psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	4.13	Yes	Yes	1	0	0
2	L:L:?1	L:L:H3	9.63	Yes	Yes	1	0	0
3	L:L:?1	L:L:K36	4.53	Yes	No	1	0	0
4	L:L:?1	R:R:T106	3.15	Yes	Yes	1	0	4
5	L:L:?1	R:R:F110	9.12	Yes	Yes	1	0	5
6	L:L:?1	R:R:T168	3.15	Yes	Yes	1	0	5
7	L:L:?1	R:R:R191	16.89	Yes	No	1	0	5
8	L:L:H2	L:L:V5	6.92	Yes	No	1	0	0
9	L:L:H2	R:R:W87	9.52	Yes	Yes	1	0	6
10	L:L:H2	R:R:F109	20.36	Yes	Yes	0	0	7
11	L:L:H2	R:R:E279	8.62	Yes	Yes	0	0	5
12	L:L:H3	L:L:K36	2.62	Yes	No	1	0	0
13	L:L:H3	R:R:N192	3.83	Yes	Yes	1	0	5
14	L:L:H3	R:R:R272	4.51	Yes	No	0	0	4
15	L:L:G4	R:R:E279	6.55	No	Yes	0	0	5
16	L:L:V5	R:R:W87	8.58	No	Yes	1	0	6
17	L:L:V5	R:R:L91	7.45	No	No	0	0	5
18	L:L:C8	L:L:T6	8.45	No	No	7	0	0
19	L:L:C34	L:L:T6	5.07	No	No	7	0	0
20	L:L:K7	R:R:E94	2.7	No	No	1	0	4
21	L:L:K7	R:R:N173	8.39	No	Yes	1	0	3
22	L:L:C34	L:L:C8	7.28	No	No	7	0	0
23	L:L:I10	L:L:N9	9.91	No	No	0	0	0
24	L:L:N9	L:L:S33	7.45	No	No	0	0	0
25	L:L:I10	L:L:Q28	4.12	No	Yes	8	0	0
26	L:L:I10	L:L:I40	5.89	No	Yes	8	0	0
27	L:L:R37	L:L:T11	2.59	No	No	0	0	0
28	L:L:C12	L:L:I40	4.91	No	Yes	0	0	0
29	L:L:C12	L:L:C50	7.28	No	No	0	0	0
30	L:L:R37	L:L:S13	5.27	No	No	0	0	0
31	L:L:S13	R:R:R268	5.27	No	No	0	0	4
32	L:L:K14	L:L:M15	12.96	No	No	0	0	0
33	L:L:K14	R:R:R268	6.19	No	No	0	0	4
34	L:L:S17	L:L:T16	3.2	No	No	5	0	0
35	L:L:E55	L:L:T16	5.64	Yes	No	5	0	0
36	L:L:E55	L:L:S17	8.62	Yes	No	5	0	0
37	L:L:S17	L:L:W57	4.94	No	Yes	5	0	0
38	L:L:K18	L:L:L41	2.82	No	No	0	0	0
39	L:L:I19	L:L:P20	5.08	No	No	0	0	0
40	L:L:P20	L:L:W57	2.7	No	Yes	0	0	0
41	L:L:L23	L:L:V21	7.45	No	No	0	0	0
42	L:L:L24	L:L:L41	4.15	No	No	0	0	0
43	L:L:L24	L:L:M62	9.9	No	Yes	0	0	0
44	L:L:I25	L:L:R44	12.53	No	No	0	0	0
45	L:L:E42	L:L:H26	6.15	No	No	0	0	0
46	L:L:K59	L:L:Y27	5.97	No	No	9	0	0
47	L:L:M62	L:L:Y27	5.99	Yes	No	9	0	0
48	L:L:I40	L:L:Q28	8.23	Yes	Yes	8	0	0
49	L:L:E42	L:L:Q28	17.84	No	Yes	0	0	0
50	L:L:L48	L:L:Q28	3.99	No	Yes	0	0	0
51	L:L:N30	L:L:S33	4.47	No	No	0	0	0
52	L:L:N30	L:L:R37	6.03	No	No	0	0	0
53	L:L:I40	L:L:N30	8.5	Yes	No	0	0	0
54	L:L:I39	L:L:Q31	2.74	No	No	0	0	0
55	L:L:Q31	R:R:K171	2.71	No	Yes	0	0	3
56	L:L:A32	R:R:K171	3.21	No	Yes	0	0	3
57	L:L:C35	R:R:C176	7.28	No	Yes	0	0	3
58	L:L:Q45	L:L:T43	8.5	No	No	10	0	0
59	L:L:F49	L:L:T43	5.19	No	No	10	0	0
60	L:L:F49	L:L:Q45	11.71	No	No	10	0	0
61	L:L:F49	L:L:R47	10.69	No	No	0	0	0
62	L:L:R47	R:R:Y22	4.12	No	No	0	0	2
63	L:L:L48	R:R:Y22	5.86	No	No	0	0	2
64	L:L:E55	L:L:W57	13.08	Yes	Yes	5	0	0
65	L:L:E55	L:L:V58	2.85	Yes	No	5	0	0
66	L:L:V58	L:L:W57	6.13	No	Yes	5	0	0
67	L:L:K59	L:L:M62	2.88	No	Yes	9	0	0
68	L:L:K59	L:L:Q63	5.42	No	No	0	0	0
69	L:L:D66	L:L:M62	5.54	No	Yes	0	0	0
70	R:R:G24	R:R:I23	3.53	No	No	0	3	5
71	R:R:I23	R:R:V27	4.61	No	No	0	5	2
72	R:R:I26	R:R:V27	3.07	No	No	0	5	2
73	R:R:I26	R:R:K269	7.27	No	No	0	5	1
74	R:R:L91	R:R:T31	5.9	No	No	0	5	5
75	R:R:L34	R:R:Y38	11.72	No	Yes	1	5	7
76	R:R:L34	R:R:T280	2.95	No	No	1	5	5
77	R:R:I36	R:R:S39	3.1	No	No	0	6	5
78	R:R:F37	R:R:T280	2.59	No	No	0	5	5
79	R:R:L84	R:R:Y38	15.24	Yes	Yes	1	7	7
80	R:R:T88	R:R:Y38	3.75	No	Yes	1	6	7
81	R:R:T280	R:R:Y38	6.24	No	Yes	1	5	7
82	R:R:F283	R:R:Y38	15.47	Yes	Yes	1	6	7
83	R:R:F283	R:R:I41	16.33	Yes	Yes	0	6	7
84	R:R:C287	R:R:I41	4.91	No	Yes	0	8	7
85	R:R:F42	R:R:L46	7.31	No	No	0	7	6
86	R:R:F42	R:R:V81	7.87	No	No	0	7	6
87	R:R:F42	R:R:P85	10.11	No	No	0	7	8
88	R:R:G45	R:R:I44	3.53	No	No	0	8	5
89	R:R:C287	R:R:I44	3.27	No	No	0	8	5
90	R:R:G48	R:R:P290	4.06	No	No	0	8	9
91	R:R:D77	R:R:N49	12.12	No	No	0	9	9
92	R:R:L78	R:R:N49	5.49	No	No	0	7	9
93	R:R:N49	R:R:P290	3.26	No	No	0	9	9
94	R:R:F300	R:R:L51	3.65	Yes	No	2	8	6
95	R:R:L304	R:R:L51	4.15	No	No	2	7	6
96	R:R:L307	R:R:L51	2.77	No	No	2	5	6
97	R:R:F300	R:R:V52	5.24	Yes	No	0	8	8
98	R:R:F54	R:R:Y303	3.09	No	Yes	0	4	4
99	R:R:A55	R:R:Y303	8.01	No	Yes	0	7	4
100	R:R:L56	R:R:L70	5.54	No	No	0	7	8
101	R:R:L56	R:R:L71	5.54	No	No	0	7	6
102	R:R:N58	R:R:Y303	3.49	No	Yes	0	5	4
103	R:R:K61	R:R:P62	3.35	No	No	0	5	6
104	R:R:K63	R:R:P62	3.35	No	No	0	6	6
105	R:R:K63	R:R:V143	13.66	No	No	0	6	4
106	R:R:D67	R:R:S64	10.31	No	No	0	8	8
107	R:R:D126	R:R:V65	4.38	No	No	11	8	6
108	R:R:R141	R:R:V65	5.23	No	No	11	6	6
109	R:R:R127	R:R:T66	6.47	No	No	0	9	8
110	R:R:V122	R:R:Y69	6.31	No	Yes	0	7	7
111	R:R:I123	R:R:Y69	4.84	No	Yes	0	9	7
112	R:R:G146	R:R:Y69	2.9	No	Yes	0	7	7
113	R:R:I149	R:R:Y69	7.25	No	Yes	0	5	7
114	R:R:L70	R:R:Y293	7.03	No	Yes	0	8	9
115	R:R:L71	R:R:L75	4.15	No	No	0	6	6
116	R:R:F119	R:R:N72	13.29	Yes	Yes	3	8	9
117	R:R:N72	R:R:S150	10.43	Yes	No	3	9	8
118	R:R:N72	R:R:W154	6.78	Yes	No	3	9	9
119	R:R:L73	R:R:S116	4.5	No	No	0	9	9
120	R:R:L120	R:R:L73	2.77	No	No	0	9	9
121	R:R:G115	R:R:S76	3.71	No	Yes	3	7	8
122	R:R:S116	R:R:S76	3.26	No	Yes	0	9	8
123	R:R:F119	R:R:S76	2.64	Yes	Yes	3	8	8
124	R:R:S76	R:R:W154	4.94	Yes	No	3	8	9
125	R:R:C286	R:R:D77	6.22	No	No	0	8	9
126	R:R:G112	R:R:L79	3.42	No	No	0	8	7
127	R:R:F109	R:R:F80	6.43	Yes	No	0	7	7
128	R:R:F283	R:R:F80	15	Yes	No	0	6	7
129	R:R:C286	R:R:F80	13.97	No	No	0	8	7
130	R:R:F283	R:R:V81	2.62	Yes	No	0	6	6
131	R:R:T105	R:R:T83	4.71	No	No	0	5	7
132	R:R:F108	R:R:T83	2.59	No	No	0	5	7
133	R:R:F109	R:R:T83	3.89	Yes	No	0	7	7
134	R:R:L84	R:R:P85	4.93	Yes	No	0	7	8
135	R:R:L84	R:R:W87	3.42	Yes	Yes	1	7	6
136	R:R:L84	R:R:T88	7.37	Yes	No	1	7	6
137	R:R:F283	R:R:L84	14.61	Yes	Yes	1	6	7
138	R:R:F86	R:R:T105	12.97	No	No	0	7	5
139	R:R:C102	R:R:W87	2.61	Yes	Yes	1	9	6
140	R:R:T105	R:R:W87	12.13	No	Yes	0	5	6
141	R:R:T106	R:R:W87	8.49	Yes	Yes	1	4	6
142	R:R:C175	R:R:W87	5.22	Yes	Yes	1	9	6
143	R:R:H89	R:R:N93	8.93	No	No	0	4	3
144	R:R:G96	R:R:Y90	10.14	Yes	Yes	1	3	5
145	R:R:C102	R:R:Y90	6.72	Yes	Yes	1	9	5
146	R:R:Q170	R:R:Y90	7.89	Yes	Yes	1	5	5
147	R:R:N173	R:R:Y90	3.49	Yes	Yes	1	3	5
148	R:R:I92	R:R:N93	4.25	No	No	0	4	3
149	R:R:K95	R:R:N93	11.19	No	No	0	8	3
150	R:R:E94	R:R:N173	3.94	No	Yes	1	4	3
151	R:R:G96	R:R:K95	3.49	Yes	No	0	3	8
152	R:R:G96	R:R:L97	3.42	Yes	No	0	3	7
153	R:R:G96	R:R:Q170	3.29	Yes	Yes	1	3	5
154	R:R:L97	R:R:M101	12.72	No	No	0	7	6
155	R:R:N99	R:R:Q170	7.92	No	Yes	0	2	5
156	R:R:F104	R:R:M101	3.73	No	No	0	4	6
157	R:R:C102	R:R:Q170	7.63	Yes	Yes	1	9	5
158	R:R:C102	R:R:C175	7.28	Yes	Yes	1	9	9
159	R:R:K103	R:R:T168	3	No	Yes	0	7	5
160	R:R:F104	R:R:F108	10.72	No	No	0	4	5
161	R:R:F110	R:R:T106	3.89	Yes	Yes	1	5	4
162	R:R:T106	R:R:T168	3.14	Yes	Yes	1	4	5
163	R:R:C175	R:R:T106	5.07	Yes	Yes	1	9	4
164	R:R:A107	R:R:F165	8.32	No	No	0	5	5
165	R:R:F109	R:R:F110	5.36	Yes	Yes	0	7	5
166	R:R:F110	R:R:Q164	23.42	Yes	Yes	1	5	4
167	R:R:F110	R:R:R191	3.21	Yes	No	1	5	5
168	R:R:G112	R:R:I111	3.53	No	No	0	8	5
169	R:R:I111	R:R:I158	5.89	No	No	0	5	4
170	R:R:A161	R:R:I111	3.25	No	No	0	7	5
171	R:R:F113	R:R:F114	6.43	Yes	Yes	1	8	7
172	R:R:F113	R:R:I117	8.79	Yes	Yes	1	8	8
173	R:R:F113	R:R:T195	2.59	Yes	Yes	1	8	5
174	R:R:F113	R:R:W244	12.03	Yes	Yes	0	8	9
175	R:R:F114	R:R:I117	3.77	Yes	Yes	1	7	8
176	R:R:F114	R:R:F118	5.36	Yes	Yes	1	7	6
177	R:R:F114	R:R:V160	11.8	Yes	Yes	1	7	5
178	R:R:F114	R:R:Q164	12.88	Yes	Yes	1	7	4
179	R:R:F114	R:R:T195	3.89	Yes	Yes	1	7	5
180	R:R:F119	R:R:G115	3.01	Yes	No	3	8	7
181	R:R:F118	R:R:I117	6.28	Yes	Yes	1	6	8
182	R:R:F240	R:R:I117	5.02	No	Yes	0	9	8
183	R:R:F118	R:R:V153	3.93	Yes	No	0	6	7
184	R:R:A157	R:R:F118	2.77	No	Yes	0	7	6
185	R:R:F118	R:R:V160	3.93	Yes	Yes	1	6	5
186	R:R:F119	R:R:S150	2.64	Yes	No	3	8	8
187	R:R:F119	R:R:V153	7.87	Yes	No	0	8	7
188	R:R:F119	R:R:W154	16.04	Yes	No	3	8	9
189	R:R:F240	R:R:L120	8.53	No	No	0	9	9
190	R:R:P203	R:R:T121	3.5	No	No	0	9	7
191	R:R:M207	R:R:T121	3.01	Yes	No	0	8	7
192	R:R:M207	R:R:S124	6.13	Yes	No	0	8	9
193	R:R:C210	R:R:S124	3.44	No	No	0	7	9
194	R:R:S124	R:R:Y211	6.36	No	Yes	0	9	9
195	R:R:I125	R:R:I206	2.94	No	No	0	6	6
196	R:R:C210	R:R:I125	3.27	No	No	0	7	6
197	R:R:D126	R:R:R127	3.57	No	No	0	8	9
198	R:R:D126	R:R:R141	8.34	No	No	11	8	6
199	R:R:V132	R:R:Y128	10.09	No	No	0	7	8
200	R:R:C210	R:R:Y128	5.38	No	No	0	7	8
201	R:R:R213	R:R:Y128	6.17	No	No	0	4	8
202	R:R:L129	R:R:L133	2.77	No	No	0	5	6
203	R:R:I131	R:R:I214	11.77	No	No	0	8	8
204	R:R:I131	R:R:T217	3.04	No	No	0	8	5
205	R:R:L133	R:R:V132	5.96	No	No	0	6	7
206	R:R:T217	R:R:V132	4.76	No	No	0	5	7
207	R:R:N136	R:R:N140	6.81	No	No	0	4	4
208	R:R:M138	R:R:N139	4.21	No	No	0	4	4
209	R:R:H145	R:R:T148	4.11	No	No	0	3	3
210	R:R:H145	R:R:I149	6.63	No	No	0	3	5
211	R:R:E194	R:R:V160	4.28	No	Yes	0	4	5
212	R:R:A162	R:R:M166	3.22	No	No	0	4	4
213	R:R:E194	R:R:P163	6.29	No	No	0	4	8
214	R:R:Q164	R:R:R191	10.51	Yes	No	1	4	5
215	R:R:Q164	R:R:T195	2.83	Yes	Yes	1	4	5
216	R:R:F167	R:R:M166	4.98	No	No	0	5	4
217	R:R:F167	R:R:P180	10.11	No	No	0	5	5
218	R:R:F167	R:R:W187	13.03	No	No	0	5	4
219	R:R:C175	R:R:T168	3.38	Yes	Yes	1	9	5
220	R:R:D178	R:R:K169	2.77	No	No	0	4	4
221	R:R:E172	R:R:K171	6.75	No	Yes	0	1	3
222	R:R:E174	R:R:K171	4.05	No	Yes	1	1	3
223	R:R:C176	R:R:K171	4.85	Yes	Yes	1	3	3
224	R:R:E174	R:R:N173	2.63	No	Yes	1	1	3
225	R:R:C176	R:R:E174	4.56	Yes	No	1	3	1
226	R:R:C176	R:R:G177	3.92	Yes	No	0	3	4
227	R:R:Q184	R:R:Y179	12.4	No	No	0	3	5
228	R:R:L183	R:R:V182	4.47	No	No	0	2	3
229	R:R:L183	R:R:W187	18.22	No	No	0	2	4
230	R:R:E185	R:R:Q184	7.65	No	No	0	1	3
231	R:R:I186	R:R:W187	4.7	No	No	0	2	4
232	R:R:I186	R:R:L190	2.85	No	No	0	2	5
233	R:R:E194	R:R:L190	7.95	No	No	0	4	5
234	R:R:I251	R:R:N192	5.66	Yes	Yes	1	6	5
235	R:R:E254	R:R:N192	13.15	No	Yes	1	4	5
236	R:R:N192	R:R:T255	8.77	Yes	No	1	5	5
237	R:R:F197	R:R:V193	7.87	No	No	0	4	5
238	R:R:I251	R:R:T195	3.04	Yes	Yes	1	6	5
239	R:R:N196	R:R:N248	6.81	No	No	0	5	8
240	R:R:F252	R:R:N196	4.83	No	No	0	6	5
241	R:R:F200	R:R:L204	4.87	Yes	Yes	6	9	7
242	R:R:F200	R:R:F241	6.43	Yes	Yes	6	9	6
243	R:R:F200	R:R:T245	2.59	Yes	No	0	9	6
244	R:R:F200	R:R:N248	15.71	Yes	No	0	9	8
245	R:R:L202	R:R:P203	4.93	No	No	0	5	9
246	R:R:I206	R:R:L202	2.85	No	No	0	6	5
247	R:R:F241	R:R:L204	9.74	Yes	Yes	6	6	7
248	R:R:M207	R:R:V237	7.61	Yes	No	6	8	8
249	R:R:F241	R:R:M207	6.22	Yes	Yes	6	6	8
250	R:R:R213	R:R:Y209	14.4	No	No	0	4	5
251	R:R:I230	R:R:Y211	6.04	No	Yes	0	5	9
252	R:R:I233	R:R:Y211	6.04	No	Yes	0	8	9
253	R:R:L234	R:R:Y211	9.38	No	Yes	0	4	9
254	R:R:V237	R:R:Y211	8.83	No	Yes	0	8	9
255	R:R:F212	R:R:Q216	14.05	No	No	0	3	3
256	R:R:I214	R:R:L218	2.85	No	No	0	8	8
257	R:R:I214	R:R:I230	8.83	No	No	0	8	5
258	R:R:F219	R:R:I215	7.54	No	No	0	4	5
259	R:R:L218	R:R:N223	2.75	No	No	0	8	3
260	R:R:A227	R:R:L218	4.73	No	No	0	5	8
261	R:R:F219	R:R:H224	9.05	No	Yes	0	4	3
262	R:R:N223	R:R:S221	11.92	No	No	0	3	5
263	R:R:K222	R:R:K226	2.87	No	No	0	4	5
264	R:R:H224	R:R:K225	3.93	Yes	No	0	3	5
265	R:R:H224	R:R:K231	5.24	Yes	No	0	3	6
266	R:R:K225	R:R:K226	4.31	No	No	0	5	5
267	R:R:K226	R:R:K228	2.87	No	No	0	5	7
268	R:R:I233	R:R:L232	2.85	No	No	0	8	8
269	R:R:A296	R:R:L232	4.73	No	No	0	6	8
270	R:R:N289	R:R:V236	5.91	Yes	No	2	9	7
271	R:R:V236	R:R:Y293	5.05	No	Yes	2	7	9
272	R:R:F241	R:R:V237	3.93	Yes	No	6	6	8
273	R:R:F243	R:R:V239	2.62	No	No	2	8	7
274	R:R:H285	R:R:V239	6.92	No	No	2	9	7
275	R:R:F240	R:R:W244	15.03	No	Yes	0	9	9
276	R:R:F243	R:R:V281	5.24	No	No	0	8	7
277	R:R:F243	R:R:H285	21.5	No	No	2	8	9
278	R:R:W244	R:R:Y247	8.68	Yes	Yes	0	9	7
279	R:R:A282	R:R:W244	7.78	No	Yes	0	8	9
280	R:R:P246	R:R:T245	3.5	No	No	0	9	6
281	R:R:P246	R:R:T278	6.99	No	No	0	9	6
282	R:R:I251	R:R:Y247	6.04	Yes	Yes	0	6	7
283	R:R:T278	R:R:Y247	7.49	No	Yes	0	6	7
284	R:R:E279	R:R:Y247	7.86	Yes	Yes	0	5	7
285	R:R:V249	R:R:V250	3.21	No	No	0	6	5
286	R:R:L275	R:R:V250	5.96	No	No	0	5	5
287	R:R:E254	R:R:I251	6.83	No	Yes	1	4	6
288	R:R:F252	R:R:L256	3.65	No	No	0	6	5
289	R:R:F262	R:R:L253	6.09	Yes	No	4	1	5
290	R:R:L253	R:R:L271	4.15	No	No	4	5	5
291	R:R:E254	R:R:T255	5.64	No	No	1	4	5
292	R:R:F261	R:R:L256	9.74	No	No	0	1	5
293	R:R:D260	R:R:K257	5.53	No	Yes	4	1	3
294	R:R:K257	R:R:P263	3.35	Yes	No	4	3	3
295	R:R:K257	R:R:R268	11.14	Yes	No	0	3	4
296	R:R:D260	R:R:P263	3.22	No	No	4	1	3
297	R:R:F261	R:R:F262	9.65	No	Yes	0	1	1
298	R:R:F262	R:R:L271	9.74	Yes	No	4	1	5
299	R:R:M267	R:R:S264	9.2	No	No	0	1	5
300	R:R:D270	R:R:L271	5.43	No	No	0	2	5
301	R:R:L275	R:R:R272	9.72	No	No	0	5	4
302	R:R:L273	R:R:V277	2.98	No	No	0	1	5
303	R:R:E279	R:R:L275	5.3	Yes	No	0	5	5
304	R:R:S276	R:R:V277	3.23	No	No	0	5	5
305	R:R:I292	R:R:L288	7.14	No	No	0	8	7
306	R:R:N289	R:R:P290	3.26	Yes	No	0	9	9
307	R:R:N289	R:R:Y293	6.98	Yes	Yes	2	9	9
308	R:R:F295	R:R:L291	13.4	No	No	0	7	6
309	R:R:A294	R:R:F300	2.77	No	Yes	0	7	8
310	R:R:F300	R:R:L304	7.31	Yes	No	2	8	7
311	R:R:R301	R:R:Y305	10.29	No	No	0	8	3
312	R:R:H306	R:R:Y303	4.36	No	Yes	2	4	4
313	R:R:L307	R:R:Y303	5.86	No	Yes	2	5	4
314	R:R:H306	R:R:L307	6.43	No	No	2	4	5
315	R:R:H285	R:R:N289	2.55	No	Yes	2	9	9
316	R:R:V65	R:R:Y69	2.52	No	Yes	0	6	7
317	R:R:I23	R:R:R272	2.51	No	No	0	5	4
318	R:R:F37	R:R:I36	2.51	No	No	0	5	6
319	R:R:F262	R:R:M267	2.49	Yes	No	0	1	1
320	R:R:F262	R:R:K257	2.48	Yes	Yes	4	1	3
321	R:R:F197	R:R:L201	2.44	No	No	0	4	4
322	L:L:I39	L:L:Y27	2.42	No	No	0	0	0
323	R:R:F33	R:R:F37	2.14	No	No	0	5	5
324	R:R:F300	R:R:Y293	2.06	Yes	Yes	2	8	9
325	R:R:G199	R:R:P203	2.03	No	No	0	6	9
326	R:R:A155	R:R:G152	1.95	No	No	0	5	4
327	R:R:A296	R:R:G297	1.95	No	No	0	6	8
328	L:L:A61	L:L:P20	1.87	No	No	0	0	0
329	R:R:G112	R:R:S76	1.86	No	Yes	0	8	8
330	R:R:G48	R:R:V47	1.84	No	No	0	8	4
331	L:L:C34	L:L:S33	1.72	No	No	0	0	0
332	R:R:A134	R:R:S137	1.71	No	No	0	7	6
333	R:R:G152	R:R:L151	1.71	No	No	0	4	4
334	R:R:A74	R:R:V52	1.7	No	No	0	9	8
335	R:R:A74	R:R:V53	1.7	No	No	0	9	7
336	R:R:A274	R:R:V250	1.7	No	No	0	6	5
337	R:R:N192	R:R:P188	1.63	Yes	No	0	5	4
338	R:R:D178	R:R:P180	1.61	No	No	0	4	5
339	R:R:V27	R:R:V28	1.6	No	No	0	2	4
340	R:R:S64	R:R:T66	1.6	No	No	0	8	8
341	R:R:V122	R:R:V153	1.6	No	No	0	7	7
342	R:R:T57	R:R:V53	1.59	No	No	0	3	7
343	R:R:T255	R:R:V189	1.59	No	No	0	5	3
344	R:R:I41	R:R:S284	1.55	Yes	No	0	7	5
345	L:L:I19	L:L:V21	1.54	No	No	0	0	0
346	L:L:A61	L:L:D60	1.54	No	No	0	0	0
347	R:R:I41	R:R:V40	1.54	Yes	No	0	7	5
348	R:R:I292	R:R:V236	1.54	No	No	0	8	7
349	R:R:I238	R:R:V239	1.54	No	No	0	5	7
350	R:R:K61	R:R:S64	1.53	No	No	0	5	8
351	L:L:A32	L:L:Q29	1.52	No	No	0	0	0
352	R:R:F29	R:R:G30	1.51	No	No	0	7	4
353	R:R:L129	R:R:S137	1.5	No	No	0	5	6
354	R:R:L204	R:R:S208	1.5	Yes	No	0	7	5
355	L:L:L24	L:L:V21	1.49	No	No	0	0	0
356	R:R:N136	R:R:S137	1.49	No	No	0	4	6
357	R:R:L198	R:R:V160	1.49	No	Yes	0	5	5
358	R:R:L190	R:R:V193	1.49	No	No	0	5	5
359	R:R:D67	R:R:S59	1.47	No	No	0	8	5
360	R:R:D266	R:R:S264	1.47	No	No	0	2	5
361	R:R:A227	R:R:H224	1.46	No	Yes	0	5	3
362	R:R:Q144	R:R:V143	1.43	No	No	0	4	4
363	R:R:I238	R:R:L242	1.43	No	No	0	5	5
364	R:R:I68	R:R:N72	1.42	No	Yes	0	6	9
365	R:R:Q144	R:R:T142	1.42	No	No	0	4	6
366	R:R:K231	R:R:L235	1.41	No	No	0	6	6
367	R:R:A156	R:R:F118	1.39	No	Yes	0	4	6
368	R:R:A162	R:R:F165	1.39	No	No	0	4	5
369	R:R:P180	R:R:Y179	1.39	No	No	0	5	5
370	R:R:L46	R:R:L50	1.38	No	No	0	6	4
371	R:R:A130	R:R:R127	1.38	No	No	0	8	9
372	R:R:A130	R:R:R141	1.38	No	No	0	8	6
373	R:R:L201	R:R:L205	1.38	No	No	0	4	3
374	R:R:L204	R:R:L205	1.38	Yes	No	0	7	3
375	R:R:L288	R:R:L291	1.38	No	No	0	7	6
376	L:L:E42	L:L:I25	1.37	No	No	0	0	0
377	R:R:F29	R:R:V32	1.31	No	No	0	7	5
378	R:R:F33	R:R:V32	1.31	No	No	0	5	5
379	L:L:H64	L:L:L65	1.29	No	No	0	0	0
380	R:R:K299	R:R:Y303	1.19	No	Yes	0	6	4
381	R:R:Q216	R:R:R213	1.17	No	No	0	3	4
382	R:R:H306	R:R:R302	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.22857	7	1	0
2	L:L:H2	9.91	5	1	0
3	L:L:H3	5.1475	4	1	0
4	L:L:Q28	8.545	4	8	0
5	L:L:I40	6.8825	4	8	0
6	L:L:E55	7.5475	4	5	0
7	L:L:W57	6.7125	4	5	0
8	L:L:M62	6.0775	4	9	0
9	R:R:Y38	10.484	5	1	7
10	R:R:I41	6.0825	4	0	7
11	R:R:Y69	4.764	5	0	7
12	R:R:N72	7.98	4	3	9
13	R:R:S76	3.282	5	3	8
14	R:R:L84	9.114	5	1	7
15	R:R:W87	7.13857	7	1	6
16	R:R:Y90	7.06	4	1	5
17	R:R:G96	5.085	4	1	3
18	R:R:C102	6.06	4	1	9
19	R:R:T106	4.748	5	1	4
20	R:R:F109	9.01	4	0	7
21	R:R:F110	9	5	1	5
22	R:R:F113	7.46	4	1	8
23	R:R:F114	7.355	6	1	7
24	R:R:I117	5.965	4	1	8
25	R:R:F118	3.94333	6	1	6
26	R:R:F119	7.58167	6	3	8
27	R:R:V160	5.375	4	1	5
28	R:R:Q164	12.41	4	1	4
29	R:R:T168	3.1675	4	1	5
30	R:R:Q170	6.6825	4	1	5
31	R:R:K171	4.314	5	1	3
32	R:R:N173	4.6125	4	1	3
33	R:R:C175	5.2375	4	1	9
34	R:R:C176	5.1525	4	1	3
35	R:R:N192	6.608	5	1	5
36	R:R:T195	3.0875	4	1	5
37	R:R:F200	7.4	4	6	9
38	R:R:L204	4.3725	4	6	7
39	R:R:M207	5.7425	4	6	8
40	R:R:Y211	7.33	5	0	9
41	R:R:H224	4.92	4	0	3
42	R:R:F241	6.58	4	6	6
43	R:R:W244	10.88	4	0	9
44	R:R:Y247	7.5175	4	0	7
45	R:R:I251	5.3925	4	1	6
46	R:R:K257	5.625	4	4	3
47	R:R:F262	6.09	5	4	1
48	R:R:E279	7.0825	4	0	5
49	R:R:F283	12.806	5	1	6
50	R:R:N289	4.675	4	2	9
51	R:R:Y293	5.28	4	2	9
52	R:R:F300	4.206	5	2	8
53	R:R:Y303	4.33333	6	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	11.202	4.13	Yes	Yes	1	0	0
2	L:L:H2	R:R:W87	41.2657	9.52	Yes	Yes	1	0	6
3	R:R:T106	R:R:W87	20.6052	8.49	Yes	Yes	1	4	6
4	L:L:H2	R:R:F109	32.2001	20.36	Yes	Yes	0	0	7
5	R:R:F109	R:R:F110	21.5826	5.36	Yes	Yes	0	7	5
6	L:L:H2	R:R:E279	55.7341	8.62	Yes	Yes	0	0	5
7	L:L:?1	L:L:H3	19.024	9.63	Yes	Yes	1	0	0
8	L:L:H3	R:R:R272	13.1307	4.51	Yes	No	0	0	4
9	R:R:E279	R:R:Y247	58.2083	7.86	Yes	Yes	0	5	7
10	R:R:T278	R:R:Y247	100	7.49	No	Yes	0	6	7
11	R:R:P246	R:R:T278	99.1493	6.99	No	No	0	9	6
12	R:R:P246	R:R:T245	98.3505	3.5	No	No	0	9	6
13	R:R:F200	R:R:T245	97.6557	2.59	Yes	No	0	9	6
14	R:R:F200	R:R:N248	54.5555	15.71	Yes	No	0	9	8
15	R:R:N196	R:R:N248	53.3866	6.81	No	No	0	5	8
16	R:R:F252	R:R:N196	52.2112	4.83	No	No	0	6	5
17	R:R:F252	R:R:L256	51.0293	3.65	No	No	0	6	5
18	R:R:F261	R:R:L256	49.8409	9.74	No	No	0	1	5
19	R:R:F261	R:R:F262	48.646	9.65	No	Yes	0	1	1
20	R:R:F262	R:R:K257	40.1	2.48	Yes	Yes	4	1	3
21	R:R:K257	R:R:R268	36.34	11.14	Yes	No	0	3	4
22	L:L:S13	R:R:R268	32.5216	5.27	No	No	0	0	4
23	L:L:R37	L:L:S13	31.2358	5.27	No	No	0	0	0
24	L:L:N30	L:L:R37	28.6447	6.03	No	No	0	0	0
25	R:R:C102	R:R:W87	53.3281	2.61	Yes	Yes	1	9	6
26	R:R:C102	R:R:Y90	57.4096	6.72	Yes	Yes	1	9	5
27	R:R:N173	R:R:Y90	48.7856	3.49	Yes	Yes	1	3	5
28	R:R:C175	R:R:T106	14.1048	5.07	Yes	Yes	1	9	4
29	R:R:C102	R:R:C175	16.7089	7.28	Yes	Yes	1	9	9
30	L:L:I40	L:L:N30	20.6377	8.5	Yes	No	0	0	0
31	L:L:I40	L:L:Q28	15.2835	8.23	Yes	Yes	8	0	0
32	R:R:E174	R:R:N173	44.6263	2.63	No	Yes	1	1	3
33	R:R:E174	R:R:K171	38.7363	4.05	No	Yes	1	1	3
34	L:L:Q31	R:R:K171	33.2424	2.71	No	Yes	0	0	3
35	L:L:I39	L:L:Q31	31.8397	2.74	No	No	0	0	0
36	L:L:I39	L:L:Y27	30.3753	2.42	No	No	0	0	0
37	L:L:M62	L:L:Y27	25.9368	5.99	Yes	No	9	0	0
38	L:L:L24	L:L:M62	23.0729	9.9	No	Yes	0	0	0
39	L:L:L24	L:L:V21	18.6213	1.49	No	No	0	0	0
40	L:L:I19	L:L:V21	15.5822	1.54	No	No	0	0	0
41	L:L:I19	L:L:P20	14.0529	5.08	No	No	0	0	0
42	R:R:I23	R:R:R272	16.0497	2.51	No	No	0	5	4
43	R:R:I23	R:R:V27	10.7247	4.61	No	No	0	5	2
44	R:R:L84	R:R:W87	27.0472	3.42	Yes	Yes	1	7	6
45	R:R:T280	R:R:Y38	10.9845	6.24	No	Yes	1	5	7
46	R:R:F283	R:R:L84	12.4554	14.61	Yes	Yes	1	6	7
47	R:R:F109	R:R:F80	48.1525	6.43	Yes	No	0	7	7
48	R:R:F283	R:R:F80	18.9558	15	Yes	No	0	6	7
49	R:R:C286	R:R:F80	47.7726	13.97	No	No	0	8	7
50	R:R:C286	R:R:D77	46.7011	6.22	No	No	0	8	9
51	R:R:D77	R:R:N49	45.6231	12.12	No	No	0	9	9
52	R:R:N49	R:R:P290	43.4476	3.26	No	No	0	9	9
53	R:R:N289	R:R:P290	40.1357	3.26	Yes	No	0	9	9
54	R:R:N289	R:R:Y293	25.9432	6.98	Yes	Yes	2	9	9
55	R:R:F300	R:R:Y293	20.3163	2.06	Yes	Yes	2	8	9
56	R:R:F300	R:R:L51	11.5722	3.65	Yes	No	2	8	6
57	R:R:L307	R:R:L51	10.3318	2.77	No	No	2	5	6
58	R:R:F110	R:R:Q164	48.2888	23.42	Yes	Yes	1	5	4
59	R:R:F114	R:R:Q164	49.3149	12.88	Yes	Yes	1	7	4
60	R:R:F114	R:R:F118	52.3605	5.36	Yes	Yes	1	7	6
61	R:R:F118	R:R:V153	75.4984	3.93	Yes	No	0	6	7
62	R:R:V122	R:R:V153	53.8704	1.6	No	No	0	7	7
63	R:R:V122	R:R:Y69	51.4709	6.31	No	Yes	0	7	7
64	R:R:V65	R:R:Y69	37.1128	2.52	No	Yes	0	6	7
65	R:R:D126	R:R:V65	29.8364	4.38	No	No	11	8	6
66	R:R:D126	R:R:R127	27.4271	3.57	No	No	0	8	9
67	R:R:R127	R:R:T66	25.0276	6.47	No	No	0	9	8
68	R:R:S64	R:R:T66	22.5567	1.6	No	No	0	8	8
69	R:R:K61	R:R:S64	15.0951	1.53	No	No	0	5	8
70	R:R:K61	R:R:P62	12.595	3.35	No	No	0	5	6
71	R:R:K63	R:R:P62	10.0883	3.35	No	No	0	6	6
72	R:R:F119	R:R:V153	21.3293	7.87	Yes	No	0	8	7
73	R:R:W244	R:R:Y247	41.8988	8.68	Yes	Yes	0	9	7
74	R:R:F240	R:R:W244	17.3875	15.03	No	Yes	0	9	9
75	R:R:F240	R:R:I117	12.6372	5.02	No	Yes	0	9	8
76	R:R:G96	R:R:K95	12.0755	3.49	Yes	No	0	3	8
77	R:R:C102	R:R:Q170	11.3514	7.63	Yes	Yes	1	9	5
78	R:R:F114	R:R:V160	21.0306	11.8	Yes	Yes	1	7	5
79	R:R:E194	R:R:V160	27.6836	4.28	No	Yes	0	4	5
80	R:R:E194	R:R:L190	26.3264	7.95	No	No	0	4	5
81	R:R:I186	R:R:L190	20.5987	2.85	No	No	0	2	5
82	R:R:I186	R:R:W187	19.2707	4.7	No	No	0	2	4
83	R:R:F167	R:R:W187	15.2477	13.03	No	No	0	5	4
84	R:R:F113	R:R:F114	12.9554	6.43	Yes	Yes	1	8	7
85	R:R:F200	R:R:F241	56.5946	6.43	Yes	Yes	6	9	6
86	R:R:F241	R:R:M207	31.5995	6.22	Yes	Yes	6	6	8
87	R:R:M207	R:R:S124	24.0145	6.13	Yes	No	0	8	9
88	R:R:C210	R:R:S124	22.8911	3.44	No	No	0	7	9
89	R:R:F241	R:R:V237	32.7846	3.93	Yes	No	6	6	8
90	R:R:V237	R:R:Y211	31.869	8.83	No	Yes	0	8	9
91	R:R:C210	R:R:Y128	18.6993	5.38	No	No	0	7	8
92	R:R:V132	R:R:Y128	11.8644	10.09	No	No	0	7	8
93	R:R:I230	R:R:Y211	24.4789	6.04	No	Yes	0	5	9
94	R:R:I214	R:R:I230	23.1671	8.83	No	No	0	8	5
95	R:R:L190	R:R:V193	14.6893	1.49	No	No	0	5	5
96	R:R:F197	R:R:V193	13.9165	7.87	No	No	0	4	5
97	R:R:I214	R:R:L218	19.4948	2.85	No	No	0	8	8
98	R:R:A227	R:R:L218	15.0919	4.73	No	No	0	5	8
99	R:R:A227	R:R:H224	13.6113	1.46	No	Yes	0	5	3
100	R:R:E279	R:R:L275	11.4391	5.3	Yes	No	0	5	5
101	R:R:F197	R:R:L201	13.1664	2.44	No	No	0	4	4
102	R:R:L204	R:R:L205	13.5074	1.38	Yes	No	0	7	3
103	R:R:F113	R:R:W244	23.7873	12.03	Yes	Yes	0	8	9
104	R:R:F113	R:R:I117	11.2377	8.79	Yes	Yes	1	8	8
105	R:R:I251	R:R:Y247	17.3778	6.04	Yes	Yes	0	6	7
106	R:R:I251	R:R:T195	16.829	3.04	Yes	Yes	1	6	5
107	R:R:L201	R:R:L205	12.8645	1.38	No	No	0	4	3
108	R:R:F114	R:R:T195	15.1796	3.89	Yes	Yes	1	7	5
109	R:R:F110	R:R:T106	28.359	3.89	Yes	Yes	1	5	4
110	R:R:F118	R:R:I117	22.0566	6.28	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T106	3.15	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F110	9.12	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T168	3.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R191	16.89	1	Yes	No	0	5	0	1
L:L:H2	R:R:W87	9.52	1	Yes	Yes	0	6	0	1
L:L:H2	R:R:F109	20.36	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:E279	8.62	1	Yes	Yes	0	5	0	1
L:L:H3	R:R:N192	3.83	1	Yes	Yes	0	5	0	1
L:L:H3	R:R:R272	4.51	1	Yes	No	0	4	0	1
L:L:G4	R:R:E279	6.55	0	No	Yes	0	5	0	1
L:L:V5	R:R:W87	8.58	1	No	Yes	0	6	0	1
L:L:V5	R:R:L91	7.45	1	No	No	0	5	0	1
L:L:K7	R:R:E94	2.7	1	No	No	0	4	0	1
L:L:K7	R:R:N173	8.39	1	No	Yes	0	3	0	1
L:L:S13	R:R:R268	5.27	0	No	No	0	4	0	1
L:L:K14	R:R:R268	6.19	0	No	No	0	4	0	1
L:L:Q31	R:R:K171	2.71	0	No	Yes	0	3	0	1
L:L:A32	R:R:K171	3.21	0	No	Yes	0	3	0	1
L:L:C35	R:R:C176	7.28	0	No	Yes	0	3	0	1
L:L:R47	R:R:Y22	4.12	0	No	No	0	2	0	1
L:L:L48	R:R:Y22	5.86	0	No	No	0	2	0	1
R:R:L91	R:R:T31	5.9	0	No	No	5	5	1	2
R:R:F109	R:R:F80	6.43	0	Yes	No	7	7	1	2
R:R:T105	R:R:T83	4.71	0	No	No	5	7	2	2
R:R:F109	R:R:T83	3.89	0	Yes	No	7	7	1	2
R:R:L84	R:R:W87	3.42	1	Yes	Yes	7	6	2	1
R:R:C102	R:R:W87	2.61	1	Yes	Yes	9	6	2	1
R:R:T105	R:R:W87	12.13	0	No	Yes	5	6	2	1
R:R:T106	R:R:W87	8.49	1	Yes	Yes	4	6	1	1
R:R:C175	R:R:W87	5.22	1	Yes	Yes	9	6	2	1
R:R:C102	R:R:Y90	6.72	1	Yes	Yes	9	5	2	2
R:R:N173	R:R:Y90	3.49	1	Yes	Yes	3	5	1	2
R:R:E94	R:R:N173	3.94	1	No	Yes	4	3	1	1
R:R:C102	R:R:C175	7.28	1	Yes	Yes	9	9	2	2
R:R:K103	R:R:T168	3	0	No	Yes	7	5	2	1
R:R:F110	R:R:T106	3.89	1	Yes	Yes	5	4	1	1
R:R:T106	R:R:T168	3.14	1	Yes	Yes	4	5	1	1
R:R:C175	R:R:T106	5.07	1	Yes	Yes	9	4	2	1
R:R:F109	R:R:F110	5.36	0	Yes	Yes	7	5	1	1
R:R:F110	R:R:Q164	23.42	1	Yes	Yes	5	4	1	2
R:R:F110	R:R:R191	3.21	1	Yes	No	5	5	1	1
R:R:Q164	R:R:R191	10.51	1	Yes	No	4	5	2	1
R:R:C175	R:R:T168	3.38	1	Yes	Yes	9	5	2	1
R:R:E172	R:R:K171	6.75	0	No	Yes	1	3	2	1
R:R:E174	R:R:K171	4.05	1	No	Yes	1	3	2	1
R:R:C176	R:R:K171	4.85	1	Yes	Yes	3	3	1	1
R:R:E174	R:R:N173	2.63	1	No	Yes	1	3	2	1
R:R:C176	R:R:E174	4.56	1	Yes	No	3	1	1	2
R:R:C176	R:R:G177	3.92	1	Yes	No	3	4	1	2
R:R:I251	R:R:N192	5.66	1	Yes	Yes	6	5	2	1
R:R:E254	R:R:N192	13.15	1	No	Yes	4	5	2	1
R:R:N192	R:R:T255	8.77	1	Yes	No	5	5	1	2
R:R:I251	R:R:Y247	6.04	1	Yes	Yes	6	7	2	2
R:R:E279	R:R:Y247	7.86	0	Yes	Yes	5	7	1	2
R:R:E254	R:R:I251	6.83	1	No	Yes	4	6	2	2
R:R:E254	R:R:T255	5.64	1	No	No	4	5	2	2
R:R:K257	R:R:R268	11.14	4	Yes	No	3	4	2	1
R:R:L275	R:R:R272	9.72	0	No	No	5	4	2	1
R:R:E279	R:R:L275	5.3	0	Yes	No	5	5	1	2
R:R:I23	R:R:R272	2.51	0	No	No	5	4	2	1
R:R:N192	R:R:P188	1.63	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XBX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	327
Number of Links	382
Number of Hubs	53
Number of Links mediated by Hubs	180
Number of Communities	11
Number of Nodes involved in Communities	87
Number of Links involved in Communities	121

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	80612
Length Of Smallest Path	3
Average Path Length	16.9464
Length of Longest Path	42
Minimum Path Strength	1.31
Average Path Strength	6.43398
Maximum Path Strength	18.15
Minimum Path Correlation	0.7
Average Path Correlation	0.946713
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	57.2482
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3916
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • CX3C chemokine receptor binding • signaling receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • G protein-coupled chemoattractant receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • C-X3-C chemokine receptor activity • C-C chemokine receptor activity • C-X3-C chemokine binding • CCR chemokine receptor binding • molecular function activator activity • signaling receptor activator activity • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • CXCR1 chemokine receptor binding • interleukin-8 receptor binding • CXCR chemokine receptor binding • cell adhesion molecule binding • protein-containing complex binding • integrin binding • chemoattractant activity • leukocyte tethering or rolling • leukocyte cell-cell adhesion • leukocyte migration • cell adhesion • cell-cell adhesion • immune system process • leukocyte adhesion to vascular endothelial cell • cellular extravasation • cell migration • cell motility • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of multicellular organismal development • regulation of developmental process • cellular developmental process • cell development • regulation of neurogenesis • regulation of cell differentiation • regulation of cell development • regulation of nervous system development • neurogenesis • cell differentiation • regulation of multicellular organismal process • immune response • adaptive immune response • response to stress • response to ischemia • biological process involved in interspecies interaction between organisms • response to other organism • defense response • defense response to symbiont • response to external stimulus • response to biotic stimulus • defense response to other organism • innate immune response • response to external biotic stimulus • cell-cell signaling • autocrine signaling • chemotaxis • taxis • locomotion • antifungal innate immune response • defense response to fungus • response to fungus • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cell chemotaxis • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • regulation of response to external stimulus • positive regulation of biological process • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • positive regulation of cellular process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • regulation of response to stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • response to wounding • phospholipase C-activating G protein-coupled receptor signaling pathway • developmental maturation • synapse maturation • cellular component organization • cell junction organization • synapse organization • cellular component organization or biogenesis • multicellular organismal-level homeostasis • homeostatic process • host-mediated modulation of intestinal microbiota composition • homeostasis of number of cells • modulation of process of another organism • host-mediated perturbation of symbiont process • cellular defense response • positive regulation of nervous system development • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of cell development • positive regulation of multicellular organismal process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • macrophage activation involved in immune response • cell activation • cell activation involved in immune response • myeloid leukocyte activation • myeloid cell activation involved in immune response • leukocyte activation • immune effector process • macrophage activation • microglial cell activation involved in immune response • leukocyte activation involved in inflammatory response • leukocyte activation involved in immune response • microglial cell activation • inflammatory response • glial cell activation • neuroinflammatory response • interleukin-1 production • negative regulation of biological process • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • regulation of tumor necrosis factor production • tumor necrosis factor superfamily cytokine production • tumor necrosis factor production • regulation of tumor necrosis factor superfamily cytokine production • microglial cell mediated cytotoxicity • regulation of immune effector process • regulation of myeloid leukocyte mediated immunity • myeloid leukocyte mediated immunity • negative regulation of microglial cell mediated cytotoxicity • negative regulation of leukocyte mediated cytotoxicity • leukocyte mediated immunity • negative regulation of cell killing • negative regulation of myeloid leukocyte mediated immunity • negative regulation of immune effector process • regulation of leukocyte mediated cytotoxicity • leukocyte mediated cytotoxicity • regulation of leukocyte mediated immunity • negative regulation of immune system process • regulation of cell killing • negative regulation of leukocyte mediated immunity • regulation of microglial cell mediated cytotoxicity • cell killing • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • cellular component disassembly • cell junction disassembly • synapse pruning • regulation of nitric oxide biosynthetic process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • regulation of nitric oxide metabolic process • negative regulation of signaling • regulation of programmed cell death • negative regulation of cell communication • negative regulation of apoptotic signaling pathway • negative regulation of response to stimulus • negative regulation of programmed cell death • regulation of apoptotic process • cell death • negative regulation of signal transduction • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • regulation of microglial cell migration • glial cell migration • macrophage migration • regulation of glial cell migration • regulation of macrophage migration • gliogenesis • microglial cell migration • regulation of synaptic plasticity • behavior • biological process involved in intraspecies interaction between organisms • social behavior • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • vasculature development • circulatory system development • negative regulation of vasculature development • anatomical structure morphogenesis • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • neuron apoptotic process • negative regulation of neuron apoptotic process • hippocampal neuron apoptotic process • regulation of hippocampal neuron apoptotic process • negative regulation of hippocampal neuron apoptotic process • regulation of neuron apoptotic process • central nervous system maturation • anatomical structure maturation • multiple spine synapse organization • multiple spine synapse organization, single dendrite • neuroblast proliferation • positive regulation of cell population proliferation • regulation of neuroblast proliferation • regulation of neural precursor cell proliferation • generation of neurons • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • positive regulation of neuroblast proliferation • neural precursor cell proliferation • cell surface receptor signaling pathway • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • negative regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor superfamily cytokine production • regulation of defense response • regulation of inflammatory response • positive regulation of inflammatory response • regulation of response to stress • positive regulation of defense response • positive regulation of microglial cell migration • positive regulation of macrophage migration • positive regulation of glial cell migration • cellular component biogenesis • cellular component assembly • protein-containing complex organization • protein-containing complex assembly • integrin activation • interleukin-6 production • regulation of interleukin-6 production • negative regulation of interleukin-6 production • neuron differentiation • neuron remodeling • neuron development • neuron maturation • cell maturation • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • positive regulation of cell-matrix adhesion • cell-matrix adhesion • positive regulation of cell-substrate adhesion • regulation of cell-matrix adhesion • neutrophil chemotaxis • neutrophil migration • granulocyte migration • granulocyte chemotaxis • positive chemotaxis • leukocyte migration involved in inflammatory response • regulation of neuron projection development • regulation of cellular component organization • positive regulation of cellular component organization • cell projection organization • neuron projection development • positive regulation of neuron projection development • positive regulation of cell projection organization • plasma membrane bounded cell projection organization • regulation of cell projection organization • regulation of plasma membrane bounded cell projection organization • signal transduction in absence of ligand • extrinsic apoptotic signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of locomotion • negative regulation of cell motility • negative regulation of cell migration • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • eosinophil chemotaxis • eosinophil migration • lymphocyte chemotaxis • lymphocyte migration • wound healing • angiogenesis involved in wound healing • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • cellular homeostasis • neuron cellular homeostasis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of signal transduction in absence of ligand • negative regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of macrophage activation • negative regulation of inflammatory response • regulation of leukocyte activation • regulation of cell activation • regulation of neuroinflammatory response • negative regulation of microglial cell activation • negative regulation of cell activation • negative regulation of response to external stimulus • negative regulation of defense response • regulation of microglial cell activation • negative regulation of neuroinflammatory response • negative regulation of leukocyte activation • negative regulation of macrophage activation • regulation of transforming growth factor beta production • transforming growth factor beta1 production • regulation of transforming growth factor beta1 production • positive regulation of transforming growth factor beta1 production • transforming growth factor beta production • positive regulation of gene expression • positive regulation of transforming growth factor beta production • positive regulation of cytokine production • response to chemokine • cellular response to chemokine • chemokine-mediated signaling pathway • regulation of lipopolysaccharide-mediated signaling pathway • regulation of response to biotic stimulus • lipopolysaccharide-mediated signaling pathway • negative regulation of interleukin-1 alpha production • regulation of interleukin-1 alpha production • interleukin-1 alpha production • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of actin filament-based process • regulation of actin filament bundle assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • regulation of actin filament organization • actin cytoskeleton organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • positive regulation of supramolecular fiber organization • regulation of cellular component biogenesis • regulation of organelle organization • organelle organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • leukocyte adhesive activation • positive regulation of angiogenesis • positive regulation of vasculature development • humoral immune response • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of calcium-independent cell-cell adhesion • positive regulation of cell-cell adhesion • calcium-independent cell-cell adhesion • regulation of cell-cell adhesion • positive regulation of calcium-independent cell-cell adhesion • negative regulation of cell adhesion • negative regulation of cell-substrate adhesion • macrophage chemotaxis • microglial cell proliferation • leukocyte proliferation • macrophage proliferation • glial cell proliferation • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of neuron migration • regulation of neuron migration • neuron migration • glutamate receptor signaling pathway • negative regulation of glutamate receptor signaling pathway • regulation of glutamate receptor signaling pathway • cell surface • external side of plasma membrane • neuron projection • perinuclear region of cytoplasm • somatodendritic compartment • neuronal cell body membrane • cell body • cell body membrane • neuronal cell body • dendritic tree • endosome membrane • macropinosome membrane • endosome • intracellular vesicle • macropinosome • cytoplasmic vesicle membrane • cytoplasmic vesicle • vesicle membrane • pinosome • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49238
Sequence	>7XBX_nogp_Chain_R Y I G D I V V F G T V F L S I F Y S V I F A I G L V G N L L V V F A L T N S K K P K S V T D I Y L L N L A L S D L L F V A T L P F W T H Y L I N E K G L H N A M C K F T T A F F F I G F F G S I F F L T V I S I D R Y L A I V L A A N S M N N R T V Q H G V T I S L G V W A A A I L V A A P Q F M F T K Q K E N E C C G D Y P E V L Q E I W P V L R N V E T N F L G F L L P L L I M S Y C Y F R I I Q T L F S S K N H K K A K A I K L I L L V V I V F F L F W T P Y N V V I F L E T L K L Y D F F P S C D M R K D L R L A L S V T E T V A F S H C C L N P L I Y A F A G E K F R R Y L Y H L Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XBW	A	Protein	Chemokine	CX3CR1	Homo sapiens	-	-	Gi1/β1/γ2	2.8	2022-07-13	doi.org/10.1126/sciadv.abn8048
	7XBW (No Gprot)	A	Protein	Chemokine	CX3CR1	Homo sapiens	-	-		2.8	2022-07-13	doi.org/10.1126/sciadv.abn8048
	7XBX	A	Protein	Chemokine	CX3CR1	Homo sapiens	CX3CL1	-	Gi1/β1/γ2	3.4	2022-07-13	doi.org/10.1126/sciadv.abn8048
	7XBX (No Gprot)	A	Protein	Chemokine	CX3CR1	Homo sapiens	CX3CL1	-		3.4	2022-07-13	doi.org/10.1126/sciadv.abn8048

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