psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F70	R:R:L74	12.18	No	No	0	4	5
2	R:R:F73	R:R:I77	5.02	No	No	0	5	4
3	R:R:T126	R:R:T75	6.28	No	No	0	9	8
4	R:R:T75	R:R:W531	8.49	No	Yes	0	8	8
5	R:R:L78	R:R:W531	7.97	No	Yes	5	7	8
6	R:R:I535	R:R:L78	5.71	No	No	5	7	7
7	R:R:L78	R:R:T538	5.9	No	No	0	7	8
8	R:R:M122	R:R:T82	7.53	No	No	0	9	9
9	R:R:T538	R:R:T82	9.42	No	No	0	8	9
10	R:R:D114	R:R:N86	10.77	No	No	0	9	9
11	R:R:L115	R:R:N86	4.12	No	No	0	8	9
12	R:R:S92	R:R:T554	6.4	No	No	0	9	9
13	R:R:F555	R:R:S92	5.28	Yes	No	0	9	9
14	R:R:F93	R:R:K100	4.96	Yes	No	0	9	8
15	R:R:F93	R:R:Y105	4.13	Yes	No	0	9	8
16	R:R:F93	R:R:L108	7.31	Yes	No	0	9	8
17	R:R:N96	R:R:Q98	9.24	No	No	0	8	8
18	R:R:L99	R:R:N96	12.36	Yes	No	0	9	8
19	R:R:N96	R:R:T554	11.7	No	No	0	8	9
20	R:R:L99	R:R:N104	4.12	Yes	Yes	3	9	9
21	R:R:L99	R:R:T550	5.9	Yes	No	0	9	8
22	R:R:F551	R:R:L99	17.05	Yes	Yes	3	9	9
23	R:R:N103	R:R:T101	7.31	Yes	No	3	9	8
24	R:R:N104	R:R:T101	10.24	Yes	No	3	9	8
25	R:R:R180	R:R:V102	13.08	Yes	No	0	9	8
26	R:R:N103	R:R:N104	4.09	Yes	Yes	3	9	9
27	R:R:N103	R:R:R177	10.85	Yes	No	3	9	8
28	R:R:N103	R:R:R180	4.82	Yes	Yes	3	9	9
29	R:R:L107	R:R:N104	4.12	No	Yes	0	9	9
30	R:R:F551	R:R:N104	9.67	Yes	Yes	3	9	9
31	R:R:T182	R:R:Y105	6.24	No	No	0	8	8
32	R:R:F106	R:R:V161	6.55	Yes	No	6	8	8
33	R:R:D165	R:R:F106	9.55	No	Yes	0	9	8
34	R:R:F106	R:R:M188	6.22	Yes	No	6	8	8
35	R:R:F106	R:R:I189	6.28	Yes	Yes	0	8	9
36	R:R:N158	R:R:S109	10.43	No	No	7	9	9
37	R:R:I189	R:R:S109	6.19	Yes	No	0	9	9
38	R:R:S109	R:R:W193	6.18	No	Yes	7	9	9
39	R:R:L110	R:R:N158	5.49	Yes	No	0	9	9
40	R:R:L110	R:R:L159	4.15	Yes	No	0	9	9
41	R:R:L110	R:R:N540	6.87	Yes	No	0	9	9
42	R:R:A113	R:R:W193	3.89	No	Yes	0	9	9
43	R:R:D114	R:R:S537	10.31	No	No	0	9	9
44	R:R:D114	R:R:N540	10.77	No	No	0	9	9
45	R:R:I117	R:R:S121	7.74	Yes	No	1	9	9
46	R:R:I117	R:R:Y534	4.84	Yes	Yes	1	9	9
47	R:R:I117	R:R:S537	6.19	Yes	No	0	9	9
48	R:R:G118	R:R:M122	5.24	No	No	0	8	9
49	R:R:I120	R:R:V119	4.61	No	No	0	6	6
50	R:R:D148	R:R:S121	8.83	No	No	1	9	9
51	R:R:S121	R:R:Y534	6.36	No	Yes	1	9	9
52	R:R:M122	R:R:Y534	7.18	No	Yes	0	9	9
53	R:R:L124	R:R:N123	6.87	No	No	0	8	9
54	R:R:L124	R:R:W134	5.69	No	Yes	2	8	9
55	R:R:L124	R:R:W144	7.97	No	Yes	2	8	8
56	R:R:F125	R:R:Y530	4.13	No	Yes	0	8	7
57	R:R:F125	R:R:W531	6.01	No	Yes	0	8	8
58	R:R:R133	R:R:Y128	5.14	No	No	0	5	8
59	R:R:W134	R:R:Y128	10.61	Yes	No	0	9	8
60	R:R:N132	R:R:R133	6.03	No	No	0	6	5
61	R:R:E220	R:R:R133	5.82	No	No	0	4	5
62	R:R:L136	R:R:W134	25.06	No	Yes	0	8	9
63	R:R:C141	R:R:W134	5.22	No	Yes	2	9	9
64	R:R:W134	R:R:W144	4.69	Yes	Yes	2	9	8
65	R:R:C221	R:R:W134	15.67	No	Yes	2	9	9
66	R:R:A140	R:R:L136	6.3	No	No	0	7	8
67	R:R:N138	R:R:R214	16.87	No	Yes	0	5	7
68	R:R:D142	R:R:L139	4.07	No	No	0	8	5
69	R:R:C141	R:R:C221	7.28	No	No	2	9	9
70	R:R:D142	R:R:Q208	6.53	No	Yes	0	8	7
71	R:R:L145	R:R:W144	4.56	No	Yes	2	8	8
72	R:R:C221	R:R:W144	3.92	No	Yes	2	9	8
73	R:R:I204	R:R:L145	4.28	No	No	2	8	8
74	R:R:I223	R:R:L145	5.71	Yes	No	2	8	8
75	R:R:A146	R:R:L205	4.73	No	No	0	7	7
76	R:R:D148	R:R:Y534	8.05	No	Yes	1	9	9
77	L:L:?1	R:R:D148	13.76	Yes	No	1	0	9
78	R:R:C149	R:R:W200	13.06	No	Yes	1	9	9
79	L:L:?1	R:R:C149	7.04	Yes	No	1	0	9
80	R:R:F197	R:R:V150	5.24	No	No	0	5	9
81	R:R:S152	R:R:W504	6.18	No	Yes	1	9	9
82	L:L:?1	R:R:S152	6.66	Yes	No	1	0	9
83	R:R:M157	R:R:N153	4.21	No	Yes	0	8	9
84	R:R:N153	R:R:S196	4.47	Yes	No	0	9	9
85	R:R:N153	R:R:W200	7.91	Yes	Yes	1	9	9
86	L:L:?1	R:R:N153	5.22	Yes	Yes	1	0	9
87	R:R:A154	R:R:W193	7.78	No	Yes	0	9	9
88	R:R:F500	R:R:V156	3.93	Yes	No	1	9	9
89	R:R:V156	R:R:W504	4.9	No	Yes	1	9	9
90	R:R:N158	R:R:W193	4.52	No	Yes	7	9	9
91	R:R:L159	R:R:Y544	5.86	No	Yes	0	9	9
92	R:R:L160	R:R:P243	4.93	No	No	0	8	9
93	R:R:M188	R:R:V161	4.56	No	No	6	8	8
94	R:R:I162	R:R:R166	5.01	No	No	4	9	9
95	R:R:I162	R:R:Y544	4.84	No	Yes	4	9	9
96	R:R:L250	R:R:S163	7.51	No	No	0	8	9
97	R:R:S163	R:R:Y251	11.45	No	Yes	0	9	9
98	R:R:F164	R:R:L250	8.53	No	No	0	8	8
99	R:R:D165	R:R:R180	13.1	No	Yes	0	9	9
100	R:R:R166	R:R:Y251	8.23	No	Yes	4	9	9
101	R:R:R166	R:R:Y544	8.23	No	Yes	4	9	9
102	R:R:F168	R:R:Y167	7.22	No	Yes	0	7	9
103	R:R:T171	R:R:Y167	8.74	No	Yes	0	8	9
104	R:R:L250	R:R:Y167	11.72	No	Yes	0	8	9
105	R:R:R253	R:R:Y167	5.14	No	Yes	0	8	9
106	R:R:F168	R:R:Y176	20.63	No	No	0	7	9
107	R:R:R177	R:R:S169	13.18	No	No	0	8	9
108	R:R:E257	R:R:T171	4.23	No	No	0	8	8
109	R:R:K179	R:R:T175	4.5	No	No	0	7	7
110	R:R:R180	R:R:Y176	5.14	Yes	No	0	9	9
111	R:R:R177	R:R:R180	4.26	No	Yes	3	8	9
112	R:R:R184	R:R:T181	18.11	No	No	0	8	9
113	R:R:L199	R:R:W200	7.97	No	Yes	0	8	9
114	R:R:T235	R:R:W200	14.55	No	Yes	0	9	9
115	L:L:?1	R:R:W200	17.32	Yes	Yes	1	0	9
116	R:R:I204	R:R:I223	7.36	No	Yes	2	8	8
117	R:R:F225	R:R:I204	5.02	Yes	No	2	9	8
118	R:R:Q224	R:R:W207	8.76	No	Yes	0	8	6
119	R:R:F225	R:R:W207	10.02	Yes	Yes	0	9	6
120	R:R:E228	R:R:W207	5.45	No	Yes	0	8	6
121	R:R:Q208	R:R:R214	4.67	Yes	Yes	0	7	7
122	R:R:Q208	R:R:Q224	7.68	Yes	No	0	7	8
123	R:R:F210	R:R:V211	5.24	No	No	0	6	6
124	R:R:R214	R:R:V216	7.85	Yes	No	0	7	7
125	R:R:Q224	R:R:T215	7.09	No	No	0	8	8
126	R:R:F222	R:R:V216	13.11	No	No	0	4	7
127	R:R:E220	R:R:P217	12.58	No	No	0	4	4
128	R:R:E220	R:R:F222	8.16	No	No	0	4	4
129	R:R:F225	R:R:I223	7.54	Yes	Yes	2	9	8
130	R:R:I223	R:R:L226	5.71	Yes	No	0	8	7
131	R:R:F225	R:R:I231	7.54	Yes	No	0	9	8
132	R:R:L226	R:R:N514	4.12	No	No	0	7	7
133	R:R:P229	R:R:T515	6.99	No	Yes	0	6	8
134	R:R:T232	R:R:T515	6.28	No	Yes	0	8	8
135	R:R:F233	R:R:L512	18.27	No	No	0	8	7
136	R:R:F233	R:R:T515	5.19	No	Yes	0	8	8
137	R:R:I237	R:R:Y241	6.04	No	Yes	0	7	8
138	R:R:F240	R:R:Y241	5.16	Yes	Yes	0	9	8
139	R:R:F240	R:R:V244	7.87	Yes	No	1	9	8
140	R:R:F240	R:R:F500	7.5	Yes	Yes	1	9	9
141	R:R:F240	R:R:W504	9.02	Yes	Yes	1	9	9
142	R:R:F240	R:R:N508	14.5	Yes	No	0	9	9
143	R:R:L512	R:R:Y241	5.86	No	Yes	0	7	8
144	R:R:F500	R:R:V244	3.93	Yes	No	1	9	8
145	R:R:L497	R:R:T248	5.9	No	No	0	9	7
146	R:R:L493	R:R:Y251	5.86	No	Yes	0	9	9
147	R:R:I496	R:R:Y251	8.46	No	Yes	4	9	9
148	R:R:L497	R:R:Y251	4.69	No	Yes	0	9	9
149	R:R:Y251	R:R:Y544	4.96	Yes	Yes	4	9	9
150	R:R:K256	R:R:W252	10.44	No	No	0	5	7
151	R:R:E259	R:R:Y255	11.22	No	Yes	0	7	7
152	R:R:A489	R:R:Y255	4	No	Yes	0	9	7
153	R:R:E259	R:R:E486	12.69	No	No	0	7	9
154	R:R:E264	R:R:K260	4.05	No	No	0	7	7
155	R:R:R261	R:R:T262	6.47	No	No	0	8	7
156	R:R:E486	R:R:K487	10.8	No	No	0	9	7
157	R:R:I496	R:R:Y544	12.09	No	Yes	4	9	9
158	R:R:F500	R:R:W504	12.03	Yes	Yes	1	9	9
159	R:R:F500	R:R:N536	6.04	Yes	Yes	1	9	9
160	R:R:T503	R:R:W504	6.06	No	Yes	1	9	9
161	R:R:N536	R:R:T503	5.85	Yes	No	1	9	9
162	R:R:C533	R:R:W504	11.75	No	Yes	1	9	9
163	R:R:N536	R:R:W504	6.78	Yes	Yes	1	9	9
164	L:L:?1	R:R:W504	4.33	Yes	Yes	1	0	9
165	R:R:V511	R:R:Y507	8.83	No	No	0	8	9
166	R:R:Y507	R:R:Y530	7.94	No	Yes	1	9	7
167	L:L:?1	R:R:Y507	21.54	Yes	No	1	0	9
168	L:L:?1	R:R:N508	5.22	Yes	No	0	0	9
169	R:R:I521	R:R:M510	4.37	Yes	No	0	8	7
170	R:R:N514	R:R:W526	9.04	No	Yes	0	7	6
171	R:R:F516	R:R:T515	3.89	No	Yes	0	7	8
172	R:R:C517	R:R:C520	7.28	No	No	0	8	8
173	R:R:D518	R:R:S519	7.36	No	No	0	3	3
174	R:R:F525	R:R:P522	13	No	No	0	6	7
175	R:R:F525	R:R:T524	3.89	No	No	0	6	4
176	R:R:N527	R:R:W526	5.65	No	Yes	0	6	6
177	R:R:W526	R:R:Y530	3.86	Yes	Yes	0	6	7
178	R:R:Y530	R:R:Y534	6.95	Yes	Yes	1	7	9
179	L:L:?1	R:R:Y530	13.37	Yes	Yes	1	0	7
180	R:R:I535	R:R:W531	7.05	No	Yes	5	7	8
181	L:L:?1	R:R:C533	4.02	Yes	No	1	0	9
182	L:L:?1	R:R:Y534	4.46	Yes	Yes	1	0	9
183	R:R:N536	R:R:N540	5.45	Yes	No	0	9	9
184	R:R:L546	R:R:V542	4.47	No	No	0	8	7
185	R:R:C543	R:R:Y544	4.03	No	Yes	0	9	9
186	R:R:F555	R:R:L546	15.83	Yes	No	0	9	8
187	R:R:N548	R:R:T550	5.85	No	No	0	9	8
188	R:R:F551	R:R:N548	7.25	Yes	No	0	9	9
189	R:R:K549	R:R:R552	6.19	No	No	0	7	9
190	R:R:F551	R:R:F555	11.79	Yes	Yes	0	9	9
191	R:R:K556	R:R:L560	4.23	No	No	0	7	5
192	R:R:L558	R:R:L559	5.54	No	No	0	8	9
193	R:R:F206	R:R:L205	3.65	No	No	0	7	7
194	R:R:T127	R:R:W134	3.64	No	Yes	0	7	9
195	R:R:I254	R:R:Y167	3.63	No	Yes	0	9	9
196	R:R:M247	R:R:Y251	3.59	No	Yes	0	9	9
197	R:R:P243	R:R:V156	3.53	No	No	0	9	9
198	R:R:G186	R:R:I189	3.53	No	Yes	0	5	9
199	R:R:I521	R:R:W526	3.52	Yes	Yes	0	8	6
200	R:R:P506	R:R:T505	3.5	No	No	0	9	8
201	R:R:K523	R:R:W526	3.48	No	Yes	0	3	6
202	R:R:A111	R:R:V89	3.39	No	No	0	9	9
203	R:R:A545	R:R:V89	3.39	No	No	0	9	9
204	R:R:Q208	R:R:Y209	3.38	Yes	No	0	7	5
205	R:R:L174	R:R:P173	3.28	No	No	0	8	9
206	R:R:N86	R:R:P541	3.26	No	No	0	9	9
207	R:R:A151	R:R:I117	3.25	No	Yes	0	8	9
208	R:R:S196	R:R:V150	3.23	No	No	0	9	9
209	R:R:V65	R:R:V68	3.21	No	No	0	4	7
210	R:R:F206	R:R:Y209	3.09	No	No	0	7	5
211	R:R:I130	R:R:V68	3.07	No	No	0	7	7
212	R:R:I83	R:R:V119	3.07	No	No	0	8	6
213	R:R:I501	R:R:V244	3.07	No	No	0	8	8
214	R:R:M188	R:R:V187	3.04	No	No	0	8	5
215	R:R:I246	R:R:T245	3.04	No	No	0	8	7
216	R:R:I501	R:R:T505	3.04	No	No	0	8	8
217	R:R:I509	R:R:T505	3.04	No	No	0	8	8
218	R:R:M242	R:R:T245	3.01	No	No	0	7	7
219	R:R:L110	R:R:S155	3	Yes	No	0	9	9
220	R:R:K488	R:R:T492	3	No	No	0	9	9
221	R:R:L498	R:R:S494	3	No	No	0	6	9
222	R:R:I83	R:R:I87	2.94	No	No	0	8	7
223	R:R:I116	R:R:I147	2.94	No	No	0	8	6
224	R:R:I120	R:R:I147	2.94	No	No	0	6	6
225	R:R:I237	R:R:M242	2.92	No	No	0	7	7
226	R:R:Q67	R:R:V65	2.87	No	No	0	7	4
227	R:R:E259	R:R:T262	2.82	No	No	0	7	7
228	R:R:L558	R:R:L88	2.77	No	No	0	8	8
229	R:R:E257	R:R:I170	2.73	No	No	0	8	8
230	R:R:E264	R:R:K263	2.7	No	No	0	7	8
231	R:R:A236	R:R:Y241	2.67	No	Yes	0	9	8
232	R:R:A490	R:R:Y255	2.67	No	Yes	0	9	7
233	R:R:F555	R:R:V89	2.62	Yes	No	0	9	9
234	R:R:R261	R:R:T258	2.59	No	No	0	8	9
235	R:R:F125	R:R:I129	2.51	No	No	0	8	8
236	R:R:I249	R:R:R253	2.51	No	No	0	7	8
237	R:R:F93	R:R:K94	2.48	Yes	No	0	9	6
238	R:R:F555	R:R:L88	2.44	Yes	No	0	9	8
239	R:R:I116	R:R:W193	2.35	No	Yes	0	8	9
240	R:R:L493	R:R:Y255	2.34	No	Yes	0	9	7
241	R:R:Q67	R:R:W66	2.19	No	No	0	7	4
242	L:L:?1	R:R:G239	2.17	Yes	No	0	0	9
243	R:R:G85	R:R:P541	2.03	No	No	0	9	9
244	R:R:F210	R:R:W207	2	No	Yes	0	6	6
245	R:R:A79	R:R:G76	1.95	No	No	0	8	7
246	R:R:A140	R:R:G137	1.95	No	No	0	7	9
247	R:R:P217	R:R:P218	1.95	No	No	0	4	3
248	R:R:A201	R:R:P202	1.87	No	No	0	8	9
249	R:R:G76	R:R:T75	1.82	No	No	0	7	8
250	R:R:C561	R:R:C563	1.82	No	No	0	6	4
251	R:R:A499	R:R:C543	1.81	No	No	0	8	9
252	R:R:G85	R:R:I84	1.76	No	No	0	9	6
253	R:R:G190	R:R:I189	1.76	No	Yes	0	5	9
254	R:R:G529	R:R:M510	1.75	No	No	0	8	7
255	R:R:G529	R:R:L528	1.71	No	No	0	8	6
256	R:R:G529	R:R:L532	1.71	No	No	0	8	9
257	R:R:A185	R:R:V102	1.7	No	No	0	8	8
258	R:R:A201	R:R:V150	1.7	No	No	0	8	9
259	R:R:A499	R:R:V539	1.7	No	No	0	8	7
260	R:R:C547	R:R:T492	1.69	No	No	0	9	9
261	R:R:I521	R:R:P522	1.69	Yes	No	0	8	7
262	R:R:C112	R:R:I90	1.64	No	No	0	7	6
263	R:R:A72	R:R:I130	1.62	No	No	0	8	7
264	R:R:A135	R:R:M131	1.61	No	No	0	7	7
265	R:R:A192	R:R:M157	1.61	No	No	0	9	8
266	R:R:V194	R:R:V198	1.6	No	No	0	5	6
267	R:R:T538	R:R:V81	1.59	No	No	0	8	5
268	R:R:A238	R:R:L199	1.58	No	No	0	8	8
269	R:R:T553	R:R:T554	1.57	No	No	0	7	9
270	R:R:C517	R:R:D518	1.56	No	No	0	8	3
271	R:R:I90	R:R:V91	1.54	No	No	0	6	6
272	R:R:I521	R:R:V513	1.54	Yes	No	0	8	7
273	R:R:I496	R:R:T492	1.52	No	No	0	9	9
274	R:R:K183	R:R:T181	1.5	No	No	0	5	9
275	R:R:K263	R:R:T262	1.5	No	No	0	8	7
276	R:R:L80	R:R:V81	1.49	No	No	0	7	5
277	R:R:L191	R:R:V187	1.49	No	No	0	5	5
278	R:R:I129	R:R:I71	1.47	No	No	0	8	8
279	R:R:I87	R:R:I90	1.47	No	No	0	7	6
280	R:R:I129	R:R:I130	1.47	No	No	0	8	7
281	R:R:L174	R:R:T175	1.47	No	No	0	8	7
282	R:R:P173	R:R:R172	1.44	No	No	0	9	8
283	R:R:I195	R:R:N153	1.42	No	Yes	0	6	9
284	R:R:A203	R:R:F225	1.39	No	Yes	0	7	9
285	R:R:L143	R:R:L205	1.38	No	No	0	6	7
286	R:R:E257	R:R:K256	1.35	No	No	0	8	5
287	R:R:A185	R:R:Y105	1.33	No	No	0	8	8
288	R:R:R184	R:R:V187	1.31	No	No	0	8	5
289	R:R:R172	R:R:T171	1.29	No	No	0	8	8
290	R:R:K213	R:R:R214	1.24	No	Yes	0	4	7
291	R:R:L546	R:R:R552	1.21	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F93	4.72	4	0	9
2	R:R:L99	9.8575	4	3	9
3	R:R:N103	6.7675	4	3	9
4	R:R:N104	6.448	5	3	9
5	R:R:F106	7.15	4	6	8
6	R:R:L110	4.8775	4	0	9
7	R:R:I117	5.505	4	1	9
8	R:R:W134	10.0829	7	2	9
9	R:R:W144	5.285	4	2	8
10	R:R:N153	4.646	5	1	9
11	R:R:Y167	7.29	5	0	9
12	R:R:R180	8.08	5	3	9
13	R:R:I189	4.44	4	0	9
14	R:R:W193	4.944	5	7	9
15	R:R:W200	12.162	5	1	9
16	R:R:W207	6.5575	4	0	6
17	R:R:Q208	5.565	4	0	7
18	R:R:R214	7.6575	4	0	7
19	R:R:I223	6.58	4	2	8
20	R:R:F225	6.302	5	2	9
21	R:R:F240	8.81	5	1	9
22	R:R:Y241	4.9325	4	0	8
23	R:R:Y251	6.74857	7	4	9
24	R:R:Y255	5.0575	4	0	7
25	R:R:F500	6.686	5	1	9
26	R:R:W504	7.63125	8	1	9
27	R:R:T515	5.5875	4	0	8
28	R:R:I521	2.78	4	0	8
29	R:R:W526	5.11	5	0	6
30	R:R:Y530	7.25	5	1	7
31	R:R:W531	7.38	4	5	8
32	R:R:Y534	6.30667	6	1	9
33	R:R:N536	6.03	4	1	9
34	R:R:Y544	6.66833	6	4	9
35	R:R:F551	11.44	4	3	9
36	R:R:F555	7.592	5	0	9
37	L:L:?1	8.75917	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M122	R:R:Y534	12.4692	7.18	No	Yes	0	9	9
2	R:R:F125	R:R:Y530	23.0058	4.13	No	Yes	0	8	7
3	R:R:F125	R:R:W531	11.1864	6.01	No	Yes	0	8	8
4	R:R:D114	R:R:S537	10.7383	10.31	No	No	0	9	9
5	R:R:I117	R:R:S537	10.6375	6.19	Yes	No	0	9	9
6	R:R:I117	R:R:Y534	10.3294	4.84	Yes	Yes	1	9	9
7	R:R:F551	R:R:F555	17.1745	11.79	Yes	Yes	0	9	9
8	R:R:F551	R:R:N104	19.3704	9.67	Yes	Yes	3	9	9
9	R:R:N103	R:R:N104	30.4448	4.09	Yes	Yes	3	9	9
10	R:R:N103	R:R:R180	32.8199	4.82	Yes	Yes	3	9	9
11	R:R:D165	R:R:R180	40.6957	13.1	No	Yes	0	9	9
12	R:R:D165	R:R:F106	41.3175	9.55	No	Yes	0	9	8
13	R:R:F106	R:R:I189	48.4315	6.28	Yes	Yes	0	8	9
14	R:R:I189	R:R:S109	50.9019	6.19	Yes	No	0	9	9
15	R:R:N158	R:R:S109	47.4233	10.43	No	No	7	9	9
16	R:R:L110	R:R:N158	62.5084	5.49	Yes	No	0	9	9
17	R:R:L110	R:R:N540	100	6.87	Yes	No	0	9	9
18	R:R:N536	R:R:N540	92.1185	5.45	Yes	No	0	9	9
19	R:R:N536	R:R:W504	76.35	6.78	Yes	Yes	1	9	9
20	L:L:?1	R:R:W504	80.0639	4.33	Yes	Yes	1	0	9
21	L:L:?1	R:R:Y530	73.1347	13.37	Yes	Yes	1	0	7
22	R:R:A185	R:R:V102	10.3126	1.7	No	No	0	8	8
23	R:R:R180	R:R:V102	11.7074	13.08	Yes	No	0	9	8
24	R:R:N158	R:R:W193	14.2449	4.52	No	Yes	7	9	9
25	R:R:L110	R:R:L159	47.7257	4.15	Yes	No	0	9	9
26	R:R:I120	R:R:I147	11.0128	2.94	No	No	0	6	6
27	R:R:I116	R:R:I147	12.542	2.94	No	No	0	8	6
28	R:R:I116	R:R:W193	14.06	2.35	No	Yes	0	8	9
29	R:R:L145	R:R:W144	26.0195	4.56	No	Yes	2	8	8
30	R:R:I223	R:R:L145	25.8851	5.71	Yes	No	2	8	8
31	R:R:I223	R:R:L226	55.3439	5.71	Yes	No	0	8	7
32	R:R:L226	R:R:N514	56.4026	4.12	No	No	0	7	7
33	R:R:N514	R:R:W526	57.3325	9.04	No	Yes	0	7	6
34	R:R:W526	R:R:Y530	69.0679	3.86	Yes	Yes	0	6	7
35	R:R:W134	R:R:W144	18.659	4.69	Yes	Yes	2	9	8
36	R:R:W134	R:R:Y128	10.4974	10.61	Yes	No	0	9	8
37	R:R:Q208	R:R:Q224	19.0119	7.68	Yes	No	0	7	8
38	R:R:Q224	R:R:W207	21.8015	8.76	No	Yes	0	8	6
39	R:R:F225	R:R:W207	27.2126	10.02	Yes	Yes	0	9	6
40	R:R:F225	R:R:I223	29.823	7.54	Yes	Yes	2	9	8
41	L:L:?1	R:R:N153	13.4047	5.22	Yes	Yes	1	0	9
42	R:R:L159	R:R:Y544	46.6726	5.86	No	Yes	0	9	9
43	R:R:L250	R:R:S163	25.4761	7.51	No	No	0	8	9
44	R:R:S163	R:R:Y251	26.3164	11.45	No	Yes	0	9	9
45	R:R:Y251	R:R:Y544	37.9453	4.96	Yes	Yes	4	9	9
46	R:R:F168	R:R:Y167	12.1611	7.22	No	Yes	0	7	9
47	R:R:L250	R:R:Y167	23.8293	11.72	No	Yes	0	8	9
48	R:R:T171	R:R:Y167	15.3204	8.74	No	Yes	0	8	9
49	R:R:R180	R:R:Y176	12.3292	5.14	Yes	No	0	9	9
50	R:R:F233	R:R:T515	10.6151	5.19	No	Yes	0	8	8
51	R:R:F233	R:R:L512	13.2422	18.27	No	No	0	8	7
52	R:R:L512	R:R:Y241	15.6845	5.86	No	Yes	0	7	8
53	R:R:F240	R:R:Y241	31.145	5.16	Yes	Yes	0	9	8
54	R:R:F240	R:R:W504	20.4179	9.02	Yes	Yes	1	9	9
55	R:R:F240	R:R:N508	12.0267	14.5	Yes	No	0	9	9
56	L:L:?1	R:R:N508	11.8754	5.22	Yes	No	0	0	9
57	R:R:I237	R:R:Y241	10.6151	6.04	No	Yes	0	7	8
58	R:R:L493	R:R:Y251	18.8998	5.86	No	Yes	0	9	9
59	R:R:E259	R:R:Y255	13.2198	11.22	No	Yes	0	7	7
60	R:R:L493	R:R:Y255	17.4882	2.34	No	Yes	0	9	7
61	R:R:I521	R:R:W526	13.4551	3.52	Yes	Yes	0	8	6
62	R:R:I501	R:R:V244	10.279	3.07	No	No	0	8	8
63	R:R:F125	R:R:I129	11.4945	2.51	No	No	0	8	8
64	R:R:D114	R:R:N540	12.9565	10.77	No	No	0	9	9
65	R:R:F500	R:R:N536	15.2924	6.04	Yes	Yes	1	9	9
66	R:R:F168	R:R:Y176	11.3209	20.63	No	No	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I117	R:R:S121	7.74	1	Yes	No	9	9	2	2
R:R:I117	R:R:Y534	4.84	1	Yes	Yes	9	9	2	1
R:R:D148	R:R:S121	8.83	1	No	No	9	9	1	2
R:R:S121	R:R:Y534	6.36	1	No	Yes	9	9	2	1
R:R:M122	R:R:Y534	7.18	0	No	Yes	9	9	2	1
R:R:F125	R:R:Y530	4.13	0	No	Yes	8	7	2	1
R:R:D148	R:R:Y534	8.05	1	No	Yes	9	9	1	1
L:L:?1	R:R:D148	13.76	1	Yes	No	0	9	0	1
R:R:C149	R:R:W200	13.06	1	No	Yes	9	9	1	1
L:L:?1	R:R:C149	7.04	1	Yes	No	0	9	0	1
R:R:S152	R:R:W504	6.18	1	No	Yes	9	9	1	1
L:L:?1	R:R:S152	6.66	1	Yes	No	0	9	0	1
R:R:M157	R:R:N153	4.21	0	No	Yes	8	9	2	1
R:R:N153	R:R:S196	4.47	1	Yes	No	9	9	1	2
R:R:N153	R:R:W200	7.91	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:N153	5.22	1	Yes	Yes	0	9	0	1
R:R:F500	R:R:V156	3.93	1	Yes	No	9	9	2	2
R:R:V156	R:R:W504	4.9	1	No	Yes	9	9	2	1
R:R:L199	R:R:W200	7.97	0	No	Yes	8	9	2	1
R:R:T235	R:R:W200	14.55	0	No	Yes	9	9	2	1
L:L:?1	R:R:W200	17.32	1	Yes	Yes	0	9	0	1
R:R:F240	R:R:F500	7.5	1	Yes	Yes	9	9	2	2
R:R:F240	R:R:W504	9.02	1	Yes	Yes	9	9	2	1
R:R:F240	R:R:N508	14.5	1	Yes	No	9	9	2	1
R:R:F500	R:R:W504	12.03	1	Yes	Yes	9	9	2	1
R:R:F500	R:R:N536	6.04	1	Yes	Yes	9	9	2	2
R:R:T503	R:R:W504	6.06	1	No	Yes	9	9	2	1
R:R:N536	R:R:T503	5.85	1	Yes	No	9	9	2	2
R:R:C533	R:R:W504	11.75	1	No	Yes	9	9	1	1
R:R:N536	R:R:W504	6.78	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W504	4.33	1	Yes	Yes	0	9	0	1
R:R:V511	R:R:Y507	8.83	0	No	No	8	9	2	1
R:R:Y507	R:R:Y530	7.94	1	No	Yes	9	7	1	1
L:L:?1	R:R:Y507	21.54	1	Yes	No	0	9	0	1
L:L:?1	R:R:N508	5.22	1	Yes	No	0	9	0	1
R:R:W526	R:R:Y530	3.86	0	Yes	Yes	6	7	2	1
R:R:Y530	R:R:Y534	6.95	1	Yes	Yes	7	9	1	1
L:L:?1	R:R:Y530	13.37	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C533	4.02	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y534	4.46	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G239	2.17	1	Yes	No	0	9	0	1
R:R:I195	R:R:N153	1.42	0	No	Yes	6	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E9Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.86
Number of Linked Nodes	265
Number of Links	291
Number of Hubs	37
Number of Links mediated by Hubs	154
Number of Communities	7
Number of Nodes involved in Communities	49
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	36568
Length Of Smallest Path	3
Average Path Length	13.3473
Length of Longest Path	31
Minimum Path Strength	1.365
Average Path Strength	6.5291
Maximum Path Strength	20.365
Minimum Path Correlation	0.7
Average Path Correlation	0.923872
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	49.451
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.5307
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WE9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WE9
Name	8-chloro-11-(4-methyl-4-oxo-4lambda~5~-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Synonyms
Identifier
Formula	C18 H19 Cl N4 O
Molecular Weight	342.823
SMILES
PubChem	135445691
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	0
Total Bonds	46
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20309
Sequence	>8E9Y_nogp_Chain_R V W Q V V F I A F L T G I L A L V T I I G N I L V I V S F K V N K Q L K T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M N R W A L G N L A C D L W L A I D C V A S N A S V M N L L V I S F D R Y F S I T R P L T Y R A K R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G K R T V P P G E C F I Q F L S E P T I T F G T A I A G F Y M P V T I M T I L Y W R I Y K E T E K R T K E L E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C D S C I P K T F W N L G Y W L C Y I N S T V N P V C Y A L C N K T F R T T F K M L L L C Q C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4U14	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	3.57	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4U15	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	2.8	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4U16	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	N-Methyl-Scopolamine	-	-	3.7	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4DAJ	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	3.4	2012-02-22	doi.org/10.1038/nature10867
	8E9W	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	2-Deoxycytidine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9W (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	2-Deoxycytidine	-		2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Y	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Clozapine-N-oxide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.79	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Y (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Clozapine-N-oxide	-		2.79	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Z	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Z (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-		2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8EA0	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-	-	2.56	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	5ZHP	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	PubChem 134828589	-	-	3.1	2018-11-28	doi.org/10.1073/pnas.1813988115
	7M3J	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3E	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6

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