psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q5	R:R:K332	13.56	No	No	0	0	3
2	L:L:Q6	R:R:R330	14.02	No	No	0	0	4
3	L:L:F7	L:L:G9	4.52	Yes	No	1	0	0
4	L:L:F7	R:R:S149	3.96	Yes	No	0	0	4
5	L:L:F7	R:R:I334	3.77	Yes	Yes	0	0	4
6	L:L:F7	R:R:Q335	12.88	Yes	No	1	0	3
7	L:L:F7	R:R:Y338	10.32	Yes	Yes	1	0	4
8	L:L:F8	R:R:Q236	7.03	No	Yes	3	0	5
9	L:L:F8	R:R:H244	4.53	No	Yes	3	0	4
10	L:L:G9	R:R:Y338	10.14	No	Yes	1	0	4
11	L:L:L10	R:R:N142	5.49	Yes	Yes	1	0	6
12	L:L:L10	R:R:Y145	4.69	Yes	Yes	1	0	5
13	L:L:L10	R:R:Q161	3.99	Yes	Yes	1	0	5
14	L:L:L10	R:R:N162	9.61	Yes	No	1	0	5
15	L:L:L10	R:R:F234	24.36	Yes	Yes	1	0	1
16	L:L:M11	R:R:I166	5.83	Yes	No	0	0	4
17	L:L:M11	R:R:Q218	9.52	Yes	No	0	0	4
18	L:L:M11	R:R:Y315	7.18	Yes	Yes	1	0	6
19	L:L:M11	R:R:F319	8.71	Yes	Yes	1	0	5
20	R:R:H148	R:R:V79	6.92	Yes	No	0	5	3
21	R:R:P81	R:R:Q80	7.9	No	No	0	4	4
22	R:R:Q335	R:R:Q80	12.8	No	No	1	3	4
23	R:R:Q336	R:R:Q80	8.96	Yes	No	1	1	4
24	R:R:R84	R:R:W88	18.99	No	Yes	1	3	5
25	R:R:Q336	R:R:R84	5.84	Yes	No	1	1	3
26	R:R:I85	R:R:L147	8.56	No	No	1	4	4
27	R:R:H148	R:R:I85	3.98	Yes	No	1	5	4
28	R:R:Q336	R:R:W88	5.48	Yes	Yes	1	1	5
29	R:R:L339	R:R:W88	19.36	No	Yes	1	4	5
30	R:R:A91	R:R:W343	3.89	No	Yes	0	5	5
31	R:R:F143	R:R:Y92	30.95	Yes	Yes	1	7	6
32	R:R:L339	R:R:Y92	3.52	No	Yes	1	4	6
33	R:R:F342	R:R:Y92	7.22	Yes	Yes	1	5	6
34	R:R:W343	R:R:Y92	6.75	Yes	Yes	0	5	6
35	R:R:V95	R:R:W343	7.36	No	Yes	0	7	5
36	R:R:M350	R:R:V95	7.61	No	No	0	7	7
37	R:R:M350	R:R:V98	7.61	No	No	0	7	6
38	R:R:G102	R:R:P353	4.06	No	No	0	8	9
39	R:R:D131	R:R:N103	6.73	Yes	No	0	9	9
40	R:R:F367	R:R:I105	13.82	No	No	0	7	6
41	R:R:F363	R:R:V106	5.24	Yes	No	0	9	9
42	R:R:I107	R:R:V125	4.61	No	No	0	7	6
43	R:R:I109	R:R:W108	3.52	Yes	No	0	8	5
44	R:R:A112	R:R:W108	3.89	No	No	0	5	5
45	R:R:R369	R:R:W108	5	No	No	0	4	5
46	R:R:F363	R:R:I109	7.54	Yes	Yes	0	9	8
47	R:R:I110	R:R:N121	8.5	No	Yes	0	7	8
48	R:R:I110	R:R:V125	6.14	No	No	0	7	6
49	R:R:F363	R:R:I110	5.02	Yes	No	0	9	7
50	R:R:H113	R:R:R369	4.51	No	No	0	6	4
51	R:R:K114	R:R:R117	16.09	No	No	0	6	7
52	R:R:M116	R:R:R362	3.72	No	No	0	7	6
53	R:R:R117	R:R:Y122	5.14	No	No	0	7	6
54	R:R:N121	R:R:T118	4.39	Yes	No	0	8	8
55	R:R:V119	R:R:Y122	5.05	Yes	No	2	6	6
56	R:R:R194	R:R:V119	6.54	Yes	Yes	2	4	6
57	R:R:A197	R:R:V119	5.09	No	Yes	0	1	6
58	R:R:T200	R:R:V119	4.76	Yes	Yes	2	7	6
59	R:R:N121	R:R:T120	4.39	Yes	No	0	8	8
60	R:R:L124	R:R:N121	6.87	No	Yes	0	8	8
61	R:R:T200	R:R:Y122	3.75	Yes	No	2	7	6
62	R:R:F123	R:R:I179	3.77	Yes	No	0	7	9
63	R:R:D182	R:R:F123	5.97	No	Yes	2	8	7
64	R:R:F123	R:R:R194	7.48	Yes	Yes	2	7	4
65	R:R:F123	R:R:T200	5.19	Yes	Yes	2	7	7
66	R:R:F123	R:R:V203	6.55	Yes	No	0	7	5
67	R:R:L124	R:R:Y356	16.41	No	Yes	0	8	9
68	R:R:N126	R:R:S175	5.96	No	No	0	9	7
69	R:R:I204	R:R:N126	15.58	No	No	0	7	9
70	R:R:N126	R:R:W208	9.04	No	Yes	0	9	9
71	R:R:D131	R:R:L127	5.43	Yes	No	4	9	9
72	R:R:L127	R:R:S175	6.01	No	No	0	9	7
73	R:R:L127	R:R:N352	8.24	No	Yes	4	9	9
74	R:R:F129	R:R:S133	5.28	No	Yes	0	6	7
75	R:R:F129	R:R:W208	5.01	No	Yes	0	6	9
76	R:R:S130	R:R:W208	3.71	No	Yes	0	8	9
77	R:R:D131	R:R:S172	4.42	Yes	No	0	9	9
78	R:R:D131	R:R:T349	8.67	Yes	No	0	9	9
79	R:R:D131	R:R:N352	5.39	Yes	Yes	4	9	9
80	R:R:F137	R:R:S133	3.96	No	Yes	5	5	7
81	R:R:F164	R:R:S133	6.61	Yes	Yes	5	5	7
82	R:R:M134	R:R:V169	6.09	Yes	No	1	7	7
83	R:R:M134	R:R:S172	4.6	Yes	No	0	7	9
84	R:R:M134	R:R:W312	4.65	Yes	Yes	1	7	8
85	R:R:M134	R:R:M346	4.33	Yes	Yes	0	7	7
86	R:R:A135	R:R:T349	5.03	No	No	0	6	9
87	R:R:F137	R:R:F164	9.65	No	Yes	5	5	5
88	R:R:N138	R:R:N142	8.17	No	Yes	1	6	6
89	R:R:N138	R:R:P165	8.15	No	No	0	6	6
90	R:R:F342	R:R:N138	7.25	Yes	No	1	5	6
91	R:R:M346	R:R:T139	10.54	Yes	No	0	7	7
92	R:R:V141	R:R:Y157	3.79	No	Yes	1	6	6
93	R:R:Q161	R:R:V141	14.33	Yes	No	1	5	6
94	R:R:N142	R:R:Q161	9.24	Yes	Yes	1	6	5
95	R:R:N142	R:R:Y338	5.81	Yes	Yes	1	6	4
96	R:R:F342	R:R:N142	9.67	Yes	Yes	1	5	6
97	R:R:F143	R:R:L147	19.49	Yes	No	1	7	4
98	R:R:F143	R:R:L339	4.87	Yes	No	1	7	4
99	R:R:I144	R:R:Y152	3.63	No	No	0	4	4
100	R:R:W151	R:R:Y145	11.58	Yes	Yes	1	8	5
101	R:R:F234	R:R:Y145	6.19	Yes	Yes	1	1	5
102	R:R:H148	R:R:L147	6.43	Yes	No	1	5	4
103	R:R:H148	R:R:Y152	8.71	Yes	No	0	5	4
104	R:R:E150	R:R:Y152	12.35	No	No	0	5	4
105	R:R:E150	R:R:T231	4.23	No	No	0	5	5
106	R:R:F153	R:R:W151	10.02	No	Yes	0	6	8
107	R:R:C158	R:R:W151	5.22	No	Yes	1	9	8
108	R:R:L232	R:R:W151	5.69	No	Yes	0	4	8
109	R:R:F234	R:R:W151	30.07	Yes	Yes	1	1	8
110	R:R:F153	R:R:Y157	15.47	No	Yes	0	6	6
111	R:R:A155	R:R:T224	5.03	No	No	0	3	4
112	R:R:F160	R:R:Y157	13.41	No	Yes	0	4	6
113	R:R:Q161	R:R:Y157	5.64	Yes	Yes	1	5	6
114	R:R:C158	R:R:T224	6.76	No	No	0	9	4
115	R:R:C158	R:R:F234	18.15	No	Yes	1	9	1
116	R:R:F160	R:R:F164	7.5	No	Yes	0	4	5
117	R:R:P165	R:R:Q161	11.05	No	Yes	0	6	5
118	R:R:F234	R:R:Q161	4.68	Yes	Yes	1	1	5
119	R:R:N162	R:R:S222	8.94	No	No	1	5	4
120	R:R:F234	R:R:N162	12.08	Yes	No	1	1	5
121	R:R:F163	R:R:F212	10.72	No	No	0	6	4
122	R:R:C219	R:R:F163	9.78	No	No	0	5	6
123	R:R:F164	R:R:P165	4.33	Yes	No	0	5	6
124	R:R:F170	R:R:I166	5.02	Yes	No	0	5	4
125	R:R:T167	R:R:W208	6.06	No	Yes	0	4	9
126	R:R:F212	R:R:T167	16.86	No	No	0	4	4
127	R:R:F170	R:R:V169	3.93	Yes	No	0	5	7
128	R:R:V169	R:R:W312	3.68	No	Yes	1	7	8
129	R:R:F170	R:R:L214	15.83	Yes	No	0	5	5
130	R:R:F170	R:R:V251	3.93	Yes	No	0	5	4
131	R:R:F170	R:R:V255	6.55	Yes	No	0	5	5
132	R:R:A171	R:R:W208	9.08	No	Yes	0	7	9
133	R:R:I173	R:R:V255	6.14	Yes	No	0	7	5
134	R:R:F308	R:R:I173	6.28	Yes	Yes	1	9	7
135	R:R:I173	R:R:W312	11.74	Yes	Yes	1	7	8
136	R:R:I207	R:R:Y174	4.84	No	No	0	7	5
137	R:R:L210	R:R:Y174	3.52	No	No	0	4	5
138	R:R:L254	R:R:Y174	3.52	No	No	0	5	5
139	R:R:M176	R:R:N352	5.61	No	Yes	0	8	9
140	R:R:I262	R:R:T177	4.56	No	No	0	6	7
141	R:R:I179	R:R:R183	7.52	No	Yes	0	9	9
142	R:R:A180	R:R:Y267	6.67	No	Yes	0	8	9
143	R:R:D182	R:R:R194	16.68	No	Yes	2	8	4
144	R:R:R183	R:R:Y267	6.17	Yes	Yes	0	9	9
145	R:R:M300	R:R:R183	3.72	Yes	Yes	0	8	9
146	R:R:I188	R:R:Y184	20.55	No	Yes	0	6	8
147	R:R:T266	R:R:Y184	11.24	No	Yes	0	7	8
148	R:R:I269	R:R:Y184	10.88	Yes	Yes	0	4	8
149	R:R:I187	R:R:V270	7.68	No	No	0	8	9
150	R:R:D189	R:R:K192	8.3	No	No	0	5	5
151	R:R:L195	R:R:R194	3.64	No	Yes	2	4	4
152	R:R:R194	R:R:T200	10.35	Yes	Yes	2	4	7
153	R:R:L195	R:R:T200	4.42	No	Yes	2	4	7
154	R:R:L214	R:R:L254	4.15	No	No	0	5	5
155	R:R:F216	R:R:L220	7.31	No	No	0	4	4
156	R:R:P217	R:R:Y247	9.74	No	Yes	0	7	6
157	R:R:Q218	R:R:Q236	19.2	No	Yes	0	4	5
158	R:R:Q218	R:R:Y247	10.15	No	Yes	0	4	6
159	R:R:L220	R:R:Y221	7.03	No	No	0	4	5
160	R:R:P238	R:R:Y221	5.56	No	No	0	4	5
161	R:R:F234	R:R:S222	3.96	Yes	No	1	1	4
162	R:R:L232	R:R:T224	5.9	No	No	0	4	4
163	R:R:K225	R:R:M227	10.08	No	No	0	3	2
164	R:R:L232	R:R:V226	8.94	No	No	0	4	2
165	R:R:H244	R:R:Q236	3.71	Yes	Yes	3	4	5
166	R:R:Q326	R:R:W237	7.67	No	No	0	1	7
167	R:R:P238	R:R:Q243	4.74	No	No	0	4	2
168	R:R:E239	R:R:Q243	8.92	No	No	0	4	2
169	R:R:G240	R:R:P241	4.06	No	No	0	2	2
170	R:R:P241	R:R:Q326	12.63	No	No	0	2	1
171	R:R:H244	R:R:H248	10.75	Yes	No	0	4	4
172	R:R:A323	R:R:H244	8.78	No	Yes	0	4	4
173	R:R:F245	R:R:I249	10.05	No	No	0	2	4
174	R:R:F245	R:R:I324	13.82	No	No	0	2	5
175	R:R:H248	R:R:Y247	4.36	No	Yes	0	4	6
176	R:R:V251	R:R:Y247	6.31	No	Yes	0	4	6
177	R:R:F319	R:R:H248	9.05	Yes	No	0	5	4
178	R:R:I252	R:R:Y256	4.84	Yes	Yes	1	5	8
179	R:R:H316	R:R:I252	10.61	No	Yes	1	7	5
180	R:R:I252	R:R:I320	5.89	Yes	No	0	5	5
181	R:R:L260	R:R:Y256	4.69	No	Yes	1	6	8
182	R:R:F308	R:R:Y256	6.19	Yes	Yes	1	9	8
183	R:R:A309	R:R:Y256	4	No	Yes	1	6	8
184	R:R:L313	R:R:Y256	12.89	No	Yes	0	5	8
185	R:R:H316	R:R:Y256	5.44	No	Yes	1	7	8
186	R:R:F308	R:R:L260	6.09	Yes	No	1	9	6
187	R:R:A309	R:R:L260	4.73	No	No	1	6	6
188	R:R:F308	R:R:M263	4.98	Yes	No	0	9	8
189	R:R:G264	R:R:V305	3.68	No	No	0	6	8
190	R:R:T266	R:R:Y267	3.75	No	Yes	0	7	9
191	R:R:M301	R:R:Y267	21.55	Yes	Yes	0	8	9
192	R:R:V305	R:R:Y267	5.05	No	Yes	0	8	9
193	R:R:M301	R:R:V270	6.09	Yes	No	0	8	9
194	R:R:G271	R:R:V298	5.52	No	No	0	5	6
195	R:R:K294	R:R:L274	12.69	No	No	0	7	8
196	R:R:R295	R:R:W275	26.99	No	No	0	5	4
197	R:R:V298	R:R:W275	6.13	No	No	0	6	4
198	R:R:L291	R:R:R295	7.29	No	No	0	2	5
199	R:R:K296	R:R:L359	4.23	No	No	0	8	7
200	R:R:M301	R:R:V297	4.56	Yes	No	0	8	8
201	R:R:M300	R:R:M301	4.33	Yes	Yes	0	8	8
202	R:R:I355	R:R:M300	4.37	No	Yes	0	8	8
203	R:R:L359	R:R:M300	7.07	No	Yes	0	7	8
204	R:R:T307	R:R:Y351	7.49	No	No	0	6	6
205	R:R:F308	R:R:W312	10.02	Yes	Yes	1	9	8
206	R:R:W312	R:R:Y315	10.61	Yes	Yes	1	8	6
207	R:R:A345	R:R:W312	5.19	No	Yes	1	7	8
208	R:R:S348	R:R:W312	4.94	No	Yes	0	9	8
209	R:R:I317	R:R:L313	7.14	No	No	0	6	5
210	R:R:P314	R:R:S341	3.56	No	No	0	9	6
211	R:R:H316	R:R:Y315	7.62	No	Yes	1	7	6
212	R:R:F319	R:R:Y315	16.5	Yes	Yes	1	5	6
213	R:R:A345	R:R:Y315	6.67	No	Yes	1	7	6
214	R:R:M346	R:R:Y315	4.79	Yes	Yes	0	7	6
215	R:R:F319	R:R:Y318	11.35	Yes	Yes	1	5	4
216	R:R:T322	R:R:Y318	6.24	No	Yes	0	4	4
217	R:R:I334	R:R:Y318	7.25	Yes	Yes	0	4	4
218	R:R:Y318	R:R:Y338	14.89	Yes	Yes	1	4	4
219	R:R:F319	R:R:Y338	4.13	Yes	Yes	1	5	4
220	R:R:N329	R:R:T322	7.31	No	No	0	5	4
221	R:R:I324	R:R:Y325	10.88	No	No	0	5	1
222	R:R:Q326	R:R:Q327	3.84	No	No	0	1	1
223	R:R:W331	R:R:Y333	6.75	No	No	0	1	3
224	R:R:V337	R:R:W331	3.68	No	No	0	4	1
225	R:R:Q335	R:R:Q336	5.12	No	Yes	1	3	1
226	R:R:F342	R:R:Y338	16.5	Yes	Yes	1	5	4
227	R:R:F342	R:R:M346	13.68	Yes	Yes	0	5	7
228	R:R:S347	R:R:Y351	8.9	No	No	0	6	6
229	R:R:M350	R:R:Y351	3.59	No	No	0	7	6
230	R:R:N352	R:R:Y356	9.3	Yes	Yes	0	9	9
231	R:R:F363	R:R:Y356	5.16	Yes	Yes	0	9	9
232	R:R:C357	R:R:F367	9.78	No	No	0	6	7
233	R:R:N360	R:R:R362	4.82	No	No	0	8	6
234	R:R:F363	R:R:N360	9.67	Yes	No	0	9	8
235	R:R:P259	R:R:T177	3.5	No	No	0	9	7
236	R:R:L344	R:R:W343	3.42	No	Yes	0	7	5
237	R:R:A128	R:R:V106	3.39	No	No	0	9	9
238	R:R:I173	R:R:P259	3.39	Yes	No	0	7	9
239	R:R:A99	R:R:T349	3.36	No	No	0	8	9
240	R:R:A211	R:R:T167	3.36	No	No	0	8	4
241	R:R:K192	R:R:P193	3.35	No	No	0	5	6
242	R:R:M227	R:R:P228	3.35	No	No	0	2	4
243	R:R:L313	R:R:P314	3.28	No	No	0	5	9
244	R:R:A215	R:R:I166	3.25	No	No	0	7	4
245	R:R:T139	R:R:V96	3.17	No	No	0	7	6
246	R:R:C311	R:R:L344	3.17	No	No	0	8	7
247	R:R:P238	R:R:Q236	3.16	No	Yes	0	4	5
248	R:R:A132	R:R:L104	3.15	No	No	0	8	4
249	R:R:A199	R:R:L195	3.15	No	No	0	4	4
250	R:R:A132	R:R:N103	3.13	No	No	0	8	9
251	R:R:R183	R:R:Y356	3.09	Yes	Yes	0	9	9
252	R:R:M185	R:R:V181	3.04	No	No	0	5	6
253	R:R:K223	R:R:V235	3.04	No	No	0	4	5
254	R:R:M300	R:R:V304	3.04	Yes	No	0	8	8
255	R:R:M306	R:R:V305	3.04	No	No	0	5	8
256	R:R:F367	R:R:G102	3.01	No	No	0	7	8
257	R:R:L104	R:R:V100	2.98	No	No	0	4	6
258	R:R:L111	R:R:V125	2.98	No	No	0	4	6
259	R:R:L274	R:R:V297	2.98	No	No	0	8	8
260	R:R:I105	R:R:I109	2.94	No	Yes	0	6	8
261	R:R:I265	R:R:I269	2.94	No	Yes	0	3	4
262	R:R:K296	R:R:K299	2.87	No	No	0	8	6
263	R:R:I105	R:R:L101	2.85	No	No	0	6	4
264	R:R:I250	R:R:L254	2.85	No	No	0	4	5
265	R:R:I317	R:R:L321	2.85	No	No	0	6	4
266	R:R:D189	R:R:I188	2.8	No	No	0	5	6
267	R:R:K361	R:R:N360	2.8	No	No	0	4	8
268	L:L:F7	R:R:A146	2.77	Yes	No	0	0	4
269	R:R:A178	R:R:F123	2.77	No	Yes	0	7	7
270	R:R:A136	R:R:F137	2.77	No	No	0	5	5
271	L:L:Q6	R:R:N329	2.64	No	No	0	0	5
272	R:R:F143	R:R:S89	2.64	Yes	No	0	7	5
273	R:R:F245	R:R:I320	2.51	No	No	0	2	5
274	R:R:K292	R:R:R295	2.48	No	No	0	5	5
275	R:R:F258	R:R:L261	2.44	No	No	0	5	4
276	R:R:L87	R:R:R84	2.43	No	No	0	5	3
277	R:R:N156	R:R:R159	2.41	No	No	0	1	7
278	R:R:M185	R:R:Y184	2.39	No	Yes	0	5	8
279	R:R:I334	R:R:W331	2.35	Yes	No	0	4	1
280	R:R:G366	R:R:I109	1.76	No	Yes	0	5	8
281	R:R:G205	R:R:I204	1.76	No	No	0	5	7
282	R:R:A168	R:R:S130	1.71	No	No	0	7	8
283	R:R:A168	R:R:S133	1.71	No	Yes	0	7	7
284	R:R:A199	R:R:S196	1.71	No	No	0	4	7
285	R:R:C233	R:R:V235	1.71	No	No	0	9	5
286	R:R:L191	R:R:P190	1.64	No	No	0	6	8
287	R:R:E239	R:R:G240	1.64	No	No	0	4	2
288	R:R:D189	R:R:P190	1.61	No	No	0	5	8
289	R:R:V94	R:R:V95	1.6	No	No	0	6	7
290	R:R:V94	R:R:V98	1.6	No	No	0	6	6
291	R:R:C358	R:R:L359	1.59	No	No	0	6	7
292	R:R:I188	R:R:T273	1.52	No	No	0	6	5
293	R:R:I269	R:R:T268	1.52	Yes	No	0	4	4
294	R:R:I272	R:R:T268	1.52	No	No	0	2	4
295	R:R:I269	R:R:T273	1.52	Yes	No	0	4	5
296	R:R:I303	R:R:T307	1.52	No	No	0	6	6
297	R:R:F153	R:R:G154	1.51	No	No	0	6	8
298	R:R:L90	R:R:S89	1.5	No	No	0	6	5
299	R:R:L274	R:R:V298	1.49	No	No	0	8	6
300	R:R:I249	R:R:I253	1.47	No	No	0	4	5
301	R:R:I252	R:R:I253	1.47	Yes	No	0	5	5
302	R:R:I302	R:R:M306	1.46	No	No	0	5	5
303	R:R:G93	R:R:Y92	1.45	No	Yes	0	4	6
304	R:R:F258	R:R:P259	1.44	No	No	0	5	9
305	R:R:I334	R:R:L328	1.43	Yes	No	0	4	5
306	R:R:Q243	R:R:T246	1.42	No	No	0	2	4
307	R:R:K294	R:R:Q290	1.36	No	No	0	7	4
308	R:R:C233	R:R:Y145	1.34	No	Yes	0	9	5
309	R:R:A340	R:R:W88	1.3	No	Yes	0	3	5
310	R:R:K296	R:R:R364	1.24	No	No	0	8	8
311	R:R:K361	R:R:R364	1.24	No	No	0	4	8
312	R:R:K368	R:R:R364	1.24	No	No	0	6	8
313	R:R:K332	R:R:Y333	1.19	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F7	6.37	6	1	0
2	L:L:L10	9.628	5	1	0
3	L:L:M11	7.81	4	1	0
4	R:R:W88	11.2825	4	1	5
5	R:R:Y92	9.978	5	1	6
6	R:R:I109	3.94	4	0	8
7	R:R:V119	5.36	4	2	6
8	R:R:N121	6.0375	4	0	8
9	R:R:F123	5.28833	6	2	7
10	R:R:D131	6.128	5	4	9
11	R:R:S133	4.39	4	5	7
12	R:R:M134	4.9175	4	1	7
13	R:R:N142	7.676	5	1	6
14	R:R:F143	14.4875	4	1	7
15	R:R:Y145	5.95	4	1	5
16	R:R:H148	6.51	4	1	5
17	R:R:W151	12.516	5	1	8
18	R:R:Y157	9.5775	4	1	6
19	R:R:Q161	8.155	6	1	5
20	R:R:F164	7.0225	4	5	5
21	R:R:F170	7.052	5	0	5
22	R:R:I173	6.8875	4	1	7
23	R:R:R183	5.125	4	0	9
24	R:R:Y184	11.265	4	0	8
25	R:R:R194	8.938	5	2	4
26	R:R:T200	5.694	5	2	7
27	R:R:W208	6.58	5	0	9
28	R:R:F234	14.2129	7	1	1
29	R:R:Q236	8.275	4	3	5
30	R:R:H244	6.9425	4	3	4
31	R:R:Y247	7.64	4	0	6
32	R:R:I252	5.7025	4	1	5
33	R:R:Y256	6.34167	6	1	8
34	R:R:Y267	8.638	5	0	9
35	R:R:I269	4.215	4	0	4
36	R:R:M300	4.506	5	0	8
37	R:R:M301	9.1325	4	0	8
38	R:R:F308	6.712	5	1	9
39	R:R:W312	7.26143	7	1	8
40	R:R:Y315	8.895	6	1	6
41	R:R:Y318	9.9325	4	1	4
42	R:R:F319	9.948	5	1	5
43	R:R:I334	3.7	4	0	4
44	R:R:Q336	6.35	4	1	1
45	R:R:Y338	10.2983	6	1	4
46	R:R:F342	10.864	5	1	5
47	R:R:W343	5.355	4	0	5
48	R:R:M346	8.335	4	0	7
49	R:R:N352	7.135	4	4	9
50	R:R:Y356	8.49	4	0	9
51	R:R:F363	6.526	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I334	R:R:W331	15.1848	2.35	Yes	No	0	4	1
2	R:R:I334	R:R:Y318	14.6676	7.25	Yes	Yes	0	4	4
3	L:L:F7	R:R:Y338	14.8498	10.32	Yes	Yes	1	0	4
4	R:R:Y318	R:R:Y338	10.7594	14.89	Yes	Yes	1	4	4
5	R:R:H244	R:R:H248	10.8651	10.75	Yes	No	0	4	4
6	R:R:F319	R:R:H248	13.7425	9.05	Yes	No	0	5	4
7	R:R:F319	R:R:Y318	14.0739	11.35	Yes	Yes	1	5	4
8	L:L:M11	R:R:Q218	25.4926	9.52	Yes	No	0	0	4
9	R:R:Q218	R:R:Q236	24.3781	19.2	No	Yes	0	4	5
10	L:L:L10	R:R:N142	19.9527	5.49	Yes	Yes	1	0	6
11	R:R:N142	R:R:Y338	20.153	5.81	Yes	Yes	1	6	4
12	R:R:N142	R:R:Q161	19.0603	9.24	Yes	Yes	1	6	5
13	R:R:F234	R:R:Q161	10.031	4.68	Yes	Yes	1	1	5
14	R:R:F319	R:R:Y315	22.0361	16.5	Yes	Yes	1	5	6
15	R:R:F342	R:R:Y338	23.0195	16.5	Yes	Yes	1	5	4
16	R:R:F342	R:R:Y92	34.4054	7.22	Yes	Yes	1	5	6
17	R:R:F143	R:R:Y92	12.7591	30.95	Yes	Yes	1	7	6
18	R:R:W343	R:R:Y92	15.6474	6.75	Yes	Yes	0	5	6
19	R:R:V95	R:R:W343	10.9124	7.36	No	Yes	0	7	5
20	R:R:F342	R:R:M346	59.1258	13.68	Yes	Yes	0	5	7
21	R:R:M134	R:R:M346	67.5323	4.33	Yes	Yes	0	7	7
22	R:R:M134	R:R:S172	100	4.6	Yes	No	0	7	9
23	R:R:D131	R:R:S172	99.6394	4.42	Yes	No	0	9	9
24	R:R:D131	R:R:N352	89.9071	5.39	Yes	Yes	4	9	9
25	R:R:N352	R:R:Y356	96.4742	9.3	Yes	Yes	0	9	9
26	R:R:F363	R:R:Y356	28.5194	5.16	Yes	Yes	0	9	9
27	R:R:F363	R:R:I109	14.919	7.54	Yes	Yes	0	9	8
28	R:R:M346	R:R:Y315	30.9197	4.79	Yes	Yes	0	7	6
29	R:R:W312	R:R:Y315	26.3012	10.61	Yes	Yes	1	8	6
30	R:R:M134	R:R:W312	35.6329	4.65	Yes	Yes	1	7	8
31	R:R:R183	R:R:Y356	76.6928	3.09	Yes	Yes	0	9	9
32	R:R:I179	R:R:R183	23.7115	7.52	No	Yes	0	9	9
33	R:R:F123	R:R:I179	22.6844	3.77	Yes	No	0	7	9
34	R:R:F123	R:R:T200	10.9852	5.19	Yes	Yes	2	7	7
35	R:R:N138	R:R:P165	13.4147	8.15	No	No	0	6	6
36	R:R:F164	R:R:P165	17.1044	4.33	Yes	No	0	5	6
37	R:R:F164	R:R:S133	14.4017	6.61	Yes	Yes	5	5	7
38	R:R:F129	R:R:S133	12.2673	5.28	No	Yes	0	6	7
39	R:R:F129	R:R:W208	11.5753	5.01	No	Yes	0	6	9
40	R:R:N126	R:R:W208	10.9415	9.04	No	Yes	0	9	9
41	R:R:F342	R:R:N138	10.4972	7.25	Yes	No	1	5	6
42	R:R:L127	R:R:S175	13.3855	6.01	No	No	0	9	7
43	R:R:N126	R:R:S175	12.4058	5.96	No	No	0	9	7
44	R:R:F308	R:R:W312	11.6991	10.02	Yes	Yes	1	9	8
45	R:R:R183	R:R:Y267	39.1586	6.17	Yes	Yes	0	9	9
46	R:R:M300	R:R:R183	22.3457	3.72	Yes	Yes	0	8	9
47	R:R:T266	R:R:Y267	19.9272	3.75	No	Yes	0	7	9
48	R:R:T266	R:R:Y184	18.7361	11.24	No	Yes	0	7	8
49	R:R:M301	R:R:Y267	16.1501	21.55	Yes	Yes	0	8	9
50	R:R:M300	R:R:M301	15.3742	4.33	Yes	Yes	0	8	8
51	R:R:P238	R:R:Q236	28.0131	3.16	No	Yes	0	4	5
52	R:R:P238	R:R:Q243	18.7907	4.74	No	No	0	4	2
53	R:R:E239	R:R:Q243	14.1359	8.92	No	No	0	4	2
54	R:R:E239	R:R:G240	11.7975	1.64	No	No	0	4	2
55	R:R:H316	R:R:Y315	17.9057	7.62	No	Yes	1	7	6
56	R:R:H316	R:R:I252	11.5207	10.61	No	Yes	1	7	5
57	R:R:M301	R:R:V297	23.4165	4.56	Yes	No	0	8	8
58	R:R:L274	R:R:V297	21.1073	2.98	No	No	0	8	8
59	R:R:L274	R:R:V298	14.1359	1.49	No	No	0	8	6
60	R:R:F319	R:R:Y338	22.342	4.13	Yes	Yes	1	5	4
61	L:L:M11	R:R:Y315	20.0036	7.18	Yes	Yes	1	0	6
62	R:R:F342	R:R:N142	23.6314	9.67	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q5	R:R:K332	13.56	0	No	No	0	3	0	1
L:L:Q6	R:R:R330	14.02	0	No	No	0	4	0	1
L:L:F7	R:R:S149	3.96	1	Yes	No	0	4	0	1
L:L:F7	R:R:I334	3.77	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:Q335	12.88	1	Yes	No	0	3	0	1
L:L:F7	R:R:Y338	10.32	1	Yes	Yes	0	4	0	1
L:L:F8	R:R:Q236	7.03	3	No	Yes	0	5	0	1
L:L:F8	R:R:H244	4.53	3	No	Yes	0	4	0	1
L:L:G9	R:R:Y338	10.14	1	No	Yes	0	4	0	1
L:L:L10	R:R:N142	5.49	1	Yes	Yes	0	6	0	1
L:L:L10	R:R:Y145	4.69	1	Yes	Yes	0	5	0	1
L:L:L10	R:R:Q161	3.99	1	Yes	Yes	0	5	0	1
L:L:L10	R:R:N162	9.61	1	Yes	No	0	5	0	1
L:L:L10	R:R:F234	24.36	1	Yes	Yes	0	1	0	1
L:L:M11	R:R:I166	5.83	1	Yes	No	0	4	0	1
L:L:M11	R:R:Q218	9.52	1	Yes	No	0	4	0	1
L:L:M11	R:R:Y315	7.18	1	Yes	Yes	0	6	0	1
L:L:M11	R:R:F319	8.71	1	Yes	Yes	0	5	0	1
R:R:Q335	R:R:Q80	12.8	1	No	No	3	4	1	2
R:R:Q336	R:R:Q80	8.96	1	Yes	No	1	4	2	2
R:R:N138	R:R:N142	8.17	1	No	Yes	6	6	2	1
R:R:N138	R:R:P165	8.15	1	No	No	6	6	2	2
R:R:F342	R:R:N138	7.25	1	Yes	No	5	6	2	2
R:R:V141	R:R:Y157	3.79	1	No	Yes	6	6	2	2
R:R:Q161	R:R:V141	14.33	1	Yes	No	5	6	1	2
R:R:N142	R:R:Q161	9.24	1	Yes	Yes	6	5	1	1
R:R:N142	R:R:Y338	5.81	1	Yes	Yes	6	4	1	1
R:R:F342	R:R:N142	9.67	1	Yes	Yes	5	6	2	1
R:R:W151	R:R:Y145	11.58	1	Yes	Yes	8	5	2	1
R:R:F234	R:R:Y145	6.19	1	Yes	Yes	1	5	1	1
R:R:C158	R:R:W151	5.22	1	No	Yes	9	8	2	2
R:R:F234	R:R:W151	30.07	1	Yes	Yes	1	8	1	2
R:R:Q161	R:R:Y157	5.64	1	Yes	Yes	5	6	1	2
R:R:C158	R:R:F234	18.15	1	No	Yes	9	1	2	1
R:R:P165	R:R:Q161	11.05	0	No	Yes	6	5	2	1
R:R:F234	R:R:Q161	4.68	1	Yes	Yes	1	5	1	1
R:R:N162	R:R:S222	8.94	1	No	No	5	4	1	2
R:R:F234	R:R:N162	12.08	1	Yes	No	1	5	1	1
R:R:F170	R:R:I166	5.02	0	Yes	No	5	4	2	1
R:R:Q218	R:R:Q236	19.2	0	No	Yes	4	5	1	1
R:R:Q218	R:R:Y247	10.15	0	No	Yes	4	6	1	2
R:R:F234	R:R:S222	3.96	1	Yes	No	1	4	1	2
R:R:H244	R:R:Q236	3.71	3	Yes	Yes	4	5	1	1
R:R:H244	R:R:H248	10.75	3	Yes	No	4	4	1	2
R:R:A323	R:R:H244	8.78	0	No	Yes	4	4	2	1
R:R:H248	R:R:Y247	4.36	0	No	Yes	4	6	2	2
R:R:F319	R:R:H248	9.05	1	Yes	No	5	4	1	2
R:R:W312	R:R:Y315	10.61	1	Yes	Yes	8	6	2	1
R:R:A345	R:R:W312	5.19	1	No	Yes	7	8	2	2
R:R:H316	R:R:Y315	7.62	1	No	Yes	7	6	2	1
R:R:F319	R:R:Y315	16.5	1	Yes	Yes	5	6	1	1
R:R:A345	R:R:Y315	6.67	1	No	Yes	7	6	2	1
R:R:M346	R:R:Y315	4.79	0	Yes	Yes	7	6	2	1
R:R:F319	R:R:Y318	11.35	1	Yes	Yes	5	4	1	2
R:R:T322	R:R:Y318	6.24	0	No	Yes	4	4	2	2
R:R:I334	R:R:Y318	7.25	0	Yes	Yes	4	4	1	2
R:R:Y318	R:R:Y338	14.89	1	Yes	Yes	4	4	2	1
R:R:F319	R:R:Y338	4.13	1	Yes	Yes	5	4	1	1
R:R:N329	R:R:T322	7.31	0	No	No	5	4	1	2
R:R:W331	R:R:Y333	6.75	0	No	No	1	3	2	2
R:R:Q335	R:R:Q336	5.12	1	No	Yes	3	1	1	2
R:R:F342	R:R:Y338	16.5	1	Yes	Yes	5	4	2	1
R:R:F342	R:R:M346	13.68	1	Yes	Yes	5	7	2	2
R:R:A215	R:R:I166	3.25	0	No	No	7	4	2	1
R:R:P238	R:R:Q236	3.16	0	No	Yes	4	5	2	1
L:L:F7	R:R:A146	2.77	1	Yes	No	0	4	0	1
L:L:Q6	R:R:N329	2.64	0	No	No	0	5	0	1
R:R:I334	R:R:W331	2.35	0	Yes	No	4	1	1	2
R:R:I334	R:R:L328	1.43	0	Yes	No	4	5	1	2
R:R:C233	R:R:Y145	1.34	0	No	Yes	9	5	2	1
R:R:K332	R:R:Y333	1.19	0	No	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JBH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	263
Number of Links	313
Number of Hubs	51
Number of Links mediated by Hubs	184
Number of Communities	5
Number of Nodes involved in Communities	58
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	57457
Length Of Smallest Path	3
Average Path Length	12.2632
Length of Longest Path	26
Minimum Path Strength	1.24
Average Path Strength	7.31949
Maximum Path Strength	27.215
Minimum Path Correlation	0.7
Average Path Correlation	0.921716
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.5663
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	59.2384
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29371
Sequence	>8JBH_nogp_Chain_R V Q P S W R I A L W S L A Y G V V V A V A V L G N L I V I W I I L A H K M R T V T N Y F L V N L A F S D A S M A A F N T L V N F I Y A L H S E W Y F G A N Y C R F Q N F F P I T A V F A S I Y S M T A I A V D R Y M A I I D P L K P R L S A T A T K I V I G S I W I L A F L L A F P Q C L Y S K T K V M P T L C F V Q W P E G P K Q H F T Y H I I V I I L V Y C F P L L I M G I T Y T I V G I T L W Q L K A K R K V V K M M I I V V M T F A I C W L P Y H I Y F I L T A I Y Q Q L N R W K Y I Q Q V Y L A S F W L A M S S T M Y N P I I Y C C L N K R F R A G F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JBF	A	Peptide	Tachykinin	NK₃	Homo sapiens	Senktide	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2024-02-28	doi.org/10.1038/s41421-023-00564-w
	8JBF (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Senktide	-		3	2024-02-28	doi.org/10.1038/s41421-023-00564-w
	8JBG	A	Peptide	Tachykinin	NK₃	Homo sapiens	Neurokinin-B	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.8	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBG (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Neurokinin-B	-		2.8	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBH	A	Peptide	Tachykinin	NK₃	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-02-07	doi.org/10.1038/s41421-023-00564-w
	8JBH (No Gprot)	A	Peptide	Tachykinin	NK₃	Homo sapiens	Substance-P	-		2.9	2024-02-07	doi.org/10.1038/s41421-023-00564-w

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