psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E24	L:L:T23	2.82	No	No	0	0	0
2	L:L:Q26	L:L:T23	9.92	Yes	No	0	0	0
3	L:L:A25	L:L:I64	3.25	No	No	0	0	0
4	L:L:A55	L:L:Q26	4.55	No	Yes	0	0	0
5	L:L:D57	L:L:Q26	13.05	No	Yes	10	0	0
6	L:L:Q26	L:L:V66	4.3	Yes	Yes	10	0	0
7	L:L:L30	L:L:R27	14.58	No	No	0	0	0
8	L:L:F70	L:L:L30	4.87	No	No	0	0	0
9	L:L:Q31	L:L:V32	4.3	No	No	0	0	0
10	L:L:E35	L:L:Q31	15.29	No	No	0	0	0
11	L:L:A33	L:L:V115	5.09	No	No	0	0	0
12	L:L:L34	L:L:P85	3.28	No	No	0	0	0
13	L:L:E35	L:L:K83	22.95	No	No	0	0	0
14	L:L:E36	L:L:R113	29.08	Yes	Yes	11	0	0
15	L:L:E36	L:L:V115	7.13	Yes	No	0	0	0
16	L:L:E36	R:R:Y21	4.49	Yes	No	0	0	3
17	L:L:E36	R:R:S23	4.31	Yes	No	11	0	5
18	L:L:F37	R:R:L19	4.87	No	No	0	0	3
19	L:L:F37	R:R:Y21	8.25	No	No	0	0	3
20	L:L:A46	L:L:H38	5.85	No	No	0	0	0
21	L:L:H40	L:L:K39	3.93	No	No	0	0	0
22	L:L:P41	R:R:N14	9.77	No	No	0	0	7
23	L:L:W45	R:R:F12	10.02	No	No	0	0	3
24	L:L:W45	R:R:N14	12.43	No	No	0	0	7
25	L:L:F47	L:L:Q48	16.4	Yes	No	0	0	0
26	L:L:F47	L:L:Q73	36.31	Yes	Yes	0	0	0
27	L:L:F47	L:L:S76	5.28	Yes	No	0	0	0
28	L:L:C87	L:L:F47	8.38	No	Yes	0	0	0
29	L:L:P85	L:L:Q48	4.74	No	No	0	0	0
30	L:L:E49	L:L:V52	8.56	No	No	0	0	0
31	L:L:S51	L:L:T50	3.2	No	No	0	0	0
32	L:L:Q73	L:L:T50	2.83	Yes	No	12	0	0
33	L:L:R90	L:L:T50	11.64	No	No	12	0	0
34	L:L:K71	L:L:S51	4.59	No	No	0	0	0
35	L:L:E53	L:L:E69	10.15	No	No	0	0	0
36	L:L:E53	L:L:K97	5.4	No	No	0	0	0
37	L:L:D57	L:L:V66	7.3	No	Yes	10	0	0
38	L:L:F65	L:L:T58	5.19	Yes	No	0	0	0
39	L:L:I64	L:L:P59	3.39	No	No	0	0	0
40	L:L:F60	L:L:P61	4.33	No	No	0	0	0
41	L:L:K103	L:L:P61	6.69	No	No	0	0	0
42	L:L:P61	L:L:Q139	7.9	No	No	0	0	0
43	L:L:A62	L:L:K103	3.21	No	No	0	0	0
44	L:L:C101	L:L:F65	4.19	Yes	Yes	0	0	0
45	L:L:F65	L:L:K103	7.44	Yes	No	0	0	0
46	L:L:F65	L:L:Q139	23.42	Yes	No	0	0	0
47	L:L:L68	L:L:V66	2.98	No	Yes	0	0	0
48	L:L:I102	L:L:V66	3.07	Yes	Yes	0	0	0
49	L:L:L99	L:L:R67	4.86	Yes	Yes	6	0	0
50	L:L:C101	L:L:R67	2.79	Yes	Yes	6	0	0
51	L:L:C135	L:L:R67	2.79	Yes	Yes	6	0	0
52	L:L:A100	L:L:L68	4.73	No	No	0	0	0
53	L:L:C98	L:L:F70	2.79	No	No	0	0	0
54	L:L:K71	R:R:D18	4.15	No	No	0	0	6
55	L:L:L72	R:R:L19	4.15	No	No	0	0	3
56	L:L:Q73	L:L:R90	5.84	Yes	No	12	0	0
57	L:L:Q74	R:R:Y17	4.51	No	No	0	0	4
58	L:L:T75	R:R:E13	11.29	No	No	0	0	3
59	L:L:C77	L:L:C87	5.46	No	No	0	0	0
60	L:L:K79	L:L:R78	3.71	No	No	0	0	0
61	L:L:D81	L:L:R78	3.57	No	No	0	0	0
62	L:L:K79	R:R:F12	11.17	No	No	0	0	3
63	L:L:R80	L:L:W82	9	No	No	0	0	0
64	L:L:D81	L:L:E86	3.9	No	No	0	0	0
65	L:L:K84	L:L:P85	6.69	No	No	0	0	0
66	L:L:C117	L:L:C98	7.28	No	No	0	0	0
67	L:L:C101	L:L:L99	3.17	Yes	Yes	6	0	0
68	L:L:H116	L:L:L99	9	No	Yes	0	0	0
69	L:L:L99	L:L:T133	8.84	Yes	No	6	0	0
70	L:L:C135	L:L:L99	3.17	Yes	Yes	6	0	0
71	L:L:C101	L:L:C135	7.28	Yes	Yes	6	0	0
72	L:L:I102	L:L:V110	4.61	Yes	No	0	0	0
73	L:L:L111	R:R:D27	16.29	No	No	4	0	4
74	L:L:L111	R:R:L28	13.84	No	No	4	0	2
75	L:L:G112	R:R:S26	3.71	No	No	0	0	4
76	L:L:R113	R:R:S23	5.27	Yes	No	11	0	5
77	L:L:R113	R:R:E25	9.3	Yes	No	0	0	7
78	L:L:C135	L:L:L114	3.17	Yes	No	0	0	0
79	L:L:L114	L:L:V138	7.45	No	No	0	0	0
80	L:L:C117	R:R:Y21	4.03	No	No	0	0	3
81	L:L:C135	L:L:T133	6.76	Yes	No	6	0	0
82	L:L:Q134	L:L:R137	9.35	No	Yes	3	0	0
83	L:L:Q134	R:R:V179	4.3	No	No	3	0	1
84	L:L:Q134	R:R:K193	6.78	No	Yes	3	0	2
85	L:L:L136	R:R:K193	5.64	No	Yes	0	0	2
86	L:L:F150	L:L:R137	11.76	Yes	Yes	3	0	0
87	L:L:R137	R:R:Q192	11.68	Yes	Yes	3	0	4
88	L:L:R137	R:R:K193	9.9	Yes	Yes	3	0	2
89	L:L:F148	L:L:V138	6.55	Yes	No	0	0	0
90	L:L:H146	L:L:R140	5.64	No	No	0	0	0
91	L:L:R140	L:L:S147	2.64	No	No	0	0	0
92	L:L:A141	L:L:S147	3.42	Yes	No	4	0	0
93	L:L:A141	L:L:F148	4.16	Yes	Yes	4	0	0
94	L:L:F148	L:L:S147	7.93	Yes	No	4	0	0
95	L:L:F148	R:R:S26	9.25	Yes	No	0	0	4
96	L:L:Y149	R:R:E269	8.98	No	No	0	0	4
97	L:L:Y149	R:R:Y277	7.94	No	Yes	0	0	1
98	L:L:F150	L:L:Q153	5.86	Yes	Yes	0	0	0
99	L:L:F150	R:R:V179	3.93	Yes	No	3	0	1
100	L:L:F150	R:R:Y188	22.69	Yes	No	3	0	3
101	L:L:P151	R:R:Q192	3.16	No	Yes	0	0	4
102	L:L:P151	R:R:H203	3.05	No	Yes	0	0	4
103	L:L:F154	L:L:Q153	10.54	No	Yes	0	0	0
104	L:L:Q153	R:R:L186	3.99	Yes	No	0	0	3
105	L:L:F154	R:R:F101	9.65	No	No	0	0	4
106	L:L:F154	R:R:I286	5.02	No	Yes	0	0	4
107	L:L:F156	R:R:F86	10.72	Yes	Yes	2	0	7
108	L:L:F156	R:R:A117	5.55	Yes	No	2	0	6
109	L:L:F156	R:R:Y262	10.32	Yes	No	0	0	6
110	L:L:F156	R:R:F294	4.29	Yes	Yes	2	0	7
111	L:L:S157	R:R:S114	9.77	Yes	No	1	0	5
112	L:L:S157	R:R:Q118	5.78	Yes	No	0	0	5
113	L:L:S157	R:R:R176	9.22	Yes	Yes	1	0	4
114	L:L:S157	R:R:N189	8.94	Yes	No	1	0	4
115	R:R:L24	R:R:Y22	9.38	No	No	0	4	5
116	R:R:E180	R:R:Y22	6.73	No	No	0	1	5
117	R:R:E25	R:R:N182	7.89	No	No	0	7	3
118	R:R:E25	R:R:N183	6.57	No	No	0	7	5
119	R:R:D27	R:R:L28	12.21	No	No	4	4	2
120	R:R:A284	R:R:V37	3.39	Yes	No	0	2	3
121	R:R:L288	R:R:V37	2.98	No	No	0	5	3
122	R:R:A284	R:R:H38	2.93	Yes	Yes	0	2	5
123	R:R:A284	R:R:S41	3.42	Yes	No	0	2	5
124	R:R:L288	R:R:S41	6.01	No	No	0	5	5
125	R:R:L292	R:R:L44	2.77	No	No	0	7	5
126	R:R:L295	R:R:L44	5.54	No	No	0	5	5
127	R:R:L90	R:R:Y45	4.69	No	Yes	2	7	8
128	R:R:Y45	R:R:Y93	7.94	Yes	Yes	2	8	6
129	R:R:I94	R:R:Y45	4.84	No	Yes	0	6	8
130	R:R:G291	R:R:Y45	5.79	No	Yes	2	4	8
131	R:R:F294	R:R:Y45	6.19	Yes	Yes	2	7	8
132	R:R:F49	R:R:I53	5.02	No	Yes	0	7	6
133	R:R:F49	R:R:P91	5.78	No	No	0	7	9
134	R:R:C298	R:R:L51	4.76	No	No	0	7	5
135	R:R:I53	R:R:P54	3.39	Yes	No	0	6	4
136	R:R:F84	R:R:I53	12.56	Yes	Yes	0	7	6
137	R:R:I53	R:R:L87	2.85	Yes	Yes	0	6	6
138	R:R:D83	R:R:N56	13.46	Yes	Yes	7	9	9
139	R:R:F84	R:R:N56	4.83	Yes	Yes	0	7	9
140	R:R:L87	R:R:N56	2.75	Yes	Yes	7	6	9
141	R:R:N56	R:R:P301	6.52	Yes	No	7	9	9
142	R:R:A57	R:R:W61	3.89	No	No	0	2	4
143	R:R:A57	R:R:F84	4.16	No	Yes	0	2	7
144	R:R:V305	R:R:V59	3.21	No	No	0	6	8
145	R:R:A80	R:R:I60	3.25	No	No	0	8	7
146	R:R:F62	R:R:F65	8.57	No	Yes	0	7	4
147	R:R:F315	R:R:F62	9.65	No	No	0	5	7
148	R:R:F65	R:R:T63	3.89	Yes	No	0	4	7
149	R:R:L77	R:R:T63	8.84	No	No	0	6	7
150	R:R:G64	R:R:W67	4.22	No	No	0	3	6
151	R:R:F65	R:R:K66	4.96	Yes	No	8	4	5
152	R:R:F311	R:R:F65	15	Yes	Yes	8	8	4
153	R:R:F65	R:R:R314	13.9	Yes	No	8	4	6
154	R:R:K66	R:R:K69	15.8	No	No	0	5	7
155	R:R:K66	R:R:R314	7.43	No	No	8	5	6
156	R:R:K69	R:R:T70	12.01	No	No	0	7	7
157	R:R:K69	R:R:T73	9.01	No	No	0	7	8
158	R:R:T70	R:R:T72	3.14	No	No	0	7	7
159	R:R:V71	R:R:W75	8.58	No	Yes	0	6	7
160	R:R:R149	R:R:V71	3.92	Yes	No	0	7	6
161	R:R:S154	R:R:V71	4.85	Yes	No	0	7	6
162	R:R:T72	R:R:T73	3.14	No	No	0	7	8
163	R:R:L74	R:R:S154	4.5	No	Yes	0	6	7
164	R:R:F127	R:R:W75	4.01	Yes	Yes	5	7	7
165	R:R:V130	R:R:W75	8.58	No	Yes	0	6	7
166	R:R:I131	R:R:W75	7.05	No	Yes	0	8	7
167	R:R:D134	R:R:W75	3.35	No	Yes	0	8	7
168	R:R:V157	R:R:W75	3.68	No	Yes	0	6	7
169	R:R:I158	R:R:W75	3.52	Yes	Yes	5	7	7
170	R:R:F76	R:R:V305	6.55	No	No	0	8	6
171	R:R:F311	R:R:F76	3.22	Yes	No	0	8	8
172	R:R:F127	R:R:N78	15.71	Yes	No	5	7	9
173	R:R:I158	R:R:N78	5.66	Yes	No	5	7	9
174	R:R:L79	R:R:S124	3	No	No	0	9	9
175	R:R:L128	R:R:L79	5.54	No	No	0	9	9
176	R:R:D83	R:R:L87	9.5	Yes	Yes	7	9	6
177	R:R:D83	R:R:S297	2.94	Yes	No	0	9	8
178	R:R:D83	R:R:P301	8.05	Yes	No	7	9	9
179	R:R:F84	R:R:L88	3.65	Yes	No	0	7	5
180	R:R:I85	R:R:L88	2.85	No	No	0	6	5
181	R:R:I85	R:R:N120	8.5	No	No	0	6	8
182	R:R:A117	R:R:F86	2.77	No	Yes	2	6	7
183	R:R:F86	R:R:N120	6.04	Yes	No	0	7	8
184	R:R:F294	R:R:F86	11.79	Yes	Yes	2	7	7
185	R:R:F86	R:R:S297	3.96	Yes	No	0	7	8
186	R:R:C298	R:R:L87	3.17	No	Yes	0	7	6
187	R:R:F89	R:R:L88	7.31	No	No	0	6	5
188	R:R:F89	R:R:T116	9.08	No	No	0	6	5
189	R:R:L90	R:R:P91	3.28	No	No	0	7	9
190	R:R:F294	R:R:L90	15.83	Yes	No	2	7	7
191	R:R:L92	R:R:W103	6.83	Yes	Yes	1	6	9
192	R:R:F105	R:R:L92	3.65	Yes	Yes	1	7	6
193	R:R:L109	R:R:L92	5.54	No	Yes	1	5	6
194	R:R:L92	R:R:N113	6.87	Yes	No	0	6	5
195	R:R:Y93	R:R:Y96	3.97	Yes	No	0	6	6
196	R:R:T290	R:R:Y93	6.24	No	Yes	2	6	6
197	R:R:F294	R:R:Y93	3.09	Yes	Yes	2	7	6
198	R:R:W103	R:R:Y96	10.61	Yes	No	0	9	6
199	R:R:L186	R:R:Y96	3.52	No	No	0	3	6
200	R:R:P287	R:R:V97	3.53	Yes	No	0	4	5
201	R:R:H102	R:R:M99	5.25	Yes	No	1	5	4
202	R:R:M99	R:R:P104	3.35	No	No	1	4	3
203	R:R:H102	R:R:P104	7.63	Yes	No	1	5	3
204	R:R:H102	R:R:H184	3.58	Yes	No	0	5	3
205	R:R:H102	R:R:T185	13.69	Yes	No	0	5	4
206	R:R:F105	R:R:W103	16.04	Yes	Yes	1	7	9
207	R:R:C110	R:R:W103	10.45	No	Yes	1	9	9
208	R:R:C187	R:R:W103	14.37	Yes	Yes	1	9	9
209	R:R:F105	R:R:P104	5.78	Yes	No	1	7	3
210	R:R:F105	R:R:L109	8.53	Yes	No	1	7	5
211	R:R:I107	R:R:W108	3.52	No	No	14	4	1
212	R:R:I107	R:R:L173	2.85	No	No	14	4	4
213	R:R:I107	R:R:T178	7.6	No	No	0	4	5
214	R:R:L173	R:R:W108	5.69	No	No	14	4	1
215	R:R:C110	R:R:R176	6.96	No	Yes	1	9	4
216	R:R:C110	R:R:C187	7.28	No	Yes	1	9	9
217	R:R:F115	R:R:K111	6.2	No	No	0	6	7
218	R:R:K111	R:R:L173	4.23	No	No	0	7	4
219	R:R:P171	R:R:S114	3.56	No	No	0	8	5
220	R:R:R176	R:R:S114	10.54	Yes	No	1	4	5
221	R:R:N120	R:R:T116	4.39	No	No	0	8	5
222	R:R:L119	R:R:W162	5.69	No	No	0	5	9
223	R:R:M121	R:R:W259	5.82	No	Yes	0	7	8
224	R:R:F122	R:R:I168	6.28	No	No	0	6	5
225	R:R:F122	R:R:K210	4.96	No	No	0	6	6
226	R:R:A123	R:R:F127	2.77	Yes	Yes	5	6	7
227	R:R:A123	R:R:W162	5.19	Yes	No	5	6	9
228	R:R:P218	R:R:V125	3.53	No	No	0	9	7
229	R:R:F126	R:R:I161	7.54	No	No	0	5	7
230	R:R:F126	R:R:L164	6.09	No	No	0	5	4
231	R:R:F127	R:R:I158	3.77	Yes	Yes	5	7	7
232	R:R:F127	R:R:I161	7.54	Yes	No	0	7	7
233	R:R:F127	R:R:W162	7.02	Yes	No	5	7	9
234	R:R:L128	R:R:N300	4.12	No	No	13	9	9
235	R:R:L128	R:R:Y304	8.21	No	No	13	9	9
236	R:R:P218	R:R:T129	6.99	No	No	0	9	7
237	R:R:T129	R:R:T221	4.71	No	No	0	7	6
238	R:R:M222	R:R:T129	3.01	No	No	0	8	7
239	R:R:M222	R:R:S132	4.6	No	No	0	8	9
240	R:R:S132	R:R:Y226	11.45	No	No	0	9	9
241	R:R:I137	R:R:L133	4.28	No	No	0	5	6
242	R:R:D134	R:R:R149	11.91	No	Yes	0	8	7
243	R:R:H135	R:R:L139	5.14	No	No	0	9	8
244	R:R:I140	R:R:Y136	6.04	Yes	No	0	7	7
245	R:R:C225	R:R:Y136	6.72	No	No	0	6	7
246	R:R:C228	R:R:Y136	4.03	No	No	0	4	7
247	R:R:H141	R:R:I137	2.65	No	No	0	6	5
248	R:R:I137	R:R:S145	3.1	No	No	0	5	6
249	R:R:H138	R:R:R149	4.51	No	Yes	0	8	7
250	R:R:L139	R:R:L229	6.92	No	No	0	8	7
251	R:R:H141	R:R:I140	7.95	No	Yes	0	6	7
252	R:R:I140	R:R:L229	2.85	Yes	No	0	7	7
253	R:R:I140	R:R:K234	2.91	Yes	No	0	7	5
254	R:R:H141	R:R:L144	14.14	No	No	0	6	5
255	R:R:K234	R:R:P142	3.35	No	No	0	5	8
256	R:R:R149	R:R:S145	2.64	Yes	No	0	7	6
257	R:R:K152	R:R:T150	7.51	No	No	0	5	6
258	R:R:N153	R:R:T150	4.39	No	No	0	4	6
259	R:R:L151	R:R:S154	3	No	Yes	0	3	7
260	R:R:L155	R:R:S154	3	No	Yes	0	4	7
261	R:R:L163	R:R:L167	2.77	No	No	0	4	4
262	R:R:L167	R:R:S166	3	No	No	0	4	4
263	R:R:I168	R:R:I213	4.42	No	No	0	5	4
264	R:R:G170	R:R:P171	4.06	No	No	0	4	8
265	R:R:H194	R:R:Y174	6.53	No	No	0	3	5
266	R:R:F175	R:R:F191	5.36	No	Yes	0	4	5
267	R:R:F175	R:R:R202	6.41	No	No	0	4	1
268	R:R:C187	R:R:R176	2.79	Yes	Yes	1	9	4
269	R:R:N189	R:R:R176	14.46	No	Yes	1	4	4
270	R:R:D177	R:R:N190	5.39	No	Yes	0	5	3
271	R:R:D177	R:R:H194	3.78	No	No	0	5	3
272	R:R:C187	R:R:T178	5.07	Yes	No	0	9	5
273	R:R:V179	R:R:Y188	8.83	No	No	3	1	3
274	R:R:E180	R:R:T185	2.82	No	No	0	1	4
275	R:R:F181	R:R:N182	15.71	No	No	0	4	3
276	R:R:N190	R:R:Y188	10.47	Yes	No	3	3	3
277	R:R:F191	R:R:N189	7.25	Yes	No	0	5	4
278	R:R:N190	R:R:Q192	7.92	Yes	Yes	3	3	4
279	R:R:K193	R:R:N190	5.6	Yes	Yes	3	2	3
280	R:R:F191	R:R:H203	16.97	Yes	Yes	0	5	4
281	R:R:K193	R:R:Q192	10.85	Yes	Yes	3	2	4
282	R:R:D195	R:R:P196	9.66	No	No	0	2	1
283	R:R:D195	R:R:D197	9.31	No	No	15	2	4
284	R:R:D195	R:R:L198	6.79	No	Yes	15	2	4
285	R:R:D197	R:R:L198	6.79	No	Yes	15	4	4
286	R:R:I201	R:R:L198	2.85	No	Yes	0	1	4
287	R:R:L198	R:R:R202	3.64	Yes	No	0	4	1
288	R:R:H204	R:R:L200	6.43	No	No	0	4	2
289	R:R:H203	R:R:T207	2.74	Yes	No	0	4	5
290	R:R:E269	R:R:H203	4.92	No	Yes	0	4	4
291	R:R:I267	R:R:W208	3.52	No	No	0	5	4
292	R:R:I213	R:R:V209	3.07	No	No	0	4	2
293	R:R:K210	R:R:S266	3.06	No	No	0	6	5
294	R:R:F211	R:R:Y215	5.16	No	Yes	9	6	8
295	R:R:F211	R:R:H263	6.79	No	Yes	9	6	8
296	R:R:I212	R:R:L216	7.14	No	No	0	5	4
297	R:R:L219	R:R:Y215	4.69	No	Yes	0	6	8
298	R:R:W259	R:R:Y215	2.89	Yes	Yes	9	8	8
299	R:R:T260	R:R:Y215	8.74	Yes	Yes	0	5	8
300	R:R:H263	R:R:Y215	21.78	Yes	Yes	9	8	8
301	R:R:F255	R:R:L219	3.65	No	No	0	9	6
302	R:R:I224	R:R:L220	2.85	No	No	0	4	4
303	R:R:F255	R:R:M222	12.44	No	No	0	9	8
304	R:R:I224	R:R:S223	3.1	No	No	0	4	3
305	R:R:I248	R:R:Y226	10.88	No	No	0	7	9
306	R:R:V252	R:R:Y226	5.05	No	No	0	7	9
307	R:R:F231	R:R:L227	9.74	No	No	0	3	3
308	R:R:H244	R:R:L229	3.86	No	No	0	7	7
309	R:R:H244	R:R:I230	6.63	No	Yes	16	7	4
310	R:R:F245	R:R:I230	5.02	No	Yes	0	6	4
311	R:R:I230	R:R:I248	8.83	Yes	No	16	4	7
312	R:R:L239	R:R:V233	4.47	No	No	0	3	8
313	R:R:K234	R:R:R236	6.19	No	No	0	5	5
314	R:R:I238	R:R:S237	3.1	No	No	0	4	4
315	R:R:R243	R:R:T247	14.23	No	No	0	7	7
316	R:R:R243	R:R:S308	3.95	No	No	0	7	8
317	R:R:K309	R:R:R243	4.95	No	No	0	6	7
318	R:R:H244	R:R:I248	6.63	No	No	16	7	7
319	R:R:F245	R:R:W246	5.01	No	No	0	6	6
320	R:R:F245	R:R:L249	3.65	No	No	0	6	4
321	R:R:L303	R:R:V250	2.98	Yes	No	0	8	6
322	R:R:L303	R:R:V251	5.96	Yes	No	0	8	7
323	R:R:V251	R:R:Y304	5.05	No	No	0	7	9
324	R:R:F255	R:R:W259	7.02	No	Yes	0	9	8
325	R:R:T260	R:R:V256	3.17	Yes	No	0	5	5
326	R:R:C258	R:R:N296	3.15	No	Yes	0	7	9
327	R:R:H263	R:R:W259	3.17	Yes	Yes	9	8	8
328	R:R:A293	R:R:W259	5.19	No	Yes	0	8	8
329	R:R:N296	R:R:W259	18.08	Yes	Yes	0	9	8
330	R:R:P261	R:R:T260	3.5	No	Yes	0	9	5
331	R:R:L264	R:R:T260	4.42	No	Yes	0	5	5
332	R:R:P261	R:R:S289	5.34	No	No	0	9	7
333	R:R:H263	R:R:Y262	3.27	Yes	No	0	8	6
334	R:R:S266	R:R:Y262	6.36	No	No	0	5	6
335	R:R:F265	R:R:I286	7.54	No	Yes	0	4	4
336	R:R:F265	R:R:S289	5.28	No	No	0	4	7
337	R:R:H279	R:R:W268	25.39	No	No	0	1	4
338	R:R:H273	R:R:L270	9	No	No	0	3	5
339	R:R:H273	R:R:H274	8.36	No	No	18	3	3
340	R:R:H273	R:R:S278	2.79	No	No	18	3	2
341	R:R:H274	R:R:S278	8.37	No	No	18	3	2
342	R:R:N275	R:R:S276	2.98	No	No	0	3	3
343	R:R:N275	R:R:S278	5.96	No	No	0	3	2
344	R:R:S276	R:R:Y277	5.09	No	Yes	0	3	1
345	R:R:V281	R:R:Y277	5.05	No	Yes	0	1	1
346	R:R:M282	R:R:Y277	4.79	No	Yes	0	4	1
347	R:R:H280	R:R:Q283	9.89	No	No	0	3	3
348	R:R:I286	R:R:V281	3.07	Yes	No	0	4	1
349	R:R:A284	R:R:P287	3.74	Yes	Yes	0	2	4
350	R:R:I286	R:R:P287	3.39	Yes	Yes	0	4	4
351	R:R:F294	R:R:T290	3.89	Yes	No	2	7	6
352	R:R:F294	R:R:G291	3.01	Yes	No	2	7	4
353	R:R:N296	R:R:S297	2.98	Yes	No	0	9	8
354	R:R:N296	R:R:N300	9.54	Yes	No	0	9	9
355	R:R:L299	R:R:L303	4.15	No	Yes	17	7	8
356	R:R:N300	R:R:Y304	5.81	No	No	13	9	9
357	R:R:I302	R:R:L306	9.99	No	No	0	6	6
358	R:R:L306	R:R:V305	4.47	No	No	0	6	6
359	R:R:F311	R:R:S308	6.61	Yes	No	0	8	8
360	R:R:F311	R:R:R314	7.48	Yes	No	8	8	6
361	R:R:H280	R:R:M282	2.63	No	No	0	3	4
362	R:R:H38	R:R:L42	2.57	Yes	No	0	5	5
363	L:L:I102	L:L:R113	2.51	Yes	Yes	0	0	0
364	R:R:F76	R:R:I131	2.51	No	No	0	8	8
365	R:R:F231	R:R:I230	2.51	No	Yes	0	3	4
366	L:L:Y149	R:R:T271	2.5	No	No	0	0	4
367	R:R:F311	R:R:K310	2.48	Yes	No	0	8	6
368	R:R:V281	R:R:W268	2.45	No	No	0	1	4
369	R:R:F181	R:R:L24	2.44	No	No	0	4	4
370	R:R:F191	R:R:L206	2.44	Yes	No	0	5	5
371	R:R:F217	R:R:L216	2.44	No	No	0	6	4
372	R:R:I60	R:R:W61	2.35	No	No	0	7	4
373	R:R:F315	R:R:Q312	2.34	No	No	0	5	8
374	L:L:E49	L:L:R27	2.33	No	No	0	0	0
375	R:R:N14	R:R:Y15	2.33	No	No	0	7	8
376	R:R:H148	R:R:R147	2.26	No	No	0	3	5
377	L:L:H116	R:R:Y22	2.18	No	No	0	0	5
378	R:R:G169	R:R:G170	2.11	No	No	0	7	4
379	L:L:F37	R:R:Y15	2.06	No	No	0	0	8
380	R:R:G52	R:R:P54	2.03	No	No	0	8	4
381	R:R:G55	R:R:P54	2.03	No	No	0	7	4
382	R:R:G214	R:R:P218	2.03	No	No	0	5	9
383	R:R:G285	R:R:P287	2.03	No	Yes	0	6	4
384	L:L:A62	L:L:G63	1.95	No	No	0	0	0
385	L:L:A62	L:L:G142	1.95	No	No	0	0	0
386	L:L:A141	L:L:G142	1.95	Yes	No	0	0	0
387	L:L:G29	L:L:V32	1.84	No	No	0	0	0
388	R:R:G64	R:R:T63	1.82	No	No	0	3	7
389	R:R:A123	R:R:A82	1.79	Yes	No	0	6	8
390	R:R:A123	R:R:A165	1.79	Yes	No	0	6	8
391	R:R:P142	R:R:V143	1.77	No	No	0	8	5
392	L:L:G29	L:L:I102	1.76	No	Yes	0	0	0
393	R:R:G55	R:R:I58	1.76	No	No	0	7	6
394	L:L:P59	L:L:T58	1.75	No	No	0	0	0
395	L:L:A155	L:L:S157	1.71	No	Yes	0	0	0
396	R:R:G291	R:R:L44	1.71	No	No	0	4	5
397	R:R:C258	R:R:V257	1.71	No	No	0	7	5
398	L:L:G152	L:L:Q153	1.64	No	Yes	0	0	0
399	L:L:G152	R:R:E269	1.64	No	No	0	0	4
400	R:R:C46	R:R:I94	1.64	No	No	0	5	6
401	R:R:C225	R:R:I224	1.64	No	No	0	6	4
402	R:R:V36	R:R:V37	1.6	No	No	0	3	3
403	R:R:V205	R:R:V209	1.6	No	No	0	3	2
404	R:R:V253	R:R:V257	1.6	No	No	0	5	5
405	R:R:G35	R:R:H38	1.59	No	Yes	0	3	5
406	L:L:A141	R:R:L28	1.58	Yes	No	4	0	2
407	R:R:A98	R:R:L42	1.58	No	No	0	4	5
408	R:R:A48	R:R:L295	1.58	No	No	0	6	5
409	R:R:A254	R:R:L299	1.58	No	No	17	7	7
410	R:R:A254	R:R:L303	1.58	No	Yes	17	7	8
411	R:R:I240	R:R:S242	1.55	No	No	0	5	5
412	L:L:H40	L:L:P41	1.53	No	No	0	0	0
413	R:R:I267	R:R:T207	1.52	No	No	0	5	5
414	R:R:I272	R:R:T271	1.52	No	No	0	2	4
415	R:R:F105	R:R:G106	1.51	Yes	No	0	7	7
416	L:L:G29	L:L:R28	1.5	No	No	0	0	0
417	R:R:L92	R:R:S95	1.5	Yes	No	0	6	4
418	R:R:L119	R:R:S166	1.5	No	No	0	5	4
419	R:R:L288	R:R:V40	1.49	No	No	0	5	6
420	R:R:L47	R:R:V43	1.49	No	No	0	4	5
421	R:R:N153	R:R:V157	1.48	No	No	0	4	6
422	R:R:I60	R:R:I81	1.47	No	No	0	7	5
423	R:R:I81	R:R:I85	1.47	No	No	0	5	6
424	R:R:I158	R:R:I159	1.47	Yes	No	0	7	3
425	R:R:I212	R:R:I213	1.47	No	No	0	5	4
426	R:R:K232	R:R:K235	1.44	No	No	0	5	4
427	L:L:C77	L:L:R78	1.39	No	No	0	0	0
428	R:R:L139	R:R:L239	1.38	No	No	0	8	3
429	R:R:I307	R:R:Q312	1.37	No	No	0	6	8
430	L:L:R67	L:L:V56	1.31	Yes	No	0	0	0
431	L:L:Q73	L:L:Q74	1.28	Yes	No	0	0	0
432	R:R:H184	R:R:N100	1.28	No	No	0	3	3
433	R:R:F231	R:R:K232	1.24	No	No	0	3	5
434	R:R:F160	R:R:L164	1.22	No	No	0	3	4
435	L:L:D81	L:L:W82	1.12	No	No	0	0	0
436	R:R:H38	R:R:W39	1.06	Yes	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Q26	7.955	4	10	0
2	L:L:E36	11.2525	4	11	0
3	L:L:F47	16.5925	4	0	0
4	L:L:F65	10.06	4	0	0
5	L:L:V66	4.4125	4	10	0
6	L:L:R67	2.9375	4	6	0
7	L:L:Q73	11.565	4	12	0
8	L:L:L99	5.808	5	6	0
9	L:L:C101	4.3575	4	6	0
10	L:L:I102	2.9875	4	0	0
11	L:L:R113	11.54	4	11	0
12	L:L:C135	4.634	5	6	0
13	L:L:R137	10.6725	4	3	0
14	L:L:A141	2.7775	4	4	0
15	L:L:F148	6.9725	4	4	0
16	L:L:F150	11.06	4	3	0
17	L:L:Q153	5.5075	4	0	0
18	L:L:F156	7.72	4	2	0
19	L:L:S157	7.084	5	1	0
20	R:R:H38	2.0375	4	0	5
21	R:R:Y45	5.89	5	2	8
22	R:R:I53	5.955	4	0	6
23	R:R:N56	6.89	4	7	9
24	R:R:F65	9.264	5	8	4
25	R:R:W75	5.53857	7	5	7
26	R:R:D83	8.4875	4	7	9
27	R:R:F84	6.3	4	0	7
28	R:R:F86	7.056	5	2	7
29	R:R:L87	4.5675	4	7	6
30	R:R:L92	4.878	5	1	6
31	R:R:Y93	5.31	4	2	6
32	R:R:H102	7.5375	4	1	5
33	R:R:W103	11.66	5	1	9
34	R:R:F105	7.102	5	1	7
35	R:R:A123	2.885	4	5	6
36	R:R:F127	6.80333	6	5	7
37	R:R:I140	4.9375	4	0	7
38	R:R:R149	5.745	4	0	7
39	R:R:S154	3.8375	4	0	7
40	R:R:I158	3.605	4	5	7
41	R:R:R176	8.794	5	1	4
42	R:R:C187	7.3775	4	1	9
43	R:R:N190	7.345	4	3	3
44	R:R:F191	8.005	4	0	5
45	R:R:Q192	8.4025	4	3	4
46	R:R:K193	7.754	5	3	2
47	R:R:L198	5.0175	4	15	4
48	R:R:H203	6.92	4	0	4
49	R:R:Y215	8.652	5	9	8
50	R:R:I230	5.7475	4	16	4
51	R:R:W259	7.02833	6	9	8
52	R:R:T260	4.9575	4	0	5
53	R:R:H263	8.7525	4	9	8
54	R:R:Y277	5.7175	4	0	1
55	R:R:A284	3.37	4	0	2
56	R:R:I286	4.755	4	0	4
57	R:R:P287	3.1725	4	0	4
58	R:R:F294	6.87	7	2	7
59	R:R:N296	8.4375	4	0	9
60	R:R:L303	3.6675	4	17	8
61	R:R:F311	6.958	5	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H116	L:L:L99	20.7849	9	No	Yes	0	0	0
2	L:L:H116	R:R:Y22	21.4002	2.18	No	No	0	0	5
3	R:R:L24	R:R:Y22	40.5373	9.38	No	No	0	4	5
4	R:R:F181	R:R:L24	39.9905	2.44	No	No	0	4	4
5	R:R:F181	R:R:N182	39.4415	15.71	No	No	0	4	3
6	R:R:E25	R:R:N182	38.8906	7.89	No	No	0	7	3
7	L:L:R113	R:R:E25	37.7824	9.3	Yes	No	0	0	7
8	L:L:I102	L:L:R113	10.6524	2.51	Yes	Yes	0	0	0
9	L:L:E36	L:L:R113	27.3863	29.08	Yes	Yes	11	0	0
10	L:L:E36	R:R:Y21	25.6389	4.49	Yes	No	0	0	3
11	L:L:F37	R:R:Y21	20.7818	8.25	No	No	0	0	3
12	L:L:F37	R:R:Y15	18.9265	2.06	No	No	0	0	8
13	R:R:N14	R:R:Y15	18.3028	2.33	No	No	0	7	8
14	L:L:W45	R:R:N14	15.7876	12.43	No	No	0	0	7
15	L:L:W45	R:R:F12	15.1536	10.02	No	No	0	0	3
16	L:L:K79	R:R:F12	14.5176	11.17	No	No	0	0	3
17	L:L:K79	L:L:R78	13.8794	3.71	No	No	0	0	0
18	L:L:C77	L:L:R78	10.6575	1.39	No	No	0	0	0
19	L:L:C77	L:L:C87	10.007	5.46	No	No	0	0	0
20	R:R:E180	R:R:Y22	57.8834	6.73	No	No	0	1	5
21	R:R:E180	R:R:T185	58.3576	2.82	No	No	0	1	4
22	R:R:H102	R:R:T185	58.8298	13.69	Yes	No	0	5	4
23	R:R:H102	R:R:P104	60.1247	7.63	Yes	No	1	5	3
24	R:R:F105	R:R:P104	61.1592	5.78	Yes	No	1	7	3
25	R:R:F105	R:R:W103	62.1896	16.04	Yes	Yes	1	7	9
26	R:R:W103	R:R:Y96	78.578	10.61	Yes	No	0	9	6
27	R:R:L186	R:R:Y96	21.5704	3.52	No	No	0	3	6
28	L:L:Q153	R:R:L186	21.0713	3.99	Yes	No	0	0	3
29	L:L:F150	L:L:Q153	13.2423	5.86	Yes	Yes	0	0	0
30	L:L:F154	L:L:Q153	15.5261	10.54	No	Yes	0	0	0
31	L:L:F154	R:R:I286	15.7793	5.02	No	Yes	0	0	4
32	R:R:I286	R:R:V281	11.5063	3.07	Yes	No	0	4	1
33	R:R:C110	R:R:W103	11.4773	10.45	No	Yes	1	9	9
34	R:R:C110	R:R:R176	10.9211	6.96	No	Yes	1	9	4
35	R:R:N189	R:R:R176	12.8719	14.46	No	Yes	1	4	4
36	R:R:F191	R:R:N189	12.3064	7.25	Yes	No	0	5	4
37	R:R:C187	R:R:W103	15.0883	14.37	Yes	Yes	1	9	9
38	R:R:C187	R:R:R176	11.195	2.79	Yes	Yes	1	9	4
39	R:R:Y93	R:R:Y96	83.2878	3.97	Yes	No	0	6	6
40	R:R:F294	R:R:Y93	78.9578	3.09	Yes	Yes	2	7	6
41	L:L:F156	R:R:F294	37.91	4.29	Yes	Yes	2	0	7
42	R:R:F294	R:R:F86	42.1435	11.79	Yes	Yes	2	7	7
43	L:L:F156	R:R:Y262	38.1829	10.32	Yes	No	0	0	6
44	R:R:I286	R:R:P287	10.7406	3.39	Yes	Yes	0	4	4
45	R:R:F86	R:R:S297	41.0883	3.96	Yes	No	0	7	8
46	R:R:H263	R:R:Y262	38.0117	3.27	Yes	No	0	8	6
47	R:R:H263	R:R:W259	36.558	3.17	Yes	Yes	9	8	8
48	R:R:F255	R:R:W259	88.3183	7.02	No	Yes	0	9	8
49	R:R:F255	R:R:M222	100	12.44	No	No	0	9	8
50	R:R:M222	R:R:S132	97.2731	4.6	No	No	0	8	9
51	R:R:S132	R:R:Y226	96.8103	11.45	No	No	0	9	9
52	R:R:I248	R:R:Y226	95.8785	10.88	No	No	0	7	9
53	R:R:H244	R:R:I248	90.3874	6.63	No	No	16	7	7
54	R:R:H244	R:R:L229	91.095	3.86	No	No	0	7	7
55	R:R:I140	R:R:L229	88.6254	2.85	Yes	No	0	7	7
56	R:R:H141	R:R:I140	83.0098	7.95	No	Yes	0	6	7
57	R:R:H141	R:R:I137	81.9618	2.65	No	No	0	6	5
58	R:R:I137	R:R:S145	80.9054	3.1	No	No	0	5	6
59	R:R:R149	R:R:S145	80.3742	2.64	Yes	No	0	7	6
60	R:R:R149	R:R:V71	40.9814	3.92	Yes	No	0	7	6
61	R:R:V71	R:R:W75	37.9723	8.58	No	Yes	0	6	7
62	R:R:I131	R:R:W75	45.962	7.05	No	Yes	0	8	7
63	R:R:F76	R:R:I131	44.6422	2.51	No	No	0	8	8
64	R:R:N296	R:R:S297	42.2919	2.98	Yes	No	0	9	8
65	R:R:N296	R:R:W259	42.2255	18.08	Yes	Yes	0	9	8
66	R:R:D134	R:R:R149	38.3334	11.91	No	Yes	0	8	7
67	R:R:D134	R:R:W75	37.7305	3.35	No	Yes	0	8	7
68	R:R:F311	R:R:F76	38.02	3.22	Yes	No	0	8	8
69	R:R:F311	R:R:F65	20.4663	15	Yes	Yes	8	8	4
70	R:R:K66	R:R:K69	13.7009	15.8	No	No	0	5	7
71	R:R:F127	R:R:W75	19.1745	4.01	Yes	Yes	5	7	7
72	R:R:L219	R:R:Y215	12.3499	4.69	No	Yes	0	6	8
73	R:R:T260	R:R:Y215	25.8776	8.74	Yes	Yes	0	5	8
74	R:R:F265	R:R:I286	23.9206	7.54	No	Yes	0	4	4
75	R:R:F265	R:R:S289	24.0638	5.28	No	No	0	4	7
76	R:R:P261	R:R:S289	24.2464	5.34	No	No	0	9	7
77	R:R:P261	R:R:T260	24.4332	3.5	No	Yes	0	9	5
78	R:R:F255	R:R:L219	12.2213	3.65	No	No	0	9	6
79	R:R:W259	R:R:Y215	13.3803	2.89	Yes	Yes	9	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E36	R:R:Y21	4.49	11	Yes	No	0	3	0	1
L:L:E36	R:R:S23	4.31	11	Yes	No	0	5	0	1
L:L:F37	R:R:L19	4.87	0	No	No	0	3	0	1
L:L:F37	R:R:Y21	8.25	0	No	No	0	3	0	1
L:L:P41	R:R:N14	9.77	0	No	No	0	7	0	1
L:L:W45	R:R:F12	10.02	0	No	No	0	3	0	1
L:L:W45	R:R:N14	12.43	0	No	No	0	7	0	1
L:L:K71	R:R:D18	4.15	0	No	No	0	6	0	1
L:L:L72	R:R:L19	4.15	0	No	No	0	3	0	1
L:L:Q74	R:R:Y17	4.51	0	No	No	0	4	0	1
L:L:T75	R:R:E13	11.29	0	No	No	0	3	0	1
L:L:K79	R:R:F12	11.17	0	No	No	0	3	0	1
L:L:L111	R:R:D27	16.29	4	No	No	0	4	0	1
L:L:L111	R:R:L28	13.84	4	No	No	0	2	0	1
L:L:G112	R:R:S26	3.71	0	No	No	0	4	0	1
L:L:R113	R:R:S23	5.27	11	Yes	No	0	5	0	1
L:L:R113	R:R:E25	9.3	11	Yes	No	0	7	0	1
L:L:C117	R:R:Y21	4.03	0	No	No	0	3	0	1
L:L:Q134	R:R:V179	4.3	3	No	No	0	1	0	1
L:L:Q134	R:R:K193	6.78	3	No	Yes	0	2	0	1
L:L:L136	R:R:K193	5.64	0	No	Yes	0	2	0	1
L:L:R137	R:R:Q192	11.68	3	Yes	Yes	0	4	0	1
L:L:R137	R:R:K193	9.9	3	Yes	Yes	0	2	0	1
L:L:F148	R:R:S26	9.25	4	Yes	No	0	4	0	1
L:L:Y149	R:R:E269	8.98	0	No	No	0	4	0	1
L:L:Y149	R:R:Y277	7.94	0	No	Yes	0	1	0	1
L:L:F150	R:R:V179	3.93	3	Yes	No	0	1	0	1
L:L:F150	R:R:Y188	22.69	3	Yes	No	0	3	0	1
L:L:P151	R:R:Q192	3.16	0	No	Yes	0	4	0	1
L:L:P151	R:R:H203	3.05	0	No	Yes	0	4	0	1
L:L:Q153	R:R:L186	3.99	0	Yes	No	0	3	0	1
L:L:F154	R:R:F101	9.65	0	No	No	0	4	0	1
L:L:F154	R:R:I286	5.02	0	No	Yes	0	4	0	1
L:L:F156	R:R:F86	10.72	2	Yes	Yes	0	7	0	1
L:L:F156	R:R:A117	5.55	2	Yes	No	0	6	0	1
L:L:F156	R:R:Y262	10.32	2	Yes	No	0	6	0	1
L:L:F156	R:R:F294	4.29	2	Yes	Yes	0	7	0	1
L:L:S157	R:R:S114	9.77	1	Yes	No	0	5	0	1
L:L:S157	R:R:Q118	5.78	1	Yes	No	0	5	0	1
L:L:S157	R:R:R176	9.22	1	Yes	Yes	0	4	0	1
L:L:S157	R:R:N189	8.94	1	Yes	No	0	4	0	1
R:R:L24	R:R:Y22	9.38	0	No	No	4	5	2	1
R:R:E180	R:R:Y22	6.73	0	No	No	1	5	2	1
R:R:E25	R:R:N182	7.89	0	No	No	7	3	1	2
R:R:E25	R:R:N183	6.57	0	No	No	7	5	1	2
R:R:D27	R:R:L28	12.21	4	No	No	4	2	1	1
R:R:L90	R:R:Y45	4.69	2	No	Yes	7	8	2	2
R:R:Y45	R:R:Y93	7.94	2	Yes	Yes	8	6	2	2
R:R:G291	R:R:Y45	5.79	2	No	Yes	4	8	2	2
R:R:F294	R:R:Y45	6.19	2	Yes	Yes	7	8	1	2
R:R:A117	R:R:F86	2.77	2	No	Yes	6	7	1	1
R:R:F86	R:R:N120	6.04	2	Yes	No	7	8	1	2
R:R:F294	R:R:F86	11.79	2	Yes	Yes	7	7	1	1
R:R:F86	R:R:S297	3.96	2	Yes	No	7	8	1	2
R:R:F294	R:R:L90	15.83	2	Yes	No	7	7	1	2
R:R:Y93	R:R:Y96	3.97	2	Yes	No	6	6	2	2
R:R:T290	R:R:Y93	6.24	2	No	Yes	6	6	2	2
R:R:F294	R:R:Y93	3.09	2	Yes	Yes	7	6	1	2
R:R:L186	R:R:Y96	3.52	0	No	No	3	6	1	2
R:R:C110	R:R:R176	6.96	1	No	Yes	9	4	2	1
R:R:C110	R:R:C187	7.28	1	No	Yes	9	9	2	2
R:R:P171	R:R:S114	3.56	0	No	No	8	5	2	1
R:R:R176	R:R:S114	10.54	1	Yes	No	4	5	1	1
R:R:C187	R:R:R176	2.79	1	Yes	Yes	9	4	2	1
R:R:N189	R:R:R176	14.46	1	No	Yes	4	4	1	1
R:R:V179	R:R:Y188	8.83	3	No	No	1	3	1	1
R:R:N190	R:R:Y188	10.47	3	Yes	No	3	3	2	1
R:R:F191	R:R:N189	7.25	0	Yes	No	5	4	2	1
R:R:N190	R:R:Q192	7.92	3	Yes	Yes	3	4	2	1
R:R:K193	R:R:N190	5.6	3	Yes	Yes	2	3	1	2
R:R:F191	R:R:H203	16.97	0	Yes	Yes	5	4	2	1
R:R:K193	R:R:Q192	10.85	3	Yes	Yes	2	4	1	1
R:R:H203	R:R:T207	2.74	0	Yes	No	4	5	1	2
R:R:E269	R:R:H203	4.92	0	No	Yes	4	4	1	1
R:R:H263	R:R:Y262	3.27	9	Yes	No	8	6	2	1
R:R:S266	R:R:Y262	6.36	0	No	No	5	6	2	1
R:R:F265	R:R:I286	7.54	0	No	Yes	4	4	2	1
R:R:S276	R:R:Y277	5.09	0	No	Yes	3	1	2	1
R:R:V281	R:R:Y277	5.05	0	No	Yes	1	1	2	1
R:R:M282	R:R:Y277	4.79	0	No	Yes	4	1	2	1
R:R:I286	R:R:V281	3.07	0	Yes	No	4	1	1	2
R:R:I286	R:R:P287	3.39	0	Yes	Yes	4	4	1	2
R:R:F294	R:R:T290	3.89	2	Yes	No	7	6	1	2
R:R:F294	R:R:G291	3.01	2	Yes	No	7	4	1	2
L:L:Y149	R:R:T271	2.5	0	No	No	0	4	0	1
R:R:N14	R:R:Y15	2.33	0	No	No	7	8	1	1
L:L:H116	R:R:Y22	2.18	0	No	No	0	5	0	1
L:L:F37	R:R:Y15	2.06	0	No	No	0	8	0	1
L:L:G152	R:R:E269	1.64	0	No	No	0	4	0	1
L:L:A141	R:R:L28	1.58	4	Yes	No	0	2	0	1
R:R:I272	R:R:T271	1.52	0	No	No	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L3Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	386
Number of Links	436
Number of Hubs	61
Number of Links mediated by Hubs	215
Number of Communities	18
Number of Nodes involved in Communities	86
Number of Links involved in Communities	111

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	155314
Length Of Smallest Path	3
Average Path Length	24.8515
Length of Longest Path	58
Minimum Path Strength	1.325
Average Path Strength	6.74168
Maximum Path Strength	26.355
Minimum Path Correlation	0.7
Average Path Correlation	0.960499
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	47.0342
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.3045
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • antifungal humoral response • response to external biotic stimulus • response to fungus • cellular developmental process • cell differentiation • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • response to activity • digestive system development • tube development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • innate immune response • lipid catabolic process • catabolic process • regulation of catabolic process • regulation of lipid catabolic process • response to nutrient levels • response to caloric restriction • regulation of cell motility • macrophage migration • positive regulation of cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • granulocyte chemotaxis • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • cellular response to peptide hormone stimulus • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • macromolecule metabolic process • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • positive regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • platelet dense granule lumen • cytoplasmic vesicle • platelet dense granule • secretory granule • secretory vesicle • extracellular matrix • external encapsulating structure • amide binding • adipokinetic hormone binding • peptide hormone binding • hormone binding • molecular transducer activity • protein-hormone receptor activity • adipokinetic hormone receptor activity • signaling receptor activity • neuropeptide binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide signaling pathway • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>9L3Y_nogp_Chain_R F E N Y S Y D L D Y Y S L E S D L G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N F Q K H D P D L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S I L I S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F Q A R F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Retinoic acid receptor responder protein 2	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Retinoic acid receptor responder protein 2	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838

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