psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D134	23.92	Yes	Yes	1	0	8
2	L:L:?1	R:R:V135	19.25	Yes	No	0	0	6
3	L:L:?1	R:R:S138	15.88	Yes	No	0	0	6
4	L:L:?1	R:R:F327	5.72	Yes	No	1	0	7
5	L:L:?1	R:R:V354	3.5	Yes	No	1	0	7
6	L:L:?1	R:R:Y358	4.13	Yes	Yes	1	0	8
7	R:R:I60	R:R:I63	4.42	No	No	0	7	7
8	R:R:I60	R:R:W355	8.22	No	Yes	0	7	7
9	R:R:I64	R:R:V61	3.07	No	No	0	7	4
10	R:R:I64	R:R:I65	4.42	No	No	0	7	4
11	R:R:I64	R:R:M107	5.83	No	No	0	7	8
12	R:R:N71	R:R:T67	4.39	Yes	No	0	9	7
13	R:R:G362	R:R:T67	5.46	No	No	0	7	7
14	R:R:I68	R:R:I72	2.94	No	No	0	6	4
15	R:R:I68	R:R:L104	2.85	No	No	0	6	4
16	R:R:D99	R:R:N71	16.16	No	Yes	2	9	9
17	R:R:M100	R:R:N71	4.21	No	Yes	2	7	9
18	R:R:N71	R:R:P365	6.52	Yes	No	2	9	9
19	R:R:F379	R:R:L73	7.31	No	No	0	7	7
20	R:R:A96	R:R:V74	3.39	No	No	0	9	9
21	R:R:P365	R:R:V74	3.53	No	No	0	9	9
22	R:R:M76	R:R:S79	3.07	No	No	0	5	3
23	R:R:M76	R:R:M80	5.78	No	No	6	5	5
24	R:R:M76	R:R:Y382	3.59	No	No	6	5	5
25	R:R:A77	R:R:F379	2.77	No	No	0	7	7
26	R:R:L84	R:R:V78	2.98	No	No	0	8	8
27	R:R:M93	R:R:V78	9.13	No	No	0	5	8
28	R:R:E81	R:R:M80	8.12	No	No	0	6	5
29	R:R:M80	R:R:Y382	16.76	No	No	6	5	5
30	R:R:A378	R:R:E81	6.03	No	No	0	7	6
31	R:R:L84	R:R:N89	10.98	No	No	0	8	9
32	R:R:A87	R:R:N86	3.13	No	Yes	0	5	7
33	R:R:N86	R:R:Y90	11.63	Yes	No	7	7	4
34	R:R:N86	R:R:R168	4.82	Yes	No	7	7	4
35	R:R:A87	R:R:N166	3.13	No	No	0	5	6
36	R:R:N89	R:R:T88	4.39	No	No	0	9	8
37	R:R:N89	R:R:Y375	5.81	No	Yes	0	9	8
38	R:R:R168	R:R:Y90	5.14	No	No	7	4	4
39	R:R:F91	R:R:H144	11.31	Yes	Yes	0	8	8
40	R:R:A147	R:R:F91	4.16	No	Yes	0	7	8
41	R:R:F91	R:R:I148	5.02	Yes	Yes	0	8	9
42	R:R:F91	R:R:K174	3.72	Yes	No	0	8	6
43	R:R:H144	R:R:S94	6.97	Yes	No	5	8	9
44	R:R:I175	R:R:S94	3.1	No	No	0	8	9
45	R:R:S94	R:R:W179	6.18	No	Yes	5	9	9
46	R:R:L95	R:R:S141	3	No	No	0	9	9
47	R:R:H144	R:R:L95	10.29	Yes	No	0	8	9
48	R:R:I97	R:R:M100	8.75	No	No	2	6	7
49	R:R:I97	R:R:L101	2.85	No	No	2	6	6
50	R:R:D99	R:R:S361	8.83	No	No	0	9	9
51	R:R:D99	R:R:P365	9.66	No	No	2	9	9
52	R:R:L101	R:R:M100	9.9	No	No	2	6	7
53	R:R:F137	R:R:L101	12.18	Yes	No	0	7	6
54	R:R:V102	R:R:V106	3.21	No	No	0	7	7
55	R:R:S361	R:R:V102	3.23	No	No	0	9	7
56	R:R:G103	R:R:M107	6.99	No	No	0	6	8
57	R:R:D134	R:R:V106	11.69	Yes	No	1	8	7
58	R:R:V106	R:R:Y358	5.05	No	Yes	1	7	8
59	R:R:I114	R:R:S110	3.1	No	No	1	6	7
60	R:R:S110	R:R:W355	6.18	No	Yes	1	7	7
61	R:R:I114	R:R:L111	2.85	No	No	0	6	6
62	R:R:L112	R:R:Y116	8.21	No	No	0	4	5
63	R:R:I114	R:R:W355	4.7	No	Yes	1	6	7
64	R:R:T206	R:R:Y118	3.75	No	No	0	4	4
65	R:R:F201	R:R:V119	6.55	Yes	No	0	4	3
66	R:R:T206	R:R:V119	3.17	No	No	0	4	3
67	R:R:L126	R:R:W130	5.69	No	No	0	5	5
68	R:R:C127	R:R:I131	3.27	Yes	Yes	3	9	5
69	R:R:C127	R:R:F201	2.79	Yes	Yes	0	9	4
70	R:R:C127	R:R:C207	7.28	Yes	No	3	9	9
71	R:R:L133	R:R:V129	2.98	No	No	0	5	4
72	R:R:D134	R:R:W130	3.35	Yes	No	0	8	5
73	R:R:C207	R:R:W130	3.92	No	No	0	9	5
74	R:R:I131	R:R:I189	4.42	Yes	Yes	3	5	6
75	R:R:C207	R:R:I131	3.27	No	Yes	3	9	5
76	R:R:I131	R:R:L209	2.85	Yes	No	0	5	5
77	R:R:I189	R:R:S132	9.29	Yes	No	3	6	6
78	R:R:P190	R:R:S132	7.13	No	No	3	7	6
79	R:R:F137	R:R:L133	3.65	Yes	No	0	7	5
80	R:R:D134	R:R:Y358	10.34	Yes	Yes	1	8	8
81	R:R:V135	R:R:V185	3.21	No	No	0	6	6
82	R:R:S186	R:R:V135	3.23	No	No	0	8	6
83	R:R:F137	R:R:L136	6.09	Yes	Yes	0	7	6
84	R:R:L136	R:R:S182	3	Yes	No	0	6	8
85	R:R:I183	R:R:L136	2.85	No	Yes	0	4	6
86	R:R:L136	R:R:S186	4.5	Yes	No	0	6	8
87	R:R:F137	R:R:W179	4.01	Yes	Yes	0	7	9
88	R:R:M143	R:R:T139	3.01	No	Yes	0	6	7
89	R:R:S182	R:R:T139	3.2	No	Yes	0	8	7
90	R:R:T139	R:R:V185	4.76	Yes	No	0	7	6
91	R:R:A140	R:R:H144	2.93	No	Yes	5	8	8
92	R:R:A140	R:R:W179	3.89	No	Yes	5	8	9
93	R:R:A140	R:R:S182	3.42	No	No	0	8	8
94	R:R:I142	R:R:P226	3.39	No	Yes	0	8	9
95	R:R:M143	R:R:V178	3.04	No	No	0	6	7
96	R:R:H144	R:R:V178	6.92	Yes	No	0	8	7
97	R:R:H144	R:R:W179	4.23	Yes	Yes	5	8	9
98	R:R:L145	R:R:N364	8.24	No	No	4	9	9
99	R:R:L145	R:R:Y368	5.86	No	Yes	4	9	9
100	R:R:C146	R:R:I229	3.27	No	No	0	7	6
101	R:R:I148	R:R:R152	3.76	Yes	No	4	9	9
102	R:R:I148	R:R:Y368	6.04	Yes	Yes	4	9	9
103	R:R:M230	R:R:S149	3.07	No	No	0	8	8
104	R:R:I229	R:R:L150	4.28	No	No	0	6	6
105	R:R:D151	R:R:H162	6.3	No	No	0	9	8
106	R:R:D151	R:R:K170	2.77	No	Yes	0	9	7
107	R:R:L313	R:R:R152	3.64	No	No	0	8	9
108	R:R:R152	R:R:Y368	7.2	No	Yes	4	9	9
109	R:R:R157	R:R:Y153	7.2	No	Yes	0	6	8
110	R:R:L236	R:R:Y153	7.03	No	Yes	0	6	8
111	R:R:T237	R:R:Y153	6.24	No	Yes	0	9	8
112	R:R:R157	R:R:V154	7.85	No	No	0	6	5
113	R:R:A155	R:R:H162	7.32	No	No	0	8	8
114	R:R:R157	R:R:S158	10.54	No	No	0	6	5
115	R:R:E161	R:R:S158	10.06	No	No	0	5	5
116	R:R:E161	R:R:V160	2.85	No	No	0	5	7
117	R:R:H162	R:R:N166	12.75	No	No	0	8	6
118	R:R:F165	R:R:K170	8.69	No	Yes	0	4	7
119	R:R:S167	R:R:T169	6.4	No	No	0	8	5
120	R:R:K170	R:R:K174	14.37	Yes	No	8	7	6
121	R:R:I177	R:R:M173	2.92	No	Yes	0	2	3
122	R:R:I177	R:R:I181	2.94	No	No	0	2	4
123	R:R:P188	R:R:V187	3.53	No	No	0	7	4
124	R:R:I189	R:R:P190	3.39	Yes	No	3	6	7
125	R:R:F214	R:R:I189	11.3	No	Yes	0	7	6
126	R:R:I192	R:R:K199	15.99	No	Yes	0	4	3
127	R:R:G193	R:R:V200	3.68	No	No	0	5	3
128	R:R:L194	R:R:R195	4.86	No	No	0	6	5
129	R:R:D196	R:R:K199	4.15	No	Yes	0	4	3
130	R:R:E197	R:R:F201	7	No	Yes	0	3	4
131	R:R:K199	R:R:V200	3.04	Yes	No	0	3	3
132	R:R:D211	R:R:K199	5.53	No	Yes	0	5	3
133	R:R:F201	R:R:V200	3.93	Yes	No	0	4	3
134	R:R:V202	R:R:V208	3.21	No	No	0	1	4
135	R:R:N210	R:R:V202	2.96	No	No	0	4	1
136	R:R:F214	R:R:L209	7.31	No	No	0	7	5
137	R:R:D211	R:R:P212	8.05	No	No	0	5	5
138	R:R:D211	R:R:N213	16.16	No	No	0	5	4
139	R:R:L216	R:R:P212	3.28	No	No	9	5	5
140	R:R:P212	R:R:V335	3.53	No	No	9	5	6
141	R:R:N331	R:R:V215	5.91	No	No	0	7	6
142	R:R:L216	R:R:V335	5.96	No	No	9	5	6
143	R:R:L216	R:R:L336	5.54	No	No	0	5	5
144	R:R:G218	R:R:I217	3.53	No	No	0	7	4
145	R:R:F220	R:R:F224	9.65	No	Yes	0	4	6
146	R:R:F223	R:R:F224	9.65	Yes	Yes	10	8	6
147	R:R:F223	R:R:W324	4.01	Yes	Yes	0	8	8
148	R:R:F223	R:R:F328	28.94	Yes	No	10	8	7
149	R:R:F224	R:R:F328	3.22	Yes	No	10	6	7
150	R:R:I225	R:R:P226	10.16	No	Yes	0	5	9
151	R:R:L227	R:R:L321	2.77	No	No	0	6	5
152	R:R:I232	R:R:T228	3.04	No	No	0	4	4
153	R:R:F320	R:R:M230	12.44	No	No	0	9	8
154	R:R:F317	R:R:V231	5.24	No	No	0	8	5
155	R:R:I232	R:R:L236	2.85	No	No	0	4	6
156	R:R:I238	R:R:Y234	12.09	No	Yes	0	5	9
157	R:R:G314	R:R:Y234	5.79	No	Yes	0	5	9
158	R:R:F317	R:R:Y234	4.13	No	Yes	0	8	9
159	R:R:L313	R:R:T237	2.95	No	No	0	8	9
160	R:R:I238	R:R:S310	3.1	No	No	0	5	7
161	R:R:L241	R:R:S310	6.01	No	No	0	8	7
162	R:R:E306	R:R:Q244	6.37	No	No	0	7	7
163	R:R:A302	R:R:M300	4.83	No	No	0	4	3
164	R:R:I303	R:R:M300	4.37	No	No	0	4	3
165	R:R:I303	R:R:R307	3.76	No	No	0	4	5
166	R:R:I315	R:R:K311	2.91	No	No	0	6	7
167	R:R:F371	R:R:V312	5.24	No	No	0	7	8
168	R:R:V316	R:R:Y368	5.05	No	Yes	0	8	9
169	R:R:F320	R:R:W324	9.02	No	Yes	0	9	8
170	R:R:C325	R:R:L321	3.17	No	No	0	6	5
171	R:R:I322	R:R:M323	2.92	No	Yes	0	5	8
172	R:R:I356	R:R:M323	2.92	No	Yes	0	8	8
173	R:R:M323	R:R:V359	3.04	Yes	No	0	8	4
174	R:R:C360	R:R:M323	8.1	No	Yes	0	9	8
175	R:R:G357	R:R:W324	5.63	No	Yes	0	7	8
176	R:R:C360	R:R:W324	7.84	No	Yes	0	9	8
177	R:R:F353	R:R:P326	5.78	No	No	0	6	9
178	R:R:F327	R:R:L350	3.65	No	No	0	7	4
179	R:R:F327	R:R:V354	7.87	No	No	1	7	7
180	R:R:I329	R:R:L333	2.85	No	No	0	6	5
181	R:R:L350	R:R:T330	4.42	No	Yes	0	4	5
182	R:R:F353	R:R:T330	7.78	No	Yes	0	6	5
183	R:R:L350	R:R:N331	2.75	No	No	0	4	7
184	R:R:C337	R:R:L333	3.17	No	No	0	3	5
185	R:R:M346	R:R:S334	4.6	No	No	0	4	4
186	R:R:C337	R:R:C341	5.46	No	No	0	3	3
187	R:R:C341	R:R:E338	4.56	No	No	0	3	1
188	R:R:E338	R:R:Q343	11.47	No	No	0	1	1
189	R:R:C341	R:R:M346	3.24	No	No	0	3	4
190	R:R:K344	R:R:N342	6.99	No	No	0	1	4
191	R:R:L345	R:R:N342	4.12	No	No	0	4	4
192	R:R:E347	R:R:N351	5.26	No	No	0	3	5
193	R:R:V354	R:R:Y358	5.05	No	Yes	1	7	8
194	R:R:W355	R:R:Y358	9.65	Yes	Yes	1	7	8
195	R:R:N364	R:R:Y368	3.49	No	Yes	4	9	9
196	R:R:T369	R:R:Y375	6.24	No	Yes	0	7	8
197	R:R:K373	R:R:N372	2.8	No	No	0	5	8
198	R:R:I374	R:R:N372	7.08	No	No	0	6	8
199	R:R:N381	R:R:R377	3.62	No	No	0	5	4
200	R:R:E347	R:R:K344	2.7	No	No	0	3	1
201	R:R:A77	R:R:Y375	2.67	No	Yes	0	7	8
202	R:R:F328	R:R:S219	2.64	No	No	0	7	7
203	R:R:A98	R:R:W179	2.59	No	Yes	0	8	9
204	R:R:V78	R:R:Y90	2.52	No	No	0	8	4
205	R:R:V367	R:R:Y368	2.52	No	Yes	0	8	9
206	R:R:F224	R:R:I332	2.51	Yes	No	0	6	6
207	R:R:T233	R:R:Y153	2.5	No	Yes	0	6	8
208	R:R:K373	R:R:R376	2.48	No	No	0	5	9
209	R:R:F137	R:R:L105	2.44	Yes	No	0	7	4
210	R:R:F320	R:R:L145	2.44	No	No	0	9	9
211	R:R:F223	R:R:L227	2.44	Yes	No	0	8	6
212	R:R:L313	R:R:Y234	2.34	No	Yes	0	8	9
213	R:R:G69	R:R:G70	2.11	No	No	0	4	8
214	R:R:C127	R:R:P128	1.88	Yes	No	0	9	6
215	R:R:C146	R:R:P226	1.88	No	Yes	0	7	9
216	R:R:G103	R:R:V102	1.84	No	No	0	6	7
217	R:R:P159	R:R:S158	1.78	No	No	0	9	5
218	R:R:G69	R:R:I68	1.76	No	No	0	4	6
219	R:R:G184	R:R:I183	1.76	No	No	0	4	4
220	R:R:G70	R:R:L73	1.71	No	No	0	8	7
221	R:R:C235	R:R:V231	1.71	No	No	0	2	5
222	R:R:M107	R:R:P108	1.68	No	No	0	8	9
223	R:R:A222	R:R:T139	1.68	No	Yes	0	7	7
224	R:R:M143	R:R:P226	1.68	No	Yes	0	6	9
225	R:R:A245	R:R:I303	1.62	No	No	0	6	4
226	R:R:V312	R:R:V316	1.6	No	No	0	8	8
227	R:R:T237	R:R:V156	1.59	No	No	0	9	9
228	R:R:A309	R:R:L241	1.58	No	No	0	8	8
229	R:R:A171	R:R:N86	1.56	No	Yes	0	8	7
230	R:R:I315	R:R:V319	1.54	No	No	0	6	6
231	R:R:I315	R:R:V367	1.54	No	No	0	6	8
232	R:R:I363	R:R:V319	1.54	No	No	0	6	6
233	R:R:I363	R:R:V359	1.54	No	No	0	6	4
234	R:R:A77	R:R:E81	1.51	No	No	0	7	6
235	R:R:A245	R:R:E306	1.51	No	No	0	6	7
236	R:R:F318	R:R:G314	1.51	No	No	0	6	5
237	R:R:M346	R:R:T330	1.51	No	Yes	0	4	5
238	R:R:N203	R:R:V202	1.48	No	No	0	4	1
239	R:R:I75	R:R:I97	1.47	No	No	0	7	6
240	R:R:L349	R:R:T330	1.47	No	Yes	0	5	5
241	R:R:I172	R:R:M173	1.46	No	Yes	0	4	3
242	R:R:K170	R:R:M173	1.44	Yes	Yes	8	7	3
243	R:R:K174	R:R:M173	1.44	No	Yes	8	6	3
244	R:R:K344	R:R:K348	1.44	No	No	0	1	3
245	R:R:I148	R:R:L92	1.43	Yes	No	0	9	8
246	R:R:L366	R:R:M66	1.41	No	No	0	6	4
247	R:R:L246	R:R:M247	1.41	No	No	0	4	4
248	R:R:L109	R:R:L126	1.38	No	No	0	5	5
249	R:R:L366	R:R:L370	1.38	No	No	0	6	5
250	R:R:H85	R:R:T88	1.37	No	No	0	8	8
251	R:R:M247	R:R:Q244	1.36	No	No	0	4	7
252	R:R:N305	R:R:Q301	1.32	No	No	0	6	4
253	R:R:R164	R:R:V160	1.31	No	No	0	5	7
254	R:R:F353	R:R:V352	1.31	No	No	0	6	5
255	R:R:D196	R:R:E198	1.3	No	No	0	4	3
256	R:R:V240	R:R:Y153	1.26	No	Yes	0	6	8
257	R:R:M247	R:R:R243	1.24	No	No	0	4	5
258	R:R:F371	R:R:K308	1.24	No	No	0	7	8
259	R:R:V119	R:R:W120	1.23	No	No	0	3	7
260	R:R:N304	R:R:R307	1.21	No	No	0	5	5
261	R:R:L115	R:R:Y116	1.17	No	No	0	5	5
262	R:R:N372	R:R:Y375	1.16	No	Yes	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.0667	6	1	0
2	R:R:N71	7.82	4	2	9
3	R:R:N86	5.285	4	7	7
4	R:R:F91	6.0525	4	0	8
5	R:R:C127	3.805	4	3	9
6	R:R:I131	3.4525	4	3	5
7	R:R:D134	12.325	4	1	8
8	R:R:L136	4.11	4	0	6
9	R:R:F137	5.674	5	0	7
10	R:R:T139	3.1625	4	0	7
11	R:R:H144	7.10833	6	5	8
12	R:R:I148	4.0625	4	4	9
13	R:R:Y153	4.846	5	0	8
14	R:R:K170	6.8175	4	8	7
15	R:R:M173	1.815	4	8	3
16	R:R:W179	4.18	5	5	9
17	R:R:I189	7.1	4	3	6
18	R:R:K199	7.1775	4	0	3
19	R:R:F201	5.0675	4	0	4
20	R:R:F223	11.26	4	10	8
21	R:R:F224	6.2575	4	10	6
22	R:R:P226	4.2775	4	0	9
23	R:R:Y234	6.0875	4	0	9
24	R:R:M323	4.245	4	0	8
25	R:R:W324	6.625	4	0	8
26	R:R:T330	3.795	4	0	5
27	R:R:W355	7.1875	4	1	7
28	R:R:Y358	6.844	5	1	8
29	R:R:Y368	5.02667	6	4	9
30	R:R:Y375	3.97	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y358	13.3547	4.13	Yes	Yes	1	0	8
2	R:R:W355	R:R:Y358	10.0519	9.65	Yes	Yes	1	7	8
3	L:L:?1	R:R:D134	51.6252	23.92	Yes	Yes	1	0	8
4	L:L:?1	R:R:V135	89.9546	19.25	Yes	No	0	0	6
5	R:R:V135	R:R:V185	45.4052	3.21	No	No	0	6	6
6	R:R:T139	R:R:V185	45.8855	4.76	Yes	No	0	7	6
7	R:R:M143	R:R:T139	24.697	3.01	No	Yes	0	6	7
8	R:R:M143	R:R:V178	25.2687	3.04	No	No	0	6	7
9	R:R:H144	R:R:V178	25.4157	6.92	Yes	No	0	8	7
10	R:R:F91	R:R:H144	100	11.31	Yes	Yes	0	8	8
11	R:R:F91	R:R:K174	48.463	3.72	Yes	No	0	8	6
12	R:R:K170	R:R:K174	42.6383	14.37	Yes	No	8	7	6
13	R:R:D151	R:R:K170	41.1486	2.77	No	Yes	0	9	7
14	R:R:D151	R:R:H162	40.2306	6.3	No	No	0	9	8
15	R:R:H162	R:R:N166	38.2281	12.75	No	No	0	8	6
16	R:R:A87	R:R:N166	37.0945	3.13	No	No	0	5	6
17	R:R:A87	R:R:N86	35.9707	3.13	No	Yes	0	5	7
18	R:R:N86	R:R:Y90	32.4622	11.63	Yes	No	7	7	4
19	R:R:V78	R:R:Y90	31.3809	2.52	No	No	0	8	4
20	R:R:L84	R:R:V78	29.2803	2.98	No	No	0	8	8
21	R:R:L84	R:R:N89	28.1075	10.98	No	No	0	8	9
22	R:R:N89	R:R:Y375	24.5435	5.81	No	Yes	0	9	8
23	R:R:A77	R:R:Y375	17.4741	2.67	No	Yes	0	7	8
24	R:R:S182	R:R:T139	23.2955	3.2	No	Yes	0	8	7
25	R:R:A140	R:R:S182	45.4771	3.42	No	No	0	8	8
26	R:R:A140	R:R:H144	45.2615	2.93	No	Yes	5	8	8
27	R:R:S186	R:R:V135	45.9704	3.23	No	No	0	8	6
28	R:R:L136	R:R:S186	46.4964	4.5	Yes	No	0	6	8
29	R:R:L136	R:R:S182	23.6549	3	Yes	No	0	6	8
30	R:R:F137	R:R:L136	25.5921	6.09	Yes	Yes	0	7	6
31	R:R:F137	R:R:W179	32.1257	4.01	Yes	Yes	0	7	9
32	R:R:H144	R:R:W179	31.639	4.23	Yes	Yes	5	8	9
33	R:R:F91	R:R:I148	66.3846	5.02	Yes	Yes	0	8	9
34	R:R:D134	R:R:W130	49.8024	3.35	Yes	No	0	8	5
35	R:R:C207	R:R:W130	45.3105	3.92	No	No	0	9	5
36	R:R:C127	R:R:C207	32.9914	7.28	Yes	No	3	9	9
37	R:R:C127	R:R:F201	30.1754	2.79	Yes	Yes	0	9	4
38	R:R:C207	R:R:I131	10.9209	3.27	No	Yes	3	9	5
39	R:R:I148	R:R:Y368	34.4223	6.04	Yes	Yes	4	9	9
40	R:R:L145	R:R:Y368	23.5569	5.86	No	Yes	4	9	9
41	R:R:I148	R:R:R152	30.0546	3.76	Yes	No	4	9	9
42	R:R:F320	R:R:L145	22.4429	2.44	No	No	0	9	9
43	R:R:L313	R:R:R152	31.8023	3.64	No	No	0	8	9
44	R:R:L313	R:R:T237	19.1467	2.95	No	No	0	8	9
45	R:R:T237	R:R:Y153	16.6868	6.24	No	Yes	0	9	8
46	R:R:F201	R:R:V200	20.2117	3.93	Yes	No	0	4	3
47	R:R:K199	R:R:V200	16.8404	3.04	Yes	No	0	3	3
48	R:R:D211	R:R:K199	10.0193	5.53	No	Yes	0	5	3
49	L:L:?1	R:R:F327	28.9765	5.72	Yes	No	1	0	7
50	R:R:F327	R:R:L350	28.5028	3.65	No	No	0	7	4
51	R:R:F320	R:R:W324	18.8266	9.02	No	Yes	0	9	8
52	R:R:F223	R:R:W324	11.4959	4.01	Yes	Yes	0	8	8
53	R:R:L313	R:R:Y234	12.6948	2.34	No	Yes	0	8	9
54	R:R:L350	R:R:T330	23.8019	4.42	No	Yes	0	4	5
55	R:R:M346	R:R:T330	14.779	1.51	No	Yes	0	4	5
56	R:R:C341	R:R:M346	11.13	3.24	No	No	0	3	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D134	23.92	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V135	19.25	1	Yes	No	0	6	0	1
L:L:?1	R:R:S138	15.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:F327	5.72	1	Yes	No	0	7	0	1
L:L:?1	R:R:V354	3.5	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y358	4.13	1	Yes	Yes	0	8	0	1
R:R:D134	R:R:V106	11.69	1	Yes	No	8	7	1	2
R:R:V106	R:R:Y358	5.05	1	No	Yes	7	8	2	1
R:R:D134	R:R:W130	3.35	1	Yes	No	8	5	1	2
R:R:D134	R:R:Y358	10.34	1	Yes	Yes	8	8	1	1
R:R:V135	R:R:V185	3.21	0	No	No	6	6	1	2
R:R:S186	R:R:V135	3.23	0	No	No	8	6	2	1
R:R:F327	R:R:L350	3.65	1	No	No	7	4	1	2
R:R:F327	R:R:V354	7.87	1	No	No	7	7	1	1
R:R:V354	R:R:Y358	5.05	1	No	Yes	7	8	1	1
R:R:W355	R:R:Y358	9.65	1	Yes	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DPH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	250
Number of Links	262
Number of Hubs	30
Number of Links mediated by Hubs	114
Number of Communities	10
Number of Nodes involved in Communities	45
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	43236
Length Of Smallest Path	3
Average Path Length	16.9861
Length of Longest Path	38
Minimum Path Strength	1.3
Average Path Strength	6.19634
Maximum Path Strength	21.585
Minimum Path Correlation	0.7
Average Path Correlation	0.914341
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	38.6984
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8601
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • Gq/11-coupled serotonin receptor activity • identical protein binding • protein binding • behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • system process • nervous system process • regulation of system process • regulation of multicellular organismal process • regulation of nervous system process • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • corticotropin-releasing hormone secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of corticotropin-releasing hormone secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • hormone transport • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of lipid metabolic process • glycerophospholipid metabolic process • lipid biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • phospholipid metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of lipid metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • regulation of phosphatidylinositol biosynthetic process • regulation of biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • primary metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • biosynthetic process • positive regulation of lipid biosynthetic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • metabolic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • cGMP-mediated signaling • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • feeding behavior • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cellular localization • monoatomic ion transmembrane transport • negative regulation of biological process • negative regulation of sequestering of calcium ion • calcium ion transport • metal ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • negative regulation of cellular process • monoatomic ion transport • monoatomic cation transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • response to nutrient levels • regulation of appetite • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • developmental process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse
Gene Ontology	Cellular Component	• protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	T4U
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	T4U
Name	Lorcaserin
Synonyms	Lorcaserin
Identifier
Formula	C11 H14 Cl N
Molecular Weight	195.689
SMILES
PubChem	11658860
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28335
Sequence	>8DPH_nogp_Chain_R S I V I I I I M T I G G N I L V I M A V S M E K K L H N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D Y V W L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A V R S P V E H S R F N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D E E K V F V N T C V L N D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C E C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I Y R R A F S N Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZMF	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	A1L10	-	-	3.6	2024-08-28	10.1021/acs.jmedchem.4c01244
	8DPI	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.4	2022-08-24	10.1016/j.celrep.2022.111211
	8DPI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-		3.4	2022-08-24	10.1016/j.celrep.2022.111211
	8DPH	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.2	2022-08-24	10.1016/j.celrep.2022.111211
	8DPH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-		3.2	2022-08-24	10.1016/j.celrep.2022.111211
	8DPG	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Psilocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.6	2022-08-24	10.1016/j.celrep.2022.111211
	8DPG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Psilocin	-		3.6	2022-08-24	10.1016/j.celrep.2022.111211
	8DPF	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.84	2022-08-24	10.1016/j.celrep.2022.111211
	8DPF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Lorcaserin	-		2.84	2022-08-24	10.1016/j.celrep.2022.111211
	6BQH	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Ritanserin	-	-	2.7	2018-02-14	10.1016/j.cell.2018.01.001
	6BQG	A	Amine	5-Hydroxytryptamine	5-HT_2C	Homo sapiens	Ergotamine	-	-	3	2018-02-14	10.1016/j.cell.2018.01.001

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Download 8DPH_nogp.zip

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