psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D266	R:R:I23	4.2	No	No	0	2	5
2	R:R:D266	R:R:G24	5.03	No	No	0	2	3
3	R:R:D25	R:R:D270	6.65	No	No	0	4	2
4	R:R:I26	R:R:V28	3.07	No	No	0	5	4
5	R:R:L273	R:R:V27	8.94	No	No	0	1	2
6	R:R:L91	R:R:T31	2.95	No	No	0	5	5
7	R:R:L34	R:R:Y38	7.03	No	Yes	0	5	7
8	R:R:L34	R:R:L91	4.15	No	No	0	5	5
9	R:R:I92	R:R:S35	9.29	No	No	0	4	5
10	R:R:I36	R:R:S39	3.1	No	No	0	6	5
11	R:R:F37	R:R:I41	10.05	No	No	0	5	7
12	R:R:T280	R:R:Y38	4.99	No	Yes	0	5	7
13	R:R:F283	R:R:Y38	3.09	No	Yes	0	6	7
14	R:R:I41	R:R:V40	3.07	No	No	0	7	5
15	R:R:I44	R:R:V40	3.07	No	No	0	5	5
16	R:R:C287	R:R:I41	9.82	No	No	0	8	7
17	R:R:F42	R:R:L84	7.31	No	Yes	6	7	7
18	R:R:F42	R:R:P85	5.78	No	No	6	7	8
19	R:R:C287	R:R:I44	3.27	No	No	0	8	5
20	R:R:I44	R:R:L291	4.28	No	No	0	5	6
21	R:R:G48	R:R:V47	3.68	No	No	0	8	4
22	R:R:L51	R:R:V47	2.98	No	No	0	6	4
23	R:R:G48	R:R:P290	4.06	No	No	0	8	9
24	R:R:D77	R:R:N49	8.08	No	No	0	9	9
25	R:R:L78	R:R:N49	9.61	No	No	0	7	9
26	R:R:F54	R:R:L50	7.31	No	No	0	4	4
27	R:R:L304	R:R:L51	5.54	No	No	0	7	6
28	R:R:L56	R:R:V52	2.98	No	No	0	7	8
29	R:R:A74	R:R:V52	3.39	No	No	0	9	8
30	R:R:F54	R:R:Y303	4.13	No	Yes	0	4	4
31	R:R:A55	R:R:Y303	5.34	No	Yes	0	7	4
32	R:R:D67	R:R:L56	5.43	No	No	0	8	7
33	R:R:K63	R:R:T57	4.5	No	No	0	6	3
34	R:R:N58	R:R:S59	4.47	No	No	0	5	5
35	R:R:N58	R:R:Y303	11.63	No	Yes	0	5	4
36	R:R:K61	R:R:P62	3.35	No	No	0	5	6
37	R:R:D67	R:R:S64	10.31	No	No	0	8	8
38	R:R:I68	R:R:V65	3.07	No	No	0	6	6
39	R:R:V65	R:R:Y69	6.31	No	Yes	2	6	7
40	R:R:D126	R:R:V65	2.92	No	No	2	8	6
41	R:R:R127	R:R:T66	5.17	No	No	0	9	8
42	R:R:V122	R:R:Y69	7.57	No	Yes	0	7	7
43	R:R:I123	R:R:Y69	4.84	No	Yes	0	9	7
44	R:R:D126	R:R:Y69	5.75	No	Yes	2	8	7
45	R:R:I149	R:R:Y69	7.25	Yes	Yes	0	5	7
46	R:R:L70	R:R:Y293	7.03	No	No	0	8	9
47	R:R:F119	R:R:N72	18.12	Yes	No	2	8	9
48	R:R:N72	R:R:S150	8.94	No	No	2	9	8
49	R:R:N72	R:R:W154	7.91	No	No	2	9	9
50	R:R:L73	R:R:S116	3	No	No	0	9	9
51	R:R:L120	R:R:L73	4.15	No	No	0	9	9
52	R:R:L73	R:R:N289	4.12	No	No	0	9	9
53	R:R:S76	R:R:W154	4.94	No	No	0	8	9
54	R:R:C286	R:R:D77	6.22	No	No	0	8	9
55	R:R:D77	R:R:N289	10.77	No	No	0	9	9
56	R:R:F108	R:R:L79	6.09	No	No	0	5	7
57	R:R:I111	R:R:L79	2.85	No	No	0	5	7
58	R:R:F109	R:R:F80	3.22	Yes	No	0	7	7
59	R:R:F80	R:R:G112	4.52	No	No	0	7	8
60	R:R:C286	R:R:F80	8.38	No	No	0	8	7
61	R:R:L84	R:R:V81	2.98	Yes	No	0	7	6
62	R:R:T105	R:R:T83	4.71	No	No	0	5	7
63	R:R:F108	R:R:T83	3.89	No	No	0	5	7
64	R:R:L84	R:R:P85	6.57	Yes	No	6	7	8
65	R:R:F283	R:R:L84	9.74	No	Yes	0	6	7
66	R:R:F86	R:R:W87	27.06	Yes	No	3	7	6
67	R:R:F86	R:R:Y90	20.63	Yes	Yes	3	7	5
68	R:R:F86	R:R:M101	6.22	Yes	No	3	7	6
69	R:R:F86	R:R:T105	27.24	Yes	No	3	7	5
70	R:R:T105	R:R:W87	3.64	No	No	3	5	6
71	R:R:H89	R:R:N93	17.86	No	No	0	4	3
72	R:R:L97	R:R:Y90	15.24	No	Yes	0	7	5
73	R:R:M101	R:R:Y90	8.38	No	Yes	3	6	5
74	R:R:C102	R:R:Y90	4.03	Yes	Yes	0	9	5
75	R:R:I92	R:R:N93	4.25	No	No	0	4	3
76	R:R:G96	R:R:K95	3.49	No	No	0	3	8
77	R:R:G96	R:R:H98	3.18	No	No	0	3	7
78	R:R:L97	R:R:Q170	17.3	No	No	0	7	5
79	R:R:K169	R:R:N99	9.79	No	No	0	4	2
80	R:R:N99	R:R:Q170	5.28	No	No	0	2	5
81	R:R:C102	R:R:C175	7.28	Yes	No	0	9	9
82	R:R:F165	R:R:K103	3.72	No	No	0	5	7
83	R:R:K103	R:R:T168	3	No	No	0	7	5
84	R:R:F104	R:R:F108	12.86	No	No	0	4	5
85	R:R:A107	R:R:F165	9.71	No	No	0	5	5
86	R:R:F109	R:R:F110	6.43	Yes	No	0	7	5
87	R:R:F109	R:R:W244	3.01	Yes	Yes	0	7	9
88	R:R:E279	R:R:F109	12.83	No	Yes	0	5	7
89	R:R:F110	R:R:Q164	14.05	No	No	0	5	4
90	R:R:F110	R:R:Y247	4.13	No	Yes	0	5	7
91	R:R:A161	R:R:I111	3.25	No	No	0	7	5
92	R:R:F113	R:R:F114	4.29	No	Yes	0	8	7
93	R:R:F113	R:R:W244	19.04	No	Yes	0	8	9
94	R:R:F114	R:R:F118	3.22	Yes	No	0	7	6
95	R:R:F114	R:R:V160	10.49	Yes	No	0	7	5
96	R:R:A161	R:R:F114	4.16	No	Yes	0	7	7
97	R:R:F114	R:R:T195	3.89	Yes	No	0	7	5
98	R:R:F114	R:R:L198	3.65	Yes	No	0	7	5
99	R:R:F240	R:R:S116	5.28	Yes	No	0	9	9
100	R:R:I117	R:R:T121	3.04	No	Yes	1	8	7
101	R:R:I117	R:R:P203	6.77	No	No	1	8	9
102	R:R:F240	R:R:I117	6.28	Yes	No	1	9	8
103	R:R:F119	R:R:S150	5.28	Yes	No	2	8	8
104	R:R:F119	R:R:V153	14.42	Yes	No	0	8	7
105	R:R:F119	R:R:W154	13.03	Yes	No	2	8	9
106	R:R:L120	R:R:V237	2.98	No	No	0	9	8
107	R:R:F240	R:R:L120	6.09	Yes	No	0	9	9
108	R:R:I125	R:R:T121	3.04	No	Yes	1	6	7
109	R:R:P203	R:R:T121	3.5	No	Yes	1	9	7
110	R:R:I206	R:R:T121	3.04	No	Yes	1	6	7
111	R:R:M207	R:R:T121	4.52	No	Yes	0	8	7
112	R:R:M207	R:R:S124	9.2	No	No	0	8	9
113	R:R:S124	R:R:Y211	11.45	No	Yes	0	9	9
114	R:R:I125	R:R:I206	2.94	No	No	1	6	6
115	R:R:A130	R:R:R127	4.15	No	No	0	8	9
116	R:R:I230	R:R:R127	3.76	No	No	0	5	9
117	R:R:V132	R:R:Y128	10.09	No	Yes	5	7	8
118	R:R:L133	R:R:Y128	3.52	No	Yes	0	6	8
119	R:R:Y128	R:R:Y209	8.94	Yes	No	5	8	5
120	R:R:C210	R:R:Y128	5.38	No	Yes	0	7	8
121	R:R:R213	R:R:Y128	5.14	Yes	Yes	5	4	8
122	R:R:L129	R:R:S137	4.5	No	No	0	5	6
123	R:R:I131	R:R:I214	7.36	No	Yes	4	8	8
124	R:R:I131	R:R:T217	3.04	No	No	0	8	5
125	R:R:I131	R:R:L218	2.85	No	Yes	4	8	8
126	R:R:R213	R:R:V132	3.92	Yes	No	5	4	7
127	R:R:T217	R:R:V132	6.35	No	No	0	5	7
128	R:R:L133	R:R:N136	8.24	No	No	0	6	4
129	R:R:H145	R:R:R141	12.41	No	No	0	3	6
130	R:R:G146	R:R:I149	5.29	No	Yes	0	7	5
131	R:R:E194	R:R:V160	2.85	No	No	0	4	5
132	R:R:Q164	R:R:R191	14.02	No	No	0	4	5
133	R:R:Q164	R:R:T195	7.09	No	No	0	4	5
134	R:R:F167	R:R:M166	9.95	No	No	0	5	4
135	R:R:F167	R:R:P180	4.33	No	No	0	5	5
136	R:R:F167	R:R:W187	7.02	No	Yes	0	5	4
137	R:R:D178	R:R:K169	16.59	No	No	0	4	4
138	R:R:C175	R:R:Q170	3.05	No	No	0	9	5
139	R:R:D178	R:R:K171	6.91	No	No	0	4	3
140	R:R:E174	R:R:R272	13.96	No	No	0	1	4
141	R:R:G177	R:R:Y179	8.69	No	Yes	0	4	5
142	R:R:Q184	R:R:Y179	4.51	No	Yes	0	3	5
143	R:R:W187	R:R:Y179	10.61	Yes	Yes	7	4	5
144	R:R:P188	R:R:Y179	8.34	No	Yes	7	4	5
145	R:R:R191	R:R:Y179	7.2	No	Yes	0	5	5
146	R:R:L183	R:R:P180	13.14	No	No	0	2	5
147	R:R:I186	R:R:V189	3.07	No	No	0	2	3
148	R:R:P188	R:R:W187	4.05	No	Yes	7	4	4
149	R:R:L258	R:R:V189	4.47	No	No	0	3	3
150	R:R:I251	R:R:N192	7.08	No	No	0	6	5
151	R:R:E254	R:R:N192	3.94	No	No	0	4	5
152	R:R:N192	R:R:T255	4.39	No	No	0	5	5
153	R:R:F197	R:R:V193	3.93	No	No	0	4	5
154	R:R:E194	R:R:L198	7.95	No	No	0	4	5
155	R:R:N196	R:R:N248	8.17	No	No	0	5	8
156	R:R:I251	R:R:N196	2.83	No	No	0	6	5
157	R:R:F252	R:R:N196	3.62	No	No	0	6	5
158	R:R:F197	R:R:L201	21.92	No	No	0	4	4
159	R:R:F200	R:R:F241	8.57	Yes	Yes	0	9	6
160	R:R:F200	R:R:W244	3.01	Yes	Yes	0	9	9
161	R:R:F200	R:R:N248	18.12	Yes	No	0	9	8
162	R:R:L204	R:R:S208	3	No	No	0	7	5
163	R:R:F241	R:R:L204	9.74	Yes	No	0	6	7
164	R:R:F241	R:R:M207	3.73	Yes	No	0	6	8
165	R:R:R213	R:R:Y209	11.32	Yes	No	5	4	5
166	R:R:I233	R:R:Y211	4.84	No	Yes	0	8	9
167	R:R:L234	R:R:Y211	5.86	No	Yes	0	4	9
168	R:R:V237	R:R:Y211	7.57	No	Yes	0	8	9
169	R:R:F212	R:R:Q216	17.57	No	No	0	3	3
170	R:R:Q216	R:R:R213	7.01	No	Yes	0	3	4
171	R:R:I214	R:R:L218	2.85	Yes	Yes	4	8	8
172	R:R:I214	R:R:I230	5.89	Yes	No	4	8	5
173	R:R:A227	R:R:L218	4.73	No	Yes	0	5	8
174	R:R:I230	R:R:L218	4.28	No	Yes	4	5	8
175	R:R:F219	R:R:H224	9.05	No	No	0	4	3
176	R:R:N223	R:R:S221	5.96	No	No	0	3	5
177	R:R:K225	R:R:K226	2.87	No	No	0	5	5
178	R:R:I233	R:R:L232	2.85	No	No	0	8	8
179	R:R:A296	R:R:L232	3.15	No	No	0	6	8
180	R:R:I238	R:R:L234	2.85	No	No	0	5	4
181	R:R:I292	R:R:L235	2.85	No	No	0	8	6
182	R:R:I292	R:R:V236	4.61	No	No	0	8	7
183	R:R:V236	R:R:Y293	6.31	No	No	0	7	9
184	R:R:F243	R:R:V239	5.24	No	No	0	8	7
185	R:R:I292	R:R:V239	4.61	No	No	0	8	7
186	R:R:F240	R:R:F241	4.29	Yes	Yes	0	9	6
187	R:R:F240	R:R:W244	11.02	Yes	Yes	1	9	9
188	R:R:F240	R:R:H285	10.18	Yes	No	1	9	9
189	R:R:F243	R:R:H285	7.92	No	No	0	8	9
190	R:R:F243	R:R:L288	8.53	No	No	0	8	7
191	R:R:W244	R:R:Y247	6.75	Yes	Yes	0	9	7
192	R:R:A282	R:R:W244	7.78	No	Yes	0	8	9
193	R:R:H285	R:R:W244	7.41	No	Yes	1	9	9
194	R:R:P246	R:R:T245	3.5	No	No	0	9	6
195	R:R:I251	R:R:Y247	8.46	No	Yes	0	6	7
196	R:R:T278	R:R:Y247	9.99	No	Yes	0	6	7
197	R:R:E279	R:R:Y247	3.37	No	Yes	0	5	7
198	R:R:A274	R:R:V250	3.39	No	No	0	6	5
199	R:R:T278	R:R:V250	4.76	No	No	0	6	5
200	R:R:F252	R:R:L256	13.4	No	No	0	6	5
201	R:R:F262	R:R:L253	3.65	Yes	No	8	1	5
202	R:R:L253	R:R:M267	8.48	No	Yes	8	5	1
203	R:R:E254	R:R:L271	11.93	No	No	0	4	5
204	R:R:E254	R:R:L275	5.3	No	No	0	4	5
205	R:R:F261	R:R:L256	4.87	No	No	0	1	5
206	R:R:K257	R:R:L258	4.23	No	No	0	3	3
207	R:R:K257	R:R:L271	2.82	No	No	0	3	5
208	R:R:F262	R:R:P263	5.78	Yes	No	0	1	3
209	R:R:F262	R:R:S264	5.28	Yes	No	0	1	5
210	R:R:F262	R:R:M267	9.95	Yes	Yes	8	1	1
211	R:R:D266	R:R:D270	6.65	No	No	0	2	2
212	R:R:D270	R:R:M267	9.7	No	Yes	0	2	1
213	R:R:L271	R:R:M267	7.07	No	Yes	0	5	1
214	R:R:R272	R:R:S276	5.27	No	No	0	4	5
215	R:R:L273	R:R:V277	2.98	No	No	0	1	5
216	R:R:E279	R:R:F283	3.5	No	No	0	5	6
217	R:R:N289	R:R:P290	3.26	No	No	0	9	9
218	R:R:F300	R:R:Y293	3.09	Yes	No	0	8	9
219	R:R:E298	R:R:K299	4.05	No	No	0	5	6
220	R:R:R301	R:R:Y305	6.17	No	No	0	8	3
221	R:R:L307	R:R:Y303	4.69	No	Yes	0	5	4
222	R:R:H306	R:R:K310	5.24	No	No	0	4	5
223	R:R:K226	R:R:N223	2.8	No	No	0	5	3
224	R:R:L46	R:R:L50	2.77	No	No	0	6	4
225	R:R:A55	R:R:F300	2.77	No	Yes	0	7	8
226	R:R:L56	R:R:L71	2.77	No	No	0	7	6
227	R:R:L71	R:R:L75	2.77	No	No	0	6	6
228	R:R:A157	R:R:F118	2.77	No	No	0	7	6
229	R:R:A296	R:R:F295	2.77	No	No	0	6	7
230	R:R:L218	R:R:N223	2.75	Yes	No	0	8	3
231	R:R:D25	R:R:L273	2.71	No	No	0	4	1
232	R:R:P163	R:R:W187	2.7	No	Yes	0	8	4
233	R:R:E174	R:R:L176	2.65	No	No	0	1	3
234	R:R:F33	R:R:V32	2.62	No	No	0	5	5
235	R:R:F300	R:R:V52	2.62	Yes	No	0	8	8
236	R:R:F165	R:R:T106	2.59	No	No	0	5	4
237	R:R:F200	R:R:T245	2.59	Yes	No	0	9	6
238	R:R:F219	R:R:I215	2.51	No	No	0	4	5
239	R:R:T88	R:R:Y38	2.5	No	Yes	0	6	7
240	R:R:K257	R:R:R268	2.48	No	No	0	3	4
241	R:R:F29	R:R:L34	2.44	No	No	0	7	5
242	R:R:I214	R:R:Y211	2.42	Yes	Yes	0	8	9
243	R:R:L129	R:R:Y128	2.34	No	Yes	0	5	8
244	R:R:F37	R:R:Y38	2.06	No	Yes	0	5	7
245	R:R:F119	R:R:Y69	2.06	Yes	Yes	2	8	7
246	R:R:C287	R:R:G45	1.96	No	No	0	8	8
247	R:R:A157	R:R:G115	1.95	No	No	0	7	7
248	R:R:A155	R:R:G152	1.95	No	No	0	5	4
249	R:R:A162	R:R:P163	1.87	No	No	0	4	8
250	R:R:G112	R:R:S76	1.86	No	No	0	8	8
251	R:R:G115	R:R:S76	1.86	No	No	0	7	8
252	R:R:G152	R:R:L151	1.71	No	No	0	4	4
253	R:R:G177	R:R:L176	1.71	No	No	0	4	3
254	R:R:G297	R:R:L232	1.71	No	No	0	8	8
255	R:R:A74	R:R:V53	1.7	No	No	0	9	7
256	R:R:G199	R:R:N248	1.7	No	No	0	6	8
257	R:R:C102	R:R:T106	1.69	Yes	No	0	9	4
258	R:R:C102	R:R:T168	1.69	Yes	No	0	9	5
259	R:R:L202	R:R:P203	1.64	No	No	0	5	9
260	R:R:E298	R:R:G297	1.64	No	No	0	5	8
261	R:R:S39	R:R:V40	1.62	No	No	0	5	5
262	R:R:S137	R:R:V143	1.62	No	No	0	6	4
263	R:R:S284	R:R:V281	1.62	No	No	0	5	7
264	R:R:T57	R:R:V53	1.59	No	No	0	3	7
265	R:R:T255	R:R:V193	1.59	No	No	0	5	5
266	R:R:T245	R:R:V249	1.59	No	No	0	6	6
267	R:R:T280	R:R:V281	1.59	No	No	0	5	7
268	R:R:K61	R:R:S59	1.53	No	No	0	5	5
269	R:R:I149	R:R:T142	1.52	Yes	No	0	5	6
270	R:R:I149	R:R:T148	1.52	Yes	No	0	5	3
271	R:R:F33	R:R:G30	1.51	No	No	0	5	4
272	R:R:L151	R:R:V147	1.49	No	No	0	4	4
273	R:R:N140	R:R:V143	1.48	No	No	0	4	4
274	R:R:I238	R:R:L242	1.43	No	No	0	5	5
275	R:R:A156	R:R:F118	1.39	No	No	0	4	6
276	R:R:A294	R:R:F300	1.39	No	Yes	0	7	8
277	R:R:H89	R:R:T88	1.37	No	No	0	4	6
278	R:R:H145	R:R:T148	1.37	No	No	0	3	3
279	R:R:N139	R:R:N140	1.36	No	No	0	4	4
280	R:R:E94	R:R:N173	1.31	No	No	0	4	3
281	R:R:H224	R:R:K225	1.31	No	No	0	3	5
282	R:R:L304	R:R:Y308	1.17	No	No	0	7	7
283	R:R:D260	R:R:Y259	1.15	No	No	0	1	2
284	R:R:F295	R:R:R301	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y38	3.934	5	0	7
2	R:R:Y69	5.63	6	2	7
3	R:R:L84	6.65	4	6	7
4	R:R:F86	20.2875	4	3	7
5	R:R:Y90	12.07	4	3	5
6	R:R:C102	3.6725	4	0	9
7	R:R:F109	6.3725	4	0	7
8	R:R:F114	4.95	6	0	7
9	R:R:F119	10.582	5	2	8
10	R:R:T121	3.428	5	1	7
11	R:R:Y128	5.90167	6	5	8
12	R:R:I149	3.895	4	0	5
13	R:R:Y179	7.87	5	7	5
14	R:R:W187	6.095	4	7	4
15	R:R:F200	8.0725	4	0	9
16	R:R:Y211	6.428	5	0	9
17	R:R:R213	6.8475	4	5	4
18	R:R:I214	4.63	4	4	8
19	R:R:L218	3.492	5	4	8
20	R:R:F240	7.19	6	1	9
21	R:R:F241	6.5825	4	0	6
22	R:R:W244	8.28857	7	1	9
23	R:R:Y247	6.54	5	0	7
24	R:R:F262	6.165	4	8	1
25	R:R:M267	8.8	4	8	1
26	R:R:F300	2.4675	4	0	8
27	R:R:Y303	6.4475	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D25	R:R:D270	10.1069	6.65	No	No	0	4	2
2	R:R:D270	R:R:M267	19.9083	9.7	No	Yes	0	2	1
3	R:R:L271	R:R:M267	32.2103	7.07	No	Yes	0	5	1
4	R:R:E254	R:R:L271	46.1687	11.93	No	No	0	4	5
5	R:R:E254	R:R:N192	50.6151	3.94	No	No	0	4	5
6	R:R:I251	R:R:N192	61.912	7.08	No	No	0	6	5
7	R:R:I251	R:R:Y247	68.9314	8.46	No	Yes	0	6	7
8	R:R:E279	R:R:Y247	54.0645	3.37	No	Yes	0	5	7
9	R:R:E279	R:R:F283	89.7564	3.5	No	No	0	5	6
10	R:R:F283	R:R:Y38	75.1628	3.09	No	Yes	0	6	7
11	R:R:L34	R:R:Y38	12.8648	7.03	No	Yes	0	5	7
12	R:R:T88	R:R:Y38	16.5152	2.5	No	Yes	0	6	7
13	R:R:H89	R:R:T88	13.2427	1.37	No	No	0	4	6
14	R:R:F37	R:R:Y38	35.6999	2.06	No	Yes	0	5	7
15	R:R:F37	R:R:I41	32.5239	10.05	No	No	0	5	7
16	R:R:I41	R:R:V40	16.2901	3.07	No	No	0	7	5
17	R:R:C287	R:R:I41	13.1302	9.82	No	No	0	8	7
18	R:R:F283	R:R:L84	13.2427	9.74	No	Yes	0	6	7
19	R:R:W244	R:R:Y247	95.248	6.75	Yes	Yes	0	9	7
20	R:R:F240	R:R:W244	100	11.02	Yes	Yes	1	9	9
21	R:R:F240	R:R:S116	12.6075	5.28	Yes	No	0	9	9
22	R:R:L73	R:R:S116	10.6617	3	No	No	0	9	9
23	R:R:L73	R:R:N289	21.1707	4.12	No	No	0	9	9
24	R:R:N289	R:R:P290	18.5656	3.26	No	No	0	9	9
25	R:R:G48	R:R:P290	15.4619	4.06	No	No	0	8	9
26	R:R:F240	R:R:L120	91.3484	6.09	Yes	No	0	9	9
27	R:R:L120	R:R:L73	15.0599	4.15	No	No	0	9	9
28	R:R:G48	R:R:V47	12.3422	3.68	No	No	0	8	4
29	R:R:F110	R:R:Y247	32.2023	4.13	No	Yes	0	5	7
30	R:R:F109	R:R:F110	31.4384	6.43	Yes	No	0	7	5
31	R:R:F109	R:R:F80	56.4686	3.22	Yes	No	0	7	7
32	R:R:C286	R:R:F80	12.5432	8.38	No	No	0	8	7
33	R:R:C286	R:R:D77	10.8306	6.22	No	No	0	8	9
34	R:R:F109	R:R:W244	78.3629	3.01	Yes	Yes	0	7	9
35	R:R:E279	R:R:F109	53.5177	12.83	No	Yes	0	5	7
36	R:R:H285	R:R:W244	50.2694	7.41	No	Yes	1	9	9
37	R:R:F243	R:R:H285	68.1756	7.92	No	No	0	8	9
38	R:R:F243	R:R:V239	64.0106	5.24	No	No	0	8	7
39	R:R:I292	R:R:V239	61.896	4.61	No	No	0	8	7
40	R:R:I292	R:R:V236	57.8274	4.61	No	No	0	8	7
41	R:R:V236	R:R:Y293	55.6324	6.31	No	No	0	7	9
42	R:R:F300	R:R:Y293	51.2181	3.09	Yes	No	0	8	9
43	R:R:A55	R:R:F300	24.6764	2.77	No	Yes	0	7	8
44	R:R:A55	R:R:Y303	22.2642	5.34	No	Yes	0	7	4
45	R:R:F300	R:R:V52	23.9447	2.62	Yes	No	0	8	8
46	R:R:L56	R:R:V52	12.294	2.98	No	No	0	7	8
47	R:R:N58	R:R:Y303	10.0426	11.63	No	Yes	0	5	4
48	R:R:F80	R:R:G112	46.1526	4.52	No	No	0	7	8
49	R:R:G112	R:R:S76	44.1184	1.86	No	No	0	8	8
50	R:R:S76	R:R:W154	44.2792	4.94	No	No	0	8	9
51	R:R:F119	R:R:W154	36.8738	13.03	Yes	No	2	8	9
52	R:R:F119	R:R:Y69	29.7097	2.06	Yes	Yes	2	8	7
53	R:R:L120	R:R:V237	84.2165	2.98	No	No	0	9	8
54	R:R:V237	R:R:Y211	82.4234	7.57	No	Yes	0	8	9
55	R:R:I214	R:R:Y211	66.5675	2.42	Yes	Yes	0	8	9
56	R:R:I149	R:R:Y69	14.9715	7.25	Yes	Yes	0	5	7
57	R:R:F113	R:R:W244	61.2849	19.04	No	Yes	0	8	9
58	R:R:F113	R:R:F114	59.8697	4.29	No	Yes	0	8	7
59	R:R:A161	R:R:F114	52.4162	4.16	No	Yes	0	7	7
60	R:R:A161	R:R:I111	50.398	3.25	No	No	0	7	5
61	R:R:I111	R:R:L79	48.3638	2.85	No	No	0	5	7
62	R:R:F108	R:R:L79	46.3134	6.09	No	No	0	5	7
63	R:R:F108	R:R:T83	42.1645	3.89	No	No	0	5	7
64	R:R:T105	R:R:T83	40.0659	4.71	No	No	0	5	7
65	R:R:F86	R:R:T105	35.9331	27.24	Yes	No	3	7	5
66	R:R:F86	R:R:Y90	31.6395	20.63	Yes	Yes	3	7	5
67	R:R:L97	R:R:Y90	13.7895	15.24	No	Yes	0	7	5
68	R:R:C102	R:R:Y90	15.8559	4.03	Yes	Yes	0	9	5
69	R:R:L97	R:R:Q170	11.4979	17.3	No	No	0	7	5
70	R:R:F110	R:R:Q164	46.426	14.05	No	No	0	5	4
71	R:R:F114	R:R:F118	12.8488	3.22	Yes	No	0	7	6
72	R:R:F240	R:R:I117	12.5915	6.28	Yes	No	1	9	8
73	R:R:I251	R:R:N196	11.2567	2.83	No	No	0	6	5
74	R:R:F200	R:R:N248	13.09	18.12	Yes	No	0	9	8
75	R:R:F200	R:R:F241	14.6338	8.57	Yes	Yes	0	9	6
76	R:R:F241	R:R:M207	12.0527	3.73	Yes	No	0	6	8
77	R:R:F200	R:R:W244	22.5376	3.01	Yes	Yes	0	9	9
78	R:R:F240	R:R:F241	11.3452	4.29	Yes	Yes	0	9	6
79	R:R:M207	R:R:S124	10.71	9.2	No	No	0	8	9
80	R:R:I131	R:R:I214	37.3	7.36	No	Yes	4	8	8
81	R:R:I131	R:R:T217	37.1472	3.04	No	No	0	8	5
82	R:R:T217	R:R:V132	34.9441	6.35	No	No	0	5	7
83	R:R:V132	R:R:Y128	23.3658	10.09	No	Yes	5	7	8
84	R:R:L129	R:R:Y128	12.0125	2.34	No	Yes	0	5	8
85	R:R:I214	R:R:L218	19.6028	2.85	Yes	Yes	4	8	8
86	R:R:Q164	R:R:R191	47.1416	14.02	No	No	0	4	5
87	R:R:R191	R:R:Y179	44.5204	7.2	No	Yes	0	5	5
88	R:R:W187	R:R:Y179	21.5968	10.61	Yes	Yes	7	4	5
89	R:R:F167	R:R:W187	12.4869	7.02	No	Yes	0	5	4
90	R:R:G177	R:R:Y179	14.875	8.69	No	Yes	0	4	5
91	R:R:G177	R:R:L176	11.7874	1.71	No	No	0	4	3
92	R:R:K257	R:R:L271	12.8488	2.82	No	No	0	3	5
93	R:R:N192	R:R:T255	10.3803	4.39	No	No	0	5	5
94	R:R:F252	R:R:N196	10.8949	3.62	No	No	0	6	5
95	R:R:I233	R:R:Y211	20.6641	4.84	No	Yes	0	8	9
96	R:R:L218	R:R:N223	16.5394	2.75	Yes	No	0	8	3
97	R:R:K226	R:R:N223	11.8919	2.8	No	No	0	5	3
98	R:R:I233	R:R:L232	18.4208	2.85	No	No	0	8	8
99	R:R:F240	R:R:H285	19.9566	10.18	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7XBW_nogp

PDB Summary
PDB	7XBW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.82
Number of Linked Nodes	263
Number of Links	284
Number of Hubs	27
Number of Links mediated by Hubs	111
Number of Communities	8
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	42080
Length Of Smallest Path	3
Average Path Length	13.2521
Length of Longest Path	31
Minimum Path Strength	1.42
Average Path Strength	6.23595
Maximum Path Strength	23.935
Minimum Path Correlation	0.7
Average Path Correlation	0.922279
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.0061
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.9099
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • CX3C chemokine receptor binding • signaling receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • G protein-coupled chemoattractant receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • C-X3-C chemokine receptor activity • C-C chemokine receptor activity • C-X3-C chemokine binding • leukocyte tethering or rolling • leukocyte cell-cell adhesion • leukocyte migration • cell adhesion • cell-cell adhesion • immune system process • leukocyte adhesion to vascular endothelial cell • cellular extravasation • cell migration • cell motility • head development • central nervous system development • brain development • nervous system development • regulation of multicellular organismal development • regulation of developmental process • cellular developmental process • cell development • regulation of neurogenesis • regulation of cell differentiation • regulation of cell development • regulation of nervous system development • neurogenesis • cell differentiation • regulation of multicellular organismal process • immune response • adaptive immune response • response to stress • response to ischemia • biological process involved in interspecies interaction between organisms • response to other organism • defense response • defense response to symbiont • response to external stimulus • response to biotic stimulus • defense response to other organism • innate immune response • response to external biotic stimulus • autocrine signaling • chemotaxis • taxis • locomotion • antifungal innate immune response • defense response to fungus • response to fungus • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cell chemotaxis • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • regulation of response to external stimulus • positive regulation of biological process • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • positive regulation of cellular process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • regulation of response to stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • response to wounding • developmental maturation • synapse maturation • cellular component organization • cell junction organization • synapse organization • cellular component organization or biogenesis • multicellular organismal-level homeostasis • homeostatic process • host-mediated modulation of intestinal microbiota composition • homeostasis of number of cells • modulation of process of another organism • host-mediated perturbation of symbiont process • cellular defense response • positive regulation of nervous system development • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of cell development • positive regulation of multicellular organismal process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • macrophage activation involved in immune response • cell activation • cell activation involved in immune response • myeloid leukocyte activation • myeloid cell activation involved in immune response • leukocyte activation • immune effector process • macrophage activation • microglial cell activation involved in immune response • leukocyte activation involved in inflammatory response • leukocyte activation involved in immune response • microglial cell activation • inflammatory response • glial cell activation • neuroinflammatory response • interleukin-1 production • negative regulation of biological process • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • regulation of tumor necrosis factor production • tumor necrosis factor superfamily cytokine production • tumor necrosis factor production • regulation of tumor necrosis factor superfamily cytokine production • microglial cell mediated cytotoxicity • regulation of immune effector process • regulation of myeloid leukocyte mediated immunity • myeloid leukocyte mediated immunity • negative regulation of microglial cell mediated cytotoxicity • negative regulation of leukocyte mediated cytotoxicity • leukocyte mediated immunity • negative regulation of cell killing • negative regulation of myeloid leukocyte mediated immunity • negative regulation of immune effector process • regulation of leukocyte mediated cytotoxicity • leukocyte mediated cytotoxicity • regulation of leukocyte mediated immunity • negative regulation of immune system process • regulation of cell killing • negative regulation of leukocyte mediated immunity • regulation of microglial cell mediated cytotoxicity • cell killing • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • cellular component disassembly • cell junction disassembly • synapse pruning • regulation of nitric oxide biosynthetic process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • regulation of nitric oxide metabolic process • negative regulation of signaling • regulation of programmed cell death • negative regulation of cell communication • negative regulation of apoptotic signaling pathway • negative regulation of response to stimulus • negative regulation of programmed cell death • regulation of apoptotic process • cell death • negative regulation of signal transduction • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • regulation of microglial cell migration • glial cell migration • macrophage migration • regulation of glial cell migration • regulation of macrophage migration • gliogenesis • microglial cell migration • regulation of synaptic plasticity • behavior • biological process involved in intraspecies interaction between organisms • social behavior • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • vasculature development • circulatory system development • negative regulation of vasculature development • anatomical structure morphogenesis • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • neuron apoptotic process • negative regulation of neuron apoptotic process • hippocampal neuron apoptotic process • regulation of hippocampal neuron apoptotic process • negative regulation of hippocampal neuron apoptotic process • regulation of neuron apoptotic process • central nervous system maturation • anatomical structure maturation • multiple spine synapse organization • multiple spine synapse organization, single dendrite • neuroblast proliferation • positive regulation of cell population proliferation • regulation of neuroblast proliferation • regulation of neural precursor cell proliferation • generation of neurons • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • positive regulation of neuroblast proliferation • neural precursor cell proliferation • cell surface • external side of plasma membrane • perinuclear region of cytoplasm • somatodendritic compartment • neuronal cell body membrane • cell body • cell body membrane • neuronal cell body • dendritic tree • endosome membrane • macropinosome membrane • endosome • intracellular vesicle • macropinosome • cytoplasmic vesicle membrane • cytoplasmic vesicle • vesicle membrane • pinosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49238
Sequence	>7XBW_nogp_Chain_R I G D I V V F G T V F L S I F Y S V I F A I G L V G N L L V V F A L T N S K K P K S V T D I Y L L N L A L S D L L F V A T L P F W T H Y L I N E K G L H N A M C K F T T A F F F I G F F G S I F F L T V I S I D R Y L A I V L A A N S M N N R T V Q H G V T I S L G V W A A A I L V A A P Q F M F T K Q K E N E C L G D Y P E V L Q E I W P V L R N V E T N F L G F L L P L L I M S Y C Y F R I I Q T L F S S K N H K K A K A I K L I L L V V I V F F L F W T P Y N V V I F L E T L K L Y D F F P S C D M R K D L R L A L S V T E T V A F S H C C L N P L I Y A F A G E K F R R Y L Y H L Y G K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XBW	A	Protein	Chemokine	CX3CR1	Homo sapiens	-	-	Gi1/β1/γ2	2.8	2022-07-13	doi.org/10.1126/sciadv.abn8048
	7XBW (No Gprot)	A	Protein	Chemokine	CX3CR1	Homo sapiens	-	-		2.8	2022-07-13	doi.org/10.1126/sciadv.abn8048
	7XBX	A	Protein	Chemokine	CX3CR1	Homo sapiens	CX3CL1	-	Gi1/β1/γ2	3.4	2022-07-13	doi.org/10.1126/sciadv.abn8048
	7XBX (No Gprot)	A	Protein	Chemokine	CX3CR1	Homo sapiens	CX3CL1	-		3.4	2022-07-13	doi.org/10.1126/sciadv.abn8048

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