psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D4	R:R:Q77	9.14	No	Yes	0	0	4
2	L:L:F5	R:R:N329	7.25	No	No	0	0	5
3	L:L:F6	R:R:F78	5.36	Yes	No	2	0	4
4	L:L:F6	R:R:Q335	4.68	Yes	Yes	2	0	3
5	L:L:F6	R:R:Y338	11.35	Yes	Yes	0	0	4
6	L:L:V7	R:R:Y145	10.09	No	No	0	0	5
7	L:L:G8	R:R:Y338	4.35	No	Yes	0	0	4
8	L:L:L9	R:R:N162	6.87	No	Yes	1	0	5
9	L:L:L9	R:R:F234	20.7	No	Yes	1	0	1
10	L:L:M10	R:R:Q218	4.08	Yes	Yes	1	0	4
11	L:L:M10	R:R:H248	3.94	Yes	Yes	1	0	4
12	L:L:M10	R:R:Y315	5.99	Yes	Yes	1	0	6
13	L:L:M10	R:R:F319	6.22	Yes	Yes	1	0	5
14	R:R:N76	R:R:R230	16.87	No	Yes	0	2	3
15	R:R:F78	R:R:Q77	19.91	No	Yes	0	4	4
16	R:R:F78	R:R:Q335	10.54	No	Yes	2	4	3
17	R:R:H148	R:R:V79	5.54	No	No	0	5	3
18	R:R:P81	R:R:Q80	4.74	No	No	0	4	4
19	R:R:Q80	R:R:R84	12.85	No	Yes	0	4	3
20	R:R:I85	R:R:R84	5.01	No	Yes	2	4	3
21	R:R:R84	R:R:W88	10	Yes	Yes	2	3	5
22	R:R:L147	R:R:R84	6.07	No	Yes	2	4	3
23	R:R:Q335	R:R:R84	15.19	Yes	Yes	2	3	3
24	R:R:Q336	R:R:R84	12.85	Yes	Yes	2	1	3
25	R:R:I85	R:R:L147	8.56	No	No	2	4	4
26	R:R:H148	R:R:I85	9.28	No	No	0	5	4
27	R:R:Q336	R:R:W88	6.57	Yes	Yes	2	1	5
28	R:R:L339	R:R:W88	20.5	No	Yes	2	4	5
29	R:R:F143	R:R:S89	5.28	Yes	No	0	7	5
30	R:R:F143	R:R:Y92	22.69	Yes	No	0	7	6
31	R:R:F342	R:R:Y92	5.16	Yes	No	0	5	6
32	R:R:W343	R:R:Y92	12.54	Yes	No	0	5	6
33	R:R:V95	R:R:W343	6.13	No	Yes	0	7	5
34	R:R:M350	R:R:V98	10.65	No	No	0	7	6
35	R:R:D131	R:R:N103	4.04	Yes	No	0	9	9
36	R:R:N103	R:R:P353	6.52	No	No	0	9	9
37	R:R:F367	R:R:I105	25.12	No	No	0	7	6
38	R:R:F129	R:R:I107	11.3	No	No	0	6	7
39	R:R:I110	R:R:N121	5.66	No	No	0	7	8
40	R:R:I110	R:R:L124	5.71	No	No	0	7	8
41	R:R:I110	R:R:V125	7.68	No	No	0	7	6
42	R:R:K114	R:R:M116	8.64	No	No	5	6	7
43	R:R:K114	R:R:R117	6.19	No	No	5	6	7
44	R:R:M116	R:R:R117	7.44	No	No	5	7	7
45	R:R:T118	R:R:T120	6.28	No	No	0	8	8
46	R:R:V119	R:R:Y122	11.36	No	No	0	6	6
47	R:R:R194	R:R:T120	9.06	No	No	0	4	8
48	R:R:T200	R:R:Y122	4.99	No	No	0	7	6
49	R:R:A178	R:R:F123	6.93	No	Yes	0	7	7
50	R:R:D182	R:R:F123	8.36	No	Yes	0	8	7
51	R:R:F123	R:R:I204	5.02	Yes	No	0	7	7
52	R:R:L124	R:R:Y356	8.21	No	Yes	0	8	9
53	R:R:N126	R:R:S175	5.96	No	No	0	9	7
54	R:R:I204	R:R:N126	9.91	No	No	0	7	9
55	R:R:N126	R:R:W208	6.78	No	Yes	0	9	9
56	R:R:D131	R:R:L127	5.43	Yes	No	0	9	9
57	R:R:L127	R:R:S175	6.01	No	No	0	9	7
58	R:R:L127	R:R:N352	4.12	No	No	0	9	9
59	R:R:S130	R:R:S172	6.52	No	No	0	8	9
60	R:R:S130	R:R:W208	6.18	No	Yes	0	8	9
61	R:R:D131	R:R:S172	8.83	Yes	No	0	9	9
62	R:R:D131	R:R:T349	5.78	Yes	Yes	0	9	9
63	R:R:F164	R:R:S133	7.93	Yes	No	0	5	7
64	R:R:M134	R:R:V169	10.65	Yes	No	0	7	7
65	R:R:M134	R:R:S172	6.13	Yes	No	0	7	9
66	R:R:M134	R:R:M346	4.33	Yes	No	0	7	7
67	R:R:M134	R:R:T349	4.52	Yes	Yes	0	7	9
68	R:R:A135	R:R:T349	5.03	No	Yes	0	6	9
69	R:R:F137	R:R:F160	7.5	No	No	3	5	4
70	R:R:F137	R:R:F164	11.79	No	Yes	3	5	5
71	R:R:N138	R:R:N142	9.54	No	No	4	6	6
72	R:R:N138	R:R:P165	6.52	No	No	0	6	6
73	R:R:F342	R:R:N138	4.83	Yes	No	4	5	6
74	R:R:M346	R:R:T139	6.02	No	No	0	7	7
75	R:R:F153	R:R:V141	3.93	Yes	No	0	6	6
76	R:R:Q161	R:R:V141	8.6	No	No	0	5	6
77	R:R:N142	R:R:Q161	6.6	No	No	0	6	5
78	R:R:F342	R:R:N142	7.25	Yes	No	4	5	6
79	R:R:F143	R:R:L147	9.74	Yes	No	0	7	4
80	R:R:W151	R:R:Y145	11.58	Yes	No	0	8	5
81	R:R:R230	R:R:S149	5.27	Yes	No	0	3	4
82	R:R:E150	R:R:T231	8.47	No	No	0	5	5
83	R:R:F153	R:R:W151	15.03	Yes	Yes	3	6	8
84	R:R:W151	R:R:Y157	6.75	Yes	Yes	3	8	6
85	R:R:L232	R:R:W151	4.56	Yes	Yes	0	4	8
86	R:R:F153	R:R:Y157	20.63	Yes	Yes	3	6	6
87	R:R:F160	R:R:Y157	10.32	No	Yes	3	4	6
88	R:R:Q161	R:R:Y157	13.53	No	Yes	0	5	6
89	R:R:C158	R:R:S222	5.16	No	Yes	1	9	4
90	R:R:C158	R:R:F234	12.57	No	Yes	1	9	1
91	R:R:R159	R:R:S222	5.27	No	Yes	0	7	4
92	R:R:F160	R:R:F164	9.65	No	Yes	3	4	5
93	R:R:N162	R:R:Q218	10.56	Yes	Yes	1	5	4
94	R:R:N162	R:R:S222	10.43	Yes	Yes	1	5	4
95	R:R:F234	R:R:N162	13.29	Yes	Yes	1	1	5
96	R:R:N162	R:R:Q236	7.92	Yes	Yes	1	5	5
97	R:R:F163	R:R:F212	10.72	No	No	0	6	4
98	R:R:F163	R:R:F216	6.43	No	No	0	6	4
99	R:R:C219	R:R:F163	8.38	No	No	0	5	6
100	R:R:F164	R:R:P165	4.33	Yes	No	0	5	6
101	R:R:F170	R:R:I166	5.02	Yes	No	0	5	4
102	R:R:T167	R:R:W208	4.85	No	Yes	0	4	9
103	R:R:F212	R:R:T167	19.46	No	No	0	4	4
104	R:R:F170	R:R:L214	12.18	Yes	No	0	5	5
105	R:R:F170	R:R:V251	3.93	Yes	No	0	5	4
106	R:R:F170	R:R:V255	9.18	Yes	No	0	5	5
107	R:R:A171	R:R:W208	7.78	No	Yes	0	7	9
108	R:R:F308	R:R:I173	5.02	Yes	No	1	9	7
109	R:R:I173	R:R:W312	5.87	No	Yes	1	7	8
110	R:R:I207	R:R:Y174	4.84	No	No	0	7	5
111	R:R:M176	R:R:N352	5.61	No	No	0	8	9
112	R:R:P259	R:R:T177	6.99	No	No	0	9	7
113	R:R:I262	R:R:T177	4.56	No	No	0	6	7
114	R:R:I179	R:R:R183	7.52	No	No	0	9	9
115	R:R:A180	R:R:Y267	6.67	No	Yes	0	8	9
116	R:R:D182	R:R:R194	10.72	No	No	0	8	4
117	R:R:R183	R:R:Y267	8.23	No	Yes	0	9	9
118	R:R:R183	R:R:Y356	6.17	No	Yes	0	9	9
119	R:R:I188	R:R:Y184	10.88	No	No	0	6	8
120	R:R:T266	R:R:Y184	8.74	No	No	0	7	8
121	R:R:I269	R:R:Y184	7.25	No	No	0	4	8
122	R:R:I187	R:R:V270	6.14	No	No	0	8	9
123	R:R:I187	R:R:L274	4.28	No	No	0	8	8
124	R:R:I188	R:R:T273	4.56	No	No	0	6	5
125	R:R:D189	R:R:K192	8.3	No	No	0	5	5
126	R:R:K192	R:R:P193	5.02	No	No	0	5	6
127	R:R:L195	R:R:R194	7.29	No	No	0	4	4
128	R:R:L214	R:R:L254	4.15	No	No	0	5	5
129	R:R:F216	R:R:L220	6.09	No	No	0	4	4
130	R:R:Q218	R:R:Q236	17.92	Yes	Yes	1	4	5
131	R:R:Q218	R:R:Y247	7.89	Yes	No	0	4	6
132	R:R:L220	R:R:Y221	7.03	No	No	0	4	5
133	R:R:P238	R:R:Y221	6.95	No	No	0	4	5
134	R:R:F234	R:R:S222	7.93	Yes	Yes	1	1	4
135	R:R:K223	R:R:V235	10.62	No	No	0	4	5
136	R:R:K223	R:R:P238	11.71	No	No	0	4	4
137	R:R:L232	R:R:T224	8.84	Yes	No	0	4	4
138	R:R:L232	R:R:V226	4.47	Yes	No	0	4	2
139	R:R:M227	R:R:R230	6.2	No	Yes	0	2	3
140	R:R:F234	R:R:Q236	5.86	Yes	Yes	1	1	5
141	R:R:Q236	R:R:W237	6.57	Yes	Yes	0	5	7
142	R:R:Q243	R:R:W237	7.67	No	Yes	0	2	7
143	R:R:H244	R:R:W237	21.16	No	Yes	0	4	7
144	R:R:W237	R:R:Y247	11.58	Yes	No	0	7	6
145	R:R:E239	R:R:Q243	12.74	No	No	0	4	2
146	R:R:G240	R:R:P241	4.06	No	No	0	2	2
147	R:R:H244	R:R:H248	10.75	No	Yes	0	4	4
148	R:R:A323	R:R:H244	8.78	No	No	0	4	4
149	R:R:F245	R:R:I249	10.05	Yes	No	0	2	4
150	R:R:F245	R:R:I320	5.02	Yes	No	0	2	5
151	R:R:F245	R:R:I324	10.05	Yes	No	0	2	5
152	R:R:H248	R:R:Y247	4.36	Yes	No	0	4	6
153	R:R:H248	R:R:V251	5.54	Yes	No	0	4	4
154	R:R:F319	R:R:H248	9.05	Yes	Yes	1	5	4
155	R:R:I250	R:R:L254	4.28	No	No	0	4	5
156	R:R:H316	R:R:I252	9.28	No	No	0	7	5
157	R:R:L313	R:R:Y256	11.72	No	No	0	5	8
158	R:R:F308	R:R:L260	7.31	Yes	No	0	9	6
159	R:R:M301	R:R:Y267	13.17	No	Yes	0	8	9
160	R:R:V305	R:R:Y267	5.05	No	Yes	0	8	9
161	R:R:M301	R:R:V270	4.56	No	No	0	8	9
162	R:R:G271	R:R:V298	5.52	No	No	0	5	6
163	R:R:K294	R:R:L274	5.64	No	No	0	7	8
164	R:R:R295	R:R:W275	10	No	No	0	5	4
165	R:R:K294	R:R:Q290	5.42	No	No	0	7	4
166	R:R:L291	R:R:R295	6.07	No	No	0	2	5
167	R:R:K296	R:R:L359	8.46	No	No	0	8	7
168	R:R:I355	R:R:M300	5.83	No	No	0	8	8
169	R:R:L359	R:R:M300	8.48	No	No	0	7	8
170	R:R:T307	R:R:Y351	9.99	No	Yes	0	6	6
171	R:R:F308	R:R:W312	7.02	Yes	Yes	1	9	8
172	R:R:C311	R:R:Y351	4.03	No	Yes	0	8	6
173	R:R:W312	R:R:Y315	9.65	Yes	Yes	1	8	6
174	R:R:I317	R:R:L313	5.71	No	No	0	6	5
175	R:R:H316	R:R:Y315	10.89	No	Yes	0	7	6
176	R:R:F319	R:R:Y315	14.44	Yes	Yes	1	5	6
177	R:R:A345	R:R:Y315	5.34	No	Yes	0	7	6
178	R:R:F319	R:R:Y318	11.35	Yes	Yes	0	5	4
179	R:R:T322	R:R:Y318	8.74	No	Yes	0	4	4
180	R:R:I334	R:R:Y318	7.25	No	Yes	0	4	4
181	R:R:Y318	R:R:Y338	15.89	Yes	Yes	0	4	4
182	R:R:I324	R:R:Y325	8.46	No	No	0	5	1
183	R:R:L328	R:R:Y325	4.69	No	No	0	5	1
184	R:R:R330	R:R:W331	4	No	No	0	4	1
185	R:R:Q335	R:R:Q336	8.96	Yes	Yes	2	3	1
186	R:R:L339	R:R:Q335	7.99	No	Yes	2	4	3
187	R:R:L339	R:R:Q336	3.99	No	Yes	2	4	1
188	R:R:F342	R:R:Y338	19.6	Yes	Yes	0	5	4
189	R:R:F342	R:R:M346	9.95	Yes	No	0	5	7
190	R:R:S347	R:R:Y351	7.63	No	Yes	0	6	6
191	R:R:N352	R:R:Y356	11.63	No	Yes	0	9	9
192	R:R:I355	R:R:Y356	6.04	No	Yes	0	8	9
193	R:R:C357	R:R:F367	5.59	No	No	0	6	7
194	R:R:N360	R:R:R362	4.82	No	No	0	8	6
195	R:R:F363	R:R:N360	7.25	No	No	0	9	8
196	R:R:A112	R:R:W108	3.89	No	No	0	5	5
197	R:R:F123	R:R:T200	3.89	Yes	No	0	7	7
198	R:R:F363	R:R:I109	3.77	No	No	0	9	8
199	R:R:F308	R:R:M263	3.73	Yes	No	0	9	8
200	R:R:S347	R:R:W343	3.71	No	Yes	0	6	5
201	R:R:P314	R:R:S341	3.56	No	No	0	9	6
202	R:R:G102	R:R:I105	3.53	No	No	0	8	6
203	R:R:L210	R:R:Y174	3.52	No	No	0	4	5
204	R:R:Q327	R:R:R330	3.5	No	No	0	1	4
205	L:L:V7	R:R:C233	3.42	No	No	0	0	9
206	R:R:G102	R:R:L101	3.42	No	No	0	8	4
207	R:R:A199	R:R:S196	3.42	No	No	0	4	7
208	R:R:A197	R:R:V119	3.39	No	No	0	1	6
209	R:R:I173	R:R:P259	3.39	No	No	0	7	9
210	R:R:A99	R:R:T349	3.36	No	Yes	0	8	9
211	R:R:A211	R:R:T167	3.36	No	No	0	8	4
212	R:R:L313	R:R:P314	3.28	No	No	0	5	9
213	R:R:A215	R:R:I166	3.25	No	No	0	7	4
214	R:R:T139	R:R:V96	3.17	No	No	0	7	6
215	R:R:H113	R:R:W108	3.17	No	No	0	6	5
216	R:R:C311	R:R:L344	3.17	No	No	0	8	7
217	R:R:A309	R:R:L260	3.15	No	No	0	6	6
218	R:R:A132	R:R:N103	3.13	No	No	0	8	9
219	R:R:I107	R:R:V125	3.07	No	No	0	7	6
220	R:R:I202	R:R:V203	3.07	No	No	0	2	5
221	R:R:M301	R:R:V297	3.04	No	No	0	8	8
222	R:R:L104	R:R:V100	2.98	No	No	0	4	6
223	R:R:L111	R:R:V125	2.98	No	No	0	4	6
224	R:R:L140	R:R:V141	2.98	No	No	0	8	6
225	R:R:L232	R:R:T231	2.95	Yes	No	0	4	5
226	R:R:L274	R:R:T273	2.95	No	No	0	8	5
227	R:R:I105	R:R:I109	2.94	No	No	0	6	8
228	R:R:F216	R:R:P217	2.89	No	No	0	4	7
229	R:R:K225	R:R:M227	2.88	No	No	0	3	2
230	R:R:I317	R:R:L321	2.85	No	No	0	6	4
231	R:R:I334	R:R:L328	2.85	No	No	0	4	5
232	L:L:F5	R:R:C233	2.79	No	No	0	0	9
233	L:L:F6	R:R:A146	2.77	Yes	No	0	0	4
234	R:R:K332	R:R:Q77	2.71	No	Yes	0	3	4
235	R:R:F123	R:R:V203	2.62	Yes	No	0	7	5
236	R:R:A91	R:R:W343	2.59	No	Yes	0	5	5
237	R:R:V255	R:R:Y174	2.52	No	No	0	5	5
238	R:R:F143	R:R:I144	2.51	Yes	No	0	7	4
239	R:R:F258	R:R:I262	2.51	No	No	0	5	6
240	R:R:K361	R:R:R364	2.48	No	No	0	4	8
241	R:R:S348	R:R:W312	2.47	No	Yes	0	9	8
242	R:R:F363	R:R:L124	2.44	No	No	0	9	8
243	R:R:F258	R:R:L261	2.44	No	No	0	5	4
244	R:R:I252	R:R:Y256	2.42	No	No	0	5	8
245	R:R:M350	R:R:Y351	2.39	No	Yes	0	7	6
246	R:R:Q77	R:R:R330	2.34	Yes	No	0	4	4
247	R:R:E150	R:R:R230	2.33	No	Yes	0	5	3
248	R:R:K299	R:R:W275	2.32	No	No	0	6	4
249	R:R:Q336	R:R:Y333	2.25	Yes	No	0	1	3
250	R:R:A365	R:R:G366	1.95	No	No	0	4	5
251	R:R:G93	R:R:V96	1.84	No	No	0	4	6
252	R:R:G264	R:R:V305	1.84	No	No	0	6	8
253	R:R:G271	R:R:V270	1.84	No	No	0	5	9
254	R:R:P353	R:R:V106	1.77	No	No	0	9	9
255	R:R:G366	R:R:I109	1.76	No	No	0	5	8
256	R:R:G205	R:R:I204	1.76	No	No	0	5	7
257	R:R:A168	R:R:S130	1.71	No	No	0	7	8
258	R:R:A168	R:R:S133	1.71	No	No	0	7	7
259	R:R:A128	R:R:V106	1.7	No	No	0	9	9
260	R:R:A155	R:R:T224	1.68	No	No	0	3	4
261	R:R:M227	R:R:P228	1.68	No	No	0	2	4
262	R:R:E239	R:R:G240	1.64	No	No	0	4	2
263	R:R:D189	R:R:P190	1.61	No	No	0	5	8
264	R:R:V94	R:R:V98	1.6	No	No	0	6	6
265	R:R:V100	R:R:V96	1.6	No	No	0	6	6
266	R:R:A199	R:R:L195	1.58	No	No	0	4	4
267	R:R:I262	R:R:V181	1.54	No	No	0	6	6
268	R:R:I202	R:R:T198	1.52	No	No	0	2	5
269	R:R:M263	R:R:V304	1.52	No	No	0	8	8
270	R:R:I269	R:R:T268	1.52	No	No	0	4	4
271	R:R:M300	R:R:V304	1.52	No	No	0	8	8
272	R:R:F153	R:R:G154	1.51	Yes	No	0	6	8
273	R:R:I252	R:R:I253	1.47	No	No	0	5	5
274	R:R:I265	R:R:I269	1.47	No	No	0	3	4
275	R:R:I302	R:R:M306	1.46	No	No	0	5	5
276	R:R:I310	R:R:M306	1.46	No	No	0	6	5
277	R:R:L195	R:R:M185	1.41	No	No	0	4	5
278	R:R:D189	R:R:I188	1.4	No	No	0	5	6
279	R:R:A136	R:R:F137	1.39	No	No	0	5	5
280	R:R:E239	R:R:K242	1.35	No	No	0	4	1
281	R:R:C257	R:R:Y256	1.34	No	No	0	5	8
282	R:R:L291	R:R:Q290	1.33	No	No	0	2	4
283	R:R:A340	R:R:W88	1.3	No	Yes	0	3	5
284	R:R:F245	R:R:T246	1.3	Yes	No	0	2	4
285	R:R:K368	R:R:R364	1.24	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F6	6.04	4	2	0
2	L:L:M10	5.0575	4	1	0
3	R:R:Q77	8.525	4	0	4
4	R:R:R84	10.3283	6	2	3
5	R:R:W88	9.5925	4	2	5
6	R:R:F123	5.364	5	0	7
7	R:R:D131	6.02	4	0	9
8	R:R:M134	6.4075	4	0	7
9	R:R:F143	10.055	4	0	7
10	R:R:W151	9.48	4	3	8
11	R:R:F153	10.275	4	3	6
12	R:R:Y157	12.8075	4	3	6
13	R:R:N162	9.814	5	1	5
14	R:R:F164	8.425	4	3	5
15	R:R:F170	7.5775	4	0	5
16	R:R:W208	6.3975	4	0	9
17	R:R:Q218	10.1125	4	1	4
18	R:R:S222	7.1975	4	1	4
19	R:R:R230	7.6675	4	0	3
20	R:R:L232	5.205	4	0	4
21	R:R:F234	12.07	5	1	1
22	R:R:Q236	9.5675	4	1	5
23	R:R:W237	11.745	4	0	7
24	R:R:F245	6.605	4	0	2
25	R:R:H248	6.728	5	1	4
26	R:R:Y267	8.28	4	0	9
27	R:R:F308	5.77	4	1	9
28	R:R:W312	6.2525	4	1	8
29	R:R:Y315	9.262	5	1	6
30	R:R:Y318	10.8075	4	0	4
31	R:R:F319	10.265	4	1	5
32	R:R:Q335	9.472	5	2	3
33	R:R:Q336	6.924	5	2	1
34	R:R:Y338	12.7975	4	0	4
35	R:R:F342	9.358	5	4	5
36	R:R:W343	6.2425	4	0	5
37	R:R:T349	4.6725	4	0	9
38	R:R:Y351	6.01	4	0	6
39	R:R:Y356	8.0125	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F78	R:R:Q77	10.8893	19.91	No	Yes	0	4	4
2	L:L:F6	R:R:F78	11.8762	5.36	Yes	No	2	0	4
3	L:L:F6	R:R:Y338	37.2526	11.35	Yes	Yes	0	0	4
4	R:R:F342	R:R:Y338	81.5316	19.6	Yes	Yes	0	5	4
5	R:R:F342	R:R:N142	40.856	7.25	Yes	No	4	5	6
6	R:R:N142	R:R:Q161	39.6436	6.6	No	No	0	6	5
7	R:R:Q161	R:R:Y157	32.7074	13.53	No	Yes	0	5	6
8	R:R:W151	R:R:Y157	37.4443	6.75	Yes	Yes	3	8	6
9	R:R:W151	R:R:Y145	10.7483	11.58	Yes	No	0	8	5
10	R:R:Y318	R:R:Y338	65.8659	15.89	Yes	Yes	0	4	4
11	R:R:F319	R:R:Y318	58.7549	11.35	Yes	Yes	0	5	4
12	L:L:M10	R:R:F319	10.1844	6.22	Yes	Yes	1	0	5
13	L:L:M10	R:R:Q218	21.023	4.08	Yes	Yes	1	0	4
14	R:R:N162	R:R:Q218	10.0885	10.56	Yes	Yes	1	5	4
15	R:R:F319	R:R:H248	36.4856	9.05	Yes	Yes	1	5	4
16	R:R:F319	R:R:Y315	36.4236	14.44	Yes	Yes	1	5	6
17	R:R:L232	R:R:W151	25.9798	4.56	Yes	Yes	0	4	8
18	R:R:L232	R:R:T231	17.4984	2.95	Yes	No	0	4	5
19	R:R:E150	R:R:T231	15.3499	8.47	No	No	0	5	5
20	R:R:E150	R:R:R230	13.1901	2.33	No	Yes	0	5	3
21	R:R:Q335	R:R:R84	10.5397	15.19	Yes	Yes	2	3	3
22	R:R:F143	R:R:L147	12.051	9.74	Yes	No	0	7	4
23	R:R:F342	R:R:Y92	35.7864	5.16	Yes	No	0	5	6
24	R:R:W343	R:R:Y92	19.771	12.54	Yes	No	0	5	6
25	R:R:S347	R:R:W343	14.4533	3.71	No	Yes	0	6	5
26	R:R:S347	R:R:Y351	12.66	7.63	No	Yes	0	6	6
27	R:R:F342	R:R:M346	99.6278	9.95	Yes	No	0	5	7
28	R:R:M134	R:R:M346	100	4.33	Yes	No	0	7	7
29	R:R:M134	R:R:S172	62.426	6.13	Yes	No	0	7	9
30	R:R:D131	R:R:S172	46.6419	8.83	Yes	No	0	9	9
31	R:R:M134	R:R:T349	38.4368	4.52	Yes	Yes	0	7	9
32	R:R:D131	R:R:T349	37.1342	5.78	Yes	Yes	0	9	9
33	R:R:D131	R:R:N103	12.3724	4.04	Yes	No	0	9	9
34	R:R:D131	R:R:L127	74.3755	5.43	Yes	No	0	9	9
35	R:R:L127	R:R:N352	83.7986	4.12	No	No	0	9	9
36	R:R:N352	R:R:Y356	81.8756	11.63	No	Yes	0	9	9
37	R:R:L124	R:R:Y356	41.8993	8.21	No	Yes	0	8	9
38	R:R:F363	R:R:L124	26.149	2.44	No	No	0	9	8
39	R:R:F363	R:R:I109	19.0605	3.77	No	No	0	9	8
40	R:R:I105	R:R:I109	12.192	2.94	No	No	0	6	8
41	R:R:I110	R:R:L124	14.2728	5.71	No	No	0	7	8
42	R:R:S130	R:R:S172	37.5515	6.52	No	No	0	8	9
43	R:R:S130	R:R:W208	32.2393	6.18	No	Yes	0	8	9
44	R:R:N126	R:R:W208	24.914	6.78	No	Yes	0	9	9
45	R:R:I204	R:R:N126	26.961	9.91	No	No	0	7	9
46	R:R:F123	R:R:I204	24.3162	5.02	Yes	No	0	7	7
47	R:R:D182	R:R:F123	11.8029	8.36	No	Yes	0	8	7
48	R:R:D182	R:R:R194	10.5284	10.72	No	No	0	8	4
49	R:R:L127	R:R:S175	16.0379	6.01	No	No	0	9	7
50	R:R:F164	R:R:S133	17.5605	7.93	Yes	No	0	5	7
51	R:R:F160	R:R:F164	14.5322	9.65	No	Yes	3	4	5
52	R:R:F160	R:R:Y157	14.3179	10.32	No	Yes	3	4	6
53	R:R:T167	R:R:W208	18.4007	4.85	No	Yes	0	4	9
54	R:R:F212	R:R:T167	15.4458	19.46	No	No	0	4	4
55	R:R:F163	R:R:F212	13.9514	10.72	No	No	0	6	4
56	R:R:F163	R:R:F216	10.9288	6.43	No	No	0	6	4
57	R:R:H248	R:R:V251	22.6752	5.54	Yes	No	0	4	4
58	R:R:F170	R:R:V251	20.662	3.93	Yes	No	0	5	4
59	R:R:W312	R:R:Y315	48.8411	9.65	Yes	Yes	1	8	6
60	R:R:F308	R:R:W312	38.9895	7.02	Yes	Yes	1	9	8
61	R:R:I173	R:R:P259	10.6863	3.39	No	No	0	7	9
62	R:R:R183	R:R:Y356	67.9242	6.17	No	Yes	0	9	9
63	R:R:R183	R:R:Y267	63.9316	8.23	No	Yes	0	9	9
64	R:R:M301	R:R:Y267	55.7435	13.17	No	Yes	0	8	9
65	R:R:M301	R:R:V270	51.5874	4.56	No	No	0	8	9
66	R:R:I187	R:R:V270	44.8711	6.14	No	No	0	8	9
67	R:R:I187	R:R:L274	42.6155	4.28	No	No	0	8	8
68	R:R:L274	R:R:T273	26.4761	2.95	No	No	0	8	5
69	R:R:I188	R:R:T273	24.1245	4.56	No	No	0	6	5
70	R:R:I188	R:R:Y184	12.2032	10.88	No	No	0	6	8
71	R:R:H248	R:R:Y247	13.9739	4.36	Yes	No	0	4	6
72	R:R:H244	R:R:H248	15.3443	10.75	No	Yes	0	4	4
73	R:R:H244	R:R:W237	11.7465	21.16	No	Yes	0	4	7
74	R:R:W237	R:R:Y247	14.2108	11.58	Yes	No	0	7	6
75	R:R:Q243	R:R:W237	23.961	7.67	No	Yes	0	2	7
76	R:R:E239	R:R:Q243	19.1902	12.74	No	No	0	4	2
77	R:R:I334	R:R:Y318	16.5172	7.25	No	Yes	0	4	4
78	R:R:I334	R:R:L328	14.5604	2.85	No	No	0	4	5
79	R:R:L328	R:R:Y325	12.5134	4.69	No	No	0	5	1
80	R:R:I324	R:R:Y325	10.4551	8.46	No	No	0	5	1
81	R:R:H316	R:R:Y315	17.3631	10.89	No	Yes	0	7	6
82	R:R:H316	R:R:I252	15.677	9.28	No	No	0	7	5
83	R:R:I252	R:R:Y256	12.2709	2.42	No	No	0	5	8
84	R:R:K294	R:R:L274	14.6112	5.64	No	No	0	7	8
85	R:R:K294	R:R:Q290	12.2032	5.42	No	No	0	7	4
86	R:R:F308	R:R:M263	41.3015	3.73	Yes	No	0	9	8
87	R:R:M263	R:R:V304	40.8278	1.52	No	No	0	8	8
88	R:R:M300	R:R:V304	40.4049	1.52	No	No	0	8	8
89	R:R:I355	R:R:M300	41.1267	5.83	No	No	0	8	8
90	R:R:I355	R:R:Y356	42.0967	6.04	No	Yes	0	8	9
91	R:R:A168	R:R:S133	17.2954	1.71	No	No	0	7	7
92	R:R:A168	R:R:S130	17.7691	1.71	No	No	0	7	8
93	L:L:F6	R:R:Q335	22.6527	4.68	Yes	Yes	2	0	3
94	R:R:F143	R:R:Y92	16.6526	22.69	Yes	No	0	7	6
95	R:R:N126	R:R:S175	14.4758	5.96	No	No	0	9	7
96	L:L:M10	R:R:Y315	23.5098	5.99	Yes	Yes	1	0	6
97	L:L:M10	R:R:H248	13.1281	3.94	Yes	Yes	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:D4	R:R:Q77	9.14	0	No	Yes	0	4	0	1
L:L:F5	R:R:N329	7.25	0	No	No	0	5	0	1
L:L:F6	R:R:F78	5.36	2	Yes	No	0	4	0	1
L:L:F6	R:R:Q335	4.68	2	Yes	Yes	0	3	0	1
L:L:F6	R:R:Y338	11.35	2	Yes	Yes	0	4	0	1
L:L:V7	R:R:Y145	10.09	0	No	No	0	5	0	1
L:L:G8	R:R:Y338	4.35	0	No	Yes	0	4	0	1
L:L:L9	R:R:N162	6.87	1	No	Yes	0	5	0	1
L:L:L9	R:R:F234	20.7	1	No	Yes	0	1	0	1
L:L:M10	R:R:Q218	4.08	1	Yes	Yes	0	4	0	1
L:L:M10	R:R:H248	3.94	1	Yes	Yes	0	4	0	1
L:L:M10	R:R:Y315	5.99	1	Yes	Yes	0	6	0	1
L:L:M10	R:R:F319	6.22	1	Yes	Yes	0	5	0	1
R:R:F78	R:R:Q77	19.91	2	No	Yes	4	4	1	1
R:R:F78	R:R:Q335	10.54	2	No	Yes	4	3	1	1
R:R:Q335	R:R:R84	15.19	2	Yes	Yes	3	3	1	2
R:R:Q336	R:R:R84	12.85	2	Yes	Yes	1	3	2	2
R:R:W151	R:R:Y145	11.58	3	Yes	No	8	5	2	1
R:R:C158	R:R:S222	5.16	1	No	Yes	9	4	2	2
R:R:C158	R:R:F234	12.57	1	No	Yes	9	1	2	1
R:R:N162	R:R:Q218	10.56	1	Yes	Yes	5	4	1	1
R:R:N162	R:R:S222	10.43	1	Yes	Yes	5	4	1	2
R:R:F234	R:R:N162	13.29	1	Yes	Yes	1	5	1	1
R:R:N162	R:R:Q236	7.92	1	Yes	Yes	5	5	1	2
R:R:Q218	R:R:Q236	17.92	1	Yes	Yes	4	5	1	2
R:R:Q218	R:R:Y247	7.89	1	Yes	No	4	6	1	2
R:R:F234	R:R:S222	7.93	1	Yes	Yes	1	4	1	2
R:R:F234	R:R:Q236	5.86	1	Yes	Yes	1	5	1	2
R:R:H244	R:R:H248	10.75	0	No	Yes	4	4	2	1
R:R:H248	R:R:Y247	4.36	1	Yes	No	4	6	1	2
R:R:H248	R:R:V251	5.54	1	Yes	No	4	4	1	2
R:R:F319	R:R:H248	9.05	1	Yes	Yes	5	4	1	1
R:R:W312	R:R:Y315	9.65	1	Yes	Yes	8	6	2	1
R:R:H316	R:R:Y315	10.89	0	No	Yes	7	6	2	1
R:R:F319	R:R:Y315	14.44	1	Yes	Yes	5	6	1	1
R:R:A345	R:R:Y315	5.34	0	No	Yes	7	6	2	1
R:R:F319	R:R:Y318	11.35	1	Yes	Yes	5	4	1	2
R:R:Y318	R:R:Y338	15.89	0	Yes	Yes	4	4	2	1
R:R:Q335	R:R:Q336	8.96	2	Yes	Yes	3	1	1	2
R:R:L339	R:R:Q335	7.99	2	No	Yes	4	3	2	1
R:R:L339	R:R:Q336	3.99	2	No	Yes	4	1	2	2
R:R:F342	R:R:Y338	19.6	4	Yes	Yes	5	4	2	1
L:L:V7	R:R:C233	3.42	0	No	No	0	9	0	1
L:L:F5	R:R:C233	2.79	0	No	No	0	9	0	1
L:L:F6	R:R:A146	2.77	2	Yes	No	0	4	0	1
R:R:K332	R:R:Q77	2.71	0	No	Yes	3	4	2	1
R:R:Q77	R:R:R330	2.34	0	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JBG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	262
Number of Links	285
Number of Hubs	39
Number of Links mediated by Hubs	134
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	47122
Length Of Smallest Path	3
Average Path Length	14.0989
Length of Longest Path	30
Minimum Path Strength	1.46
Average Path Strength	7.61919
Maximum Path Strength	17.615
Minimum Path Correlation	0.7
Average Path Correlation	0.918702
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	43.543
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7923
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29371
Sequence	>8JBG_nogp_Chain_R N Q F V Q P S W R I A L W S L A Y G V V V A V A V L G N L I V I W I I L A H K M R T V T N Y F L V N L A F S D A S M A A F N T L V N F I Y A L H S E W Y F G A N Y C R F Q N F F P I T A V F A S I Y S M T A I A V D R Y M A I I D P L K P R L S A T A T K I V I G S I W I L A F L L A F P Q C L Y S K T K V M P G R T L C F V Q W P E G P K Q H F T Y H I I V I I L V Y C F P L L I M G I T Y T I V G I T L W Q L K A K R K V V K M M I I V V M T F A I C W L P Y H I Y F I L T A I Y Q Q L N R W K Y I Q Q V Y L A S F W L A M S S T M Y N P I I Y C C L N K R F R A G F K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JBF	A	Peptide	Tachykinin	NK₃	Homo sapiens	Senktide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2024-02-28	doi.org/10.1038/s41421-023-00564-w
	8JBF (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Senktide	-		3	2024-02-28	doi.org/10.1038/s41421-023-00564-w
	8JBG	A	Peptide	Tachykinin	NK₃	Homo sapiens	Neurokinin-B	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBG (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Neurokinin-B	-		2.8	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBH	A	Peptide	Tachykinin	NK₃	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBH (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Substance-P	-		2.9	2024-02-07	doi.org/10.1038/s41421-023-00564-w

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