psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A98	4.3	Yes	No	0	0	6
2	L:L:?1	R:R:Y129	12.17	Yes	No	0	0	5
3	L:L:?1	R:R:M132	5.41	Yes	No	1	0	8
4	L:L:?1	R:R:S135	4.92	Yes	No	0	0	9
5	L:L:?1	R:R:K214	5.39	Yes	Yes	1	0	5
6	L:L:?1	R:R:V217	2.44	Yes	No	0	0	5
7	L:L:?1	R:R:W274	6.85	Yes	Yes	1	0	8
8	L:L:?1	R:R:I277	3.9	Yes	No	0	0	5
9	L:L:?1	R:R:H278	3.51	Yes	Yes	1	0	7
10	L:L:?1	R:R:V281	7.33	Yes	No	1	0	6
11	L:L:?1	R:R:W284	4.98	Yes	No	0	0	4
12	L:L:?1	R:R:Y308	6.41	Yes	Yes	1	0	7
13	L:L:?1	R:R:S311	6.56	Yes	No	0	0	9
14	R:R:L48	R:R:S45	7.51	No	No	0	2	6
15	R:R:I50	R:R:T53	3.04	No	No	0	5	6
16	R:R:I52	R:R:Y56	3.63	No	Yes	0	5	7
17	R:R:I52	R:R:Y109	12.09	No	Yes	0	5	4
18	R:R:L55	R:R:V59	2.98	No	No	0	5	7
19	R:R:A305	R:R:L55	3.15	No	No	0	5	5
20	R:R:L102	R:R:Y56	4.69	Yes	Yes	0	7	7
21	R:R:S106	R:R:Y56	6.36	No	Yes	0	6	7
22	R:R:H301	R:R:Y56	9.8	Yes	Yes	0	4	7
23	R:R:I304	R:R:Y56	7.25	No	Yes	0	5	7
24	R:R:A305	R:R:Y56	2.67	No	Yes	0	5	7
25	R:R:C60	R:R:T99	3.38	No	No	0	6	6
26	R:R:C60	R:R:L102	6.35	No	Yes	0	6	7
27	R:R:S312	R:R:V62	6.46	No	No	0	7	4
28	R:R:G63	R:R:S312	3.71	No	No	0	8	7
29	R:R:L64	R:R:V68	2.98	No	No	0	6	4
30	R:R:D95	R:R:N67	4.04	Yes	No	0	9	9
31	R:R:A96	R:R:N67	4.69	No	No	0	7	9
32	R:R:N67	R:R:P315	6.52	No	No	0	9	9
33	R:R:A92	R:R:V70	3.39	No	No	0	9	8
34	R:R:V70	R:R:Y318	5.05	No	Yes	0	8	9
35	R:R:F89	R:R:M71	4.98	Yes	No	0	6	7
36	R:R:F72	R:R:R76	10.69	No	No	0	4	5
37	R:R:F72	R:R:Y77	3.09	No	No	0	4	5
38	R:R:G73	R:R:Y77	5.79	No	No	0	8	5
39	R:R:I74	R:R:N85	5.66	No	No	0	7	8
40	R:R:F89	R:R:I74	2.51	Yes	No	0	6	7
41	R:R:R76	R:R:V75	2.62	No	No	0	5	3
42	R:R:K81	R:R:T78	4.5	No	No	0	6	6
43	R:R:N85	R:R:T78	2.92	No	No	0	8	6
44	R:R:I86	R:R:M80	2.92	No	No	0	6	7
45	R:R:F89	R:R:M80	9.95	Yes	No	0	6	7
46	R:R:K81	R:R:T82	4.5	No	No	0	6	7
47	R:R:N85	R:R:T82	5.85	No	No	0	8	7
48	R:R:I88	R:R:T84	3.04	No	No	0	8	8
49	R:R:A165	R:R:I86	3.25	No	No	0	7	6
50	R:R:I86	R:R:K166	5.82	No	No	0	6	3
51	R:R:M141	R:R:Y87	8.38	No	Yes	2	7	7
52	R:R:M142	R:R:Y87	3.59	No	Yes	0	9	7
53	R:R:D145	R:R:Y87	3.45	No	Yes	0	8	7
54	R:R:I168	R:R:Y87	4.84	No	Yes	2	5	7
55	R:R:N169	R:R:Y87	4.65	No	Yes	2	7	7
56	R:R:I88	R:R:M142	2.92	No	No	0	8	9
57	R:R:I88	R:R:Y318	10.88	No	Yes	0	8	9
58	R:R:F89	R:R:N90	3.62	Yes	No	0	6	9
59	R:R:F89	R:R:L93	2.44	Yes	No	0	6	6
60	R:R:N169	R:R:N90	17.71	No	No	2	7	9
61	R:R:N90	R:R:W173	10.17	No	Yes	2	9	9
62	R:R:D95	R:R:L91	2.71	Yes	Yes	5	9	9
63	R:R:L91	R:R:T138	4.42	Yes	No	0	9	8
64	R:R:L139	R:R:L91	2.77	No	Yes	0	8	9
65	R:R:L91	R:R:N314	4.12	Yes	No	5	9	9
66	R:R:L93	R:R:W173	3.42	No	Yes	0	6	9
67	R:R:A94	R:R:T134	3.36	No	No	2	8	8
68	R:R:A94	R:R:W173	2.59	No	Yes	2	8	9
69	R:R:D95	R:R:S135	2.94	Yes	No	0	9	9
70	R:R:D95	R:R:S311	7.36	Yes	No	0	9	9
71	R:R:D95	R:R:N314	4.04	Yes	No	5	9	9
72	R:R:L97	R:R:N131	6.87	No	No	0	7	8
73	R:R:A98	R:R:N131	4.69	No	No	0	6	8
74	R:R:F104	R:R:T101	3.89	No	Yes	0	6	7
75	R:R:Q105	R:R:T101	7.09	No	Yes	1	5	7
76	R:R:D128	R:R:T101	8.67	No	Yes	1	5	7
77	R:R:T101	R:R:Y308	7.49	Yes	Yes	1	7	7
78	R:R:L102	R:R:Y308	15.24	Yes	Yes	0	7	7
79	R:R:F104	R:R:F116	3.22	No	Yes	0	6	7
80	R:R:F104	R:R:V124	5.24	No	No	0	6	5
81	R:R:D128	R:R:Q105	2.61	No	No	1	5	5
82	R:R:K108	R:R:W114	3.48	No	Yes	0	4	8
83	R:R:H301	R:R:K108	3.93	Yes	No	0	4	4
84	R:R:V297	R:R:Y109	2.52	No	Yes	4	4	4
85	R:R:A298	R:R:Y109	2.67	No	Yes	0	1	4
86	R:R:H301	R:R:Y109	20.69	Yes	Yes	4	4	4
87	R:R:M111	R:R:T113	3.01	No	No	0	4	4
88	R:R:T113	R:R:V196	6.35	No	No	0	4	4
89	R:R:P115	R:R:W114	2.7	No	Yes	6	3	8
90	R:R:F116	R:R:W114	12.03	Yes	Yes	6	7	8
91	R:R:G117	R:R:W114	2.81	No	Yes	0	7	8
92	R:R:C121	R:R:W114	9.14	No	Yes	0	9	8
93	R:R:V124	R:R:W114	4.9	No	Yes	0	5	8
94	R:R:F116	R:R:P115	20.23	Yes	No	6	7	3
95	R:R:F116	R:R:L120	6.09	Yes	No	0	7	6
96	R:R:E118	R:R:V188	8.56	No	No	0	4	4
97	R:R:E118	R:R:T189	8.47	No	No	0	4	4
98	R:R:C121	R:R:T189	3.38	No	No	0	9	4
99	R:R:C121	R:R:C198	7.28	No	No	0	9	9
100	R:R:I183	R:R:S126	3.1	No	No	0	4	6
101	R:R:M184	R:R:S126	6.13	No	No	0	4	6
102	R:R:I127	R:R:N131	4.25	No	No	0	5	8
103	R:R:D128	R:R:Y308	3.45	No	Yes	1	5	7
104	R:R:I183	R:R:Y129	15.71	No	No	0	4	5
105	R:R:T134	R:R:Y130	7.49	No	No	2	8	5
106	R:R:W173	R:R:Y130	9.65	Yes	No	2	9	5
107	R:R:A176	R:R:Y130	2.67	No	No	0	8	5
108	R:R:M132	R:R:W274	6.98	No	Yes	1	8	8
109	R:R:F133	R:R:F137	8.57	Yes	No	0	7	6
110	R:R:F133	R:R:V179	3.93	Yes	No	0	7	4
111	R:R:F133	R:R:V217	2.62	Yes	No	0	7	5
112	R:R:A221	R:R:F133	2.77	No	Yes	0	6	7
113	R:R:T134	R:R:W173	14.55	No	Yes	2	8	9
114	R:R:I136	R:R:P225	3.39	No	No	0	7	8
115	R:R:F270	R:R:I136	6.28	Yes	No	1	9	7
116	R:R:I136	R:R:W274	4.7	No	Yes	1	7	8
117	R:R:F137	R:R:I172	6.28	No	No	0	6	6
118	R:R:F270	R:R:L139	2.44	Yes	No	0	9	8
119	R:R:P225	R:R:T140	3.5	No	No	0	8	7
120	R:R:I228	R:R:T140	4.56	No	No	0	7	7
121	R:R:I168	R:R:M141	5.83	No	No	2	5	7
122	R:R:I172	R:R:M141	2.92	No	No	0	6	7
123	R:R:M142	R:R:R146	3.72	No	No	0	9	9
124	R:R:S143	R:R:V144	3.23	Yes	No	3	9	7
125	R:R:I229	R:R:S143	6.19	No	Yes	0	8	9
126	R:R:C232	R:R:S143	5.16	No	Yes	3	8	9
127	R:R:S143	R:R:Y233	5.09	Yes	Yes	0	9	8
128	R:R:C232	R:R:V144	3.42	No	No	3	8	7
129	R:R:D145	R:R:R160	16.68	No	Yes	0	8	6
130	R:R:R146	R:R:Y233	9.26	No	Yes	0	9	8
131	R:R:I148	R:R:Y147	3.63	Yes	Yes	3	5	8
132	R:R:C151	R:R:Y147	6.72	No	Yes	0	7	8
133	R:R:H152	R:R:Y147	6.53	No	Yes	3	6	8
134	R:R:C232	R:R:Y147	6.72	No	Yes	3	8	8
135	R:R:L235	R:R:Y147	7.03	No	Yes	0	4	8
136	R:R:H152	R:R:I148	3.98	No	Yes	3	6	5
137	R:R:F159	R:R:I148	2.51	No	Yes	0	3	5
138	R:R:I148	R:R:R160	2.51	Yes	Yes	0	5	6
139	R:R:A149	R:R:R160	6.91	No	Yes	0	8	6
140	R:R:M236	R:R:V150	6.09	No	No	0	8	8
141	R:R:R239	R:R:V150	2.62	Yes	No	0	5	8
142	R:R:L240	R:R:V150	2.98	No	No	0	8	8
143	R:R:C151	R:R:R239	2.79	No	Yes	0	7	5
144	R:R:A156	R:R:R160	2.77	No	Yes	0	5	6
145	R:R:F159	R:R:K164	2.48	No	No	0	3	4
146	R:R:P162	R:R:T161	3.5	No	No	0	3	7
147	R:R:K164	R:R:T161	4.5	No	No	0	4	7
148	R:R:N169	R:R:W173	4.52	No	Yes	2	7	9
149	R:R:P182	R:R:V181	3.53	No	No	0	7	4
150	R:R:I183	R:R:L200	2.85	No	Yes	0	4	4
151	R:R:L200	R:R:M186	5.65	Yes	Yes	7	4	4
152	R:R:F202	R:R:M186	3.73	Yes	Yes	7	6	4
153	R:R:M186	R:R:P203	3.35	Yes	No	0	4	6
154	R:R:Q201	R:R:V188	4.3	No	No	0	4	4
155	R:R:P191	R:R:V196	5.3	No	No	0	1	4
156	R:R:M199	R:R:V197	3.04	No	No	0	4	4
157	R:R:F202	R:R:L200	7.31	Yes	Yes	7	6	4
158	R:R:F202	R:R:S206	2.64	Yes	No	0	6	3
159	R:R:F202	R:R:W209	3.01	Yes	No	0	6	4
160	R:R:D210	R:R:F202	9.55	No	Yes	0	4	6
161	R:R:F202	R:R:T213	9.08	Yes	No	0	6	6
162	R:R:P205	R:R:S204	3.56	Yes	No	0	2	4
163	R:R:P205	R:R:W207	4.05	Yes	No	8	2	3
164	R:R:P205	R:R:Y208	5.56	Yes	No	8	2	3
165	R:R:P205	R:R:W209	2.7	Yes	No	0	2	4
166	R:R:W207	R:R:Y208	4.82	No	No	8	3	3
167	R:R:V212	R:R:Y208	7.57	No	No	0	4	3
168	R:R:D210	R:R:K214	13.83	No	Yes	0	4	5
169	R:R:K214	R:R:V281	4.55	Yes	No	1	5	6
170	R:R:K214	R:R:T285	4.5	Yes	No	0	5	4
171	R:R:F218	R:R:L219	2.44	Yes	No	0	5	4
172	R:R:F218	R:R:F222	5.36	Yes	No	1	5	8
173	R:R:F218	R:R:V223	3.93	Yes	No	0	5	4
174	R:R:F218	R:R:H278	4.53	Yes	Yes	1	5	7
175	R:R:A275	R:R:F222	4.16	No	No	0	6	8
176	R:R:F222	R:R:H278	3.39	No	Yes	1	8	7
177	R:R:P225	R:R:V224	3.53	No	No	0	8	5
178	R:R:F270	R:R:I226	2.51	Yes	No	0	9	6
179	R:R:I226	R:R:V271	3.07	No	No	0	6	6
180	R:R:L235	R:R:V231	2.98	No	No	0	4	4
181	R:R:V263	R:R:Y233	16.4	No	Yes	0	7	8
182	R:R:V267	R:R:Y233	2.52	No	Yes	0	7	8
183	R:R:L237	R:R:R241	3.64	Yes	No	0	5	4
184	R:R:L237	R:R:T260	5.9	Yes	Yes	0	5	7
185	R:R:R239	R:R:V243	3.92	Yes	No	0	5	6
186	R:R:L240	R:R:V243	2.98	No	No	0	8	6
187	R:R:I259	R:R:L240	2.85	No	No	0	8	8
188	R:R:L256	R:R:R241	3.64	No	No	0	6	4
189	R:R:L245	R:R:S255	3	No	No	0	3	5
190	R:R:K252	R:R:L246	2.82	No	No	0	2	2
191	R:R:K250	R:R:R254	8.66	No	No	0	2	4
192	R:R:K252	R:R:L256	8.46	No	No	0	2	6
193	R:R:L256	R:R:T260	2.95	No	Yes	0	6	7
194	R:R:R257	R:R:T260	3.88	No	Yes	0	5	7
195	R:R:R258	R:R:R261	6.4	Yes	No	9	7	6
196	R:R:L321	R:R:R258	3.64	Yes	Yes	9	6	7
197	R:R:E323	R:R:R258	12.79	No	Yes	0	4	7
198	R:R:K326	R:R:R258	3.71	No	Yes	0	8	7
199	R:R:L321	R:R:R261	3.64	Yes	No	9	6	6
200	R:R:L321	R:R:M262	9.9	Yes	No	0	6	8
201	R:R:L317	R:R:V265	2.98	No	No	0	8	6
202	R:R:F270	R:R:W274	4.01	Yes	Yes	1	9	8
203	R:R:C273	R:R:N310	7.87	No	Yes	0	8	9
204	R:R:H278	R:R:W274	4.23	Yes	Yes	1	7	8
205	R:R:N310	R:R:W274	6.78	Yes	Yes	0	9	8
206	R:R:C303	R:R:I277	4.91	No	No	0	6	5
207	R:R:I277	R:R:I304	2.94	No	No	0	5	5
208	R:R:F280	R:R:V283	2.62	Yes	No	0	5	4
209	R:R:A299	R:R:F280	2.77	No	Yes	0	5	5
210	R:R:F280	R:R:L300	3.65	Yes	No	0	5	5
211	R:R:R291	R:R:W284	10	No	No	0	1	4
212	R:R:L286	R:R:T285	2.95	No	No	0	4	4
213	R:R:D290	R:R:I289	7	No	No	0	3	1
214	R:R:D290	R:R:D293	10.65	No	Yes	0	3	3
215	R:R:D293	R:R:P294	9.66	Yes	No	0	3	2
216	R:R:D293	R:R:L295	2.71	Yes	No	0	3	2
217	R:R:D293	R:R:V296	2.92	Yes	No	0	3	5
218	R:R:H301	R:R:V297	2.77	Yes	No	4	4	4
219	R:R:N310	R:R:N314	5.45	Yes	No	0	9	9
220	R:R:L313	R:R:L317	4.15	No	No	0	7	8
221	R:R:D322	R:R:Y318	6.9	No	Yes	0	8	9
222	R:R:F325	R:R:Y318	9.28	No	Yes	0	8	9
223	R:R:F320	R:R:K326	2.48	No	No	0	7	8
224	R:R:D322	R:R:N324	2.69	No	No	0	8	7
225	R:R:C328	R:R:N324	3.15	No	No	0	6	7
226	R:R:C328	R:R:R327	4.18	No	No	0	6	5
227	R:R:I289	R:R:W284	2.35	No	No	0	1	4
228	R:R:G66	R:R:P315	2.03	No	No	0	7	9
229	R:R:G180	R:R:P182	2.03	No	No	0	7	7
230	R:R:C303	R:R:P276	1.88	No	No	0	6	9
231	R:R:G248	R:R:S247	1.86	No	No	0	2	3
232	R:R:A165	R:R:A83	1.79	No	No	0	7	5
233	R:R:P294	R:R:S45	1.78	No	No	0	2	6
234	R:R:G66	R:R:L65	1.71	No	No	0	7	4
235	R:R:G66	R:R:L69	1.71	No	No	0	7	6
236	R:R:C216	R:R:V212	1.71	No	No	0	3	4
237	R:R:G234	R:R:L237	1.71	No	Yes	0	3	5
238	R:R:C273	R:R:V272	1.71	No	No	0	8	6
239	R:R:G307	R:R:L306	1.71	No	No	0	7	7
240	R:R:A309	R:R:V59	1.7	No	No	0	5	7
241	R:R:A195	R:R:V197	1.7	No	No	0	2	4
242	R:R:G307	R:R:N310	1.7	No	Yes	0	7	9
243	R:R:A163	R:R:T161	1.68	No	No	0	4	7
244	R:R:L102	R:R:P103	1.64	Yes	No	0	7	8
245	R:R:A51	R:R:I52	1.62	No	No	0	4	5
246	R:R:S177	R:R:V181	1.62	No	No	0	4	4
247	R:R:A187	R:R:K122	1.61	No	No	0	4	7
248	R:R:S100	R:R:T101	1.6	No	Yes	0	5	7
249	R:R:V181	R:R:V185	1.6	No	No	0	4	4
250	R:R:V265	R:R:V266	1.6	No	No	0	6	7
251	R:R:C171	R:R:L167	1.59	No	No	0	3	3
252	R:R:T230	R:R:V267	1.59	No	No	0	4	7
253	R:R:A49	R:R:L110	1.58	No	No	0	4	4
254	R:R:A187	R:R:L200	1.58	No	Yes	0	4	4
255	R:R:A269	R:R:L313	1.58	No	No	0	6	7
256	R:R:I74	R:R:V75	1.54	No	No	0	7	3
257	R:R:I170	R:R:V174	1.54	No	No	0	4	4
258	R:R:H152	R:R:P153	1.53	No	No	0	6	8
259	R:R:M186	R:R:V185	1.52	Yes	No	0	4	4
260	R:R:I215	R:R:T211	1.52	No	No	0	4	2
261	R:R:L46	R:R:S44	1.5	No	No	0	2	4
262	R:R:L125	R:R:V124	1.49	No	No	0	5	5
263	R:R:L237	R:R:V263	1.49	Yes	No	0	5	7
264	R:R:L245	R:R:V243	1.49	No	No	0	3	6
265	R:R:L321	R:R:V265	1.49	Yes	No	0	6	6
266	R:R:L286	R:R:V287	1.49	No	No	0	4	3
267	R:R:I215	R:R:I282	1.47	No	No	0	4	6
268	R:R:L227	R:R:T230	1.47	No	No	0	4	4
269	R:R:L264	R:R:T260	1.47	No	Yes	0	5	7
270	R:R:K79	R:R:K81	1.44	No	No	0	5	6
271	R:R:P191	R:R:R190	1.44	No	No	0	1	3
272	R:R:I282	R:R:L286	1.43	No	No	0	6	4
273	R:R:L110	R:R:M111	1.41	No	No	0	4	4
274	R:R:A319	R:R:F325	1.39	No	No	0	7	8
275	R:R:L302	R:R:L55	1.38	No	No	0	5	5
276	R:R:A195	R:R:R292	1.38	No	No	0	2	1
277	R:R:A49	R:R:Y109	1.33	No	Yes	0	4	4
278	R:R:E251	R:R:L245	1.33	No	No	0	3	3
279	R:R:R239	R:R:S242	1.32	Yes	No	0	5	4
280	R:R:R254	R:R:S255	1.32	No	No	0	4	5
281	R:R:F280	R:R:V296	1.31	Yes	No	0	5	5
282	R:R:V266	R:R:Y233	1.26	No	Yes	0	7	8
283	R:R:F220	R:R:L219	1.22	No	No	0	4	4
284	R:R:L238	R:R:R241	1.21	No	No	0	4	4
285	R:R:R291	R:R:R292	1.07	No	No	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.70538	13	1	0
2	R:R:Y56	5.73333	6	0	7
3	R:R:Y87	4.982	5	2	7
4	R:R:F89	4.7	5	0	6
5	R:R:L91	3.505	4	5	9
6	R:R:D95	4.218	5	5	9
7	R:R:T101	5.748	5	1	7
8	R:R:L102	6.98	4	0	7
9	R:R:Y109	7.86	5	4	4
10	R:R:W114	5.84333	6	6	8
11	R:R:F116	10.3925	4	6	7
12	R:R:F133	4.4725	4	0	7
13	R:R:S143	4.9175	4	3	9
14	R:R:Y147	6.126	5	3	8
15	R:R:I148	3.1575	4	3	5
16	R:R:R160	7.2175	4	0	6
17	R:R:W173	7.48333	6	2	9
18	R:R:M186	3.5625	4	7	4
19	R:R:L200	4.3475	4	7	4
20	R:R:F202	5.88667	6	7	6
21	R:R:P205	3.9675	4	8	2
22	R:R:K214	7.0675	4	1	5
23	R:R:F218	4.065	4	1	5
24	R:R:Y233	6.906	5	0	8
25	R:R:L237	3.185	4	0	5
26	R:R:R239	2.6625	4	0	5
27	R:R:R258	6.635	4	9	7
28	R:R:T260	3.55	4	0	7
29	R:R:F270	3.81	4	1	9
30	R:R:W274	5.59167	6	1	8
31	R:R:H278	3.915	4	1	7
32	R:R:F280	2.5875	4	0	5
33	R:R:D293	6.485	4	0	3
34	R:R:H301	9.2975	4	4	4
35	R:R:Y308	8.1475	4	1	7
36	R:R:N310	5.45	4	0	9
37	R:R:Y318	8.0275	4	0	9
38	R:R:L321	4.6675	4	9	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W284	22.7284	4.98	Yes	No	0	0	4
2	R:R:I289	R:R:W284	15.6952	2.35	No	No	0	1	4
3	R:R:D290	R:R:I289	14.4223	7	No	No	0	3	1
4	R:R:D290	R:R:D293	13.1408	10.65	No	Yes	0	3	3
5	L:L:?1	R:R:I277	32.5476	3.9	Yes	No	0	0	5
6	R:R:I277	R:R:I304	30.0274	2.94	No	No	0	5	5
7	R:R:I304	R:R:Y56	29.256	7.25	No	Yes	0	5	7
8	R:R:I52	R:R:Y56	22.0813	3.63	No	Yes	0	5	7
9	L:L:?1	R:R:Y308	58.9191	6.41	Yes	Yes	1	0	7
10	R:R:L102	R:R:Y308	33.3105	15.24	Yes	Yes	0	7	7
11	R:R:L102	R:R:Y56	29.9503	4.69	Yes	Yes	0	7	7
12	R:R:I52	R:R:Y109	18.121	12.09	No	Yes	0	5	4
13	R:R:H301	R:R:Y56	24.3571	9.8	Yes	Yes	0	4	7
14	R:R:H301	R:R:Y109	18.5153	20.69	Yes	Yes	4	4	4
15	R:R:A305	R:R:Y56	10.732	2.67	No	Yes	0	5	7
16	L:L:?1	R:R:S135	13.4365	4.92	Yes	No	0	0	9
17	R:R:D95	R:R:S135	12.3007	2.94	Yes	No	0	9	9
18	L:L:?1	R:R:S311	13.4451	6.56	Yes	No	0	0	9
19	R:R:D95	R:R:S311	12.3007	7.36	Yes	No	0	9	9
20	R:R:D95	R:R:N67	15.4766	4.04	Yes	No	0	9	9
21	R:R:N67	R:R:P315	10.3506	6.52	No	No	0	9	9
22	L:L:?1	R:R:V217	100	2.44	Yes	No	0	0	5
23	R:R:F133	R:R:V217	99.6571	2.62	Yes	No	0	7	5
24	R:R:F133	R:R:F137	98.4399	8.57	Yes	No	0	7	6
25	R:R:F137	R:R:I172	98.0156	6.28	No	No	0	6	6
26	R:R:I172	R:R:M141	97.5827	2.92	No	No	0	6	7
27	R:R:M141	R:R:Y87	96.2326	8.38	No	Yes	2	7	7
28	R:R:M142	R:R:Y87	50.1286	3.59	No	Yes	0	9	7
29	R:R:I88	R:R:M142	15.3094	2.92	No	No	0	8	9
30	R:R:I88	R:R:Y318	12.6479	10.88	No	Yes	0	8	9
31	R:R:N169	R:R:Y87	35.0377	4.65	No	Yes	2	7	7
32	R:R:N169	R:R:N90	26.3672	17.71	No	No	2	7	9
33	R:R:F89	R:R:N90	25.63	3.62	Yes	No	0	6	9
34	R:R:F89	R:R:I74	17.3796	2.51	Yes	No	0	6	7
35	R:R:D145	R:R:Y87	33.9319	3.45	No	Yes	0	8	7
36	L:L:?1	R:R:W274	19.2654	6.85	Yes	Yes	1	0	8
37	R:R:T101	R:R:Y308	24.4643	7.49	Yes	Yes	1	7	7
38	R:R:F104	R:R:T101	21.5798	3.89	No	Yes	0	6	7
39	R:R:F104	R:R:F116	10.9206	3.22	No	Yes	0	6	7
40	R:R:A49	R:R:Y109	28.6045	1.33	No	Yes	0	4	4
41	R:R:A49	R:R:L110	24.7043	1.58	No	No	0	4	4
42	R:R:L110	R:R:M111	20.6112	1.41	No	No	0	4	4
43	R:R:M111	R:R:T113	16.5052	3.01	No	No	0	4	4
44	R:R:T113	R:R:V196	12.3907	6.35	No	No	0	4	4
45	R:R:C121	R:R:W114	12.8022	9.14	No	Yes	0	9	8
46	L:L:?1	R:R:Y129	16.6724	12.17	Yes	No	0	0	5
47	R:R:I183	R:R:Y129	15.5237	15.71	No	No	0	4	5
48	R:R:M142	R:R:R146	38.7708	3.72	No	No	0	9	9
49	R:R:R146	R:R:Y233	37.9693	9.26	No	Yes	0	9	8
50	R:R:D145	R:R:R160	32.8476	16.68	No	Yes	0	8	6
51	R:R:I148	R:R:R160	29.9417	2.51	Yes	Yes	0	5	6
52	R:R:I148	R:R:Y147	22.3899	3.63	Yes	Yes	3	5	8
53	R:R:C151	R:R:Y147	19.8911	6.72	No	Yes	0	7	8
54	R:R:C151	R:R:R239	18.5882	2.79	No	Yes	0	7	5
55	R:R:R239	R:R:V243	10.8392	3.92	Yes	No	0	5	6
56	R:R:I183	R:R:L200	12.2236	2.85	No	Yes	0	4	4
57	R:R:M186	R:R:V185	12.5964	1.52	Yes	No	0	4	4
58	R:R:V181	R:R:V185	10.0934	1.6	No	No	0	4	4
59	L:L:?1	R:R:K214	29.9203	5.39	Yes	Yes	1	0	5
60	R:R:D210	R:R:K214	22.3213	13.83	No	Yes	0	4	5
61	R:R:D210	R:R:F202	21.1812	9.55	No	Yes	0	4	6
62	R:R:V263	R:R:Y233	18.2668	16.4	No	Yes	0	7	8
63	R:R:L237	R:R:V263	17.1353	1.49	Yes	No	0	5	7
64	R:R:V266	R:R:Y233	15.3652	1.26	No	Yes	0	7	8
65	R:R:V265	R:R:V266	14.2251	1.6	No	No	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A98	4.3	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y129	12.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:M132	5.41	1	Yes	No	0	8	0	1
L:L:?1	R:R:S135	4.92	1	Yes	No	0	9	0	1
L:L:?1	R:R:K214	5.39	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V217	2.44	1	Yes	No	0	5	0	1
L:L:?1	R:R:W274	6.85	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I277	3.9	1	Yes	No	0	5	0	1
L:L:?1	R:R:H278	3.51	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V281	7.33	1	Yes	No	0	6	0	1
L:L:?1	R:R:W284	4.98	1	Yes	No	0	4	0	1
L:L:?1	R:R:Y308	6.41	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S311	6.56	1	Yes	No	0	9	0	1
R:R:D95	R:R:S135	2.94	5	Yes	No	9	9	2	1
R:R:D95	R:R:S311	7.36	5	Yes	No	9	9	2	1
R:R:A98	R:R:N131	4.69	0	No	No	6	8	1	2
R:R:D128	R:R:T101	8.67	1	No	Yes	5	7	2	2
R:R:T101	R:R:Y308	7.49	1	Yes	Yes	7	7	2	1
R:R:L102	R:R:Y308	15.24	0	Yes	Yes	7	7	2	1
R:R:D128	R:R:Y308	3.45	1	No	Yes	5	7	2	1
R:R:I183	R:R:Y129	15.71	0	No	No	4	5	2	1
R:R:M132	R:R:W274	6.98	1	No	Yes	8	8	1	1
R:R:F133	R:R:V217	2.62	0	Yes	No	7	5	2	1
R:R:F270	R:R:I136	6.28	1	Yes	No	9	7	2	2
R:R:I136	R:R:W274	4.7	1	No	Yes	7	8	2	1
R:R:D210	R:R:K214	13.83	0	No	Yes	4	5	2	1
R:R:K214	R:R:V281	4.55	1	Yes	No	5	6	1	1
R:R:K214	R:R:T285	4.5	1	Yes	No	5	4	1	2
R:R:F218	R:R:F222	5.36	1	Yes	No	5	8	2	2
R:R:F218	R:R:H278	4.53	1	Yes	Yes	5	7	2	1
R:R:F222	R:R:H278	3.39	1	No	Yes	8	7	2	1
R:R:F270	R:R:W274	4.01	1	Yes	Yes	9	8	2	1
R:R:H278	R:R:W274	4.23	1	Yes	Yes	7	8	1	1
R:R:N310	R:R:W274	6.78	0	Yes	Yes	9	8	2	1
R:R:C303	R:R:I277	4.91	0	No	No	6	5	2	1
R:R:I277	R:R:I304	2.94	0	No	No	5	5	1	2
R:R:R291	R:R:W284	10	0	No	No	1	4	2	1
R:R:I289	R:R:W284	2.35	0	No	No	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9CGJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	261
Number of Links	285
Number of Hubs	38
Number of Links mediated by Hubs	155
Number of Communities	9
Number of Nodes involved in Communities	47
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	46975
Length Of Smallest Path	3
Average Path Length	13.4447
Length of Longest Path	30
Minimum Path Strength	1.225
Average Path Strength	5.58499
Maximum Path Strength	13.94
Minimum Path Correlation	0.7
Average Path Correlation	0.922273
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	45.3491
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.9025
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • G protein-coupled enkephalin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • neuropeptide binding • peptide binding • receptor serine/threonine kinase binding • neuropeptide signaling pathway • adult locomotory behavior • behavior • multicellular organismal process • adult behavior • locomotory behavior • regulation of calcium ion transport • regulation of monoatomic ion transport • metal ion transport • calcium ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • immune response • regulation of mitochondrial membrane potential • regulation of membrane potential • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • G protein-coupled opioid receptor signaling pathway • eating behavior • feeding behavior • negative regulation of cellular component organization • protein-containing complex organization • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • response to ethanol • cellular response to growth factor stimulus • response to growth factor • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to toxic substance • response to toxic substance • negative regulation of metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of macromolecule metabolic process • response to nicotine • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • postsynapse • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • presynapse • presynaptic membrane • cell leading edge • leading edge membrane • somatodendritic compartment • neuron projection membrane • dendrite membrane • dendrite • dendritic tree • cell projection membrane • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus • neuron spine • dendritic spine • spine apparatus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41143
Sequence	>9CGJ_nogp_Chain_R S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E T W P F G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P A K A K L I N I C I W V L A S G V G V P I M V M A V T R P G A V V C M L Q F P S P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V R L L S G S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D I D R R D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F K R C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4N6H	A	Peptide	Opioid	δ	Homo sapiens	Naltrindole	Na	-	1.8	2013-12-25	doi.org/10.1038/nature12944
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	8F7S	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-	Gi1/β1/γ2	3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7S (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	Deltorphin	-		3	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4EJ4	A	Peptide	Opioid	δ	Mus musculus	Naltrindole	-	-	3.4	2012-05-16	doi.org/10.1038/nature11111
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	6PT2	A	Peptide	Opioid	δ	Homo sapiens	KGCHM07	-	-	2.8	2019-12-11	doi.org/10.1126/sciadv.aax9115
	6PT3	A	Peptide	Opioid	δ	Homo sapiens	DPI-287	-	-	3.3	2019-12-11	doi.org/10.1126/sciadv.aax9115
	8Y45	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-	Gi2/β1/γ2	3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	8Y45 (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	ADL5859	-		3.45	2024-11-27	doi.org/10.1038/s41467-024-52601-1
	9CGJ	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-	Gi1/β1/γ2	2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGJ (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C6-Quino	-		2.8	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-	Gi1/β1/γ2	2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5
	9CGK (No Gprot)	A	Peptide	Opioid	δ	Homo sapiens	C5-Quino	-		2.62	2025-04-02	doi.org/10.1038/s41467-025-57734-5

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