psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E24	L:L:T23	2.82	No	No	0	0	0
2	L:L:Q26	L:L:T23	9.92	Yes	No	0	0	0
3	L:L:A25	L:L:I64	3.25	No	No	0	0	0
4	L:L:A55	L:L:Q26	4.55	No	Yes	0	0	0
5	L:L:D57	L:L:Q26	13.05	No	Yes	10	0	0
6	L:L:Q26	L:L:V66	4.3	Yes	Yes	10	0	0
7	L:L:L30	L:L:R27	14.58	No	No	0	0	0
8	L:L:F70	L:L:L30	4.87	No	No	0	0	0
9	L:L:Q31	L:L:V32	4.3	No	No	0	0	0
10	L:L:E35	L:L:Q31	15.29	No	No	0	0	0
11	L:L:A33	L:L:V115	5.09	No	No	0	0	0
12	L:L:L34	L:L:P85	3.28	No	No	0	0	0
13	L:L:E35	L:L:K83	22.95	No	No	0	0	0
14	L:L:E36	L:L:R113	29.08	Yes	Yes	11	0	0
15	L:L:E36	L:L:V115	7.13	Yes	No	0	0	0
16	L:L:E36	R:R:Y21	4.49	Yes	No	0	0	3
17	L:L:E36	R:R:S23	4.31	Yes	No	11	0	5
18	L:L:F37	R:R:L19	4.87	No	No	0	0	3
19	L:L:F37	R:R:Y21	8.25	No	No	0	0	3
20	L:L:A46	L:L:H38	5.85	No	No	0	0	0
21	L:L:H40	L:L:K39	3.93	No	No	0	0	0
22	L:L:P41	R:R:N14	9.77	No	No	0	0	7
23	L:L:W45	R:R:F12	10.02	No	No	0	0	3
24	L:L:W45	R:R:N14	12.43	No	No	0	0	7
25	L:L:F47	L:L:Q48	16.4	Yes	No	0	0	0
26	L:L:F47	L:L:Q73	36.31	Yes	Yes	0	0	0
27	L:L:F47	L:L:S76	5.28	Yes	No	0	0	0
28	L:L:C87	L:L:F47	8.38	No	Yes	0	0	0
29	L:L:P85	L:L:Q48	4.74	No	No	0	0	0
30	L:L:E49	L:L:V52	8.56	No	No	0	0	0
31	L:L:S51	L:L:T50	3.2	No	No	0	0	0
32	L:L:Q73	L:L:T50	2.83	Yes	No	12	0	0
33	L:L:R90	L:L:T50	11.64	No	No	12	0	0
34	L:L:K71	L:L:S51	4.59	No	No	0	0	0
35	L:L:E53	L:L:E69	10.15	No	No	0	0	0
36	L:L:E53	L:L:K97	5.4	No	No	0	0	0
37	L:L:D57	L:L:V66	7.3	No	Yes	10	0	0
38	L:L:F65	L:L:T58	5.19	Yes	No	0	0	0
39	L:L:I64	L:L:P59	3.39	No	No	0	0	0
40	L:L:F60	L:L:P61	4.33	No	No	0	0	0
41	L:L:K103	L:L:P61	6.69	No	No	0	0	0
42	L:L:P61	L:L:Q139	7.9	No	No	0	0	0
43	L:L:A62	L:L:K103	3.21	No	No	0	0	0
44	L:L:C101	L:L:F65	4.19	Yes	Yes	0	0	0
45	L:L:F65	L:L:K103	7.44	Yes	No	0	0	0
46	L:L:F65	L:L:Q139	23.42	Yes	No	0	0	0
47	L:L:L68	L:L:V66	2.98	No	Yes	0	0	0
48	L:L:I102	L:L:V66	3.07	Yes	Yes	0	0	0
49	L:L:L99	L:L:R67	4.86	Yes	Yes	6	0	0
50	L:L:C101	L:L:R67	2.79	Yes	Yes	6	0	0
51	L:L:C135	L:L:R67	2.79	Yes	Yes	6	0	0
52	L:L:A100	L:L:L68	4.73	No	No	0	0	0
53	L:L:C98	L:L:F70	2.79	No	No	0	0	0
54	L:L:K71	R:R:D18	4.15	No	No	0	0	6
55	L:L:L72	R:R:L19	4.15	No	No	0	0	3
56	L:L:Q73	L:L:R90	5.84	Yes	No	12	0	0
57	L:L:Q74	R:R:Y17	4.51	No	No	0	0	4
58	L:L:T75	R:R:E13	11.29	No	No	0	0	3
59	L:L:C77	L:L:C87	5.46	No	No	0	0	0
60	L:L:K79	L:L:R78	3.71	No	No	0	0	0
61	L:L:D81	L:L:R78	3.57	No	No	0	0	0
62	L:L:K79	R:R:F12	11.17	No	No	0	0	3
63	L:L:R80	L:L:W82	9	No	No	0	0	0
64	L:L:D81	L:L:E86	3.9	No	No	0	0	0
65	L:L:K84	L:L:P85	6.69	No	No	0	0	0
66	L:L:C117	L:L:C98	7.28	No	No	0	0	0
67	L:L:C101	L:L:L99	3.17	Yes	Yes	6	0	0
68	L:L:H116	L:L:L99	9	No	Yes	0	0	0
69	L:L:L99	L:L:T133	8.84	Yes	No	6	0	0
70	L:L:C135	L:L:L99	3.17	Yes	Yes	6	0	0
71	L:L:C101	L:L:C135	7.28	Yes	Yes	6	0	0
72	L:L:I102	L:L:V110	4.61	Yes	No	0	0	0
73	L:L:L111	R:R:D27	16.29	No	No	4	0	4
74	L:L:L111	R:R:L28	13.84	No	No	4	0	2
75	L:L:G112	R:R:S26	3.71	No	No	0	0	4
76	L:L:R113	R:R:S23	5.27	Yes	No	11	0	5
77	L:L:R113	R:R:E25	9.3	Yes	No	0	0	7
78	L:L:C135	L:L:L114	3.17	Yes	No	0	0	0
79	L:L:L114	L:L:V138	7.45	No	No	0	0	0
80	L:L:C117	R:R:Y21	4.03	No	No	0	0	3
81	L:L:C135	L:L:T133	6.76	Yes	No	6	0	0
82	L:L:Q134	L:L:R137	9.35	No	Yes	3	0	0
83	L:L:Q134	R:R:V179	4.3	No	No	3	0	1
84	L:L:Q134	R:R:K193	6.78	No	Yes	3	0	2
85	L:L:L136	R:R:K193	5.64	No	Yes	0	0	2
86	L:L:F150	L:L:R137	11.76	Yes	Yes	3	0	0
87	L:L:R137	R:R:Q192	11.68	Yes	Yes	3	0	4
88	L:L:R137	R:R:K193	9.9	Yes	Yes	3	0	2
89	L:L:F148	L:L:V138	6.55	Yes	No	0	0	0
90	L:L:H146	L:L:R140	5.64	No	No	0	0	0
91	L:L:R140	L:L:S147	2.64	No	No	0	0	0
92	L:L:A141	L:L:S147	3.42	Yes	No	4	0	0
93	L:L:A141	L:L:F148	4.16	Yes	Yes	4	0	0
94	L:L:F148	L:L:S147	7.93	Yes	No	4	0	0
95	L:L:F148	R:R:S26	9.25	Yes	No	0	0	4
96	L:L:Y149	R:R:E269	8.98	No	No	0	0	4
97	L:L:Y149	R:R:Y277	7.94	No	Yes	0	0	1
98	L:L:F150	L:L:Q153	5.86	Yes	Yes	0	0	0
99	L:L:F150	R:R:V179	3.93	Yes	No	3	0	1
100	L:L:F150	R:R:Y188	22.69	Yes	No	3	0	3
101	L:L:P151	R:R:Q192	3.16	No	Yes	0	0	4
102	L:L:P151	R:R:H203	3.05	No	Yes	0	0	4
103	L:L:F154	L:L:Q153	10.54	No	Yes	0	0	0
104	L:L:Q153	R:R:L186	3.99	Yes	No	0	0	3
105	L:L:F154	R:R:F101	9.65	No	No	0	0	4
106	L:L:F154	R:R:I286	5.02	No	Yes	0	0	4
107	L:L:F156	R:R:F86	10.72	Yes	Yes	2	0	7
108	L:L:F156	R:R:A117	5.55	Yes	No	2	0	6
109	L:L:F156	R:R:Y262	10.32	Yes	No	0	0	6
110	L:L:F156	R:R:F294	4.29	Yes	Yes	2	0	7
111	L:L:S157	R:R:S114	9.77	Yes	No	1	0	5
112	L:L:S157	R:R:Q118	5.78	Yes	No	0	0	5
113	L:L:S157	R:R:R176	9.22	Yes	Yes	1	0	4
114	L:L:S157	R:R:N189	8.94	Yes	No	1	0	4
115	R:R:L24	R:R:Y22	9.38	No	No	0	4	5
116	R:R:E180	R:R:Y22	6.73	No	No	0	1	5
117	R:R:E25	R:R:N182	7.89	No	No	0	7	3
118	R:R:E25	R:R:N183	6.57	No	No	0	7	5
119	R:R:D27	R:R:L28	12.21	No	No	4	4	2
120	R:R:A284	R:R:V37	3.39	Yes	No	0	2	3
121	R:R:L288	R:R:V37	2.98	No	No	0	5	3
122	R:R:A284	R:R:H38	2.93	Yes	Yes	0	2	5
123	R:R:A284	R:R:S41	3.42	Yes	No	0	2	5
124	R:R:L288	R:R:S41	6.01	No	No	0	5	5
125	R:R:L292	R:R:L44	2.77	No	No	0	7	5
126	R:R:L295	R:R:L44	5.54	No	No	0	5	5
127	R:R:L90	R:R:Y45	4.69	No	Yes	2	7	8
128	R:R:Y45	R:R:Y93	7.94	Yes	Yes	2	8	6
129	R:R:I94	R:R:Y45	4.84	No	Yes	0	6	8
130	R:R:G291	R:R:Y45	5.79	No	Yes	2	4	8
131	R:R:F294	R:R:Y45	6.19	Yes	Yes	2	7	8
132	R:R:F49	R:R:I53	5.02	No	Yes	0	7	6
133	R:R:F49	R:R:P91	5.78	No	No	0	7	9
134	R:R:C298	R:R:L51	4.76	No	No	0	7	5
135	R:R:I53	R:R:P54	3.39	Yes	No	0	6	4
136	R:R:F84	R:R:I53	12.56	Yes	Yes	0	7	6
137	R:R:I53	R:R:L87	2.85	Yes	Yes	0	6	6
138	R:R:D83	R:R:N56	13.46	Yes	Yes	7	9	9
139	R:R:F84	R:R:N56	4.83	Yes	Yes	0	7	9
140	R:R:L87	R:R:N56	2.75	Yes	Yes	7	6	9
141	R:R:N56	R:R:P301	6.52	Yes	No	7	9	9
142	R:R:A57	R:R:W61	3.89	No	No	0	2	4
143	R:R:A57	R:R:F84	4.16	No	Yes	0	2	7
144	R:R:V305	R:R:V59	3.21	No	No	0	6	8
145	R:R:A80	R:R:I60	3.25	No	No	0	8	7
146	R:R:F62	R:R:F65	8.57	No	Yes	0	7	4
147	R:R:F315	R:R:F62	9.65	No	No	0	5	7
148	R:R:F65	R:R:T63	3.89	Yes	No	0	4	7
149	R:R:L77	R:R:T63	8.84	No	No	0	6	7
150	R:R:G64	R:R:W67	4.22	No	No	0	3	6
151	R:R:F65	R:R:K66	4.96	Yes	No	8	4	5
152	R:R:F311	R:R:F65	15	Yes	Yes	8	8	4
153	R:R:F65	R:R:R314	13.9	Yes	No	8	4	6
154	R:R:K66	R:R:K69	15.8	No	No	0	5	7
155	R:R:K66	R:R:R314	7.43	No	No	8	5	6
156	R:R:K69	R:R:T70	12.01	No	No	0	7	7
157	R:R:K69	R:R:T73	9.01	No	No	0	7	8
158	R:R:T70	R:R:T72	3.14	No	No	0	7	7
159	R:R:V71	R:R:W75	8.58	No	Yes	0	6	7
160	R:R:R149	R:R:V71	3.92	Yes	No	0	7	6
161	R:R:S154	R:R:V71	4.85	Yes	No	0	7	6
162	R:R:T72	R:R:T73	3.14	No	No	0	7	8
163	R:R:L74	R:R:S154	4.5	No	Yes	0	6	7
164	R:R:F127	R:R:W75	4.01	Yes	Yes	5	7	7
165	R:R:V130	R:R:W75	8.58	No	Yes	0	6	7
166	R:R:I131	R:R:W75	7.05	No	Yes	0	8	7
167	R:R:D134	R:R:W75	3.35	No	Yes	0	8	7
168	R:R:V157	R:R:W75	3.68	No	Yes	0	6	7
169	R:R:I158	R:R:W75	3.52	Yes	Yes	5	7	7
170	R:R:F76	R:R:V305	6.55	No	No	0	8	6
171	R:R:F311	R:R:F76	3.22	Yes	No	0	8	8
172	R:R:F127	R:R:N78	15.71	Yes	No	5	7	9
173	R:R:I158	R:R:N78	5.66	Yes	No	5	7	9
174	R:R:L79	R:R:S124	3	No	No	0	9	9
175	R:R:L128	R:R:L79	5.54	No	No	0	9	9
176	R:R:D83	R:R:L87	9.5	Yes	Yes	7	9	6
177	R:R:D83	R:R:S297	2.94	Yes	No	0	9	8
178	R:R:D83	R:R:P301	8.05	Yes	No	7	9	9
179	R:R:F84	R:R:L88	3.65	Yes	No	0	7	5
180	R:R:I85	R:R:L88	2.85	No	No	0	6	5
181	R:R:I85	R:R:N120	8.5	No	No	0	6	8
182	R:R:A117	R:R:F86	2.77	No	Yes	2	6	7
183	R:R:F86	R:R:N120	6.04	Yes	No	0	7	8
184	R:R:F294	R:R:F86	11.79	Yes	Yes	2	7	7
185	R:R:F86	R:R:S297	3.96	Yes	No	0	7	8
186	R:R:C298	R:R:L87	3.17	No	Yes	0	7	6
187	R:R:F89	R:R:L88	7.31	No	No	0	6	5
188	R:R:F89	R:R:T116	9.08	No	No	0	6	5
189	R:R:L90	R:R:P91	3.28	No	No	0	7	9
190	R:R:F294	R:R:L90	15.83	Yes	No	2	7	7
191	R:R:L92	R:R:W103	6.83	Yes	Yes	1	6	9
192	R:R:F105	R:R:L92	3.65	Yes	Yes	1	7	6
193	R:R:L109	R:R:L92	5.54	No	Yes	1	5	6
194	R:R:L92	R:R:N113	6.87	Yes	No	0	6	5
195	R:R:Y93	R:R:Y96	3.97	Yes	No	0	6	6
196	R:R:T290	R:R:Y93	6.24	No	Yes	2	6	6
197	R:R:F294	R:R:Y93	3.09	Yes	Yes	2	7	6
198	R:R:W103	R:R:Y96	10.61	Yes	No	0	9	6
199	R:R:L186	R:R:Y96	3.52	No	No	0	3	6
200	R:R:P287	R:R:V97	3.53	Yes	No	0	4	5
201	R:R:H102	R:R:M99	5.25	Yes	No	1	5	4
202	R:R:M99	R:R:P104	3.35	No	No	1	4	3
203	R:R:H102	R:R:P104	7.63	Yes	No	1	5	3
204	R:R:H102	R:R:H184	3.58	Yes	No	0	5	3
205	R:R:H102	R:R:T185	13.69	Yes	No	0	5	4
206	R:R:F105	R:R:W103	16.04	Yes	Yes	1	7	9
207	R:R:C110	R:R:W103	10.45	No	Yes	1	9	9
208	R:R:C187	R:R:W103	14.37	Yes	Yes	1	9	9
209	R:R:F105	R:R:P104	5.78	Yes	No	1	7	3
210	R:R:F105	R:R:L109	8.53	Yes	No	1	7	5
211	R:R:I107	R:R:W108	3.52	No	No	14	4	1
212	R:R:I107	R:R:L173	2.85	No	No	14	4	4
213	R:R:I107	R:R:T178	7.6	No	No	0	4	5
214	R:R:L173	R:R:W108	5.69	No	No	14	4	1
215	R:R:C110	R:R:R176	6.96	No	Yes	1	9	4
216	R:R:C110	R:R:C187	7.28	No	Yes	1	9	9
217	R:R:F115	R:R:K111	6.2	No	No	0	6	7
218	R:R:K111	R:R:L173	4.23	No	No	0	7	4
219	R:R:P171	R:R:S114	3.56	No	No	0	8	5
220	R:R:R176	R:R:S114	10.54	Yes	No	1	4	5
221	R:R:N120	R:R:T116	4.39	No	No	0	8	5
222	R:R:L119	R:R:W162	5.69	No	No	0	5	9
223	R:R:M121	R:R:W259	5.82	No	Yes	0	7	8
224	R:R:F122	R:R:I168	6.28	No	No	0	6	5
225	R:R:F122	R:R:K210	4.96	No	No	0	6	6
226	R:R:A123	R:R:F127	2.77	Yes	Yes	5	6	7
227	R:R:A123	R:R:W162	5.19	Yes	No	5	6	9
228	R:R:P218	R:R:V125	3.53	No	No	0	9	7
229	R:R:F126	R:R:I161	7.54	No	No	0	5	7
230	R:R:F126	R:R:L164	6.09	No	No	0	5	4
231	R:R:F127	R:R:I158	3.77	Yes	Yes	5	7	7
232	R:R:F127	R:R:I161	7.54	Yes	No	0	7	7
233	R:R:F127	R:R:W162	7.02	Yes	No	5	7	9
234	R:R:L128	R:R:N300	4.12	No	No	13	9	9
235	R:R:L128	R:R:Y304	8.21	No	No	13	9	9
236	R:R:P218	R:R:T129	6.99	No	No	0	9	7
237	R:R:T129	R:R:T221	4.71	No	No	0	7	6
238	R:R:M222	R:R:T129	3.01	No	No	0	8	7
239	R:R:M222	R:R:S132	4.6	No	No	0	8	9
240	R:R:S132	R:R:Y226	11.45	No	No	0	9	9
241	R:R:I137	R:R:L133	4.28	No	No	0	5	6
242	R:R:D134	R:R:R149	11.91	No	Yes	0	8	7
243	R:R:H135	R:R:L139	5.14	No	No	0	9	8
244	R:R:I140	R:R:Y136	6.04	Yes	No	0	7	7
245	R:R:C225	R:R:Y136	6.72	No	No	0	6	7
246	R:R:C228	R:R:Y136	4.03	No	No	0	4	7
247	R:R:H141	R:R:I137	2.65	No	No	0	6	5
248	R:R:I137	R:R:S145	3.1	No	No	0	5	6
249	R:R:H138	R:R:R149	4.51	No	Yes	0	8	7
250	R:R:L139	R:R:L229	6.92	No	No	0	8	7
251	R:R:H141	R:R:I140	7.95	No	Yes	0	6	7
252	R:R:I140	R:R:L229	2.85	Yes	No	0	7	7
253	R:R:I140	R:R:K234	2.91	Yes	No	0	7	5
254	R:R:H141	R:R:L144	14.14	No	No	0	6	5
255	R:R:K234	R:R:P142	3.35	No	No	0	5	8
256	R:R:R149	R:R:S145	2.64	Yes	No	0	7	6
257	R:R:K152	R:R:T150	7.51	No	No	0	5	6
258	R:R:N153	R:R:T150	4.39	No	No	0	4	6
259	R:R:L151	R:R:S154	3	No	Yes	0	3	7
260	R:R:L155	R:R:S154	3	No	Yes	0	4	7
261	R:R:L163	R:R:L167	2.77	No	No	0	4	4
262	R:R:L167	R:R:S166	3	No	No	0	4	4
263	R:R:I168	R:R:I213	4.42	No	No	0	5	4
264	R:R:G170	R:R:P171	4.06	No	No	0	4	8
265	R:R:H194	R:R:Y174	6.53	No	No	0	3	5
266	R:R:F175	R:R:F191	5.36	No	Yes	0	4	5
267	R:R:F175	R:R:R202	6.41	No	No	0	4	1
268	R:R:C187	R:R:R176	2.79	Yes	Yes	1	9	4
269	R:R:N189	R:R:R176	14.46	No	Yes	1	4	4
270	R:R:D177	R:R:N190	5.39	No	Yes	0	5	3
271	R:R:D177	R:R:H194	3.78	No	No	0	5	3
272	R:R:C187	R:R:T178	5.07	Yes	No	0	9	5
273	R:R:V179	R:R:Y188	8.83	No	No	3	1	3
274	R:R:E180	R:R:T185	2.82	No	No	0	1	4
275	R:R:F181	R:R:N182	15.71	No	No	0	4	3
276	R:R:N190	R:R:Y188	10.47	Yes	No	3	3	3
277	R:R:F191	R:R:N189	7.25	Yes	No	0	5	4
278	R:R:N190	R:R:Q192	7.92	Yes	Yes	3	3	4
279	R:R:K193	R:R:N190	5.6	Yes	Yes	3	2	3
280	R:R:F191	R:R:H203	16.97	Yes	Yes	0	5	4
281	R:R:K193	R:R:Q192	10.85	Yes	Yes	3	2	4
282	R:R:D195	R:R:P196	9.66	No	No	0	2	1
283	R:R:D195	R:R:D197	9.31	No	No	15	2	4
284	R:R:D195	R:R:L198	6.79	No	Yes	15	2	4
285	R:R:D197	R:R:L198	6.79	No	Yes	15	4	4
286	R:R:I201	R:R:L198	2.85	No	Yes	0	1	4
287	R:R:L198	R:R:R202	3.64	Yes	No	0	4	1
288	R:R:H204	R:R:L200	6.43	No	No	0	4	2
289	R:R:H203	R:R:T207	2.74	Yes	No	0	4	5
290	R:R:E269	R:R:H203	4.92	No	Yes	0	4	4
291	R:R:I267	R:R:W208	3.52	No	No	0	5	4
292	R:R:I213	R:R:V209	3.07	No	No	0	4	2
293	R:R:K210	R:R:S266	3.06	No	No	0	6	5
294	R:R:F211	R:R:Y215	5.16	No	Yes	9	6	8
295	R:R:F211	R:R:H263	6.79	No	Yes	9	6	8
296	R:R:I212	R:R:L216	7.14	No	No	0	5	4
297	R:R:L219	R:R:Y215	4.69	No	Yes	0	6	8
298	R:R:W259	R:R:Y215	2.89	Yes	Yes	9	8	8
299	R:R:T260	R:R:Y215	8.74	Yes	Yes	0	5	8
300	R:R:H263	R:R:Y215	21.78	Yes	Yes	9	8	8
301	R:R:F255	R:R:L219	3.65	No	No	0	9	6
302	R:R:I224	R:R:L220	2.85	No	No	0	4	4
303	R:R:F255	R:R:M222	12.44	No	No	0	9	8
304	R:R:I224	R:R:S223	3.1	No	No	0	4	3
305	R:R:I248	R:R:Y226	10.88	No	No	0	7	9
306	R:R:V252	R:R:Y226	5.05	No	No	0	7	9
307	R:R:F231	R:R:L227	9.74	No	No	0	3	3
308	R:R:H244	R:R:L229	3.86	No	No	0	7	7
309	R:R:H244	R:R:I230	6.63	No	Yes	16	7	4
310	R:R:F245	R:R:I230	5.02	No	Yes	0	6	4
311	R:R:I230	R:R:I248	8.83	Yes	No	16	4	7
312	R:R:L239	R:R:V233	4.47	No	No	0	3	8
313	R:R:K234	R:R:R236	6.19	No	No	0	5	5
314	R:R:I238	R:R:S237	3.1	No	No	0	4	4
315	R:R:R243	R:R:T247	14.23	No	No	0	7	7
316	R:R:R243	R:R:S308	3.95	No	No	0	7	8
317	R:R:K309	R:R:R243	4.95	No	No	0	6	7
318	R:R:H244	R:R:I248	6.63	No	No	16	7	7
319	R:R:F245	R:R:W246	5.01	No	No	0	6	6
320	R:R:F245	R:R:L249	3.65	No	No	0	6	4
321	R:R:L303	R:R:V250	2.98	Yes	No	0	8	6
322	R:R:L303	R:R:V251	5.96	Yes	No	0	8	7
323	R:R:V251	R:R:Y304	5.05	No	No	0	7	9
324	R:R:F255	R:R:W259	7.02	No	Yes	0	9	8
325	R:R:T260	R:R:V256	3.17	Yes	No	0	5	5
326	R:R:C258	R:R:N296	3.15	No	Yes	0	7	9
327	R:R:H263	R:R:W259	3.17	Yes	Yes	9	8	8
328	R:R:A293	R:R:W259	5.19	No	Yes	0	8	8
329	R:R:N296	R:R:W259	18.08	Yes	Yes	0	9	8
330	R:R:P261	R:R:T260	3.5	No	Yes	0	9	5
331	R:R:L264	R:R:T260	4.42	No	Yes	0	5	5
332	R:R:P261	R:R:S289	5.34	No	No	0	9	7
333	R:R:H263	R:R:Y262	3.27	Yes	No	0	8	6
334	R:R:S266	R:R:Y262	6.36	No	No	0	5	6
335	R:R:F265	R:R:I286	7.54	No	Yes	0	4	4
336	R:R:F265	R:R:S289	5.28	No	No	0	4	7
337	R:R:H279	R:R:W268	25.39	No	No	0	1	4
338	R:R:H273	R:R:L270	9	No	No	0	3	5
339	R:R:H273	R:R:H274	8.36	No	No	18	3	3
340	R:R:H273	R:R:S278	2.79	No	No	18	3	2
341	R:R:H274	R:R:S278	8.37	No	No	18	3	2
342	R:R:N275	R:R:S276	2.98	No	No	0	3	3
343	R:R:N275	R:R:S278	5.96	No	No	0	3	2
344	R:R:S276	R:R:Y277	5.09	No	Yes	0	3	1
345	R:R:V281	R:R:Y277	5.05	No	Yes	0	1	1
346	R:R:M282	R:R:Y277	4.79	No	Yes	0	4	1
347	R:R:H280	R:R:Q283	9.89	No	No	0	3	3
348	R:R:I286	R:R:V281	3.07	Yes	No	0	4	1
349	R:R:A284	R:R:P287	3.74	Yes	Yes	0	2	4
350	R:R:I286	R:R:P287	3.39	Yes	Yes	0	4	4
351	R:R:F294	R:R:T290	3.89	Yes	No	2	7	6
352	R:R:F294	R:R:G291	3.01	Yes	No	2	7	4
353	R:R:N296	R:R:S297	2.98	Yes	No	0	9	8
354	R:R:N296	R:R:N300	9.54	Yes	No	0	9	9
355	R:R:L299	R:R:L303	4.15	No	Yes	17	7	8
356	R:R:N300	R:R:Y304	5.81	No	No	13	9	9
357	R:R:I302	R:R:L306	9.99	No	No	0	6	6
358	R:R:L306	R:R:V305	4.47	No	No	0	6	6
359	R:R:F311	R:R:S308	6.61	Yes	No	0	8	8
360	R:R:F311	R:R:R314	7.48	Yes	No	8	8	6
361	R:R:H280	R:R:M282	2.63	No	No	0	3	4
362	R:R:H38	R:R:L42	2.57	Yes	No	0	5	5
363	L:L:I102	L:L:R113	2.51	Yes	Yes	0	0	0
364	R:R:F76	R:R:I131	2.51	No	No	0	8	8
365	R:R:F231	R:R:I230	2.51	No	Yes	0	3	4
366	L:L:Y149	R:R:T271	2.5	No	No	0	0	4
367	R:R:F311	R:R:K310	2.48	Yes	No	0	8	6
368	R:R:V281	R:R:W268	2.45	No	No	0	1	4
369	R:R:F181	R:R:L24	2.44	No	No	0	4	4
370	R:R:F191	R:R:L206	2.44	Yes	No	0	5	5
371	R:R:F217	R:R:L216	2.44	No	No	0	6	4
372	R:R:I60	R:R:W61	2.35	No	No	0	7	4
373	R:R:F315	R:R:Q312	2.34	No	No	0	5	8
374	L:L:E49	L:L:R27	2.33	No	No	0	0	0
375	R:R:N14	R:R:Y15	2.33	No	No	0	7	8
376	R:R:H148	R:R:R147	2.26	No	No	0	3	5
377	L:L:H116	R:R:Y22	2.18	No	No	0	0	5
378	R:R:G169	R:R:G170	2.11	No	No	0	7	4
379	L:L:F37	R:R:Y15	2.06	No	No	0	0	8
380	R:R:G52	R:R:P54	2.03	No	No	0	8	4
381	R:R:G55	R:R:P54	2.03	No	No	0	7	4
382	R:R:G214	R:R:P218	2.03	No	No	0	5	9
383	R:R:G285	R:R:P287	2.03	No	Yes	0	6	4
384	L:L:A62	L:L:G63	1.95	No	No	0	0	0
385	L:L:A62	L:L:G142	1.95	No	No	0	0	0
386	L:L:A141	L:L:G142	1.95	Yes	No	0	0	0
387	L:L:G29	L:L:V32	1.84	No	No	0	0	0
388	R:R:G64	R:R:T63	1.82	No	No	0	3	7
389	R:R:A123	R:R:A82	1.79	Yes	No	0	6	8
390	R:R:A123	R:R:A165	1.79	Yes	No	0	6	8
391	R:R:P142	R:R:V143	1.77	No	No	0	8	5
392	L:L:G29	L:L:I102	1.76	No	Yes	0	0	0
393	R:R:G55	R:R:I58	1.76	No	No	0	7	6
394	L:L:P59	L:L:T58	1.75	No	No	0	0	0
395	L:L:A155	L:L:S157	1.71	No	Yes	0	0	0
396	R:R:G291	R:R:L44	1.71	No	No	0	4	5
397	R:R:C258	R:R:V257	1.71	No	No	0	7	5
398	L:L:G152	L:L:Q153	1.64	No	Yes	0	0	0
399	L:L:G152	R:R:E269	1.64	No	No	0	0	4
400	R:R:C46	R:R:I94	1.64	No	No	0	5	6
401	R:R:C225	R:R:I224	1.64	No	No	0	6	4
402	R:R:V36	R:R:V37	1.6	No	No	0	3	3
403	R:R:V205	R:R:V209	1.6	No	No	0	3	2
404	R:R:V253	R:R:V257	1.6	No	No	0	5	5
405	R:R:G35	R:R:H38	1.59	No	Yes	0	3	5
406	L:L:A141	R:R:L28	1.58	Yes	No	4	0	2
407	R:R:A98	R:R:L42	1.58	No	No	0	4	5
408	R:R:A48	R:R:L295	1.58	No	No	0	6	5
409	R:R:A254	R:R:L299	1.58	No	No	17	7	7
410	R:R:A254	R:R:L303	1.58	No	Yes	17	7	8
411	R:R:I240	R:R:S242	1.55	No	No	0	5	5
412	L:L:H40	L:L:P41	1.53	No	No	0	0	0
413	R:R:I267	R:R:T207	1.52	No	No	0	5	5
414	R:R:I272	R:R:T271	1.52	No	No	0	2	4
415	R:R:F105	R:R:G106	1.51	Yes	No	0	7	7
416	L:L:G29	L:L:R28	1.5	No	No	0	0	0
417	R:R:L92	R:R:S95	1.5	Yes	No	0	6	4
418	R:R:L119	R:R:S166	1.5	No	No	0	5	4
419	R:R:L288	R:R:V40	1.49	No	No	0	5	6
420	R:R:L47	R:R:V43	1.49	No	No	0	4	5
421	R:R:N153	R:R:V157	1.48	No	No	0	4	6
422	R:R:I60	R:R:I81	1.47	No	No	0	7	5
423	R:R:I81	R:R:I85	1.47	No	No	0	5	6
424	R:R:I158	R:R:I159	1.47	Yes	No	0	7	3
425	R:R:I212	R:R:I213	1.47	No	No	0	5	4
426	R:R:K232	R:R:K235	1.44	No	No	0	5	4
427	L:L:C77	L:L:R78	1.39	No	No	0	0	0
428	R:R:L139	R:R:L239	1.38	No	No	0	8	3
429	R:R:I307	R:R:Q312	1.37	No	No	0	6	8
430	L:L:R67	L:L:V56	1.31	Yes	No	0	0	0
431	L:L:Q73	L:L:Q74	1.28	Yes	No	0	0	0
432	R:R:H184	R:R:N100	1.28	No	No	0	3	3
433	R:R:F231	R:R:K232	1.24	No	No	0	3	5
434	R:R:F160	R:R:L164	1.22	No	No	0	3	4
435	L:L:D81	L:L:W82	1.12	No	No	0	0	0
436	R:R:H38	R:R:W39	1.06	Yes	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Q26	7.955	4	10	0
2	L:L:E36	11.2525	4	11	0
3	L:L:F47	16.5925	4	0	0
4	L:L:F65	10.06	4	0	0
5	L:L:V66	4.4125	4	10	0
6	L:L:R67	2.9375	4	6	0
7	L:L:Q73	11.565	4	12	0
8	L:L:L99	5.808	5	6	0
9	L:L:C101	4.3575	4	6	0
10	L:L:I102	2.9875	4	0	0
11	L:L:R113	11.54	4	11	0
12	L:L:C135	4.634	5	6	0
13	L:L:R137	10.6725	4	3	0
14	L:L:A141	2.7775	4	4	0
15	L:L:F148	6.9725	4	4	0
16	L:L:F150	11.06	4	3	0
17	L:L:Q153	5.5075	4	0	0
18	L:L:F156	7.72	4	2	0
19	L:L:S157	7.084	5	1	0
20	R:R:H38	2.0375	4	0	5
21	R:R:Y45	5.89	5	2	8
22	R:R:I53	5.955	4	0	6
23	R:R:N56	6.89	4	7	9
24	R:R:F65	9.264	5	8	4
25	R:R:W75	5.53857	7	5	7
26	R:R:D83	8.4875	4	7	9
27	R:R:F84	6.3	4	0	7
28	R:R:F86	7.056	5	2	7
29	R:R:L87	4.5675	4	7	6
30	R:R:L92	4.878	5	1	6
31	R:R:Y93	5.31	4	2	6
32	R:R:H102	7.5375	4	1	5
33	R:R:W103	11.66	5	1	9
34	R:R:F105	7.102	5	1	7
35	R:R:A123	2.885	4	5	6
36	R:R:F127	6.80333	6	5	7
37	R:R:I140	4.9375	4	0	7
38	R:R:R149	5.745	4	0	7
39	R:R:S154	3.8375	4	0	7
40	R:R:I158	3.605	4	5	7
41	R:R:R176	8.794	5	1	4
42	R:R:C187	7.3775	4	1	9
43	R:R:N190	7.345	4	3	3
44	R:R:F191	8.005	4	0	5
45	R:R:Q192	8.4025	4	3	4
46	R:R:K193	7.754	5	3	2
47	R:R:L198	5.0175	4	15	4
48	R:R:H203	6.92	4	0	4
49	R:R:Y215	8.652	5	9	8
50	R:R:I230	5.7475	4	16	4
51	R:R:W259	7.02833	6	9	8
52	R:R:T260	4.9575	4	0	5
53	R:R:H263	8.7525	4	9	8
54	R:R:Y277	5.7175	4	0	1
55	R:R:A284	3.37	4	0	2
56	R:R:I286	4.755	4	0	4
57	R:R:P287	3.1725	4	0	4
58	R:R:F294	6.87	7	2	7
59	R:R:N296	8.4375	4	0	9
60	R:R:L303	3.6675	4	17	8
61	R:R:F311	6.958	5	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H116	L:L:L99	20.7849	9	No	Yes	0	0	0
2	L:L:H116	R:R:Y22	21.4002	2.18	No	No	0	0	5
3	R:R:L24	R:R:Y22	40.5373	9.38	No	No	0	4	5
4	R:R:F181	R:R:L24	39.9905	2.44	No	No	0	4	4
5	R:R:F181	R:R:N182	39.4415	15.71	No	No	0	4	3
6	R:R:E25	R:R:N182	38.8906	7.89	No	No	0	7	3
7	L:L:R113	R:R:E25	37.7824	9.3	Yes	No	0	0	7
8	L:L:I102	L:L:R113	10.6524	2.51	Yes	Yes	0	0	0
9	L:L:E36	L:L:R113	27.3863	29.08	Yes	Yes	11	0	0
10	L:L:E36	R:R:Y21	25.6389	4.49	Yes	No	0	0	3
11	L:L:F37	R:R:Y21	20.7818	8.25	No	No	0	0	3
12	L:L:F37	R:R:Y15	18.9265	2.06	No	No	0	0	8
13	R:R:N14	R:R:Y15	18.3028	2.33	No	No	0	7	8
14	L:L:W45	R:R:N14	15.7876	12.43	No	No	0	0	7
15	L:L:W45	R:R:F12	15.1536	10.02	No	No	0	0	3
16	L:L:K79	R:R:F12	14.5176	11.17	No	No	0	0	3
17	L:L:K79	L:L:R78	13.8794	3.71	No	No	0	0	0
18	L:L:C77	L:L:R78	10.6575	1.39	No	No	0	0	0
19	L:L:C77	L:L:C87	10.007	5.46	No	No	0	0	0
20	R:R:E180	R:R:Y22	57.8834	6.73	No	No	0	1	5
21	R:R:E180	R:R:T185	58.3576	2.82	No	No	0	1	4
22	R:R:H102	R:R:T185	58.8298	13.69	Yes	No	0	5	4
23	R:R:H102	R:R:P104	60.1247	7.63	Yes	No	1	5	3
24	R:R:F105	R:R:P104	61.1592	5.78	Yes	No	1	7	3
25	R:R:F105	R:R:W103	62.1896	16.04	Yes	Yes	1	7	9
26	R:R:W103	R:R:Y96	78.578	10.61	Yes	No	0	9	6
27	R:R:L186	R:R:Y96	21.5704	3.52	No	No	0	3	6
28	L:L:Q153	R:R:L186	21.0713	3.99	Yes	No	0	0	3
29	L:L:F150	L:L:Q153	13.2423	5.86	Yes	Yes	0	0	0
30	L:L:F154	L:L:Q153	15.5261	10.54	No	Yes	0	0	0
31	L:L:F154	R:R:I286	15.7793	5.02	No	Yes	0	0	4
32	R:R:I286	R:R:V281	11.5063	3.07	Yes	No	0	4	1
33	R:R:C110	R:R:W103	11.4773	10.45	No	Yes	1	9	9
34	R:R:C110	R:R:R176	10.9211	6.96	No	Yes	1	9	4
35	R:R:N189	R:R:R176	12.8719	14.46	No	Yes	1	4	4
36	R:R:F191	R:R:N189	12.3064	7.25	Yes	No	0	5	4
37	R:R:C187	R:R:W103	15.0883	14.37	Yes	Yes	1	9	9
38	R:R:C187	R:R:R176	11.195	2.79	Yes	Yes	1	9	4
39	R:R:Y93	R:R:Y96	83.2878	3.97	Yes	No	0	6	6
40	R:R:F294	R:R:Y93	78.9578	3.09	Yes	Yes	2	7	6
41	L:L:F156	R:R:F294	37.91	4.29	Yes	Yes	2	0	7
42	R:R:F294	R:R:F86	42.1435	11.79	Yes	Yes	2	7	7
43	L:L:F156	R:R:Y262	38.1829	10.32	Yes	No	0	0	6
44	R:R:I286	R:R:P287	10.7406	3.39	Yes	Yes	0	4	4
45	R:R:F86	R:R:S297	41.0883	3.96	Yes	No	0	7	8
46	R:R:H263	R:R:Y262	38.0117	3.27	Yes	No	0	8	6
47	R:R:H263	R:R:W259	36.558	3.17	Yes	Yes	9	8	8
48	R:R:F255	R:R:W259	88.3183	7.02	No	Yes	0	9	8
49	R:R:F255	R:R:M222	100	12.44	No	No	0	9	8
50	R:R:M222	R:R:S132	97.2731	4.6	No	No	0	8	9
51	R:R:S132	R:R:Y226	96.8103	11.45	No	No	0	9	9
52	R:R:I248	R:R:Y226	95.8785	10.88	No	No	0	7	9
53	R:R:H244	R:R:I248	90.3874	6.63	No	No	16	7	7
54	R:R:H244	R:R:L229	91.095	3.86	No	No	0	7	7
55	R:R:I140	R:R:L229	88.6254	2.85	Yes	No	0	7	7
56	R:R:H141	R:R:I140	83.0098	7.95	No	Yes	0	6	7
57	R:R:H141	R:R:I137	81.9618	2.65	No	No	0	6	5
58	R:R:I137	R:R:S145	80.9054	3.1	No	No	0	5	6
59	R:R:R149	R:R:S145	80.3742	2.64	Yes	No	0	7	6
60	R:R:R149	R:R:V71	40.9814	3.92	Yes	No	0	7	6
61	R:R:V71	R:R:W75	37.9723	8.58	No	Yes	0	6	7
62	R:R:I131	R:R:W75	45.962	7.05	No	Yes	0	8	7
63	R:R:F76	R:R:I131	44.6422	2.51	No	No	0	8	8
64	R:R:N296	R:R:S297	42.2919	2.98	Yes	No	0	9	8
65	R:R:N296	R:R:W259	42.2255	18.08	Yes	Yes	0	9	8
66	R:R:D134	R:R:R149	38.3334	11.91	No	Yes	0	8	7
67	R:R:D134	R:R:W75	37.7305	3.35	No	Yes	0	8	7
68	R:R:F311	R:R:F76	38.02	3.22	Yes	No	0	8	8
69	R:R:F311	R:R:F65	20.4663	15	Yes	Yes	8	8	4
70	R:R:K66	R:R:K69	13.7009	15.8	No	No	0	5	7
71	R:R:F127	R:R:W75	19.1745	4.01	Yes	Yes	5	7	7
72	R:R:L219	R:R:Y215	12.3499	4.69	No	Yes	0	6	8
73	R:R:T260	R:R:Y215	25.8776	8.74	Yes	Yes	0	5	8
74	R:R:F265	R:R:I286	23.9206	7.54	No	Yes	0	4	4
75	R:R:F265	R:R:S289	24.0638	5.28	No	No	0	4	7
76	R:R:P261	R:R:S289	24.2464	5.34	No	No	0	9	7
77	R:R:P261	R:R:T260	24.4332	3.5	No	Yes	0	9	5
78	R:R:F255	R:R:L219	12.2213	3.65	No	No	0	9	6
79	R:R:W259	R:R:Y215	13.3803	2.89	Yes	Yes	9	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E36	R:R:Y21	4.49	11	Yes	No	0	3	0	1
L:L:E36	R:R:S23	4.31	11	Yes	No	0	5	0	1
L:L:F37	R:R:L19	4.87	0	No	No	0	3	0	1
L:L:F37	R:R:Y21	8.25	0	No	No	0	3	0	1
L:L:P41	R:R:N14	9.77	0	No	No	0	7	0	1
L:L:W45	R:R:F12	10.02	0	No	No	0	3	0	1
L:L:W45	R:R:N14	12.43	0	No	No	0	7	0	1
L:L:K71	R:R:D18	4.15	0	No	No	0	6	0	1
L:L:L72	R:R:L19	4.15	0	No	No	0	3	0	1
L:L:Q74	R:R:Y17	4.51	0	No	No	0	4	0	1
L:L:T75	R:R:E13	11.29	0	No	No	0	3	0	1
L:L:K79	R:R:F12	11.17	0	No	No	0	3	0	1
L:L:L111	R:R:D27	16.29	4	No	No	0	4	0	1
L:L:L111	R:R:L28	13.84	4	No	No	0	2	0	1
L:L:G112	R:R:S26	3.71	0	No	No	0	4	0	1
L:L:R113	R:R:S23	5.27	11	Yes	No	0	5	0	1
L:L:R113	R:R:E25	9.3	11	Yes	No	0	7	0	1
L:L:C117	R:R:Y21	4.03	0	No	No	0	3	0	1
L:L:Q134	R:R:V179	4.3	3	No	No	0	1	0	1
L:L:Q134	R:R:K193	6.78	3	No	Yes	0	2	0	1
L:L:L136	R:R:K193	5.64	0	No	Yes	0	2	0	1
L:L:R137	R:R:Q192	11.68	3	Yes	Yes	0	4	0	1
L:L:R137	R:R:K193	9.9	3	Yes	Yes	0	2	0	1
L:L:F148	R:R:S26	9.25	4	Yes	No	0	4	0	1
L:L:Y149	R:R:E269	8.98	0	No	No	0	4	0	1
L:L:Y149	R:R:Y277	7.94	0	No	Yes	0	1	0	1
L:L:F150	R:R:V179	3.93	3	Yes	No	0	1	0	1
L:L:F150	R:R:Y188	22.69	3	Yes	No	0	3	0	1
L:L:P151	R:R:Q192	3.16	0	No	Yes	0	4	0	1
L:L:P151	R:R:H203	3.05	0	No	Yes	0	4	0	1
L:L:Q153	R:R:L186	3.99	0	Yes	No	0	3	0	1
L:L:F154	R:R:F101	9.65	0	No	No	0	4	0	1
L:L:F154	R:R:I286	5.02	0	No	Yes	0	4	0	1
L:L:F156	R:R:F86	10.72	2	Yes	Yes	0	7	0	1
L:L:F156	R:R:A117	5.55	2	Yes	No	0	6	0	1
L:L:F156	R:R:Y262	10.32	2	Yes	No	0	6	0	1
L:L:F156	R:R:F294	4.29	2	Yes	Yes	0	7	0	1
L:L:S157	R:R:S114	9.77	1	Yes	No	0	5	0	1
L:L:S157	R:R:Q118	5.78	1	Yes	No	0	5	0	1
L:L:S157	R:R:R176	9.22	1	Yes	Yes	0	4	0	1
L:L:S157	R:R:N189	8.94	1	Yes	No	0	4	0	1
R:R:L24	R:R:Y22	9.38	0	No	No	4	5	2	1
R:R:E180	R:R:Y22	6.73	0	No	No	1	5	2	1
R:R:E25	R:R:N182	7.89	0	No	No	7	3	1	2
R:R:E25	R:R:N183	6.57	0	No	No	7	5	1	2
R:R:D27	R:R:L28	12.21	4	No	No	4	2	1	1
R:R:L90	R:R:Y45	4.69	2	No	Yes	7	8	2	2
R:R:Y45	R:R:Y93	7.94	2	Yes	Yes	8	6	2	2
R:R:G291	R:R:Y45	5.79	2	No	Yes	4	8	2	2
R:R:F294	R:R:Y45	6.19	2	Yes	Yes	7	8	1	2
R:R:A117	R:R:F86	2.77	2	No	Yes	6	7	1	1
R:R:F86	R:R:N120	6.04	2	Yes	No	7	8	1	2
R:R:F294	R:R:F86	11.79	2	Yes	Yes	7	7	1	1
R:R:F86	R:R:S297	3.96	2	Yes	No	7	8	1	2
R:R:F294	R:R:L90	15.83	2	Yes	No	7	7	1	2
R:R:Y93	R:R:Y96	3.97	2	Yes	No	6	6	2	2
R:R:T290	R:R:Y93	6.24	2	No	Yes	6	6	2	2
R:R:F294	R:R:Y93	3.09	2	Yes	Yes	7	6	1	2
R:R:L186	R:R:Y96	3.52	0	No	No	3	6	1	2
R:R:C110	R:R:R176	6.96	1	No	Yes	9	4	2	1
R:R:C110	R:R:C187	7.28	1	No	Yes	9	9	2	2
R:R:P171	R:R:S114	3.56	0	No	No	8	5	2	1
R:R:R176	R:R:S114	10.54	1	Yes	No	4	5	1	1
R:R:C187	R:R:R176	2.79	1	Yes	Yes	9	4	2	1
R:R:N189	R:R:R176	14.46	1	No	Yes	4	4	1	1
R:R:V179	R:R:Y188	8.83	3	No	No	1	3	1	1
R:R:N190	R:R:Y188	10.47	3	Yes	No	3	3	2	1
R:R:F191	R:R:N189	7.25	0	Yes	No	5	4	2	1
R:R:N190	R:R:Q192	7.92	3	Yes	Yes	3	4	2	1
R:R:K193	R:R:N190	5.6	3	Yes	Yes	2	3	1	2
R:R:F191	R:R:H203	16.97	0	Yes	Yes	5	4	2	1
R:R:K193	R:R:Q192	10.85	3	Yes	Yes	2	4	1	1
R:R:H203	R:R:T207	2.74	0	Yes	No	4	5	1	2
R:R:E269	R:R:H203	4.92	0	No	Yes	4	4	1	1
R:R:H263	R:R:Y262	3.27	9	Yes	No	8	6	2	1
R:R:S266	R:R:Y262	6.36	0	No	No	5	6	2	1
R:R:F265	R:R:I286	7.54	0	No	Yes	4	4	2	1
R:R:S276	R:R:Y277	5.09	0	No	Yes	3	1	2	1
R:R:V281	R:R:Y277	5.05	0	No	Yes	1	1	2	1
R:R:M282	R:R:Y277	4.79	0	No	Yes	4	1	2	1
R:R:I286	R:R:V281	3.07	0	Yes	No	4	1	1	2
R:R:I286	R:R:P287	3.39	0	Yes	Yes	4	4	1	2
R:R:F294	R:R:T290	3.89	2	Yes	No	7	6	1	2
R:R:F294	R:R:G291	3.01	2	Yes	No	7	4	1	2
L:L:Y149	R:R:T271	2.5	0	No	No	0	4	0	1
R:R:N14	R:R:Y15	2.33	0	No	No	7	8	1	1
L:L:H116	R:R:Y22	2.18	0	No	No	0	5	0	1
L:L:F37	R:R:Y15	2.06	0	No	No	0	8	0	1
L:L:G152	R:R:E269	1.64	0	No	No	0	4	0	1
L:L:A141	R:R:L28	1.58	4	Yes	No	0	2	0	1
R:R:I272	R:R:T271	1.52	0	No	No	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L3Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	386
Number of Links	436
Number of Hubs	61
Number of Links mediated by Hubs	215
Number of Communities	18
Number of Nodes involved in Communities	86
Number of Links involved in Communities	111

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	155314
Length Of Smallest Path	3
Average Path Length	24.8515
Length of Longest Path	58
Minimum Path Strength	1.325
Average Path Strength	6.74168
Maximum Path Strength	26.355
Minimum Path Correlation	0.7
Average Path Correlation	0.960483
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	47.0593
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.3045
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • signaling receptor binding • cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • response to stimulus • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of biological process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • response to chemical • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • biological regulation • positive regulation of leukocyte migration • regulation of chemotaxis • cellular response to chemical stimulus • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular process • leukocyte chemotaxis • biological process involved in interspecies interaction between organisms • antifungal innate immune response • immune response • response to other organism • defense response • defense response to symbiont • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • innate immune response • response to external biotic stimulus • response to fungus • humoral immune response • antimicrobial humoral response • antifungal humoral response • developmental process • cellular developmental process • cell differentiation • cellular response to nitrogen compound • signaling • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cell communication • cellular response to endogenous stimulus • response to hormone • signal transduction • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • multicellular organismal process • digestive system development • tube development • animal organ development • embryo development • digestive tract development • multicellular organism development • anatomical structure development • embryonic organ development • embryonic digestive tract development • system development • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • metabolic process • regulation of phosphorylation • macromolecule metabolic process • regulation of metabolic process • inflammatory response • lipid catabolic process • catabolic process • regulation of lipid metabolic process • regulation of catabolic process • regulation of lipid catabolic process • lipid metabolic process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • endomembrane system • platelet dense granule lumen • cytoplasmic vesicle • platelet dense granule • secretory granule • secretory vesicle • cytoplasm • vesicle • extracellular region • extracellular matrix • external encapsulating structure • collagen-containing extracellular matrix • extracellular space • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell division • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>9L3Y_nogp_Chain_R F E N Y S Y D L D Y Y S L E S D L G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N F Q K H D P D L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S I L I S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F Q A R F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Retinoic acid receptor responder protein 2	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Retinoic acid receptor responder protein 2	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	To be published
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	To be published
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	2.9	2024-08-21	To be published
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		2.9	2024-08-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9L3Y_nogp.zip

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