	No	No	0	5	7
52	R:R:L97	R:R:S131	4.5	No	No	0	7	8
53	R:R:A98	R:R:S131	3.42	No	No	0	6	8
54	R:R:S312	R:R:T99	7.99	No	No	0	7	6
55	R:R:Q105	R:R:T101	5.67	No	No	0	5	7
56	R:R:I127	R:R:T101	3.04	No	No	0	5	7
57	R:R:L102	R:R:Y308	15.24	No	No	0	7	7
58	R:R:F104	R:R:F116	9.65	No	Yes	1	6	7
59	R:R:F104	R:R:L120	3.65	No	No	1	6	6
60	R:R:F104	R:R:V124	3.93	No	No	0	6	5
61	R:R:Q105	R:R:Y308	11.27	No	No	0	5	7
62	L:L:F3	R:R:Q105	10.54	Yes	No	0	0	5
63	R:R:K108	R:R:W114	4.64	No	Yes	1	4	8
64	L:L:G7	R:R:K108	3.49	No	No	1	0	4
65	L:L:?8	R:R:K108	10.47	Yes	No	1	0	4
66	R:R:H301	R:R:Y109	8.71	No	Yes	0	4	4
67	R:R:M111	R:R:P115	3.35	No	No	0	4	3
68	R:R:T113	R:R:V196	3.17	No	No	0	4	4
69	R:R:F116	R:R:W114	17.04	Yes	Yes	1	7	8
70	R:R:C121	R:R:W114	3.92	No	Yes	1	9	8
71	R:R:C198	R:R:W114	6.53	Yes	Yes	1	9	8
72	L:L:F3	R:R:W114	5.01	Yes	Yes	1	0	8
73	R:R:F116	R:R:P115	5.78	Yes	No	0	7	3
74	R:R:F116	R:R:L120	6.09	Yes	No	1	7	6
75	R:R:E118	R:R:K122	5.4	No	No	0	4	7
76	R:R:E118	R:R:V188	2.85	No	No	0	4	4
77	R:R:E118	R:R:T189	5.64	No	No	0	4	4
78	R:R:C121	R:R:T189	3.38	No	No	0	9	4
79	R:R:C121	R:R:C198	7.28	No	Yes	1	9	9
80	R:R:A187	R:R:K122	3.21	No	No	0	4	7
81	R:R:C198	R:R:L125	3.17	Yes	No	1	9	5
82	L:L:F3	R:R:L125	4.87	Yes	No	1	0	5
83	R:R:M184	R:R:S126	6.13	No	No	0	4	6
84	R:R:D128	R:R:Y308	9.2	No	No	0	5	7
85	R:R:I183	R:R:Y129	12.09	No	No	0	4	5
86	L:L:Y1	R:R:Y129	6.95	Yes	No	0	0	5
87	L:L:E4	R:R:Y129	6.73	No	No	0	0	5
88	R:R:T134	R:R:Y130	7.49	No	Yes	3	8	5
89	R:R:W173	R:R:Y130	9.65	Yes	Yes	3	9	5
90	R:R:A176	R:R:Y130	4	No	Yes	0	8	5
91	R:R:S177	R:R:Y130	6.36	No	Yes	0	4	5
92	R:R:F133	R:R:M132	3.73	No	No	0	7	8
93	R:R:M132	R:R:W274	5.82	No	Yes	0	8	8
94	L:L:Y1	R:R:M132	8.38	Yes	No	0	0	8
95	R:R:F133	R:R:F137	3.22	No	No	0	7	6
96	R:R:F133	R:R:V179	6.55	No	No	0	7	4
97	R:R:T134	R:R:W173	12.13	No	Yes	3	8	9
98	R:R:I136	R:R:P225	3.39	No	No	0	7	8
99	R:R:I136	R:R:W274	3.52	No	Yes	0	7	8
100	R:R:L139	R:R:V266	2.98	No	No	4	8	7
101	R:R:L139	R:R:Y318	4.69	No	No	4	8	9
102	R:R:P225	R:R:T140	3.5	No	No	0	8	7
103	R:R:I228	R:R:T140	4.56	No	No	0	7	7
104	R:R:I168	R:R:M141	4.37	No	No	0	5	7
105	R:R:I172	R:R:M141	2.92	No	No	0	6	7
106	R:R:M142	R:R:R146	3.72	No	No	0	9	9
107	R:R:C143	R:R:I229	11.46	No	No	5	9	8
108	R:R:C143	R:R:Y233	10.75	No	Yes	5	9	8
109	R:R:I148	R:R:V144	3.07	No	No	0	5	7
110	R:R:D145	R:R:R160	11.91	No	No	0	8	6
111	R:R:R146	R:R:Y233	8.23	No	Yes	0	9	8
112	R:R:C151	R:R:Y147	8.06	No	Yes	0	7	8
113	R:R:H152	R:R:Y147	6.53	No	Yes	0	6	8
114	R:R:C232	R:R:Y147	9.41	No	Yes	0	8	8
115	R:R:L235	R:R:Y147	7.03	No	Yes	0	4	8
116	R:R:F159	R:R:I148	12.56	No	No	0	3	5
117	R:R:A149	R:R:R160	5.53	No	No	0	8	6
118	R:R:M236	R:R:V150	7.61	No	No	0	8	8
119	R:R:K164	R:R:T161	6.01	No	No	0	4	7
120	R:R:P182	R:R:V181	3.53	No	No	0	7	4
121	R:R:I183	R:R:L200	4.28	No	No	0	4	4
122	R:R:F202	R:R:M186	3.73	Yes	No	0	6	4
123	R:R:Q201	R:R:V188	7.16	No	No	0	4	4
124	R:R:M199	R:R:R190	3.72	No	No	0	4	3
125	R:R:Q201	R:R:R190	9.35	No	No	0	4	3
126	R:R:R192	R:R:V197	10.46	No	No	0	1	4
127	R:R:R192	R:R:R291	11.73	No	No	0	1	1
128	L:L:G7	R:R:V197	3.68	No	No	0	0	4
129	L:L:F3	R:R:C198	5.59	Yes	Yes	1	0	9
130	R:R:F202	R:R:L200	3.65	Yes	No	0	6	4
131	L:L:E4	R:R:L200	5.3	No	No	0	0	4
132	R:R:F202	R:R:W209	3.01	Yes	No	0	6	4
133	R:R:D210	R:R:F202	14.33	No	Yes	0	4	6
134	R:R:F202	R:R:T213	9.08	Yes	No	0	6	6
135	R:R:P203	R:R:W209	6.76	No	No	0	6	4
136	R:R:P205	R:R:S204	7.13	No	No	0	2	4
137	R:R:P205	R:R:W207	4.05	No	No	0	2	3
138	R:R:W207	R:R:Y208	7.72	No	No	0	3	3
139	R:R:V212	R:R:Y208	6.31	No	No	0	4	3
140	R:R:D210	R:R:K214	8.3	No	Yes	6	4	5
141	R:R:D210	R:R:T285	2.89	No	No	6	4	4
142	R:R:T211	R:R:T285	3.14	No	No	0	2	4
143	R:R:K214	R:R:V281	4.55	Yes	No	0	5	6
144	R:R:K214	R:R:T285	9.01	Yes	No	6	5	4
145	L:L:E4	R:R:K214	9.45	No	Yes	0	0	5
146	R:R:I215	R:R:I282	2.94	No	No	0	4	6
147	L:L:Y1	R:R:V217	5.05	Yes	No	0	0	5
148	R:R:F218	R:R:F222	9.65	Yes	Yes	2	5	8
149	R:R:F218	R:R:H278	5.66	Yes	Yes	2	5	7
150	R:R:F218	R:R:I282	5.02	Yes	No	0	5	6
151	R:R:L219	R:R:V223	4.47	No	No	0	4	4
152	R:R:F222	R:R:I226	7.54	Yes	No	0	8	6
153	R:R:F222	R:R:H278	3.39	Yes	Yes	2	8	7
154	R:R:P225	R:R:V224	3.53	No	No	0	8	5
155	R:R:I228	R:R:V224	3.07	No	No	0	7	5
156	R:R:F270	R:R:I226	5.02	No	No	0	9	6
157	R:R:I226	R:R:V271	3.07	No	No	0	6	6
158	R:R:I229	R:R:Y233	3.63	No	Yes	5	8	8
159	R:R:V263	R:R:Y233	8.83	No	Yes	0	7	8
160	R:R:L240	R:R:M236	4.24	No	No	0	8	8
161	R:R:L237	R:R:T260	5.9	No	No	0	5	7
162	R:R:L238	R:R:R241	3.64	No	No	0	4	4
163	R:R:L240	R:R:L246	5.54	No	Yes	0	8	2
164	R:R:L245	R:R:V243	2.98	No	No	0	3	6
165	R:R:L246	R:R:V243	4.47	Yes	No	0	2	6
166	R:R:L246	R:R:S255	3	Yes	No	0	2	5
167	R:R:L246	R:R:L256	9.69	Yes	No	0	2	6
168	R:R:I259	R:R:L246	2.85	No	Yes	0	8	2
169	R:R:G248	R:R:S247	3.71	No	No	0	2	3
170	R:R:K252	R:R:S249	7.65	No	No	0	2	2
171	R:R:E251	R:R:R254	9.3	No	No	0	3	4
172	R:R:L256	R:R:T260	2.95	No	No	0	6	7
173	R:R:R257	R:R:R261	15.99	No	No	0	5	6
174	R:R:M262	R:R:R258	4.96	No	No	0	8	7
175	R:R:L264	R:R:T260	2.95	No	No	0	5	7
176	R:R:V266	R:R:Y318	11.36	No	No	4	7	9
177	R:R:A269	R:R:N314	3.13	No	Yes	0	6	9
178	R:R:F270	R:R:W274	11.02	No	Yes	0	9	8
179	R:R:C273	R:R:N310	9.45	No	No	0	8	9
180	R:R:H278	R:R:W274	4.23	Yes	Yes	0	7	8
181	R:R:N310	R:R:W274	7.91	No	Yes	0	9	8
182	R:R:I277	R:R:V281	3.07	No	No	0	5	6
183	R:R:C303	R:R:I277	3.27	No	No	0	6	5
184	L:L:Y1	R:R:H278	3.27	Yes	Yes	0	0	7
185	R:R:F280	R:R:L300	9.74	No	Yes	0	5	5
186	R:R:R291	R:R:W284	5	No	No	0	1	4
187	L:L:V5	R:R:W284	6.13	No	No	0	0	4
188	R:R:I289	R:R:V287	6.14	No	No	0	1	3
189	R:R:D290	R:R:R292	14.29	No	No	0	3	1
190	R:R:D293	R:R:P294	6.44	No	No	0	3	2
191	R:R:D293	R:R:V296	5.84	No	No	0	3	5
192	R:R:I304	R:R:L300	4.28	No	Yes	0	5	5
193	L:L:V5	R:R:L300	2.98	No	Yes	0	0	5
194	L:L:V6	R:R:L300	2.98	No	Yes	0	0	5
195	L:L:?2	R:R:I304	8.71	Yes	No	0	0	5
196	R:R:I309	R:R:L313	7.14	No	No	0	5	7
197	R:R:N310	R:R:N314	10.9	No	Yes	0	9	9
198	R:R:L317	R:R:N314	4.12	No	Yes	0	8	9
199	R:R:N314	R:R:Y318	4.65	Yes	No	0	9	9
200	R:R:F320	R:R:F325	5.36	No	Yes	0	7	8
201	R:R:D322	R:R:N324	9.42	No	No	0	8	7
202	R:R:N324	R:R:R327	6.03	No	No	0	7	5
203	R:R:F325	R:R:F329	9.65	Yes	No	0	8	6
204	L:L:?2	L:L:Y1	4.77	Yes	Yes	0	0	0
205	L:L:?2	L:L:V5	7.58	Yes	No	0	0	0
206	L:L:?2	L:L:V6	4.55	Yes	No	0	0	0
207	L:L:?8	L:L:F3	18.09	Yes	Yes	1	0	0
208	L:L:?8	L:L:V6	7.37	Yes	No	0	0	0
209	L:L:?8	L:L:G7	4.23	Yes	No	1	0	0
210	R:R:G117	R:R:W114	2.81	No	Yes	0	7	8
211	R:R:A107	R:R:F116	2.77	No	Yes	0	3	7
212	R:R:A156	R:R:R160	2.77	No	No	0	5	6
213	R:R:A275	R:R:F222	2.77	No	Yes	0	6	8
214	R:R:H301	R:R:V297	2.77	No	No	0	4	4
215	R:R:L317	R:R:L321	2.77	No	No	0	8	6
216	R:R:A319	R:R:F325	2.77	No	Yes	0	7	8
217	R:R:D293	R:R:L295	2.71	No	No	0	3	2
218	R:R:E323	R:R:K326	2.7	No	No	0	4	8
219	R:R:A49	R:R:Y109	2.67	No	Yes	0	4	4
220	R:R:F202	R:R:S206	2.64	Yes	No	0	6	3
221	R:R:R239	R:R:S242	2.64	No	No	0	5	4
222	R:R:R239	R:R:V150	2.62	No	No	0	5	8
223	R:R:H152	R:R:K155	2.62	No	No	0	6	5
224	R:R:F218	R:R:V223	2.62	Yes	No	2	5	4
225	R:R:F222	R:R:V223	2.62	Yes	No	2	8	4
226	R:R:F280	R:R:V296	2.62	No	No	0	5	5
227	R:R:V73	R:R:Y77	2.52	No	No	0	8	5
228	R:R:V267	R:R:Y233	2.52	No	Yes	0	7	8
229	R:R:F159	R:R:I168	2.51	No	No	0	3	5
230	R:R:T53	R:R:Y109	2.5	Yes	Yes	0	6	4
231	R:R:S311	R:R:W274	2.47	No	Yes	0	9	8
232	R:R:F220	R:R:L219	2.44	No	No	0	4	4
233	R:R:I168	R:R:Y87	2.42	No	Yes	0	5	7
234	R:R:M236	R:R:Y233	2.39	No	Yes	0	8	8
235	R:R:D290	R:R:R291	2.38	No	No	0	3	1
236	R:R:A98	R:R:G95	1.95	No	No	0	6	9
237	R:R:W209	R:R:Y208	1.93	No	No	0	4	3
238	R:R:C303	R:R:P276	1.88	No	No	0	6	9
239	R:R:G180	R:R:S126	1.86	No	No	0	7	6
240	R:R:G180	R:R:V179	1.84	No	No	0	7	4
241	R:R:A165	R:R:A83	1.79	No	No	0	7	5
242	R:R:P162	R:R:T161	1.75	No	No	0	3	7
243	R:R:G66	R:R:L65	1.71	No	No	0	7	4
244	R:R:C232	R:R:V144	1.71	No	No	0	8	7
245	R:R:C216	R:R:V212	1.71	No	No	0	3	4
246	R:R:A92	R:R:V70	1.7	No	Yes	0	9	8
247	R:R:I86	R:R:P162	1.69	Yes	No	0	6	3
248	R:R:A195	R:R:T113	1.68	No	No	0	2	4
249	R:R:M186	R:R:P182	1.68	No	No	0	4	7
250	R:R:A221	R:R:I136	1.62	No	No	0	6	7
251	R:R:S57	R:R:T53	1.6	No	Yes	0	4	6
252	R:R:S100	R:R:T101	1.6	No	No	0	5	7
253	R:R:V181	R:R:V185	1.6	No	No	0	4	4
254	R:R:V268	R:R:V272	1.6	No	No	0	5	6
255	R:R:V283	R:R:V287	1.6	No	No	0	4	3
256	R:R:T189	R:R:V196	1.59	No	No	0	4	4
257	R:R:T230	R:R:V267	1.59	No	No	0	4	7
258	R:R:A123	R:R:L120	1.58	No	No	0	4	6
259	R:R:I170	R:R:V174	1.54	No	No	0	4	4
260	R:R:I279	R:R:V283	1.54	No	No	0	6	4
261	R:R:H152	R:R:P153	1.53	No	No	0	6	8
262	R:R:I88	R:R:T84	1.52	Yes	No	0	8	8
263	R:R:L46	R:R:S45	1.5	No	No	0	2	6
264	R:R:L55	R:R:V59	1.49	No	No	0	5	7
265	R:R:L102	R:R:V59	1.49	No	No	0	7	7
266	R:R:L227	R:R:V231	1.49	No	No	0	4	4
267	R:R:L235	R:R:V231	1.49	No	No	0	4	4
268	R:R:P191	R:R:R190	1.44	No	No	0	1	3
269	R:R:I282	R:R:L286	1.43	No	No	0	6	4
270	R:R:I309	R:R:L306	1.43	No	No	0	5	7
271	R:R:D322	R:R:I88	1.4	No	Yes	0	8	8
272	R:R:L302	R:R:L55	1.38	No	No	0	5	5
273	R:R:L235	R:R:L238	1.38	No	No	0	4	4
274	R:R:E323	R:R:M262	1.35	No	No	0	4	8
275	R:R:R258	R:R:S255	1.32	No	No	0	7	5
276	R:R:D193	R:R:R192	1.19	No	No	0	1	1
277	R:R:L332	R:R:Y77	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T53	4.805	4	0	6
2	R:R:V70	3.2425	4	0	8
3	R:R:I86	2.95	4	0	6
4	R:R:Y87	6.23	4	0	7
5	R:R:I88	2.5575	4	0	8
6	R:R:F89	6.5925	4	0	6
7	R:R:Y109	6.4925	4	0	4
8	R:R:W114	6.65833	6	1	8
9	R:R:F116	8.266	5	1	7
10	R:R:Y130	6.875	4	3	5
11	R:R:Y147	7.7575	4	0	8
12	R:R:W173	8.4125	4	3	9
13	R:R:C198	5.6425	4	1	9
14	R:R:F202	6.07333	6	0	6
15	R:R:K214	7.8275	4	6	5
16	R:R:F218	5.7375	4	2	5
17	R:R:F222	5.194	5	2	8
18	R:R:Y233	6.05833	6	5	8
19	R:R:L246	5.11	5	0	2
20	R:R:W274	5.82833	6	0	8
21	R:R:H278	4.1375	4	2	7
22	R:R:L300	4.995	4	0	5
23	R:R:N314	5.7	4	0	9
24	R:R:F325	6.0825	4	0	8
25	L:L:Y1	5.684	5	0	0
26	L:L:?2	6.4025	4	0	0
27	L:L:F3	8.82	5	1	0
28	L:L:?8	10.04	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L102	R:R:Y308	85.2939	15.24	No	No	0	7	7
2	R:R:Q105	R:R:Y308	85.8678	11.27	No	No	0	5	7
3	L:L:F3	R:R:Q105	87.9368	10.54	Yes	No	0	0	5
4	L:L:?8	L:L:F3	90.1813	18.09	Yes	Yes	1	0	0
5	L:L:?8	L:L:V6	100	7.37	Yes	No	0	0	0
6	L:L:V6	R:R:L300	17.031	2.98	No	Yes	0	0	5
7	R:R:I304	R:R:L300	12.0851	4.28	No	Yes	0	5	5
8	R:R:I304	R:R:Y56	22.4302	6.04	No	No	0	5	7
9	R:R:H301	R:R:Y56	20.5951	13.07	No	No	0	4	7
10	R:R:H301	R:R:Y109	16.9031	8.71	No	Yes	0	4	4
11	L:L:?2	L:L:V6	87.4068	4.55	Yes	No	0	0	0
12	L:L:?2	R:R:I304	16.819	8.71	Yes	No	0	0	5
13	R:R:C60	R:R:L102	82.1684	6.35	No	No	0	6	7
14	R:R:C60	R:R:L64	81.3935	3.17	No	No	0	6	6
15	R:R:S312	R:R:T99	80.5893	7.99	No	No	0	7	6
16	R:R:L64	R:R:T99	80.995	7.37	No	No	0	6	6
17	R:R:N67	R:R:V316	78.8931	2.96	No	No	0	9	6
18	R:R:N67	R:R:S312	79.7558	2.98	No	No	0	9	7
19	R:R:V316	R:R:V70	77.5442	4.81	No	Yes	0	6	8
20	R:R:I74	R:R:V70	72.1122	3.07	No	Yes	0	7	8
21	R:R:A319	R:R:V70	10.0344	3.39	No	Yes	0	7	8
22	R:R:F89	R:R:I74	48.8485	5.02	Yes	No	0	6	7
23	R:R:F89	R:R:M71	12.9844	8.71	Yes	No	0	6	7
24	R:R:L93	R:R:M71	12.0193	2.83	No	No	0	6	7
25	R:R:I74	R:R:I88	35.1038	2.94	No	Yes	0	7	8
26	R:R:F89	R:R:M80	34.5665	8.71	Yes	No	0	6	7
27	R:R:I86	R:R:M80	33.7001	2.92	Yes	No	0	6	7
28	R:R:I86	R:R:N169	29.3866	2.83	Yes	No	0	6	7
29	R:R:N169	R:R:Y87	25.3948	9.3	No	Yes	0	7	7
30	R:R:I88	R:R:M142	27.6137	4.37	Yes	No	0	8	9
31	R:R:L93	R:R:W173	11.1566	5.69	No	Yes	0	6	9
32	R:R:F116	R:R:W114	12.9222	17.04	Yes	Yes	1	7	8
33	R:R:K108	R:R:W114	13.3609	4.64	No	Yes	1	4	8
34	L:L:?8	R:R:K108	13.0977	10.47	Yes	No	1	0	4
35	L:L:F3	R:R:W114	23.2417	5.01	Yes	Yes	1	0	8
36	R:R:C121	R:R:W114	20.6207	3.92	No	Yes	1	9	8
37	R:R:C121	R:R:T189	31.0535	3.38	No	No	0	9	4
38	L:L:F3	R:R:C198	13.8507	5.59	Yes	Yes	1	0	9
39	R:R:C121	R:R:C198	12.9697	7.28	No	Yes	1	9	9
40	R:R:E118	R:R:T189	20.8181	5.64	No	No	0	4	4
41	R:R:E118	R:R:V188	13.0648	2.85	No	No	0	4	4
42	L:L:?2	L:L:Y1	88.8032	4.77	Yes	Yes	0	0	0
43	L:L:Y1	R:R:M132	26.6559	8.38	Yes	No	0	0	8
44	R:R:I183	R:R:Y129	18.2812	12.09	No	No	0	4	5
45	L:L:Y1	R:R:Y129	46.0192	6.95	Yes	No	0	0	5
46	L:L:E4	R:R:Y129	26.8424	6.73	No	No	0	0	5
47	R:R:M132	R:R:W274	20.1053	5.82	No	Yes	0	8	8
48	L:L:Y1	R:R:H278	34.7565	3.27	Yes	Yes	0	0	7
49	R:R:H278	R:R:W274	20.4416	4.23	Yes	Yes	0	7	8
50	R:R:I136	R:R:W274	15.0424	3.52	No	Yes	0	7	8
51	R:R:I136	R:R:P225	10.7801	3.39	No	No	0	7	8
52	R:R:N310	R:R:W274	19.2755	7.91	No	Yes	0	9	8
53	R:R:N310	R:R:N314	15.0424	10.9	No	Yes	0	9	9
54	R:R:I168	R:R:Y87	18.4311	2.42	No	Yes	0	5	7
55	R:R:M142	R:R:R146	26.6377	3.72	No	No	0	9	9
56	R:R:R146	R:R:Y233	25.6543	8.23	No	Yes	0	9	8
57	R:R:F159	R:R:I148	14.3479	12.56	No	No	0	3	5
58	R:R:F159	R:R:I168	15.3202	2.51	No	No	0	3	5
59	R:R:I148	R:R:V144	13.2878	3.07	No	No	0	5	7
60	R:R:C232	R:R:Y147	11.1456	9.41	No	Yes	0	8	8
61	R:R:C232	R:R:V144	12.2204	1.71	No	No	0	8	7
62	R:R:M236	R:R:Y233	19.5899	2.39	No	Yes	0	8	8
63	R:R:I183	R:R:L200	17.349	4.28	No	No	0	4	4
64	R:R:F202	R:R:L200	32.534	3.65	Yes	No	0	6	4
65	L:L:E4	R:R:L200	17.3636	5.3	No	No	0	0	4
66	R:R:Q201	R:R:V188	10.4657	7.16	No	No	0	4	4
67	R:R:F202	R:R:W209	17.7767	3.01	Yes	No	0	6	4
68	R:R:W209	R:R:Y208	13.3755	1.93	No	No	0	4	3
69	R:R:L240	R:R:M236	15.4006	4.24	No	No	0	8	8
70	R:R:L240	R:R:L246	14.3369	5.54	No	Yes	0	8	2

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I304	R:R:Y56	6.04	0	No	No	5	7	1	2
R:R:Q105	R:R:T101	5.67	0	No	No	5	7	1	2
R:R:Q105	R:R:Y308	11.27	0	No	No	5	7	1	2
L:L:F3	R:R:Q105	10.54	1	Yes	No	0	5	0	1
R:R:K108	R:R:W114	4.64	1	No	Yes	4	8	1	1
L:L:G7	R:R:K108	3.49	1	No	No	0	4	0	1
L:L:?8	R:R:K108	10.47	1	Yes	No	0	4	0	1
R:R:F116	R:R:W114	17.04	1	Yes	Yes	7	8	2	1
R:R:C121	R:R:W114	3.92	1	No	Yes	9	8	2	1
R:R:C198	R:R:W114	6.53	1	Yes	Yes	9	8	1	1
L:L:F3	R:R:W114	5.01	1	Yes	Yes	0	8	0	1
R:R:C121	R:R:C198	7.28	1	No	Yes	9	9	2	1
R:R:C198	R:R:L125	3.17	1	Yes	No	9	5	1	1
L:L:F3	R:R:L125	4.87	1	Yes	No	0	5	0	1
R:R:I183	R:R:Y129	12.09	0	No	No	4	5	2	1
L:L:Y1	R:R:Y129	6.95	0	Yes	No	0	5	0	1
L:L:E4	R:R:Y129	6.73	0	No	No	0	5	0	1
R:R:F133	R:R:M132	3.73	0	No	No	7	8	2	1
R:R:M132	R:R:W274	5.82	0	No	Yes	8	8	1	2
L:L:Y1	R:R:M132	8.38	0	Yes	No	0	8	0	1
R:R:I183	R:R:L200	4.28	0	No	No	4	4	2	1
R:R:R192	R:R:V197	10.46	0	No	No	1	4	2	1
R:R:R192	R:R:R291	11.73	0	No	No	1	1	2	2
L:L:G7	R:R:V197	3.68	1	No	No	0	4	0	1
L:L:F3	R:R:C198	5.59	1	Yes	Yes	0	9	0	1
R:R:F202	R:R:L200	3.65	0	Yes	No	6	4	2	1
L:L:E4	R:R:L200	5.3	0	No	No	0	4	0	1
R:R:D210	R:R:F202	14.33	6	No	Yes	4	6	2	2
R:R:D210	R:R:K214	8.3	6	No	Yes	4	5	2	1
R:R:D210	R:R:T285	2.89	6	No	No	4	4	2	2
R:R:K214	R:R:V281	4.55	6	Yes	No	5	6	1	2
R:R:K214	R:R:T285	9.01	6	Yes	No	5	4	1	2
L:L:E4	R:R:K214	9.45	0	No	Yes	0	5	0	1
L:L:Y1	R:R:V217	5.05	0	Yes	No	0	5	0	1
R:R:F218	R:R:F222	9.65	2	Yes	Yes	5	8	2	2
R:R:F218	R:R:H278	5.66	2	Yes	Yes	5	7	2	1
R:R:F222	R:R:H278	3.39	2	Yes	Yes	8	7	2	1
R:R:H278	R:R:W274	4.23	2	Yes	Yes	7	8	1	2
L:L:Y1	R:R:H278	3.27	0	Yes	Yes	0	7	0	1
R:R:F280	R:R:L300	9.74	0	No	Yes	5	5	2	1
R:R:R291	R:R:W284	5	0	No	No	1	4	2	1
L:L:V5	R:R:W284	6.13	0	No	No	0	4	0	1
R:R:I304	R:R:L300	4.28	0	No	Yes	5	5	1	1
L:L:V5	R:R:L300	2.98	0	No	Yes	0	5	0	1
L:L:V6	R:R:L300	2.98	0	No	Yes	0	5	0	1
L:L:?2	R:R:I304	8.71	0	Yes	No	0	5	0	1
R:R:G117	R:R:W114	2.81	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F7S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	264
Number of Links	277
Number of Hubs	28
Number of Links mediated by Hubs	112
Number of Communities	6
Number of Nodes involved in Communities	27
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	50262
Length Of Smallest Path	3
Average Path Length	16.9242
Length of Longest Path	39
Minimum Path Strength	1.435
Average Path Strength	6.24511
Maximum Path Strength	14.28
Minimum Path Correlation	0.7
Average Path Correlation	0.924141
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	43.5111
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.8016
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adult locomotory behavior • behavior • multicellular organismal process • adult behavior • locomotory behavior • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • immune response • immune system process • regulation of mitochondrial membrane potential • regulation of biological quality • regulation of membrane potential • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • G protein-coupled opioid receptor signaling pathway • eating behavior • feeding behavior • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • response to alcohol • response to oxygen-containing compound • response to ethanol • cellular response to endogenous stimulus • cellular response to growth factor stimulus • response to endogenous stimulus • response to growth factor • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to toxic substance • response to toxic substance • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of biosynthetic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of macromolecule metabolic process • response to nicotine • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction
Gene Ontology	Cellular Component	• postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • presynapse • presynaptic membrane • cell projection • neuron projection • plasma membrane bounded cell projection • cell leading edge • leading edge membrane • somatodendritic compartment • neuron projection membrane • dendrite membrane • dendrite • dendritic tree • cell projection membrane • transport vesicle membrane • bounding membrane of organelle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • organelle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus • neuron spine • dendritic spine • spine apparatus • opioid peptide activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • defense response • response to stress • extracellular region • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>8F7S_nogp_Chain_R S L A L A I A I T A L Y S A V C A V G L L G N V L V M F V I V R Y T K M K T A T N I Y I F S L A L A G A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y S M F T S I F T L T M M C V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P R D G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V V A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y I N S S L N P V L Y A F L D E N F K R C F R Q L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5

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