psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N19	L:L:W21	14.69	No	Yes	2	0	0
2	L:L:N19	R:R:T296	13.16	No	No	2	0	3
3	L:L:H20	R:R:W106	3.17	No	Yes	0	0	8
4	L:L:H20	R:R:S195	6.97	No	No	0	0	4
5	L:L:W21	R:R:Y101	6.75	Yes	Yes	2	0	4
6	L:L:W21	R:R:T296	8.49	Yes	No	2	0	3
7	L:L:W21	R:R:F301	21.05	Yes	Yes	2	0	4
8	L:L:V23	R:R:F193	7.87	No	Yes	0	0	1
9	L:L:G24	R:R:R287	4.5	No	No	0	0	4
10	L:L:H25	R:R:P117	10.68	No	No	0	0	5
11	L:L:H25	R:R:P198	19.83	No	No	0	0	4
12	L:L:L26	L:L:M27	5.65	No	Yes	0	0	0
13	L:L:L26	R:R:Y284	16.41	No	Yes	0	0	5
14	L:L:M27	R:R:C93	3.24	Yes	No	0	0	7
15	L:L:M27	R:R:V124	6.09	Yes	No	0	0	7
16	L:L:M27	R:R:N280	8.41	Yes	No	0	0	5
17	R:R:P44	R:R:V42	8.84	No	No	0	6	5
18	R:R:I43	R:R:P44	3.39	No	No	0	6	6
19	R:R:I51	R:R:Y47	12.09	No	Yes	2	7	7
20	R:R:D97	R:R:Y47	3.45	No	Yes	2	6	7
21	R:R:L309	R:R:Y47	5.86	No	Yes	0	5	7
22	R:R:F312	R:R:Y47	8.25	Yes	Yes	2	7	7
23	R:R:I50	R:R:T313	3.04	No	No	0	7	5
24	R:R:C316	R:R:I50	6.55	No	No	0	7	7
25	R:R:A94	R:R:I51	3.25	No	No	0	7	7
26	R:R:F312	R:R:I51	3.77	Yes	No	2	7	7
27	R:R:G54	R:R:I53	3.53	No	No	0	8	6
28	R:R:C316	R:R:G54	3.92	No	No	0	7	8
29	R:R:I59	R:R:L55	4.28	No	No	0	4	6
30	R:R:G57	R:R:P319	4.06	No	No	0	8	9
31	R:R:F320	R:R:G57	3.01	No	No	0	5	8
32	R:R:D86	R:R:N58	6.73	Yes	No	0	9	9
33	R:R:L87	R:R:N58	5.49	No	No	0	8	9
34	R:R:N58	R:R:P319	6.52	No	No	0	9	9
35	R:R:I64	R:R:T60	3.04	Yes	No	0	7	7
36	R:R:F333	R:R:T60	9.08	Yes	No	0	7	7
37	R:R:L337	R:R:T60	8.84	No	No	0	7	7
38	R:R:I79	R:R:L61	4.28	No	No	0	8	9
39	R:R:A83	R:R:L61	6.3	No	No	0	9	9
40	R:R:A83	R:R:I62	3.25	No	No	0	9	7
41	R:R:K63	R:R:Q336	10.85	No	No	0	4	5
42	R:R:I64	R:R:Q336	8.23	Yes	No	0	7	5
43	R:R:F65	R:R:R72	5.34	No	No	0	7	7
44	R:R:F65	R:R:S80	18.5	No	No	0	7	5
45	R:R:Q336	R:R:T67	5.67	No	No	0	5	5
46	R:R:S70	R:R:V68	4.85	No	No	0	6	6
47	R:R:K69	R:R:R72	11.14	No	No	0	5	7
48	R:R:M71	R:R:S70	3.07	No	No	0	7	6
49	R:R:M71	R:R:N76	8.41	No	No	0	7	8
50	R:R:N73	R:R:P75	11.4	No	No	0	8	8
51	R:R:N73	R:R:N76	9.54	No	No	0	8	8
52	R:R:P75	R:R:V74	3.53	No	Yes	0	8	7
53	R:R:I157	R:R:V74	3.07	No	Yes	0	7	7
54	R:R:I157	R:R:L77	5.71	No	No	0	7	6
55	R:R:D137	R:R:F78	13.14	No	No	0	8	7
56	R:R:F78	R:R:I157	11.3	No	No	0	7	7
57	R:R:F78	R:R:K160	6.2	No	No	0	7	6
58	R:R:I79	R:R:L322	7.14	No	No	0	8	9
59	R:R:S81	R:R:T130	6.4	No	No	0	9	8
60	R:R:D86	R:R:L82	8.14	Yes	Yes	3	9	9
61	R:R:L82	R:R:T130	5.9	Yes	No	0	9	8
62	R:R:L82	R:R:Q131	3.99	Yes	No	3	9	9
63	R:R:L82	R:R:N318	12.36	Yes	No	3	9	9
64	R:R:D86	R:R:S127	4.42	Yes	No	0	9	9
65	R:R:D86	R:R:S315	4.42	Yes	No	0	9	8
66	R:R:D86	R:R:N318	10.77	Yes	No	3	9	9
67	R:R:L88	R:R:S123	9.01	No	No	0	7	8
68	R:R:C93	R:R:L89	4.76	No	No	0	7	7
69	R:R:L89	R:R:S123	6.01	No	No	0	7	8
70	R:R:L89	R:R:V124	5.96	No	No	0	7	7
71	R:R:L90	R:R:S315	4.5	No	No	0	6	8
72	R:R:C316	R:R:L90	3.17	No	No	0	7	6
73	R:R:Q120	R:R:T92	9.92	No	No	0	6	5
74	R:R:C93	R:R:F312	4.19	No	Yes	0	7	7
75	R:R:Q120	R:R:V96	4.3	No	No	0	6	6
76	R:R:D97	R:R:Y101	9.2	No	Yes	2	6	4
77	R:R:D97	R:R:R308	11.91	No	No	2	6	5
78	R:R:R100	R:R:W106	14.99	No	Yes	0	5	8
79	R:R:R100	R:R:S195	5.27	No	No	0	5	4
80	R:R:F301	R:R:Y101	6.19	Yes	Yes	2	4	4
81	R:R:I305	R:R:Y101	6.04	No	Yes	2	4	4
82	R:R:R308	R:R:Y101	9.26	No	Yes	2	5	4
83	R:R:F108	R:R:W106	12.03	No	Yes	0	7	8
84	R:R:C196	R:R:W106	6.53	No	Yes	0	9	8
85	R:R:F108	R:R:I116	8.79	No	No	0	7	5
86	R:R:K114	R:R:R110	9.9	No	No	0	7	4
87	R:R:D180	R:R:R110	3.57	No	No	0	4	4
88	R:R:L181	R:R:R110	6.07	No	No	0	4	4
89	R:R:C113	R:R:L181	4.76	No	No	0	9	4
90	R:R:C113	R:R:C196	7.28	No	No	0	9	9
91	R:R:I116	R:R:P117	5.08	No	No	0	5	5
92	R:R:P117	R:R:Q120	3.16	No	No	0	5	6
93	R:R:F118	R:R:T122	5.19	No	Yes	0	6	5
94	R:R:F118	R:R:I173	3.77	No	No	0	6	4
95	R:R:A176	R:R:F118	4.16	No	No	0	5	6
96	R:R:I119	R:R:T122	4.56	No	Yes	0	5	5
97	R:R:A172	R:R:L121	4.73	No	No	0	7	4
98	R:R:E175	R:R:L121	3.98	No	No	0	5	4
99	R:R:F218	R:R:L121	8.53	Yes	No	0	6	4
100	R:R:S168	R:R:T122	4.8	No	Yes	0	8	5
101	R:R:M169	R:R:T122	3.01	No	Yes	0	4	5
102	R:R:A172	R:R:T122	3.36	No	Yes	0	7	5
103	R:R:F129	R:R:G125	3.01	Yes	No	0	5	6
104	R:R:F218	R:R:G125	3.01	Yes	No	0	6	6
105	R:R:T130	R:R:V126	3.17	No	No	0	8	7
106	R:R:V126	R:R:W165	17.16	No	No	0	7	9
107	R:R:S168	R:R:V126	4.85	No	No	0	8	7
108	R:R:P222	R:R:V128	3.53	No	No	0	9	8
109	R:R:V128	R:R:W277	4.9	No	Yes	0	8	8
110	R:R:F129	R:R:I164	6.28	Yes	No	0	5	7
111	R:R:F129	R:R:S168	5.28	Yes	No	0	5	8
112	R:R:F273	R:R:Q131	11.71	No	No	0	9	9
113	R:R:N318	R:R:Q131	9.24	No	No	3	9	9
114	R:R:I226	R:R:T132	7.6	No	No	0	8	7
115	R:R:A133	R:R:K160	3.21	No	No	0	7	6
116	R:R:L134	R:R:R138	8.5	No	No	0	9	9
117	R:R:I226	R:R:S135	3.1	No	No	4	8	9
118	R:R:S135	R:R:Y229	6.36	No	No	0	9	7
119	R:R:S135	R:R:Y230	10.17	No	Yes	4	9	8
120	R:R:R138	R:R:Y230	11.32	No	Yes	0	9	8
121	R:R:V143	R:R:Y139	16.4	No	No	0	7	8
122	R:R:Y139	R:R:Y229	9.93	No	No	0	8	7
123	R:R:F232	R:R:Y139	4.13	No	No	0	3	8
124	R:R:I148	R:R:K140	10.18	No	No	0	6	4
125	R:R:I142	R:R:I233	4.42	No	No	5	8	8
126	R:R:N236	R:R:V143	7.39	No	No	0	5	7
127	R:R:M146	R:R:P145	3.35	No	No	0	5	8
128	R:R:M146	R:R:Q149	5.44	No	No	0	5	5
129	R:R:H152	R:R:M155	7.88	No	No	0	7	3
130	R:R:F163	R:R:I167	11.3	No	No	0	3	4
131	R:R:I173	R:R:P174	3.39	No	No	0	4	7
132	R:R:E175	R:R:P198	4.72	No	No	0	5	4
133	R:R:E175	R:R:H210	12.31	No	No	0	5	6
134	R:R:F178	R:R:V177	5.24	No	No	0	5	4
135	R:R:F178	R:R:H206	9.05	No	Yes	0	5	1
136	R:R:D180	R:R:H182	11.35	No	Yes	0	4	1
137	R:R:D180	R:R:P200	4.83	No	No	0	4	5
138	R:R:I194	R:R:L181	8.56	No	No	0	4	4
139	R:R:F184	R:R:H182	5.66	Yes	Yes	1	2	1
140	R:R:A197	R:R:H182	5.85	No	Yes	0	1	1
141	R:R:H182	R:R:H201	10.75	Yes	No	1	1	3
142	R:R:H182	R:R:Y291	4.36	Yes	Yes	1	1	1
143	R:R:F184	R:R:F193	11.79	Yes	Yes	1	2	1
144	R:R:F184	R:R:H201	7.92	Yes	No	1	2	3
145	R:R:F184	R:R:Y291	8.25	Yes	Yes	1	2	1
146	R:R:E186	R:R:Q191	3.82	No	No	0	3	2
147	R:R:E186	R:R:F193	3.5	No	Yes	1	3	1
148	R:R:E186	R:R:V294	5.7	No	No	1	3	5
149	R:R:F193	R:R:V294	7.87	Yes	No	1	1	5
150	R:R:P198	R:R:Y199	5.56	No	Yes	0	4	5
151	R:R:P207	R:R:Y199	9.74	No	Yes	0	3	5
152	R:R:H210	R:R:Y199	11.98	No	Yes	0	6	5
153	R:R:Y199	R:R:Y284	8.94	Yes	Yes	1	5	5
154	R:R:S288	R:R:Y199	3.82	No	Yes	1	4	5
155	R:R:Y199	R:R:Y291	8.94	Yes	Yes	1	5	1
156	R:R:H206	R:R:P200	6.1	Yes	No	0	1	5
157	R:R:H201	R:R:Y291	6.53	No	Yes	1	3	1
158	R:R:H206	R:R:N203	3.83	Yes	No	0	1	2
159	R:R:H206	R:R:P207	4.58	Yes	No	0	1	3
160	R:R:H206	R:R:H210	3.58	Yes	No	0	1	6
161	R:R:K208	R:R:Y289	9.55	No	No	0	3	5
162	R:R:S211	R:R:Y284	6.36	No	Yes	1	5	5
163	R:R:L285	R:R:S211	4.5	No	No	0	5	5
164	R:R:S211	R:R:S288	6.52	No	No	1	5	4
165	R:R:F218	R:R:S214	6.61	Yes	No	0	6	6
166	R:R:F215	R:R:Y219	11.35	Yes	No	6	6	8
167	R:R:F215	R:R:V220	3.93	Yes	No	0	6	5
168	R:R:F215	R:R:H281	7.92	Yes	No	6	6	7
169	R:R:F215	R:R:L285	15.83	Yes	No	0	6	5
170	R:R:L216	R:R:V220	5.96	No	No	0	4	5
171	R:R:F218	R:R:V217	5.24	Yes	No	0	6	5
172	R:R:L278	R:R:Y219	9.38	No	No	0	6	8
173	R:R:H281	R:R:Y219	19.6	No	No	6	7	8
174	R:R:I221	R:R:P222	3.39	No	No	0	5	9
175	R:R:F273	R:R:L223	6.09	No	No	0	9	6
176	R:R:I225	R:R:Y229	6.04	No	No	0	7	7
177	R:R:I226	R:R:Y230	4.84	No	Yes	4	8	8
178	R:R:F232	R:R:V228	3.93	No	No	0	3	4
179	R:R:V266	R:R:Y230	8.83	No	Yes	0	8	8
180	R:R:V270	R:R:Y230	5.05	No	Yes	0	7	8
181	R:R:K235	R:R:N236	4.2	No	No	0	3	5
182	R:R:L237	R:R:R259	4.86	Yes	No	0	8	7
183	R:R:I238	R:R:Y242	3.63	No	No	0	4	3
184	R:R:L244	R:R:P245	4.93	No	No	0	5	3
185	R:R:I256	R:R:L244	4.28	Yes	No	0	4	5
186	R:R:V246	R:R:V252	3.21	No	No	7	3	3
187	R:R:I256	R:R:V246	4.61	Yes	No	7	4	3
188	R:R:N249	R:R:V252	4.43	No	No	0	5	3
189	R:R:H251	R:R:I250	6.63	No	No	0	3	2
190	R:R:I256	R:R:V252	3.07	Yes	No	7	4	3
191	R:R:E257	R:R:K253	4.05	No	No	0	4	4
192	R:R:Q255	R:R:R259	5.84	No	No	0	3	7
193	R:R:L262	R:R:L325	5.54	No	No	0	8	7
194	R:R:F269	R:R:T265	5.19	No	No	0	7	8
195	R:R:L325	R:R:T265	5.9	No	No	0	7	8
196	R:R:C276	R:R:L272	3.17	Yes	No	0	8	7
197	R:R:F273	R:R:W277	18.04	No	Yes	0	9	8
198	R:R:C276	R:R:L310	6.35	Yes	Yes	0	8	8
199	R:R:C276	R:R:T313	3.38	Yes	No	0	8	5
200	R:R:C276	R:R:N314	6.3	Yes	No	0	8	9
201	R:R:H281	R:R:W277	7.41	No	Yes	0	7	8
202	R:R:N314	R:R:W277	15.82	No	Yes	0	9	8
203	R:R:L278	R:R:P279	3.28	No	No	0	6	9
204	R:R:L310	R:R:P279	3.28	Yes	No	0	8	9
205	R:R:A311	R:R:N280	4.69	No	No	0	8	5
206	R:R:I283	R:R:T303	6.08	No	No	0	5	4
207	R:R:A307	R:R:I283	3.25	No	No	0	6	5
208	R:R:S288	R:R:Y284	8.9	No	Yes	1	4	5
209	R:R:H290	R:R:Y286	15.24	No	No	0	2	4
210	R:R:D295	R:R:Y286	5.75	No	No	8	1	4
211	R:R:H300	R:R:Y286	4.36	Yes	No	8	4	4
212	R:R:E293	R:R:H290	7.39	No	No	0	5	2
213	R:R:E293	R:R:S292	4.31	No	No	0	5	1
214	R:R:D295	R:R:H300	6.3	No	Yes	8	1	4
215	R:R:F301	R:R:I305	6.28	Yes	No	2	4	4
216	R:R:C306	R:R:L310	3.17	No	Yes	0	4	8
217	R:R:F312	R:R:R308	5.34	Yes	No	2	7	5
218	R:R:F320	R:R:F333	5.36	No	Yes	0	5	7
219	R:R:F329	R:R:L322	3.65	No	No	0	9	9
220	R:R:R330	R:R:Y323	6.17	No	No	0	8	7
221	R:R:F333	R:R:Y323	10.32	Yes	No	0	7	7
222	R:R:N334	R:R:Y323	9.3	No	No	0	4	7
223	R:R:L325	R:R:S326	7.51	No	No	0	7	8
224	R:R:F329	R:R:F333	3.22	No	Yes	0	9	7
225	L:L:G24	R:R:R100	3	No	No	0	0	5
226	R:R:N203	R:R:S202	2.98	No	No	0	2	3
227	R:R:L262	R:R:V266	2.98	No	No	0	8	8
228	R:R:I305	R:R:I43	2.94	No	No	0	4	6
229	R:R:I221	R:R:I225	2.94	No	No	0	5	7
230	L:L:A22	R:R:H300	2.93	No	Yes	0	0	4
231	R:R:I64	R:R:M71	2.92	Yes	No	0	7	7
232	R:R:I256	R:R:K260	2.91	Yes	No	0	4	5
233	R:R:G48	R:R:Y47	2.9	No	Yes	0	4	7
234	R:R:I142	R:R:L237	2.85	No	Yes	5	8	8
235	R:R:I166	R:R:L170	2.85	No	No	0	5	4
236	R:R:I167	R:R:L171	2.85	No	No	0	4	6
237	R:R:I233	R:R:L237	2.85	No	Yes	5	8	8
238	R:R:L216	R:R:M212	2.83	No	No	0	4	4
239	R:R:L237	R:R:L262	2.77	Yes	No	0	8	8
240	R:R:A321	R:R:F269	2.77	No	No	0	8	7
241	R:R:H185	R:R:T192	2.74	No	No	0	2	4
242	R:R:L244	R:R:Q255	2.66	No	No	0	5	3
243	R:R:R259	R:R:S240	2.64	No	No	0	7	6
244	L:L:A22	L:L:W21	2.59	No	Yes	0	0	0
245	R:R:S304	R:R:Y101	2.54	No	Yes	0	4	4
246	R:R:I148	R:R:R144	2.51	No	No	0	6	6
247	R:R:S99	R:R:W106	2.47	No	Yes	0	4	8
248	R:R:F65	R:R:N76	2.42	No	No	0	7	8
249	R:R:M212	R:R:Y289	2.39	No	No	0	4	5
250	R:R:D147	R:R:R144	2.38	No	No	0	5	6
251	R:R:F232	R:R:Y231	2.06	No	No	0	3	3
252	R:R:A94	R:R:P95	1.87	No	No	0	7	9
253	R:R:A307	R:R:P279	1.87	No	No	0	6	9
254	R:R:G85	R:R:S123	1.86	No	No	0	8	8
255	R:R:G271	R:R:V270	1.84	No	No	0	5	7
256	R:R:G57	R:R:I56	1.76	No	No	0	8	5
257	R:R:G112	R:R:I111	1.76	No	No	0	6	2
258	R:R:G112	R:R:I116	1.76	No	No	0	6	5
259	R:R:P183	R:R:T192	1.75	No	No	0	2	4
260	R:R:C113	R:R:S179	1.72	No	No	0	9	5
261	R:R:G85	R:R:L84	1.71	No	No	0	8	7
262	R:R:A45	R:R:V42	1.7	No	No	0	6	5
263	R:R:A153	R:R:V74	1.7	No	Yes	0	7	7
264	R:R:E247	R:R:G248	1.64	No	No	0	4	5
265	R:R:S227	R:R:V270	1.62	No	No	0	5	7
266	R:R:A241	R:R:I256	1.62	No	Yes	0	3	4
267	R:R:A136	R:R:K160	1.61	No	No	0	7	6
268	R:R:A274	R:R:L223	1.58	No	No	0	6	6
269	R:R:A263	R:R:L237	1.58	No	Yes	0	6	8
270	R:R:I53	R:R:V49	1.54	No	No	0	6	4
271	R:R:I283	R:R:V282	1.54	No	No	0	5	7
272	R:R:H182	R:R:P183	1.53	Yes	No	0	1	2
273	R:R:L299	R:R:S297	1.5	No	No	0	2	3
274	R:R:L309	R:R:V46	1.49	No	No	0	5	6
275	R:R:L154	R:R:V74	1.49	No	Yes	0	2	7
276	R:R:N243	R:R:S240	1.49	No	No	0	2	6
277	R:R:L272	R:R:V317	1.49	No	No	0	7	6
278	R:R:P145	R:R:R144	1.44	No	No	0	8	6
279	R:R:E204	R:R:S292	1.44	No	No	0	1	1
280	R:R:I59	R:R:L87	1.43	No	No	0	4	8
281	R:R:I91	R:R:L88	1.43	No	No	0	5	7
282	R:R:I173	R:R:L170	1.43	No	No	0	4	4
283	R:R:H300	R:R:S297	1.39	Yes	No	0	4	3
284	R:R:D137	R:R:K140	1.38	No	No	0	8	4
285	R:R:I64	R:R:Q332	1.37	Yes	No	0	7	6
286	R:R:L205	R:R:N203	1.37	No	No	0	1	2
287	R:R:E247	R:R:N249	1.31	No	No	0	4	5
288	R:R:R261	R:R:T265	1.29	No	No	0	8	8
289	R:R:F301	R:R:M298	1.24	Yes	No	0	4	3
290	R:R:K327	R:R:R330	1.24	No	No	0	4	8
291	R:R:F129	R:R:L171	1.22	Yes	No	0	5	6
292	R:R:F275	R:R:L310	1.22	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W21	10.714	5	2	0
2	L:L:M27	5.8475	4	0	0
3	R:R:Y47	6.51	5	2	7
4	R:R:I64	3.89	4	0	7
5	R:R:V74	2.4475	4	0	7
6	R:R:L82	7.5975	4	3	9
7	R:R:D86	6.896	5	3	9
8	R:R:Y101	6.66333	6	2	4
9	R:R:W106	7.838	5	0	8
10	R:R:T122	4.184	5	0	5
11	R:R:F129	3.9475	4	0	5
12	R:R:H182	6.58333	6	1	1
13	R:R:F184	8.405	4	1	2
14	R:R:F193	7.7575	4	1	1
15	R:R:Y199	8.16333	6	1	5
16	R:R:H206	5.428	5	0	1
17	R:R:F215	9.7575	4	6	6
18	R:R:F218	5.8475	4	0	6
19	R:R:Y230	8.042	5	4	8
20	R:R:L237	2.982	5	5	8
21	R:R:I256	3.298	5	7	4
22	R:R:C276	4.8	4	0	8
23	R:R:W277	11.5425	4	0	8
24	R:R:Y284	10.1525	4	1	5
25	R:R:Y291	7.02	4	1	1
26	R:R:H300	3.745	4	8	4
27	R:R:F301	8.69	4	2	4
28	R:R:L310	3.505	4	0	8
29	R:R:F312	5.3875	4	2	7
30	R:R:F333	6.995	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F108	R:R:W106	11.9553	12.03	No	Yes	0	7	8
2	R:R:F108	R:R:I116	13.2882	8.79	No	No	0	7	5
3	R:R:I116	R:R:P117	17.3603	5.08	No	No	0	5	5
4	L:L:H25	R:R:P117	22.6104	10.68	No	No	0	0	5
5	L:L:H25	R:R:P198	23.8821	19.83	No	No	0	0	4
6	R:R:P198	R:R:Y199	31.3578	5.56	No	Yes	0	4	5
7	R:R:Y199	R:R:Y284	51.5999	8.94	Yes	Yes	1	5	5
8	L:L:L26	R:R:Y284	64.5946	16.41	No	Yes	0	0	5
9	L:L:L26	L:L:M27	63.5308	5.65	No	Yes	0	0	0
10	L:L:M27	R:R:C93	51.4409	3.24	Yes	No	0	0	7
11	R:R:C93	R:R:F312	43.525	4.19	No	Yes	0	7	7
12	R:R:F312	R:R:R308	32.0344	5.34	Yes	No	2	7	5
13	R:R:R308	R:R:Y101	29.4379	9.26	No	Yes	2	5	4
14	L:L:W21	R:R:Y101	18.2244	6.75	Yes	Yes	2	0	4
15	R:R:Y199	R:R:Y291	40.9652	8.94	Yes	Yes	1	5	1
16	R:R:F184	R:R:Y291	15.7217	8.25	Yes	Yes	1	2	1
17	R:R:F184	R:R:F193	13.7121	11.79	Yes	Yes	1	2	1
18	R:R:S211	R:R:Y284	70.8841	6.36	No	Yes	1	5	5
19	R:R:L285	R:R:S211	100	4.5	No	No	0	5	5
20	R:R:F215	R:R:L285	99.7758	15.83	Yes	No	0	6	5
21	R:R:F215	R:R:H281	91.0121	7.92	Yes	No	6	6	7
22	R:R:H281	R:R:W277	96.3519	7.41	No	Yes	0	7	8
23	R:R:N314	R:R:W277	18.4853	15.82	No	Yes	0	9	8
24	R:R:C276	R:R:N314	17.0301	6.3	Yes	No	0	8	9
25	R:R:F273	R:R:W277	86.6262	18.04	No	Yes	0	9	8
26	R:R:F273	R:R:Q131	85.3789	11.71	No	No	0	9	9
27	R:R:L82	R:R:Q131	46.6311	3.99	Yes	No	3	9	9
28	R:R:D86	R:R:L82	60.1435	8.14	Yes	Yes	3	9	9
29	R:R:D86	R:R:N58	94.8641	6.73	Yes	No	0	9	9
30	R:R:N318	R:R:Q131	38.4625	9.24	No	No	3	9	9
31	R:R:D86	R:R:N318	37.9937	10.77	Yes	No	3	9	9
32	R:R:N58	R:R:P319	88.489	6.52	No	No	0	9	9
33	R:R:G57	R:R:P319	86.8748	4.06	No	No	0	8	9
34	R:R:F320	R:R:G57	83.6221	3.01	No	No	0	5	8
35	R:R:F320	R:R:F333	81.9794	5.36	No	Yes	0	5	7
36	R:R:F333	R:R:T60	63.4533	9.08	Yes	No	0	7	7
37	R:R:I64	R:R:T60	60.0375	3.04	Yes	No	0	7	7
38	R:R:F329	R:R:F333	11.8983	3.22	No	Yes	0	9	7
39	R:R:I64	R:R:M71	51.1923	2.92	Yes	No	0	7	7
40	R:R:M71	R:R:N76	45.7873	8.41	No	No	0	7	8
41	R:R:N73	R:R:N76	36.616	9.54	No	No	0	8	8
42	R:R:N73	R:R:P75	34.7573	11.4	No	No	0	8	8
43	R:R:P75	R:R:V74	32.8904	3.53	No	Yes	0	8	7
44	R:R:I157	R:R:V74	27.2409	3.07	No	Yes	0	7	7
45	R:R:F78	R:R:I157	23.4337	11.3	No	No	0	7	7
46	R:R:D137	R:R:F78	15.7502	13.14	No	No	0	8	7
47	R:R:E175	R:R:P198	20.609	4.72	No	No	0	5	4
48	R:R:E175	R:R:L121	37.7655	3.98	No	No	0	5	4
49	R:R:A172	R:R:L121	28.9651	4.73	No	No	0	7	4
50	R:R:A172	R:R:T122	28.5738	3.36	No	Yes	0	7	5
51	R:R:S168	R:R:T122	26.5928	4.8	No	Yes	0	8	5
52	R:R:S168	R:R:V126	31.3537	4.85	No	No	0	8	7
53	R:R:T130	R:R:V126	30.9542	3.17	No	No	0	8	7
54	R:R:H210	R:R:Y199	21.0166	11.98	No	Yes	0	6	5
55	R:R:E175	R:R:H210	19.3861	12.31	No	No	0	5	6
56	R:R:L82	R:R:T130	30.9868	5.9	Yes	No	0	9	8
57	R:R:L89	R:R:S123	13.5695	6.01	No	No	0	7	8
58	R:R:H182	R:R:Y291	20.128	4.36	Yes	Yes	1	1	1
59	R:R:V128	R:R:W277	68.0186	4.9	No	Yes	0	8	8
60	R:R:P222	R:R:V128	66.755	3.53	No	No	0	9	8
61	R:R:I221	R:R:P222	65.4832	3.39	No	No	0	5	9
62	R:R:I221	R:R:I225	64.2033	2.94	No	No	0	5	7
63	R:R:I225	R:R:Y229	62.9153	6.04	No	No	0	7	7
64	R:R:S135	R:R:Y229	52.3173	6.36	No	No	0	9	7
65	R:R:S135	R:R:Y230	47.9477	10.17	No	Yes	4	9	8
66	R:R:Y139	R:R:Y229	11.295	9.93	No	No	0	8	7
67	R:R:D137	R:R:K140	13.863	1.38	No	No	0	8	4
68	R:R:I148	R:R:K140	11.9064	10.18	No	No	0	6	4
69	R:R:V266	R:R:Y230	39.7709	8.83	No	Yes	0	8	8
70	R:R:L262	R:R:V266	38.3361	2.98	No	No	0	8	8
71	R:R:L237	R:R:L262	28.0724	2.77	Yes	No	0	8	8
72	R:R:H206	R:R:H210	12.3181	3.58	Yes	No	0	1	6
73	R:R:L278	R:R:Y219	11.9716	9.38	No	No	0	6	8
74	R:R:L237	R:R:R259	22.1131	4.86	Yes	No	0	8	7
75	R:R:Q255	R:R:R259	17.503	5.84	No	No	0	3	7
76	R:R:L244	R:R:Q255	15.9418	2.66	No	No	0	5	3
77	R:R:I256	R:R:L244	12.8602	4.28	Yes	No	0	4	5
78	R:R:L278	R:R:P279	10.4553	3.28	No	No	0	6	9
79	R:R:A307	R:R:P279	10.5124	1.87	No	No	0	6	9
80	L:L:A22	L:L:W21	14.4255	2.59	No	Yes	0	0	0
81	L:L:A22	R:R:H300	13.0192	2.93	No	Yes	0	0	4
82	R:R:S288	R:R:Y199	28.9691	3.82	No	Yes	1	4	5
83	R:R:S211	R:R:S288	29.3645	6.52	No	No	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N19	R:R:T296	13.16	2	No	No	0	3	0	1
L:L:H20	R:R:W106	3.17	0	No	Yes	0	8	0	1
L:L:H20	R:R:S195	6.97	0	No	No	0	4	0	1
L:L:W21	R:R:Y101	6.75	2	Yes	Yes	0	4	0	1
L:L:W21	R:R:T296	8.49	2	Yes	No	0	3	0	1
L:L:W21	R:R:F301	21.05	2	Yes	Yes	0	4	0	1
L:L:V23	R:R:F193	7.87	0	No	Yes	0	1	0	1
L:L:G24	R:R:R287	4.5	0	No	No	0	4	0	1
L:L:H25	R:R:P117	10.68	0	No	No	0	5	0	1
L:L:H25	R:R:P198	19.83	0	No	No	0	4	0	1
L:L:L26	R:R:Y284	16.41	0	No	Yes	0	5	0	1
L:L:M27	R:R:C93	3.24	0	Yes	No	0	7	0	1
L:L:M27	R:R:V124	6.09	0	Yes	No	0	7	0	1
L:L:M27	R:R:N280	8.41	0	Yes	No	0	5	0	1
R:R:C93	R:R:L89	4.76	0	No	No	7	7	1	2
R:R:L89	R:R:V124	5.96	0	No	No	7	7	2	1
R:R:C93	R:R:F312	4.19	0	No	Yes	7	7	1	2
R:R:D97	R:R:Y101	9.2	2	No	Yes	6	4	2	1
R:R:D97	R:R:R308	11.91	2	No	No	6	5	2	2
R:R:R100	R:R:W106	14.99	0	No	Yes	5	8	1	1
R:R:R100	R:R:S195	5.27	0	No	No	5	4	1	1
R:R:F301	R:R:Y101	6.19	2	Yes	Yes	4	4	1	1
R:R:I305	R:R:Y101	6.04	2	No	Yes	4	4	2	1
R:R:R308	R:R:Y101	9.26	2	No	Yes	5	4	2	1
R:R:F108	R:R:W106	12.03	0	No	Yes	7	8	2	1
R:R:C196	R:R:W106	6.53	0	No	Yes	9	8	2	1
R:R:F108	R:R:I116	8.79	0	No	No	7	5	2	2
R:R:I116	R:R:P117	5.08	0	No	No	5	5	2	1
R:R:P117	R:R:Q120	3.16	0	No	No	5	6	1	2
R:R:E175	R:R:P198	4.72	0	No	No	5	4	2	1
R:R:F184	R:R:F193	11.79	1	Yes	Yes	2	1	2	1
R:R:E186	R:R:F193	3.5	1	No	Yes	3	1	2	1
R:R:E186	R:R:V294	5.7	1	No	No	3	5	2	2
R:R:F193	R:R:V294	7.87	1	Yes	No	1	5	1	2
R:R:P198	R:R:Y199	5.56	0	No	Yes	4	5	1	2
R:R:Y199	R:R:Y284	8.94	1	Yes	Yes	5	5	2	1
R:R:S288	R:R:Y199	3.82	1	No	Yes	4	5	2	2
R:R:S211	R:R:Y284	6.36	1	No	Yes	5	5	2	1
R:R:S211	R:R:S288	6.52	1	No	No	5	4	2	2
R:R:A311	R:R:N280	4.69	0	No	No	8	5	2	1
R:R:S288	R:R:Y284	8.9	1	No	Yes	4	5	2	1
R:R:D295	R:R:Y286	5.75	8	No	No	1	4	2	2
R:R:H300	R:R:Y286	4.36	8	Yes	No	4	4	1	2
R:R:D295	R:R:H300	6.3	8	No	Yes	1	4	2	1
R:R:F301	R:R:I305	6.28	2	Yes	No	4	4	1	2
R:R:F312	R:R:R308	5.34	2	Yes	No	7	5	2	2
L:L:G24	R:R:R100	3	0	No	No	0	5	0	1
L:L:A22	R:R:H300	2.93	0	No	Yes	0	4	0	1
R:R:S304	R:R:Y101	2.54	0	No	Yes	4	4	2	1
R:R:S99	R:R:W106	2.47	0	No	Yes	4	8	2	1
R:R:H300	R:R:S297	1.39	8	Yes	No	4	3	1	2
R:R:F301	R:R:M298	1.24	2	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H0Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	268
Number of Links	292
Number of Hubs	30
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	41
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	57727
Length Of Smallest Path	3
Average Path Length	18.1316
Length of Longest Path	45
Minimum Path Strength	1.445
Average Path Strength	6.80508
Maximum Path Strength	17.87
Minimum Path Correlation	0.7
Average Path Correlation	0.937303
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	50.758
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.9741
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • biological process involved in intraspecies interaction between organisms • social behavior • system process • learning or memory • nervous system process • cognition • psychomotor behavior • motor behavior • cell population proliferation • regulation of cell population proliferation • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • regulation of defense response • regulation of fear response • positive regulation of biological process • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • regulation of response to stress • response to stress • regulation of multicellular organismal process • behavioral fear response • defense response • positive regulation of behavioral fear response • multicellular organismal response to stress • fear response • positive regulation of fear response • positive regulation of behavior • regulation of response to stimulus • positive regulation of defense response • positive regulation of multicellular organismal process • positive regulation of respiratory gaseous exchange • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • regulation of localization • negative regulation of ion transmembrane transporter activity • negative regulation of potassium ion transmembrane transporter activity • negative regulation of biological process • negative regulation of transport • localization • negative regulation of voltage-gated potassium channel activity • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of potassium ion transmembrane transporter activity • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • establishment of localization • regulation of cation channel activity • inorganic cation transmembrane transport • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • potassium ion transport • regulation of potassium ion transport • negative regulation of cation channel activity • transport • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • regulation of transmembrane transporter activity • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • negative regulation of transmembrane transport • metal ion transport • regulation of transporter activity • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • regulation of metal ion transport • negative regulation of potassium ion transport • regulation of monoatomic ion transmembrane transporter activity • regulation of transport • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of voltage-gated sodium channel activity • sodium ion transmembrane transport • regulation of sodium ion transport • regulation of sodium ion transmembrane transport • regulation of voltage-gated sodium channel activity • negative regulation of sodium ion transmembrane transport • negative regulation of sodium ion transmembrane transporter activity • regulation of sodium ion transmembrane transporter activity • negative regulation of sodium ion transport • sodium ion transport • neuropeptide signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • regulation of signaling • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell communication • regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • establishment of organelle localization • regulated exocytosis • cellular localization • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • ossification • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • cellular response to sodium phosphate • cellular response to chemical stimulus • response to chemical • response to sodium phosphate • cellular response to salt • response to salt • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of smooth muscle cell apoptotic process • smooth muscle cell apoptotic process • regulation of apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • regulation of smooth muscle cell apoptotic process • positive regulation of apoptotic process • positive regulation of muscle cell apoptotic process • vascular associated smooth muscle cell apoptotic process • positive regulation of vascular associated smooth muscle cell apoptotic process • regulation of vascular associated smooth muscle cell apoptotic process • apoptotic process • programmed cell death • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • positive regulation of peptide secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • regulation of peptide transport • cell-cell signaling • regulation of secretion • peptide transport • positive regulation of transport • peptide hormone secretion • hormone transport • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • establishment of protein localization • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • protein localization to extracellular region • regulation of establishment of protein localization • regulation of protein transport • protein transport • regulation of insulin secretion • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • intracellular transport • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • nucleus • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30550
Sequence	>8H0Q_nogp_Chain_R V I P A V Y G V I I L I G L I G N I T L I K I F C T V K S M R N V P N L F I S S L A L G D L L L L I T C A P V D A S R Y L A D R W L F G R I G C K L I P F I Q L T S V G V S V F T Q T A L S A D R Y K A I V R P M D I Q A S H A L M K I C L K A A F I W I I S M L L A I P E A V F S D L H P F H E Q T F I S C A P Y P H S N E L H P K I H S M A S F L V F Y V I P L S I I S V Y Y Y F I A K N L I Q S A Y N L P V E G N I H V K K Q I E S R K R L A K T V L V F V G L F A F C W L P N H V I Y L Y R S Y H Y S E V D T S M L H F V T S I C A R L L A F T N S C V N P F A L Y L L S K S F R K Q F N T Q L L C C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H0Q	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.3	2023-08-09	10.1038/s41422-022-00743-6
	8H0Q (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-		3.3	2023-08-09	10.1038/s41422-022-00743-6
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	10.1073/pnas.2216230120
	7W40	A	Peptide	Bombesin	BB₂	Homo sapiens	Bombesin	-	chim(NtGi1L-Gq)/β1/γ2	3	2023-02-22	10.1073/pnas.2216230120
	7W40 (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Bombesin	-		3	2023-02-22	10.1073/pnas.2216230120
	7W3Z	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-	chim(NtGi1L-Gq)/β1/γ2	3	2023-02-22	10.1073/pnas.2216230120
	7W3Z (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-		3	2023-02-22	10.1073/pnas.2216230120

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