psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q153	L:L:Y149	7.89	No	Yes	6	6	5
2	L:L:F154	L:L:Y149	8.25	Yes	Yes	6	6	5
3	L:L:Y149	R:R:E269	8.98	Yes	No	0	5	4
4	L:L:Y149	R:R:I272	12.09	Yes	Yes	0	5	2
5	L:L:F150	R:R:Y188	20.63	No	No	0	4	3
6	L:L:P151	R:R:H203	9.15	No	Yes	0	9	4
7	L:L:G152	L:L:S157	3.71	No	Yes	0	9	5
8	L:L:F154	L:L:Q153	25.77	Yes	No	6	6	6
9	L:L:Q153	R:R:L186	9.32	No	No	0	6	3
10	L:L:F154	R:R:F101	15	Yes	No	0	6	4
11	L:L:F154	R:R:Q283	7.03	Yes	No	0	6	3
12	L:L:F156	R:R:A117	5.55	No	No	0	9	6
13	L:L:F156	R:R:Y262	9.28	No	No	0	9	6
14	L:L:S157	R:R:Q118	5.78	Yes	No	0	5	5
15	L:L:S157	R:R:R176	9.22	Yes	Yes	1	5	4
16	L:L:S157	R:R:N189	5.96	Yes	No	1	5	4
17	R:R:H38	R:R:L42	7.71	No	No	0	5	5
18	R:R:P287	R:R:S41	3.56	No	No	0	4	5
19	R:R:L44	R:R:L47	4.15	No	No	0	5	4
20	R:R:Y45	R:R:Y93	9.93	Yes	No	7	8	6
21	R:R:I94	R:R:Y45	3.63	No	Yes	0	6	8
22	R:R:T290	R:R:Y45	8.74	No	Yes	7	6	8
23	R:R:F294	R:R:Y45	5.16	No	Yes	0	7	8
24	R:R:L295	R:R:L47	4.15	No	No	0	5	4
25	R:R:F49	R:R:I53	5.02	No	No	0	7	6
26	R:R:F49	R:R:P91	8.67	No	No	0	7	9
27	R:R:D83	R:R:N56	6.73	Yes	No	0	9	9
28	R:R:N56	R:R:P301	8.15	No	No	0	9	9
29	R:R:F62	R:R:V59	5.24	Yes	No	0	7	8
30	R:R:I60	R:R:I81	4.42	No	No	0	7	5
31	R:R:F84	R:R:I60	5.02	No	No	0	7	7
32	R:R:F65	R:R:W61	4.01	No	No	0	4	4
33	R:R:F62	R:R:K66	9.93	Yes	No	8	7	5
34	R:R:F62	R:R:W67	11.02	Yes	Yes	8	7	6
35	R:R:F311	R:R:F62	7.5	Yes	Yes	0	8	7
36	R:R:T63	R:R:W67	3.64	Yes	Yes	0	7	6
37	R:R:L77	R:R:T63	4.42	No	Yes	0	6	7
38	R:R:K66	R:R:W67	11.6	No	Yes	8	5	6
39	R:R:R314	R:R:W67	11	No	Yes	0	6	6
40	R:R:T70	R:R:T73	7.85	No	No	0	7	8
41	R:R:R149	R:R:V71	11.77	Yes	No	0	7	6
42	R:R:S154	R:R:V71	4.85	No	No	0	7	6
43	R:R:R149	R:R:T72	3.88	Yes	No	0	7	7
44	R:R:F127	R:R:W75	4.01	Yes	Yes	0	7	7
45	R:R:V130	R:R:W75	7.36	No	Yes	0	6	7
46	R:R:I131	R:R:W75	3.52	No	Yes	0	8	7
47	R:R:D134	R:R:W75	5.58	No	Yes	0	8	7
48	R:R:S154	R:R:W75	6.18	No	Yes	0	7	7
49	R:R:V157	R:R:W75	6.13	No	Yes	0	6	7
50	R:R:F76	R:R:I131	7.54	No	No	3	8	8
51	R:R:F76	R:R:Y304	5.16	No	Yes	3	8	9
52	R:R:L77	R:R:N78	4.12	No	No	0	6	9
53	R:R:I81	R:R:L77	4.28	No	No	0	5	6
54	R:R:F127	R:R:N78	14.5	Yes	No	0	7	9
55	R:R:I158	R:R:N78	9.91	No	No	0	7	9
56	R:R:D83	R:R:L79	5.43	Yes	No	0	9	9
57	R:R:L128	R:R:L79	4.15	No	No	0	9	9
58	R:R:D83	R:R:S124	4.42	Yes	No	0	9	9
59	R:R:D83	R:R:S297	4.42	Yes	No	0	9	8
60	R:R:D83	R:R:N300	4.04	Yes	Yes	0	9	9
61	R:R:F84	R:R:L88	9.74	No	No	0	7	5
62	R:R:I85	R:R:N120	8.5	No	No	0	6	8
63	R:R:F86	R:R:N120	6.04	No	No	0	7	8
64	R:R:F294	R:R:F86	10.72	No	No	0	7	7
65	R:R:F86	R:R:S297	5.28	No	No	0	7	8
66	R:R:F89	R:R:T116	10.38	No	No	0	6	5
67	R:R:F294	R:R:L90	12.18	No	No	0	7	7
68	R:R:L92	R:R:W103	5.69	No	Yes	1	6	9
69	R:R:F105	R:R:L92	8.53	Yes	No	1	7	6
70	R:R:L109	R:R:L92	8.3	No	No	1	5	6
71	R:R:T290	R:R:Y93	7.49	No	No	7	6	6
72	R:R:W103	R:R:Y96	6.75	Yes	No	0	9	6
73	R:R:F101	R:R:V97	5.24	No	No	0	4	5
74	R:R:H102	R:R:M99	3.94	Yes	No	0	5	4
75	R:R:H184	R:R:N100	7.65	Yes	No	0	3	3
76	R:R:H102	R:R:P104	10.68	Yes	No	0	5	3
77	R:R:H102	R:R:H184	8.36	Yes	Yes	0	5	3
78	R:R:H102	R:R:T185	4.11	Yes	No	0	5	4
79	R:R:F105	R:R:W103	9.02	Yes	Yes	1	7	9
80	R:R:C110	R:R:W103	9.14	No	Yes	1	9	9
81	R:R:C187	R:R:W103	3.92	Yes	Yes	1	9	9
82	R:R:F105	R:R:P104	5.78	Yes	No	0	7	3
83	R:R:F105	R:R:L109	6.09	Yes	No	1	7	5
84	R:R:I107	R:R:T178	4.56	No	No	0	4	5
85	R:R:C110	R:R:C187	7.28	No	Yes	1	9	9
86	R:R:R176	R:R:S114	14.5	Yes	No	0	4	5
87	R:R:F115	R:R:L119	3.65	No	No	0	6	5
88	R:R:F115	R:R:L173	14.61	No	No	0	6	4
89	R:R:A172	R:R:Q118	6.06	No	No	0	4	5
90	R:R:K210	R:R:Q118	4.07	No	No	0	6	5
91	R:R:F122	R:R:M121	3.73	No	No	0	6	7
92	R:R:M121	R:R:W259	8.14	No	Yes	0	7	8
93	R:R:F122	R:R:I168	6.28	No	No	0	6	5
94	R:R:F122	R:R:K210	4.96	No	No	0	6	6
95	R:R:A123	R:R:W162	5.19	No	Yes	0	6	9
96	R:R:P218	R:R:V125	3.53	No	No	0	9	7
97	R:R:F126	R:R:I161	3.77	No	No	0	5	7
98	R:R:F126	R:R:L164	3.65	No	No	0	5	4
99	R:R:F127	R:R:I161	8.79	Yes	No	0	7	7
100	R:R:F127	R:R:W162	4.01	Yes	Yes	0	7	9
101	R:R:L128	R:R:N300	6.87	No	Yes	3	9	9
102	R:R:L128	R:R:Y304	8.21	No	Yes	3	9	9
103	R:R:T129	R:R:T221	4.71	No	No	0	7	6
104	R:R:I131	R:R:Y304	3.63	No	Yes	3	8	9
105	R:R:M222	R:R:S132	6.13	No	No	0	8	9
106	R:R:S132	R:R:Y226	5.09	No	No	0	9	9
107	R:R:D134	R:R:R149	11.91	No	Yes	0	8	7
108	R:R:H135	R:R:L139	10.29	No	No	0	9	8
109	R:R:I140	R:R:Y136	3.63	Yes	No	0	7	7
110	R:R:C228	R:R:Y136	6.72	No	No	0	4	7
111	R:R:H138	R:R:L139	3.86	No	No	0	8	8
112	R:R:H138	R:R:R149	16.93	No	Yes	0	8	7
113	R:R:H141	R:R:I140	5.3	Yes	Yes	0	6	7
114	R:R:I140	R:R:L229	4.28	Yes	No	0	7	7
115	R:R:H141	R:R:L144	7.71	Yes	No	0	6	5
116	R:R:L144	R:R:R147	3.64	No	No	0	5	5
117	R:R:H146	R:R:S145	4.18	No	No	0	5	6
118	R:R:H148	R:R:R147	16.93	No	No	0	3	5
119	R:R:N153	R:R:T150	4.39	No	No	0	4	6
120	R:R:F160	R:R:L164	4.87	No	No	0	3	4
121	R:R:I168	R:R:I213	5.89	No	No	0	5	4
122	R:R:G170	R:R:P171	4.06	No	No	0	4	8
123	R:R:L206	R:R:P171	4.93	No	No	0	5	8
124	R:R:F175	R:R:Y174	13.41	No	No	0	4	5
125	R:R:K193	R:R:Y174	13.14	No	No	0	2	5
126	R:R:F175	R:R:F191	11.79	No	No	2	4	5
127	R:R:F175	R:R:R202	8.55	No	No	2	4	1
128	R:R:C187	R:R:R176	6.96	Yes	Yes	1	9	4
129	R:R:N189	R:R:R176	6.03	No	Yes	1	4	4
130	R:R:D177	R:R:N190	10.77	No	No	0	5	3
131	R:R:C187	R:R:T178	5.07	Yes	No	0	9	5
132	R:R:V179	R:R:Y188	6.31	No	No	0	1	3
133	R:R:F181	R:R:N182	16.92	No	No	0	4	3
134	R:R:N190	R:R:Y188	6.98	No	No	0	3	3
135	R:R:F191	R:R:R202	13.9	No	No	2	5	1
136	R:R:F191	R:R:H203	9.05	No	Yes	2	5	4
137	R:R:D195	R:R:P196	4.83	No	No	0	2	1
138	R:R:D195	R:R:L198	4.07	No	No	0	2	4
139	R:R:D197	R:R:P196	4.83	No	No	0	4	1
140	R:R:D197	R:R:I201	5.6	No	No	0	4	1
141	R:R:L198	R:R:R202	4.86	No	No	0	4	1
142	R:R:L200	R:R:T199	4.42	No	No	0	2	6
143	R:R:H273	R:R:T199	6.85	No	No	0	3	6
144	R:R:H204	R:R:L200	5.14	No	No	0	4	2
145	R:R:H203	R:R:T207	4.11	Yes	No	2	4	5
146	R:R:H203	R:R:L270	7.71	Yes	No	2	4	5
147	R:R:H203	R:R:H273	13.14	Yes	No	0	4	3
148	R:R:H204	R:R:W208	6.35	No	No	0	4	4
149	R:R:H204	R:R:L270	10.29	No	No	0	4	5
150	R:R:L270	R:R:T207	7.37	No	No	2	5	5
151	R:R:F211	R:R:W208	4.01	Yes	No	4	6	4
152	R:R:I267	R:R:W208	7.05	No	No	4	5	4
153	R:R:K210	R:R:Y262	4.78	No	No	0	6	6
154	R:R:F211	R:R:Y215	7.22	Yes	Yes	4	6	8
155	R:R:F211	R:R:H263	5.66	Yes	No	4	6	8
156	R:R:F211	R:R:I267	7.54	Yes	No	4	6	5
157	R:R:G214	R:R:P218	4.06	No	No	0	5	9
158	R:R:L219	R:R:Y215	4.69	No	Yes	0	6	8
159	R:R:T260	R:R:Y215	11.24	No	Yes	0	5	8
160	R:R:H263	R:R:Y215	8.71	No	Yes	4	8	8
161	R:R:F217	R:R:P218	8.67	No	No	0	6	9
162	R:R:F217	R:R:T221	5.19	No	No	0	6	6
163	R:R:F255	R:R:L219	3.65	No	No	0	9	6
164	R:R:F255	R:R:M222	8.71	No	No	0	9	8
165	R:R:I248	R:R:Y226	9.67	No	No	0	7	9
166	R:R:F231	R:R:L227	3.65	No	No	0	3	3
167	R:R:I240	R:R:V233	7.68	No	No	0	5	8
168	R:R:I238	R:R:R236	5.01	No	No	0	4	5
169	R:R:H244	R:R:I240	6.63	No	No	0	7	5
170	R:R:F245	R:R:W246	5.01	No	No	0	6	6
171	R:R:L303	R:R:V250	4.47	No	No	0	8	6
172	R:R:V251	R:R:Y304	16.4	No	Yes	0	7	9
173	R:R:F255	R:R:W259	9.02	No	Yes	0	9	8
174	R:R:C258	R:R:N296	11.02	No	No	0	7	9
175	R:R:A293	R:R:W259	5.19	No	Yes	0	8	8
176	R:R:N296	R:R:W259	7.91	No	Yes	0	9	8
177	R:R:P261	R:R:T260	5.25	No	No	0	9	5
178	R:R:P261	R:R:S289	8.91	No	No	0	9	7
179	R:R:S266	R:R:Y262	7.63	No	No	0	5	6
180	R:R:F265	R:R:W268	5.01	No	No	0	4	4
181	R:R:F265	R:R:M282	3.73	No	No	0	4	4
182	R:R:F265	R:R:G285	6.02	No	No	0	4	6
183	R:R:W268	R:R:Y277	9.65	No	Yes	5	4	1
184	R:R:V281	R:R:W268	3.68	No	No	5	1	4
185	R:R:N275	R:R:T271	4.39	No	No	5	3	4
186	R:R:T271	R:R:Y277	4.99	No	Yes	5	4	1
187	R:R:H273	R:R:I272	3.98	No	Yes	0	3	2
188	R:R:I272	R:R:Y277	3.63	Yes	Yes	0	2	1
189	R:R:N275	R:R:Y277	8.14	No	Yes	5	3	1
190	R:R:S278	R:R:Y277	12.72	No	Yes	0	2	1
191	R:R:V281	R:R:Y277	3.79	No	Yes	5	1	1
192	R:R:H280	R:R:S278	9.76	No	No	0	3	2
193	R:R:A284	R:R:Q283	4.55	No	No	0	2	3
194	R:R:I286	R:R:P287	5.08	No	No	0	4	4
195	R:R:L295	R:R:L299	4.15	No	No	0	5	7
196	R:R:N296	R:R:N300	5.45	No	Yes	0	9	9
197	R:R:L299	R:R:L303	4.15	No	No	0	7	8
198	R:R:N300	R:R:Y304	5.81	Yes	Yes	3	9	9
199	R:R:I302	R:R:L306	4.28	No	No	0	6	6
200	R:R:F311	R:R:L306	15.83	Yes	No	0	8	6
201	R:R:F311	R:R:F315	13.93	Yes	No	0	8	5
202	R:R:F315	R:R:V319	7.87	No	No	0	5	5
203	R:R:G64	R:R:K69	3.49	No	No	0	3	7
204	R:R:C225	R:R:S132	3.44	No	No	0	6	9
205	R:R:G291	R:R:L44	3.42	No	No	0	4	5
206	R:R:L119	R:R:W162	3.42	No	Yes	0	5	9
207	R:R:I53	R:R:P54	3.39	No	No	0	6	4
208	R:R:A80	R:R:V59	3.39	No	No	0	8	8
209	R:R:N113	R:R:W103	3.39	No	Yes	0	5	9
210	R:R:L90	R:R:P91	3.28	No	No	0	7	9
211	R:R:S124	R:R:V125	3.23	No	No	0	9	7
212	R:R:V305	R:R:V59	3.21	No	No	0	6	8
213	R:R:V250	R:R:V253	3.21	No	No	0	6	5
214	R:R:T63	R:R:T73	3.14	Yes	No	0	7	8
215	R:R:T70	R:R:T72	3.14	No	No	0	7	7
216	R:R:I224	R:R:S223	3.1	No	No	0	4	3
217	R:R:F115	R:R:G170	3.01	No	No	0	6	4
218	R:R:I286	R:R:M282	2.92	No	No	0	4	4
219	R:R:I230	R:R:K234	2.91	No	No	0	4	5
220	R:R:G291	R:R:Y45	2.9	No	Yes	0	4	8
221	R:R:K309	R:R:K310	2.87	No	No	0	6	6
222	R:R:I158	R:R:L74	2.85	No	No	0	7	6
223	R:R:I137	R:R:L144	2.85	No	No	0	5	5
224	R:R:I159	R:R:L163	2.85	No	No	0	3	4
225	R:R:I212	R:R:L216	2.85	No	No	0	5	4
226	R:R:H138	R:R:S145	2.79	No	No	0	8	6
227	R:R:L151	R:R:L74	2.77	No	No	0	3	6
228	R:R:H244	R:R:T247	2.74	No	No	0	7	7
229	R:R:C225	R:R:Y136	2.69	No	No	0	6	7
230	R:R:L198	R:R:Q192	2.66	No	No	0	4	4
231	R:R:H279	R:R:I272	2.65	No	Yes	0	1	2
232	R:R:N190	R:R:Q192	2.64	No	No	0	3	4
233	R:R:H141	R:R:K232	2.62	Yes	No	0	6	5
234	R:R:A82	R:R:W162	2.59	No	Yes	0	8	9
235	R:R:H274	R:R:N275	2.55	No	No	0	3	3
236	R:R:V256	R:R:Y215	2.52	No	Yes	0	5	8
237	R:R:V252	R:R:Y226	2.52	No	No	0	7	9
238	R:R:F315	R:R:I58	2.51	No	No	0	5	6
239	R:R:F245	R:R:I230	2.51	No	No	0	6	4
240	R:R:K111	R:R:R176	2.48	No	Yes	0	7	4
241	R:R:K309	R:R:R243	2.48	No	No	0	6	7
242	R:R:S242	R:R:W246	2.47	No	No	0	5	6
243	R:R:V36	R:R:W39	2.45	No	No	0	3	3
244	R:R:K111	R:R:W108	2.32	No	No	0	7	1
245	R:R:G169	R:R:G170	2.11	No	No	0	7	4
246	R:R:G52	R:R:P54	2.03	No	No	0	8	4
247	R:R:F62	R:R:W61	2	Yes	No	0	7	4
248	R:R:C298	R:R:G52	1.96	No	No	0	7	8
249	R:R:G64	R:R:T63	1.82	No	Yes	0	3	7
250	R:R:A123	R:R:A165	1.79	No	No	0	6	8
251	R:R:P142	R:R:V143	1.77	No	No	0	8	5
252	L:L:A155	L:L:S157	1.71	No	Yes	0	9	5
253	R:R:G52	R:R:L87	1.71	No	No	0	8	6
254	R:R:C258	R:R:V257	1.71	No	No	0	7	5
255	R:R:A284	R:R:V37	1.7	No	No	0	2	3
256	R:R:C46	R:R:I94	1.64	No	No	0	5	6
257	R:R:L292	R:R:P261	1.64	No	No	0	7	9
258	R:R:A98	R:R:M99	1.61	No	No	0	4	4
259	R:R:V36	R:R:V40	1.6	No	No	0	3	6
260	R:R:V205	R:R:V209	1.6	No	No	0	3	2
261	R:R:C225	R:R:L133	1.59	No	No	0	6	6
262	R:R:A48	R:R:L87	1.58	No	No	0	6	6
263	R:R:A112	R:R:L109	1.58	No	No	0	4	5
264	R:R:I140	R:R:V233	1.54	Yes	No	0	7	8
265	R:R:H141	R:R:P142	1.53	Yes	No	0	6	8
266	R:R:K310	R:R:S308	1.53	No	No	0	6	8
267	R:R:L288	R:R:S41	1.5	No	No	0	5	5
268	R:R:K68	R:R:T70	1.5	No	No	0	7	7
269	R:R:L119	R:R:S166	1.5	No	No	0	5	4
270	R:R:K152	R:R:T150	1.5	No	No	0	5	6
271	R:R:L167	R:R:S166	1.5	No	No	0	4	4
272	R:R:L42	R:R:V97	1.49	No	No	0	5	5
273	R:R:L47	R:R:V43	1.49	No	No	0	4	5
274	R:R:L51	R:R:V50	1.49	No	No	0	5	4
275	R:R:I158	R:R:I159	1.47	No	No	0	7	3
276	R:R:I230	R:R:I248	1.47	No	No	0	4	7
277	R:R:N120	R:R:T116	1.46	No	No	0	8	5
278	R:R:I159	R:R:L155	1.43	No	No	0	3	4
279	R:R:I156	R:R:N153	1.42	No	No	0	3	4
280	R:R:E180	R:R:T185	1.41	No	No	0	1	4
281	R:R:H244	R:R:S241	1.39	No	No	0	7	7
282	R:R:H279	R:R:S276	1.39	No	No	0	1	3
283	R:R:E321	R:R:I322	1.37	No	No	0	3	5
284	R:R:F105	R:R:S95	1.32	Yes	No	0	7	4
285	R:R:R243	R:R:S241	1.32	No	No	0	7	7
286	R:R:F311	R:R:S308	1.32	Yes	No	0	8	8
287	R:R:H184	R:R:N182	1.28	Yes	No	0	3	3
288	R:R:H184	R:R:N183	1.28	Yes	No	0	3	5
289	R:R:F211	R:R:I212	1.26	Yes	No	0	6	5
290	R:R:F311	R:R:Q312	1.17	Yes	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y149	9.3025	4	6	5
2	L:L:F154	14.0125	4	6	6
3	L:L:S157	5.276	5	1	5
4	R:R:Y45	6.072	5	7	8
5	R:R:F62	7.138	5	8	7
6	R:R:T63	3.255	4	0	7
7	R:R:W67	9.315	4	8	6
8	R:R:W75	5.46333	6	0	7
9	R:R:D83	5.008	5	0	9
10	R:R:H102	6.7725	4	0	5
11	R:R:W103	6.31833	6	1	9
12	R:R:F105	6.148	5	1	7
13	R:R:F127	7.8275	4	0	7
14	R:R:I140	3.6875	4	0	7
15	R:R:H141	4.29	4	0	6
16	R:R:R149	11.1225	4	0	7
17	R:R:W162	3.8025	4	0	9
18	R:R:R176	7.838	5	1	4
19	R:R:H184	4.6425	4	0	3
20	R:R:C187	5.8075	4	1	9
21	R:R:H203	8.632	5	2	4
22	R:R:F211	5.138	5	4	6
23	R:R:Y215	6.876	5	4	8
24	R:R:W259	7.565	4	0	8
25	R:R:I272	5.5875	4	0	2
26	R:R:Y277	7.15333	6	5	1
27	R:R:N300	5.5425	4	3	9
28	R:R:Y304	7.842	5	3	9
29	R:R:F311	7.95	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y149	R:R:I272	27.3647	12.09	Yes	Yes	0	5	2
2	R:R:L198	R:R:R202	13.6526	4.86	No	No	0	4	1
3	R:R:F191	R:R:R202	14.6986	13.9	No	No	2	5	1
4	R:R:F191	R:R:H203	19.4973	9.05	No	Yes	2	5	4
5	R:R:H203	R:R:H273	35.5889	13.14	Yes	No	0	4	3
6	R:R:H273	R:R:I272	66.0024	3.98	No	Yes	0	3	2
7	L:L:S157	R:R:Q118	42.3904	5.78	Yes	No	0	5	5
8	R:R:K210	R:R:Q118	44.5816	4.07	No	No	0	6	5
9	R:R:F122	R:R:K210	50.0099	4.96	No	No	0	6	6
10	R:R:F122	R:R:M121	53.1727	3.73	No	No	0	6	7
11	R:R:M121	R:R:W259	54.2038	8.14	No	Yes	0	7	8
12	R:R:F255	R:R:W259	100	9.02	No	Yes	0	9	8
13	R:R:F255	R:R:L219	95.3252	3.65	No	No	0	9	6
14	R:R:L219	R:R:Y215	94.8295	4.69	No	Yes	0	6	8
15	R:R:F211	R:R:Y215	90.6355	7.22	Yes	Yes	4	6	8
16	R:R:F211	R:R:W208	88.2957	4.01	Yes	No	4	6	4
17	R:R:H204	R:R:W208	88.1073	6.35	No	No	0	4	4
18	R:R:H204	R:R:L200	34.538	5.14	No	No	0	4	2
19	R:R:L200	R:R:T199	33.6407	4.42	No	No	0	2	6
20	R:R:H273	R:R:T199	32.8376	6.85	No	No	0	3	6
21	R:R:H204	R:R:L270	53.1479	10.29	No	No	0	4	5
22	R:R:H203	R:R:L270	51.2889	7.71	Yes	No	2	4	5
23	L:L:S157	R:R:R176	37.909	9.22	Yes	Yes	1	5	4
24	R:R:I272	R:R:Y277	34.2009	3.63	Yes	Yes	0	2	1
25	R:R:W268	R:R:Y277	18.4761	9.65	No	Yes	5	4	1
26	R:R:F265	R:R:W268	16.2354	5.01	No	No	0	4	4
27	R:R:F265	R:R:M282	11.6449	3.73	No	No	0	4	4
28	R:R:N296	R:R:W259	97.1198	7.91	No	Yes	0	9	8
29	R:R:N296	R:R:N300	96.2274	5.45	No	Yes	0	9	9
30	R:R:D83	R:R:N300	50.9518	4.04	Yes	Yes	0	9	9
31	R:R:D83	R:R:S297	39.307	4.42	Yes	No	0	9	8
32	R:R:F86	R:R:S297	38.137	5.28	No	No	0	7	8
33	R:R:F294	R:R:F86	32.1386	10.72	No	No	0	7	7
34	R:R:F294	R:R:Y45	19.3982	5.16	No	Yes	0	7	8
35	R:R:G291	R:R:Y45	12.6562	2.9	No	Yes	0	4	8
36	R:R:G291	R:R:L44	11.278	3.42	No	No	0	4	5
37	R:R:F294	R:R:L90	12.7553	12.18	No	No	0	7	7
38	R:R:L90	R:R:P91	11.3772	3.28	No	No	0	7	9
39	R:R:N300	R:R:Y304	72.2784	5.81	Yes	Yes	3	9	9
40	R:R:I131	R:R:Y304	70.4243	3.63	No	Yes	3	8	9
41	R:R:I131	R:R:W75	70.112	3.52	No	Yes	0	8	7
42	R:R:F127	R:R:W75	55.7109	4.01	Yes	Yes	0	7	7
43	R:R:F127	R:R:N78	38.5039	14.5	Yes	No	0	7	9
44	R:R:L77	R:R:N78	31.1124	4.12	No	No	0	6	9
45	R:R:L77	R:R:T63	26.2046	4.42	No	Yes	0	6	7
46	R:R:T63	R:R:W67	23.0171	3.64	Yes	Yes	0	7	6
47	R:R:F62	R:R:W67	19.6758	11.02	Yes	Yes	8	7	6
48	R:R:F311	R:R:F62	13.6278	7.5	Yes	Yes	0	8	7
49	R:R:D134	R:R:W75	13.3254	5.58	No	Yes	0	8	7
50	R:R:D134	R:R:R149	12.1108	11.91	No	Yes	0	8	7
51	R:R:C187	R:R:R176	33.3532	6.96	Yes	Yes	1	9	4
52	R:R:C187	R:R:W103	28.3115	3.92	Yes	Yes	1	9	9
53	R:R:F105	R:R:W103	20.5929	9.02	Yes	Yes	1	7	9
54	R:R:F105	R:R:P104	15.3728	5.78	Yes	No	0	7	3
55	R:R:H102	R:R:P104	14.0244	10.68	Yes	No	0	5	3
56	R:R:F127	R:R:W162	18.1241	4.01	Yes	Yes	0	7	9
57	R:R:L119	R:R:W162	12.7107	3.42	No	Yes	0	5	9
58	R:R:F255	R:R:M222	36.4119	8.71	No	No	0	9	8
59	R:R:M222	R:R:S132	35.4006	6.13	No	No	0	8	9
60	R:R:S132	R:R:Y226	11.2978	5.09	No	No	0	9	9
61	R:R:C225	R:R:S132	25.9667	3.44	No	No	0	6	9
62	R:R:C225	R:R:Y136	23.7954	2.69	No	No	0	6	7
63	R:R:I140	R:R:Y136	21.6488	3.63	Yes	No	0	7	7
64	R:R:H141	R:R:I140	11.3226	5.3	Yes	Yes	0	6	7
65	R:R:I140	R:R:V233	11.1194	1.54	Yes	No	0	7	8
66	R:R:I240	R:R:V233	10.2072	7.68	No	No	0	5	8
67	L:L:F154	L:L:Y149	18.2629	8.25	Yes	Yes	6	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y149	R:R:E269	8.98	6	Yes	No	5	4	0	1
L:L:Y149	R:R:I272	12.09	6	Yes	Yes	5	2	0	1
L:L:F150	R:R:Y188	20.63	0	No	No	4	3	0	1
L:L:P151	R:R:H203	9.15	0	No	Yes	9	4	0	1
L:L:Q153	R:R:L186	9.32	6	No	No	6	3	0	1
L:L:F154	R:R:F101	15	6	Yes	No	6	4	0	1
L:L:F154	R:R:Q283	7.03	6	Yes	No	6	3	0	1
L:L:F156	R:R:A117	5.55	0	No	No	9	6	0	1
L:L:F156	R:R:Y262	9.28	0	No	No	9	6	0	1
L:L:S157	R:R:Q118	5.78	1	Yes	No	5	5	0	1
L:L:S157	R:R:R176	9.22	1	Yes	Yes	5	4	0	1
L:L:S157	R:R:N189	5.96	1	Yes	No	5	4	0	1
R:R:F101	R:R:V97	5.24	0	No	No	4	5	1	2
R:R:R176	R:R:S114	14.5	1	Yes	No	4	5	1	2
R:R:A172	R:R:Q118	6.06	0	No	No	4	5	2	1
R:R:K210	R:R:Q118	4.07	0	No	No	6	5	2	1
R:R:C187	R:R:R176	6.96	1	Yes	Yes	9	4	2	1
R:R:N189	R:R:R176	6.03	1	No	Yes	4	4	1	1
R:R:V179	R:R:Y188	6.31	0	No	No	1	3	2	1
R:R:N190	R:R:Y188	6.98	0	No	No	3	3	2	1
R:R:F191	R:R:H203	9.05	2	No	Yes	5	4	2	1
R:R:H203	R:R:T207	4.11	2	Yes	No	4	5	1	2
R:R:H203	R:R:L270	7.71	2	Yes	No	4	5	1	2
R:R:H203	R:R:H273	13.14	2	Yes	No	4	3	1	2
R:R:L270	R:R:T207	7.37	2	No	No	5	5	2	2
R:R:K210	R:R:Y262	4.78	0	No	No	6	6	2	1
R:R:S266	R:R:Y262	7.63	0	No	No	5	6	2	1
R:R:H273	R:R:I272	3.98	0	No	Yes	3	2	2	1
R:R:I272	R:R:Y277	3.63	0	Yes	Yes	2	1	1	2
R:R:A284	R:R:Q283	4.55	0	No	No	2	3	2	1
R:R:H279	R:R:I272	2.65	0	No	Yes	1	2	2	1
R:R:K111	R:R:R176	2.48	0	No	Yes	7	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JJP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	279
Number of Links	290
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	8
Number of Nodes involved in Communities	39
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	40650
Length Of Smallest Path	3
Average Path Length	16.6408
Length of Longest Path	34
Minimum Path Strength	1.245
Average Path Strength	5.99588
Maximum Path Strength	20.385
Minimum Path Correlation	0.7
Average Path Correlation	0.934337
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	47.5813
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.6093
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• humoral immune response • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • immune system process • antifungal humoral response • response to external biotic stimulus • response to fungus • developmental process • cellular developmental process • cell differentiation • cellular process • chemotaxis • positive regulation of locomotion • regulation of biological process • regulation of response to external stimulus • biological regulation • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • response to activity • multicellular organismal process • digestive system development • tube development • animal organ development • embryo development • digestive tract development • multicellular organism development • anatomical structure development • embryonic organ development • embryonic digestive tract development • system development • innate immune response • lipid catabolic process • catabolic process • regulation of cellular process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • response to nutrient levels • response to caloric restriction • cellular response to stimulus • regulation of cell motility • macrophage migration • positive regulation of cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • cellular response to nitrogen compound • signaling • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cell communication • cellular response to endogenous stimulus • response to hormone • signal transduction • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • macromolecule metabolic process • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • positive regulation of systemic arterial blood pressure • system process • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • regulation of biological quality • blood circulation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle • organelle lumen • platelet dense granule • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • cell periphery • extracellular matrix • external encapsulating structure • extracellular region • extracellular space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • ciliary basal body • adipokinetic hormone binding • peptide hormone binding • hormone binding • molecular transducer activity • protein-hormone receptor activity • adipokinetic hormone receptor activity • signaling receptor activity • neuropeptide binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Chemerin-9
UniProt	Q99969
Sequence	>8JJP_nogp_Chain_L Y F P G Q F A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>8JJP_nogp_Chain_R G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N F Q K H D P D L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S I L I S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F Q A R F R S S V A E I L K Y T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9UYH	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYH (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYI	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.2	2025-11-19	10.1126/science.adt8794
	9UYI (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.2	2025-11-19	10.1126/science.adt8794
	9UYJ	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYJ (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYL	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYL (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	chim(Arrestin3-CtArrestin2)	3.5	2025-11-19	10.1126/science.adt8794
	9UYM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.5	2025-11-19	10.1126/science.adt8794
	9UYN	A	Protein	Chemerin	CML2	Homo sapiens	-	-	Arrestin2	2.9	2025-11-19	10.1126/science.adt8794
	9UYN (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	-	-		2.9	2025-11-19	10.1126/science.adt8794

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.