psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q67	R:R:T64	8.5	No	No	0	7	4
2	R:R:Q67	R:R:W66	3.29	No	No	0	7	4
3	R:R:F70	R:R:F73	3.22	No	No	0	4	5
4	R:R:F73	R:R:I77	10.05	No	No	0	5	4
5	R:R:T126	R:R:T75	7.85	No	No	0	9	8
6	R:R:T75	R:R:W531	6.06	No	Yes	0	8	8
7	R:R:T538	R:R:T82	9.42	No	No	0	8	9
8	R:R:I83	R:R:V119	3.07	No	No	0	8	6
9	R:R:A111	R:R:N86	4.69	No	No	0	9	9
10	R:R:D114	R:R:N86	4.04	No	No	0	9	9
11	R:R:N86	R:R:P541	4.89	No	No	0	9	9
12	R:R:F555	R:R:L88	12.18	Yes	No	0	9	8
13	R:R:A111	R:R:V89	3.39	No	No	0	9	9
14	R:R:F555	R:R:V89	5.24	Yes	No	0	9	9
15	R:R:S92	R:R:T554	6.4	Yes	No	0	9	9
16	R:R:F555	R:R:S92	3.96	Yes	Yes	0	9	9
17	R:R:F93	R:R:K94	7.44	Yes	No	0	9	6
18	R:R:F93	R:R:K100	4.96	Yes	No	0	9	8
19	R:R:F93	R:R:Y105	5.16	Yes	No	0	9	8
20	R:R:F93	R:R:L108	8.53	Yes	No	0	9	8
21	R:R:L99	R:R:N96	9.61	Yes	No	4	9	8
22	R:R:N96	R:R:T550	4.39	No	Yes	4	8	8
23	R:R:N96	R:R:T554	8.77	No	No	0	8	9
24	R:R:K100	R:R:K97	10.06	No	No	0	8	8
25	R:R:L99	R:R:Q98	3.99	Yes	No	4	9	8
26	R:R:Q98	R:R:T550	11.34	No	Yes	4	8	8
27	R:R:L99	R:R:N104	5.49	Yes	Yes	4	9	9
28	R:R:L99	R:R:T550	7.37	Yes	Yes	4	9	8
29	R:R:F551	R:R:L99	18.27	No	Yes	4	9	9
30	R:R:N104	R:R:T101	7.31	Yes	No	0	9	8
31	R:R:R180	R:R:V102	9.15	Yes	No	0	9	8
32	R:R:N103	R:R:N104	4.09	No	Yes	0	9	9
33	R:R:D165	R:R:N103	4.04	Yes	No	0	9	9
34	R:R:N103	R:R:R177	8.44	No	No	0	9	8
35	R:R:F551	R:R:N104	7.25	No	Yes	4	9	9
36	R:R:F106	R:R:I162	3.77	Yes	Yes	2	8	9
37	R:R:D165	R:R:F106	5.97	Yes	Yes	2	9	8
38	R:R:F106	R:R:R180	4.28	Yes	Yes	2	8	9
39	R:R:F106	R:R:I189	3.77	Yes	No	0	8	9
40	R:R:A545	R:R:L107	3.15	No	No	0	9	9
41	R:R:N158	R:R:S109	5.96	No	No	0	9	9
42	R:R:I189	R:R:S109	7.74	No	No	0	9	9
43	R:R:L110	R:R:L159	5.54	No	No	0	9	9
44	R:R:L110	R:R:N540	10.98	No	Yes	0	9	9
45	R:R:D114	R:R:S537	11.78	No	No	0	9	9
46	R:R:D114	R:R:N540	8.08	No	Yes	0	9	9
47	R:R:I116	R:R:I120	4.42	No	No	0	8	6
48	R:R:A151	R:R:I116	3.25	No	No	0	8	8
49	R:R:I117	R:R:S121	3.1	Yes	No	0	9	9
50	R:R:A151	R:R:I117	3.25	No	Yes	0	8	9
51	R:R:I117	R:R:Y534	7.25	Yes	Yes	0	9	9
52	R:R:I117	R:R:S537	7.74	Yes	No	0	9	9
53	R:R:I120	R:R:V119	3.07	No	No	0	6	6
54	R:R:I120	R:R:I147	4.42	No	No	0	6	6
55	R:R:S121	R:R:W144	4.94	No	Yes	0	9	8
56	R:R:D148	R:R:S121	8.83	Yes	No	0	9	9
57	R:R:M122	R:R:W531	10.47	No	Yes	0	9	8
58	R:R:L124	R:R:W134	3.42	No	Yes	1	8	9
59	R:R:L124	R:R:W144	6.83	No	Yes	1	8	8
60	R:R:F125	R:R:Y128	3.09	Yes	No	0	8	8
61	R:R:F125	R:R:W144	6.01	Yes	Yes	1	8	8
62	R:R:F125	R:R:Y530	11.35	Yes	Yes	1	8	7
63	R:R:F125	R:R:Y534	3.09	Yes	Yes	1	8	9
64	R:R:W134	R:R:Y128	6.75	Yes	No	0	9	8
65	R:R:E220	R:R:Y128	4.49	No	No	0	4	8
66	R:R:M131	R:R:R133	3.72	No	No	0	7	5
67	R:R:L136	R:R:W134	10.25	No	Yes	0	8	9
68	R:R:C141	R:R:W134	11.75	No	Yes	0	9	9
69	R:R:W134	R:R:W144	13.12	Yes	Yes	1	9	8
70	R:R:N138	R:R:R214	8.44	No	Yes	0	5	7
71	R:R:C141	R:R:C221	7.28	No	No	0	9	9
72	R:R:D142	R:R:I204	7	Yes	Yes	3	8	8
73	R:R:D142	R:R:L205	6.79	Yes	No	3	8	7
74	R:R:D142	R:R:Q208	3.92	Yes	No	3	8	7
75	R:R:D142	R:R:R214	4.76	Yes	Yes	3	8	7
76	R:R:L145	R:R:W144	3.42	No	Yes	0	8	8
77	R:R:I204	R:R:L145	4.28	Yes	No	0	8	8
78	R:R:D148	R:R:S152	4.42	Yes	No	1	9	9
79	R:R:D148	R:R:Y530	3.45	Yes	Yes	1	9	7
80	R:R:D148	R:R:Y534	13.79	Yes	Yes	1	9	9
81	L:L:?1	R:R:D148	12.55	Yes	Yes	1	0	9
82	R:R:C149	R:R:W200	11.75	No	Yes	1	9	9
83	L:L:?1	R:R:C149	5.24	Yes	No	1	0	9
84	L:L:?1	R:R:S152	6.94	Yes	No	1	0	9
85	R:R:N153	R:R:S196	8.94	No	No	0	9	9
86	R:R:N153	R:R:W200	7.91	No	Yes	1	9	9
87	L:L:?1	R:R:N153	6.35	Yes	No	1	0	9
88	R:R:A154	R:R:W193	9.08	No	No	0	9	9
89	R:R:A154	R:R:S196	3.42	No	No	0	9	9
90	R:R:N540	R:R:S155	4.47	Yes	No	0	9	9
91	R:R:P243	R:R:V156	3.53	No	No	0	9	9
92	R:R:F500	R:R:V156	10.49	Yes	No	1	9	9
93	R:R:V156	R:R:W504	4.9	No	Yes	1	9	9
94	R:R:M157	R:R:S196	3.07	No	No	0	8	9
95	R:R:L159	R:R:M247	4.24	No	No	0	9	9
96	R:R:L159	R:R:Y544	12.89	No	Yes	0	9	9
97	R:R:F164	R:R:L160	3.65	No	No	5	8	8
98	R:R:L160	R:R:P243	6.57	No	No	0	8	9
99	R:R:I246	R:R:L160	5.71	No	No	5	8	8
100	R:R:I162	R:R:R166	5.01	Yes	No	2	9	9
101	R:R:I162	R:R:Y544	4.84	Yes	Yes	2	9	9
102	R:R:M247	R:R:S163	3.07	No	No	0	9	9
103	R:R:S163	R:R:Y251	3.82	No	Yes	0	9	9
104	R:R:F164	R:R:I246	3.77	No	No	5	8	8
105	R:R:F164	R:R:L250	10.96	No	No	0	8	8
106	R:R:D165	R:R:Y176	8.05	Yes	Yes	2	9	9
107	R:R:D165	R:R:R180	13.1	Yes	Yes	2	9	9
108	R:R:R166	R:R:Y251	3.09	No	Yes	2	9	9
109	R:R:R166	R:R:Y544	5.14	No	Yes	2	9	9
110	R:R:F168	R:R:Y167	6.19	No	Yes	0	7	9
111	R:R:T171	R:R:Y167	13.73	No	Yes	0	8	9
112	R:R:L250	R:R:Y167	4.69	No	Yes	0	8	9
113	R:R:R253	R:R:Y167	6.17	No	Yes	0	8	9
114	R:R:I254	R:R:Y167	3.63	No	Yes	0	9	9
115	R:R:F168	R:R:Y176	14.44	No	Yes	0	7	9
116	R:R:S169	R:R:Y176	3.82	No	Yes	0	9	9
117	R:R:R177	R:R:S169	11.86	No	No	0	8	9
118	R:R:E257	R:R:I170	9.56	No	No	0	8	8
119	R:R:R172	R:R:T171	9.06	No	No	0	8	8
120	R:R:E257	R:R:T171	7.06	No	No	0	8	8
121	R:R:R172	R:R:T175	3.88	No	No	0	8	7
122	R:R:R180	R:R:Y176	14.4	Yes	Yes	2	9	9
123	R:R:R177	R:R:R180	4.26	No	Yes	0	8	9
124	R:R:K179	R:R:R184	4.95	No	No	0	7	8
125	R:R:K183	R:R:T181	7.51	No	No	0	5	9
126	R:R:I195	R:R:L191	7.14	No	No	0	6	5
127	R:R:P202	R:R:V198	3.53	No	No	0	9	6
128	R:R:L199	R:R:W200	6.83	No	Yes	0	8	9
129	R:R:T235	R:R:W200	8.49	No	Yes	0	9	9
130	L:L:?1	R:R:W200	30.1	Yes	Yes	1	0	9
131	R:R:A203	R:R:F225	4.16	No	Yes	0	7	9
132	R:R:I204	R:R:L205	4.28	Yes	No	3	8	7
133	R:R:F206	R:R:Y209	3.09	No	No	0	7	5
134	R:R:F225	R:R:W207	5.01	Yes	No	0	9	6
135	R:R:E228	R:R:W207	7.63	No	No	0	8	6
136	R:R:Q208	R:R:R214	17.52	No	Yes	3	7	7
137	R:R:Q208	R:R:Q224	8.96	No	Yes	3	7	8
138	R:R:F210	R:R:V211	5.24	No	No	0	6	6
139	R:R:R214	R:R:V216	7.85	Yes	No	3	7	7
140	R:R:Q224	R:R:R214	9.35	Yes	Yes	3	8	7
141	R:R:F222	R:R:V216	11.8	No	No	0	4	7
142	R:R:Q224	R:R:V216	5.73	Yes	No	3	8	7
143	R:R:E220	R:R:P217	4.72	No	No	0	4	4
144	R:R:F225	R:R:I223	10.05	Yes	No	0	9	8
145	R:R:I223	R:R:L226	4.28	No	No	0	8	7
146	R:R:F225	R:R:I231	3.77	Yes	No	0	9	8
147	R:R:P229	R:R:T515	5.25	No	Yes	0	6	8
148	R:R:T232	R:R:T515	4.71	No	Yes	0	8	8
149	R:R:F233	R:R:L512	17.05	No	No	0	8	7
150	R:R:F233	R:R:T515	10.38	No	Yes	0	8	8
151	R:R:I237	R:R:Y241	3.63	No	No	0	7	8
152	R:R:F240	R:R:Y241	11.35	Yes	No	0	9	8
153	R:R:F240	R:R:V244	5.24	Yes	No	0	9	8
154	R:R:F240	R:R:F500	5.36	Yes	Yes	1	9	9
155	R:R:F240	R:R:W504	7.02	Yes	Yes	1	9	9
156	R:R:F240	R:R:N508	18.12	Yes	Yes	1	9	9
157	R:R:M242	R:R:P243	3.35	No	No	0	7	9
158	R:R:L493	R:R:Y251	3.52	No	Yes	0	9	9
159	R:R:I496	R:R:Y251	4.84	Yes	Yes	2	9	9
160	R:R:L497	R:R:Y251	3.52	No	Yes	0	9	9
161	R:R:Y251	R:R:Y544	4.96	Yes	Yes	2	9	9
162	R:R:K256	R:R:W252	5.8	No	No	0	5	7
163	R:R:E259	R:R:Y255	12.35	Yes	No	0	7	7
164	R:R:E259	R:R:E486	11.42	Yes	No	0	7	9
165	R:R:L265	R:R:R261	6.07	No	No	0	6	8
166	R:R:E486	R:R:K487	14.85	No	No	0	9	7
167	R:R:Q491	R:R:T492	4.25	No	Yes	0	8	9
168	R:R:C543	R:R:I496	4.91	No	Yes	0	9	9
169	R:R:I496	R:R:Y544	7.25	Yes	Yes	2	9	9
170	R:R:F500	R:R:W504	7.02	Yes	Yes	1	9	9
171	R:R:F500	R:R:N536	6.04	Yes	Yes	1	9	9
172	R:R:I501	R:R:T505	6.08	No	Yes	0	8	8
173	R:R:T503	R:R:W504	6.06	No	Yes	1	9	9
174	R:R:N536	R:R:T503	7.31	Yes	No	1	9	9
175	R:R:N508	R:R:W504	4.52	Yes	Yes	1	9	9
176	R:R:C533	R:R:W504	13.06	No	Yes	0	9	9
177	R:R:N536	R:R:W504	4.52	Yes	Yes	1	9	9
178	R:R:P506	R:R:T505	3.5	No	Yes	0	9	8
179	R:R:N508	R:R:Y507	6.98	Yes	Yes	1	9	9
180	R:R:V511	R:R:Y507	6.31	No	Yes	1	8	9
181	L:L:?1	R:R:Y507	17.81	Yes	Yes	1	0	9
182	L:L:?1	R:R:N508	5.44	Yes	Yes	1	0	9
183	L:L:?1	R:R:V511	3.94	Yes	No	1	0	8
184	R:R:I521	R:R:V513	3.07	No	No	0	8	7
185	R:R:I521	R:R:N514	4.25	No	No	0	8	7
186	R:R:N514	R:R:W526	5.65	No	No	0	7	6
187	R:R:F516	R:R:T515	5.19	No	Yes	0	7	8
188	R:R:C517	R:R:C520	5.46	No	No	6	8	8
189	R:R:D518	R:R:S519	4.42	No	No	0	3	3
190	R:R:F525	R:R:P522	11.56	No	No	0	6	7
191	R:R:K523	R:R:N527	13.99	No	No	0	3	6
192	R:R:W526	R:R:Y530	3.86	No	Yes	0	6	7
193	R:R:Y530	R:R:Y534	7.94	Yes	Yes	1	7	9
194	L:L:?1	R:R:Y530	13.17	Yes	Yes	1	0	7
195	R:R:W531	R:R:Y534	4.82	Yes	Yes	0	8	9
196	R:R:I535	R:R:W531	7.05	No	Yes	0	7	8
197	L:L:?1	R:R:C533	5.24	Yes	No	0	0	9
198	L:L:?1	R:R:Y534	6.2	Yes	Yes	1	0	9
199	R:R:N536	R:R:N540	12.26	Yes	Yes	0	9	9
200	R:R:L546	R:R:V542	7.45	No	No	0	8	7
201	R:R:F555	R:R:L546	14.61	Yes	No	0	9	8
202	R:R:N548	R:R:T550	5.85	No	Yes	0	9	8
203	R:R:F551	R:R:N548	7.25	No	No	0	9	9
204	R:R:K549	R:R:R552	8.66	No	No	0	7	9
205	R:R:K549	R:R:T553	7.51	No	No	0	7	7
206	R:R:K556	R:R:L559	4.23	No	No	0	7	9
207	R:R:K556	R:R:L560	8.46	No	No	0	7	5
208	R:R:M188	R:R:V161	3.04	No	No	0	8	8
209	R:R:I509	R:R:T505	3.04	No	Yes	0	8	8
210	R:R:L78	R:R:V81	2.98	No	No	0	7	5
211	R:R:L226	R:R:T232	2.95	No	No	0	7	8
212	R:R:L497	R:R:T248	2.95	No	No	0	9	7
213	R:R:I204	R:R:I223	2.94	Yes	No	0	8	8
214	R:R:E228	R:R:S227	2.87	No	No	0	8	5
215	R:R:I84	R:R:L80	2.85	No	No	0	6	7
216	R:R:I83	R:R:L115	2.85	No	No	0	8	8
217	R:R:I90	R:R:L108	2.85	No	No	0	6	8
218	R:R:I162	R:R:L107	2.85	Yes	No	0	9	9
219	R:R:I129	R:R:N527	2.83	No	No	0	8	6
220	R:R:Q224	R:R:T215	2.83	Yes	No	0	8	8
221	R:R:L559	R:R:L88	2.77	No	No	0	9	8
222	R:R:A135	R:R:R133	2.77	No	No	0	7	5
223	R:R:F106	R:R:V161	2.62	Yes	No	0	8	8
224	R:R:A113	R:R:W193	2.59	No	No	0	9	9
225	R:R:F240	R:R:T505	2.59	Yes	Yes	0	9	8
226	R:R:R261	R:R:T262	2.59	No	No	0	8	7
227	R:R:F525	R:R:T524	2.59	No	No	0	6	4
228	R:R:T182	R:R:Y105	2.5	No	No	0	8	8
229	R:R:F206	R:R:L205	2.44	No	No	0	7	7
230	R:R:F93	R:R:N104	2.42	Yes	Yes	0	9	9
231	R:R:M510	R:R:Y507	2.39	No	Yes	0	7	9
232	R:R:L78	R:R:W531	2.28	No	Yes	0	7	8
233	L:L:?1	R:R:G239	2.26	Yes	No	0	0	9
234	L:L:?1	R:R:A236	2.08	Yes	No	0	0	9
235	R:R:G85	R:R:P541	2.03	No	No	0	9	9
236	R:R:A79	R:R:G76	1.95	No	No	0	8	7
237	R:R:A140	R:R:G137	1.95	No	No	0	7	9
238	R:R:A185	R:R:G186	1.95	No	No	0	8	5
239	R:R:P217	R:R:P218	1.95	No	No	0	4	3
240	R:R:A201	R:R:P202	1.87	No	No	0	8	9
241	R:R:G76	R:R:T75	1.82	No	No	0	7	8
242	R:R:G118	R:R:T82	1.82	No	No	0	8	9
243	R:R:G85	R:R:I84	1.76	No	No	0	9	6
244	R:R:G190	R:R:I189	1.76	No	No	0	5	9
245	R:R:P229	R:R:T230	1.75	No	No	0	6	5
246	R:R:G529	R:R:M510	1.75	No	No	0	8	7
247	R:R:G137	R:R:L136	1.71	No	No	0	9	8
248	R:R:C517	R:R:V513	1.71	No	No	6	8	7
249	R:R:C520	R:R:V513	1.71	No	No	6	8	7
250	R:R:G529	R:R:L528	1.71	No	No	0	8	6
251	R:R:G529	R:R:L532	1.71	No	No	0	8	9
252	R:R:C543	R:R:V539	1.71	No	No	0	9	7
253	R:R:A185	R:R:V102	1.7	No	No	0	8	8
254	R:R:A192	R:R:V161	1.7	No	No	0	9	8
255	R:R:A499	R:R:V539	1.7	No	No	0	8	7
256	R:R:C547	R:R:T492	1.69	No	Yes	0	9	9
257	R:R:I521	R:R:P522	1.69	No	No	0	8	7
258	R:R:A489	R:R:T258	1.68	No	No	0	9	9
259	R:R:C112	R:R:I90	1.64	No	No	0	7	6
260	R:R:A72	R:R:I130	1.62	No	No	0	8	7
261	R:R:S92	R:R:V91	1.62	Yes	No	0	9	6
262	R:R:A146	R:R:I204	1.62	No	Yes	0	7	8
263	R:R:S537	R:R:T82	1.6	No	No	0	9	9
264	R:R:V91	R:R:V95	1.6	No	No	0	6	8
265	R:R:T64	R:R:V68	1.59	No	No	0	4	7
266	R:R:T126	R:R:T127	1.57	No	No	0	9	7
267	R:R:A79	R:R:N123	1.56	No	No	0	8	9
268	R:R:I77	R:R:V81	1.54	No	No	0	4	5
269	R:R:I87	R:R:V91	1.54	No	No	0	7	6
270	R:R:I147	R:R:V150	1.54	No	No	0	6	9
271	R:R:M188	R:R:V187	1.52	No	No	0	8	5
272	R:R:I249	R:R:T245	1.52	No	No	0	7	7
273	R:R:I249	R:R:T248	1.52	No	No	0	7	7
274	R:R:I254	R:R:T258	1.52	No	No	0	9	9
275	R:R:A495	R:R:Q491	1.52	No	No	0	9	8
276	R:R:I496	R:R:T492	1.52	Yes	Yes	0	9	9
277	R:R:F233	R:R:G234	1.51	No	No	0	8	7
278	R:R:M557	R:R:T553	1.51	No	No	0	6	7
279	R:R:L558	R:R:S92	1.5	No	Yes	0	8	9
280	R:R:G219	R:R:R133	1.5	No	No	0	3	5
281	R:R:K183	R:R:T182	1.5	No	No	0	5	8
282	R:R:K488	R:R:T492	1.5	No	Yes	0	9	9
283	R:R:L498	R:R:S494	1.5	No	No	0	6	9
284	R:R:I129	R:R:I130	1.47	No	No	0	8	7
285	R:R:L174	R:R:T175	1.47	No	No	0	8	7
286	R:R:P173	R:R:R172	1.44	No	No	0	9	8
287	R:R:E259	R:R:T258	1.41	Yes	No	0	7	9
288	R:R:E259	R:R:T262	1.41	Yes	No	0	7	7
289	R:R:A490	R:R:Y255	1.33	No	No	0	9	7
290	R:R:F197	R:R:V150	1.31	No	No	0	5	9
291	R:R:R184	R:R:V187	1.31	No	No	0	8	5
292	R:R:V65	R:R:W66	1.23	No	No	0	4	4
293	R:R:F125	R:R:N527	1.21	Yes	No	0	8	6
294	R:R:L546	R:R:R552	1.21	No	No	0	8	9
295	R:R:K256	R:R:Y255	1.19	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S92	3.37	4	0	9
2	R:R:F93	5.702	5	0	9
3	R:R:L99	8.946	5	4	9
4	R:R:N104	5.312	5	4	9
5	R:R:F106	4.082	5	2	8
6	R:R:I117	5.335	4	0	9
7	R:R:F125	4.95	5	1	8
8	R:R:W134	9.058	5	1	9
9	R:R:D142	5.6175	4	3	8
10	R:R:W144	6.864	5	1	8
11	R:R:D148	8.608	5	1	9
12	R:R:I162	4.1175	4	2	9
13	R:R:D165	7.79	4	2	9
14	R:R:Y167	6.882	5	0	9
15	R:R:Y176	10.1775	4	2	9
16	R:R:R180	9.038	5	2	9
17	R:R:W200	13.016	5	1	9
18	R:R:I204	4.024	5	3	8
19	R:R:R214	9.584	5	3	7
20	R:R:Q224	6.7175	4	3	8
21	R:R:F225	5.7475	4	0	9
22	R:R:F240	8.28	6	1	9
23	R:R:Y251	3.95833	6	2	9
24	R:R:E259	6.6475	4	0	7
25	R:R:T492	2.24	4	0	9
26	R:R:I496	4.63	4	2	9
27	R:R:F500	7.2275	4	1	9
28	R:R:W504	6.72857	7	1	9
29	R:R:T505	3.8025	4	0	8
30	R:R:Y507	8.3725	4	1	9
31	R:R:N508	8.765	4	1	9
32	R:R:T515	6.3825	4	0	8
33	R:R:Y530	7.954	5	1	7
34	R:R:W531	6.136	5	0	8
35	R:R:Y534	7.18167	6	1	9
36	R:R:N536	7.5325	4	1	9
37	R:R:N540	8.9475	4	0	9
38	R:R:Y544	7.016	5	2	9
39	R:R:T550	7.2375	4	4	8
40	R:R:F555	8.9975	4	0	9
41	L:L:?1	9.02462	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L78	R:R:W531	10.3437	2.28	No	Yes	0	7	8
2	R:R:T75	R:R:W531	12.1778	6.06	No	Yes	0	8	8
3	R:R:W531	R:R:Y534	27.9558	4.82	Yes	Yes	0	8	9
4	R:R:I117	R:R:Y534	41.1769	7.25	Yes	Yes	0	9	9
5	R:R:I117	R:R:S537	71.6964	7.74	Yes	No	0	9	9
6	R:R:A151	R:R:I117	18.0349	3.25	No	Yes	0	8	9
7	R:R:A151	R:R:I116	16.0848	3.25	No	No	0	8	8
8	R:R:I116	R:R:I120	14.1211	4.42	No	No	0	8	6
9	R:R:A111	R:R:N86	39.5336	4.69	No	No	0	9	9
10	R:R:D114	R:R:N86	46.7271	4.04	No	No	0	9	9
11	R:R:D114	R:R:S537	73.5238	11.78	No	No	0	9	9
12	R:R:F555	R:R:V89	37.3244	5.24	Yes	No	0	9	9
13	R:R:A111	R:R:V89	38.1222	3.39	No	No	0	9	9
14	R:R:F555	R:R:S92	29.1968	3.96	Yes	Yes	0	9	9
15	R:R:S92	R:R:T554	25.9785	6.4	Yes	No	0	9	9
16	R:R:N96	R:R:T554	25.4671	8.77	No	No	0	8	9
17	R:R:L99	R:R:N96	21.5328	9.61	Yes	No	4	9	8
18	R:R:L99	R:R:N104	20.7078	5.49	Yes	Yes	4	9	9
19	R:R:F93	R:R:N104	28.3036	2.42	Yes	Yes	0	9	9
20	R:R:D114	R:R:N540	56.1162	8.08	No	Yes	0	9	9
21	R:R:L110	R:R:N540	75.3784	10.98	No	Yes	0	9	9
22	R:R:L110	R:R:L159	74.6761	5.54	No	No	0	9	9
23	R:R:L159	R:R:Y544	71.7851	12.89	No	Yes	0	9	9
24	R:R:I162	R:R:Y544	59.2663	4.84	Yes	Yes	2	9	9
25	R:R:F106	R:R:I162	62.4097	3.77	Yes	Yes	2	8	9
26	R:R:D165	R:R:F106	36.588	5.97	Yes	Yes	2	9	8
27	R:R:D165	R:R:N103	34.1879	4.04	Yes	No	0	9	9
28	R:R:N103	R:R:N104	34.2834	4.09	No	Yes	0	9	9
29	R:R:F93	R:R:Y105	10.3505	5.16	Yes	No	0	9	8
30	R:R:F106	R:R:R180	17.694	4.28	Yes	Yes	2	8	9
31	R:R:I117	R:R:S121	34.8766	3.1	Yes	No	0	9	9
32	R:R:D148	R:R:S121	28.699	8.83	Yes	No	0	9	9
33	R:R:F125	R:R:Y534	50.8796	3.09	Yes	Yes	1	8	9
34	R:R:F125	R:R:W144	61.5914	6.01	Yes	Yes	1	8	8
35	R:R:F125	R:R:Y128	20.0805	3.09	Yes	No	0	8	8
36	R:R:W134	R:R:Y128	10.3982	6.75	Yes	No	0	9	8
37	R:R:W134	R:R:W144	20.3259	13.12	Yes	Yes	1	9	8
38	R:R:L136	R:R:W134	14.6802	10.25	No	Yes	0	8	9
39	R:R:L145	R:R:W144	100	3.42	No	Yes	0	8	8
40	R:R:I204	R:R:L145	96.9999	4.28	Yes	No	0	8	8
41	R:R:D142	R:R:I204	32.6538	7	Yes	Yes	3	8	8
42	R:R:D142	R:R:R214	19.6236	4.76	Yes	Yes	3	8	7
43	L:L:?1	R:R:Y534	59.2868	6.2	Yes	Yes	1	0	9
44	L:L:?1	R:R:N153	17.7894	6.35	Yes	No	1	0	9
45	R:R:N153	R:R:S196	14.9939	8.94	No	No	0	9	9
46	L:L:?1	R:R:N508	71.526	5.44	Yes	Yes	1	0	9
47	R:R:N508	R:R:W504	63.2483	4.52	Yes	Yes	1	9	9
48	R:R:V156	R:R:W504	91.7837	4.9	No	Yes	1	9	9
49	R:R:P243	R:R:V156	94.5793	3.53	No	No	0	9	9
50	L:L:?1	R:R:C533	58.7413	5.24	Yes	No	0	0	9
51	R:R:C533	R:R:W504	58.2163	13.06	No	Yes	0	9	9
52	R:R:F240	R:R:N508	13.1597	18.12	Yes	Yes	1	9	9
53	R:R:F164	R:R:L160	81.3037	3.65	No	No	5	8	8
54	R:R:L160	R:R:P243	88.1699	6.57	No	No	0	8	9
55	R:R:Y251	R:R:Y544	13.2074	4.96	Yes	Yes	2	9	9
56	R:R:F164	R:R:L250	80.1582	10.96	No	No	0	8	8
57	R:R:D165	R:R:Y176	16.8485	8.05	Yes	Yes	2	9	9
58	R:R:R180	R:R:Y176	10.4323	14.4	Yes	Yes	2	9	9
59	R:R:L250	R:R:Y167	77.9626	4.69	No	Yes	0	8	9
60	R:R:F168	R:R:Y167	27.9422	6.19	No	Yes	0	7	9
61	R:R:F168	R:R:Y176	25.9785	14.44	No	Yes	0	7	9
62	R:R:T171	R:R:Y167	28.8695	13.73	No	Yes	0	8	9
63	R:R:I254	R:R:Y167	53.0751	3.63	No	Yes	0	9	9
64	R:R:R172	R:R:T171	16.903	9.06	No	No	0	8	8
65	R:R:F106	R:R:V161	13.0847	2.62	Yes	No	0	8	8
66	R:R:F225	R:R:I223	19.7532	10.05	Yes	No	0	9	8
67	R:R:I204	R:R:I223	51.4796	2.94	Yes	No	0	8	8
68	R:R:F225	R:R:W207	10.1186	5.01	Yes	No	0	9	6
69	R:R:I223	R:R:L226	29.6332	4.28	No	No	0	8	7
70	R:R:L226	R:R:T232	26.7217	2.95	No	No	0	7	8
71	R:R:T232	R:R:T515	23.4283	4.71	No	Yes	0	8	8
72	R:R:F233	R:R:T515	10.1186	10.38	No	Yes	0	8	8
73	R:R:I496	R:R:Y544	19.0304	7.25	Yes	Yes	2	9	9
74	R:R:L497	R:R:Y251	11.5505	3.52	No	Yes	0	9	9
75	R:R:I254	R:R:T258	48.9909	1.52	No	No	0	9	9
76	R:R:E259	R:R:T258	41.3132	1.41	Yes	No	0	7	9
77	R:R:E259	R:R:Y255	16.903	12.35	Yes	No	0	7	7
78	R:R:E259	R:R:T262	12.696	1.41	Yes	No	0	7	7
79	R:R:I496	R:R:T492	10.9232	1.52	Yes	Yes	0	9	9
80	R:R:N536	R:R:W504	37.9381	4.52	Yes	Yes	1	9	9
81	R:R:F240	R:R:T505	13.112	2.59	Yes	Yes	0	9	8
82	R:R:W526	R:R:Y530	24.7307	3.86	No	Yes	0	6	7
83	R:R:N514	R:R:W526	22.0033	5.65	No	No	0	7	6
84	R:R:I521	R:R:N514	19.5623	4.25	No	No	0	8	7
85	R:R:F125	R:R:N527	13.4392	1.21	Yes	No	0	8	6
86	R:R:F555	R:R:L546	10.9982	14.61	Yes	No	0	9	8
87	R:R:M510	R:R:Y507	10.33	2.39	No	Yes	0	7	9
88	R:R:S121	R:R:W144	59.9073	4.94	No	Yes	0	9	8
89	R:R:F500	R:R:N536	10.3709	6.04	Yes	Yes	1	9	9
90	R:R:N536	R:R:N540	46.8703	12.26	Yes	Yes	0	9	9
91	L:L:?1	R:R:D148	28.324	12.55	Yes	Yes	1	0	9
92	L:L:?1	R:R:Y530	51.7728	13.17	Yes	Yes	1	0	7
93	R:R:F125	R:R:Y530	40.9655	11.35	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I117	R:R:S121	3.1	0	Yes	No	9	9	2	2
R:R:I117	R:R:Y534	7.25	0	Yes	Yes	9	9	2	1
R:R:D148	R:R:S121	8.83	1	Yes	No	9	9	1	2
R:R:F125	R:R:Y530	11.35	1	Yes	Yes	8	7	2	1
R:R:F125	R:R:Y534	3.09	1	Yes	Yes	8	9	2	1
R:R:D148	R:R:S152	4.42	1	Yes	No	9	9	1	1
R:R:D148	R:R:Y530	3.45	1	Yes	Yes	9	7	1	1
R:R:D148	R:R:Y534	13.79	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:D148	12.55	1	Yes	Yes	0	9	0	1
R:R:C149	R:R:W200	11.75	1	No	Yes	9	9	1	1
L:L:?1	R:R:C149	5.24	1	Yes	No	0	9	0	1
L:L:?1	R:R:S152	6.94	1	Yes	No	0	9	0	1
R:R:N153	R:R:S196	8.94	1	No	No	9	9	1	2
R:R:N153	R:R:W200	7.91	1	No	Yes	9	9	1	1
L:L:?1	R:R:N153	6.35	1	Yes	No	0	9	0	1
R:R:L199	R:R:W200	6.83	0	No	Yes	8	9	2	1
R:R:T235	R:R:W200	8.49	0	No	Yes	9	9	2	1
L:L:?1	R:R:W200	30.1	1	Yes	Yes	0	9	0	1
R:R:F240	R:R:W504	7.02	1	Yes	Yes	9	9	2	2
R:R:F240	R:R:N508	18.12	1	Yes	Yes	9	9	2	1
R:R:N508	R:R:W504	4.52	1	Yes	Yes	9	9	1	2
R:R:C533	R:R:W504	13.06	0	No	Yes	9	9	1	2
R:R:N508	R:R:Y507	6.98	1	Yes	Yes	9	9	1	1
R:R:V511	R:R:Y507	6.31	1	No	Yes	8	9	1	1
L:L:?1	R:R:Y507	17.81	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N508	5.44	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:V511	3.94	1	Yes	No	0	8	0	1
R:R:W526	R:R:Y530	3.86	0	No	Yes	6	7	2	1
R:R:Y530	R:R:Y534	7.94	1	Yes	Yes	7	9	1	1
L:L:?1	R:R:Y530	13.17	1	Yes	Yes	0	7	0	1
R:R:W531	R:R:Y534	4.82	0	Yes	Yes	8	9	2	1
L:L:?1	R:R:C533	5.24	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y534	6.2	1	Yes	Yes	0	9	0	1
R:R:M510	R:R:Y507	2.39	0	No	Yes	7	9	2	1
L:L:?1	R:R:G239	2.26	1	Yes	No	0	9	0	1
L:L:?1	R:R:A236	2.08	1	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E9W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	263
Number of Links	295
Number of Hubs	41
Number of Links mediated by Hubs	155
Number of Communities	6
Number of Nodes involved in Communities	49
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	51231
Length Of Smallest Path	3
Average Path Length	13.0273
Length of Longest Path	27
Minimum Path Strength	1.26
Average Path Strength	6.2005
Maximum Path Strength	23.955
Minimum Path Correlation	0.7
Average Path Correlation	0.923129
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.3859
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9548
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • hydrolase activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • catalytic activity • phospholipase activity • lipase activity • cation binding • acetylcholine binding • ion binding • binding • small molecule binding • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • macromolecule modification • metabolic process • primary metabolic process • protein metabolic process • macromolecule metabolic process • protein modification process • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • multicellular organismal process • regulation of body fluid levels • system process • secretion by tissue • digestive system process • secretion • transport • establishment of localization • body fluid secretion • localization • digestion • saliva secretion • regulation of biological quality • smooth muscle contraction • muscle contraction • muscle system process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • regulation of system process • regulation of muscle system process • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of multicellular organismal process • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • positive regulation of smooth muscle contraction • positive regulation of biological process • positive regulation of muscle contraction • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • positive regulation of protein secretion • peptide transport • positive regulation of transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • ligand-gated ion channel signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • endoplasmic reticulum subcompartment • intracellular organelle • organelle • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • cytoplasm • organelle membrane • endoplasmic reticulum membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WEC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WEC
Name	11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Synonyms
Identifier
Formula	C18 H20 N4
Molecular Weight	292.378
SMILES
PubChem	16103
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	0
Total Bonds	45
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20309
Sequence	>8E9W_nogp_Chain_R T V W Q V V F I A F L T G I L A L V T I I G N I L V I V S F K V N K Q L K T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M N R W A L G N L A C D L W L A I D C V A S N A S V M N L L V I S F D R Y F S I T R P L T Y R A K R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G K R T V P P G E C F I Q F L S E P T I T F G T A I A G F Y M P V T I M T I L Y W R I Y K E T E K R T K E L E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C D S C I P K T F W N L G Y W L C Y I N S T V N P V C Y A L C N K T F R T T F K M L L L C Q C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4U14	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	3.57	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4U15	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	2.8	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4U16	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	N-Methyl-Scopolamine	-	-	3.7	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4DAJ	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	3.4	2012-02-22	doi.org/10.1038/nature10867
	8E9W	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	2-Deoxycytidine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9W (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	2-Deoxycytidine	-		2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Y	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Clozapine-N-oxide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.79	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Y (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Clozapine-N-oxide	-		2.79	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Z	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Z (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-		2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8EA0	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-	-	2.56	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	5ZHP	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	PubChem 134828589	-	-	3.1	2018-11-28	doi.org/10.1073/pnas.1813988115
	7M3J	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3E	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6

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