psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F78	R:R:Q77	14.05	No	No	0	5	5
2	R:R:K332	R:R:Q77	16.27	No	No	4	1	5
3	L:L:D8	R:R:Q77	5.22	No	No	4	0	5
4	R:R:F78	R:R:Q335	5.86	No	No	0	5	3
5	L:L:F10	R:R:F78	4.29	No	No	0	0	5
6	R:R:P81	R:R:Q80	4.74	No	Yes	0	4	4
7	R:R:Q80	R:R:R84	7.01	Yes	Yes	2	4	4
8	R:R:Q80	R:R:W88	4.38	Yes	Yes	2	4	4
9	R:R:Q335	R:R:Q80	6.4	No	Yes	0	3	4
10	R:R:Q336	R:R:Q80	3.84	No	Yes	2	1	4
11	R:R:P81	R:R:W83	5.4	No	No	0	4	4
12	R:R:R84	R:R:W83	15.99	Yes	No	0	4	4
13	R:R:L87	R:R:R84	3.64	No	Yes	0	5	4
14	R:R:Q336	R:R:R84	3.5	No	Yes	2	1	4
15	R:R:I85	R:R:L147	8.56	No	No	5	3	4
16	R:R:H148	R:R:I85	3.98	No	No	5	4	3
17	R:R:W88	R:R:Y92	6.75	Yes	Yes	2	4	7
18	R:R:Q336	R:R:W88	12.05	No	Yes	2	1	4
19	R:R:L339	R:R:W88	12.53	No	Yes	2	3	4
20	R:R:F143	R:R:S89	5.28	Yes	No	0	7	5
21	R:R:F143	R:R:Y92	14.44	Yes	Yes	0	7	7
22	R:R:L339	R:R:Y92	7.03	No	Yes	2	3	7
23	R:R:W343	R:R:Y92	12.54	No	Yes	0	5	7
24	R:R:V95	R:R:W343	3.68	No	No	0	8	5
25	R:R:M350	R:R:V95	4.56	No	No	0	7	8
26	R:R:V100	R:R:V96	4.81	Yes	No	0	6	6
27	R:R:M350	R:R:V98	6.09	No	No	0	7	5
28	R:R:G102	R:R:P353	4.06	No	No	0	8	9
29	R:R:D131	R:R:N103	5.39	Yes	No	0	9	9
30	R:R:N103	R:R:P353	8.15	No	No	0	9	9
31	R:R:I105	R:R:W108	4.7	No	Yes	0	7	4
32	R:R:F367	R:R:I105	5.02	No	No	0	6	7
33	R:R:F363	R:R:V106	6.55	No	No	0	8	9
34	R:R:I107	R:R:V125	4.61	No	No	0	7	6
35	R:R:F363	R:R:I109	5.02	No	No	0	8	7
36	R:R:G366	R:R:I109	3.53	No	No	0	6	7
37	R:R:I110	R:R:N121	9.91	No	No	0	7	8
38	R:R:I110	R:R:V125	6.14	No	No	0	7	6
39	R:R:H113	R:R:M116	3.94	No	No	0	5	7
40	R:R:K114	R:R:R117	19.8	No	No	0	6	7
41	R:R:M116	R:R:R362	6.2	No	No	0	7	6
42	R:R:T118	R:R:T120	4.71	No	No	0	8	8
43	R:R:R194	R:R:V119	3.92	No	No	0	5	7
44	R:R:N121	R:R:T120	5.85	No	No	0	8	8
45	R:R:R194	R:R:T120	11.64	No	No	0	5	8
46	R:R:L124	R:R:N121	4.12	No	No	0	8	8
47	R:R:A178	R:R:F123	4.16	No	Yes	0	6	8
48	R:R:F123	R:R:I179	3.77	Yes	No	0	8	9
49	R:R:D182	R:R:F123	4.78	No	Yes	0	8	8
50	R:R:F123	R:R:T200	6.49	Yes	No	0	8	7
51	R:R:L124	R:R:Y356	11.72	No	Yes	0	8	9
52	R:R:N126	R:R:S175	7.45	No	No	0	9	7
53	R:R:I204	R:R:N126	12.74	No	No	0	8	9
54	R:R:N126	R:R:W208	6.78	No	Yes	0	9	9
55	R:R:D131	R:R:L127	10.86	Yes	Yes	6	9	9
56	R:R:L127	R:R:S175	4.5	Yes	No	0	9	7
57	R:R:L127	R:R:N352	9.61	Yes	No	6	9	9
58	R:R:F129	R:R:S133	5.28	No	No	0	6	7
59	R:R:S130	R:R:S172	4.89	No	No	0	8	9
60	R:R:D131	R:R:S172	7.36	Yes	No	0	9	9
61	R:R:D131	R:R:N352	4.04	Yes	No	6	9	9
62	R:R:F164	R:R:S133	7.93	Yes	No	0	5	7
63	R:R:M134	R:R:V169	4.56	Yes	No	0	7	7
64	R:R:M134	R:R:S172	6.13	Yes	No	0	7	9
65	R:R:M134	R:R:M346	4.33	Yes	No	0	7	7
66	R:R:M134	R:R:T349	6.02	Yes	No	0	7	9
67	R:R:F137	R:R:F164	4.29	No	Yes	0	5	5
68	R:R:N138	R:R:N142	4.09	No	Yes	1	7	6
69	R:R:N138	R:R:P165	4.89	No	No	0	7	6
70	R:R:F342	R:R:N138	4.83	Yes	No	1	6	7
71	R:R:F342	R:R:T139	3.89	Yes	No	1	6	7
72	R:R:M346	R:R:T139	6.02	No	No	1	7	7
73	R:R:F153	R:R:V141	7.87	Yes	No	1	7	5
74	R:R:V141	R:R:Y157	7.57	No	Yes	1	5	6
75	R:R:Q161	R:R:V141	8.6	Yes	No	1	5	5
76	R:R:N142	R:R:Q161	9.24	Yes	Yes	1	6	5
77	R:R:F342	R:R:N142	4.83	Yes	Yes	1	6	6
78	L:L:L13	R:R:N142	5.49	Yes	Yes	1	0	6
79	R:R:F143	R:R:L147	13.4	Yes	No	0	7	4
80	R:R:S149	R:R:Y145	3.82	No	Yes	0	4	4
81	R:R:W151	R:R:Y145	14.47	Yes	Yes	1	8	4
82	R:R:F234	R:R:Y145	4.13	Yes	Yes	1	4	4
83	L:L:L13	R:R:Y145	4.69	Yes	Yes	1	0	4
84	R:R:A146	R:R:L339	4.73	No	No	0	4	3
85	R:R:H148	R:R:L147	6.43	No	No	5	4	4
86	R:R:E150	R:R:H148	3.69	No	No	0	4	4
87	R:R:E150	R:R:R230	3.49	No	No	0	4	3
88	R:R:F153	R:R:W151	4.01	Yes	Yes	1	7	8
89	R:R:C158	R:R:W151	3.92	Yes	Yes	1	9	8
90	R:R:C233	R:R:W151	5.22	No	Yes	0	9	8
91	R:R:F234	R:R:W151	12.03	Yes	Yes	1	4	8
92	R:R:F153	R:R:Y157	5.16	Yes	Yes	1	7	6
93	R:R:F160	R:R:Y157	8.25	No	Yes	0	5	6
94	R:R:Q161	R:R:Y157	4.51	Yes	Yes	1	5	6
95	R:R:C158	R:R:S222	5.16	Yes	Yes	1	9	5
96	R:R:C158	R:R:T224	5.07	Yes	No	0	9	5
97	R:R:C158	R:R:F234	13.97	Yes	Yes	1	9	4
98	R:R:R159	R:R:S222	3.95	No	Yes	0	7	5
99	R:R:F160	R:R:F164	7.5	No	Yes	0	5	5
100	R:R:P165	R:R:Q161	9.47	No	Yes	0	6	5
101	R:R:F234	R:R:Q161	4.68	Yes	Yes	1	4	5
102	R:R:I166	R:R:N162	4.25	Yes	Yes	1	4	5
103	R:R:N162	R:R:S222	4.47	Yes	Yes	1	5	5
104	R:R:F234	R:R:N162	15.71	Yes	Yes	1	4	5
105	L:L:L13	R:R:N162	8.24	Yes	Yes	1	0	5
106	R:R:F163	R:R:F212	8.57	No	No	0	6	4
107	R:R:F163	R:R:F216	6.43	No	No	0	6	4
108	R:R:C219	R:R:F163	9.78	No	No	0	5	6
109	R:R:F164	R:R:T167	3.89	Yes	Yes	3	5	5
110	R:R:F164	R:R:W208	4.01	Yes	Yes	3	5	9
111	R:R:F170	R:R:I166	3.77	Yes	Yes	0	6	4
112	R:R:I166	R:R:Q218	6.86	Yes	No	1	4	5
113	L:L:M14	R:R:I166	4.37	Yes	Yes	1	0	4
114	R:R:T167	R:R:W208	4.85	Yes	Yes	3	5	9
115	R:R:F212	R:R:T167	15.56	No	Yes	3	4	5
116	R:R:F170	R:R:V169	3.93	Yes	No	0	6	7
117	R:R:V169	R:R:W312	3.68	No	Yes	0	7	8
118	R:R:F170	R:R:L214	8.53	Yes	No	0	6	5
119	R:R:F170	R:R:V255	9.18	Yes	No	0	6	6
120	R:R:A171	R:R:W208	10.37	No	Yes	0	7	9
121	R:R:F308	R:R:I173	6.28	No	No	1	9	7
122	R:R:I173	R:R:W312	11.74	No	Yes	1	7	8
123	R:R:I207	R:R:Y174	3.63	No	No	0	7	6
124	R:R:L254	R:R:Y174	3.52	No	No	0	4	6
125	R:R:V255	R:R:Y174	3.79	No	No	0	6	6
126	R:R:M176	R:R:M263	4.33	No	No	0	8	8
127	R:R:P259	R:R:T177	3.5	No	No	0	9	7
128	R:R:I262	R:R:T177	4.56	No	No	0	6	7
129	R:R:I179	R:R:R183	7.52	No	No	0	9	9
130	R:R:A180	R:R:Y267	5.34	No	No	0	9	9
131	R:R:D182	R:R:R194	7.15	No	No	0	8	5
132	R:R:R183	R:R:Y267	8.23	No	No	0	9	9
133	R:R:R183	R:R:Y356	4.12	No	Yes	0	9	9
134	R:R:I188	R:R:Y184	12.09	No	No	0	7	8
135	R:R:T266	R:R:Y184	7.49	No	No	0	7	8
136	R:R:I269	R:R:Y184	4.84	No	No	0	4	8
137	R:R:I187	R:R:V270	4.61	No	No	0	8	8
138	R:R:I187	R:R:L274	7.14	No	No	0	8	8
139	R:R:D189	R:R:K192	16.59	Yes	No	0	5	5
140	R:R:S196	R:R:T198	4.8	No	No	0	7	5
141	R:R:I204	R:R:K201	5.82	No	No	0	8	3
142	R:R:G205	R:R:I204	3.53	No	No	0	4	8
143	R:R:F212	R:R:W208	5.01	No	Yes	3	4	9
144	R:R:L214	R:R:Y247	3.52	No	Yes	1	5	6
145	R:R:L214	R:R:V251	4.47	No	No	1	5	5
146	R:R:Q218	R:R:Y247	10.15	No	Yes	1	5	6
147	L:L:M14	R:R:Q218	12.23	Yes	No	1	0	5
148	R:R:L220	R:R:Y221	7.03	No	No	0	4	4
149	R:R:P238	R:R:Y221	5.56	No	No	0	4	4
150	R:R:F234	R:R:S222	10.57	Yes	Yes	1	4	5
151	R:R:K223	R:R:K225	4.31	No	No	8	4	1
152	R:R:K223	R:R:P238	10.04	No	No	8	4	4
153	R:R:K225	R:R:P238	5.02	No	No	8	1	4
154	R:R:C233	R:R:V226	6.83	No	No	0	9	2
155	L:L:D9	R:R:L232	8.14	No	No	0	0	3
156	L:L:L13	R:R:F234	19.49	Yes	Yes	1	0	4
157	L:L:F11	R:R:V235	9.18	Yes	No	0	0	4
158	R:R:H244	R:R:Q236	6.18	Yes	No	0	5	3
159	L:L:F11	R:R:Q236	9.37	Yes	No	0	0	3
160	R:R:Q243	R:R:W237	6.57	No	Yes	0	2	5
161	R:R:H244	R:R:W237	22.22	Yes	Yes	0	5	5
162	R:R:W237	R:R:Y247	8.68	Yes	Yes	0	5	6
163	R:R:E239	R:R:G240	4.91	No	No	0	4	4
164	R:R:E239	R:R:Q243	8.92	No	No	0	4	2
165	R:R:G240	R:R:P241	4.06	No	No	0	4	2
166	R:R:F245	R:R:K242	3.72	Yes	No	0	3	1
167	R:R:H244	R:R:H248	5.97	Yes	Yes	0	5	5
168	R:R:A323	R:R:H244	8.78	No	Yes	0	4	5
169	R:R:F245	R:R:I249	8.79	Yes	No	0	3	4
170	R:R:F245	R:R:I324	6.28	Yes	No	0	3	5
171	R:R:H248	R:R:Y247	7.62	Yes	Yes	1	5	6
172	R:R:V251	R:R:Y247	7.57	No	Yes	1	5	6
173	R:R:F319	R:R:H248	9.05	Yes	Yes	1	5	5
174	L:L:M14	R:R:H248	3.94	Yes	Yes	1	0	5
175	R:R:I252	R:R:Y256	3.63	No	No	0	5	8
176	R:R:H316	R:R:I252	7.95	No	No	0	7	5
177	R:R:I252	R:R:I320	4.42	No	No	0	5	5
178	R:R:L260	R:R:Y256	3.52	No	No	0	6	8
179	R:R:L313	R:R:Y256	8.21	No	No	0	6	8
180	R:R:F258	R:R:L261	6.09	No	No	0	5	3
181	R:R:F258	R:R:I262	11.3	No	No	0	5	6
182	R:R:F308	R:R:L260	4.87	No	No	0	9	6
183	R:R:A309	R:R:L260	4.73	No	No	0	5	6
184	R:R:M301	R:R:Y267	17.96	Yes	No	0	8	9
185	R:R:G271	R:R:V298	3.68	No	No	0	5	6
186	R:R:K294	R:R:L274	7.05	No	No	0	7	8
187	R:R:L274	R:R:V297	4.47	No	No	0	8	7
188	R:R:R295	R:R:W275	25.99	No	No	0	4	5
189	R:R:K294	R:R:Q290	6.78	No	No	0	7	4
190	R:R:K294	R:R:L291	5.64	No	No	0	7	2
191	R:R:L291	R:R:R295	4.86	No	No	0	2	4
192	R:R:M300	R:R:M301	4.33	Yes	Yes	0	8	8
193	R:R:I355	R:R:M300	4.37	No	Yes	0	8	8
194	R:R:L359	R:R:M300	4.24	No	Yes	0	7	8
195	R:R:T307	R:R:Y351	9.99	No	No	0	7	6
196	R:R:F308	R:R:W312	11.02	No	Yes	1	9	8
197	R:R:C311	R:R:L344	4.76	No	No	0	8	7
198	R:R:W312	R:R:Y315	7.72	Yes	Yes	1	8	6
199	R:R:A345	R:R:W312	7.78	No	Yes	1	8	8
200	R:R:S348	R:R:W312	4.94	No	Yes	0	9	8
201	R:R:H316	R:R:Y315	7.62	No	Yes	0	7	6
202	R:R:F319	R:R:Y315	7.22	Yes	Yes	1	5	6
203	R:R:F342	R:R:Y315	4.13	Yes	Yes	1	6	6
204	R:R:A345	R:R:Y315	5.34	No	Yes	1	8	6
205	L:L:M14	R:R:Y315	7.18	Yes	Yes	1	0	6
206	R:R:F319	R:R:Y318	9.28	Yes	Yes	1	5	4
207	R:R:T322	R:R:Y318	6.24	No	Yes	0	4	4
208	R:R:I334	R:R:Y318	6.04	Yes	Yes	0	3	4
209	R:R:Y318	R:R:Y338	11.91	Yes	Yes	1	4	4
210	L:L:M14	R:R:F319	9.95	Yes	Yes	1	0	5
211	R:R:N329	R:R:T322	7.31	No	No	0	2	4
212	R:R:I324	R:R:Y325	6.04	No	No	0	5	2
213	L:L:F11	R:R:N329	3.62	Yes	No	0	0	2
214	L:L:D9	R:R:R330	9.53	No	No	0	0	1
215	R:R:W331	R:R:Y333	5.79	No	No	0	1	4
216	L:L:D8	R:R:K332	8.3	No	No	4	0	1
217	L:L:F10	R:R:I334	3.77	No	Yes	0	0	3
218	R:R:F342	R:R:Y338	13.41	Yes	Yes	1	6	4
219	L:L:F10	R:R:Y338	6.19	No	Yes	0	0	4
220	R:R:F342	R:R:M346	9.95	Yes	No	1	6	7
221	R:R:L344	R:R:W343	5.69	No	No	0	7	5
222	R:R:S347	R:R:Y351	3.82	No	No	0	5	6
223	R:R:S348	R:R:Y351	3.82	No	No	0	9	6
224	R:R:N352	R:R:Y356	3.49	No	Yes	0	9	9
225	R:R:F363	R:R:Y356	6.19	No	Yes	0	8	9
226	R:R:C357	R:R:F367	8.38	No	No	0	7	6
227	R:R:K361	R:R:N360	9.79	No	No	7	4	8
228	R:R:N360	R:R:R362	10.85	No	No	7	8	6
229	R:R:K361	R:R:R362	13.61	No	No	7	4	6
230	R:R:K361	R:R:R364	3.71	No	No	0	4	9
231	L:L:D9	L:L:F11	5.97	No	Yes	0	0	0
232	R:R:A199	R:R:S196	3.42	No	No	0	4	7
233	R:R:A197	R:R:V119	3.39	No	No	0	3	7
234	R:R:I173	R:R:P259	3.39	No	No	0	7	9
235	R:R:A99	R:R:T349	3.36	No	No	0	8	9
236	R:R:A155	R:R:T224	3.36	No	No	0	2	5
237	R:R:A211	R:R:T167	3.36	No	Yes	0	8	5
238	R:R:M227	R:R:P228	3.35	No	No	0	1	1
239	R:R:A128	R:R:I107	3.25	No	No	0	9	7
240	R:R:A215	R:R:I166	3.25	No	Yes	0	7	4
241	R:R:S149	R:R:T231	3.2	No	No	0	4	4
242	R:R:H113	R:R:W108	3.17	No	Yes	0	5	4
243	R:R:I334	R:R:V337	3.07	Yes	No	0	3	5
244	R:R:I187	R:R:T273	3.04	No	No	0	8	4
245	R:R:I188	R:R:T273	3.04	No	No	0	7	4
246	R:R:I262	R:R:T266	3.04	No	No	0	6	7
247	R:R:M263	R:R:V305	3.04	No	No	0	8	8
248	R:R:M301	R:R:V270	3.04	Yes	No	0	8	8
249	R:R:M301	R:R:V297	3.04	Yes	No	0	8	7
250	R:R:M300	R:R:V304	3.04	Yes	No	0	8	8
251	R:R:I303	R:R:T307	3.04	No	No	0	6	7
252	R:R:L210	R:R:S206	3	No	No	0	4	3
253	R:R:N76	R:R:T231	2.92	No	No	0	5	4
254	R:R:I109	R:R:M116	2.92	No	No	0	7	7
255	R:R:I354	R:R:M350	2.92	No	No	0	6	7
256	L:L:G12	R:R:Y338	2.9	No	Yes	0	0	4
257	R:R:I107	R:R:L111	2.85	No	No	0	7	3
258	R:R:I253	R:R:L254	2.85	No	No	0	4	4
259	R:R:I317	R:R:L313	2.85	No	No	0	5	6
260	R:R:I317	R:R:L321	2.85	No	No	0	5	4
261	R:R:L127	R:R:M176	2.83	Yes	No	0	9	8
262	R:R:K296	R:R:L359	2.82	No	No	0	7	7
263	R:R:D189	R:R:I188	2.8	Yes	No	0	5	7
264	R:R:D189	R:R:M185	2.77	Yes	No	0	5	4
265	R:R:P217	R:R:W237	2.7	No	Yes	0	7	5
266	R:R:L328	R:R:Q327	2.66	No	No	0	5	3
267	R:R:F123	R:R:V203	2.62	Yes	No	0	8	6
268	R:R:A112	R:R:W108	2.59	No	Yes	0	6	4
269	R:R:S341	R:R:Y318	2.54	No	Yes	1	6	4
270	R:R:S341	R:R:Y338	2.54	No	Yes	1	6	4
271	R:R:F245	R:R:I320	2.51	Yes	No	0	3	5
272	R:R:T200	R:R:Y122	2.5	No	No	0	7	5
273	R:R:V298	R:R:W275	2.45	No	No	0	6	5
274	R:R:I250	R:R:Y247	2.42	No	Yes	0	4	6
275	R:R:I334	R:R:W331	2.35	Yes	No	0	3	1
276	R:R:L328	R:R:W331	2.28	No	No	0	5	1
277	R:R:E239	R:R:Y221	2.24	No	No	0	4	4
278	R:R:A135	R:R:A99	1.79	No	No	0	6	8
279	R:R:P314	R:R:S341	1.78	No	No	0	9	6
280	R:R:A168	R:R:S133	1.71	No	No	0	8	7
281	R:R:A135	R:R:V100	1.7	No	Yes	0	6	6
282	R:R:A136	R:R:V100	1.7	No	Yes	0	5	6
283	R:R:K192	R:R:P193	1.67	No	No	0	5	6
284	R:R:D189	R:R:P190	1.61	Yes	No	0	5	8
285	R:R:T266	R:R:V181	1.59	No	No	0	7	5
286	R:R:C358	R:R:L359	1.59	No	No	0	6	7
287	R:R:A97	R:R:L101	1.58	No	No	0	5	5
288	R:R:A199	R:R:L195	1.58	No	No	0	4	5
289	R:R:P241	R:R:Q326	1.58	No	No	0	2	2
290	R:R:A132	R:R:N103	1.56	No	No	0	7	9
291	R:R:K242	R:R:T246	1.5	No	No	0	1	4
292	R:R:L101	R:R:V100	1.49	No	Yes	0	5	6
293	R:R:L104	R:R:V100	1.49	No	Yes	0	3	6
294	R:R:I265	R:R:I269	1.47	No	No	0	4	4
295	R:R:I302	R:R:M306	1.46	No	No	0	5	5
296	R:R:L232	R:R:M227	1.41	No	No	0	3	1
297	R:R:A91	R:R:Y92	1.33	No	Yes	0	5	7
298	R:R:A340	R:R:W88	1.3	No	Yes	0	5	4
299	R:R:F143	R:R:I144	1.26	Yes	No	0	7	4
300	R:R:F153	R:R:I144	1.26	Yes	No	0	7	4
301	R:R:K299	R:R:W275	1.16	No	No	0	6	5
302	R:R:R117	R:R:Y122	1.03	No	No	0	7	5
303	R:R:F153	R:R:Y152	1.03	Yes	No	0	7	3
304	R:R:R369	R:R:W108	1	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q80	5.274	5	2	4
2	R:R:R84	7.535	4	2	4
3	R:R:W88	7.402	5	2	4
4	R:R:Y92	8.418	5	2	7
5	R:R:V100	2.238	5	0	6
6	R:R:W108	2.865	4	0	4
7	R:R:F123	4.364	5	0	8
8	R:R:L127	6.95	4	6	9
9	R:R:D131	6.9125	4	6	9
10	R:R:M134	5.26	4	0	7
11	R:R:N142	5.9125	4	1	6
12	R:R:F143	8.595	4	0	7
13	R:R:Y145	6.7775	4	1	4
14	R:R:W151	7.93	5	1	8
15	R:R:F153	3.866	5	1	7
16	R:R:Y157	6.3725	4	1	6
17	R:R:C158	7.03	4	1	9
18	R:R:Q161	7.3	5	1	5
19	R:R:N162	8.1675	4	1	5
20	R:R:F164	5.524	5	3	5
21	R:R:I166	4.5	5	1	4
22	R:R:T167	6.915	4	3	5
23	R:R:F170	6.3525	4	0	6
24	R:R:D189	5.9425	4	0	5
25	R:R:W208	6.204	5	3	9
26	R:R:S222	6.0375	4	1	5
27	R:R:F234	11.5114	7	1	4
28	R:R:W237	10.0425	4	0	5
29	R:R:H244	10.7875	4	0	5
30	R:R:F245	5.325	4	0	3
31	R:R:Y247	6.66	6	1	6
32	R:R:H248	6.645	4	1	5
33	R:R:M300	3.995	4	0	8
34	R:R:M301	7.0925	4	0	8
35	R:R:W312	7.81333	6	1	8
36	R:R:Y315	6.535	6	1	6
37	R:R:Y318	7.202	5	1	4
38	R:R:F319	8.875	4	1	5
39	R:R:I334	3.8075	4	0	3
40	R:R:Y338	7.39	5	1	4
41	R:R:F342	6.84	6	1	6
42	R:R:Y356	6.38	4	0	9
43	L:L:F11	7.035	4	0	0
44	L:L:L13	9.4775	4	1	0
45	L:L:M14	7.534	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F78	R:R:Q335	31.3194	5.86	No	No	0	5	3
2	R:R:Q335	R:R:Q80	29.3527	6.4	No	Yes	0	3	4
3	R:R:Q80	R:R:W88	18.0969	4.38	Yes	Yes	2	4	4
4	R:R:W88	R:R:Y92	14.4606	6.75	Yes	Yes	2	4	7
5	R:R:F143	R:R:Y92	27.3576	14.44	Yes	Yes	0	7	7
6	R:R:F143	R:R:L147	13.2083	13.4	Yes	No	0	7	4
7	R:R:W343	R:R:Y92	20.3608	12.54	No	Yes	0	5	7
8	R:R:V95	R:R:W343	11.6378	3.68	No	No	0	8	5
9	L:L:F10	R:R:F78	39.9788	4.29	No	No	0	0	5
10	L:L:F10	R:R:Y338	39.1227	6.19	No	Yes	0	0	4
11	R:R:F342	R:R:Y338	52.7839	13.41	Yes	Yes	1	6	4
12	R:R:F342	R:R:M346	60.4669	9.95	Yes	No	1	6	7
13	R:R:M134	R:R:M346	60.3042	4.33	Yes	No	0	7	7
14	R:R:M134	R:R:T349	21.7687	6.02	Yes	No	0	7	9
15	R:R:A99	R:R:T349	19.4057	3.36	No	No	0	8	9
16	R:R:A135	R:R:A99	17.0287	1.79	No	No	0	6	8
17	R:R:A135	R:R:V100	14.6374	1.7	No	Yes	0	6	6
18	R:R:M134	R:R:S172	100	6.13	Yes	No	0	7	9
19	R:R:D131	R:R:S172	97.7644	7.36	Yes	No	0	9	9
20	R:R:D131	R:R:N103	10.2936	5.39	Yes	No	0	9	9
21	R:R:D131	R:R:N352	78.8256	4.04	Yes	No	6	9	9
22	R:R:N352	R:R:Y356	99.5402	3.49	No	Yes	0	9	9
23	R:R:F363	R:R:Y356	34.2059	6.19	No	Yes	0	8	9
24	R:R:F363	R:R:I109	30.2794	5.02	No	No	0	8	7
25	R:R:I109	R:R:M116	26.3247	2.92	No	No	0	7	7
26	R:R:H113	R:R:M116	15.4581	3.94	No	No	0	5	7
27	R:R:H113	R:R:W108	13.2437	3.17	No	Yes	0	5	4
28	R:R:L124	R:R:Y356	24.167	11.72	No	Yes	0	8	9
29	R:R:L124	R:R:N121	22.271	4.12	No	No	0	8	8
30	R:R:I110	R:R:N121	11.0435	9.91	No	No	0	7	8
31	R:R:R183	R:R:Y356	57.538	4.12	No	Yes	0	9	9
32	R:R:I179	R:R:R183	19.0732	7.52	No	No	0	9	9
33	R:R:F123	R:R:I179	16.9367	3.77	Yes	No	0	8	9
34	R:R:N121	R:R:T120	10.0035	5.85	No	No	0	8	8
35	R:R:F342	R:R:N142	59.9505	4.83	Yes	Yes	1	6	6
36	R:R:N142	R:R:Q161	43.0704	9.24	Yes	Yes	1	6	5
37	R:R:Q161	R:R:Y157	30.7888	4.51	Yes	Yes	1	5	6
38	R:R:F160	R:R:Y157	39.0096	8.25	No	Yes	0	5	6
39	R:R:F160	R:R:F164	38.295	7.5	No	Yes	0	5	5
40	R:R:F164	R:R:W208	27.6901	4.01	Yes	Yes	3	5	9
41	R:R:N126	R:R:W208	26.9119	6.78	No	Yes	0	9	9
42	R:R:D131	R:R:L127	14.1563	10.86	Yes	Yes	6	9	9
43	R:R:L127	R:R:S175	30.4988	4.5	Yes	No	0	9	7
44	R:R:N126	R:R:S175	29.381	7.45	No	No	0	9	7
45	R:R:F342	R:R:Y315	52.2745	4.13	Yes	Yes	1	6	6
46	R:R:W312	R:R:Y315	63.6434	7.72	Yes	Yes	1	8	6
47	R:R:V169	R:R:W312	32.6495	3.68	No	Yes	0	7	8
48	R:R:M134	R:R:V169	53.7531	4.56	Yes	No	0	7	7
49	R:R:F153	R:R:V141	10.7676	7.87	Yes	No	1	7	5
50	R:R:Q161	R:R:V141	11.9491	8.6	Yes	No	1	5	5
51	R:R:F153	R:R:Y157	29.5578	5.16	Yes	Yes	1	7	6
52	R:R:F153	R:R:I144	42.0658	1.26	Yes	No	0	7	4
53	R:R:F143	R:R:I144	40.0495	1.26	Yes	No	0	7	4
54	L:L:L13	R:R:N142	17.2055	5.49	Yes	Yes	1	0	6
55	R:R:F234	R:R:Q161	15.1044	4.68	Yes	Yes	1	4	5
56	R:R:F234	R:R:W151	17.1631	12.03	Yes	Yes	1	4	8
57	R:R:C158	R:R:F234	11.6873	13.97	Yes	Yes	1	9	4
58	R:R:C233	R:R:W151	11.185	5.22	No	Yes	0	9	8
59	R:R:C158	R:R:T224	11.6944	5.07	Yes	No	0	9	5
60	L:L:F10	R:R:I334	15.2388	3.77	No	Yes	0	0	3
61	R:R:I334	R:R:Y318	18.9105	6.04	Yes	Yes	0	3	4
62	R:R:F319	R:R:Y318	21.3866	9.28	Yes	Yes	1	5	4
63	L:L:M14	R:R:I166	16.4768	4.37	Yes	Yes	1	0	4
64	R:R:Y318	R:R:Y338	24.7117	11.91	Yes	Yes	1	4	4
65	L:L:M14	R:R:Y315	31.56	7.18	Yes	Yes	1	0	6
66	R:R:F163	R:R:F212	10.2865	8.57	No	No	0	6	4
67	R:R:F170	R:R:I166	22.5115	3.77	Yes	Yes	0	6	4
68	R:R:F170	R:R:V169	39.3987	3.93	Yes	No	0	6	7
69	R:R:F319	R:R:H248	29.2749	9.05	Yes	Yes	1	5	5
70	R:R:H248	R:R:Y247	18.4931	7.62	Yes	Yes	1	5	6
71	R:R:L214	R:R:Y247	17.4531	3.52	No	Yes	1	5	6
72	R:R:F170	R:R:V255	12.8334	9.18	Yes	No	0	6	6
73	R:R:F308	R:R:W312	10.4563	11.02	No	Yes	1	9	8
74	R:R:I173	R:R:W312	46.3459	11.74	No	Yes	1	7	8
75	R:R:V255	R:R:Y174	10.2936	3.79	No	No	0	6	6
76	R:R:I173	R:R:P259	46.9402	3.39	No	No	0	7	9
77	R:R:P259	R:R:T177	44.4641	3.5	No	No	0	9	7
78	R:R:I262	R:R:T177	42.0587	4.56	No	No	0	6	7
79	R:R:R183	R:R:Y267	42.9926	8.23	No	No	0	9	9
80	R:R:I262	R:R:T266	35.6491	3.04	No	No	0	6	7
81	R:R:T266	R:R:Y184	31.6873	7.49	No	No	0	7	8
82	R:R:I188	R:R:Y184	26.6572	12.09	No	No	0	7	8
83	R:R:I188	R:R:T273	17.0145	3.04	No	No	0	7	4
84	R:R:I187	R:R:T273	15.6279	3.04	No	No	0	8	4
85	R:R:M301	R:R:Y267	39.7595	17.96	Yes	No	0	8	9
86	R:R:M301	R:R:V270	10.8383	3.04	Yes	No	0	8	8
87	R:R:M301	R:R:V297	16.2646	3.04	Yes	No	0	8	7
88	R:R:L274	R:R:V297	14.4252	4.47	No	No	0	8	7
89	R:R:D189	R:R:I188	14.4959	2.8	Yes	No	0	5	7
90	R:R:H244	R:R:H248	36.3	5.97	Yes	Yes	0	5	5
91	R:R:H244	R:R:W237	15.9321	22.22	Yes	Yes	0	5	5
92	R:R:Q243	R:R:W237	39.0096	6.57	No	Yes	0	2	5
93	R:R:E239	R:R:Q243	35.1539	8.92	No	No	0	4	2
94	R:R:E239	R:R:Y221	19.5897	2.24	No	No	0	4	4
95	R:R:W237	R:R:Y247	35.5218	8.68	Yes	Yes	0	5	6
96	R:R:P238	R:R:Y221	11.7227	5.56	No	No	0	4	4
97	L:L:D9	L:L:F11	16.5122	5.97	No	Yes	0	0	0
98	L:L:F11	R:R:N329	14.2695	3.62	Yes	No	0	0	2
99	R:R:N329	R:R:T322	16.307	7.31	No	No	0	2	4
100	R:R:T322	R:R:Y318	18.578	6.24	No	Yes	0	4	4
101	R:R:H244	R:R:Q236	14.977	6.18	Yes	No	0	5	3
102	L:L:F11	R:R:Q236	10.0035	9.37	Yes	No	0	0	3
103	R:R:E239	R:R:G240	11.8995	4.91	No	No	0	4	4
104	R:R:F245	R:R:I320	21.047	2.51	Yes	No	0	3	5
105	R:R:I252	R:R:I320	24.4995	4.42	No	No	0	5	5
106	R:R:H316	R:R:I252	32.9183	7.95	No	No	0	7	5
107	R:R:H316	R:R:Y315	36.0594	7.62	No	Yes	0	7	6
108	R:R:F308	R:R:L260	10.8383	4.87	No	No	0	9	6
109	R:R:K294	R:R:L274	18.2172	7.05	No	No	0	7	8
110	R:R:K294	R:R:L291	13.746	5.64	No	No	0	7	2
111	R:R:L291	R:R:R295	11.4892	4.86	No	No	0	2	4
112	R:R:M300	R:R:M301	13.3357	4.33	Yes	Yes	0	8	8
113	R:R:S348	R:R:W312	14.5313	4.94	No	Yes	0	9	8
114	R:R:S348	R:R:Y351	11.6519	3.82	No	No	0	9	6
115	R:R:I334	R:R:W331	12.7839	2.35	Yes	No	0	3	1
116	R:R:F153	R:R:W151	12.6424	4.01	Yes	Yes	1	7	8
117	R:R:F234	R:R:N162	21.7191	15.71	Yes	Yes	1	4	5
118	R:R:I166	R:R:N162	31.4609	4.25	Yes	Yes	1	4	5
119	R:R:F170	R:R:L214	19.5967	8.53	Yes	No	0	6	5
120	R:R:L127	R:R:N352	22.0446	9.61	Yes	No	6	9	9
121	R:R:Q218	R:R:Y247	12.515	10.15	No	Yes	1	5	6
122	L:L:M14	R:R:H248	24.4004	3.94	Yes	Yes	1	0	5
123	R:R:F319	R:R:Y315	26.8412	7.22	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F78	R:R:Q77	14.05	0	No	No	5	5	1	1
R:R:K332	R:R:Q77	16.27	4	No	No	1	5	1	1
L:L:D8	R:R:Q77	5.22	4	No	No	0	5	0	1
R:R:F78	R:R:Q335	5.86	0	No	No	5	3	1	2
L:L:F10	R:R:F78	4.29	0	No	No	0	5	0	1
R:R:N138	R:R:N142	4.09	1	No	Yes	7	6	2	1
R:R:F342	R:R:N138	4.83	1	Yes	No	6	7	2	2
R:R:N142	R:R:Q161	9.24	1	Yes	Yes	6	5	1	2
R:R:F342	R:R:N142	4.83	1	Yes	Yes	6	6	2	1
L:L:L13	R:R:N142	5.49	1	Yes	Yes	0	6	0	1
R:R:S149	R:R:Y145	3.82	0	No	Yes	4	4	2	1
R:R:W151	R:R:Y145	14.47	1	Yes	Yes	8	4	2	1
R:R:F234	R:R:Y145	4.13	1	Yes	Yes	4	4	1	1
L:L:L13	R:R:Y145	4.69	1	Yes	Yes	0	4	0	1
R:R:C158	R:R:W151	3.92	1	Yes	Yes	9	8	2	2
R:R:F234	R:R:W151	12.03	1	Yes	Yes	4	8	1	2
R:R:C158	R:R:S222	5.16	1	Yes	Yes	9	5	2	2
R:R:C158	R:R:F234	13.97	1	Yes	Yes	9	4	2	1
R:R:F234	R:R:Q161	4.68	1	Yes	Yes	4	5	1	2
R:R:I166	R:R:N162	4.25	1	Yes	Yes	4	5	1	1
R:R:N162	R:R:S222	4.47	1	Yes	Yes	5	5	1	2
R:R:F234	R:R:N162	15.71	1	Yes	Yes	4	5	1	1
L:L:L13	R:R:N162	8.24	1	Yes	Yes	0	5	0	1
R:R:F170	R:R:I166	3.77	0	Yes	Yes	6	4	2	1
R:R:I166	R:R:Q218	6.86	1	Yes	No	4	5	1	1
L:L:M14	R:R:I166	4.37	1	Yes	Yes	0	4	0	1
R:R:Q218	R:R:Y247	10.15	1	No	Yes	5	6	1	2
L:L:M14	R:R:Q218	12.23	1	Yes	No	0	5	0	1
R:R:F234	R:R:S222	10.57	1	Yes	Yes	4	5	1	2
L:L:D9	R:R:L232	8.14	0	No	No	0	3	0	1
L:L:L13	R:R:F234	19.49	1	Yes	Yes	0	4	0	1
L:L:F11	R:R:V235	9.18	0	Yes	No	0	4	0	1
R:R:H244	R:R:Q236	6.18	0	Yes	No	5	3	2	1
L:L:F11	R:R:Q236	9.37	0	Yes	No	0	3	0	1
R:R:H244	R:R:H248	5.97	0	Yes	Yes	5	5	2	1
R:R:H248	R:R:Y247	7.62	1	Yes	Yes	5	6	1	2
R:R:F319	R:R:H248	9.05	1	Yes	Yes	5	5	1	1
L:L:M14	R:R:H248	3.94	1	Yes	Yes	0	5	0	1
R:R:W312	R:R:Y315	7.72	1	Yes	Yes	8	6	2	1
R:R:A345	R:R:W312	7.78	1	No	Yes	8	8	2	2
R:R:H316	R:R:Y315	7.62	0	No	Yes	7	6	2	1
R:R:F319	R:R:Y315	7.22	1	Yes	Yes	5	6	1	1
R:R:F342	R:R:Y315	4.13	1	Yes	Yes	6	6	2	1
R:R:A345	R:R:Y315	5.34	1	No	Yes	8	6	2	1
L:L:M14	R:R:Y315	7.18	1	Yes	Yes	0	6	0	1
R:R:F319	R:R:Y318	9.28	1	Yes	Yes	5	4	1	2
R:R:T322	R:R:Y318	6.24	0	No	Yes	4	4	2	2
R:R:I334	R:R:Y318	6.04	0	Yes	Yes	3	4	1	2
R:R:Y318	R:R:Y338	11.91	1	Yes	Yes	4	4	2	1
L:L:M14	R:R:F319	9.95	1	Yes	Yes	0	5	0	1
R:R:N329	R:R:T322	7.31	0	No	No	2	4	1	2
L:L:F11	R:R:N329	3.62	0	Yes	No	0	2	0	1
L:L:D9	R:R:R330	9.53	0	No	No	0	1	0	1
L:L:D8	R:R:K332	8.3	4	No	No	0	1	0	1
L:L:F10	R:R:I334	3.77	0	No	Yes	0	3	0	1
R:R:F342	R:R:Y338	13.41	1	Yes	Yes	6	4	2	1
L:L:F10	R:R:Y338	6.19	0	No	Yes	0	4	0	1
R:R:A215	R:R:I166	3.25	0	No	Yes	7	4	2	1
R:R:I334	R:R:V337	3.07	0	Yes	No	3	5	1	2
L:L:G12	R:R:Y338	2.9	0	No	Yes	0	4	0	1
R:R:S341	R:R:Y318	2.54	1	No	Yes	6	4	2	2
R:R:S341	R:R:Y338	2.54	1	No	Yes	6	4	2	1
R:R:I334	R:R:W331	2.35	0	Yes	No	3	1	1	2
R:R:L232	R:R:M227	1.41	0	No	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JBF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	262
Number of Links	304
Number of Hubs	45
Number of Links mediated by Hubs	159
Number of Communities	8
Number of Nodes involved in Communities	57
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	124
Number Of Links MetaPath	123
Number of Shortest Paths	50191
Length Of Smallest Path	3
Average Path Length	12.3432
Length of Longest Path	28
Minimum Path Strength	1.145
Average Path Strength	6.3923
Maximum Path Strength	16.73
Minimum Path Correlation	0.7
Average Path Correlation	0.923646
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	48.4414
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6734
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29371
Sequence	>8JBF_nogp_Chain_R N Q F V Q P S W R I A L W S L A Y G V V V A V A V L G N L I V I W I I L A H K R M R T V T N Y F L V N L A F S D A S M A A F N T L V N F I Y A L H S E W Y F G A N Y C R F Q N F F P I T A V F A S I Y S M T A I A V D R Y M A I I D P L K P R L S A T A T K I V I G S I W I L A F L L A F P Q C L Y S K T K V M P G R T L C F V Q W P E G P K Q H F T Y H I I V I I L V Y C F P L L I M G I T Y T I V G I T L W G E Q L K A K R K V V K M M I I V V M T F A I C W L P Y H I Y F I L T A I Y Q Q L N R W K Y I Q Q V Y L A S F W L A M S S T M Y N P I I Y C C L N K R F R A G F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JBF	A	Peptide	Tachykinin	NK₃	Homo sapiens	Senktide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2024-02-28	doi.org/10.1038/s41421-023-00564-w
	8JBF (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Senktide	-		3	2024-02-28	doi.org/10.1038/s41421-023-00564-w
	8JBG	A	Peptide	Tachykinin	NK₃	Homo sapiens	Neurokinin-B	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBG (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Neurokinin-B	-		2.8	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBH	A	Peptide	Tachykinin	NK₃	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBH (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Substance-P	-		2.9	2024-02-07	doi.org/10.1038/s41421-023-00564-w

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