psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A98	5.81	Yes	No	0	0	6
2	L:L:?1	R:R:D128	3	Yes	No	1	0	5
3	L:L:?1	R:R:Y129	16.42	Yes	No	0	0	5
4	L:L:?1	R:R:M132	7.29	Yes	No	1	0	8
5	L:L:?1	R:R:S135	6.64	Yes	No	0	0	9
6	L:L:?1	R:R:K214	7.28	Yes	Yes	1	0	5
7	L:L:?1	R:R:V217	3.29	Yes	No	0	0	5
8	L:L:?1	R:R:W274	9.23	Yes	Yes	1	0	8
9	L:L:?1	R:R:I277	5.26	Yes	No	1	0	5
10	L:L:?1	R:R:H278	4.74	Yes	Yes	1	0	7
11	L:L:?1	R:R:V281	9.88	Yes	No	1	0	6
12	L:L:?1	R:R:W284	6.72	Yes	No	0	0	4
13	L:L:?1	R:R:I304	3.16	Yes	No	1	0	5
14	L:L:?1	R:R:Y308	8.64	Yes	Yes	1	0	7
15	L:L:?1	R:R:S311	8.85	Yes	No	0	0	9
16	R:R:L48	R:R:S45	7.51	No	No	0	2	6
17	R:R:I50	R:R:T53	3.04	No	No	0	5	6
18	R:R:I52	R:R:Y56	3.63	No	Yes	0	5	7
19	R:R:I52	R:R:Y109	12.09	No	Yes	0	5	4
20	R:R:L55	R:R:V59	2.98	No	No	0	5	7
21	R:R:A305	R:R:L55	3.15	No	No	0	5	5
22	R:R:L102	R:R:Y56	4.69	Yes	Yes	0	7	7
23	R:R:S106	R:R:Y56	6.36	No	Yes	0	6	7
24	R:R:H301	R:R:Y56	9.8	Yes	Yes	0	4	7
25	R:R:I304	R:R:Y56	7.25	No	Yes	0	5	7
26	R:R:A305	R:R:Y56	2.67	No	Yes	0	5	7
27	R:R:C60	R:R:T99	3.38	No	No	0	6	6
28	R:R:C60	R:R:L102	6.35	No	Yes	0	6	7
29	R:R:S312	R:R:V62	6.46	No	No	0	7	4
30	R:R:G63	R:R:S312	3.71	No	No	0	8	7
31	R:R:L64	R:R:V68	2.98	No	No	0	6	4
32	R:R:D95	R:R:N67	4.04	Yes	No	0	9	9
33	R:R:A96	R:R:N67	4.69	No	No	0	7	9
34	R:R:N67	R:R:P315	6.52	No	No	0	9	9
35	R:R:A92	R:R:V70	3.39	No	No	0	9	8
36	R:R:V70	R:R:Y318	5.05	No	Yes	0	8	9
37	R:R:F89	R:R:M71	4.98	Yes	No	0	6	7
38	R:R:F72	R:R:R76	10.69	No	No	0	4	5
39	R:R:F72	R:R:Y77	3.09	No	No	0	4	5
40	R:R:G73	R:R:Y77	5.79	No	No	0	8	5
41	R:R:I74	R:R:N85	5.66	No	No	0	7	8
42	R:R:R76	R:R:V75	2.62	No	No	0	5	3
43	R:R:K81	R:R:T78	4.5	No	No	0	6	6
44	R:R:N85	R:R:T78	2.92	No	No	0	8	6
45	R:R:I86	R:R:M80	2.92	No	No	0	6	7
46	R:R:F89	R:R:M80	9.95	Yes	No	0	6	7
47	R:R:K81	R:R:T82	4.5	No	No	0	6	7
48	R:R:N85	R:R:T82	5.85	No	No	0	8	7
49	R:R:I88	R:R:T84	3.04	No	No	0	8	8
50	R:R:A165	R:R:I86	3.25	No	No	0	7	6
51	R:R:I86	R:R:K166	5.82	No	No	0	6	3
52	R:R:M141	R:R:Y87	8.38	No	Yes	2	7	7
53	R:R:M142	R:R:Y87	3.59	No	Yes	0	9	7
54	R:R:D145	R:R:Y87	3.45	No	Yes	0	8	7
55	R:R:I168	R:R:Y87	4.84	No	Yes	2	5	7
56	R:R:N169	R:R:Y87	4.65	No	Yes	2	7	7
57	R:R:I88	R:R:M142	2.92	No	No	0	8	9
58	R:R:I88	R:R:Y318	10.88	No	Yes	0	8	9
59	R:R:F89	R:R:N90	3.62	Yes	No	0	6	9
60	R:R:N169	R:R:N90	17.71	No	No	2	7	9
61	R:R:N90	R:R:W173	10.17	No	Yes	2	9	9
62	R:R:D95	R:R:L91	2.71	Yes	Yes	4	9	9
63	R:R:L91	R:R:T138	4.42	Yes	No	0	9	8
64	R:R:L139	R:R:L91	2.77	No	Yes	0	8	9
65	R:R:L91	R:R:N314	4.12	Yes	No	4	9	9
66	R:R:L93	R:R:W173	3.42	No	Yes	0	6	9
67	R:R:A94	R:R:T134	3.36	No	No	0	8	8
68	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
69	R:R:D95	R:R:S311	7.36	Yes	No	0	9	9
70	R:R:D95	R:R:N314	4.04	Yes	No	4	9	9
71	R:R:L97	R:R:N131	6.87	No	No	0	7	8
72	R:R:A98	R:R:N131	4.69	No	No	0	6	8
73	R:R:F104	R:R:T101	3.89	No	Yes	0	6	7
74	R:R:Q105	R:R:T101	7.09	No	Yes	0	5	7
75	R:R:D128	R:R:T101	8.67	No	Yes	1	5	7
76	R:R:T101	R:R:Y308	7.49	Yes	Yes	1	7	7
77	R:R:L102	R:R:Y308	15.24	Yes	Yes	0	7	7
78	R:R:F104	R:R:F116	3.22	No	Yes	0	6	7
79	R:R:F104	R:R:V124	5.24	No	No	0	6	5
80	R:R:K108	R:R:W114	3.48	No	Yes	0	4	8
81	R:R:H301	R:R:K108	3.93	Yes	No	0	4	4
82	R:R:A298	R:R:Y109	2.67	No	Yes	0	1	4
83	R:R:H301	R:R:Y109	20.69	Yes	Yes	0	4	4
84	R:R:M111	R:R:T113	3.01	No	No	0	4	4
85	R:R:T113	R:R:V196	6.35	No	No	0	4	4
86	R:R:P115	R:R:W114	2.7	No	Yes	5	3	8
87	R:R:F116	R:R:W114	12.03	Yes	Yes	5	7	8
88	R:R:G117	R:R:W114	2.81	No	Yes	0	7	8
89	R:R:C121	R:R:W114	9.14	No	Yes	0	9	8
90	R:R:V124	R:R:W114	4.9	No	Yes	0	5	8
91	R:R:F116	R:R:P115	20.23	Yes	No	5	7	3
92	R:R:F116	R:R:L120	6.09	Yes	No	0	7	6
93	R:R:E118	R:R:V188	8.56	No	No	0	4	4
94	R:R:E118	R:R:T189	8.47	No	No	0	4	4
95	R:R:C121	R:R:T189	3.38	No	No	0	9	4
96	R:R:C121	R:R:C198	7.28	No	No	0	9	9
97	R:R:I183	R:R:S126	3.1	No	No	0	4	6
98	R:R:M184	R:R:S126	6.13	No	No	0	4	6
99	R:R:I127	R:R:N131	4.25	No	No	0	5	8
100	R:R:D128	R:R:Y308	3.45	No	Yes	1	5	7
101	R:R:I183	R:R:Y129	15.71	No	No	0	4	5
102	R:R:T134	R:R:Y130	7.49	No	No	2	8	5
103	R:R:W173	R:R:Y130	9.65	Yes	No	2	9	5
104	R:R:A176	R:R:Y130	2.67	No	No	0	8	5
105	R:R:M132	R:R:W274	6.98	No	Yes	1	8	8
106	R:R:F133	R:R:F137	8.57	Yes	No	0	7	6
107	R:R:F133	R:R:V179	3.93	Yes	No	0	7	4
108	R:R:F133	R:R:V217	2.62	Yes	No	0	7	5
109	R:R:A221	R:R:F133	2.77	No	Yes	0	6	7
110	R:R:T134	R:R:W173	14.55	No	Yes	2	8	9
111	R:R:I136	R:R:P225	3.39	No	No	0	7	8
112	R:R:F270	R:R:I136	6.28	No	No	1	9	7
113	R:R:I136	R:R:W274	4.7	No	Yes	1	7	8
114	R:R:F137	R:R:I172	6.28	No	No	0	6	6
115	R:R:P225	R:R:T140	3.5	No	No	0	8	7
116	R:R:I228	R:R:T140	4.56	No	No	0	7	7
117	R:R:I168	R:R:M141	5.83	No	No	2	5	7
118	R:R:I172	R:R:M141	2.92	No	No	0	6	7
119	R:R:M142	R:R:R146	3.72	No	No	0	9	9
120	R:R:S143	R:R:V144	3.23	Yes	No	3	9	7
121	R:R:I229	R:R:S143	6.19	No	Yes	0	8	9
122	R:R:C232	R:R:S143	5.16	No	Yes	3	8	9
123	R:R:S143	R:R:Y233	5.09	Yes	Yes	0	9	8
124	R:R:C232	R:R:V144	3.42	No	No	3	8	7
125	R:R:D145	R:R:R160	16.68	No	No	0	8	6
126	R:R:R146	R:R:Y233	9.26	No	Yes	0	9	8
127	R:R:I148	R:R:Y147	3.63	No	Yes	3	5	8
128	R:R:C151	R:R:Y147	6.72	No	Yes	0	7	8
129	R:R:H152	R:R:Y147	6.53	No	Yes	3	6	8
130	R:R:C232	R:R:Y147	6.72	No	Yes	3	8	8
131	R:R:L235	R:R:Y147	7.03	No	Yes	0	4	8
132	R:R:H152	R:R:I148	3.98	No	No	3	6	5
133	R:R:A149	R:R:R160	6.91	No	No	0	8	6
134	R:R:M236	R:R:V150	6.09	No	No	0	8	8
135	R:R:R239	R:R:V150	2.62	Yes	No	0	5	8
136	R:R:L240	R:R:V150	2.98	No	No	0	8	8
137	R:R:C151	R:R:R239	2.79	No	Yes	0	7	5
138	R:R:A156	R:R:R160	2.77	No	No	0	5	6
139	R:R:P162	R:R:T161	3.5	No	No	0	3	7
140	R:R:K164	R:R:T161	4.5	No	No	0	4	7
141	R:R:N169	R:R:W173	4.52	No	Yes	2	7	9
142	R:R:P182	R:R:V181	3.53	No	No	0	7	4
143	R:R:I183	R:R:L200	2.85	No	Yes	0	4	4
144	R:R:L200	R:R:M186	5.65	Yes	Yes	6	4	4
145	R:R:F202	R:R:M186	3.73	Yes	Yes	6	6	4
146	R:R:M186	R:R:P203	3.35	Yes	No	0	4	6
147	R:R:Q201	R:R:V188	4.3	No	No	0	4	4
148	R:R:P191	R:R:V196	5.3	No	No	0	1	4
149	R:R:M199	R:R:V197	3.04	No	No	0	4	4
150	R:R:F202	R:R:L200	7.31	Yes	Yes	6	6	4
151	R:R:F202	R:R:S206	2.64	Yes	No	0	6	3
152	R:R:F202	R:R:W209	3.01	Yes	No	0	6	4
153	R:R:D210	R:R:F202	9.55	No	Yes	0	4	6
154	R:R:F202	R:R:T213	9.08	Yes	No	0	6	6
155	R:R:P205	R:R:S204	3.56	Yes	No	0	2	4
156	R:R:P205	R:R:W207	4.05	Yes	No	7	2	3
157	R:R:P205	R:R:Y208	5.56	Yes	No	7	2	3
158	R:R:P205	R:R:W209	2.7	Yes	No	0	2	4
159	R:R:W207	R:R:Y208	4.82	No	No	7	3	3
160	R:R:V212	R:R:Y208	7.57	No	No	0	4	3
161	R:R:D210	R:R:K214	13.83	No	Yes	0	4	5
162	R:R:K214	R:R:V281	4.55	Yes	No	1	5	6
163	R:R:K214	R:R:T285	4.5	Yes	No	0	5	4
164	R:R:F218	R:R:F222	5.36	Yes	No	1	5	8
165	R:R:F218	R:R:V223	3.93	Yes	No	0	5	4
166	R:R:F218	R:R:H278	4.53	Yes	Yes	1	5	7
167	R:R:A275	R:R:F222	4.16	No	No	0	6	8
168	R:R:F222	R:R:H278	3.39	No	Yes	1	8	7
169	R:R:P225	R:R:V224	3.53	No	No	0	8	5
170	R:R:I226	R:R:V271	3.07	No	No	0	6	6
171	R:R:L235	R:R:V231	2.98	No	No	0	4	4
172	R:R:V263	R:R:Y233	16.4	No	Yes	0	7	8
173	R:R:L237	R:R:R241	3.64	Yes	No	0	5	4
174	R:R:L237	R:R:T260	5.9	Yes	Yes	0	5	7
175	R:R:R239	R:R:V243	3.92	Yes	No	0	5	6
176	R:R:L240	R:R:V243	2.98	No	No	0	8	6
177	R:R:I259	R:R:L240	2.85	No	No	0	8	8
178	R:R:L256	R:R:R241	3.64	No	No	0	6	4
179	R:R:L245	R:R:S255	3	No	No	0	3	5
180	R:R:K252	R:R:L246	2.82	No	No	0	2	2
181	R:R:K250	R:R:R254	8.66	No	No	0	2	4
182	R:R:K252	R:R:L256	8.46	No	No	0	2	6
183	R:R:L256	R:R:T260	2.95	No	Yes	0	6	7
184	R:R:R257	R:R:T260	3.88	No	Yes	0	5	7
185	R:R:R258	R:R:R261	6.4	Yes	No	8	7	6
186	R:R:L321	R:R:R258	3.64	Yes	Yes	8	6	7
187	R:R:E323	R:R:R258	12.79	No	Yes	0	4	7
188	R:R:K326	R:R:R258	3.71	No	Yes	0	8	7
189	R:R:L321	R:R:R261	3.64	Yes	No	8	6	6
190	R:R:L321	R:R:M262	9.9	Yes	No	0	6	8
191	R:R:L317	R:R:V265	2.98	No	No	0	8	6
192	R:R:F270	R:R:W274	4.01	No	Yes	1	9	8
193	R:R:C273	R:R:N310	7.87	No	Yes	0	8	9
194	R:R:H278	R:R:W274	4.23	Yes	Yes	1	7	8
195	R:R:N310	R:R:W274	6.78	Yes	Yes	0	9	8
196	R:R:C303	R:R:I277	4.91	No	No	0	6	5
197	R:R:I277	R:R:I304	2.94	No	No	1	5	5
198	R:R:F280	R:R:V283	2.62	Yes	No	0	5	4
199	R:R:A299	R:R:F280	2.77	No	Yes	0	5	5
200	R:R:F280	R:R:L300	3.65	Yes	No	0	5	5
201	R:R:R291	R:R:W284	10	No	No	0	1	4
202	R:R:L286	R:R:T285	2.95	No	No	0	4	4
203	R:R:D290	R:R:I289	7	No	No	0	3	1
204	R:R:D290	R:R:D293	10.65	No	Yes	0	3	3
205	R:R:D293	R:R:P294	9.66	Yes	No	0	3	2
206	R:R:D293	R:R:L295	2.71	Yes	No	0	3	2
207	R:R:D293	R:R:V296	2.92	Yes	No	0	3	5
208	R:R:H301	R:R:V297	2.77	Yes	No	0	4	4
209	R:R:N310	R:R:N314	5.45	Yes	No	0	9	9
210	R:R:L313	R:R:L317	4.15	No	No	0	7	8
211	R:R:D322	R:R:Y318	6.9	No	Yes	0	8	9
212	R:R:F325	R:R:Y318	9.28	No	Yes	0	8	9
213	R:R:D322	R:R:N324	2.69	No	No	0	8	7
214	R:R:C328	R:R:N324	3.15	No	No	0	6	7
215	R:R:C328	R:R:R327	4.18	No	No	0	6	5
216	R:R:V267	R:R:Y233	2.52	No	Yes	0	7	8
217	R:R:F89	R:R:I74	2.51	Yes	No	0	6	7
218	R:R:F159	R:R:I148	2.51	No	No	0	3	5
219	R:R:F270	R:R:I226	2.51	No	No	0	9	6
220	R:R:F159	R:R:K164	2.48	No	No	0	3	4
221	R:R:F320	R:R:K326	2.48	No	No	0	7	8
222	R:R:F218	R:R:L219	2.44	Yes	No	0	5	4
223	R:R:I289	R:R:W284	2.35	No	No	0	1	4
224	R:R:G66	R:R:P315	2.03	No	No	0	7	9
225	R:R:G180	R:R:P182	2.03	No	No	0	7	7
226	R:R:C303	R:R:P276	1.88	No	No	0	6	9
227	R:R:G248	R:R:S247	1.86	No	No	0	2	3
228	R:R:A165	R:R:A83	1.79	No	No	0	7	5
229	R:R:P294	R:R:S45	1.78	No	No	0	2	6
230	R:R:G66	R:R:L65	1.71	No	No	0	7	4
231	R:R:G66	R:R:L69	1.71	No	No	0	7	6
232	R:R:C216	R:R:V212	1.71	No	No	0	3	4
233	R:R:G234	R:R:L237	1.71	No	Yes	0	3	5
234	R:R:C273	R:R:V272	1.71	No	No	0	8	6
235	R:R:G307	R:R:L306	1.71	No	No	0	7	7
236	R:R:A309	R:R:V59	1.7	No	No	0	5	7
237	R:R:A195	R:R:V197	1.7	No	No	0	2	4
238	R:R:G307	R:R:N310	1.7	No	Yes	0	7	9
239	R:R:A163	R:R:T161	1.68	No	No	0	4	7
240	R:R:L102	R:R:P103	1.64	Yes	No	0	7	8
241	R:R:A51	R:R:I52	1.62	No	No	0	4	5
242	R:R:S177	R:R:V181	1.62	No	No	0	4	4
243	R:R:A187	R:R:K122	1.61	No	No	0	4	7
244	R:R:S100	R:R:T101	1.6	No	Yes	0	5	7
245	R:R:V181	R:R:V185	1.6	No	No	0	4	4
246	R:R:V265	R:R:V266	1.6	No	No	0	6	7
247	R:R:C171	R:R:L167	1.59	No	No	0	3	3
248	R:R:T230	R:R:V267	1.59	No	No	0	4	7
249	R:R:A49	R:R:L110	1.58	No	No	0	4	4
250	R:R:A187	R:R:L200	1.58	No	Yes	0	4	4
251	R:R:A269	R:R:L313	1.58	No	No	0	6	7
252	R:R:I74	R:R:V75	1.54	No	No	0	7	3
253	R:R:I170	R:R:V174	1.54	No	No	0	4	4
254	R:R:H152	R:R:P153	1.53	No	No	0	6	8
255	R:R:M186	R:R:V185	1.52	Yes	No	0	4	4
256	R:R:I215	R:R:T211	1.52	No	No	0	4	2
257	R:R:L46	R:R:S44	1.5	No	No	0	2	4
258	R:R:L125	R:R:V124	1.49	No	No	0	5	5
259	R:R:L237	R:R:V263	1.49	Yes	No	0	5	7
260	R:R:L245	R:R:V243	1.49	No	No	0	3	6
261	R:R:L321	R:R:V265	1.49	Yes	No	0	6	6
262	R:R:L286	R:R:V287	1.49	No	No	0	4	3
263	R:R:I215	R:R:I282	1.47	No	No	0	4	6
264	R:R:L227	R:R:T230	1.47	No	No	0	4	4
265	R:R:L264	R:R:T260	1.47	No	Yes	0	5	7
266	R:R:K79	R:R:K81	1.44	No	No	0	5	6
267	R:R:P191	R:R:R190	1.44	No	No	0	1	3
268	R:R:I282	R:R:L286	1.43	No	No	0	6	4
269	R:R:L110	R:R:M111	1.41	No	No	0	4	4
270	R:R:A319	R:R:F325	1.39	No	No	0	7	8
271	R:R:L302	R:R:L55	1.38	No	No	0	5	5
272	R:R:A195	R:R:R292	1.38	No	No	0	2	1
273	R:R:A49	R:R:Y109	1.33	No	Yes	0	4	4
274	R:R:E251	R:R:L245	1.33	No	No	0	3	3
275	R:R:R239	R:R:S242	1.32	Yes	No	0	5	4
276	R:R:R254	R:R:S255	1.32	No	No	0	4	5
277	R:R:F280	R:R:V296	1.31	Yes	No	0	5	5
278	R:R:V266	R:R:Y233	1.26	No	Yes	0	7	8
279	R:R:F220	R:R:L219	1.22	No	No	0	4	4
280	R:R:L238	R:R:R241	1.21	No	No	0	4	4
281	R:R:R291	R:R:R292	1.07	No	No	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.08067	15	1	0
2	R:R:Y56	5.73333	6	0	7
3	R:R:Y87	4.982	5	2	7
4	R:R:F89	5.265	4	0	6
5	R:R:L91	3.505	4	4	9
6	R:R:D95	4.218	5	4	9
7	R:R:T101	5.748	5	1	7
8	R:R:L102	6.98	4	0	7
9	R:R:Y109	9.195	4	0	4
10	R:R:W114	5.84333	6	5	8
11	R:R:F116	10.3925	4	5	7
12	R:R:F133	4.4725	4	0	7
13	R:R:S143	4.9175	4	3	9
14	R:R:Y147	6.126	5	3	8
15	R:R:W173	8.462	5	2	9
16	R:R:M186	3.5625	4	6	4
17	R:R:L200	4.3475	4	6	4
18	R:R:F202	5.88667	6	6	6
19	R:R:P205	3.9675	4	7	2
20	R:R:K214	7.54	4	1	5
21	R:R:F218	4.065	4	1	5
22	R:R:Y233	6.906	5	0	8
23	R:R:L237	3.185	4	0	5
24	R:R:R239	2.6625	4	0	5
25	R:R:R258	6.635	4	8	7
26	R:R:T260	3.55	4	0	7
27	R:R:W274	5.98833	6	1	8
28	R:R:H278	4.2225	4	1	7
29	R:R:F280	2.5875	4	0	5
30	R:R:D293	6.485	4	0	3
31	R:R:H301	9.2975	4	0	4
32	R:R:Y308	8.705	4	1	7
33	R:R:N310	5.45	4	0	9
34	R:R:Y318	8.0275	4	0	9
35	R:R:L321	4.6675	4	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W284	22.7532	6.72	Yes	No	0	0	4
2	R:R:I289	R:R:W284	15.6998	2.35	No	No	0	1	4
3	R:R:D290	R:R:I289	14.4263	7	No	No	0	3	1
4	R:R:D290	R:R:D293	13.1442	10.65	No	Yes	0	3	3
5	L:L:?1	R:R:I304	37.0006	3.16	Yes	No	1	0	5
6	R:R:I304	R:R:Y56	36.7195	7.25	No	Yes	0	5	7
7	R:R:I52	R:R:Y56	11.5172	3.63	No	Yes	0	5	7
8	R:R:H301	R:R:Y56	20.6619	9.8	Yes	Yes	0	4	7
9	L:L:?1	R:R:Y308	28.4777	8.64	Yes	Yes	1	0	7
10	L:L:?1	R:R:S135	14.6903	6.64	Yes	No	0	0	9
11	R:R:D95	R:R:S135	13.5616	2.94	Yes	No	0	9	9
12	L:L:?1	R:R:S311	14.6989	8.85	Yes	No	0	0	9
13	R:R:D95	R:R:S311	13.5616	7.36	Yes	No	0	9	9
14	R:R:D95	R:R:N67	15.457	4.04	Yes	No	0	9	9
15	R:R:N67	R:R:P315	10.3373	6.52	No	No	0	9	9
16	L:L:?1	R:R:V217	100	3.29	Yes	No	0	0	5
17	R:R:F133	R:R:V217	99.6465	2.62	Yes	No	0	7	5
18	R:R:F133	R:R:F137	98.3857	8.57	Yes	No	0	7	6
19	R:R:F137	R:R:I172	97.947	6.28	No	No	0	6	6
20	R:R:I172	R:R:M141	97.4998	2.92	No	No	0	6	7
21	R:R:M141	R:R:Y87	96.1283	8.38	No	Yes	2	7	7
22	R:R:M142	R:R:Y87	76.429	3.59	No	Yes	0	9	7
23	R:R:I88	R:R:M142	14.5072	2.92	No	No	0	8	9
24	R:R:I88	R:R:Y318	11.9942	10.88	No	Yes	0	8	9
25	R:R:N169	R:R:Y87	35.0584	4.65	No	Yes	2	7	7
26	R:R:N169	R:R:N90	26.3821	17.71	No	No	2	7	9
27	R:R:F89	R:R:N90	25.722	3.62	Yes	No	0	6	9
28	R:R:F89	R:R:I74	17.1054	2.51	Yes	No	0	6	7
29	L:L:?1	R:R:W274	18.2213	9.23	Yes	Yes	1	0	8
30	L:L:?1	R:R:D128	24.7381	3	Yes	No	1	0	5
31	R:R:D128	R:R:T101	23.8223	8.67	No	Yes	1	5	7
32	R:R:F104	R:R:T101	42.2438	3.89	No	Yes	0	6	7
33	R:R:T101	R:R:Y308	24.2951	7.49	Yes	Yes	1	7	7
34	R:R:F104	R:R:F116	21.3008	3.22	No	Yes	0	6	7
35	R:R:F104	R:R:V124	19.1328	5.24	No	No	0	6	5
36	R:R:H301	R:R:K108	10.2351	3.93	Yes	No	0	4	4
37	R:R:F116	R:R:W114	15.8233	12.03	Yes	Yes	5	7	8
38	R:R:V124	R:R:W114	15.6274	4.9	No	Yes	0	5	8
39	R:R:A49	R:R:Y109	15.1333	1.33	No	Yes	0	4	4
40	R:R:A49	R:R:L110	13.1016	1.58	No	No	0	4	4
41	R:R:L110	R:R:M111	10.9422	1.41	No	No	0	4	4
42	R:R:C121	R:R:W114	29.8961	9.14	No	Yes	0	9	8
43	R:R:C121	R:R:T189	19.9634	3.38	No	No	0	9	4
44	R:R:E118	R:R:T189	14.9842	8.47	No	No	0	4	4
45	L:L:?1	R:R:Y129	16.705	16.42	Yes	No	0	0	5
46	R:R:I183	R:R:Y129	15.555	15.71	No	No	0	4	5
47	R:R:M142	R:R:R146	66.722	3.72	No	No	0	9	9
48	R:R:R146	R:R:Y233	65.9255	9.26	No	Yes	0	9	8
49	R:R:S143	R:R:Y233	36.8302	5.09	Yes	Yes	0	9	8
50	R:R:C232	R:R:S143	33.3291	5.16	No	Yes	3	8	9
51	R:R:C232	R:R:Y147	32.2983	6.72	No	Yes	3	8	8
52	R:R:C151	R:R:Y147	19.2435	6.72	No	Yes	0	7	8
53	R:R:C151	R:R:R239	17.9871	2.79	No	Yes	0	7	5
54	R:R:R239	R:R:V243	10.4822	3.92	Yes	No	0	5	6
55	R:R:I183	R:R:L200	12.2412	2.85	No	Yes	0	4	4
56	R:R:M186	R:R:V185	12.6033	1.52	Yes	No	0	4	4
57	R:R:V181	R:R:V185	10.0988	1.6	No	No	0	4	4
58	L:L:?1	R:R:K214	29.9429	7.28	Yes	Yes	1	0	5
59	R:R:D210	R:R:K214	22.3358	13.83	No	Yes	0	4	5
60	R:R:D210	R:R:F202	21.1943	9.55	No	Yes	0	4	6
61	R:R:V263	R:R:Y233	18.1659	16.4	No	Yes	0	7	8
62	R:R:L237	R:R:V263	17.0287	1.49	Yes	No	0	5	7
63	R:R:V266	R:R:Y233	15.3207	1.26	No	Yes	0	7	8
64	R:R:V265	R:R:V266	14.175	1.6	No	No	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A98	5.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:D128	3	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y129	16.42	1	Yes	No	0	5	0	1
L:L:?1	R:R:M132	7.29	1	Yes	No	0	8	0	1
L:L:?1	R:R:S135	6.64	1	Yes	No	0	9	0	1
L:L:?1	R:R:K214	7.28	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V217	3.29	1	Yes	No	0	5	0	1
L:L:?1	R:R:W274	9.23	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I277	5.26	1	Yes	No	0	5	0	1
L:L:?1	R:R:H278	4.74	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V281	9.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:W284	6.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:I304	3.16	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y308	8.64	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S311	8.85	1	Yes	No	0	9	0	1
R:R:L102	R:R:Y56	4.69	0	Yes	Yes	7	7	2	2
R:R:I304	R:R:Y56	7.25	1	No	Yes	5	7	1	2
R:R:D95	R:R:S135	2.94	4	Yes	No	9	9	2	1
R:R:D95	R:R:S311	7.36	4	Yes	No	9	9	2	1
R:R:A98	R:R:N131	4.69	0	No	No	6	8	1	2
R:R:D128	R:R:T101	8.67	1	No	Yes	5	7	1	2
R:R:T101	R:R:Y308	7.49	1	Yes	Yes	7	7	2	1
R:R:L102	R:R:Y308	15.24	0	Yes	Yes	7	7	2	1
R:R:D128	R:R:Y308	3.45	1	No	Yes	5	7	1	1
R:R:I183	R:R:Y129	15.71	0	No	No	4	5	2	1
R:R:M132	R:R:W274	6.98	1	No	Yes	8	8	1	1
R:R:F133	R:R:V217	2.62	0	Yes	No	7	5	2	1
R:R:F270	R:R:I136	6.28	1	No	No	9	7	2	2
R:R:I136	R:R:W274	4.7	1	No	Yes	7	8	2	1
R:R:D210	R:R:K214	13.83	0	No	Yes	4	5	2	1
R:R:K214	R:R:V281	4.55	1	Yes	No	5	6	1	1
R:R:K214	R:R:T285	4.5	1	Yes	No	5	4	1	2
R:R:F218	R:R:F222	5.36	1	Yes	No	5	8	2	2
R:R:F218	R:R:H278	4.53	1	Yes	Yes	5	7	2	1
R:R:F222	R:R:H278	3.39	1	No	Yes	8	7	2	1
R:R:F270	R:R:W274	4.01	1	No	Yes	9	8	2	1
R:R:H278	R:R:W274	4.23	1	Yes	Yes	7	8	1	1
R:R:N310	R:R:W274	6.78	0	Yes	Yes	9	8	2	1
R:R:C303	R:R:I277	4.91	0	No	No	6	5	2	1
R:R:I277	R:R:I304	2.94	1	No	No	5	5	1	1
R:R:R291	R:R:W284	10	0	No	No	1	4	2	1
R:R:I289	R:R:W284	2.35	0	No	No	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9CGJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	261
Number of Links	281
Number of Hubs	35
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	47070
Length Of Smallest Path	3
Average Path Length	13.6227
Length of Longest Path	31
Minimum Path Strength	1.225
Average Path Strength	5.71088
Maximum Path Strength	16.065
Minimum Path Correlation	0.7
Average Path Correlation	0.920436
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.6494
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.6522
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>9CGJ_nogp_Chain_R S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F K R C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9YDP	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDP (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	-		1.95	2025-12-10	10.1101/2025.10.16.682975
	9YDQ	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614	chim(NtGi1L-Gs-CtGi1)/β1/γ2	1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDQ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3614		1.94	2025-12-10	10.1101/2025.10.16.682975
	9YDR	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983	chim(NtGi1L-Gs-CtGi1)/β1/γ2	2.14	2025-12-10	10.1101/2025.10.16.682975
	9YDR (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	DADLE	MIPS3983		2.14	2025-12-10	10.1101/2025.10.16.682975
	8Y71	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187	Gi1/β1/γ2	2.97	2026-01-07	To be published
	8Y71 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	A1D6F	BMS986187		2.97	2026-01-07	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9CGJ_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.