psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D134	15.17	Yes	No	0	0	8
2	L:L:?1	R:R:V135	22.7	Yes	No	0	0	6
3	L:L:?1	R:R:S138	9.15	Yes	No	0	0	6
4	L:L:?1	R:R:T139	2.99	Yes	Yes	0	0	7
5	L:L:?1	R:R:F214	8.66	Yes	No	0	0	7
6	L:L:?1	R:R:G218	3.48	Yes	No	0	0	7
7	L:L:?1	R:R:S219	12.2	Yes	No	0	0	7
8	L:L:?1	R:R:A222	4.8	Yes	No	0	0	7
9	L:L:?1	R:R:F327	4.95	Yes	No	0	0	7
10	R:R:I60	R:R:I63	4.42	No	No	0	7	7
11	R:R:I60	R:R:W355	10.57	No	Yes	0	7	7
12	R:R:I64	R:R:I68	4.42	Yes	No	0	7	6
13	R:R:I64	R:R:M107	5.83	Yes	No	0	7	8
14	R:R:I64	R:R:P108	3.39	Yes	No	0	7	9
15	R:R:N71	R:R:T67	4.39	Yes	Yes	2	9	7
16	R:R:D99	R:R:T67	4.34	Yes	Yes	2	9	7
17	R:R:M107	R:R:T67	3.01	No	Yes	0	8	7
18	R:R:S361	R:R:T67	3.2	No	Yes	2	9	7
19	R:R:G362	R:R:T67	5.46	No	Yes	0	7	7
20	R:R:A96	R:R:N71	3.13	No	Yes	0	9	9
21	R:R:D99	R:R:N71	16.16	Yes	Yes	2	9	9
22	R:R:M100	R:R:N71	4.21	No	Yes	0	7	9
23	R:R:N71	R:R:P365	4.89	Yes	No	2	9	9
24	R:R:F379	R:R:L73	7.31	No	No	0	7	7
25	R:R:A96	R:R:V74	3.39	No	No	0	9	9
26	R:R:M76	R:R:Y382	8.38	No	No	0	5	5
27	R:R:L84	R:R:V78	2.98	No	No	0	8	8
28	R:R:M93	R:R:V78	9.13	No	No	0	5	8
29	R:R:E81	R:R:M80	10.83	No	No	0	6	5
30	R:R:M80	R:R:Y382	8.38	No	No	0	5	5
31	R:R:A378	R:R:E81	4.53	No	No	0	7	6
32	R:R:L84	R:R:N89	9.61	No	No	0	8	9
33	R:R:A87	R:R:N86	3.13	No	No	0	5	7
34	R:R:N86	R:R:Y90	11.63	No	No	5	7	4
35	R:R:N86	R:R:R168	7.23	No	Yes	5	7	4
36	R:R:A87	R:R:K170	4.82	No	Yes	0	5	7
37	R:R:N89	R:R:T88	4.39	No	No	0	9	8
38	R:R:N89	R:R:Y375	6.98	No	No	0	9	8
39	R:R:R168	R:R:Y90	3.09	Yes	No	5	4	4
40	R:R:F91	R:R:H144	12.44	Yes	Yes	0	8	8
41	R:R:A147	R:R:F91	4.16	No	Yes	0	7	8
42	R:R:F91	R:R:I148	5.02	Yes	Yes	0	8	9
43	R:R:F91	R:R:K174	3.72	Yes	No	0	8	6
44	R:R:H144	R:R:S94	6.97	Yes	No	7	8	9
45	R:R:I175	R:R:S94	4.64	No	No	0	8	9
46	R:R:S94	R:R:W179	6.18	No	Yes	7	9	9
47	R:R:L95	R:R:S141	3	No	No	0	9	9
48	R:R:H144	R:R:L95	9	Yes	No	0	8	9
49	R:R:D99	R:R:S361	10.31	Yes	No	2	9	9
50	R:R:D99	R:R:P365	4.83	Yes	No	2	9	9
51	R:R:L104	R:R:M100	4.24	No	No	0	4	7
52	R:R:F137	R:R:L101	12.18	Yes	No	0	7	6
53	R:R:G103	R:R:V102	3.68	No	No	0	6	7
54	R:R:V102	R:R:V106	3.21	No	No	0	7	7
55	R:R:S361	R:R:V102	3.23	No	No	0	9	7
56	R:R:G103	R:R:M107	5.24	No	No	0	6	8
57	R:R:D134	R:R:V106	13.15	No	No	4	8	7
58	R:R:V106	R:R:Y358	5.05	No	Yes	4	7	8
59	R:R:L109	R:R:W130	10.25	No	No	0	5	5
60	R:R:S110	R:R:W130	3.71	No	No	0	7	5
61	R:R:S110	R:R:W355	4.94	No	Yes	0	7	7
62	R:R:L112	R:R:Y116	9.38	No	No	0	4	5
63	R:R:T206	R:R:Y118	3.75	No	No	0	4	4
64	R:R:F201	R:R:V119	6.55	No	Yes	0	4	3
65	R:R:T206	R:R:V119	4.76	No	Yes	0	4	3
66	R:R:C127	R:R:I131	3.27	No	No	1	9	5
67	R:R:C127	R:R:C207	7.28	No	No	1	9	9
68	R:R:S132	R:R:V129	3.23	Yes	No	0	6	4
69	R:R:C207	R:R:I131	3.27	No	No	1	9	5
70	R:R:S132	R:R:S186	4.89	Yes	No	1	6	8
71	R:R:I189	R:R:S132	12.39	Yes	Yes	1	6	6
72	R:R:P190	R:R:S132	3.56	No	Yes	1	7	6
73	R:R:F137	R:R:L133	3.65	Yes	No	0	7	5
74	R:R:D134	R:R:Y358	10.34	No	Yes	4	8	8
75	R:R:V135	R:R:V185	3.21	No	No	0	6	6
76	R:R:F137	R:R:L136	6.09	Yes	Yes	0	7	6
77	R:R:L136	R:R:S182	3	Yes	No	0	6	8
78	R:R:L136	R:R:S186	3	Yes	No	0	6	8
79	R:R:F137	R:R:W179	4.01	Yes	Yes	0	7	9
80	R:R:M143	R:R:T139	3.01	Yes	Yes	0	6	7
81	R:R:S182	R:R:T139	3.2	No	Yes	0	8	7
82	R:R:T139	R:R:V185	4.76	Yes	No	0	7	6
83	R:R:A140	R:R:W179	3.89	No	Yes	0	8	9
84	R:R:A140	R:R:S182	3.42	No	No	0	8	8
85	R:R:I142	R:R:P226	3.39	No	Yes	0	8	9
86	R:R:M143	R:R:V178	3.04	Yes	No	0	6	7
87	R:R:M143	R:R:P226	3.35	Yes	Yes	0	6	9
88	R:R:H144	R:R:V178	6.92	Yes	No	0	8	7
89	R:R:H144	R:R:W179	4.23	Yes	Yes	7	8	9
90	R:R:L145	R:R:N364	8.24	No	No	3	9	9
91	R:R:L145	R:R:Y368	5.86	No	Yes	3	9	9
92	R:R:C146	R:R:P226	3.77	No	Yes	0	7	9
93	R:R:C146	R:R:I229	3.27	No	No	0	7	6
94	R:R:I148	R:R:R152	3.76	Yes	No	3	9	9
95	R:R:I148	R:R:Y368	6.04	Yes	Yes	3	9	9
96	R:R:M230	R:R:S149	6.13	No	No	0	8	8
97	R:R:I229	R:R:L150	4.28	No	No	0	6	6
98	R:R:L150	R:R:T233	2.95	No	No	0	6	6
99	R:R:D151	R:R:H162	6.3	No	Yes	0	9	8
100	R:R:D151	R:R:K170	8.3	No	Yes	6	9	7
101	R:R:D151	R:R:K174	8.3	No	No	6	9	6
102	R:R:L313	R:R:R152	3.64	No	No	0	8	9
103	R:R:R152	R:R:Y368	6.17	No	Yes	3	9	9
104	R:R:R157	R:R:Y153	12.35	No	No	0	6	8
105	R:R:L236	R:R:Y153	9.38	No	No	0	6	8
106	R:R:T237	R:R:Y153	6.24	No	No	0	9	8
107	R:R:A155	R:R:H162	8.78	No	Yes	0	8	8
108	R:R:N158	R:R:R157	12.05	No	No	0	5	6
109	R:R:E161	R:R:N158	7.89	No	No	0	5	5
110	R:R:I160	R:R:R164	5.01	No	No	0	7	5
111	R:R:H162	R:R:N166	16.58	Yes	No	0	8	6
112	R:R:F165	R:R:K170	4.96	No	Yes	0	4	7
113	R:R:S167	R:R:T169	4.8	No	No	0	8	5
114	R:R:I172	R:R:R168	5.01	No	Yes	0	4	4
115	R:R:K170	R:R:K174	11.49	Yes	No	6	7	6
116	R:R:I189	R:R:S186	3.1	Yes	No	1	6	8
117	R:R:P188	R:R:V187	3.53	No	No	0	7	4
118	R:R:I189	R:R:P190	8.47	Yes	No	1	6	7
119	R:R:I192	R:R:K199	4.36	No	Yes	0	4	3
120	R:R:G193	R:R:V200	3.68	No	No	0	5	3
121	R:R:D196	R:R:E198	3.9	No	No	0	4	3
122	R:R:D196	R:R:K199	5.53	No	Yes	0	4	3
123	R:R:E197	R:R:F201	5.83	No	No	0	3	4
124	R:R:K199	R:R:V200	7.59	Yes	No	0	3	3
125	R:R:K199	R:R:L209	11.28	Yes	No	0	3	5
126	R:R:F201	R:R:V200	3.93	No	No	0	4	3
127	R:R:N203	R:R:V202	4.43	No	No	0	4	1
128	R:R:V202	R:R:V208	3.21	No	No	0	1	4
129	R:R:N210	R:R:V202	4.43	No	No	0	4	1
130	R:R:F214	R:R:L209	7.31	No	No	0	7	5
131	R:R:D211	R:R:P212	8.05	No	No	0	5	5
132	R:R:D211	R:R:N213	6.73	No	No	0	5	4
133	R:R:L216	R:R:P212	3.28	No	No	8	5	5
134	R:R:P212	R:R:V335	3.53	No	No	8	5	6
135	R:R:N331	R:R:V215	5.91	No	No	0	7	6
136	R:R:V215	R:R:V335	3.21	No	No	0	6	6
137	R:R:L216	R:R:V335	5.96	No	No	8	5	6
138	R:R:L216	R:R:L336	6.92	No	No	0	5	5
139	R:R:G218	R:R:I217	3.53	No	No	0	7	4
140	R:R:F220	R:R:F224	9.65	No	No	0	4	6
141	R:R:F223	R:R:F224	9.65	Yes	No	0	8	6
142	R:R:F223	R:R:W324	4.01	Yes	Yes	0	8	8
143	R:R:F223	R:R:F328	22.51	Yes	No	0	8	7
144	R:R:I225	R:R:P226	10.16	No	Yes	0	5	9
145	R:R:I232	R:R:T228	3.04	No	No	0	4	4
146	R:R:F320	R:R:M230	11.2	No	No	0	9	8
147	R:R:F317	R:R:V231	5.24	No	No	0	8	5
148	R:R:I238	R:R:Y234	12.09	No	No	0	5	9
149	R:R:G314	R:R:Y234	5.79	No	No	0	5	9
150	R:R:F317	R:R:Y234	3.09	No	No	0	8	9
151	R:R:L313	R:R:T237	2.95	No	No	0	8	9
152	R:R:I238	R:R:S310	3.1	No	No	0	5	7
153	R:R:R242	R:R:Y239	6.17	No	No	0	6	4
154	R:R:L241	R:R:S310	4.5	No	No	0	8	7
155	R:R:E306	R:R:Q244	6.37	No	No	0	7	7
156	R:R:A302	R:R:M300	4.83	No	No	0	4	3
157	R:R:I303	R:R:R307	3.76	No	No	0	4	5
158	R:R:F371	R:R:V312	5.24	No	No	0	7	8
159	R:R:V316	R:R:V367	3.21	No	No	0	8	8
160	R:R:V316	R:R:Y368	5.05	No	Yes	0	8	9
161	R:R:F320	R:R:W324	9.02	No	Yes	0	9	8
162	R:R:C325	R:R:L321	3.17	No	No	0	6	5
163	R:R:I322	R:R:M323	4.37	No	Yes	0	5	8
164	R:R:I356	R:R:M323	4.37	No	Yes	0	8	8
165	R:R:M323	R:R:V359	3.04	Yes	No	0	8	4
166	R:R:C360	R:R:M323	9.73	No	Yes	0	9	8
167	R:R:G357	R:R:W324	5.63	No	Yes	0	7	8
168	R:R:C360	R:R:W324	7.84	No	Yes	0	9	8
169	R:R:F353	R:R:P326	7.22	Yes	No	0	6	9
170	R:R:F327	R:R:F328	4.29	No	No	0	7	7
171	R:R:F327	R:R:V354	7.87	No	No	0	7	7
172	R:R:L350	R:R:T330	4.42	No	No	0	4	5
173	R:R:F353	R:R:T330	6.49	Yes	No	0	6	5
174	R:R:C337	R:R:L333	6.35	No	No	0	3	5
175	R:R:M346	R:R:S334	3.07	No	No	0	4	4
176	R:R:C337	R:R:C341	3.64	No	No	0	3	3
177	R:R:C341	R:R:E338	3.04	No	No	0	3	1
178	R:R:E338	R:R:Q343	14.02	No	No	0	1	1
179	R:R:C341	R:R:M346	3.24	No	No	0	3	4
180	R:R:K344	R:R:N342	9.79	No	No	0	1	4
181	R:R:L345	R:R:N342	4.12	No	No	0	4	4
182	R:R:E347	R:R:N351	5.26	No	No	0	3	5
183	R:R:V354	R:R:Y358	5.05	No	Yes	0	7	8
184	R:R:W355	R:R:Y358	3.86	Yes	Yes	0	7	8
185	R:R:G362	R:R:P365	4.06	No	No	0	7	9
186	R:R:N364	R:R:Y368	4.65	No	Yes	3	9	9
187	R:R:T369	R:R:Y375	6.24	No	No	0	7	8
188	R:R:I374	R:R:N372	8.5	No	No	0	6	8
189	R:R:K373	R:R:R376	6.19	No	No	0	5	9
190	R:R:I374	R:R:R377	5.01	No	No	0	6	4
191	R:R:N381	R:R:R377	3.62	No	No	0	5	4
192	R:R:I64	R:R:I65	2.94	Yes	No	0	7	4
193	R:R:I68	R:R:I72	2.94	No	No	0	6	4
194	R:R:I131	R:R:I189	2.94	No	Yes	1	5	6
195	R:R:I177	R:R:I181	2.94	No	No	0	2	4
196	R:R:I72	R:R:M76	2.92	No	No	0	4	5
197	R:R:I177	R:R:M173	2.92	No	No	0	2	3
198	R:R:I303	R:R:M300	2.92	No	No	0	4	3
199	R:R:I374	R:R:K83	2.91	No	No	0	6	5
200	R:R:I315	R:R:K311	2.91	No	No	0	6	7
201	R:R:I97	R:R:L101	2.85	No	No	0	6	6
202	R:R:I183	R:R:L136	2.85	No	Yes	0	4	6
203	R:R:I232	R:R:L236	2.85	No	No	0	4	6
204	R:R:I329	R:R:L333	2.85	No	No	0	6	5
205	R:R:A77	R:R:F379	2.77	No	No	0	7	7
206	R:R:L111	R:R:L115	2.77	No	No	0	6	5
207	R:R:A171	R:R:R168	2.77	No	Yes	0	8	4
208	R:R:D211	R:R:K199	2.77	No	Yes	0	5	3
209	R:R:L227	R:R:L321	2.77	No	No	0	6	5
210	R:R:L350	R:R:N331	2.75	No	No	0	4	7
211	R:R:E161	R:R:I160	2.73	No	No	0	5	7
212	R:R:A77	R:R:Y375	2.67	No	No	0	7	8
213	R:R:A98	R:R:W179	2.59	No	Yes	0	8	9
214	R:R:F224	R:R:I332	2.51	No	No	0	6	6
215	R:R:F317	R:R:M230	2.49	No	No	0	8	8
216	R:R:F137	R:R:L105	2.44	Yes	No	0	7	4
217	R:R:F223	R:R:L227	2.44	Yes	No	0	8	6
218	R:R:F353	R:R:L349	2.44	Yes	No	0	6	5
219	R:R:I114	R:R:W355	2.35	No	Yes	0	6	7
220	R:R:L73	R:R:Y382	2.34	No	No	0	7	5
221	R:R:Q244	R:R:R243	2.34	No	No	0	7	5
222	R:R:G69	R:R:G70	2.11	No	No	0	4	8
223	R:R:C127	R:R:P128	1.88	No	No	0	9	6
224	R:R:G69	R:R:I68	1.76	No	No	0	4	6
225	R:R:G184	R:R:I183	1.76	No	No	0	4	4
226	R:R:C235	R:R:V231	1.71	No	No	0	2	5
227	R:R:N158	R:R:P159	1.63	No	No	0	5	9
228	R:R:A245	R:R:I303	1.62	No	No	0	6	4
229	R:R:V312	R:R:V316	1.6	No	No	0	8	8
230	R:R:A309	R:R:L241	1.58	No	No	0	8	8
231	R:R:I64	R:R:V61	1.54	Yes	No	0	7	4
232	R:R:I156	R:R:V240	1.54	No	No	0	9	6
233	R:R:I315	R:R:V319	1.54	No	No	0	6	6
234	R:R:I315	R:R:V367	1.54	No	No	0	6	8
235	R:R:I363	R:R:V359	1.54	No	No	0	6	4
236	R:R:M93	R:R:S79	1.53	No	No	0	5	3
237	R:R:I156	R:R:T237	1.52	No	No	0	9	9
238	R:R:I172	R:R:T169	1.52	No	No	0	4	5
239	R:R:A245	R:R:E306	1.51	No	No	0	6	7
240	R:R:F318	R:R:G314	1.51	No	No	0	6	5
241	R:R:L111	R:R:V61	1.49	No	No	0	6	4
242	R:R:L126	R:R:V119	1.49	No	Yes	0	5	3
243	R:R:I72	R:R:I75	1.47	No	No	0	4	7
244	R:R:I75	R:R:I97	1.47	No	No	0	7	6
245	R:R:I181	R:R:M143	1.46	No	Yes	0	4	6
246	R:R:I172	R:R:M173	1.46	No	No	0	4	3
247	R:R:N203	R:R:T206	1.46	No	No	0	4	4
248	R:R:I148	R:R:L92	1.43	Yes	No	0	9	8
249	R:R:K83	R:R:L84	1.41	No	No	0	5	8
250	R:R:L246	R:R:M247	1.41	No	No	0	4	4
251	R:R:K373	R:R:N372	1.4	No	No	0	5	8
252	R:R:H162	R:R:V154	1.38	Yes	No	0	8	5
253	R:R:L366	R:R:L370	1.38	No	No	0	6	5
254	R:R:H85	R:R:T88	1.37	No	No	0	8	8
255	R:R:M247	R:R:Q244	1.36	No	No	0	4	7
256	R:R:E347	R:R:K344	1.35	No	No	0	3	1
257	R:R:E347	R:R:K348	1.35	No	No	0	3	3
258	R:R:N305	R:R:Q301	1.32	No	No	0	6	4
259	R:R:N342	R:R:Q343	1.32	No	No	0	4	1
260	R:R:F353	R:R:V352	1.31	Yes	No	0	6	5
261	R:R:V240	R:R:Y239	1.26	No	No	0	6	4
262	R:R:F371	R:R:K308	1.24	No	No	0	7	8
263	R:R:V119	R:R:W120	1.23	Yes	No	0	3	7
264	R:R:N304	R:R:R307	1.21	No	No	0	5	5
265	R:R:L370	R:R:R376	1.21	No	No	0	5	9
266	R:R:L115	R:R:Y116	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.34445	9	0	0
2	R:R:I64	3.624	5	0	7
3	R:R:T67	4.08	5	2	7
4	R:R:N71	6.556	5	2	9
5	R:R:F91	6.335	4	0	8
6	R:R:D99	8.91	4	2	9
7	R:R:V119	3.5075	4	0	3
8	R:R:S132	6.0175	4	1	6
9	R:R:L136	3.735	4	0	6
10	R:R:F137	5.674	5	0	7
11	R:R:T139	3.49	4	0	7
12	R:R:M143	2.715	4	0	6
13	R:R:H144	7.912	5	7	8
14	R:R:I148	4.0625	4	3	9
15	R:R:H162	8.26	4	0	8
16	R:R:R168	4.525	4	5	4
17	R:R:K170	7.3925	4	6	7
18	R:R:W179	4.18	5	7	9
19	R:R:I189	6.725	4	1	6
20	R:R:K199	6.306	5	0	3
21	R:R:F223	9.6525	4	0	8
22	R:R:P226	5.1675	4	0	9
23	R:R:M323	5.3775	4	0	8
24	R:R:W324	6.625	4	0	8
25	R:R:F353	4.365	4	0	6
26	R:R:W355	5.43	4	0	7
27	R:R:Y358	6.075	4	4	8
28	R:R:Y368	5.554	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D134	63.8199	15.17	Yes	No	0	0	8
2	R:R:W355	R:R:Y358	13.5516	3.86	Yes	Yes	0	7	8
3	R:R:D134	R:R:V106	53.9154	13.15	No	No	4	8	7
4	R:R:V102	R:R:V106	72.8695	3.21	No	No	0	7	7
5	R:R:G103	R:R:V102	44.3565	3.68	No	No	0	6	7
6	R:R:G103	R:R:M107	43.0014	5.24	No	No	0	6	8
7	R:R:I64	R:R:M107	47.1214	5.83	Yes	No	0	7	8
8	R:R:I64	R:R:I68	43.6744	4.42	Yes	No	0	7	6
9	R:R:S361	R:R:V102	27.2487	3.23	No	No	0	9	7
10	R:R:S361	R:R:T67	13.106	3.2	No	Yes	2	9	7
11	R:R:N71	R:R:T67	11.8781	4.39	Yes	Yes	2	9	7
12	R:R:D99	R:R:S361	12.7967	10.31	Yes	No	2	9	9
13	R:R:I68	R:R:I72	43.1287	2.94	No	No	0	6	4
14	R:R:I72	R:R:M76	73.6153	2.92	No	No	0	4	5
15	R:R:M76	R:R:Y382	70.9777	8.38	No	No	0	5	5
16	R:R:L73	R:R:Y382	60.5275	2.34	No	No	0	7	5
17	R:R:F379	R:R:L73	57.8172	7.31	No	No	0	7	7
18	L:L:?1	R:R:T139	100	2.99	Yes	Yes	0	0	7
19	R:R:S182	R:R:T139	47.0214	3.2	No	Yes	0	8	7
20	R:R:L136	R:R:S182	41.7372	3	Yes	No	0	6	8
21	R:R:F137	R:R:L136	38.663	6.09	Yes	Yes	0	7	6
22	R:R:F137	R:R:L101	55.7981	12.18	Yes	No	0	7	6
23	R:R:I97	R:R:L101	54.6248	2.85	No	No	0	6	6
24	R:R:I75	R:R:I97	53.4516	1.47	No	No	0	7	6
25	R:R:I72	R:R:I75	52.4329	1.47	No	No	0	4	7
26	R:R:A77	R:R:F379	55.0978	2.77	No	No	0	7	7
27	R:R:A77	R:R:Y375	52.3693	2.67	No	No	0	7	8
28	R:R:N89	R:R:Y375	46.8122	6.98	No	No	0	9	8
29	R:R:L84	R:R:N89	38.5266	9.61	No	No	0	8	9
30	R:R:M143	R:R:T139	68.2492	3.01	Yes	Yes	0	6	7
31	R:R:M143	R:R:V178	52.7512	3.04	Yes	No	0	6	7
32	R:R:H144	R:R:V178	52.4511	6.92	Yes	No	0	8	7
33	R:R:F91	R:R:H144	68.4857	12.44	Yes	Yes	0	8	8
34	R:R:F91	R:R:K174	20.864	3.72	Yes	No	0	8	6
35	R:R:I181	R:R:M143	17.3261	1.46	No	Yes	0	4	6
36	R:R:I177	R:R:I181	15.0887	2.94	No	No	0	2	4
37	R:R:I177	R:R:M173	12.915	2.92	No	No	0	2	3
38	R:R:I172	R:R:M173	10.7867	1.46	No	No	0	4	3
39	R:R:F91	R:R:I148	53.6426	5.02	Yes	Yes	0	8	9
40	R:R:I64	R:R:V61	11.3961	1.54	Yes	No	0	7	4
41	L:L:?1	R:R:F214	66.1573	8.66	Yes	No	0	0	7
42	R:R:F214	R:R:L209	64.5748	7.31	No	No	0	7	5
43	R:R:K199	R:R:L209	62.9923	11.28	Yes	No	0	3	5
44	R:R:K199	R:R:V200	28.6312	7.59	Yes	No	0	3	3
45	R:R:F201	R:R:V200	24.3929	3.93	No	No	0	4	3
46	R:R:F201	R:R:V119	20.0819	6.55	No	Yes	0	4	3
47	R:R:T206	R:R:V119	13.688	4.76	No	Yes	0	4	3
48	R:R:L136	R:R:S186	19.7271	3	Yes	No	0	6	8
49	R:R:I189	R:R:S186	11.7417	3.1	Yes	No	1	6	8
50	R:R:M143	R:R:P226	16.5439	3.35	Yes	Yes	0	6	9
51	R:R:I148	R:R:Y368	19.7544	6.04	Yes	Yes	3	9	9
52	R:R:I148	R:R:R152	30.7412	3.76	Yes	No	3	9	9
53	L:L:?1	R:R:F327	60.6821	4.95	Yes	No	0	0	7
54	R:R:F327	R:R:F328	75.1614	4.29	No	No	0	7	7
55	R:R:F223	R:R:F328	72.824	22.51	Yes	No	0	8	7
56	R:R:F223	R:R:W324	55.9527	4.01	Yes	Yes	0	8	8
57	R:R:F320	R:R:W324	35.5798	9.02	No	Yes	0	9	8
58	R:R:F320	R:R:M230	32.9513	11.2	No	No	0	9	8
59	R:R:L313	R:R:R152	30.7776	3.64	No	No	0	8	9
60	R:R:L313	R:R:T237	29.1678	2.95	No	No	0	8	9
61	R:R:T237	R:R:Y153	19.909	6.24	No	No	0	9	8
62	R:R:R157	R:R:Y153	12.1601	12.35	No	No	0	6	8
63	R:R:N158	R:R:R157	10.1774	12.05	No	No	0	5	6
64	R:R:D211	R:R:K199	30.3683	2.77	No	Yes	0	5	3
65	R:R:D211	R:R:P212	26.1664	8.05	No	No	0	5	5
66	R:R:P212	R:R:V335	19.7453	3.53	No	No	8	5	6
67	R:R:V215	R:R:V335	17.899	3.21	No	No	0	6	6
68	R:R:N331	R:R:V215	15.7071	5.91	No	No	0	7	6
69	R:R:F317	R:R:M230	27.6398	2.49	No	No	0	8	8
70	R:R:F317	R:R:Y234	19.5362	3.09	No	No	0	8	9
71	R:R:I238	R:R:Y234	11.2688	12.09	No	No	0	5	9
72	R:R:V316	R:R:Y368	15.8527	5.05	No	Yes	0	8	9
73	R:R:C360	R:R:W324	16.7985	7.84	No	Yes	0	9	8
74	R:R:C360	R:R:M323	14.0427	9.73	No	Yes	0	9	8
75	R:R:L350	R:R:N331	13.4879	2.75	No	No	0	4	7
76	R:R:L350	R:R:T330	11.4325	4.42	No	No	0	4	5
77	R:R:F327	R:R:V354	19.2087	7.87	No	No	0	7	7
78	R:R:K83	R:R:L84	26.985	1.41	No	No	0	5	8
79	R:R:I374	R:R:K83	24.0564	2.91	No	No	0	6	5
80	R:R:I374	R:R:N372	15.1796	8.5	No	No	0	6	8
81	R:R:K373	R:R:N372	12.1783	1.4	No	No	0	5	8
82	R:R:V354	R:R:Y358	18.3356	5.05	No	Yes	0	7	8
83	R:R:V106	R:R:Y358	20.2547	5.05	No	Yes	4	7	8
84	R:R:H144	R:R:W179	31.7417	4.23	Yes	Yes	7	8	9
85	R:R:F137	R:R:W179	32.5057	4.01	Yes	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D134	15.17	0	Yes	No	0	8	0	1
L:L:?1	R:R:V135	22.7	0	Yes	No	0	6	0	1
L:L:?1	R:R:S138	9.15	0	Yes	No	0	6	0	1
L:L:?1	R:R:T139	2.99	0	Yes	Yes	0	7	0	1
L:L:?1	R:R:F214	8.66	0	Yes	No	0	7	0	1
L:L:?1	R:R:G218	3.48	0	Yes	No	0	7	0	1
L:L:?1	R:R:S219	12.2	0	Yes	No	0	7	0	1
L:L:?1	R:R:A222	4.8	0	Yes	No	0	7	0	1
L:L:?1	R:R:F327	4.95	0	Yes	No	0	7	0	1
R:R:D134	R:R:V106	13.15	4	No	No	8	7	1	2
R:R:V106	R:R:Y358	5.05	4	No	Yes	7	8	2	2
R:R:D134	R:R:Y358	10.34	4	No	Yes	8	8	1	2
R:R:V135	R:R:V185	3.21	0	No	No	6	6	1	2
R:R:M143	R:R:T139	3.01	0	Yes	Yes	6	7	2	1
R:R:S182	R:R:T139	3.2	0	No	Yes	8	7	2	1
R:R:T139	R:R:V185	4.76	0	Yes	No	7	6	1	2
R:R:F214	R:R:L209	7.31	0	No	No	7	5	1	2
R:R:G218	R:R:I217	3.53	0	No	No	7	4	1	2
R:R:F327	R:R:F328	4.29	0	No	No	7	7	1	2
R:R:F327	R:R:V354	7.87	0	No	No	7	7	1	2
R:R:V354	R:R:Y358	5.05	0	No	Yes	7	8	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DPG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	250
Number of Links	266
Number of Hubs	28
Number of Links mediated by Hubs	110
Number of Communities	8
Number of Nodes involved in Communities	32
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	29797
Length Of Smallest Path	3
Average Path Length	14.4526
Length of Longest Path	36
Minimum Path Strength	1.295
Average Path Strength	5.77839
Maximum Path Strength	18.935
Minimum Path Correlation	0.7
Average Path Correlation	0.920781
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	46.8561
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.7922
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • Gq/11-coupled serotonin receptor activity • identical protein binding • protein binding • behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • system process • nervous system process • regulation of system process • regulation of multicellular organismal process • regulation of nervous system process • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • corticotropin-releasing hormone secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of corticotropin-releasing hormone secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • hormone transport • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of lipid metabolic process • glycerophospholipid metabolic process • lipid biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • phospholipid metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of lipid metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • regulation of phosphatidylinositol biosynthetic process • regulation of biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • primary metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • biosynthetic process • positive regulation of lipid biosynthetic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • metabolic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • cGMP-mediated signaling • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • feeding behavior • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cellular localization • monoatomic ion transmembrane transport • negative regulation of biological process • negative regulation of sequestering of calcium ion • calcium ion transport • metal ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • negative regulation of cellular process • monoatomic ion transport • monoatomic cation transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • response to nutrient levels • regulation of appetite • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • developmental process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse
Gene Ontology	Cellular Component	• protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	91Q
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	91Q
Name	3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol
Synonyms
Identifier
Formula	C12 H16 N2 O
Molecular Weight	204.268
SMILES
PubChem	4980
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	32
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28335
Sequence	>8DPG_nogp_Chain_R S I V I I I I M T I G G N I L V I M A V S M E K K L H N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D Y V W L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N P I E H S R F N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D E E K V F V N T C V L N D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C E C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I Y R R A F S N Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZMF	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	A1L10	-	-	3.6	2024-08-28	10.1021/acs.jmedchem.4c01244
	8DPI	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.4	2022-08-24	10.1016/j.celrep.2022.111211
	8DPI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-		3.4	2022-08-24	10.1016/j.celrep.2022.111211
	8DPH	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.2	2022-08-24	10.1016/j.celrep.2022.111211
	8DPH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-		3.2	2022-08-24	10.1016/j.celrep.2022.111211
	8DPG	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Psilocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.6	2022-08-24	10.1016/j.celrep.2022.111211
	8DPG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Psilocin	-		3.6	2022-08-24	10.1016/j.celrep.2022.111211
	8DPF	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.84	2022-08-24	10.1016/j.celrep.2022.111211
	8DPF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-		2.84	2022-08-24	10.1016/j.celrep.2022.111211
	6BQH	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Ritanserin	-	-	2.7	2018-02-14	10.1016/j.cell.2018.01.001
	6BQG	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Ergotamine	-	-	3	2018-02-14	10.1016/j.cell.2018.01.001

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