Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R15 3.90754175
2A:A:V34 5.856565
3A:A:K35 4.438519
4A:A:H188 9.1375413
5A:A:F191 9.2525465
6A:A:F196 8.28833667
7A:A:K197 10.9075416
8A:A:M198 5.3775407
9A:A:F199 10.325415
10A:A:Q204 7.42419
11A:A:K210 7.43429719
12A:A:W211 6.235619
13A:A:H213 7.7875418
14A:A:C214 5.592517
15A:A:F215 8.59419
16A:A:F223 6.496549
17A:A:Y230 9.0785208
18A:A:M247 5.1475406
19A:A:F250 6.23167649
20A:A:C254 4.4025445
21A:A:N255 5.7875408
22A:A:W258 8.9405
23A:A:F259 7.8025409
24A:A:I265 3.6725408
25A:A:L266 6.295449
26A:A:F267 4.36754229
27A:A:N269 10.51754139
28A:A:F274 8.385409
29A:A:K277 8.7545209
30A:A:L283 6.0525407
31A:A:Y287 5.947147217
32A:A:Y290 6.6507
33A:A:Y296 7.595404
34A:A:F307 6.98448
35A:A:N311 6.455448
36A:A:Y320 7.47333687
37A:A:D328 4.56254189
38A:A:Q333 7.125465
39A:A:F336 7.04167668
40A:A:I343 4.1407
41A:A:K345 5.95685
42A:A:L353 5.835107
43A:A:F354 6.9625405
44B:B:V40 5493
45B:B:L51 9.9025429
46B:B:H54 7.56167629
47B:B:Y59 9.588518
48B:B:W63 7.91527
49B:B:L69 5.6775455
50B:B:L70 6.72425
51B:B:V71 4.42408
52B:B:L79 4.13754147
53B:B:W82 9.04857729
54B:B:N88 5.7925457
55B:B:K89 7.2125409
56B:B:L95 4.0885148
57B:B:W99 8.90667619
58B:B:Y105 4.144506
59B:B:Y111 5.1245114
60B:B:L117 4.645619
61B:B:I123 4.734116
62B:B:Y124 5.621676146
63B:B:N125 5.62254114
64B:B:S136 5.32754114
65B:B:H142 9.62519
66B:B:Y145 6.40778918
67B:B:C148 4.3375406
68B:B:R150 8.0075406
69B:B:F151 5.286119
70B:B:Q156 5.2775405
71B:B:T159 5.4425419
72B:B:G162 4.14419
73B:B:D163 7.796519
74B:B:W169 12.018518
75B:B:Q176 7.8825414
76B:B:F180 8.476537
77B:B:H183 8.266539
78B:B:D186 7.086519
79B:B:V187 5.03439
80B:B:M188 6.5725418
81B:B:F199 8.1025439
82B:B:V200 8.61416
83B:B:S201 3.99439
84B:B:C204 5.8575417
85B:B:K209 9.666536
86B:B:W211 8.04714738
87B:B:D212 8.914259
88B:B:C218 5.69435
89B:B:Q220 8.625417
90B:B:T221 7.095437
91B:B:F222 9.115418
92B:B:H225 11.098519
93B:B:D228 8.9825419
94B:B:F234 7.1625415
95B:B:F235 8.6256126
96B:B:P236 6.75254127
97B:B:F241 7.56167616
98B:B:D247 9.5025419
99B:B:R251 9.76714718
100B:B:F253 8.088516
101B:B:Q259 6.4465246
102B:B:M262 5.995404
103B:B:Y264 7.6875405
104B:B:I269 5.6725414
105B:B:R283 6.88599
106B:B:Y289 6.30667617
107B:B:D290 7.68416
108B:B:V296 3.58405
109B:B:W297 7.93418
110B:B:L300 3.97167606
111B:B:R304 15.51415
112B:B:H311 6.36679
113B:B:V315 4.7625477
114B:B:T329 5.2475478
115B:B:W332 11.7386719
116B:B:D333 6.38479
117B:B:K337 7.725476
118B:B:W339 9.67579
119G:G:Y40 12.44126
120G:G:D48 6.04699
121G:G:L50 5.39499
122G:G:L51 3.342596
123G:G:F61 6.02658
124R:R:Y38 3.934507
125R:R:L56 5.56254107
126R:R:D67 5.885408
127R:R:Y69 5.63607
128R:R:L84 6.654267
129R:R:C102 3.6725409
130R:R:F114 4.95607
131R:R:F119 10.5825158
132R:R:T121 3.525407
133R:R:R127 6.24754239
134R:R:Y128 5.901676168
135R:R:Y179 8.714285
136R:R:W187 6.0954284
137R:R:Y211 7.43409
138R:R:R213 6.84754164
139R:R:N223 4.6075483
140R:R:F240 7.196279
141R:R:F241 6.5825406
142R:R:W244 10.45279
143R:R:Y247 6.54507
144R:R:F262 6.9185291
145R:R:D266 5.0075402
146R:R:M267 8.44754291
147R:R:V277 2.195405
148R:R:Y303 6.4475404
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Q75 B:B:W99 41.32186.57NoYes199
2B:B:Q75 B:B:Y59 40.74659.02NoYes198
3B:B:W332 B:B:Y59 48.640612.54YesYes198
4B:B:S316 B:B:W332 21.01354.94NoYes099
5B:B:C317 B:B:S316 20.71973.44NoNo079
6B:B:C317 B:B:M61 20.45534.86NoNo076
7A:A:F215 B:B:W99 42.396414.03YesYes199
8A:A:F215 A:A:L37 98.141110.96YesNo099
9A:A:L37 A:A:L39 99.89024.15NoNo099
10A:A:F223 A:A:L39 1003.65YesNo099
11A:A:F223 A:A:F250 50.857516.08YesYes499
12A:A:F250 A:A:F307 51.33366.43YesYes498
13A:A:F307 A:A:V225 93.8629.18YesNo087
14A:A:L268 A:A:V225 93.65624.47NoNo087
15A:A:L227 A:A:L268 93.33379.69NoNo1978
16A:A:F274 A:A:L227 93.469213.4YesNo097
17A:A:F274 A:A:Y296 99.36414.13YesYes094
18A:A:K271 A:A:Y296 99.05367.17NoYes054
19A:A:C325 A:A:K271 98.99083.23NoNo075
20A:A:C325 A:A:K330 98.92774.85NoNo074
21B:B:H62 B:B:Y105 12.51553.27NoYes066
22B:B:H62 B:B:R150 12.753821.44NoYes066
23B:B:C148 B:B:R150 20.5254.18YesYes066
24B:B:C148 B:B:T102 34.31513.38YesNo068
25B:B:C149 B:B:T102 34.55386.76NoNo088
26B:B:C149 B:B:T159 35.03853.38NoYes089
27B:B:H142 B:B:T159 35.1635.48YesYes199
28B:B:H142 B:B:S161 37.836716.74YesNo199
29B:B:G162 B:B:S161 39.3123.71YesNo199
30B:B:G162 B:B:Y145 39.49325.79YesYes198
31A:A:W211 B:B:Y145 50.3415.79YesYes198
32A:A:F215 A:A:W211 53.32464.01YesYes199
33A:A:F223 A:A:L266 49.86813.65YesYes499
34A:A:F307 A:A:L266 49.96836.09YesYes489
35A:A:K330 A:A:Q333 93.30295.42NoYes045
36A:A:F191 A:A:Q333 47.17855.86YesYes655
37A:A:F191 A:A:F336 46.21775.36YesYes658
38A:A:F196 A:A:F336 90.46155.36YesYes678
39A:A:K192 A:A:Q333 45.98566.78NoYes645
40A:A:F336 A:A:K192 45.878814.89YesNo684
41A:A:F196 A:A:V339 89.4957.87YesNo678
42A:A:K210 B:B:Y145 29.86453.58YesYes198
43A:A:K210 B:B:D228 28.08299.68YesYes199
44A:A:I343 A:A:V339 90.60243.07YesNo078
45A:A:I343 A:A:N347 89.79744.25YesNo078
46A:A:N347 R:R:A130 89.52856.25NoNo088
47R:R:A130 R:R:R127 89.25954.15NoYes089
48R:R:R127 R:R:T66 82.42185.17YesNo2398
49A:A:C351 R:R:T66 82.17885.07NoNo048
50A:A:C351 A:A:F354 81.90336.98NoYes045
51A:A:G352 R:R:K299 80.52165.23NoNo086
52A:A:F354 R:R:K299 81.0756.2YesNo056
53A:A:G352 R:R:D67 80.24465.03NoYes088
54R:R:D67 R:R:L56 79.4125.43YesYes087
55A:A:L353 R:R:L56 77.339711.07YesYes1077
56A:A:L353 R:R:Y293 73.49414.69YesNo1079
57B:B:C148 B:B:L190 11.63246.35YesNo065
58B:B:F199 B:B:L190 11.35794.87YesNo095
59B:B:D228 B:B:S227 27.49067.36YesNo196
60B:B:S227 B:B:S245 27.20983.26NoNo169
61B:B:H225 B:B:S245 25.6569.76YesNo199
62B:B:H225 B:B:R251 14.423718.05YesYes198
63B:B:R314 B:B:W332 38.021223.99NoYes189
64B:B:D290 B:B:R314 28.328716.68YesNo168
65B:B:C271 B:B:D290 28.12624.67NoYes156
66B:B:C271 B:B:Y289 26.87245.38NoYes157
67B:B:W297 B:B:Y289 23.12385.79YesYes187
68B:B:W297 B:B:Y264 22.56777.72YesYes085
69B:B:M262 B:B:Y264 20.746111.97YesYes045
70B:B:L30 B:B:M262 18.87395.65NoYes054
71B:B:L30 B:B:L300 16.9934.15NoYes056
72B:B:L300 B:B:R283 11.29374.86YesYes069
73B:B:H225 B:B:T243 10.03389.58YesNo098
74R:R:V236 R:R:Y293 73.23966.31NoNo079
75R:R:I292 R:R:V236 72.95624.61NoNo087
76R:R:I292 R:R:V239 72.38884.61NoNo087
77R:R:F243 R:R:V239 72.10485.24NoNo087
78R:R:F243 R:R:H285 71.53597.92NoNo089
79R:R:H285 R:R:W244 54.37627.41NoYes2799
80R:R:W244 R:R:Y247 38.72536.75YesYes097
81R:R:E279 R:R:Y247 14.95733.37NoYes057
82R:R:F240 R:R:H285 16.874810.18YesNo2799
83R:R:F113 R:R:W244 16.494219.04NoYes089
84R:R:F113 R:R:F114 16.17644.29NoYes087
85R:R:S76 R:R:W154 14.5954.94NoNo089
86R:R:F119 R:R:W154 11.677513.03YesNo1589
87R:R:F110 R:R:Y247 13.27614.13NoYes057
88R:R:F109 R:R:F80 12.44193.22NoNo077
89R:R:F80 R:R:G112 11.08284.52NoNo078
90R:R:G112 R:R:S76 10.43771.86NoNo088
91R:R:F240 R:R:F241 11.06714.29YesYes096
92B:B:L70 B:B:M61 10.49745.65YesNo256
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7XBW
Class A
SubFamily Protein
Type Chemokine
SubType CX3CR1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.8
Date 2022-07-13
D.O.I. 10.1126/sciadv.abn8048
Net Summary
Imin 3.15
Number of Linked Nodes 849
Number of Links 999
Number of Hubs 148
Number of Links mediated by Hubs 557
Number of Communities 29
Number of Nodes involved in Communities 209
Number of Links involved in Communities 293
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 1225738
Length Of Smallest Path 3
Average Path Length 39.4927
Length of Longest Path 76
Minimum Path Strength 1.355
Average Path Strength 6.66791
Maximum Path Strength 24.18
Minimum Path Correlation 0.72
Average Path Correlation 0.979918
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 39.1194
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.7667
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7XBW_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMKITGIV ETHFTFKDL HFKMFDVTA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHAS MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XBW_Chain_B
EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA 
KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM 
TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR ELAGHTGYL 
SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG HTGDVMSLS 
LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES DINAICFFP 
NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG ITSVSFSKS 
GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC LGVTDDGMA 
VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XBW_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49238
Sequence
>7XBW_Chain_R
IGDIVVFGT VFLSIFYSV IFAIGLVGN LLVVFALTN SKKPKSVTD 
IYLLNLALS DLLFVATLP FWTHYLINE KGLHNAMCK FTTAFFFIG 
FFGSIFFLT VISIDRYLA IVLAANSMN NRTVQHGVT ISLGVWAAA 
ILVAAPQFM FTKQKENEC LGDYPEVLQ EIWPVLRNV ETNFLGFLL 
PLLIMSYCY FRIIQTLFS SKNHKKAKA IKLILLVVI VFFLFWTPY 
NVVIFLETL KLYDFFPSC DMRKDLRLA LSVTETVAF SHCCLNPLI 
YAFAGEKFR RYLYHLYGK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XBWAProteinChemokineCX3CR1Homo sapiens--Gi1/&β;1/&γ;22.82022-07-1310.1126/sciadv.abn8048
7XBXAProteinChemokineCX3CR1Homo sapiensCX3CL1-Gi1/&β;1/&γ;23.42022-07-1310.1126/sciadv.abn8048




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XBW.zip



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