Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.856565
2A:A:K35 4.168519
3A:A:K46 8.275479
4A:A:H188 9.1375413
5A:A:F191 9.2525465
6A:A:F196 8.28833667
7A:A:K197 9.5575416
8A:A:M198 5.3775407
9A:A:F199 10.325415
10A:A:Q204 7.42419
11A:A:R208 4.18419
12A:A:K210 7.54833619
13A:A:W211 5.77286719
14A:A:H213 7.7875418
15A:A:C214 5.592517
16A:A:F215 8.59419
17A:A:F223 6.496519
18A:A:V225 5.7875407
19A:A:Y230 7.646508
20A:A:M247 5.1475406
21A:A:F250 6.23167619
22A:A:C254 4.4025415
23A:A:N255 5.7875408
24A:A:W258 8.9405
25A:A:F259 7.8025409
26A:A:I265 3.6725408
27A:A:L266 6.295419
28A:A:F267 4.36754229
29A:A:N269 9.4675479
30A:A:F274 8.385409
31A:A:K277 5.9854159
32A:A:L283 6.0525407
33A:A:Y287 5.947147217
34A:A:Y290 5.926507
35A:A:Y296 7.595404
36A:A:F307 6.98418
37A:A:N311 6.455418
38A:A:Y320 5.415687
39A:A:D328 6.3325479
40A:A:F336 7.04167668
41A:A:I343 4.1407
42A:A:K345 6.06585
43A:A:L353 5.83597
44A:A:F354 6.5025255
45B:B:L30 5.7425455
46B:B:I37 3.4325402
47B:B:V40 5453
48B:B:L51 9.9025429
49B:B:H54 7.56167629
50B:B:Y59 8.62667618
51B:B:W63 7.91527
52B:B:L69 5.3725425
53B:B:L70 6.72425
54B:B:V71 4.424108
55B:B:L79 3.9065107
56B:B:W82 9.04857729
57B:B:N88 5.7925427
58B:B:K89 7.2125409
59B:B:L95 4.0885108
60B:B:W99 8.90667619
61B:B:Y105 4.144506
62B:B:Y111 5.1245124
63B:B:V112 5.134108
64B:B:L117 4.645619
65B:B:I123 4.734126
66B:B:Y124 5.621676106
67B:B:N125 5.62254124
68B:B:S136 5.32754124
69B:B:H142 9.062519
70B:B:Y145 6.40778918
71B:B:C148 4.3375436
72B:B:R150 8.0075406
73B:B:F151 5.286129
74B:B:Q156 5.2775405
75B:B:T159 4.962519
76B:B:S160 4.045436
77B:B:G162 4.14419
78B:B:D163 7.796519
79B:B:L168 4.25406
80B:B:W169 12.018518
81B:B:Q176 6.818514
82B:B:F180 8.476537
83B:B:H183 8.266539
84B:B:D186 7.086519
85B:B:V187 5.03439
86B:B:M188 6.5725418
87B:B:L190 4.3435
88B:B:F199 8.1025439
89B:B:V200 8.61416
90B:B:S201 3.99439
91B:B:C204 4.355417
92B:B:D205 6.1025409
93B:B:K209 9.666536
94B:B:W211 8.04714738
95B:B:D212 8.914169
96B:B:R219 5.414165
97B:B:T221 6.39437
98B:B:F222 9.115418
99B:B:H225 12.494519
100B:B:D228 7.808519
101B:B:I229 5.8975417
102B:B:I232 5.095418
103B:B:F234 7.1625415
104B:B:F235 8.6256136
105B:B:P236 6.75254137
106B:B:F241 7.56167616
107B:B:T243 6.185418
108B:B:D247 6.304519
109B:B:R251 8.1618
110B:B:F253 10.186516
111B:B:E260 8.5875416
112B:B:M262 7.165404
113B:B:Y264 7.09405
114B:B:I269 5.6725414
115B:B:F278 8.324137
116B:B:R283 6.88559
117B:B:Y289 6.30667617
118B:B:D290 7.68416
119B:B:V296 3.58405
120B:B:W297 6.944518
121B:B:L300 3.73667656
122B:B:R304 13.008515
123B:B:H311 7.05833649
124B:B:V315 4.7625447
125B:B:L318 3.405406
126B:B:M325 6.385425
127B:B:T329 4.788548
128B:B:W332 12.0914719
129B:B:D333 7.3775449
130B:B:L336 4.13427
131B:B:K337 7.725446
132B:B:W339 9.67549
133G:G:Y40 12.44136
134G:G:D48 6.04659
135G:G:L50 5.39459
136G:G:L51 3.342556
137G:G:P60 6.3429
138G:G:F61 5.87143728
139R:R:Y38 3.934507
140R:R:L56 5.5625497
141R:R:D67 5.97408
142R:R:Y69 5.63607
143R:R:L84 6.654277
144R:R:F86 20.28754147
145R:R:Y90 12.074145
146R:R:C102 3.6725409
147R:R:F109 6.3725407
148R:R:F114 4.95607
149R:R:F119 10.5825178
150R:R:T121 3.4285117
151R:R:R127 6.24754249
152R:R:Y128 5.901676188
153R:R:I149 3.895405
154R:R:Y179 7.875285
155R:R:W187 6.0954284
156R:R:F200 8.0725409
157R:R:Y211 7.43409
158R:R:R213 6.84754184
159R:R:N223 4.6075483
160R:R:F240 7.196119
161R:R:F241 6.5825406
162R:R:W244 8.288577119
163R:R:Y247 6.54507
164R:R:F262 6.1654291
165R:R:M267 8.84291
166R:R:Y293 5.28499
167R:R:F300 3.03498
168R:R:Y303 6.4475404
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F109 R:R:W244 23.41293.01YesYes079
2R:R:H285 R:R:W244 59.13817.41NoYes1199
3R:R:F243 R:R:H285 73.25827.92NoNo089
4R:R:F243 R:R:V239 73.80455.24NoNo087
5R:R:I292 R:R:V239 74.07754.61NoNo087
6R:R:I292 R:R:V236 74.62314.61NoNo087
7R:R:V236 R:R:Y293 74.89586.31NoYes079
8A:A:L353 R:R:Y293 74.99734.69YesYes979
9A:A:L353 R:R:L56 78.347911.07YesYes977
10R:R:D67 R:R:L56 80.59365.43YesYes087
11A:A:C351 R:R:D67 81.36933.11NoYes048
12A:A:C351 R:R:T66 83.00225.07NoNo048
13R:R:R127 R:R:T66 83.25385.17YesNo2498
14R:R:A130 R:R:R127 89.95454.15NoYes089
15A:A:N347 R:R:A130 90.22036.25NoNo088
16A:A:I343 A:A:N347 90.4864.25YesNo078
17A:A:I343 A:A:V339 91.28233.07YesNo078
18A:A:V339 A:A:V34 45.45724.81NoYes685
19A:A:L36 A:A:V34 45.82274.47NoYes675
20A:A:I222 A:A:L36 94.9894.28NoNo077
21A:A:I222 A:A:I265 96.39434.42NoYes078
22A:A:F267 A:A:I265 98.55793.77YesYes098
23A:A:F267 A:A:H322 98.70946.79YesNo2299
24A:A:C325 A:A:H322 98.94512.95NoNo079
25A:A:C325 A:A:K271 99.42643.23NoNo075
26A:A:K271 A:A:Y296 99.52237.17NoYes054
27A:A:F274 A:A:Y296 1004.13YesYes094
28A:A:F274 A:A:L227 97.3513.4YesNo097
29A:A:L227 A:A:L268 97.34689.69NoNo1978
30A:A:L268 A:A:V225 97.70944.47NoYes087
31A:A:F307 A:A:V225 98.29449.18YesYes087
32A:A:F250 A:A:F307 52.63626.43YesYes198
33A:A:F223 A:A:F250 52.971416.08YesYes199
34A:A:F223 A:A:L249 81.20256.09YesNo199
35A:A:L249 A:A:R208 81.06686.07NoYes199
36A:A:R208 A:A:W211 81.06453YesYes199
37A:A:W211 B:B:Y145 39.07095.79YesYes198
38B:B:G162 B:B:Y145 30.25695.79YesYes198
39B:B:G162 B:B:S161 31.98893.71YesNo199
40B:B:H142 B:B:S161 31.205513.95YesNo199
41B:B:H142 B:B:T159 29.75755.48YesYes199
42B:B:C149 B:B:T159 18.7293.38NoYes089
43B:B:C149 B:B:T102 18.50396.76NoNo088
44B:B:C148 B:B:T102 18.38783.38YesNo068
45B:B:H62 B:B:R150 14.600121.44NoYes066
46B:B:H62 B:B:Y105 14.37133.27NoYes066
47B:B:V71 B:B:Y105 10.64593.79YesYes086
48A:A:F196 A:A:V339 46.09027.87YesNo678
49A:A:F196 A:A:L36 49.06543.65YesNo677
50A:A:F307 A:A:L266 52.03076.09YesYes189
51A:A:F223 A:A:L266 52.10953.65YesYes199
52B:B:I157 B:B:T159 11.1433.04NoYes079
53B:B:F151 B:B:I157 11.020210.05YesNo097
54A:A:F215 A:A:L37 22.988610.96YesNo099
55A:A:L37 A:A:L39 23.67584.15NoNo099
56A:A:K210 B:B:Y145 18.22483.58YesYes198
57A:A:K210 B:B:D228 17.26249.68YesYes199
58A:A:C214 B:B:L117 44.4543.17YesYes179
59A:A:H213 B:B:W332 23.40727.41YesYes189
60B:B:N313 B:B:W332 29.50835.65NoYes079
61B:B:D312 B:B:N313 28.80295.39NoNo057
62B:B:D312 B:B:D333 27.75527.98NoYes059
63B:B:D333 B:B:H311 25.3527.56YesYes499
64B:B:G330 B:B:H311 22.13483.18NoYes059
65B:B:G330 B:B:L336 21.81563.42NoYes057
66B:B:L336 B:B:W82 10.07264.56YesYes279
67B:B:W332 B:B:Y59 43.909612.54YesYes198
68B:B:Q75 B:B:Y59 20.89159.02NoYes198
69B:B:Q75 B:B:W99 21.00696.57NoYes199
70B:B:L30 B:B:M262 11.807512.72YesYes054
71B:B:D228 B:B:S227 18.76957.36YesNo196
72B:B:D247 B:B:S227 18.63432.94YesNo196
73B:B:D247 B:B:H225 12.62698.82YesYes199
74B:B:M262 B:B:Y264 13.48349.58YesYes045
75B:B:W297 B:B:Y264 15.98297.72YesYes085
76B:B:W297 B:B:Y289 17.59695.79YesYes187
77B:B:S275 B:B:T274 13.41353.2NoNo088
78B:B:C271 B:B:D290 23.38244.67NoYes156
79B:B:L318 B:B:S275 11.56314.5YesNo068
80B:B:R314 B:B:T274 13.45913.88NoNo188
81B:B:R314 B:B:W332 37.622223.99NoYes189
82R:R:W244 R:R:Y247 23.20456.75YesYes097
83R:R:E279 R:R:F283 17.1883.5NoNo056
84R:R:F283 R:R:Y38 14.23173.09NoYes067
85R:R:F240 R:R:H285 13.846610.18YesNo1199
86R:R:F113 R:R:W244 10.115219.04NoYes089
87R:R:F110 R:R:Q164 10.039314.05NoNo054
88A:A:F223 A:A:L39 23.82233.65YesNo099
89A:A:F215 B:B:W99 21.222314.03YesYes199
90A:A:W211 B:B:L117 41.31035.69YesYes199
91A:A:C214 B:B:Y59 23.75119.41YesYes178
92A:A:C214 A:A:H213 23.57224.42YesYes178
93B:B:C271 B:B:Y289 21.61275.38NoYes157
94B:B:D290 B:B:R314 23.820716.68YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7XBW
Class A
SubFamily Protein
Type Chemokine
SubType CX3CR1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.8
Date 2022-07-13
D.O.I. doi.org/10.1126/sciadv.abn8048
Net Summary
Imin 2.95
Number of Linked Nodes 847
Number of Links 1029
Number of Hubs 168
Number of Links mediated by Hubs 608
Number of Communities 29
Number of Nodes involved in Communities 242
Number of Links involved in Communities 349
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 2239267
Length Of Smallest Path 3
Average Path Length 41.3717
Length of Longest Path 73
Minimum Path Strength 1.28
Average Path Strength 6.29782
Maximum Path Strength 24.18
Minimum Path Correlation 0.71
Average Path Correlation 0.986977
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 35.6218
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.6325
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • CX3C chemokine receptor binding   • signaling receptor binding   • cytokine receptor binding   • G protein-coupled receptor binding   • chemokine receptor binding   • G protein-coupled chemoattractant receptor activity   • molecular transducer activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • C-C chemokine binding   • chemokine binding   • cytokine binding   • C-X3-C chemokine receptor activity   • C-C chemokine receptor activity   • C-X3-C chemokine binding   • leukocyte tethering or rolling   • leukocyte cell-cell adhesion   • leukocyte migration   • cell adhesion   • cell-cell adhesion   • immune system process   • leukocyte adhesion to vascular endothelial cell   • cellular extravasation   • cell migration   • cell motility   • head development   • central nervous system development   • brain development   • nervous system development   • regulation of multicellular organismal development   • regulation of developmental process   • cellular developmental process   • cell development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of cell development   • regulation of nervous system development   • neurogenesis   • cell differentiation   • regulation of multicellular organismal process   • immune response   • adaptive immune response   • response to stress   • response to ischemia   • biological process involved in interspecies interaction between organisms   • response to other organism   • defense response   • defense response to symbiont   • response to external stimulus   • response to biotic stimulus   • defense response to other organism   • innate immune response   • response to external biotic stimulus   • autocrine signaling   • chemotaxis   • taxis   • locomotion   • antifungal innate immune response   • defense response to fungus   • response to fungus   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • cell chemotaxis   • positive regulation of monocyte chemotaxis   • positive regulation of locomotion   • regulation of cell motility   • regulation of response to external stimulus   • positive regulation of biological process   • positive regulation of chemotaxis   • positive regulation of cell migration   • regulation of monocyte chemotaxis   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • myeloid leukocyte migration   • positive regulation of mononuclear cell migration   • regulation of immune system process   • regulation of mononuclear cell migration   • positive regulation of immune system process   • positive regulation of cellular process   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • regulation of chemotaxis   • monocyte chemotaxis   • regulation of response to stimulus   • regulation of locomotion   • mononuclear cell migration   • leukocyte chemotaxis   • response to wounding   • developmental maturation   • synapse maturation   • cellular component organization   • cell junction organization   • synapse organization   • cellular component organization or biogenesis   • multicellular organismal-level homeostasis   • homeostatic process   • host-mediated modulation of intestinal microbiota composition   • homeostasis of number of cells   • modulation of process of another organism   • host-mediated perturbation of symbiont process   • cellular defense response   • positive regulation of nervous system development   • positive regulation of developmental process   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of cell development   • positive regulation of multicellular organismal process   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of canonical NF-kappaB signal transduction   • regulation of signal transduction   • regulation of intracellular signal transduction   • positive regulation of intracellular signal transduction   • canonical NF-kappaB signal transduction   • regulation of canonical NF-kappaB signal transduction   • positive regulation of signaling   • macrophage activation involved in immune response   • cell activation   • cell activation involved in immune response   • myeloid leukocyte activation   • myeloid cell activation involved in immune response   • leukocyte activation   • immune effector process   • macrophage activation   • microglial cell activation involved in immune response   • leukocyte activation involved in inflammatory response   • leukocyte activation involved in immune response   • microglial cell activation   • inflammatory response   • glial cell activation   • neuroinflammatory response   • interleukin-1 production   • negative regulation of biological process   • regulation of interleukin-1 beta production   • negative regulation of interleukin-1 beta production   • negative regulation of interleukin-1 production   • regulation of cytokine production   • cytokine production   • negative regulation of cellular process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • regulation of interleukin-1 production   • negative regulation of metabolic process   • negative regulation of cytokine production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • negative regulation of gene expression   • biosynthetic process   • negative regulation of biosynthetic process   • interleukin-1 beta production   • negative regulation of macromolecule biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • negative regulation of multicellular organismal process   • regulation of metabolic process   • cellular response to lipopolysaccharide   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • cellular response to biotic stimulus   • response to bacterium   • response to molecule of bacterial origin   • regulation of tumor necrosis factor production   • tumor necrosis factor superfamily cytokine production   • tumor necrosis factor production   • regulation of tumor necrosis factor superfamily cytokine production   • microglial cell mediated cytotoxicity   • regulation of immune effector process   • regulation of myeloid leukocyte mediated immunity   • myeloid leukocyte mediated immunity   • negative regulation of microglial cell mediated cytotoxicity   • negative regulation of leukocyte mediated cytotoxicity   • leukocyte mediated immunity   • negative regulation of cell killing   • negative regulation of myeloid leukocyte mediated immunity   • negative regulation of immune effector process   • regulation of leukocyte mediated cytotoxicity   • leukocyte mediated cytotoxicity   • regulation of leukocyte mediated immunity   • negative regulation of immune system process   • regulation of cell killing   • negative regulation of leukocyte mediated immunity   • regulation of microglial cell mediated cytotoxicity   • cell killing   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • calcium-mediated signaling   • cellular component disassembly   • cell junction disassembly   • synapse pruning   • regulation of nitric oxide biosynthetic process   • reactive nitrogen species metabolic process   • nitric oxide metabolic process   • nitric oxide biosynthetic process   • regulation of nitric oxide metabolic process   • negative regulation of signaling   • regulation of programmed cell death   • negative regulation of cell communication   • negative regulation of apoptotic signaling pathway   • negative regulation of response to stimulus   • negative regulation of programmed cell death   • regulation of apoptotic process   • cell death   • negative regulation of signal transduction   • apoptotic signaling pathway   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of apoptotic signaling pathway   • regulation of microglial cell migration   • glial cell migration   • macrophage migration   • regulation of glial cell migration   • regulation of macrophage migration   • gliogenesis   • microglial cell migration   • regulation of synaptic plasticity   • behavior   • biological process involved in intraspecies interaction between organisms   • social behavior   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of anatomical structure morphogenesis   • blood vessel development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • vasculature development   • circulatory system development   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • neuron apoptotic process   • negative regulation of neuron apoptotic process   • hippocampal neuron apoptotic process   • regulation of hippocampal neuron apoptotic process   • negative regulation of hippocampal neuron apoptotic process   • regulation of neuron apoptotic process   • central nervous system maturation   • anatomical structure maturation   • multiple spine synapse organization   • multiple spine synapse organization, single dendrite   • neuroblast proliferation   • positive regulation of cell population proliferation   • regulation of neuroblast proliferation   • regulation of neural precursor cell proliferation   • generation of neurons   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • positive regulation of neuroblast proliferation   • neural precursor cell proliferation   • cell surface   • external side of plasma membrane   • perinuclear region of cytoplasm   • somatodendritic compartment   • neuronal cell body membrane   • cell body   • cell body membrane   • neuronal cell body   • dendritic tree   • endosome membrane   • macropinosome membrane   • endosome   • intracellular vesicle   • macropinosome   • cytoplasmic vesicle membrane   • cytoplasmic vesicle   • vesicle membrane   • pinosome
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7XBW_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMKITGIV ETHFTFKDL HFKMFDVTA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHAS MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XBW_Chain_B
EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA 
KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM 
TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR ELAGHTGYL 
SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG HTGDVMSLS 
LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES DINAICFFP 
NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG ITSVSFSKS 
GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC LGVTDDGMA 
VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XBW_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49238
Sequence
>7XBW_Chain_R
IGDIVVFGT VFLSIFYSV IFAIGLVGN LLVVFALTN SKKPKSVTD 
IYLLNLALS DLLFVATLP FWTHYLINE KGLHNAMCK FTTAFFFIG 
FFGSIFFLT VISIDRYLA IVLAANSMN NRTVQHGVT ISLGVWAAA 
ILVAAPQFM FTKQKENEC LGDYPEVLQ EIWPVLRNV ETNFLGFLL 
PLLIMSYCY FRIIQTLFS SKNHKKAKA IKLILLVVI VFFLFWTPY 
NVVIFLETL KLYDFFPSC DMRKDLRLA LSVTETVAF SHCCLNPLI 
YAFAGEKFR RYLYHLYGK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XBWAProteinChemokineCX3CR1Homo sapiens--Gi1/β1/γ22.82022-07-13doi.org/10.1126/sciadv.abn8048
7XBW (No Gprot) AProteinChemokineCX3CR1Homo sapiens--2.82022-07-13doi.org/10.1126/sciadv.abn8048
7XBXAProteinChemokineCX3CR1Homo sapiensCX3CL1-Gi1/β1/γ23.42022-07-13doi.org/10.1126/sciadv.abn8048
7XBX (No Gprot) AProteinChemokineCX3CR1Homo sapiensCX3CL1-3.42022-07-13doi.org/10.1126/sciadv.abn8048




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