psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P37	R:R:Y41	11.13	No	No	0	6	3
2	R:R:I43	R:R:P44	3.39	Yes	No	0	6	6
3	R:R:I43	R:R:Y47	4.84	Yes	Yes	0	6	7
4	R:R:I43	R:R:Y101	4.84	Yes	Yes	0	6	4
5	R:R:L102	R:R:P44	8.21	No	No	0	4	6
6	R:R:D97	R:R:Y47	6.9	Yes	Yes	0	6	7
7	R:R:L309	R:R:Y47	11.72	No	Yes	0	5	7
8	R:R:F312	R:R:Y47	4.13	Yes	Yes	0	7	7
9	R:R:G48	R:R:I51	3.53	No	No	0	4	7
10	R:R:A94	R:R:I51	3.25	No	No	0	7	7
11	R:R:I56	R:R:L52	4.28	No	No	0	5	5
12	R:R:I91	R:R:L55	4.28	No	No	0	5	6
13	R:R:G57	R:R:I56	3.53	No	No	0	8	5
14	R:R:F320	R:R:G57	4.52	No	No	0	5	8
15	R:R:A83	R:R:N58	3.13	No	No	0	9	9
16	R:R:D86	R:R:N58	6.73	Yes	No	0	9	9
17	R:R:N58	R:R:P319	4.89	No	No	0	9	9
18	R:R:F333	R:R:T60	14.27	Yes	No	2	7	7
19	R:R:L337	R:R:T60	7.37	No	No	2	7	7
20	R:R:I79	R:R:L61	4.28	No	No	0	8	9
21	R:R:A83	R:R:L61	4.73	No	No	0	9	9
22	R:R:L61	R:R:P319	3.28	No	No	0	9	9
23	R:R:A83	R:R:I62	3.25	No	No	0	9	7
24	R:R:K63	R:R:T67	3	No	Yes	4	4	5
25	R:R:K63	R:R:Q336	10.85	No	No	4	4	5
26	R:R:F329	R:R:I64	3.77	No	No	0	9	7
27	R:R:I64	R:R:Q336	5.49	No	No	0	7	5
28	R:R:F65	R:R:R72	14.97	No	No	0	7	7
29	R:R:F65	R:R:S80	7.93	No	No	0	7	5
30	R:R:Q336	R:R:T67	14.17	No	Yes	4	5	5
31	R:R:S70	R:R:V68	3.23	No	Yes	0	6	6
32	R:R:M71	R:R:V68	9.13	No	Yes	0	7	6
33	R:R:M71	R:R:N76	4.21	No	No	0	7	8
34	R:R:N73	R:R:P75	11.4	No	No	0	8	8
35	R:R:N73	R:R:N76	8.17	No	No	0	8	8
36	R:R:P75	R:R:V74	3.53	No	No	0	8	7
37	R:R:D137	R:R:V74	4.38	No	No	0	8	7
38	R:R:C158	R:R:L77	3.17	No	No	0	1	6
39	R:R:A133	R:R:F78	5.55	No	Yes	0	7	7
40	R:R:D137	R:R:F78	4.78	No	Yes	0	8	7
41	R:R:F78	R:R:K160	3.72	Yes	No	0	7	6
42	R:R:S81	R:R:T130	6.4	No	No	0	9	8
43	R:R:A161	R:R:S81	3.42	No	No	0	7	9
44	R:R:D86	R:R:L82	8.14	Yes	Yes	1	9	9
45	R:R:L82	R:R:S127	3	Yes	No	1	9	9
46	R:R:L131	R:R:L82	6.92	No	Yes	1	9	9
47	R:R:L82	R:R:N318	6.87	Yes	Yes	1	9	9
48	R:R:L84	R:R:W165	3.42	No	No	0	7	9
49	R:R:D86	R:R:S127	5.89	Yes	No	1	9	9
50	R:R:D86	R:R:S315	10.31	Yes	No	0	9	8
51	R:R:D86	R:R:N318	6.73	Yes	Yes	1	9	9
52	R:R:L88	R:R:S123	6.01	No	No	0	7	8
53	R:R:C93	R:R:L89	4.76	Yes	Yes	1	7	7
54	R:R:L89	R:R:S123	3	Yes	No	0	7	8
55	R:R:L89	R:R:S315	4.5	Yes	No	0	7	8
56	L:L:M27	R:R:L89	7.07	Yes	Yes	1	0	7
57	R:R:L90	R:R:S315	7.51	No	No	0	6	8
58	R:R:I119	R:R:T92	4.56	No	No	0	5	5
59	R:R:C93	R:R:Q120	10.68	Yes	No	1	7	6
60	R:R:C93	R:R:F312	4.19	Yes	Yes	1	7	7
61	L:L:M27	R:R:C93	4.86	Yes	Yes	1	0	7
62	R:R:A94	R:R:F312	4.16	No	Yes	0	7	7
63	R:R:R100	R:R:V96	3.92	Yes	Yes	0	5	6
64	R:R:F108	R:R:V96	7.87	Yes	Yes	1	7	6
65	R:R:I116	R:R:V96	4.61	Yes	Yes	1	5	6
66	R:R:Q120	R:R:V96	4.3	No	Yes	1	6	6
67	R:R:D97	R:R:Y101	8.05	Yes	Yes	1	6	4
68	R:R:D97	R:R:R308	4.76	Yes	Yes	1	6	5
69	L:L:?28	R:R:D97	6.72	Yes	Yes	1	0	6
70	R:R:R100	R:R:W106	9	Yes	Yes	0	5	8
71	L:L:H25	R:R:R100	7.9	Yes	Yes	0	0	5
72	L:L:?28	R:R:R100	3.01	Yes	Yes	0	0	5
73	R:R:F301	R:R:Y101	6.19	Yes	Yes	1	4	4
74	R:R:S304	R:R:Y101	3.82	No	Yes	0	4	4
75	L:L:W21	R:R:Y101	14.47	Yes	Yes	1	0	4
76	R:R:D104	R:R:R105	4.76	No	No	0	4	4
77	L:L:R17	R:R:D104	5.96	No	No	0	0	4
78	R:R:L107	R:R:R105	3.64	No	No	0	3	4
79	R:R:F108	R:R:W106	15.03	Yes	Yes	1	7	8
80	R:R:C113	R:R:W106	5.22	No	Yes	1	9	8
81	R:R:C196	R:R:W106	18.28	No	Yes	1	9	8
82	L:L:H20	R:R:W106	3.17	No	Yes	1	0	8
83	R:R:F108	R:R:I116	5.02	Yes	Yes	1	7	5
84	R:R:K114	R:R:R110	4.95	No	No	0	7	4
85	R:R:D180	R:R:R110	13.1	No	No	0	4	4
86	R:R:C113	R:R:L181	3.17	No	No	0	9	4
87	R:R:C113	R:R:C196	7.28	No	No	1	9	9
88	R:R:I116	R:R:P117	3.39	Yes	Yes	1	5	5
89	R:R:I116	R:R:Q120	4.12	Yes	No	1	5	6
90	R:R:E175	R:R:P117	4.72	Yes	Yes	1	5	5
91	R:R:P117	R:R:S179	7.13	Yes	No	1	5	5
92	L:L:H25	R:R:P117	10.68	Yes	Yes	1	0	5
93	R:R:F118	R:R:M169	3.73	Yes	No	0	6	4
94	R:R:A172	R:R:F118	6.93	No	Yes	0	7	6
95	R:R:F118	R:R:I173	5.02	Yes	Yes	0	6	4
96	R:R:F218	R:R:L121	8.53	Yes	No	0	6	4
97	R:R:M169	R:R:T122	10.54	No	No	0	4	5
98	R:R:A172	R:R:T122	3.36	No	No	0	7	5
99	R:R:G125	R:R:V124	3.68	Yes	No	1	6	7
100	R:R:F218	R:R:V124	5.24	Yes	No	1	6	7
101	R:R:F129	R:R:G125	3.01	Yes	Yes	1	5	6
102	R:R:G125	R:R:S168	3.71	Yes	No	0	6	8
103	R:R:F218	R:R:G125	3.01	Yes	Yes	1	6	6
104	R:R:V126	R:R:W165	17.16	No	No	0	7	9
105	R:R:S168	R:R:V126	4.85	No	No	0	8	7
106	R:R:F129	R:R:V128	7.87	Yes	No	0	5	8
107	R:R:P222	R:R:V128	5.3	No	No	0	9	8
108	R:R:F129	R:R:I164	6.28	Yes	No	0	5	7
109	R:R:F129	R:R:F218	3.22	Yes	Yes	1	5	6
110	R:R:I164	R:R:T130	3.04	No	No	0	7	8
111	R:R:L131	R:R:N318	9.61	No	Yes	1	9	9
112	R:R:I225	R:R:T132	4.56	No	No	0	7	7
113	R:R:I226	R:R:T132	4.56	No	No	0	8	7
114	R:R:L134	R:R:R138	3.64	No	Yes	0	9	9
115	R:R:I226	R:R:S135	7.74	No	No	0	8	9
116	R:R:S135	R:R:Y230	12.72	No	Yes	0	9	8
117	R:R:A136	R:R:Y229	5.34	No	No	0	7	7
118	R:R:R138	R:R:Y230	8.23	Yes	Yes	0	9	8
119	R:R:L322	R:R:R138	3.64	No	Yes	0	9	9
120	R:R:V143	R:R:Y139	12.62	No	Yes	0	7	8
121	R:R:Y139	R:R:Y229	12.91	Yes	No	0	8	7
122	R:R:F232	R:R:Y139	4.13	Yes	Yes	0	3	8
123	R:R:I233	R:R:Y139	3.63	Yes	Yes	0	8	8
124	R:R:N236	R:R:V143	8.87	No	No	0	5	7
125	R:R:D147	R:R:M146	8.32	No	No	0	5	5
126	R:R:H152	R:R:M155	3.94	No	No	0	7	3
127	R:R:F163	R:R:I167	6.28	No	No	0	3	4
128	R:R:F218	R:R:L171	4.87	Yes	No	0	6	6
129	R:R:I173	R:R:P174	3.39	Yes	No	0	4	7
130	R:R:E175	R:R:P198	6.29	Yes	No	1	5	4
131	R:R:E175	R:R:H210	7.39	Yes	No	1	5	6
132	L:L:H25	R:R:E175	7.39	Yes	Yes	1	0	5
133	R:R:F178	R:R:H206	14.71	No	Yes	0	5	1
134	L:L:H25	R:R:S179	5.58	Yes	No	1	0	5
135	R:R:D180	R:R:H182	5.04	No	Yes	0	4	1
136	R:R:A197	R:R:H182	4.39	No	Yes	0	1	1
137	R:R:H182	R:R:P200	6.1	Yes	No	0	1	5
138	R:R:H182	R:R:Y291	3.27	Yes	Yes	0	1	1
139	R:R:F184	R:R:F193	6.43	Yes	Yes	1	2	1
140	R:R:F184	R:R:S195	3.96	Yes	No	1	2	4
141	R:R:F184	R:R:H201	12.44	Yes	No	1	2	3
142	R:R:F184	R:R:Y291	8.25	Yes	Yes	1	2	1
143	R:R:F184	R:R:V294	3.93	Yes	No	1	2	5
144	L:L:V23	R:R:F184	19.66	No	Yes	1	0	2
145	R:R:H185	R:R:N190	3.83	No	No	0	2	3
146	R:R:H185	R:R:T192	4.11	No	No	0	2	4
147	R:R:E186	R:R:T189	12.7	No	No	0	3	1
148	R:R:E186	R:R:F193	9.33	No	Yes	0	3	1
149	L:L:N19	R:R:E186	13.15	No	No	0	0	3
150	R:R:E187	R:R:E293	13.95	No	No	0	4	5
151	R:R:S188	R:R:T296	3.2	No	No	0	3	3
152	L:L:R17	R:R:Q191	8.18	No	No	0	0	2
153	R:R:F193	R:R:S195	3.96	Yes	No	1	1	4
154	R:R:F193	R:R:V294	3.93	Yes	No	1	1	5
155	L:L:G18	R:R:F193	6.02	No	Yes	0	0	1
156	L:L:H20	R:R:F193	4.53	No	Yes	1	0	1
157	L:L:H20	R:R:S195	15.34	No	No	1	0	4
158	R:R:P198	R:R:Y199	11.13	No	Yes	1	4	5
159	L:L:H25	R:R:P198	12.2	Yes	No	1	0	4
160	R:R:H206	R:R:Y199	6.53	Yes	Yes	1	1	5
161	R:R:P207	R:R:Y199	15.3	No	Yes	1	3	5
162	R:R:S288	R:R:Y199	6.36	No	Yes	1	4	5
163	R:R:Y199	R:R:Y291	21.84	Yes	Yes	1	5	1
164	R:R:P200	R:R:S202	3.56	No	No	0	5	3
165	R:R:H201	R:R:Y291	21.78	No	Yes	1	3	1
166	R:R:H206	R:R:N203	6.38	Yes	No	0	1	2
167	R:R:I209	R:R:L205	4.28	No	No	0	4	1
168	R:R:H206	R:R:P207	4.58	Yes	No	1	1	3
169	R:R:K208	R:R:Y289	13.14	No	No	0	3	5
170	R:R:H210	R:R:S214	6.97	No	No	1	6	6
171	R:R:H210	R:R:Y284	4.36	No	Yes	1	6	5
172	R:R:S211	R:R:Y284	5.09	No	Yes	1	5	5
173	R:R:L285	R:R:S211	3	No	No	0	5	5
174	R:R:S211	R:R:S288	6.52	No	No	1	5	4
175	R:R:M212	R:R:Y289	3.59	No	No	0	4	5
176	R:R:F218	R:R:S214	3.96	Yes	No	1	6	6
177	R:R:S214	R:R:Y284	3.82	No	Yes	1	6	5
178	R:R:F215	R:R:Y219	8.25	No	Yes	1	6	8
179	R:R:F215	R:R:V220	3.93	No	No	0	6	5
180	R:R:F215	R:R:H281	7.92	No	No	1	6	7
181	R:R:L216	R:R:V220	5.96	No	No	0	4	5
182	R:R:F218	R:R:V217	9.18	Yes	No	0	6	5
183	R:R:L223	R:R:Y219	4.69	Yes	Yes	0	6	8
184	R:R:L278	R:R:Y219	7.03	No	Yes	0	6	8
185	R:R:H281	R:R:Y219	5.44	No	Yes	1	7	8
186	R:R:I221	R:R:P222	3.39	No	No	0	5	9
187	R:R:L223	R:R:S227	3	Yes	No	0	6	5
188	R:R:F273	R:R:L223	6.09	No	Yes	0	9	6
189	R:R:A274	R:R:L223	3.15	No	Yes	0	6	6
190	R:R:I226	R:R:V270	3.07	No	No	0	8	7
191	R:R:S227	R:R:V270	3.23	No	No	0	5	7
192	R:R:I233	R:R:Y230	3.63	Yes	Yes	3	8	8
193	R:R:V266	R:R:Y230	7.57	No	Yes	3	8	8
194	R:R:V270	R:R:Y230	3.79	No	Yes	0	7	8
195	R:R:F232	R:R:Y231	5.16	Yes	No	0	3	3
196	R:R:I233	R:R:V266	3.07	Yes	No	3	8	8
197	R:R:A234	R:R:L267	4.73	No	No	0	6	5
198	R:R:N236	R:R:Q239	3.96	No	No	0	5	4
199	R:R:L237	R:R:L262	4.15	No	No	0	8	8
200	R:R:A263	R:R:I238	3.25	No	No	0	6	4
201	R:R:Q239	R:R:Y242	5.64	No	No	5	4	3
202	R:R:N243	R:R:Q239	3.96	No	No	5	2	4
203	R:R:R259	R:R:S240	3.95	No	No	0	7	6
204	R:R:N243	R:R:Y242	8.14	No	No	5	2	3
205	R:R:L244	R:R:P245	4.93	No	No	0	5	3
206	R:R:L244	R:R:V252	4.47	No	Yes	0	5	3
207	R:R:L244	R:R:R259	6.07	No	No	0	5	7
208	R:R:V246	R:R:V252	4.81	No	Yes	0	3	3
209	R:R:G248	R:R:H251	3.18	No	No	0	5	3
210	R:R:H251	R:R:I250	10.61	No	No	0	3	2
211	R:R:I256	R:R:V252	3.07	No	Yes	0	4	3
212	R:R:K254	R:R:Q255	5.42	No	No	0	4	3
213	R:R:I256	R:R:K260	4.36	No	No	0	4	5
214	R:R:L325	R:R:R261	4.86	No	No	0	7	8
215	R:R:L325	R:R:T265	10.32	No	No	0	7	8
216	R:R:A321	R:R:F269	4.16	No	No	0	8	7
217	R:R:L272	R:R:V317	4.47	No	No	0	7	6
218	R:R:F273	R:R:W277	13.03	No	Yes	1	9	8
219	R:R:F273	R:R:N314	6.04	No	Yes	1	9	9
220	R:R:F275	R:R:L310	6.09	No	No	0	6	8
221	R:R:C276	R:R:L310	4.76	No	No	0	8	8
222	R:R:H281	R:R:W277	4.23	No	Yes	1	7	8
223	R:R:N314	R:R:W277	9.04	Yes	Yes	1	9	8
224	L:L:M27	R:R:W277	5.82	Yes	Yes	1	0	8
225	R:R:L278	R:R:P279	3.28	No	No	0	6	9
226	R:R:A307	R:R:P279	3.74	No	No	0	6	9
227	R:R:L310	R:R:P279	4.93	No	No	0	8	9
228	R:R:N280	R:R:R308	9.64	No	Yes	0	5	5
229	R:R:A311	R:R:N280	6.25	No	No	0	8	5
230	L:L:M27	R:R:N280	7.01	Yes	No	0	0	5
231	R:R:I283	R:R:R287	6.26	No	Yes	1	5	4
232	R:R:I283	R:R:T303	3.04	No	No	0	5	4
233	R:R:I283	R:R:R308	5.01	No	Yes	1	5	5
234	R:R:S288	R:R:Y284	6.36	No	Yes	1	4	5
235	L:L:L26	R:R:Y284	8.21	No	Yes	0	0	5
236	R:R:L285	R:R:Y289	3.52	No	No	0	5	5
237	R:R:H290	R:R:Y286	6.53	No	No	0	2	4
238	R:R:D295	R:R:Y286	4.6	No	No	0	1	4
239	R:R:H300	R:R:Y286	3.27	Yes	No	0	4	4
240	R:R:H300	R:R:R287	7.9	Yes	Yes	0	4	4
241	R:R:R287	R:R:R308	7.46	Yes	Yes	1	4	5
242	L:L:V23	R:R:V294	4.81	No	No	1	0	5
243	R:R:D295	R:R:S297	5.89	No	No	0	1	3
244	L:L:N19	R:R:T296	5.85	No	No	0	0	3
245	R:R:H300	R:R:S304	6.97	Yes	No	0	4	4
246	L:L:W21	R:R:H300	5.29	Yes	Yes	0	0	4
247	R:R:F301	R:R:I305	7.54	Yes	No	0	4	4
248	L:L:W21	R:R:F301	15.03	Yes	Yes	1	0	4
249	L:L:?28	R:R:R308	15.03	Yes	Yes	1	0	5
250	L:L:M27	R:R:F312	4.98	Yes	Yes	1	0	7
251	R:R:N314	R:R:N318	12.26	Yes	Yes	1	9	9
252	R:R:N318	R:R:P319	3.26	Yes	No	0	9	9
253	R:R:L324	R:R:Y323	3.52	No	Yes	0	6	7
254	R:R:R330	R:R:Y323	13.38	No	Yes	2	8	7
255	R:R:F333	R:R:Y323	8.25	Yes	Yes	2	7	7
256	R:R:N334	R:R:Y323	5.81	No	Yes	2	4	7
257	R:R:S326	R:R:S328	4.89	No	No	0	8	6
258	R:R:F329	R:R:F333	4.29	No	Yes	0	9	7
259	R:R:N334	R:R:R330	3.62	No	No	2	4	8
260	R:R:F333	R:R:L337	4.87	Yes	No	2	7	7
261	L:L:N19	L:L:W21	7.91	No	Yes	0	0	0
262	L:L:A22	L:L:W21	3.89	No	Yes	0	0	0
263	L:L:L26	L:L:M27	7.07	No	Yes	0	0	0
264	L:L:?28	L:L:M27	7	Yes	Yes	1	0	0
265	R:R:L272	R:R:V268	2.98	No	No	0	7	6
266	R:R:L278	R:R:V282	2.98	No	No	0	6	7
267	R:R:N314	R:R:V317	2.96	Yes	No	0	9	6
268	R:R:L299	R:R:T303	2.95	No	No	0	2	4
269	R:R:I142	R:R:I233	2.94	No	Yes	3	8	8
270	R:R:G38	R:R:Y41	2.9	No	No	0	3	3
271	R:R:Q332	R:R:V68	2.87	No	Yes	0	6	6
272	R:R:Q255	R:R:V252	2.87	No	Yes	0	3	3
273	R:R:I51	R:R:L55	2.85	No	No	0	7	6
274	R:R:I59	R:R:L87	2.85	No	No	0	4	8
275	R:R:I62	R:R:L87	2.85	No	No	0	7	8
276	R:R:I142	R:R:L237	2.85	No	No	3	8	8
277	R:R:I233	R:R:L237	2.85	Yes	No	3	8	8
278	R:R:L159	R:R:M155	2.83	No	No	0	3	3
279	R:R:G109	R:R:W106	2.81	No	Yes	0	8	8
280	R:R:A157	R:R:F78	2.77	No	Yes	0	7	7
281	R:R:A176	R:R:F118	2.77	No	Yes	0	5	6
282	R:R:A241	R:R:R259	2.77	No	No	0	3	7
283	R:R:F329	R:R:S326	2.64	No	No	0	9	8
284	R:R:F232	R:R:V228	2.62	Yes	No	0	3	4
285	R:R:F269	R:R:T265	2.59	No	No	0	7	8
286	R:R:F320	R:R:I53	2.51	No	No	0	5	6
287	R:R:F78	R:R:L134	2.44	Yes	No	0	7	9
288	R:R:T122	R:R:W165	2.43	No	No	0	5	9
289	R:R:F65	R:R:N76	2.42	No	No	0	7	8
290	R:R:I238	R:R:Y242	2.42	No	No	0	4	3
291	R:R:F193	R:R:Q191	2.34	Yes	No	0	1	2
292	R:R:F269	R:R:R138	2.14	No	Yes	0	7	9
293	R:R:C316	R:R:G54	1.96	No	No	0	7	8
294	R:R:A94	R:R:P95	1.87	No	No	0	7	9
295	R:R:G85	R:R:V126	1.84	No	No	0	8	7
296	R:R:G248	R:R:V246	1.84	No	No	0	5	3
297	R:R:A234	R:R:A263	1.79	No	No	0	6	6
298	R:R:G54	R:R:I53	1.76	No	No	0	8	6
299	R:R:G54	R:R:L90	1.71	No	No	0	8	6
300	R:R:G112	R:R:L115	1.71	No	No	0	6	5
301	R:R:C306	R:R:V302	1.71	No	No	0	4	1
302	R:R:C316	R:R:V317	1.71	No	No	0	7	6
303	R:R:A153	R:R:V74	1.7	No	No	0	7	7
304	R:R:C66	R:R:T67	1.69	No	Yes	0	3	5
305	R:R:C93	R:R:T92	1.69	Yes	No	0	7	5
306	R:R:I194	R:R:P183	1.69	No	No	0	4	2
307	R:R:C316	R:R:T313	1.69	No	No	0	7	5
308	R:R:E247	R:R:G248	1.64	No	No	0	4	5
309	R:R:S99	R:R:V96	1.62	No	Yes	0	4	6
310	R:R:S224	R:R:V220	1.62	No	No	0	3	5
311	R:R:A150	R:R:K156	1.61	No	No	0	5	4
312	R:R:V42	R:R:V46	1.6	No	No	0	5	6
313	R:R:T67	R:R:V68	1.59	Yes	Yes	0	5	6
314	R:R:C158	R:R:L154	1.59	No	No	0	1	2
315	R:R:A157	R:R:L77	1.58	No	No	0	7	6
316	R:R:A161	R:R:L77	1.58	No	No	0	7	6
317	R:R:I50	R:R:V46	1.54	No	No	0	7	6
318	R:R:I53	R:R:V49	1.54	No	No	0	6	4
319	R:R:I173	R:R:V177	1.54	Yes	No	0	4	4
320	R:R:H182	R:R:P183	1.53	Yes	No	0	1	2
321	R:R:M298	R:R:V302	1.52	No	No	0	3	1
322	R:R:F108	R:R:G112	1.51	Yes	No	0	7	6
323	L:L:G24	R:R:R100	1.5	No	Yes	0	0	5
324	L:L:G24	R:R:R287	1.5	No	Yes	0	0	4
325	R:R:K331	R:R:T335	1.5	No	No	0	4	4
326	R:R:L309	R:R:V46	1.49	No	No	0	5	6
327	R:R:P145	R:R:R144	1.44	No	No	0	8	6
328	R:R:E293	R:R:S292	1.44	No	No	0	5	1
329	R:R:I43	R:R:L40	1.43	Yes	No	0	6	4
330	R:R:I167	R:R:L171	1.43	No	No	0	4	6
331	R:R:I173	R:R:L170	1.43	Yes	No	0	4	4
332	R:R:H152	R:R:S151	1.39	No	No	0	7	5
333	R:R:L205	R:R:N203	1.37	No	No	0	1	2
334	R:R:R144	R:R:V143	1.31	No	No	0	6	7
335	R:R:F301	R:R:I39	1.26	Yes	No	0	4	4
336	R:R:K140	R:R:R144	1.24	No	No	0	4	6
337	R:R:F232	R:R:K235	1.24	Yes	No	0	3	3
338	R:R:F301	R:R:M298	1.24	Yes	No	0	4	3
339	R:R:E204	R:R:Y291	1.12	No	Yes	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I43	3.625	4	0	6
2	R:R:Y47	6.8975	4	0	7
3	R:R:T67	5.1125	4	4	5
4	R:R:V68	4.205	4	0	6
5	R:R:F78	3.852	5	0	7
6	R:R:L82	6.2325	4	1	9
7	R:R:D86	7.56	5	1	9
8	R:R:L89	4.8325	4	1	7
9	R:R:C93	5.236	5	1	7
10	R:R:V96	4.464	5	1	6
11	R:R:D97	6.6075	4	1	6
12	R:R:R100	5.066	5	0	5
13	R:R:Y101	7.474	5	1	4
14	R:R:W106	8.91833	6	1	8
15	R:R:F108	7.3575	4	1	7
16	R:R:I116	4.285	4	1	5
17	R:R:P117	6.48	4	1	5
18	R:R:F118	4.6125	4	0	6
19	R:R:G125	3.3525	4	1	6
20	R:R:F129	5.095	4	1	5
21	R:R:R138	4.4125	4	0	9
22	R:R:Y139	8.3225	4	0	8
23	R:R:I173	2.845	4	0	4
24	R:R:E175	6.4475	4	1	5
25	R:R:H182	4.066	5	0	1
26	R:R:F184	9.11167	6	1	2
27	R:R:F193	5.22	7	1	1
28	R:R:Y199	12.232	5	1	5
29	R:R:H206	8.05	4	1	1
30	R:R:F218	5.43	7	1	6
31	R:R:Y219	6.3525	4	1	8
32	R:R:L223	4.2325	4	0	6
33	R:R:Y230	7.188	5	3	8
34	R:R:F232	3.2875	4	0	3
35	R:R:I233	3.224	5	3	8
36	R:R:V252	3.805	4	0	3
37	R:R:W277	8.03	4	1	8
38	R:R:Y284	5.568	5	1	5
39	R:R:R287	5.78	4	1	4
40	R:R:Y291	11.252	5	1	1
41	R:R:H300	5.8575	4	0	4
42	R:R:F301	6.252	5	1	4
43	R:R:R308	8.38	5	1	5
44	R:R:F312	4.365	4	1	7
45	R:R:N314	7.575	4	1	9
46	R:R:N318	7.746	5	1	9
47	R:R:Y323	7.74	4	2	7
48	R:R:F333	7.92	4	2	7
49	L:L:W21	9.318	5	1	0
50	L:L:H25	8.75	5	1	0
51	L:L:M27	6.25857	7	1	0
52	L:L:?28	7.94	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D97	R:R:Y101	23.157	8.05	Yes	Yes	1	6	4
2	R:R:L309	R:R:Y47	10.2142	11.72	No	Yes	0	5	7
3	R:R:F312	R:R:Y47	17.3127	4.13	Yes	Yes	0	7	7
4	R:R:A94	R:R:F312	13.9636	4.16	No	Yes	0	7	7
5	R:R:L89	R:R:S315	23.9042	4.5	Yes	No	0	7	8
6	R:R:L90	R:R:S315	12.5158	7.51	No	No	0	6	8
7	R:R:G54	R:R:L90	10.6011	1.71	No	No	0	8	6
8	R:R:G54	R:R:I53	12.8027	1.76	No	No	0	8	6
9	L:L:M27	R:R:F312	22.5032	4.98	Yes	Yes	1	0	7
10	L:L:M27	R:R:L89	23.4238	7.07	Yes	Yes	1	0	7
11	R:R:A83	R:R:N58	11.5885	3.13	No	No	0	9	9
12	R:R:D86	R:R:N58	11.2683	6.73	Yes	No	0	9	9
13	R:R:D86	R:R:S315	13.4899	10.31	Yes	No	0	9	8
14	L:L:M27	R:R:W277	100	5.82	Yes	Yes	1	0	8
15	R:R:N314	R:R:W277	17.2927	9.04	Yes	Yes	1	9	8
16	R:R:N314	R:R:N318	24.4179	12.26	Yes	Yes	1	9	9
17	R:R:N318	R:R:P319	12.9028	3.26	Yes	No	0	9	9
18	R:R:F329	R:R:F333	14.1904	4.29	No	Yes	0	9	7
19	R:R:F329	R:R:I64	20.0747	3.77	No	No	0	9	7
20	R:R:I64	R:R:Q336	22.0095	5.49	No	No	0	7	5
21	R:R:Q336	R:R:T67	23.704	14.17	No	Yes	4	5	5
22	R:R:T67	R:R:V68	29.4683	1.59	Yes	Yes	0	5	6
23	R:R:M71	R:R:V68	34.8989	9.13	No	Yes	0	7	6
24	R:R:M71	R:R:N76	36.7269	4.21	No	No	0	7	8
25	R:R:N73	R:R:N76	43.9055	8.17	No	No	0	8	8
26	R:R:N73	R:R:P75	45.6668	11.4	No	No	0	8	8
27	R:R:P75	R:R:V74	47.4148	3.53	No	No	0	8	7
28	R:R:D137	R:R:V74	50.7572	4.38	No	No	0	8	7
29	R:R:D137	R:R:F78	52.4718	4.78	No	Yes	0	8	7
30	R:R:F78	R:R:L134	51.9581	2.44	Yes	No	0	7	9
31	R:R:L134	R:R:R138	53.0589	3.64	No	Yes	0	9	9
32	R:R:R138	R:R:Y230	60.4176	8.23	Yes	Yes	0	9	8
33	R:R:V270	R:R:Y230	87.1172	3.79	No	Yes	0	7	8
34	R:R:S227	R:R:V270	92.9348	3.23	No	No	0	5	7
35	R:R:L223	R:R:S227	93.9756	3	Yes	No	0	6	5
36	R:R:F273	R:R:L223	91.2269	6.09	No	Yes	0	9	6
37	R:R:F273	R:R:W277	69.8846	13.03	No	Yes	1	9	8
38	R:R:A83	R:R:I62	10.6411	3.25	No	No	0	9	7
39	R:R:A161	R:R:L77	26.8864	1.58	No	No	0	7	6
40	R:R:A161	R:R:S81	27.5335	3.42	No	No	0	7	9
41	R:R:S81	R:R:T130	28.3741	6.4	No	No	0	9	8
42	R:R:I164	R:R:T130	29.2815	3.04	No	No	0	7	8
43	R:R:F129	R:R:I164	30.1888	6.28	Yes	No	0	5	7
44	R:R:F129	R:R:F218	22.8501	3.22	Yes	Yes	1	5	6
45	R:R:F218	R:R:S214	60.2308	3.96	Yes	No	1	6	6
46	R:R:S214	R:R:Y284	51.5912	3.82	No	Yes	1	6	5
47	L:L:L26	R:R:Y284	58.2894	8.21	No	Yes	0	0	5
48	L:L:L26	L:L:M27	59.15	7.07	No	Yes	0	0	0
49	R:R:F218	R:R:G125	30.6758	3.01	Yes	Yes	1	6	6
50	R:R:G125	R:R:S168	39.7558	3.71	Yes	No	0	6	8
51	R:R:S168	R:R:V126	37.8945	4.85	No	No	0	8	7
52	R:R:V126	R:R:W165	34.1317	17.16	No	No	0	7	9
53	R:R:C93	R:R:Q120	13.7101	10.68	Yes	No	1	7	6
54	L:L:?28	R:R:D97	23.624	6.72	Yes	Yes	1	0	6
55	L:L:?28	R:R:R100	37.5609	3.01	Yes	Yes	0	0	5
56	R:R:R100	R:R:W106	29.535	9	Yes	Yes	0	5	8
57	L:L:H25	R:R:R100	15.2045	7.9	Yes	Yes	0	0	5
58	L:L:W21	R:R:Y101	12.7827	14.47	Yes	Yes	1	0	4
59	R:R:F193	R:R:Q191	10.1341	2.34	Yes	No	0	1	2
60	R:R:E186	R:R:F193	10.3943	9.33	No	Yes	0	3	1
61	L:L:N19	L:L:W21	12.5692	7.91	No	Yes	0	0	0
62	L:L:H20	R:R:W106	21.7226	3.17	No	Yes	1	0	8
63	L:L:H20	R:R:F193	16.5188	4.53	No	Yes	1	0	1
64	R:R:F184	R:R:F193	11.3683	6.43	Yes	Yes	1	2	1
65	R:R:F184	R:R:Y291	12.9495	8.25	Yes	Yes	1	2	1
66	R:R:H182	R:R:Y291	16.9791	3.27	Yes	Yes	0	1	1
67	R:R:F118	R:R:M169	12.209	3.73	Yes	No	0	6	4
68	R:R:M169	R:R:T122	14.1971	10.54	No	No	0	4	5
69	R:R:T122	R:R:W165	30.3156	2.43	No	No	0	5	9
70	R:R:A172	R:R:F118	12.209	6.93	No	Yes	0	7	6
71	R:R:A172	R:R:T122	14.1971	3.36	No	No	0	7	5
72	R:R:F118	R:R:I173	16.3253	5.02	Yes	Yes	0	6	4
73	R:R:I233	R:R:Y139	39.7758	3.63	Yes	Yes	0	8	8
74	R:R:I233	R:R:Y230	47.1879	3.63	Yes	Yes	3	8	8
75	R:R:V143	R:R:Y139	25.6255	12.62	No	Yes	0	7	8
76	R:R:N236	R:R:V143	17.2393	8.87	No	No	0	5	7
77	R:R:H206	R:R:Y199	10.034	6.53	Yes	Yes	1	1	5
78	R:R:S288	R:R:Y199	31.9501	6.36	No	Yes	1	4	5
79	R:R:S288	R:R:Y284	31.3563	6.36	No	Yes	1	4	5
80	R:R:H281	R:R:W277	18.7671	4.23	No	Yes	1	7	8
81	R:R:H281	R:R:Y219	12.0955	5.44	No	Yes	1	7	8
82	R:R:L278	R:R:Y219	15.7782	7.03	No	Yes	0	6	8
83	R:R:Q239	R:R:Y242	10.7812	5.64	No	No	5	4	3
84	R:R:N236	R:R:Q239	15.1111	3.96	No	No	0	5	4
85	R:R:F269	R:R:R138	10.1541	2.14	No	Yes	0	7	9
86	R:R:N314	R:R:V317	15.5381	2.96	Yes	No	0	9	6
87	R:R:L278	R:R:P279	11.335	3.28	No	No	0	6	9
88	R:R:N280	R:R:R308	13.0496	9.64	No	Yes	0	5	5
89	L:L:M27	R:R:N280	15.3846	7.01	Yes	No	0	0	5
90	R:R:R287	R:R:R308	15.1578	7.46	Yes	Yes	1	4	5
91	R:R:H300	R:R:R287	16.6189	7.9	Yes	Yes	0	4	4
92	R:R:H300	R:R:Y286	14.7175	3.27	Yes	No	0	4	4
93	R:R:A157	R:R:F78	26.6128	2.77	No	Yes	0	7	7
94	R:R:F108	R:R:G112	10.054	1.51	Yes	No	0	7	6
95	R:R:Y199	R:R:Y291	27.0198	21.84	Yes	Yes	1	5	1
96	L:L:?28	L:L:M27	60.3443	7	Yes	Yes	1	0	0
97	L:L:M27	R:R:C93	12.5759	4.86	Yes	Yes	1	0	7
98	R:R:E175	R:R:H210	11.3683	7.39	Yes	No	1	5	6
99	L:L:?28	R:R:R308	13.9302	15.03	Yes	Yes	1	0	5
100	R:R:F273	R:R:N314	22.2296	6.04	No	Yes	1	9	9
101	R:R:A157	R:R:L77	25.9457	1.58	No	No	0	7	6
102	R:R:F129	R:R:G125	11.1215	3.01	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I43	R:R:Y47	4.84	0	Yes	Yes	6	7	2	2
R:R:I43	R:R:Y101	4.84	0	Yes	Yes	6	4	2	1
R:R:D97	R:R:Y47	6.9	1	Yes	Yes	6	7	1	2
R:R:F312	R:R:Y47	4.13	1	Yes	Yes	7	7	1	2
R:R:C93	R:R:L89	4.76	1	Yes	Yes	7	7	1	1
R:R:L89	R:R:S123	3	1	Yes	No	7	8	1	2
R:R:L89	R:R:S315	4.5	1	Yes	No	7	8	1	2
L:L:M27	R:R:L89	7.07	1	Yes	Yes	0	7	0	1
R:R:C93	R:R:Q120	10.68	1	Yes	No	7	6	1	2
R:R:C93	R:R:F312	4.19	1	Yes	Yes	7	7	1	1
L:L:M27	R:R:C93	4.86	1	Yes	Yes	0	7	0	1
R:R:A94	R:R:F312	4.16	0	No	Yes	7	7	2	1
R:R:R100	R:R:V96	3.92	0	Yes	Yes	5	6	1	2
R:R:F108	R:R:V96	7.87	1	Yes	Yes	7	6	2	2
R:R:I116	R:R:V96	4.61	1	Yes	Yes	5	6	2	2
R:R:Q120	R:R:V96	4.3	1	No	Yes	6	6	2	2
R:R:D97	R:R:Y101	8.05	1	Yes	Yes	6	4	1	1
R:R:D97	R:R:R308	4.76	1	Yes	Yes	6	5	1	1
L:L:?28	R:R:D97	6.72	1	Yes	Yes	0	6	0	1
R:R:R100	R:R:W106	9	0	Yes	Yes	5	8	1	1
L:L:H25	R:R:R100	7.9	1	Yes	Yes	0	5	0	1
L:L:?28	R:R:R100	3.01	1	Yes	Yes	0	5	0	1
R:R:F301	R:R:Y101	6.19	1	Yes	Yes	4	4	1	1
R:R:S304	R:R:Y101	3.82	0	No	Yes	4	4	2	1
L:L:W21	R:R:Y101	14.47	1	Yes	Yes	0	4	0	1
R:R:D104	R:R:R105	4.76	0	No	No	4	4	1	2
L:L:R17	R:R:D104	5.96	0	No	No	0	4	0	1
R:R:F108	R:R:W106	15.03	1	Yes	Yes	7	8	2	1
R:R:C113	R:R:W106	5.22	1	No	Yes	9	8	2	1
R:R:C196	R:R:W106	18.28	1	No	Yes	9	8	2	1
L:L:H20	R:R:W106	3.17	1	No	Yes	0	8	0	1
R:R:F108	R:R:I116	5.02	1	Yes	Yes	7	5	2	2
R:R:C113	R:R:C196	7.28	1	No	No	9	9	2	2
R:R:I116	R:R:P117	3.39	1	Yes	Yes	5	5	2	1
R:R:I116	R:R:Q120	4.12	1	Yes	No	5	6	2	2
R:R:E175	R:R:P117	4.72	1	Yes	Yes	5	5	1	1
R:R:P117	R:R:S179	7.13	1	Yes	No	5	5	1	1
L:L:H25	R:R:P117	10.68	1	Yes	Yes	0	5	0	1
R:R:E175	R:R:P198	6.29	1	Yes	No	5	4	1	1
R:R:E175	R:R:H210	7.39	1	Yes	No	5	6	1	2
L:L:H25	R:R:E175	7.39	1	Yes	Yes	0	5	0	1
L:L:H25	R:R:S179	5.58	1	Yes	No	0	5	0	1
R:R:F184	R:R:F193	6.43	1	Yes	Yes	2	1	1	1
R:R:F184	R:R:S195	3.96	1	Yes	No	2	4	1	1
R:R:F184	R:R:H201	12.44	1	Yes	No	2	3	1	2
R:R:F184	R:R:Y291	8.25	1	Yes	Yes	2	1	1	2
R:R:F184	R:R:V294	3.93	1	Yes	No	2	5	1	1
L:L:V23	R:R:F184	19.66	1	No	Yes	0	2	0	1
R:R:E186	R:R:T189	12.7	0	No	No	3	1	1	2
R:R:E186	R:R:F193	9.33	0	No	Yes	3	1	1	1
L:L:N19	R:R:E186	13.15	0	No	No	0	3	0	1
R:R:S188	R:R:T296	3.2	0	No	No	3	3	2	1
L:L:R17	R:R:Q191	8.18	0	No	No	0	2	0	1
R:R:F193	R:R:S195	3.96	1	Yes	No	1	4	1	1
R:R:F193	R:R:V294	3.93	1	Yes	No	1	5	1	1
L:L:G18	R:R:F193	6.02	0	No	Yes	0	1	0	1
L:L:H20	R:R:F193	4.53	1	No	Yes	0	1	0	1
L:L:H20	R:R:S195	15.34	1	No	No	0	4	0	1
R:R:P198	R:R:Y199	11.13	1	No	Yes	4	5	1	2
L:L:H25	R:R:P198	12.2	1	Yes	No	0	4	0	1
R:R:S288	R:R:Y199	6.36	1	No	Yes	4	5	2	2
R:R:Y199	R:R:Y291	21.84	1	Yes	Yes	5	1	2	2
R:R:H201	R:R:Y291	21.78	1	No	Yes	3	1	2	2
R:R:H210	R:R:S214	6.97	1	No	No	6	6	2	2
R:R:H210	R:R:Y284	4.36	1	No	Yes	6	5	2	1
R:R:S211	R:R:Y284	5.09	1	No	Yes	5	5	2	1
R:R:S211	R:R:S288	6.52	1	No	No	5	4	2	2
R:R:S214	R:R:Y284	3.82	1	No	Yes	6	5	2	1
R:R:F273	R:R:W277	13.03	1	No	Yes	9	8	2	1
R:R:F273	R:R:N314	6.04	1	No	Yes	9	9	2	2
R:R:H281	R:R:W277	4.23	1	No	Yes	7	8	2	1
R:R:N314	R:R:W277	9.04	1	Yes	Yes	9	8	2	1
L:L:M27	R:R:W277	5.82	1	Yes	Yes	0	8	0	1
R:R:N280	R:R:R308	9.64	0	No	Yes	5	5	1	1
R:R:A311	R:R:N280	6.25	0	No	No	8	5	2	1
L:L:M27	R:R:N280	7.01	1	Yes	No	0	5	0	1
R:R:I283	R:R:R287	6.26	1	No	Yes	5	4	2	1
R:R:I283	R:R:R308	5.01	1	No	Yes	5	5	2	1
R:R:S288	R:R:Y284	6.36	1	No	Yes	4	5	2	1
L:L:L26	R:R:Y284	8.21	0	No	Yes	0	5	0	1
R:R:H300	R:R:Y286	3.27	0	Yes	No	4	4	1	2
R:R:H300	R:R:R287	7.9	0	Yes	Yes	4	4	1	1
R:R:R287	R:R:R308	7.46	1	Yes	Yes	4	5	1	1
L:L:V23	R:R:V294	4.81	1	No	No	0	5	0	1
L:L:N19	R:R:T296	5.85	0	No	No	0	3	0	1
R:R:H300	R:R:S304	6.97	0	Yes	No	4	4	1	2
L:L:W21	R:R:H300	5.29	1	Yes	Yes	0	4	0	1
R:R:F301	R:R:I305	7.54	1	Yes	No	4	4	1	2
L:L:W21	R:R:F301	15.03	1	Yes	Yes	0	4	0	1
L:L:?28	R:R:R308	15.03	1	Yes	Yes	0	5	0	1
L:L:M27	R:R:F312	4.98	1	Yes	Yes	0	7	0	1
R:R:G109	R:R:W106	2.81	0	No	Yes	8	8	2	1
R:R:F193	R:R:Q191	2.34	1	Yes	No	1	2	1	1
R:R:C93	R:R:T92	1.69	1	Yes	No	7	5	1	2
L:L:G24	R:R:R100	1.5	0	No	Yes	0	5	0	1
L:L:G24	R:R:R287	1.5	0	No	Yes	0	4	0	1
R:R:F301	R:R:I39	1.26	1	Yes	No	4	4	1	2
R:R:F301	R:R:M298	1.24	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W3Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	295
Number of Links	339
Number of Hubs	52
Number of Links mediated by Hubs	184
Number of Communities	5
Number of Nodes involved in Communities	72
Number of Links involved in Communities	101

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	45900
Length Of Smallest Path	3
Average Path Length	12.9356
Length of Longest Path	34
Minimum Path Strength	1.25
Average Path Strength	5.86972
Maximum Path Strength	21.81
Minimum Path Correlation	0.7
Average Path Correlation	0.934785
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	58.9316
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4173
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• transporter activity • carbohydrate transmembrane transporter activity • transmembrane transporter activity • oligosaccharide binding • binding • disaccharide binding • carbohydrate binding • maltose binding • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • cellular response to stimulus • cellular response to stress • response to stimulus • DNA damage response • response to stress • cellular process • cell chemotaxis • chemotaxis • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to stress • response to stimulus • DNA damage response • response to stress • cellular process • cell chemotaxis • chemotaxis • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • locomotion • localization • transport • carbohydrate transport • oligosaccharide transport • disaccharide transport • establishment of localization • maltose transport • polysaccharide localization • dextrin transport • macromolecule localization • maltodextrin transmembrane transport • polysaccharide transport • response to disaccharide • response to oxygen-containing compound • detection of maltose stimulus • detection of stimulus • response to carbohydrate • detection of chemical stimulus • detection of disaccharide stimulus • response to maltose • detection of carbohydrate stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • behavior • multicellular organismal process • biological process involved in intraspecies interaction between organisms • social behavior • system process • learning or memory • nervous system process • cognition • psychomotor behavior • motor behavior • cell population proliferation • regulation of cell population proliferation • response to external biotic stimulus • response to biotic stimulus • regulation of defense response • regulation of fear response • positive regulation of biological process • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • regulation of response to stress • regulation of multicellular organismal process • behavioral fear response • defense response • positive regulation of behavioral fear response • multicellular organismal response to stress • fear response • positive regulation of fear response • positive regulation of behavior • regulation of response to stimulus • positive regulation of defense response • positive regulation of multicellular organismal process • positive regulation of respiratory gaseous exchange • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • ATPase dependent transmembrane transport complex • protein-containing complex • plasma membrane protein complex • membrane • plasma membrane • membrane protein complex • transporter complex • ATP-binding cassette (ABC) transporter complex • cell periphery • cellular anatomical structure • transmembrane transporter complex • ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing • maltose transport complex • periplasmic space
Gene Ontology	Cellular Component	• ATPase dependent transmembrane transport complex • protein-containing complex • plasma membrane protein complex • membrane • plasma membrane • membrane protein complex • transporter complex • ATP-binding cassette (ABC) transporter complex • cell periphery • cellular anatomical structure • transmembrane transporter complex • ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing • maltose transport complex • periplasmic space • outer membrane-bounded periplasmic space • cell envelope • protein binding • binding • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • regulation of localization • regulation of cellular process • negative regulation of ion transmembrane transporter activity • negative regulation of potassium ion transmembrane transporter activity • negative regulation of biological process • negative regulation of transport • localization • negative regulation of voltage-gated potassium channel activity • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of potassium ion transmembrane transporter activity • regulation of biological process • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • establishment of localization • regulation of cation channel activity • inorganic cation transmembrane transport • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • potassium ion transport • regulation of potassium ion transport • negative regulation of cation channel activity • transport • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • regulation of transmembrane transporter activity • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • negative regulation of transmembrane transport • metal ion transport • regulation of transporter activity • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • regulation of metal ion transport • negative regulation of potassium ion transport • regulation of monoatomic ion transmembrane transporter activity • regulation of transport • biological regulation • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of potassium ion transmembrane transport • cellular process • regulation of monoatomic cation transmembrane transport • negative regulation of voltage-gated sodium channel activity • sodium ion transmembrane transport • regulation of sodium ion transport • regulation of sodium ion transmembrane transport • regulation of voltage-gated sodium channel activity • negative regulation of sodium ion transmembrane transport • negative regulation of sodium ion transmembrane transporter activity • regulation of sodium ion transmembrane transporter activity • negative regulation of sodium ion transport • sodium ion transport • cellular response to stimulus • response to stimulus • signaling • cell communication • G protein-coupled receptor signaling pathway • signal transduction • neuropeptide signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of response to stimulus • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • regulation of signaling • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of cell communication • regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • establishment of organelle localization • multicellular organismal process • regulated exocytosis • cellular localization • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • ossification • behavior • biological process involved in intraspecies interaction between organisms • social behavior • psychomotor behavior • motor behavior • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • regulation of defense response • regulation of fear response • regulation of behavioral fear response • regulation of behavior • behavioral defense response • regulation of response to stress • response to stress • regulation of multicellular organismal process • behavioral fear response • defense response • positive regulation of behavioral fear response • multicellular organismal response to stress • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of multicellular organismal process • cellular response to sodium phosphate • cellular response to chemical stimulus • response to chemical • response to sodium phosphate • cellular response to salt • response to salt • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of smooth muscle cell apoptotic process • smooth muscle cell apoptotic process • regulation of apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • regulation of smooth muscle cell apoptotic process • positive regulation of apoptotic process • positive regulation of muscle cell apoptotic process • vascular associated smooth muscle cell apoptotic process • positive regulation of vascular associated smooth muscle cell apoptotic process • regulation of vascular associated smooth muscle cell apoptotic process • apoptotic process • programmed cell death • positive regulation of respiratory gaseous exchange • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • positive regulation of peptide secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • regulation of peptide transport • cell-cell signaling • regulation of secretion • peptide transport • positive regulation of transport • peptide hormone secretion • hormone transport • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • cell projection • neuron projection • plasma membrane bounded cell projection • pyrophosphatase activity • enzyme regulator activity • GTPase activity • nucleoside-triphosphatase regulator activity • hydrolase activity • GTPase regulator activity • enzyme activator activity • ribonucleoside triphosphate phosphatase activity • GTPase activator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • catalytic activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • G protein-coupled receptor binding • cation binding • metal ion binding • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of protein modification process • regulation of catalytic activity • regulation of protein phosphorylation • negative regulation of phosphate metabolic process • negative regulation of catalytic activity • regulation of transferase activity • regulation of primary metabolic process • negative regulation of kinase activity • negative regulation of transferase activity • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • protein metabolic process • phosphorus metabolic process • protein modification process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • negative regulation of protein kinase activity • regulation of protein kinase activity • regulation of kinase activity • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • negative regulation of phosphorylation • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • nuclear membrane • nucleus • organelle envelope • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?28
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30550
Sequence	>7W3Z_nogp_Chain_R P G I L Y V I P A V Y G V I I L I G L I G N I T L I K I F C T V K S M R N V P N L F I S S L A L G D L L L L I T C A P V D A S R Y L A D R W L F G R I G C K L I P F I Q L T S V G V S V F T L T A L S A D R Y K A I V R P M D I Q A S H A L M K A C L K A A F I W I I S M L L A I P E A V F S D L H P F H E E S T N Q T F I S C A P Y P H S N E L H P K I H S M A S F L V F Y V I P L S I I S V Y Y Y F I A K N L I Q S A Y N L P V E G N I H V K K Q I E S R K R L A K T V L V F V G L F A F C W L P N H V I Y L Y R S Y H Y S E V D T S M L H F V T S I C A R L L A F T N S C V N P F A L Y L L S K S F R K Q F N T Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H0Q	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.3	2023-08-09	10.1038/s41422-022-00743-6
	8H0Q (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-		3.3	2023-08-09	10.1038/s41422-022-00743-6
	7W41	A	Peptide	Bombesin	BB₂	Homo sapiens	PD176252	-	-	2.95	2023-02-22	10.1073/pnas.2216230120
	7W40	A	Peptide	Bombesin	BB₂	Homo sapiens	Bombesin	-	chim(NtGi1L-Gq)/β1/γ2	3	2023-02-22	10.1073/pnas.2216230120
	7W40 (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Bombesin	-		3	2023-02-22	10.1073/pnas.2216230120
	7W3Z	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-	chim(NtGi1L-Gq)/β1/γ2	3	2023-02-22	10.1073/pnas.2216230120
	7W3Z (No Gprot)	A	Peptide	Bombesin	BB₂	Homo sapiens	Gastrin Releasing Peptide	-		3	2023-02-22	10.1073/pnas.2216230120

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