psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N19	L:L:W21	14.69	No	Yes	2	0	0
2	L:L:N19	R:R:T296	13.16	No	No	2	0	3
3	L:L:H20	R:R:W106	3.17	No	Yes	0	0	8
4	L:L:H20	R:R:S195	6.97	No	No	0	0	4
5	L:L:W21	R:R:Y101	6.75	Yes	Yes	2	0	4
6	L:L:W21	R:R:T296	8.49	Yes	No	2	0	3
7	L:L:W21	R:R:F301	21.05	Yes	Yes	2	0	4
8	L:L:V23	R:R:F193	7.87	No	Yes	0	0	1
9	L:L:G24	R:R:R287	4.5	No	No	0	0	4
10	L:L:H25	R:R:P117	10.68	No	No	0	0	5
11	L:L:H25	R:R:P198	19.83	No	No	0	0	4
12	L:L:L26	L:L:M27	5.65	No	Yes	0	0	0
13	L:L:L26	R:R:Y284	16.41	No	Yes	0	0	5
14	L:L:M27	R:R:C93	3.24	Yes	No	0	0	7
15	L:L:M27	R:R:V124	6.09	Yes	No	0	0	7
16	L:L:M27	R:R:N280	8.41	Yes	No	0	0	5
17	R:R:P44	R:R:V42	8.84	No	No	0	6	5
18	R:R:I43	R:R:P44	3.39	No	No	0	6	6
19	R:R:I51	R:R:Y47	12.09	No	Yes	2	7	7
20	R:R:D97	R:R:Y47	3.45	No	Yes	2	6	7
21	R:R:L309	R:R:Y47	5.86	No	Yes	0	5	7
22	R:R:F312	R:R:Y47	8.25	Yes	Yes	2	7	7
23	R:R:I50	R:R:T313	3.04	No	No	0	7	5
24	R:R:C316	R:R:I50	6.55	No	No	0	7	7
25	R:R:A94	R:R:I51	3.25	No	No	0	7	7
26	R:R:F312	R:R:I51	3.77	Yes	No	2	7	7
27	R:R:G54	R:R:I53	3.53	No	No	0	8	6
28	R:R:C316	R:R:G54	3.92	No	No	0	7	8
29	R:R:I59	R:R:L55	4.28	No	No	0	4	6
30	R:R:G57	R:R:P319	4.06	No	No	0	8	9
31	R:R:F320	R:R:G57	3.01	No	No	0	5	8
32	R:R:D86	R:R:N58	6.73	Yes	No	0	9	9
33	R:R:L87	R:R:N58	5.49	No	No	0	8	9
34	R:R:N58	R:R:P319	6.52	No	No	0	9	9
35	R:R:I64	R:R:T60	3.04	Yes	No	0	7	7
36	R:R:F333	R:R:T60	9.08	Yes	No	0	7	7
37	R:R:L337	R:R:T60	8.84	No	No	0	7	7
38	R:R:I79	R:R:L61	4.28	No	No	0	8	9
39	R:R:A83	R:R:L61	6.3	No	No	0	9	9
40	R:R:A83	R:R:I62	3.25	No	No	0	9	7
41	R:R:K63	R:R:Q336	10.85	No	No	0	4	5
42	R:R:I64	R:R:Q336	8.23	Yes	No	0	7	5
43	R:R:F65	R:R:R72	5.34	No	No	0	7	7
44	R:R:F65	R:R:S80	18.5	No	No	0	7	5
45	R:R:Q336	R:R:T67	5.67	No	No	0	5	5
46	R:R:S70	R:R:V68	4.85	No	No	0	6	6
47	R:R:K69	R:R:R72	11.14	No	No	0	5	7
48	R:R:M71	R:R:S70	3.07	No	No	0	7	6
49	R:R:M71	R:R:N76	8.41	No	No	0	7	8
50	R:R:N73	R:R:P75	11.4	No	No	0	8	8
51	R:R:N73	R:R:N76	9.54	No	No	0	8	8
52	R:R:P75	R:R:V74	3.53	No	Yes	0	8	7
53	R:R:I157	R:R:V74	3.07	No	Yes	0	7	7
54	R:R:I157	R:R:L77	5.71	No	No	0	7	6
55	R:R:D137	R:R:F78	13.14	No	No	0	8	7
56	R:R:F78	R:R:I157	11.3	No	No	0	7	7
57	R:R:F78	R:R:K160	6.2	No	No	0	7	6
58	R:R:I79	R:R:L322	7.14	No	No	0	8	9
59	R:R:S81	R:R:T130	6.4	No	No	0	9	8
60	R:R:D86	R:R:L82	8.14	Yes	Yes	3	9	9
61	R:R:L82	R:R:T130	5.9	Yes	No	0	9	8
62	R:R:L82	R:R:Q131	3.99	Yes	No	3	9	9
63	R:R:L82	R:R:N318	12.36	Yes	No	3	9	9
64	R:R:D86	R:R:S127	4.42	Yes	No	0	9	9
65	R:R:D86	R:R:S315	4.42	Yes	No	0	9	8
66	R:R:D86	R:R:N318	10.77	Yes	No	3	9	9
67	R:R:L88	R:R:S123	9.01	No	No	0	7	8
68	R:R:C93	R:R:L89	4.76	No	No	0	7	7
69	R:R:L89	R:R:S123	6.01	No	No	0	7	8
70	R:R:L89	R:R:V124	5.96	No	No	0	7	7
71	R:R:L90	R:R:S315	4.5	No	No	0	6	8
72	R:R:C316	R:R:L90	3.17	No	No	0	7	6
73	R:R:Q120	R:R:T92	9.92	No	No	0	6	5
74	R:R:C93	R:R:F312	4.19	No	Yes	0	7	7
75	R:R:Q120	R:R:V96	4.3	No	No	0	6	6
76	R:R:D97	R:R:Y101	9.2	No	Yes	2	6	4
77	R:R:D97	R:R:R308	11.91	No	No	2	6	5
78	R:R:R100	R:R:W106	14.99	No	Yes	0	5	8
79	R:R:R100	R:R:S195	5.27	No	No	0	5	4
80	R:R:F301	R:R:Y101	6.19	Yes	Yes	2	4	4
81	R:R:I305	R:R:Y101	6.04	No	Yes	2	4	4
82	R:R:R308	R:R:Y101	9.26	No	Yes	2	5	4
83	R:R:F108	R:R:W106	12.03	No	Yes	0	7	8
84	R:R:C196	R:R:W106	6.53	No	Yes	0	9	8
85	R:R:F108	R:R:I116	8.79	No	No	0	7	5
86	R:R:K114	R:R:R110	9.9	No	No	0	7	4
87	R:R:D180	R:R:R110	3.57	No	No	0	4	4
88	R:R:L181	R:R:R110	6.07	No	No	0	4	4
89	R:R:C113	R:R:L181	4.76	No	No	0	9	4
90	R:R:C113	R:R:C196	7.28	No	No	0	9	9
91	R:R:I116	R:R:P117	5.08	No	No	0	5	5
92	R:R:P117	R:R:Q120	3.16	No	No	0	5	6
93	R:R:F118	R:R:T122	5.19	No	Yes	0	6	5
94	R:R:F118	R:R:I173	3.77	No	No	0	6	4
95	R:R:A176	R:R:F118	4.16	No	No	0	5	6
96	R:R:I119	R:R:T122	4.56	No	Yes	0	5	5
97	R:R:A172	R:R:L121	4.73	No	No	0	7	4
98	R:R:E175	R:R:L121	3.98	No	No	0	5	4
99	R:R:F218	R:R:L121	8.53	Yes	No	0	6	4
100	R:R:S168	R:R:T122	4.8	No	Yes	0	8	5
101	R:R:M169	R:R:T122	3.01	No	Yes	0	4	5
102	R:R:A172	R:R:T122	3.36	No	Yes	0	7	5
103	R:R:F129	R:R:G125	3.01	Yes	No	0	5	6
104	R:R:F218	R:R:G125	3.01	Yes	No	0	6	6
105	R:R:T130	R:R:V126	3.17	No	No	0	8	7
106	R:R:V126	R:R:W165	17.16	No	No	0	7	9
107	R:R:S168	R:R:V126	4.85	No	No	0	8	7
108	R:R:P222	R:R:V128	3.53	No	No	0	9	8
109	R:R:V128	R:R:W277	4.9	No	Yes	0	8	8
110	R:R:F129	R:R:I164	6.28	Yes	No	0	5	7
111	R:R:F129	R:R:S168	5.28	Yes	No	0	5	8
112	R:R:F273	R:R:Q131	11.71	No	No	0	9	9
113	R:R:N318	R:R:Q131	9.24	No	No	3	9	9
114	R:R:I226	R:R:T132	7.6	No	No	0	8	7
115	R:R:A133	R:R:K160	3.21	No	No	0	7	6
116	R:R:L134	R:R:R138	8.5	No	No	0	9	9
117	R:R:I226	R:R:S135	3.1	No	No	4	8	9
118	R:R:S135	R:R:Y229	6.36	No	No	0	9	7
119	R:R:S135	R:R:Y230	10.17	No	Yes	4	9	8
120	R:R:R138	R:R:Y230	11.32	No	Yes	0	9	8
121	R:R:V143	R:R:Y139	16.4	No	No	0	7	8
122	R:R:Y139	R:R:Y229	9.93	No	No	0	8	7
123	R:R:F232	R:R:Y139	4.13	No	No	0	3	8
124	R:R:I148	R:R:K140	10.18	No	No	0	6	4
125	R:R:I142	R:R:I233	4.42	No	No	5	8	8
126	R:R:N236	R:R:V143	7.39	No	No	0	5	7
127	R:R:M146	R:R:P145	3.35	No	No	0	5	8
128	R:R:M146	R:R:Q149	5.44	No	No	0	5	5
129	R:R:H152	R:R:M155	7.88	No	No	0	7	3
130	R:R:F163	R:R:I167	11.3	No	No	0	3	4
131	R:R:I173	R:R:P174	3.39	No	No	0	4	7
132	R:R:E175	R:R:P198	4.72	No	No	0	5	4
133	R:R:E175	R:R:H210	12.31	No	No	0	5	6
134	R:R:F178	R:R:V177	5.24	No	No	0	5	4
135	R:R:F178	R:R:H206	9.05	No	Yes	0	5	1
136	R:R:D180	R:R:H182	11.35	No	Yes	0	4	1
137	R:R:D180	R:R:P200	4.83	No	No	0	4	5
138	R:R:I194	R:R:L181	8.56	No	No	0	4	4
139	R:R:F184	R:R:H182	5.66	Yes	Yes	1	2	1
140	R:R:A197	R:R:H182	5.85	No	Yes	0	1	1
141	R:R:H182	R:R:H201	10.75	Yes	No	1	1	3
142	R:R:H182	R:R:Y291	4.36	Yes	Yes	1	1	1
143	R:R:F184	R:R:F193	11.79	Yes	Yes	1	2	1
144	R:R:F184	R:R:H201	7.92	Yes	No	1	2	3
145	R:R:F184	R:R:Y291	8.25	Yes	Yes	1	2	1
146	R:R:E186	R:R:Q191	3.82	No	No	0	3	2
147	R:R:E186	R:R:F193	3.5	No	Yes	1	3	1
148	R:R:E186	R:R:V294	5.7	No	No	1	3	5
149	R:R:F193	R:R:V294	7.87	Yes	No	1	1	5
150	R:R:P198	R:R:Y199	5.56	No	Yes	0	4	5
151	R:R:P207	R:R:Y199	9.74	No	Yes	0	3	5
152	R:R:H210	R:R:Y199	11.98	No	Yes	0	6	5
153	R:R:Y199	R:R:Y284	8.94	Yes	Yes	1	5	5
154	R:R:S288	R:R:Y199	3.82	No	Yes	1	4	5
155	R:R:Y199	R:R:Y291	8.94	Yes	Yes	1	5	1
156	R:R:H206	R:R:P200	6.1	Yes	No	0	1	5
157	R:R:H201	R:R:Y291	6.53	No	Yes	1	3	1
158	R:R:H206	R:R:N203	3.83	Yes	No	0	1	2
159	R:R:H206	R:R:P207	4.58	Yes	No	0	1	3
160	R:R:H206	R:R:H210	3.58	Yes	No	0	1	6
161	R:R:K208	R:R:Y289	9.55	No	No	0	3	5
162	R:R:S211	R:R:Y284	6.36	No	Yes	1	5	5
163	R:R:L285	R:R:S211	4.5	No	No	0	5	5
164	R:R:S211	R:R:S288	6.52	No	No	1	5	4
165	R:R:F218	R:R:S214	6.61	Yes	No	0	6	6
166	R:R:F215	R:R:Y219	11.35	Yes	No	6	6	8
167	R:R:F215	R:R:V220	3.93	Yes	No	0	6	5
168	R:R:F215	R:R:H281	7.92	Yes	No	6	6	7
169	R:R:F215	R:R:L285	15.83	Yes	No	0	6	5
170	R:R:L216	R:R:V220	5.96	No	No	0	4	5
171	R:R:F218	R:R:V217	5.24	Yes	No	0	6	5
172	R:R:L278	R:R:Y219	9.38	No	No	0	6	8
173	R:R:H281	R:R:Y219	19.6	No	No	6	7	8
174	R:R:I221	R:R:P222	3.39	No	No	0	5	9
175	R:R:F273	R:R:L223	6.09	No	No	0	9	6
176	R:R:I225	R:R:Y229	6.04	No	No	0	7	7
177	R:R:I226	R:R:Y230	4.84	No	Yes	4	8	8
178	R:R:F232	R:R:V228	3.93	No	No	0	3	4
179	R:R:V266	R:R:Y230	8.83	No	Yes	0	8	8
180	R:R:V270	R:R:Y230	5.05	No	Yes	0	7	8
181	R:R:K235	R:R:N236	4.2	No	No	0	3	5
182	R:R:L237	R:R:R259	4.86	Yes	No	0	8	7
183	R:R:I238	R:R:Y242	3.63	No	No	0	4	3
184	R:R:L244	R:R:P245	4.93	No	No	0	5	3
185	R:R:I256	R:R:L244	4.28	Yes	No	0	4	5
186	R:R:V246	R:R:V252	3.21	No	No	7	3	3
187	R:R:I256	R:R:V246	4.61	Yes	No	7	4	3
188	R:R:N249	R:R:V252	4.43	No	No	0	5	3
189	R:R:H251	R:R:I250	6.63	No	No	0	3	2
190	R:R:I256	R:R:V252	3.07	Yes	No	7	4	3
191	R:R:E257	R:R:K253	4.05	No	No	0	4	4
192	R:R:Q255	R:R:R259	5.84	No	No	0	3	7
193	R:R:L262	R:R:L325	5.54	No	No	0	8	7
194	R:R:F269	R:R:T265	5.19	No	No	0	7	8
195	R:R:L325	R:R:T265	5.9	No	No	0	7	8
196	R:R:C276	R:R:L272	3.17	Yes	No	0	8	7
197	R:R:F273	R:R:W277	18.04	No	Yes	0	9	8
198	R:R:C276	R:R:L310	6.35	Yes	Yes	0	8	8
199	R:R:C276	R:R:T313	3.38	Yes	No	0	8	5
200	R:R:C276	R:R:N314	6.3	Yes	No	0	8	9
201	R:R:H281	R:R:W277	7.41	No	Yes	0	7	8
202	R:R:N314	R:R:W277	15.82	No	Yes	0	9	8
203	R:R:L278	R:R:P279	3.28	No	No	0	6	9
204	R:R:L310	R:R:P279	3.28	Yes	No	0	8	9
205	R:R:A311	R:R:N280	4.69	No	No	0	8	5
206	R:R:I283	R:R:T303	6.08	No	No	0	5	4
207	R:R:A307	R:R:I283	3.25	No	No	0	6	5
208	R:R:S288	R:R:Y284	8.9	No	Yes	1	4	5
209	R:R:H290	R:R:Y286	15.24	No	No	0	2	4
210	R:R:D295	R:R:Y286	5.75	No	No	8	1	4
211	R:R:H300	R:R:Y286	4.36	Yes	No	8	4	4
212	R:R:E293	R:R:H290	7.39	No	No	0	5	2
213	R:R:E293	R:R:S292	4.31	No	No	0	5	1
214	R:R:D295	R:R:H300	6.3	No	Yes	8	1	4
215	R:R:F301	R:R:I305	6.28	Yes	No	2	4	4
216	R:R:C306	R:R:L310	3.17	No	Yes	0	4	8
217	R:R:F312	R:R:R308	5.34	Yes	No	2	7	5
218	R:R:F320	R:R:F333	5.36	No	Yes	0	5	7
219	R:R:F329	R:R:L322	3.65	No	No	0	9	9
220	R:R:R330	R:R:Y323	6.17	No	No	0	8	7
221	R:R:F333	R:R:Y323	10.32	Yes	No	0	7	7
222	R:R:N334	R:R:Y323	9.3	No	No	0	4	7
223	R:R:L325	R:R:S326	7.51	No	No	0	7	8
224	R:R:F329	R:R:F333	3.22	No	Yes	0	9	7
225	L:L:G24	R:R:R100	3	No	No	0	0	5
226	R:R:N203	R:R:S202	2.98	No	No	0	2	3
227	R:R:L262	R:R:V266	2.98	No	No	0	8	8
228	R:R:I305	R:R:I43	2.94	No	No	0	4	6
229	R:R:I221	R:R:I225	2.94	No	No	0	5	7
230	L:L:A22	R:R:H300	2.93	No	Yes	0	0	4
231	R:R:I64	R:R:M71	2.92	Yes	No	0	7	7
232	R:R:I256	R:R:K260	2.91	Yes	No	0	4	5
233	R:R:G48	R:R:Y47	2.9	No	Yes	0	4	7
234	R:R:I142	R:R:L237	2.85	No	Yes	5	8	8
235	R:R:I166	R:R:L170	2.85	No	No	0	5	4
236	R:R:I167	R:R:L171	2.85	No	No	0	4	6
237	R:R:I233	R:R:L237	2.85	No	Yes	5	8	8
238	R:R:L216	R:R:M212	2.83	No	No	0	4	4
239	R:R:L237	R:R:L262	2.77	Yes	No	0	8	8
240	R:R:A321	R:R:F269	2.77	No	No	0	8	7
241	R:R:H185	R:R:T192	2.74	No	No	0	2	4
242	R:R:L244	R:R:Q255	2.66	No	No	0	5	3
243	R:R:R259	R:R:S240	2.64	No	No	0	7	6
244	L:L:A22	L:L:W21	2.59	No	Yes	0	0	0
245	R:R:S304	R:R:Y101	2.54	No	Yes	0	4	4
246	R:R:I148	R:R:R144	2.51	No	No	0	6	6
247	R:R:S99	R:R:W106	2.47	No	Yes	0	4	8
248	R:R:F65	R:R:N76	2.42	No	No	0	7	8
249	R:R:M212	R:R:Y289	2.39	No	No	0	4	5
250	R:R:D147	R:R:R144	2.38	No	No	0	5	6
251	R:R:F232	R:R:Y231	2.06	No	No	0	3	3
252	R:R:A94	R:R:P95	1.87	No	No	0	7	9
253	R:R:A307	R:R:P279	1.87	No	No	0	6	9
254	R:R:G85	R:R:S123	1.86	No	No	0	8	8
255	R:R:G271	R:R:V270	1.84	No	No	0	5	7
256	R:R:G57	R:R:I56	1.76	No	No	0	8	5
257	R:R:G112	R:R:I111	1.76	No	No	0	6	2
258	R:R:G112	R:R:I116	1.76	No	No	0	6	5
259	R:R:P183	R:R:T192	1.75	No	No	0	2	4
260	R:R:C113	R:R:S179	1.72	No	No	0	9	5
261	R:R:G85	R:R:L84	1.71	No	No	0	8	7
262	R:R:A45	R:R:V42	1.7	No	No	0	6	5
263	R:R:A153	R:R:V74	1.7	No	Yes	0	7	7
264	R:R:E247	R:R:G248	1.64	No	No	0	4	5
265	R:R:S227	R:R:V270	1.62	No	No	0	5	7
266	R:R:A241	R:R:I256	1.62	No	Yes	0	3	4
267	R:R:A136	R:R:K160	1.61	No	No	0	7	6
268	R:R:A274	R:R:L223	1.58	No	No	0	6	6
269	R:R:A263	R:R:L237	1.58	No	Yes	0	6	8
270	R:R:I53	R:R:V49	1.54	No	No	0	6	4
271	R:R:I283	R:R:V282	1.54	No	No	0	5	7
272	R:R:H182	R:R:P183	1.53	Yes	No	0	1	2
273	R:R:L299	R:R:S297	1.5	No	No	0	2	3
274	R:R:L309	R:R:V46	1.49	No	No	0	5	6
275	R:R:L154	R:R:V74	1.49	No	Yes	0	2	7
276	R:R:N243	R:R:S240	1.49	No	No	0	2	6
277	R:R:L272	R:R:V317	1.49	No	No	0	7	6
278	R:R:P145	R:R:R144	1.44	No	No	0	8	6
279	R:R:E204	R:R:S292	1.44	No	No	0	1	1
280	R:R:I59	R:R:L87	1.43	No	No	0	4	8
281	R:R:I91	R:R:L88	1.43	No	No	0	5	7
282	R:R:I173	R:R:L170	1.43	No	No	0	4	4
283	R:R:H300	R:R:S297	1.39	Yes	No	0	4	3
284	R:R:D137	R:R:K140	1.38	No	No	0	8	4
285	R:R:I64	R:R:Q332	1.37	Yes	No	0	7	6
286	R:R:L205	R:R:N203	1.37	No	No	0	1	2
287	R:R:E247	R:R:N249	1.31	No	No	0	4	5
288	R:R:R261	R:R:T265	1.29	No	No	0	8	8
289	R:R:F301	R:R:M298	1.24	Yes	No	0	4	3
290	R:R:K327	R:R:R330	1.24	No	No	0	4	8
291	R:R:F129	R:R:L171	1.22	Yes	No	0	5	6
292	R:R:F275	R:R:L310	1.22	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W21	10.714	5	2	0
2	L:L:M27	5.8475	4	0	0
3	R:R:Y47	6.51	5	2	7
4	R:R:I64	3.89	4	0	7
5	R:R:V74	2.4475	4	0	7
6	R:R:L82	7.5975	4	3	9
7	R:R:D86	6.896	5	3	9
8	R:R:Y101	6.66333	6	2	4
9	R:R:W106	7.838	5	0	8
10	R:R:T122	4.184	5	0	5
11	R:R:F129	3.9475	4	0	5
12	R:R:H182	6.58333	6	1	1
13	R:R:F184	8.405	4	1	2
14	R:R:F193	7.7575	4	1	1
15	R:R:Y199	8.16333	6	1	5
16	R:R:H206	5.428	5	0	1
17	R:R:F215	9.7575	4	6	6
18	R:R:F218	5.8475	4	0	6
19	R:R:Y230	8.042	5	4	8
20	R:R:L237	2.982	5	5	8
21	R:R:I256	3.298	5	7	4
22	R:R:C276	4.8	4	0	8
23	R:R:W277	11.5425	4	0	8
24	R:R:Y284	10.1525	4	1	5
25	R:R:Y291	7.02	4	1	1
26	R:R:H300	3.745	4	8	4
27	R:R:F301	8.69	4	2	4
28	R:R:L310	3.505	4	0	8
29	R:R:F312	5.3875	4	2	7
30	R:R:F333	6.995	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F108	R:R:W106	11.9553	12.03	No	Yes	0	7	8
2	R:R:F108	R:R:I116	13.2882	8.79	No	No	0	7	5
3	R:R:I116	R:R:P117	17.3603	5.08	No	No	0	5	5
4	L:L:H25	R:R:P117	22.6104	10.68	No	No	0	0	5
5	L:L:H25	R:R:P198	23.8821	19.83	No	No	0	0	4
6	R:R:P198	R:R:Y199	31.3578	5.56	No	Yes	0	4	5
7	R:R:Y199	R:R:Y284	51.5999	8.94	Yes	Yes	1	5	5
8	L:L:L26	R:R:Y284	64.5946	16.41	No	Yes	0	0	5
9	L:L:L26	L:L:M27	63.5308	5.65	No	Yes	0	0	0
10	L:L:M27	R:R:C93	51.4409	3.24	Yes	No	0	0	7
11	R:R:C93	R:R:F312	43.525	4.19	No	Yes	0	7	7
12	R:R:F312	R:R:R308	32.0344	5.34	Yes	No	2	7	5
13	R:R:R308	R:R:Y101	29.4379	9.26	No	Yes	2	5	4
14	L:L:W21	R:R:Y101	18.2244	6.75	Yes	Yes	2	0	4
15	R:R:Y199	R:R:Y291	40.9652	8.94	Yes	Yes	1	5	1
16	R:R:F184	R:R:Y291	15.7217	8.25	Yes	Yes	1	2	1
17	R:R:F184	R:R:F193	13.7121	11.79	Yes	Yes	1	2	1
18	R:R:S211	R:R:Y284	70.8841	6.36	No	Yes	1	5	5
19	R:R:L285	R:R:S211	100	4.5	No	No	0	5	5
20	R:R:F215	R:R:L285	99.7758	15.83	Yes	No	0	6	5
21	R:R:F215	R:R:H281	91.0121	7.92	Yes	No	6	6	7
22	R:R:H281	R:R:W277	96.3519	7.41	No	Yes	0	7	8
23	R:R:N314	R:R:W277	18.4853	15.82	No	Yes	0	9	8
24	R:R:C276	R:R:N314	17.0301	6.3	Yes	No	0	8	9
25	R:R:F273	R:R:W277	86.6262	18.04	No	Yes	0	9	8
26	R:R:F273	R:R:Q131	85.3789	11.71	No	No	0	9	9
27	R:R:L82	R:R:Q131	46.6311	3.99	Yes	No	3	9	9
28	R:R:D86	R:R:L82	60.1435	8.14	Yes	Yes	3	9	9
29	R:R:D86	R:R:N58	94.8641	6.73	Yes	No	0	9	9
30	R:R:N318	R:R:Q131	38.4625	9.24	No	No	3	9	9
31	R:R:D86	R:R:N318	37.9937	10.77	Yes	No	3	9	9
32	R:R:N58	R:R:P319	88.489	6.52	No	No	0	9	9
33	R:R:G57	R:R:P319	86.8748	4.06	No	No	0	8	9
34	R:R:F320	R:R:G57	83.6221	3.01	No	No	0	5	8
35	R:R:F320	R:R:F333	81.9794	5.36	No	Yes	0	5	7
36	R:R:F333	R:R:T60	63.4533	9.08	Yes	No	0	7	7
37	R:R:I64	R:R:T60	60.0375	3.04	Yes	No	0	7	7
38	R:R:F329	R:R:F333	11.8983	3.22	No	Yes	0	9	7
39	R:R:I64	R:R:M71	51.1923	2.92	Yes	No	0	7	7
40	R:R:M71	R:R:N76	45.7873	8.41	No	No	0	7	8
41	R:R:N73	R:R:N76	36.616	9.54	No	No	0	8	8
42	R:R:N73	R:R:P75	34.7573	11.4	No	No	0	8	8
43	R:R:P75	R:R:V74	32.8904	3.53	No	Yes	0	8	7
44	R:R:I157	R:R:V74	27.2409	3.07	No	Yes	0	7	7
45	R:R:F78	R:R:I157	23.4337	11.3	No	No	0	7	7
46	R:R:D137	R:R:F78	15.7502	13.14	No	No	0	8	7
47	R:R:E175	R:R:P198	20.609	4.72	No	No	0	5	4
48	R:R:E175	R:R:L121	37.7655	3.98	No	No	0	5	4
49	R:R:A172	R:R:L121	28.9651	4.73	No	No	0	7	4
50	R:R:A172	R:R:T122	28.5738	3.36	No	Yes	0	7	5
51	R:R:S168	R:R:T122	26.5928	4.8	No	Yes	0	8	5
52	R:R:S168	R:R:V126	31.3537	4.85	No	No	0	8	7
53	R:R:T130	R:R:V126	30.9542	3.17	No	No	0	8	7
54	R:R:H210	R:R:Y199	21.0166	11.98	No	Yes	0	6	5
55	R:R:E175	R:R:H210	19.3861	12.31	No	No	0	5	6
56	R:R:L82	R:R:T130	30.9868	5.9	Yes	No	0	9	8
57	R:R:L89	R:R:S123	13.5695	6.01	No	No	0	7	8
58	R:R:H182	R:R:Y291	20.128	4.36	Yes	Yes	1	1	1
59	R:R:V128	R:R:W277	68.0186	4.9	No	Yes	0	8	8
60	R:R:P222	R:R:V128	66.755	3.53	No	No	0	9	8
61	R:R:I221	R:R:P222	65.4832	3.39	No	No	0	5	9
62	R:R:I221	R:R:I225	64.2033	2.94	No	No	0	5	7
63	R:R:I225	R:R:Y229	62.9153	6.04	No	No	0	7	7
64	R:R:S135	R:R:Y229	52.3173	6.36	No	No	0	9	7
65	R:R:S135	R:R:Y230	47.9477	10.17	No	Yes	4	9	8
66	R:R:Y139	R:R:Y229	11.295	9.93	No	No	0	8	7
67	R:R:D137	R:R:K140	13.863	1.38	No	No	0	8	4
68	R:R:I148	R:R:K140	11.9064	10.18	No	No	0	6	4
69	R:R:V266	R:R:Y230	39.7709	8.83	No	Yes	0	8	8
70	R:R:L262	R:R:V266	38.3361	2.98	No	No	0	8	8
71	R:R:L237	R:R:L262	28.0724	2.77	Yes	No	0	8	8
72	R:R:H206	R:R:H210	12.3181	3.58	Yes	No	0	1	6
73	R:R:L278	R:R:Y219	11.9716	9.38	No	No	0	6	8
74	R:R:L237	R:R:R259	22.1131	4.86	Yes	No	0	8	7
75	R:R:Q255	R:R:R259	17.503	5.84	No	No	0	3	7
76	R:R:L244	R:R:Q255	15.9418	2.66	No	No	0	5	3
77	R:R:I256	R:R:L244	12.8602	4.28	Yes	No	0	4	5
78	R:R:L278	R:R:P279	10.4553	3.28	No	No	0	6	9
79	R:R:A307	R:R:P279	10.5124	1.87	No	No	0	6	9
80	L:L:A22	L:L:W21	14.4255	2.59	No	Yes	0	0	0
81	L:L:A22	R:R:H300	13.0192	2.93	No	Yes	0	0	4
82	R:R:S288	R:R:Y199	28.9691	3.82	No	Yes	1	4	5
83	R:R:S211	R:R:S288	29.3645	6.52	No	No	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N19	R:R:T296	13.16	2	No	No	0	3	0	1
L:L:H20	R:R:W106	3.17	0	No	Yes	0	8	0	1
L:L:H20	R:R:S195	6.97	0	No	No	0	4	0	1
L:L:W21	R:R:Y101	6.75	2	Yes	Yes	0	4	0	1
L:L:W21	R:R:T296	8.49	2	Yes	No	0	3	0	1
L:L:W21	R:R:F301	21.05	2	Yes	Yes	0	4	0	1
L:L:V23	R:R:F193	7.87	0	No	Yes	0	1	0	1
L:L:G24	R:R:R287	4.5	0	No	No	0	4	0	1
L:L:H25	R:R:P117	10.68	0	No	No	0	5	0	1
L:L:H25	R:R:P198	19.83	0	No	No	0	4	0	1
L:L:L26	R:R:Y284	16.41	0	No	Yes	0	5	0	1
L:L:M27	R:R:C93	3.24	0	Yes	No	0	7	0	1
L:L:M27	R:R:V124	6.09	0	Yes	No	0	7	0	1
L:L:M27	R:R:N280	8.41	0	Yes	No	0	5	0	1
R:R:C93	R:R:L89	4.76	0	No	No	7	7	1	2
R:R:L89	R:R:V124	5.96	0	No	No	7	7	2	1
R:R:C93	R:R:F312	4.19	0	No	Yes	7	7	1	2
R:R:D97	R:R:Y101	9.2	2	No	Yes	6	4	2	1
R:R:D97	R:R:R308	11.91	2	No	No	6	5	2	2
R:R:R100	R:R:W106	14.99	0	No	Yes	5	8	1	1
R:R:R100	R:R:S195	5.27	0	No	No	5	4	1	1
R:R:F301	R:R:Y101	6.19	2	Yes	Yes	4	4	1	1
R:R:I305	R:R:Y101	6.04	2	No	Yes	4	4	2	1
R:R:R308	R:R:Y101	9.26	2	No	Yes	5	4	2	1
R:R:F108	R:R:W106	12.03	0	No	Yes	7	8	2	1
R:R:C196	R:R:W106	6.53	0	No	Yes	9	8	2	1
R:R:F108	R:R:I116	8.79	0	No	No	7	5	2	2
R:R:I116	R:R:P117	5.08	0	No	No	5	5	2	1
R:R:P117	R:R:Q120	3.16	0	No	No	5	6	1	2
R:R:E175	R:R:P198	4.72	0	No	No	5	4	2	1
R:R:F184	R:R:F193	11.79	1	Yes	Yes	2	1	2	1
R:R:E186	R:R:F193	3.5	1	No	Yes	3	1	2	1
R:R:E186	R:R:V294	5.7	1	No	No	3	5	2	2
R:R:F193	R:R:V294	7.87	1	Yes	No	1	5	1	2
R:R:P198	R:R:Y199	5.56	0	No	Yes	4	5	1	2
R:R:Y199	R:R:Y284	8.94	1	Yes	Yes	5	5	2	1
R:R:S288	R:R:Y199	3.82	1	No	Yes	4	5	2	2
R:R:S211	R:R:Y284	6.36	1	No	Yes	5	5	2	1
R:R:S211	R:R:S288	6.52	1	No	No	5	4	2	2
R:R:A311	R:R:N280	4.69	0	No	No	8	5	2	1
R:R:S288	R:R:Y284	8.9	1	No	Yes	4	5	2	1
R:R:D295	R:R:Y286	5.75	8	No	No	1	4	2	2
R:R:H300	R:R:Y286	4.36	8	Yes	No	4	4	1	2
R:R:D295	R:R:H300	6.3	8	No	Yes	1	4	2	1
R:R:F301	R:R:I305	6.28	2	Yes	No	4	4	1	2
R:R:F312	R:R:R308	5.34	2	Yes	No	7	5	2	2
L:L:G24	R:R:R100	3	0	No	No	0	5	0	1
L:L:A22	R:R:H300	2.93	0	No	Yes	0	4	0	1
R:R:S304	R:R:Y101	2.54	0	No	Yes	4	4	2	1
R:R:S99	R:R:W106	2.47	0	No	Yes	4	8	2	1
R:R:H300	R:R:S297	1.39	8	Yes	No	4	3	1	2
R:R:F301	R:R:M298	1.24	2	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H0Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	268
Number of Links	292
Number of Hubs	30
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	41
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	57727
Length Of Smallest Path	3
Average Path Length	18.1316
Length of Longest Path	45
Minimum Path Strength	1.445
Average Path Strength	6.80508
Maximum Path Strength	17.87
Minimum Path Correlation	0.7
Average Path Correlation	0.937333
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	50.763
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.9741
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • regulation of potassium ion transport • negative regulation of ion transmembrane transporter activity • negative regulation of potassium ion transmembrane transporter activity • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • potassium ion transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • metal ion transport • negative regulation of transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of voltage-gated potassium channel activity • monoatomic ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of metal ion transport • negative regulation of potassium ion transport • regulation of monoatomic ion transport • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of potassium ion transmembrane transport • regulation of potassium ion transmembrane transport • transmembrane transport • regulation of transmembrane transport • potassium ion transport • regulation of monoatomic cation transmembrane transport • neuropeptide signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • establishment of organelle localization • regulated exocytosis • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • organelle localization • leukocyte activation involved in immune response • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • vacuolar localization • mast cell degranulation • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • lysosome localization • behavior • biological process involved in intraspecies interaction between organisms • social behavior • psychomotor behavior • motor behavior • response to external biotic stimulus • response to biotic stimulus • regulation of fear response • regulation of behavioral fear response • regulation of behavior • behavioral defense response • behavioral fear response • positive regulation of behavioral fear response • multicellular organismal response to stress • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of respiratory gaseous exchange • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • positive regulation of peptide hormone secretion • positive regulation of transport • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • learning or memory • regulation of cell population proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30550
Sequence	>8H0Q_nogp_Chain_R V I P A V Y G V I I L I G L I G N I T L I K I F C T V K S M R N V P N L F I S S L A L G D L L L L I T C A P V D A S R Y L A D R W L F G R I G C K L I P F I Q L T S V G V S V F T Q T A L S A D R Y K A I V R P M D I Q A S H A L M K I C L K A A F I W I I S M L L A I P E A V F S D L H P F H E Q T F I S C A P Y P H S N E L H P K I H S M A S F L V F Y V I P L S I I S V Y Y Y F I A K N L I Q S A Y N L P V E G N I H V K K Q I E S R K R L A K T V L V F V G L F A F C W L P N H V I Y L Y R S Y H Y S E V D T S M L H F V T S I C A R L L A F T N S C V N P F A L Y L L S K S F R K Q F N T Q L L C C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H0Q	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.3	2023-08-09	doi.org/10.1038/s41422-022-00743-6
	8H0Q (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-		3.3	2023-08-09	doi.org/10.1038/s41422-022-00743-6
	7W3Z	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-	chim(NtGi1L-Gq)/β1/γ2	3	2023-02-22	doi.org/10.1073/pnas.2216230120
	7W3Z (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-		3	2023-02-22	doi.org/10.1073/pnas.2216230120
	7W40	A	Peptide	Bombesin	BB₂	Homo sapiens	Bombesin	-	chim(NtGi1L-Gq)/β1/γ2	3	2023-02-22	doi.org/10.1073/pnas.2216230120
	7W40 (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Bombesin	-		3	2023-02-22	doi.org/10.1073/pnas.2216230120
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	doi.org/10.1073/pnas.2216230120

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