psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F73	R:R:I77	10.05	No	No	0	5	4
2	R:R:T126	R:R:T75	7.85	No	No	0	9	8
3	R:R:T75	R:R:W531	13.34	No	Yes	0	8	8
4	R:R:L78	R:R:W531	6.83	No	Yes	0	7	8
5	R:R:A79	R:R:M122	4.83	No	No	0	8	9
6	R:R:M122	R:R:T82	6.02	No	No	0	9	9
7	R:R:T538	R:R:T82	7.85	No	No	0	8	9
8	R:R:D114	R:R:N86	6.73	Yes	No	0	9	9
9	R:R:N86	R:R:P541	8.15	No	No	0	9	9
10	R:R:I87	R:R:L115	4.28	No	No	0	7	8
11	R:R:F555	R:R:L88	10.96	Yes	No	0	9	8
12	R:R:I90	R:R:L108	4.28	No	No	0	6	8
13	R:R:S92	R:R:T554	6.4	No	No	0	9	9
14	R:R:F555	R:R:S92	7.93	Yes	No	0	9	9
15	R:R:F93	R:R:K94	8.69	Yes	No	0	9	6
16	R:R:F93	R:R:K100	4.96	Yes	No	0	9	8
17	R:R:F93	R:R:Y105	5.16	Yes	No	0	9	8
18	R:R:L558	R:R:V95	4.47	No	No	0	8	8
19	R:R:N96	R:R:Q98	14.52	No	No	0	8	8
20	R:R:L99	R:R:N96	12.36	Yes	No	0	9	8
21	R:R:N96	R:R:T554	8.77	No	No	0	8	9
22	R:R:Q98	R:R:T550	9.92	No	No	0	8	8
23	R:R:L99	R:R:N104	5.49	Yes	Yes	5	9	9
24	R:R:L99	R:R:T550	5.9	Yes	No	0	9	8
25	R:R:F551	R:R:L99	14.61	Yes	Yes	5	9	9
26	R:R:N104	R:R:T101	7.31	Yes	No	0	9	8
27	R:R:R180	R:R:V102	9.15	Yes	No	0	9	8
28	R:R:N103	R:R:N104	4.09	No	Yes	0	9	9
29	R:R:N103	R:R:R177	8.44	No	No	0	9	8
30	R:R:F551	R:R:N104	10.87	Yes	Yes	5	9	9
31	R:R:F106	R:R:V161	5.24	Yes	No	2	8	8
32	R:R:F106	R:R:I162	3.77	Yes	No	0	8	9
33	R:R:D165	R:R:F106	10.75	No	Yes	2	9	8
34	R:R:F106	R:R:M188	4.98	Yes	No	2	8	8
35	R:R:F106	R:R:I189	3.77	Yes	No	0	8	9
36	R:R:N158	R:R:S109	5.96	No	No	0	9	9
37	R:R:I189	R:R:S109	9.29	No	No	0	9	9
38	R:R:D114	R:R:L110	4.07	Yes	No	1	9	9
39	R:R:L110	R:R:L159	5.54	No	No	1	9	9
40	R:R:L110	R:R:N540	9.61	No	Yes	1	9	9
41	R:R:D114	R:R:S155	5.89	Yes	No	0	9	9
42	R:R:D114	R:R:S537	10.31	Yes	No	0	9	9
43	R:R:D114	R:R:N540	8.08	Yes	Yes	1	9	9
44	R:R:I117	R:R:S121	7.74	Yes	No	1	9	9
45	R:R:I117	R:R:Y534	4.84	Yes	Yes	1	9	9
46	R:R:I117	R:R:S537	10.84	Yes	No	0	9	9
47	R:R:D148	R:R:S121	10.31	No	No	1	9	9
48	R:R:S121	R:R:Y534	5.09	No	Yes	1	9	9
49	R:R:M122	R:R:Y534	8.38	No	Yes	0	9	9
50	R:R:L124	R:R:W144	12.53	No	No	0	8	8
51	R:R:F125	R:R:I129	10.05	Yes	No	1	8	8
52	R:R:F125	R:R:N527	6.04	Yes	No	1	8	6
53	R:R:F125	R:R:Y530	11.35	Yes	Yes	1	8	7
54	R:R:F125	R:R:W531	4.01	Yes	Yes	1	8	8
55	R:R:F125	R:R:Y534	4.13	Yes	Yes	1	8	9
56	R:R:W134	R:R:Y128	5.79	No	No	0	9	8
57	R:R:E220	R:R:Y128	4.49	No	No	0	4	8
58	R:R:C221	R:R:Y128	4.03	No	No	0	9	8
59	R:R:I129	R:R:N527	11.33	No	No	1	8	6
60	R:R:M131	R:R:R133	12.41	No	No	0	7	5
61	R:R:L136	R:R:W134	14.81	No	No	0	8	9
62	R:R:C141	R:R:W134	16.98	No	No	0	9	9
63	R:R:N138	R:R:R214	6.03	No	Yes	0	5	7
64	R:R:C141	R:R:C221	7.28	No	No	0	9	9
65	R:R:D142	R:R:I204	4.2	No	Yes	0	8	8
66	R:R:D142	R:R:R214	7.15	No	Yes	0	8	7
67	R:R:I204	R:R:L145	5.71	Yes	Yes	1	8	8
68	R:R:I223	R:R:L145	4.28	Yes	Yes	1	8	8
69	R:R:D148	R:R:Y534	10.34	No	Yes	1	9	9
70	L:L:?1	R:R:D148	6.78	Yes	No	1	0	9
71	R:R:W200	R:R:Y149	20.26	Yes	Yes	1	9	9
72	R:R:I223	R:R:Y149	8.46	Yes	Yes	1	8	9
73	R:R:Y149	R:R:Y507	3.97	Yes	Yes	1	9	9
74	R:R:Y149	R:R:Y530	3.97	Yes	Yes	1	9	7
75	L:L:?1	R:R:Y149	6.69	Yes	Yes	1	0	9
76	L:L:?1	R:R:S152	7.5	Yes	No	0	0	9
77	R:R:M157	R:R:N153	4.21	No	Yes	0	8	9
78	R:R:N153	R:R:S196	8.94	Yes	No	0	9	9
79	R:R:N153	R:R:W200	6.78	Yes	Yes	0	9	9
80	R:R:A154	R:R:W193	7.78	No	No	0	9	9
81	R:R:F500	R:R:V156	7.87	Yes	Yes	1	9	9
82	R:R:V156	R:R:W504	4.9	Yes	Yes	1	9	9
83	L:L:?1	R:R:V156	4.25	Yes	Yes	1	0	9
84	R:R:A192	R:R:N158	4.69	No	No	0	9	9
85	R:R:L159	R:R:N540	4.12	No	Yes	1	9	9
86	R:R:L159	R:R:Y544	14.07	No	No	0	9	9
87	R:R:L160	R:R:S163	4.5	No	No	0	8	9
88	R:R:I246	R:R:L160	5.71	No	No	0	8	8
89	R:R:M188	R:R:V161	9.13	No	No	2	8	8
90	R:R:I162	R:R:R166	3.76	No	No	0	9	9
91	R:R:F164	R:R:I246	3.77	No	No	0	8	8
92	R:R:F164	R:R:L250	6.09	No	No	0	8	8
93	R:R:D165	R:R:Y176	6.9	No	Yes	2	9	9
94	R:R:D165	R:R:R180	11.91	No	Yes	2	9	9
95	R:R:R166	R:R:Y251	7.2	No	No	0	9	9
96	R:R:R166	R:R:Y544	4.12	No	No	0	9	9
97	R:R:F168	R:R:Y167	6.19	No	Yes	0	7	9
98	R:R:T171	R:R:Y167	11.24	No	Yes	0	8	9
99	R:R:L250	R:R:Y167	10.55	No	Yes	0	8	9
100	R:R:R253	R:R:Y167	4.12	No	Yes	0	8	9
101	R:R:F168	R:R:Y176	14.44	No	Yes	0	7	9
102	R:R:S169	R:R:Y176	3.82	No	Yes	0	9	9
103	R:R:R177	R:R:S169	10.54	No	No	0	8	9
104	R:R:E257	R:R:I170	4.1	No	No	0	8	8
105	R:R:R172	R:R:T171	6.47	No	No	0	8	8
106	R:R:E257	R:R:T171	9.88	No	No	0	8	8
107	R:R:R172	R:R:T175	3.88	No	No	0	8	7
108	R:R:R180	R:R:Y176	12.35	Yes	Yes	2	9	9
109	R:R:R177	R:R:R180	7.46	No	Yes	0	8	9
110	R:R:K183	R:R:T181	12.01	No	No	0	5	9
111	R:R:K183	R:R:R184	4.95	No	No	0	5	8
112	R:R:A201	R:R:F197	4.16	Yes	No	0	8	5
113	R:R:I223	R:R:W200	5.87	Yes	Yes	1	8	9
114	R:R:F225	R:R:W200	6.01	Yes	Yes	1	9	9
115	R:R:T235	R:R:W200	7.28	No	Yes	0	9	9
116	R:R:I204	R:R:I223	5.89	Yes	Yes	1	8	8
117	R:R:Q224	R:R:W207	4.38	Yes	No	0	8	6
118	R:R:F225	R:R:W207	9.02	Yes	No	0	9	6
119	R:R:Q208	R:R:R214	17.52	No	Yes	3	7	7
120	R:R:Q208	R:R:Q224	3.84	No	Yes	3	7	8
121	R:R:R214	R:R:V216	6.54	Yes	No	3	7	7
122	R:R:Q224	R:R:R214	4.67	Yes	Yes	3	8	7
123	R:R:Q224	R:R:T215	8.5	Yes	No	0	8	8
124	R:R:F222	R:R:V216	13.11	No	No	0	4	7
125	R:R:Q224	R:R:V216	4.3	Yes	No	3	8	7
126	R:R:E220	R:R:P217	7.86	No	No	0	4	4
127	R:R:F225	R:R:I223	12.56	Yes	Yes	1	9	8
128	R:R:E228	R:R:F225	8.16	Yes	Yes	1	8	9
129	R:R:F225	R:R:I231	6.28	Yes	No	1	9	8
130	R:R:E228	R:R:T230	11.29	Yes	No	0	8	5
131	R:R:E228	R:R:I231	9.56	Yes	No	1	8	8
132	R:R:E228	R:R:T232	7.06	Yes	No	0	8	8
133	R:R:F233	R:R:I237	6.28	No	No	0	8	7
134	R:R:F233	R:R:L512	8.53	No	No	0	8	7
135	R:R:I237	R:R:Y241	4.84	No	Yes	0	7	8
136	L:L:?1	R:R:A239	5.62	Yes	No	0	0	9
137	R:R:F240	R:R:Y241	6.19	Yes	Yes	1	9	8
138	R:R:F240	R:R:V244	3.93	Yes	No	1	9	8
139	R:R:F240	R:R:F500	4.29	Yes	Yes	1	9	9
140	R:R:F240	R:R:W504	5.01	Yes	Yes	1	9	9
141	R:R:F240	R:R:T505	3.89	Yes	No	0	9	8
142	R:R:F240	R:R:N508	16.92	Yes	Yes	1	9	9
143	L:L:?1	R:R:F240	5.21	Yes	Yes	1	0	9
144	R:R:N508	R:R:Y241	6.98	Yes	Yes	1	9	8
145	R:R:L512	R:R:Y241	5.86	No	Yes	0	7	8
146	R:R:F500	R:R:V244	3.93	Yes	No	1	9	8
147	R:R:L497	R:R:T248	5.9	No	No	0	9	7
148	R:R:L493	R:R:Y251	4.69	No	No	0	9	9
149	R:R:I496	R:R:Y251	8.46	Yes	No	0	9	9
150	R:R:K256	R:R:W252	10.44	No	No	0	5	7
151	R:R:E259	R:R:Y255	15.71	No	No	0	7	7
152	R:R:E259	R:R:E486	3.81	No	No	0	7	9
153	R:R:E486	R:R:K487	18.9	No	No	0	9	7
154	R:R:K488	R:R:Q491	4.07	No	No	0	9	8
155	R:R:Q491	R:R:T492	4.25	No	No	0	8	9
156	R:R:I496	R:R:Y544	9.67	Yes	No	0	9	9
157	R:R:F500	R:R:W504	5.01	Yes	Yes	1	9	9
158	R:R:I501	R:R:T505	4.56	No	No	0	8	8
159	R:R:T503	R:R:W504	4.85	No	Yes	1	9	9
160	R:R:I535	R:R:T503	4.56	No	No	0	7	9
161	R:R:N536	R:R:T503	4.39	No	No	1	9	9
162	R:R:C533	R:R:W504	10.45	No	Yes	1	9	9
163	R:R:N536	R:R:W504	9.04	No	Yes	1	9	9
164	L:L:?1	R:R:W504	18.69	Yes	Yes	1	0	9
165	R:R:N508	R:R:Y507	4.65	Yes	Yes	1	9	9
166	R:R:V511	R:R:Y507	3.79	No	Yes	0	8	9
167	L:L:?1	R:R:Y507	7.53	Yes	Yes	1	0	9
168	L:L:?1	R:R:N508	4.9	Yes	Yes	1	0	9
169	R:R:F516	R:R:V513	6.55	No	No	0	7	7
170	R:R:I521	R:R:N514	7.08	Yes	No	0	8	7
171	R:R:F516	R:R:T515	6.49	No	No	0	7	8
172	R:R:C517	R:R:C520	7.28	No	No	0	8	8
173	R:R:D518	R:R:S519	5.89	No	No	0	3	3
174	R:R:K523	R:R:W526	6.96	No	No	0	3	6
175	R:R:N527	R:R:W526	4.52	No	No	0	6	6
176	R:R:Y530	R:R:Y534	6.95	Yes	Yes	1	7	9
177	L:L:?1	R:R:Y530	14.22	Yes	Yes	1	0	7
178	R:R:W531	R:R:Y534	4.82	Yes	Yes	1	8	9
179	R:R:I535	R:R:W531	7.05	No	Yes	0	7	8
180	L:L:?1	R:R:C533	10.19	Yes	No	1	0	9
181	L:L:?1	R:R:Y534	5.02	Yes	Yes	1	0	9
182	R:R:N536	R:R:N540	12.26	No	Yes	1	9	9
183	R:R:F555	R:R:L546	7.31	Yes	No	0	9	8
184	R:R:N548	R:R:T550	8.77	No	No	0	9	8
185	R:R:F551	R:R:N548	7.25	Yes	No	0	9	9
186	R:R:K549	R:R:R552	14.85	No	No	0	7	9
187	R:R:K549	R:R:T553	6.01	No	No	0	7	7
188	R:R:K556	R:R:R552	4.95	No	No	0	7	9
189	R:R:F93	R:R:L108	3.65	Yes	No	0	9	8
190	R:R:G118	R:R:T82	3.64	No	No	0	8	9
191	R:R:G118	R:R:I83	3.53	No	No	0	8	8
192	R:R:P243	R:R:V156	3.53	No	Yes	0	9	9
193	R:R:P229	R:R:T515	3.5	No	No	0	6	8
194	R:R:L145	R:R:W144	3.42	Yes	No	0	8	8
195	R:R:A154	R:R:S196	3.42	No	No	0	9	9
196	R:R:A111	R:R:V89	3.39	No	No	0	9	9
197	R:R:I521	R:R:P522	3.39	Yes	No	0	8	7
198	R:R:C547	R:R:T492	3.38	No	No	0	9	9
199	R:R:M242	R:R:P243	3.35	No	No	0	7	9
200	R:R:L532	R:R:P506	3.28	No	No	0	9	9
201	R:R:C543	R:R:I496	3.27	No	Yes	0	9	9
202	R:R:A111	R:R:I90	3.25	No	No	0	9	6
203	R:R:A151	R:R:I116	3.25	No	No	0	8	8
204	R:R:C561	R:R:M557	3.24	No	No	0	6	6
205	R:R:A135	R:R:M131	3.22	No	No	0	7	7
206	R:R:C221	R:R:L145	3.17	No	Yes	0	9	8
207	R:R:T232	R:R:T515	3.14	No	No	0	8	8
208	R:R:I120	R:R:V119	3.07	No	No	0	6	6
209	R:R:M247	R:R:S163	3.07	No	No	0	9	9
210	R:R:I130	R:R:M131	2.92	Yes	No	0	7	7
211	R:R:I521	R:R:M510	2.92	Yes	No	0	8	7
212	R:R:K100	R:R:K97	2.87	No	No	0	8	8
213	R:R:I195	R:R:L191	2.85	No	No	0	6	5
214	R:R:I223	R:R:L226	2.85	Yes	No	0	8	7
215	R:R:E259	R:R:T258	2.82	No	No	0	7	9
216	R:R:C517	R:R:F516	2.79	No	No	0	8	7
217	R:R:L74	R:R:L78	2.77	No	No	0	5	7
218	R:R:A203	R:R:F225	2.77	No	Yes	0	7	9
219	R:R:A545	R:R:F551	2.77	No	Yes	0	9	9
220	R:R:D142	R:R:L205	2.71	No	No	0	8	7
221	R:R:A236	R:R:Y241	2.67	No	Yes	0	9	8
222	R:R:A489	R:R:Y255	2.67	No	No	0	9	7
223	R:R:L139	R:R:Q208	2.66	No	No	0	5	7
224	R:R:F555	R:R:V89	2.62	Yes	No	0	9	9
225	R:R:F210	R:R:V211	2.62	No	No	0	6	6
226	R:R:A113	R:R:W193	2.59	No	No	0	9	9
227	R:R:R261	R:R:T262	2.59	No	No	0	8	7
228	R:R:I249	R:R:R253	2.51	No	No	0	7	8
229	R:R:T182	R:R:Y105	2.5	No	No	0	8	8
230	R:R:F525	R:R:M510	2.49	No	No	0	6	7
231	R:R:I254	R:R:Y167	2.42	No	Yes	0	9	9
232	R:R:I509	R:R:Y241	2.42	No	Yes	0	8	8
233	R:R:I120	R:R:W144	2.35	No	No	0	6	8
234	R:R:I521	R:R:W526	2.35	Yes	No	0	8	6
235	R:R:L493	R:R:Y255	2.34	No	No	0	9	7
236	R:R:Q67	R:R:W66	2.19	No	No	0	7	4
237	R:R:G85	R:R:P541	2.03	No	No	0	9	9
238	R:R:G529	R:R:P506	2.03	No	No	0	8	9
239	R:R:A79	R:R:G76	1.95	No	No	0	8	7
240	R:R:A140	R:R:G137	1.95	No	No	0	7	9
241	R:R:P217	R:R:P218	1.95	No	No	0	4	3
242	R:R:A201	R:R:P202	1.87	Yes	No	0	8	9
243	R:R:G212	R:R:V211	1.84	No	No	0	6	6
244	R:R:A146	R:R:A201	1.79	No	Yes	0	7	8
245	R:R:G85	R:R:I84	1.76	No	No	0	9	6
246	R:R:P506	R:R:T505	1.75	No	No	0	9	8
247	R:R:G529	R:R:M510	1.75	No	No	0	8	7
248	R:R:G137	R:R:L136	1.71	No	No	0	9	8
249	R:R:G529	R:R:L528	1.71	No	No	0	8	6
250	R:R:A72	R:R:V69	1.7	No	No	0	8	6
251	R:R:A185	R:R:V102	1.7	No	No	0	8	8
252	R:R:A201	R:R:V150	1.7	Yes	No	0	8	9
253	R:R:A499	R:R:V539	1.7	No	No	0	8	7
254	R:R:A72	R:R:I130	1.62	No	Yes	0	8	7
255	R:R:A151	R:R:I117	1.62	No	Yes	0	8	9
256	R:R:A146	R:R:I204	1.62	No	Yes	0	7	8
257	R:R:S196	R:R:V150	1.62	No	No	0	9	9
258	R:R:V194	R:R:V198	1.6	No	No	0	5	6
259	R:R:T538	R:R:V81	1.59	No	No	0	8	5
260	R:R:T554	R:R:V95	1.59	No	No	0	9	8
261	R:R:T538	R:R:V539	1.59	No	No	0	8	7
262	R:R:A545	R:R:L107	1.58	No	No	0	9	9
263	R:R:A238	R:R:L199	1.58	No	No	0	8	8
264	R:R:T126	R:R:T127	1.57	No	No	4	9	7
265	R:R:A79	R:R:N123	1.56	No	No	0	8	9
266	R:R:I87	R:R:V91	1.54	No	No	0	7	6
267	R:R:I130	R:R:T126	1.52	Yes	No	4	7	9
268	R:R:I130	R:R:T127	1.52	Yes	No	4	7	7
269	R:R:I246	R:R:T245	1.52	No	No	0	8	7
270	R:R:I496	R:R:T492	1.52	Yes	No	0	9	9
271	R:R:G219	R:R:R133	1.5	No	No	0	3	5
272	R:R:L558	R:R:V91	1.49	No	No	0	8	6
273	R:R:I116	R:R:I147	1.47	No	No	0	8	6
274	R:R:I120	R:R:I147	1.47	No	No	0	6	6
275	R:R:L174	R:R:T175	1.47	No	No	0	8	7
276	R:R:P173	R:R:R172	1.44	No	No	0	9	8
277	R:R:I195	R:R:L199	1.43	No	No	0	6	8
278	R:R:L497	R:R:M247	1.41	No	No	0	9	9
279	R:R:L143	R:R:L205	1.38	No	No	0	6	7
280	R:R:L199	R:R:N153	1.37	No	Yes	0	8	9
281	R:R:E264	R:R:K260	1.35	No	No	0	7	7
282	R:R:F197	R:R:V198	1.31	No	No	0	5	6
283	R:R:K179	R:R:R184	1.24	No	No	0	7	8
284	R:R:V65	R:R:W66	1.23	No	No	0	4	4
285	R:R:F206	R:R:L205	1.22	No	No	0	7	7
286	R:R:R180	R:R:R184	1.07	Yes	No	0	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F93	5.615	4	0	9
2	R:R:L99	9.59	4	5	9
3	R:R:N104	6.94	4	5	9
4	R:R:F106	5.702	5	2	8
5	R:R:D114	7.016	5	1	9
6	R:R:I117	6.26	4	1	9
7	R:R:F125	7.116	5	1	8
8	R:R:I130	1.895	4	4	7
9	R:R:L145	4.145	4	1	8
10	R:R:Y149	8.67	5	1	9
11	R:R:N153	5.325	4	0	9
12	R:R:V156	5.1375	4	1	9
13	R:R:Y167	6.904	5	0	9
14	R:R:Y176	9.3775	4	2	9
15	R:R:R180	8.388	5	2	9
16	R:R:W200	9.24	5	1	9
17	R:R:A201	2.38	4	0	8
18	R:R:I204	4.355	4	1	8
19	R:R:R214	8.382	5	3	7
20	R:R:I223	6.65167	6	1	8
21	R:R:Q224	5.138	5	3	8
22	R:R:F225	7.46667	6	1	9
23	R:R:E228	9.0175	4	1	8
24	R:R:F240	6.49143	7	1	9
25	R:R:Y241	4.82667	6	1	8
26	R:R:I496	5.73	4	0	9
27	R:R:F500	5.275	4	1	9
28	R:R:W504	8.27857	7	1	9
29	R:R:Y507	4.985	4	1	9
30	R:R:N508	8.3625	4	1	9
31	R:R:I521	3.935	4	0	8
32	R:R:Y530	9.1225	4	1	7
33	R:R:W531	7.21	5	1	8
34	R:R:Y534	6.19625	8	1	9
35	R:R:N540	8.5175	4	1	9
36	R:R:F551	8.875	4	5	9
37	R:R:F555	7.205	4	0	9
38	L:L:?1	8.05	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T126	R:R:T75	17.0643	7.85	No	No	0	9	8
2	R:R:T75	R:R:W531	18.699	13.34	No	Yes	0	8	8
3	R:R:M122	R:R:Y534	25.8184	8.38	No	Yes	0	9	9
4	R:R:W531	R:R:Y534	14.0723	4.82	Yes	Yes	1	8	9
5	R:R:M122	R:R:T82	16.5479	6.02	No	No	0	9	9
6	R:R:D114	R:R:S537	29.122	10.31	Yes	No	0	9	9
7	R:R:I117	R:R:S537	29.3354	10.84	Yes	No	0	9	9
8	R:R:I117	R:R:Y534	26.2324	4.84	Yes	Yes	1	9	9
9	R:R:N96	R:R:T554	29.28	8.77	No	No	0	8	9
10	R:R:L99	R:R:N96	31.8366	12.36	Yes	No	0	9	8
11	R:R:L99	R:R:N104	35.4689	5.49	Yes	Yes	5	9	9
12	R:R:N103	R:R:N104	43.5913	4.09	No	Yes	0	9	9
13	R:R:N103	R:R:R177	44.8461	8.44	No	No	0	9	8
14	R:R:R177	R:R:R180	42.9425	7.46	No	Yes	0	8	9
15	R:R:D165	R:R:R180	47.0058	11.91	No	Yes	2	9	9
16	R:R:D165	R:R:F106	74.9285	10.75	No	Yes	2	9	8
17	R:R:F106	R:R:I162	81.015	3.77	Yes	No	0	8	9
18	R:R:I162	R:R:R166	81.8259	3.76	No	No	0	9	9
19	R:R:R166	R:R:Y544	86.5551	4.12	No	No	0	9	9
20	R:R:L159	R:R:Y544	100	14.07	No	No	0	9	9
21	R:R:L159	R:R:N540	86.2734	4.12	No	Yes	1	9	9
22	R:R:N536	R:R:N540	76.3199	12.26	No	Yes	1	9	9
23	R:R:I535	R:R:T503	10.0132	4.56	No	No	0	7	9
24	R:R:I535	R:R:W531	10.4059	7.05	No	Yes	0	7	8
25	R:R:F555	R:R:S92	19.3521	7.93	Yes	No	0	9	9
26	R:R:S92	R:R:T554	20.8033	6.4	No	No	0	9	9
27	R:R:A111	R:R:I90	12.015	3.25	No	No	0	9	6
28	R:R:A111	R:R:V89	13.5004	3.39	No	No	0	9	9
29	R:R:F555	R:R:V89	14.9686	2.62	Yes	No	0	9	9
30	R:R:I90	R:R:L108	10.5211	4.28	No	No	0	6	8
31	R:R:D114	R:R:L110	14.1918	4.07	Yes	No	1	9	9
32	R:R:I223	R:R:L145	20.8545	4.28	Yes	Yes	1	8	8
33	R:R:I223	R:R:Y149	58.8331	8.46	Yes	Yes	1	8	9
34	R:R:Y149	R:R:Y530	22.5789	3.97	Yes	Yes	1	9	7
35	R:R:F125	R:R:Y530	13.1632	11.35	Yes	Yes	1	8	7
36	R:R:Y530	R:R:Y534	13.4918	6.95	Yes	Yes	1	7	9
37	L:L:?1	R:R:Y149	67.6725	6.69	Yes	Yes	1	0	9
38	L:L:?1	R:R:Y534	27.5044	5.02	Yes	Yes	1	0	9
39	R:R:F125	R:R:N527	18.2594	6.04	Yes	No	1	8	6
40	R:R:C221	R:R:L145	18.3192	3.17	No	Yes	0	9	8
41	R:R:C221	R:R:Y128	10.598	4.03	No	No	0	9	8
42	R:R:I130	R:R:T126	13.2528	1.52	Yes	No	4	7	9
43	R:R:D142	R:R:I204	12.9113	4.2	No	Yes	0	8	8
44	R:R:I204	R:R:I223	19.2496	5.89	Yes	Yes	1	8	8
45	R:R:W200	R:R:Y149	34.4061	20.26	Yes	Yes	1	9	9
46	R:R:N153	R:R:W200	14.418	6.78	Yes	Yes	0	9	9
47	L:L:?1	R:R:F240	10.1925	5.21	Yes	Yes	1	0	9
48	L:L:?1	R:R:W504	56.5069	18.69	Yes	Yes	1	0	9
49	R:R:F164	R:R:I246	10.9608	3.77	No	No	0	8	8
50	R:R:F164	R:R:L250	12.4931	6.09	No	No	0	8	8
51	R:R:L250	R:R:Y167	14.0168	10.55	No	Yes	0	8	9
52	R:R:F168	R:R:Y167	29.8775	6.19	No	Yes	0	7	9
53	R:R:F168	R:R:Y176	31.2988	14.44	No	Yes	0	7	9
54	R:R:D165	R:R:Y176	27.0093	6.9	No	Yes	2	9	9
55	R:R:R166	R:R:Y251	12.4504	7.2	No	No	0	9	9
56	R:R:I496	R:R:Y544	16.4156	9.67	Yes	No	0	9	9
57	R:R:I496	R:R:Y251	10.2096	8.46	Yes	No	0	9	9
58	R:R:T171	R:R:Y167	10.7815	11.24	No	Yes	0	8	9
59	R:R:F225	R:R:W200	21.4051	6.01	Yes	Yes	1	9	9
60	R:R:F225	R:R:I223	22.3484	12.56	Yes	Yes	1	9	8
61	R:R:Q224	R:R:W207	13.8888	4.38	Yes	No	0	8	6
62	R:R:F225	R:R:W207	16.2406	9.02	Yes	No	0	9	6
63	R:R:E228	R:R:F225	21.738	8.16	Yes	Yes	1	8	9
64	R:R:E228	R:R:T232	16.996	7.06	Yes	No	0	8	8
65	R:R:F240	R:R:T505	10.1584	3.89	Yes	No	0	9	8
66	R:R:L493	R:R:Y251	16.9448	4.69	No	No	0	9	9
67	R:R:L493	R:R:Y255	14.5034	2.34	No	No	0	9	7
68	R:R:T232	R:R:T515	14.593	3.14	No	No	0	8	8
69	R:R:N527	R:R:W526	15.5619	4.52	No	No	0	6	6
70	R:R:L110	R:R:L159	14.3839	5.54	No	No	1	9	9
71	R:R:D114	R:R:N540	17.2308	8.08	Yes	Yes	1	9	9
72	R:R:N536	R:R:W504	66.9341	9.04	No	Yes	1	9	9
73	R:R:F125	R:R:Y534	11.7333	4.13	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I117	R:R:S121	7.74	1	Yes	No	9	9	2	2
R:R:I117	R:R:Y534	4.84	1	Yes	Yes	9	9	2	1
R:R:D148	R:R:S121	10.31	1	No	No	9	9	1	2
R:R:S121	R:R:Y534	5.09	1	No	Yes	9	9	2	1
R:R:M122	R:R:Y534	8.38	0	No	Yes	9	9	2	1
R:R:F125	R:R:Y530	11.35	1	Yes	Yes	8	7	2	1
R:R:F125	R:R:W531	4.01	1	Yes	Yes	8	8	2	2
R:R:F125	R:R:Y534	4.13	1	Yes	Yes	8	9	2	1
R:R:D148	R:R:Y534	10.34	1	No	Yes	9	9	1	1
L:L:?1	R:R:D148	6.78	1	Yes	No	0	9	0	1
R:R:W200	R:R:Y149	20.26	1	Yes	Yes	9	9	2	1
R:R:I223	R:R:Y149	8.46	1	Yes	Yes	8	9	2	1
R:R:Y149	R:R:Y507	3.97	1	Yes	Yes	9	9	1	1
R:R:Y149	R:R:Y530	3.97	1	Yes	Yes	9	7	1	1
L:L:?1	R:R:Y149	6.69	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S152	7.5	1	Yes	No	0	9	0	1
R:R:F500	R:R:V156	7.87	1	Yes	Yes	9	9	2	1
R:R:V156	R:R:W504	4.9	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:V156	4.25	1	Yes	Yes	0	9	0	1
R:R:I223	R:R:W200	5.87	1	Yes	Yes	8	9	2	2
L:L:?1	R:R:A239	5.62	1	Yes	No	0	9	0	1
R:R:F240	R:R:Y241	6.19	1	Yes	Yes	9	8	1	2
R:R:F240	R:R:V244	3.93	1	Yes	No	9	8	1	2
R:R:F240	R:R:F500	4.29	1	Yes	Yes	9	9	1	2
R:R:F240	R:R:W504	5.01	1	Yes	Yes	9	9	1	1
R:R:F240	R:R:T505	3.89	1	Yes	No	9	8	1	2
R:R:F240	R:R:N508	16.92	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:F240	5.21	1	Yes	Yes	0	9	0	1
R:R:N508	R:R:Y241	6.98	1	Yes	Yes	9	8	1	2
R:R:F500	R:R:V244	3.93	1	Yes	No	9	8	2	2
R:R:F500	R:R:W504	5.01	1	Yes	Yes	9	9	2	1
R:R:T503	R:R:W504	4.85	1	No	Yes	9	9	2	1
R:R:N536	R:R:T503	4.39	1	No	No	9	9	2	2
R:R:C533	R:R:W504	10.45	1	No	Yes	9	9	1	1
R:R:N536	R:R:W504	9.04	1	No	Yes	9	9	2	1
L:L:?1	R:R:W504	18.69	1	Yes	Yes	0	9	0	1
R:R:N508	R:R:Y507	4.65	1	Yes	Yes	9	9	1	1
R:R:V511	R:R:Y507	3.79	0	No	Yes	8	9	2	1
L:L:?1	R:R:Y507	7.53	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N508	4.9	1	Yes	Yes	0	9	0	1
R:R:Y530	R:R:Y534	6.95	1	Yes	Yes	7	9	1	1
L:L:?1	R:R:Y530	14.22	1	Yes	Yes	0	7	0	1
R:R:W531	R:R:Y534	4.82	1	Yes	Yes	8	9	2	1
L:L:?1	R:R:C533	10.19	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y534	5.02	1	Yes	Yes	0	9	0	1
R:R:P243	R:R:V156	3.53	0	No	Yes	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E9Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.76
Number of Linked Nodes	253
Number of Links	286
Number of Hubs	38
Number of Links mediated by Hubs	145
Number of Communities	5
Number of Nodes involved in Communities	49
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	48793
Length Of Smallest Path	3
Average Path Length	13.9942
Length of Longest Path	35
Minimum Path Strength	1.155
Average Path Strength	7.12548
Maximum Path Strength	16.455
Minimum Path Correlation	0.7
Average Path Correlation	0.919898
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	47.1021
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.921
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IXO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IXO
Name	4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
Synonyms	Iperoxo
Identifier
Formula	C10 H17 N2 O2
Molecular Weight	197.254
SMILES
PubChem	10104167
Formal Charge	1
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20309
Sequence	>8E9Z_nogp_Chain_R V W Q V V F I A F L T G I L A L V T I I G N I L V I V S F K V N K Q L K T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M N R W A L G N L A C D L W L A I D Y V A S N A S V M N L L V I S F D R Y F S I T R P L T Y R A K R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G K R T V P P G E C F I Q F L S E P T I T F G T A I A A F Y M P V T I M T I L Y W R I Y K E T E K R T K E L E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C D S C I P K T F W N L G Y W L C Y I N S T V N P V C Y A L C N K T F R T T F K M L L L C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4U14	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	3.57	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4U15	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	2.8	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4U16	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	N-Methyl-Scopolamine	-	-	3.7	2014-11-26	doi.org/10.1016/j.str.2014.08.022
	4DAJ	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	Tiotropium	-	-	3.4	2012-02-22	doi.org/10.1038/nature10867
	8E9W	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	2-Deoxycytidine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9W (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	2-Deoxycytidine	-		2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Y	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Clozapine-N-oxide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.79	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Y (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Clozapine-N-oxide	-		2.79	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Z	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9Z (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-		2.69	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8EA0	A	Amine	Acetylcholine (muscarinic)	M₃	Homo sapiens	Iperoxo	-	-	2.56	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	5ZHP	A	Amine	Acetylcholine (muscarinic)	M₃	Rattus norvegicus	PubChem 134828589	-	-	3.1	2018-11-28	doi.org/10.1073/pnas.1813988115
	7M3J	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3E	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium Sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	doi.org/10.1038/s41586-021-03691-0
	9CM3	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6
	9CM3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA2	Homo sapiens	TUG-1375	Compound 187		3.06	2025-06-25	doi.org/10.1038/s41586-025-09186-6

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