Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y47 5.71667617
2R:R:V68 3.825406
3R:R:F78 4.518507
4R:R:L82 5.306519
5R:R:D86 7.29519
6R:R:L89 3.9775417
7R:R:C93 5.79517
8R:R:V96 3.9425416
9R:R:D97 6.425416
10R:R:R100 5.28505
11R:R:Y101 9.2425414
12R:R:W106 9.76518
13R:R:F108 7.33417
14R:R:I116 4.915415
15R:R:F118 3.955406
16R:R:Q120 6.735416
17R:R:G125 3.73416
18R:R:Y139 8.0725408
19R:R:H182 4.358501
20R:R:F184 7.004512
21R:R:E186 7.434503
22R:R:P198 12.06414
23R:R:Y199 10.032515
24R:R:H206 7.4625411
25R:R:F218 4.984516
26R:R:Y219 5.5425418
27R:R:Y230 7.186528
28R:R:I233 3.224528
29R:R:V252 3.805403
30R:R:H281 7.79417
31R:R:I283 4.665415
32R:R:Y284 5.3125415
33R:R:R287 6.4725414
34R:R:Y291 10.8225411
35R:R:H300 5.48414
36R:R:F301 6.248514
37R:R:R308 5.87143715
38R:R:F312 4.3825417
39R:R:N314 6.895419
40R:R:N318 7.202519
41R:R:F333 8.1775437
42L:L:?1 5.66667610
43L:L:Q2 7.295400
44L:L:?6 7.0925410
45L:L:H7 8.40333610
46L:L:F8 7.03610
47L:L:?9 6.75571710
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I305 R:R:Y47 12.75073.63NoYes147
2R:R:R308 R:R:Y47 19.42274.12YesYes157
3R:R:F312 R:R:Y47 24.63514.13YesYes177
4R:R:A94 R:R:I51 13.13213.25NoNo077
5R:R:A94 R:R:F312 18.32094.16NoYes077
6R:R:F312 R:R:L89 29.75333.65YesYes177
7R:R:L89 R:R:S315 78.51494.5YesNo078
8R:R:L90 R:R:S315 13.56537.51NoNo068
9R:R:G54 R:R:L90 11.74311.71NoNo086
10R:R:G54 R:R:I53 14.03621.76NoNo086
11R:R:D86 R:R:S315 75.105910.31YesNo098
12R:R:D86 R:R:N58 34.00046.73YesNo099
13R:R:N58 R:R:P319 33.40244.89NoNo099
14R:R:D86 R:R:N318 39.0156.73YesYes199
15R:R:N318 R:R:P319 69.00373.26YesNo099
16R:R:F329 R:R:F333 17.69474.29NoYes097
17R:R:F329 R:R:I64 25.13893.77NoNo097
18R:R:I64 R:R:Q336 27.601510.98NoNo075
19R:R:Q336 R:R:T67 34.899712.76NoNo055
20R:R:T67 R:R:V68 39.74011.59NoYes056
21R:R:M71 R:R:V68 46.74647.61NoYes076
22R:R:M71 R:R:N76 49.12424.21NoNo078
23R:R:N73 R:R:N76 58.54138.17NoNo088
24R:R:N73 R:R:P75 60.87211.4NoNo088
25R:R:P75 R:R:V74 63.19333.53NoNo087
26R:R:D137 R:R:V74 67.61944.38NoNo087
27R:R:D137 R:R:F78 69.92657.17NoYes087
28R:R:F78 R:R:L134 87.93672.44YesNo079
29R:R:I79 R:R:L134 93.38454.28NoNo089
30R:R:I79 R:R:L61 95.04194.28NoNo089
31R:R:L61 R:R:P319 1003.28NoNo099
32R:R:A157 R:R:F78 10.16572.77NoYes077
33L:L:?9 R:R:R308 37.79088.35YesYes105
34L:L:?9 L:L:F8 81.594310.76YesYes100
35L:L:F8 R:R:V124 21.04256.55YesNo107
36R:R:G125 R:R:V124 19.70523.68YesNo167
37R:R:G125 R:R:S168 23.01063.71YesNo068
38R:R:S168 R:R:V126 20.19964.85NoNo087
39R:R:V126 R:R:W165 14.605922.07NoNo079
40L:L:F8 R:R:F218 36.3974.29YesYes106
41R:R:F218 R:R:G125 20.13844.52YesYes166
42R:R:C93 R:R:Q120 11.135710.68YesYes176
43L:L:Q2 R:R:R100 32.21584.67YesYes005
44R:R:D97 R:R:R100 11.41357.15YesYes065
45R:R:D97 R:R:Y101 13.03810.34YesYes164
46R:R:R287 R:R:R308 16.9796.4YesYes145
47L:L:?6 R:R:R100 12.72255.67YesYes005
48L:L:?1 L:L:Q2 24.87525.64YesYes000
49L:L:?9 L:L:H7 24.87053.79YesYes100
50R:R:H182 R:R:Y291 15.79723.27YesYes011
51L:L:?6 L:L:V5 11.37585.21YesNo100
52R:R:Y199 R:R:Y291 15.90559.93YesYes151
53R:R:P198 R:R:Y199 10.27416.69YesYes145
54R:R:I167 R:R:L170 11.71011.43NoNo044
55R:R:I167 R:R:L171 14.52592.85NoNo046
56R:R:F218 R:R:L171 15.93843.65YesNo066
57R:R:F129 R:R:G125 14.61533.01NoYes056
58R:R:S227 R:R:V270 58.66843.23NoNo057
59R:R:L223 R:R:S227 59.38414.5NoNo065
60R:R:F273 R:R:L223 60.82497.31NoNo096
61R:R:F273 R:R:W277 51.483213.03NoNo198
62R:R:H281 R:R:W277 91.4874.23YesNo178
63L:L:F8 R:R:H281 94.010710.18YesYes107
64R:R:L134 R:R:R138 24.25373.64NoNo099
65R:R:V270 R:R:Y230 54.63323.79NoYes078
66R:R:I233 R:R:Y139 22.33733.63YesYes088
67R:R:I233 R:R:Y230 27.06943.63YesYes288
68R:R:L322 R:R:R138 13.43823.64NoNo099
69R:R:V143 R:R:Y139 12.223412.62NoYes078
70L:L:F8 R:R:Y284 28.59033.09YesYes105
71L:L:?1 R:R:E186 13.58418.98YesYes003
72R:R:S288 R:R:Y284 17.07327.63NoYes145
73R:R:V266 R:R:Y230 33.54848.83NoYes288
74R:R:A234 R:R:V266 33.63781.7NoNo068
75R:R:A263 R:R:I238 28.81633.25NoNo064
76R:R:A234 R:R:A263 30.4361.79NoNo066
77R:R:I238 R:R:Y242 27.19184.84NoNo043
78R:R:K260 R:R:Y242 25.548515.53NoNo053
79R:R:I256 R:R:K260 23.90534.36NoNo045
80R:R:I256 R:R:V252 22.32793.07NoYes043
81R:R:L322 R:R:L325 11.5832.77NoNo097
82R:R:N314 R:R:W277 39.68369.04YesNo198
83R:R:N314 R:R:V317 15.08152.96YesNo096
84R:R:N314 R:R:N318 43.73769.54YesYes199
85R:R:C316 R:R:V317 10.94261.71NoNo076
86R:R:H290 R:R:Y286 11.60666.53NoNo024
87R:R:H300 R:R:Y286 15.41583.27YesNo144
88R:R:H300 R:R:R287 26.9477.9YesYes144
89R:R:F333 R:R:Y323 10.16579.28YesNo077
90L:L:?9 R:R:R100 47.23143.58YesYes005
91L:L:?9 R:R:C93 46.03546.23YesYes107
92R:R:R100 R:R:R287 16.30575.33YesYes054
93R:R:R138 R:R:Y230 25.92998.23NoYes098
94R:R:S288 R:R:Y199 16.8665.09NoYes145
95R:R:C93 R:R:L89 48.0934.76YesYes177
96R:R:F273 R:R:N314 10.2276.04NoYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D97 R:R:Y47 3.45 1 Yes Yes 6 7 2 2
R:R:I305 R:R:Y47 3.63 1 No Yes 4 7 2 2
R:R:R308 R:R:Y47 4.12 1 Yes Yes 5 7 1 2
R:R:F312 R:R:Y47 4.13 1 Yes Yes 7 7 2 2
R:R:C93 R:R:L89 4.76 1 Yes Yes 7 7 1 2
R:R:F312 R:R:L89 3.65 1 Yes Yes 7 7 2 2
R:R:C93 R:R:Q120 10.68 1 Yes Yes 7 6 1 1
R:R:C93 R:R:F312 5.59 1 Yes Yes 7 7 1 2
L:L:?9 R:R:C93 6.23 1 Yes Yes 0 7 0 1
R:R:F108 R:R:V96 5.24 1 Yes Yes 7 6 2 2
R:R:I116 R:R:V96 4.61 1 Yes Yes 5 6 2 2
R:R:Q120 R:R:V96 4.3 1 Yes Yes 6 6 1 2
R:R:D97 R:R:R100 7.15 1 Yes Yes 6 5 2 1
R:R:D97 R:R:Y101 10.34 1 Yes Yes 6 4 2 1
R:R:D97 R:R:R308 4.76 1 Yes Yes 6 5 2 1
R:R:R100 R:R:R287 5.33 0 Yes Yes 5 4 1 2
L:L:Q2 R:R:R100 4.67 0 Yes Yes 0 5 0 1
L:L:?6 R:R:R100 5.67 1 Yes Yes 0 5 0 1
L:L:?9 R:R:R100 3.58 1 Yes Yes 0 5 0 1
R:R:F301 R:R:Y101 5.16 1 Yes Yes 4 4 1 1
R:R:I305 R:R:Y101 6.04 1 No Yes 4 4 2 1
L:L:W3 R:R:Y101 15.43 1 No Yes 0 4 0 1
R:R:D104 R:R:F193 8.36 1 No No 4 1 1 1
L:L:?1 R:R:D104 3.45 1 Yes No 0 4 0 1
R:R:F108 R:R:W106 15.03 1 Yes Yes 7 8 2 1
R:R:C113 R:R:W106 5.22 1 No Yes 9 8 2 1
R:R:C196 R:R:W106 16.98 1 No Yes 9 8 1 1
L:L:Q2 R:R:W106 8.76 0 Yes Yes 0 8 0 1
R:R:F108 R:R:I116 7.54 1 Yes Yes 7 5 2 2
R:R:C113 R:R:C196 7.28 1 No No 9 9 2 1
R:R:I116 R:R:P117 3.39 1 Yes No 5 5 2 1
R:R:I116 R:R:Q120 4.12 1 Yes Yes 5 6 2 1
R:R:P117 R:R:S179 5.34 1 No No 5 5 1 1
L:L:H7 R:R:P117 19.83 1 Yes No 0 5 0 1
L:L:?9 R:R:Q120 7.84 1 Yes Yes 0 6 0 1
R:R:F218 R:R:L121 8.53 1 Yes No 6 4 1 1
L:L:F8 R:R:L121 7.31 1 Yes No 0 4 0 1
R:R:G125 R:R:V124 3.68 1 Yes No 6 7 2 1
R:R:F218 R:R:V124 3.93 1 Yes No 6 7 1 1
L:L:F8 R:R:V124 6.55 1 Yes No 0 7 0 1
R:R:F218 R:R:G125 4.52 1 Yes Yes 6 6 1 2
R:R:F218 R:R:L171 3.65 1 Yes No 6 6 1 2
R:R:E175 R:R:S179 5.75 0 No No 5 5 2 1
R:R:E175 R:R:P198 7.86 0 No Yes 5 4 2 1
R:R:E175 R:R:H210 7.39 0 No No 5 6 2 2
L:L:H7 R:R:S179 4.18 1 Yes No 0 5 0 1
R:R:F184 R:R:S195 5.28 1 Yes No 2 4 1 1
R:R:F184 R:R:H201 6.79 1 Yes No 2 3 1 2
R:R:F184 R:R:Y291 7.22 1 Yes Yes 2 1 1 2
R:R:F184 R:R:V294 3.93 1 Yes No 2 5 1 1
L:L:V5 R:R:F184 11.8 1 No Yes 0 2 0 1
R:R:E186 R:R:S188 5.75 0 Yes No 3 3 1 2
R:R:E186 R:R:T189 11.29 0 Yes No 3 1 1 2
R:R:E186 R:R:T296 9.88 0 Yes No 3 3 1 2
L:L:?1 R:R:E186 8.98 1 Yes Yes 0 3 0 1
L:L:?1 R:R:F193 5.16 1 Yes No 0 1 0 1
L:L:Q2 R:R:S195 10.11 0 Yes No 0 4 0 1
L:L:H7 R:R:C196 4.42 1 Yes No 0 9 0 1
R:R:P198 R:R:Y199 16.69 1 Yes Yes 4 5 1 2
L:L:?6 R:R:P198 11.49 1 Yes Yes 0 4 0 1
L:L:H7 R:R:P198 12.2 1 Yes Yes 0 4 0 1
R:R:S288 R:R:Y199 5.09 1 No Yes 4 5 2 2
R:R:Y199 R:R:Y291 9.93 1 Yes Yes 5 1 2 2
R:R:H201 R:R:Y291 22.87 1 No Yes 3 1 2 2
R:R:H210 R:R:Y284 5.44 0 No Yes 6 5 2 1
R:R:S211 R:R:Y284 5.09 1 No Yes 5 5 2 1
R:R:S211 R:R:S288 6.52 1 No No 5 4 2 2
R:R:F215 R:R:Y219 8.25 1 No Yes 6 8 2 2
R:R:F215 R:R:H281 11.31 1 No Yes 6 7 2 1
L:L:F8 R:R:F218 4.29 1 Yes Yes 0 6 0 1
R:R:H281 R:R:Y219 5.44 1 Yes Yes 7 8 1 2
R:R:H281 R:R:W277 4.23 1 Yes No 7 8 1 2
R:R:N280 R:R:R308 8.44 1 No Yes 5 5 1 1
R:R:A311 R:R:N280 4.69 0 No No 8 5 2 1
L:L:?9 R:R:N280 6.74 1 Yes No 0 5 0 1
L:L:F8 R:R:H281 10.18 1 Yes Yes 0 7 0 1
R:R:I283 R:R:R287 6.26 1 Yes Yes 5 4 2 2
R:R:I283 R:R:R308 6.26 1 Yes Yes 5 5 2 1
R:R:S288 R:R:Y284 7.63 1 No Yes 4 5 2 1
L:L:F8 R:R:Y284 3.09 1 Yes Yes 0 5 0 1
R:R:R287 R:R:R308 6.4 1 Yes Yes 4 5 2 1
L:L:V5 R:R:V294 4.81 1 No No 0 5 0 1
R:R:F301 R:R:I305 7.54 1 Yes No 4 4 1 2
L:L:W3 R:R:F301 16.04 1 No Yes 0 4 0 1
L:L:?9 R:R:R308 8.35 1 Yes Yes 0 5 0 1
R:R:G109 R:R:W106 2.81 0 No Yes 8 8 2 1
R:R:A307 R:R:R308 2.77 0 No Yes 6 5 2 1
R:R:D104 R:R:R105 2.38 1 No No 4 4 1 2
R:R:C93 R:R:T92 1.69 1 Yes No 7 5 1 2
R:R:E186 R:R:E187 1.27 0 Yes No 3 4 1 2
R:R:F301 R:R:I39 1.26 1 Yes No 4 4 1 2
R:R:F301 R:R:M298 1.24 1 Yes No 4 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7W40_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3
Number of Linked Nodes 290
Number of Links 337
Number of Hubs 47
Number of Links mediated by Hubs 165
Number of Communities 3
Number of Nodes involved in Communities 70
Number of Links involved in Communities 103
Path Summary
Number Of Nodes in MetaPath 97
Number Of Links MetaPath 96
Number of Shortest Paths 66221
Length Of Smallest Path 3
Average Path Length 14.0639
Length of Longest Path 33
Minimum Path Strength 1.25
Average Path Strength 5.78354
Maximum Path Strength 16.4967
Minimum Path Correlation 0.7
Average Path Correlation 0.936885
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 55.4442
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.7977
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDPN
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeDPN
NameD-Phenylalanine
SynonymsD-Phenylalanine
Identifier
FormulaC9 H11 N O2
Molecular Weight165.189
SMILES
PubChem71567
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6

CodeBAL
PDB ResiduesL:L:?6
Environment DetailsOpen EMBL-EBI Page
CodeBAL
Namebeta-Alanine
Synonymsω-aminopropionic acid
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem4755801
Formal Charge0
Total Atoms13
Total Chiral Atoms0
Total Bonds12
Total Aromatic Bonds0

CodeNLN
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeNLN
NameNORLEUCINE AMIDE
Synonyms2-AMINO-HEXANOIC ACID AMIDE
Identifier
FormulaC6 H14 N2 O
Molecular Weight130.188
SMILES
PubChem445699
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds22
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30550
Sequence
>7W40_nogp_Chain_R
PGILYVIPA VYGVIILIG LIGNITLIK IFCTVKSMR NVPNLFISS 
LALGDLLLL ITCAPVDAS RYLADRWLF GRIGCKLIP FIQLTSVGV 
SVFTLTALS ADRYKAIVR PMDIQASHA LMKACLKAA FIWIISMLL 
AIPEAVFSD LHPFHEEST NQTFISCAP YPHSNELHP KIHSMASFL 
VFYVIPLSI ISVYYYFIA KNLIQSAYN LPVEGNIHV KKQIESRKR 
LAKTVLVFV GLFAFCWLP NHVIYLYRS YHYSEVDTS MLHFVTSIC 
ARLLAFTNS CVNPFALYL LSKSFRKQF NTQL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8H0QAPeptideBombesinBB2Homo sapiensGastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ23.32023-08-09doi.org/10.1038/s41422-022-00743-6
8H0Q (No Gprot) APeptideBombesinBB2Homo sapiensGastrin Releasing Peptide-3.32023-08-09doi.org/10.1038/s41422-022-00743-6
7W3ZAPeptideBombesinBB2Homo sapiensGastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ232023-02-22doi.org/10.1073/pnas.2216230120
7W3Z (No Gprot) APeptideBombesinBB2Homo sapiensGastrin Releasing Peptide-32023-02-22doi.org/10.1073/pnas.2216230120
7W40APeptideBombesinBB2Homo sapiensBombesin-chim(NtGi1L-Gq)/β1/γ232023-02-22doi.org/10.1073/pnas.2216230120
7W40 (No Gprot) APeptideBombesinBB2Homo sapiensBombesin-32023-02-22doi.org/10.1073/pnas.2216230120
7W41APeptideBombesinBB2Homo sapiensPD176252--2.952023-02-22doi.org/10.1073/pnas.2216230120




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7W40_nogp.zip



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