psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L22	L:L:Q26	3.99	No	No	6	6	8
2	L:L:L22	L:L:R27	10.93	No	No	6	6	4
3	L:L:E24	L:L:T23	2.82	No	No	0	3	6
4	L:L:Q26	L:L:T23	14.17	No	No	0	8	6
5	L:L:A25	L:L:D57	3.09	No	No	0	3	6
6	L:L:Q26	L:L:R27	17.52	No	No	6	8	4
7	L:L:L30	L:L:R27	3.64	No	No	0	8	4
8	L:L:Q31	L:L:R28	9.35	No	Yes	0	4	7
9	L:L:L104	L:L:R28	7.29	No	Yes	7	9	7
10	L:L:D108	L:L:R28	13.1	No	Yes	0	4	7
11	L:L:R28	L:L:V110	3.92	Yes	No	7	7	8
12	L:L:L30	L:L:L68	4.15	No	Yes	0	8	8
13	L:L:Q31	L:L:V32	5.73	No	No	0	4	6
14	L:L:V110	L:L:V32	4.81	No	No	0	8	6
15	L:L:A33	L:L:F70	2.77	No	Yes	0	7	6
16	L:L:E49	L:L:L34	9.28	No	No	1	6	8
17	L:L:L34	L:L:L72	5.54	No	No	1	8	8
18	L:L:E35	L:L:E36	5.07	No	No	0	6	5
19	L:L:E35	L:L:K39	10.8	No	No	0	6	4
20	L:L:E35	L:L:W82	5.45	No	No	0	6	5
21	L:L:E36	L:L:R113	15.12	No	Yes	0	5	7
22	L:L:F37	L:L:H40	3.39	No	No	0	8	8
23	L:L:F37	R:R:Y21	10.32	No	No	0	8	3
24	L:L:A46	L:L:H38	8.78	No	No	0	7	9
25	L:L:H38	L:L:W82	16.93	No	No	0	9	5
26	L:L:A46	L:L:H40	2.93	No	No	0	7	8
27	L:L:H40	L:L:K79	6.55	No	No	0	8	9
28	L:L:P41	L:L:P42	7.79	No	No	0	6	5
29	L:L:P42	L:L:V43	3.53	No	No	9	5	8
30	L:L:P42	R:R:D18	8.05	No	No	9	5	6
31	L:L:V43	R:R:D18	5.84	No	No	9	8	6
32	L:L:Q44	L:L:R78	8.18	No	No	0	5	2
33	L:L:Q44	R:R:Y15	5.64	No	Yes	0	5	8
34	L:L:Q74	L:L:W45	8.76	Yes	No	1	9	4
35	L:L:W45	R:R:Y15	9.65	No	Yes	1	4	8
36	L:L:F47	L:L:L72	6.09	Yes	No	1	9	8
37	L:L:F47	L:L:Q74	8.2	Yes	Yes	1	9	9
38	L:L:F47	L:L:R94	7.48	Yes	No	1	9	8
39	L:L:F47	L:L:R96	5.34	Yes	No	0	9	7
40	L:L:Q48	L:L:T75	9.92	No	Yes	0	4	9
41	L:L:Q48	L:L:V89	5.73	No	No	0	4	4
42	L:L:E49	L:L:F70	16.32	No	Yes	0	6	6
43	L:L:E49	L:L:L72	13.25	No	No	1	6	8
44	L:L:S51	L:L:T50	3.2	No	No	5	5	7
45	L:L:K71	L:L:T50	10.51	Yes	No	5	4	7
46	L:L:Q73	L:L:T50	2.83	Yes	No	5	7	7
47	L:L:K71	L:L:S51	4.59	Yes	No	5	4	5
48	L:L:E53	L:L:K71	4.05	No	Yes	0	5	4
49	L:L:R67	L:L:S54	7.91	No	No	0	6	4
50	L:L:R67	L:L:V56	7.85	No	No	0	6	1
51	L:L:D57	L:L:I64	5.6	No	No	0	6	8
52	L:L:P59	L:L:T58	3.5	No	No	0	2	3
53	L:L:F60	L:L:T58	3.89	Yes	No	0	4	3
54	L:L:F60	L:L:P61	2.89	Yes	No	0	4	4
55	L:L:G63	L:L:I64	3.53	No	No	0	9	8
56	L:L:C101	L:L:F65	4.19	No	Yes	10	9	8
57	L:L:F65	L:L:K103	3.72	Yes	No	0	8	9
58	L:L:C135	L:L:F65	2.79	No	Yes	10	9	8
59	L:L:F65	L:L:Q139	14.05	Yes	No	0	8	5
60	L:L:L68	L:L:V66	7.45	Yes	No	0	8	9
61	L:L:E69	L:L:R67	5.82	No	No	0	7	6
62	L:L:F70	L:L:L68	7.31	Yes	Yes	0	6	8
63	L:L:E69	L:L:L99	7.95	No	No	0	7	7
64	L:L:C98	L:L:F70	2.79	No	Yes	0	8	6
65	L:L:A100	L:L:F70	2.77	No	Yes	0	8	6
66	L:L:K71	L:L:Q73	6.78	Yes	Yes	5	4	7
67	L:L:K71	L:L:K95	4.31	Yes	No	5	4	6
68	L:L:Q73	L:L:V89	2.87	Yes	No	0	7	4
69	L:L:K95	L:L:Q73	9.49	No	Yes	5	6	7
70	L:L:G93	L:L:Q74	4.93	No	Yes	0	6	9
71	L:L:Q74	L:L:R94	9.35	Yes	No	1	9	8
72	L:L:Q74	R:R:Y15	7.89	Yes	Yes	1	9	8
73	L:L:C77	L:L:T75	3.38	No	Yes	3	9	9
74	L:L:C87	L:L:T75	8.45	No	Yes	3	9	9
75	L:L:C77	L:L:D81	7.78	No	No	3	9	5
76	L:L:C77	L:L:C87	7.28	No	No	3	9	9
77	L:L:K79	L:L:R78	9.9	No	No	8	9	2
78	L:L:R78	L:L:R80	8.53	No	No	8	2	5
79	L:L:K79	L:L:R80	6.19	No	No	8	9	5
80	L:L:D81	L:L:K84	16.59	No	No	3	5	4
81	L:L:D81	L:L:E86	5.2	No	No	3	5	6
82	L:L:K83	L:L:W82	16.24	No	No	0	4	5
83	L:L:K84	L:L:P85	3.35	No	No	0	4	4
84	L:L:E86	L:L:K84	8.1	No	No	3	6	4
85	L:L:R94	R:R:Y17	6.17	No	No	0	8	4
86	L:L:I119	L:L:R96	7.52	No	No	0	4	7
87	L:L:E120	L:L:K97	9.45	No	No	0	4	4
88	L:L:C117	L:L:C98	7.28	No	No	0	9	8
89	L:L:L99	L:L:Q131	5.32	No	Yes	0	7	5
90	L:L:A100	L:L:I102	3.25	No	No	0	8	5
91	L:L:C101	L:L:C135	7.28	No	No	10	9	9
92	L:L:C101	L:L:V138	3.42	No	No	0	9	8
93	L:L:I102	L:L:R113	5.01	No	Yes	0	5	7
94	L:L:K103	L:L:L111	2.82	No	No	0	9	8
95	L:L:A141	L:L:K103	3.21	No	No	0	6	9
96	L:L:L104	L:L:V110	2.98	No	No	7	9	8
97	L:L:E107	L:L:K109	9.45	No	No	0	1	4
98	L:L:G112	L:L:L111	3.42	No	No	0	5	8
99	L:L:L111	R:R:L28	4.15	No	No	0	8	2
100	L:L:G112	R:R:S26	3.71	No	No	0	5	4
101	L:L:R113	R:R:S23	5.27	Yes	No	0	7	5
102	L:L:R113	R:R:E25	16.28	Yes	No	0	7	7
103	L:L:L114	R:R:Y22	3.52	No	Yes	4	7	5
104	L:L:L114	R:R:L24	4.15	No	No	4	7	4
105	L:L:V115	R:R:Y21	6.31	No	No	0	3	3
106	L:L:H116	L:L:P118	7.63	Yes	No	0	8	7
107	L:L:H116	L:L:H130	7.17	Yes	No	4	8	4
108	L:L:H116	R:R:Y22	4.36	Yes	Yes	4	8	5
109	L:L:P118	L:L:Q122	4.74	No	No	0	7	6
110	L:L:I119	L:L:T121	6.08	No	No	0	4	5
111	L:L:I119	R:R:Y17	8.46	No	No	0	4	4
112	L:L:A127	L:L:H130	2.93	No	No	0	3	4
113	L:L:E128	L:L:Q131	6.37	No	Yes	0	3	5
114	L:L:E129	R:R:H194	8.62	No	No	0	3	3
115	L:L:T133	R:R:Q192	5.67	No	No	0	4	4
116	L:L:Q134	L:L:R137	3.5	No	No	0	6	5
117	L:L:Q134	R:R:Y22	3.38	No	Yes	0	6	5
118	L:L:F148	L:L:R137	4.28	Yes	No	0	1	5
119	L:L:F150	L:L:R137	10.69	Yes	No	0	4	5
120	L:L:A141	L:L:S147	3.42	No	No	0	6	3
121	L:L:D144	L:L:P145	6.44	No	No	11	4	1
122	L:L:D144	L:L:H146	7.56	No	Yes	11	4	5
123	L:L:D144	L:L:S147	2.94	No	No	0	4	3
124	L:L:H146	L:L:P145	7.63	Yes	No	11	5	1
125	L:L:H146	R:R:I272	10.61	Yes	No	0	5	2
126	L:L:H146	R:R:H279	3.58	Yes	No	0	5	1
127	L:L:F148	R:R:L24	6.09	Yes	No	0	1	4
128	L:L:F148	R:R:S26	6.61	Yes	No	0	1	4
129	L:L:F148	R:R:E29	4.66	Yes	No	0	1	6
130	L:L:F148	R:R:F181	9.65	Yes	No	0	1	4
131	L:L:Q153	L:L:Y149	3.38	Yes	Yes	2	6	5
132	L:L:F154	L:L:Y149	5.16	Yes	Yes	2	6	5
133	L:L:Y149	R:R:E269	13.47	Yes	No	0	5	4
134	L:L:Y149	R:R:I272	4.84	Yes	No	0	5	2
135	L:L:Y149	R:R:H279	14.16	Yes	No	0	5	1
136	L:L:F150	L:L:Q153	8.2	Yes	Yes	2	4	6
137	L:L:F150	R:R:V179	9.18	Yes	No	2	4	1
138	L:L:F150	R:R:F181	4.29	Yes	No	0	4	4
139	L:L:F150	R:R:Y188	10.32	Yes	Yes	2	4	3
140	L:L:P151	R:R:F191	4.33	No	Yes	0	9	5
141	L:L:F154	L:L:Q153	12.88	Yes	Yes	2	6	6
142	L:L:Q153	R:R:L186	5.32	Yes	No	0	6	3
143	L:L:F154	R:R:F101	17.15	Yes	Yes	0	6	4
144	L:L:F154	R:R:Q283	7.03	Yes	No	0	6	3
145	L:L:F154	R:R:I286	3.77	Yes	No	0	6	4
146	L:L:F156	R:R:F86	3.22	No	Yes	12	9	7
147	L:L:F156	R:R:A117	2.77	No	No	12	9	6
148	L:L:F156	R:R:T290	9.08	No	No	0	9	6
149	L:L:S157	R:R:Q118	11.55	No	Yes	0	5	5
150	R:R:N14	R:R:Y15	22.1	No	Yes	0	7	8
151	R:R:S23	R:R:Y21	3.82	No	No	0	5	3
152	R:R:L24	R:R:Y22	7.03	No	Yes	4	4	5
153	R:R:E180	R:R:Y22	3.37	No	Yes	0	1	5
154	R:R:E25	R:R:N182	5.26	No	No	0	7	3
155	R:R:K31	R:R:N182	5.6	No	No	0	1	3
156	R:R:H184	R:R:K31	7.86	No	No	0	3	1
157	R:R:N100	R:R:V32	8.87	No	Yes	0	3	3
158	R:R:F101	R:R:V32	5.24	Yes	Yes	0	4	3
159	R:R:H184	R:R:V32	2.77	No	Yes	0	3	3
160	R:R:Q283	R:R:V32	5.73	No	Yes	0	3	3
161	R:R:L34	R:R:W39	10.25	No	No	0	4	3
162	R:R:L34	R:R:N100	4.12	No	No	0	4	3
163	R:R:G35	R:R:W39	2.81	No	No	0	3	3
164	R:R:V36	R:R:W39	3.68	No	No	0	3	3
165	R:R:A284	R:R:V37	5.09	No	No	0	2	3
166	R:R:L288	R:R:V37	5.96	No	No	0	5	3
167	R:R:F101	R:R:H38	6.79	Yes	No	0	4	5
168	R:R:L288	R:R:V40	2.98	No	No	0	5	6
169	R:R:S41	R:R:Y45	5.09	No	Yes	0	5	8
170	R:R:P287	R:R:S41	3.56	No	No	0	4	5
171	R:R:L288	R:R:S41	3	No	No	0	5	5
172	R:R:L295	R:R:L44	4.15	No	No	0	5	5
173	R:R:Y45	R:R:Y93	7.94	Yes	No	0	8	6
174	R:R:I94	R:R:Y45	4.84	No	Yes	0	6	8
175	R:R:V97	R:R:Y45	3.79	No	Yes	0	5	8
176	R:R:G291	R:R:Y45	2.9	No	Yes	0	4	8
177	R:R:F49	R:R:I53	6.28	No	No	0	7	6
178	R:R:C298	R:R:G52	3.92	Yes	No	0	7	8
179	R:R:I53	R:R:P54	5.08	No	No	0	6	4
180	R:R:D83	R:R:N56	4.04	Yes	No	0	9	9
181	R:R:F84	R:R:N56	4.83	No	No	0	7	9
182	R:R:N56	R:R:P301	6.52	No	No	0	9	9
183	R:R:A80	R:R:V59	3.39	No	Yes	0	8	8
184	R:R:V305	R:R:V59	3.21	No	Yes	0	6	8
185	R:R:I60	R:R:I81	4.42	No	No	0	7	5
186	R:R:F62	R:R:W61	6.01	Yes	No	0	7	4
187	R:R:F65	R:R:W61	9.02	No	No	0	4	4
188	R:R:K66	R:R:W61	3.48	No	No	0	5	4
189	R:R:F311	R:R:F62	8.57	Yes	Yes	0	8	7
190	R:R:F62	R:R:R314	4.28	Yes	Yes	0	7	6
191	R:R:F315	R:R:F62	5.36	No	Yes	0	5	7
192	R:R:G64	R:R:T63	3.64	No	No	0	3	7
193	R:R:K66	R:R:R314	6.19	No	Yes	0	5	6
194	R:R:R314	R:R:W67	17.99	Yes	No	0	6	6
195	R:R:T70	R:R:T73	7.85	No	No	0	7	8
196	R:R:V71	R:R:W75	4.9	No	Yes	0	6	7
197	R:R:R149	R:R:V71	5.23	No	No	0	7	6
198	R:R:S154	R:R:V71	4.85	No	No	0	7	6
199	R:R:F76	R:R:T72	3.89	No	No	0	8	7
200	R:R:I158	R:R:L74	2.85	No	No	0	7	6
201	R:R:V130	R:R:W75	6.13	No	Yes	0	6	7
202	R:R:I131	R:R:W75	4.7	No	Yes	0	8	7
203	R:R:D134	R:R:W75	12.28	No	Yes	0	8	7
204	R:R:V157	R:R:W75	3.68	No	Yes	0	6	7
205	R:R:I158	R:R:W75	4.7	No	Yes	0	7	7
206	R:R:F76	R:R:Y304	4.13	No	No	0	8	9
207	R:R:I81	R:R:L77	2.85	No	No	0	5	6
208	R:R:F127	R:R:N78	12.08	No	No	14	7	9
209	R:R:I158	R:R:N78	11.33	No	No	0	7	9
210	R:R:N78	R:R:W162	6.78	No	Yes	14	9	9
211	R:R:D83	R:R:L79	5.43	Yes	No	13	9	9
212	R:R:L79	R:R:S124	3	No	No	13	9	9
213	R:R:L128	R:R:L79	2.77	No	No	0	9	9
214	R:R:I81	R:R:I85	2.94	No	No	0	5	6
215	R:R:D83	R:R:S124	5.89	Yes	No	13	9	9
216	R:R:D83	R:R:N300	8.08	Yes	No	0	9	9
217	R:R:F84	R:R:L88	3.65	No	No	0	7	5
218	R:R:I85	R:R:N120	8.5	No	Yes	0	6	8
219	R:R:A117	R:R:F86	2.77	No	Yes	12	6	7
220	R:R:F86	R:R:N120	6.04	Yes	Yes	0	7	8
221	R:R:F294	R:R:F86	12.86	No	Yes	0	7	7
222	R:R:F86	R:R:S297	6.61	Yes	No	0	7	8
223	R:R:F89	R:R:L88	7.31	No	No	0	6	5
224	R:R:L90	R:R:P91	3.28	No	No	0	7	9
225	R:R:I94	R:R:L90	8.56	No	No	0	6	7
226	R:R:F294	R:R:L90	7.31	No	No	0	7	7
227	R:R:L92	R:R:W103	3.42	No	Yes	0	6	9
228	R:R:L109	R:R:L92	4.15	No	No	0	5	6
229	R:R:Y93	R:R:Y96	2.98	No	No	0	6	6
230	R:R:T290	R:R:Y93	9.99	No	No	0	6	6
231	R:R:F105	R:R:S95	3.96	Yes	No	0	7	4
232	R:R:F101	R:R:Y96	6.19	Yes	No	0	4	6
233	R:R:W103	R:R:Y96	7.72	Yes	No	0	9	6
234	R:R:F101	R:R:V97	3.93	Yes	No	0	4	5
235	R:R:H102	R:R:M99	5.25	No	No	0	5	4
236	R:R:F101	R:R:P287	2.89	Yes	No	0	4	4
237	R:R:H102	R:R:P104	9.15	No	No	0	5	3
238	R:R:H102	R:R:T185	4.11	No	No	0	5	4
239	R:R:F105	R:R:W103	6.01	Yes	Yes	0	7	9
240	R:R:C110	R:R:W103	10.45	No	Yes	0	9	9
241	R:R:F105	R:R:P104	5.78	Yes	No	0	7	3
242	R:R:F105	R:R:L109	6.09	Yes	No	0	7	5
243	R:R:I107	R:R:W108	8.22	No	No	0	4	1
244	R:R:D177	R:R:I107	2.8	No	No	0	5	4
245	R:R:I107	R:R:T178	3.04	No	No	0	4	5
246	R:R:C110	R:R:T178	3.38	No	No	0	9	5
247	R:R:C110	R:R:C187	5.46	No	No	0	9	9
248	R:R:R176	R:R:S114	10.54	No	No	0	4	5
249	R:R:F115	R:R:G170	3.01	No	No	0	6	4
250	R:R:F115	R:R:L173	13.4	No	No	0	6	4
251	R:R:N120	R:R:T116	2.92	Yes	No	0	8	5
252	R:R:F122	R:R:Q118	3.51	Yes	Yes	0	6	5
253	R:R:G169	R:R:Q118	6.58	No	Yes	0	7	5
254	R:R:A172	R:R:Q118	3.03	No	Yes	0	4	5
255	R:R:L119	R:R:W162	3.42	No	Yes	0	5	9
256	R:R:F122	R:R:M121	3.73	Yes	No	0	6	7
257	R:R:M121	R:R:W259	6.98	No	Yes	0	7	8
258	R:R:F122	R:R:I168	8.79	Yes	No	15	6	5
259	R:R:F122	R:R:K210	3.72	Yes	No	0	6	6
260	R:R:F122	R:R:I213	3.77	Yes	No	15	6	4
261	R:R:F122	R:R:G214	3.01	Yes	No	0	6	5
262	R:R:A123	R:R:W162	5.19	No	Yes	0	6	9
263	R:R:P218	R:R:V125	3.53	Yes	No	0	9	7
264	R:R:F126	R:R:I161	6.28	No	No	0	5	7
265	R:R:F126	R:R:L164	4.87	No	No	0	5	4
266	R:R:F127	R:R:I161	11.3	No	No	0	7	7
267	R:R:F127	R:R:W162	7.02	No	Yes	14	7	9
268	R:R:L128	R:R:N300	8.24	No	No	0	9	9
269	R:R:L128	R:R:Y304	3.52	No	No	0	9	9
270	R:R:P218	R:R:T129	3.5	Yes	No	0	9	7
271	R:R:T129	R:R:T221	3.14	No	No	0	7	6
272	R:R:M222	R:R:S132	6.13	No	No	0	8	9
273	R:R:S132	R:R:Y226	12.72	No	No	0	9	9
274	R:R:C225	R:R:L133	4.76	No	No	0	6	6
275	R:R:D134	R:R:R149	10.72	No	No	0	8	7
276	R:R:H135	R:R:L139	10.29	No	No	0	9	8
277	R:R:I137	R:R:Y136	3.63	No	Yes	0	5	7
278	R:R:H141	R:R:Y136	4.36	Yes	Yes	0	6	7
279	R:R:C225	R:R:Y136	4.03	No	Yes	0	6	7
280	R:R:K232	R:R:Y136	3.58	No	Yes	0	5	7
281	R:R:H138	R:R:L139	3.86	No	No	0	8	8
282	R:R:H138	R:R:S145	2.79	No	No	0	8	6
283	R:R:H138	R:R:R149	22.57	No	No	0	8	7
284	R:R:H141	R:R:I140	7.95	Yes	Yes	0	6	7
285	R:R:I140	R:R:L229	2.85	Yes	No	0	7	7
286	R:R:I140	R:R:K232	5.82	Yes	No	0	7	5
287	R:R:H148	R:R:R147	15.8	No	No	0	3	5
288	R:R:N153	R:R:T150	7.31	No	No	0	4	6
289	R:R:I159	R:R:L163	2.85	No	No	0	3	4
290	R:R:I168	R:R:I213	4.42	No	No	15	5	4
291	R:R:G170	R:R:P171	4.06	No	No	0	4	8
292	R:R:F175	R:R:P171	2.89	Yes	No	0	4	8
293	R:R:L206	R:R:P171	3.28	No	No	0	5	8
294	R:R:F175	R:R:Y174	5.16	Yes	No	0	4	5
295	R:R:F175	R:R:F191	9.65	Yes	Yes	0	4	5
296	R:R:F175	R:R:R202	7.48	Yes	No	0	4	1
297	R:R:C187	R:R:R176	5.57	No	No	0	9	4
298	R:R:N189	R:R:R176	14.46	No	No	0	4	4
299	R:R:D177	R:R:Y188	4.6	No	Yes	2	5	3
300	R:R:D177	R:R:N190	5.39	No	No	2	5	3
301	R:R:V179	R:R:Y188	7.57	No	Yes	2	1	3
302	R:R:N190	R:R:Y188	8.14	No	Yes	2	3	3
303	R:R:F191	R:R:N189	3.62	Yes	No	0	5	4
304	R:R:K193	R:R:N190	9.79	No	No	0	2	3
305	R:R:F191	R:R:H203	13.58	Yes	No	0	5	4
306	R:R:F191	R:R:L206	3.65	Yes	No	0	5	5
307	R:R:H194	R:R:K193	3.93	No	No	0	3	2
308	R:R:D195	R:R:P196	4.83	No	No	0	2	1
309	R:R:D195	R:R:L198	6.79	No	No	0	2	4
310	R:R:L198	R:R:R202	10.93	No	No	0	4	1
311	R:R:H204	R:R:L200	6.43	No	No	0	4	2
312	R:R:H273	R:R:L200	7.71	No	No	0	3	2
313	R:R:H203	R:R:H273	4.78	No	No	0	4	3
314	R:R:H204	R:R:W208	5.29	No	No	0	4	4
315	R:R:H204	R:R:L270	10.29	No	No	0	4	5
316	R:R:S266	R:R:T207	4.8	No	No	0	5	5
317	R:R:L270	R:R:T207	7.37	No	No	0	5	5
318	R:R:F211	R:R:W208	4.01	Yes	No	0	6	4
319	R:R:I267	R:R:W208	7.05	No	No	0	5	4
320	R:R:K210	R:R:Y262	3.58	No	No	0	6	6
321	R:R:F211	R:R:Y215	7.22	Yes	No	16	6	8
322	R:R:F211	R:R:L216	3.65	Yes	No	0	6	4
323	R:R:F211	R:R:H263	4.53	Yes	No	16	6	8
324	R:R:I212	R:R:I213	2.94	No	No	0	5	4
325	R:R:I212	R:R:L216	4.28	No	No	0	5	4
326	R:R:G214	R:R:P218	4.06	No	Yes	0	5	9
327	R:R:T260	R:R:Y215	9.99	No	No	0	5	8
328	R:R:H263	R:R:Y215	8.71	No	No	16	8	8
329	R:R:F217	R:R:P218	7.22	No	Yes	0	6	9
330	R:R:F217	R:R:T221	3.89	No	No	0	6	6
331	R:R:F255	R:R:L219	3.65	No	No	0	9	6
332	R:R:M222	R:R:V252	3.04	No	No	0	8	7
333	R:R:I248	R:R:Y226	3.63	No	No	0	7	9
334	R:R:I230	R:R:K234	2.91	Yes	No	0	4	5
335	R:R:F245	R:R:I230	6.28	No	Yes	0	6	4
336	R:R:I238	R:R:R236	7.52	No	No	0	4	5
337	R:R:H244	R:R:I240	9.28	No	No	0	7	5
338	R:R:K309	R:R:R243	4.95	No	No	0	6	7
339	R:R:F245	R:R:L249	3.65	No	No	0	6	4
340	R:R:L303	R:R:V250	2.98	No	No	0	8	6
341	R:R:V251	R:R:Y304	11.36	No	No	0	7	9
342	R:R:F255	R:R:W259	8.02	No	Yes	0	9	8
343	R:R:C258	R:R:V257	3.42	No	No	0	7	5
344	R:R:C258	R:R:N296	4.72	No	No	0	7	9
345	R:R:W259	R:R:Y262	2.89	Yes	No	0	8	6
346	R:R:A293	R:R:W259	5.19	No	Yes	0	8	8
347	R:R:N296	R:R:W259	13.56	No	Yes	0	9	8
348	R:R:P261	R:R:T260	6.99	No	No	0	9	5
349	R:R:L264	R:R:T260	2.95	No	No	0	5	5
350	R:R:S289	R:R:Y262	5.09	No	No	0	7	6
351	R:R:F265	R:R:G285	3.01	No	No	0	4	6
352	R:R:F265	R:R:S289	5.28	No	No	0	4	7
353	R:R:T271	R:R:W268	3.64	No	No	0	4	4
354	R:R:V281	R:R:W268	12.26	No	No	0	1	4
355	R:R:E269	R:R:M282	9.47	No	No	0	4	4
356	R:R:S276	R:R:T271	3.2	No	No	0	3	4
357	R:R:N275	R:R:Y277	6.98	No	No	0	3	1
358	R:R:S276	R:R:S278	4.89	No	No	0	3	2
359	R:R:S278	R:R:V281	3.23	No	No	0	2	1
360	R:R:I286	R:R:P287	3.39	No	No	0	4	4
361	R:R:N296	R:R:N300	5.45	No	No	0	9	9
362	R:R:L299	R:R:L303	4.15	No	No	0	7	8
363	R:R:F311	R:R:V305	3.93	Yes	No	0	8	6
364	R:R:F311	R:R:L306	6.09	Yes	No	0	8	6
365	R:R:K310	R:R:S308	7.65	No	No	0	6	8
366	R:R:R316	R:R:V319	3.92	No	No	0	6	5
367	R:R:L119	R:R:N120	2.75	No	Yes	0	5	8
368	L:L:E53	L:L:K97	2.7	No	No	0	5	4
369	R:R:C228	R:R:Y136	2.69	No	Yes	0	4	7
370	L:L:L124	L:L:Q122	2.66	No	No	0	2	6
371	R:R:D195	R:R:D197	2.66	No	No	0	2	4
372	R:R:F115	R:R:S166	2.64	No	No	0	6	4
373	R:R:R243	R:R:S241	2.64	No	No	0	7	7
374	R:R:R314	R:R:S318	2.64	Yes	No	0	6	6
375	R:R:F49	R:R:V50	2.62	No	No	0	7	4
376	R:R:A82	R:R:W162	2.59	No	Yes	0	8	9
377	R:R:H135	R:R:L229	2.57	No	No	0	9	7
378	R:R:H148	R:R:L144	2.57	No	No	0	3	5
379	L:L:V43	R:R:Y17	2.52	No	No	0	8	4
380	R:R:F84	R:R:I53	2.51	No	No	0	7	6
381	R:R:F311	R:R:I58	2.51	Yes	No	0	8	6
382	R:R:F255	R:R:M222	2.49	No	No	0	9	8
383	L:L:H116	L:L:Q131	2.47	Yes	Yes	4	8	5
384	L:L:H130	L:L:Q131	2.47	No	Yes	4	4	5
385	R:R:H135	R:R:H244	2.39	No	No	0	9	7
386	R:R:H273	R:R:H274	2.39	No	No	0	3	3
387	L:L:F60	L:L:Q139	2.34	Yes	No	0	4	5
388	L:L:Q74	L:L:R90	2.34	Yes	No	0	9	4
389	L:L:F60	L:L:R140	2.14	Yes	No	0	4	4
390	L:L:G105	L:L:G63	2.11	No	No	0	5	9
391	R:R:G52	R:R:P54	2.03	No	No	0	8	4
392	R:R:G55	R:R:P54	2.03	No	No	0	7	4
393	L:L:A141	L:L:G142	1.95	No	No	0	6	6
394	L:L:G29	L:L:V32	1.84	No	No	0	6	6
395	L:L:G29	L:L:V66	1.84	No	No	0	6	9
396	R:R:A48	R:R:C298	1.81	No	Yes	0	6	7
397	R:R:A123	R:R:A165	1.79	No	No	0	6	8
398	R:R:P301	R:R:V59	1.77	No	Yes	0	9	8
399	R:R:P196	R:R:T199	1.75	No	No	0	1	6
400	L:L:G93	L:L:K95	1.74	No	No	0	6	6
401	L:L:G105	L:L:L104	1.71	No	No	0	5	9
402	L:L:A55	L:L:V52	1.7	No	No	0	6	7
403	R:R:L292	R:R:P261	1.64	No	No	0	7	9
404	R:R:S241	R:R:S242	1.63	No	No	0	7	5
405	L:L:A155	R:R:I286	1.62	No	No	0	9	4
406	R:R:S223	R:R:V252	1.62	No	No	0	3	7
407	L:L:P118	R:R:D20	1.61	No	No	0	7	2
408	L:L:S76	L:L:T75	1.6	No	Yes	0	3	9
409	R:R:C298	R:R:L51	1.59	Yes	No	0	7	5
410	R:R:T63	R:R:V59	1.59	No	Yes	0	7	8
411	R:R:C298	R:R:L299	1.59	Yes	No	0	7	7
412	L:L:A55	L:L:L68	1.58	No	Yes	0	6	8
413	R:R:A98	R:R:L42	1.58	No	No	0	4	5
414	R:R:A48	R:R:L295	1.58	No	No	0	6	5
415	R:R:A112	R:R:L109	1.58	No	No	0	4	5
416	R:R:P196	R:R:Q192	1.58	No	No	0	1	4
417	R:R:A254	R:R:L303	1.58	No	No	0	7	8
418	L:L:E143	L:L:P61	1.57	No	No	0	6	4
419	R:R:T63	R:R:T73	1.57	No	No	0	7	8
420	R:R:T72	R:R:T73	1.57	No	No	0	7	8
421	R:R:I272	R:R:S276	1.55	No	No	0	2	3
422	R:R:I140	R:R:V233	1.54	Yes	No	0	7	8
423	R:R:I168	R:R:V209	1.54	No	No	0	5	2
424	R:R:I201	R:R:V205	1.54	No	No	0	1	3
425	R:R:I238	R:R:V233	1.54	No	No	0	4	8
426	R:R:I240	R:R:V233	1.54	No	No	0	5	8
427	L:L:K88	L:L:S76	1.53	No	No	0	6	3
428	R:R:H141	R:R:P142	1.53	Yes	No	0	6	8
429	L:L:C135	L:L:E132	1.52	No	No	0	9	5
430	R:R:L87	R:R:S297	1.5	No	No	0	6	8
431	R:R:K152	R:R:T150	1.5	No	No	0	5	6
432	R:R:L42	R:R:V97	1.49	No	No	0	5	5
433	R:R:L219	R:R:V256	1.49	No	No	0	6	5
434	R:R:I230	R:R:I248	1.47	Yes	No	0	4	7
435	L:L:P91	L:L:R90	1.44	No	No	0	5	4
436	R:R:K309	R:R:K310	1.44	No	No	0	6	6
437	L:L:E126	L:L:V123	1.43	No	No	0	6	3
438	R:R:I302	R:R:L306	1.43	No	No	0	6	6
439	L:L:E21	L:L:T23	1.41	No	No	0	4	6
440	R:R:K111	R:R:L173	1.41	No	No	0	7	4
441	R:R:L47	R:R:L51	1.38	No	No	0	4	5
442	R:R:L295	R:R:L47	1.38	No	No	0	5	4
443	R:R:L151	R:R:L74	1.38	No	No	0	3	6
444	R:R:L155	R:R:L74	1.38	No	No	0	4	6
445	R:R:L92	R:R:N113	1.37	No	No	0	6	5
446	R:R:D20	R:R:L19	1.36	No	No	0	2	3
447	R:R:E30	R:R:K31	1.35	No	No	0	5	1
448	L:L:E132	L:L:L136	1.33	No	No	0	5	3
449	L:L:L136	L:L:Q139	1.33	No	No	0	3	5
450	L:L:L136	R:R:Q192	1.33	No	No	0	3	4
451	R:R:N100	R:R:Q33	1.32	No	No	0	3	2
452	L:L:R125	L:L:V123	1.31	No	No	0	5	3
453	R:R:D27	R:R:E25	1.3	No	No	0	4	7
454	R:R:H141	R:R:L144	1.29	Yes	No	0	6	5
455	R:R:R243	R:R:T247	1.29	No	No	0	7	7
456	R:R:F231	R:R:I230	1.26	No	Yes	0	3	4
457	R:R:H280	R:R:Q283	1.24	No	No	0	3	3
458	R:R:F160	R:R:L164	1.22	No	No	0	3	4
459	R:R:F231	R:R:L227	1.22	No	No	0	3	3
460	R:R:K68	R:R:W67	1.16	No	No	0	7	6
461	R:R:F245	R:R:W246	1	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R28	8.415	4	7	7
2	L:L:F47	6.7775	4	1	9
3	L:L:F60	2.815	4	0	4
4	L:L:F65	6.1875	4	10	8
5	L:L:L68	5.1225	4	0	8
6	L:L:F70	6.392	5	0	6
7	L:L:K71	6.048	5	5	4
8	L:L:Q73	5.4925	4	5	7
9	L:L:Q74	6.91167	6	1	9
10	L:L:T75	5.8375	4	3	9
11	L:L:R113	10.42	4	0	7
12	L:L:H116	5.4075	4	4	8
13	L:L:Q131	4.1575	4	4	5
14	L:L:H146	7.345	4	11	5
15	L:L:F148	6.258	5	0	1
16	L:L:Y149	8.202	5	2	5
17	L:L:F150	8.536	5	2	4
18	L:L:Q153	7.445	4	2	6
19	L:L:F154	9.198	5	2	6
20	R:R:Y15	11.32	4	1	8
21	R:R:Y22	4.332	5	4	5
22	R:R:V32	5.6525	4	0	3
23	R:R:Y45	4.912	5	0	8
24	R:R:V59	2.49	4	0	8
25	R:R:F62	6.055	4	0	7
26	R:R:W75	6.065	6	0	7
27	R:R:D83	5.86	4	13	9
28	R:R:F86	6.3	5	12	7
29	R:R:F101	7.03167	6	0	4
30	R:R:W103	6.9	4	0	9
31	R:R:F105	5.46	4	0	7
32	R:R:Q118	6.1675	4	0	5
33	R:R:N120	5.0525	4	0	8
34	R:R:F122	4.42167	6	15	6
35	R:R:Y136	3.658	5	0	7
36	R:R:I140	4.54	4	0	7
37	R:R:H141	3.7825	4	0	6
38	R:R:W162	5	5	14	9
39	R:R:F175	6.295	4	0	4
40	R:R:Y188	7.6575	4	2	3
41	R:R:F191	6.966	5	0	5
42	R:R:F211	4.8525	4	16	6
43	R:R:P218	4.5775	4	0	9
44	R:R:I230	2.98	4	0	4
45	R:R:W259	7.328	5	0	8
46	R:R:C298	2.2275	4	0	7
47	R:R:F311	5.275	4	0	8
48	R:R:R314	7.775	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V110	L:L:V32	10.8654	4.81	No	No	0	8	6
2	L:L:G29	L:L:V32	15.6681	1.84	No	No	0	6	6
3	L:L:G29	L:L:V66	16.8441	1.84	No	No	0	6	9
4	L:L:L68	L:L:V66	18.0159	7.45	Yes	No	0	8	9
5	L:L:F70	L:L:L68	29.484	7.31	Yes	Yes	0	6	8
6	L:L:E49	L:L:F70	45.0786	16.32	No	Yes	0	6	6
7	L:L:E49	L:L:L72	42.9009	13.25	No	No	1	6	8
8	L:L:I102	L:L:R113	75.5413	5.01	No	Yes	0	5	7
9	L:L:A100	L:L:I102	74.6089	3.25	No	No	0	8	5
10	L:L:A100	L:L:F70	73.6744	2.77	No	Yes	0	8	6
11	R:R:S23	R:R:Y21	12.0519	3.82	No	No	0	5	3
12	L:L:R113	R:R:S23	13.1754	5.27	Yes	No	0	7	5
13	L:L:F47	L:L:Q74	30.9897	8.2	Yes	Yes	1	9	9
14	L:L:F47	L:L:L72	41.9517	6.09	Yes	No	1	9	8
15	L:L:G93	L:L:Q74	25.0908	4.93	No	Yes	0	6	9
16	L:L:G93	L:L:K95	23.9379	1.74	No	No	0	6	6
17	L:L:K95	L:L:Q73	15.5862	9.49	No	Yes	5	6	7
18	L:L:Q73	L:L:V89	13.3728	2.87	Yes	No	0	7	4
19	L:L:Q48	L:L:V89	12.1779	5.73	No	No	0	4	4
20	L:L:Q48	L:L:T75	10.9788	9.92	No	Yes	0	4	9
21	L:L:R113	R:R:E25	94.96	16.28	Yes	No	0	7	7
22	R:R:E25	R:R:N182	96.6568	5.26	No	No	0	7	3
23	R:R:K31	R:R:N182	97.4989	5.6	No	No	0	1	3
24	R:R:H184	R:R:K31	99.1705	7.86	No	No	0	3	1
25	R:R:H184	R:R:V32	100	2.77	No	Yes	0	3	3
26	R:R:F101	R:R:V32	83.6641	5.24	Yes	Yes	0	4	3
27	L:L:F154	R:R:F101	56.4817	17.15	Yes	Yes	0	6	4
28	L:L:F154	L:L:Q153	34.482	12.88	Yes	Yes	2	6	6
29	L:L:F150	L:L:Q153	34.4232	8.2	Yes	Yes	2	4	6
30	L:L:F150	L:L:R137	29.7045	10.69	Yes	No	0	4	5
31	L:L:Q134	L:L:R137	20.5359	3.5	No	No	0	6	5
32	L:L:Q134	R:R:Y22	19.4271	3.38	No	Yes	0	6	5
33	L:L:H116	R:R:Y22	17.3229	4.36	Yes	Yes	4	8	5
34	R:R:Q283	R:R:V32	24.2739	5.73	No	Yes	0	3	3
35	L:L:F154	R:R:Q283	24.3243	7.03	Yes	No	0	6	3
36	L:L:F154	L:L:Y149	43.0332	5.16	Yes	Yes	2	6	5
37	L:L:Y149	R:R:I272	23.7762	4.84	Yes	No	0	5	2
38	L:L:H146	R:R:I272	17.4384	10.61	Yes	No	0	5	2
39	L:L:D144	L:L:H146	30.1287	7.56	No	Yes	11	4	5
40	L:L:D144	L:L:S147	28.1169	2.94	No	No	0	4	3
41	L:L:A141	L:L:S147	26.9052	3.42	No	No	0	6	3
42	L:L:A141	L:L:K103	24.5994	3.21	No	No	0	6	9
43	L:L:F65	L:L:K103	25.9791	3.72	Yes	No	0	8	9
44	L:L:F65	L:L:Q139	18.7677	14.05	Yes	No	0	8	5
45	L:L:F60	L:L:Q139	11.5521	2.34	Yes	No	0	4	5
46	L:L:Y149	R:R:H279	18.1797	14.16	Yes	No	0	5	1
47	L:L:H146	R:R:H279	17.1234	3.58	Yes	No	0	5	1
48	L:L:F150	R:R:Y188	15.0255	10.32	Yes	Yes	2	4	3
49	R:R:F101	R:R:Y96	92.0809	6.19	Yes	No	0	4	6
50	R:R:W103	R:R:Y96	86.1862	7.72	Yes	No	0	9	6
51	R:R:C110	R:R:W103	81.5998	10.45	No	Yes	0	9	9
52	R:R:C110	R:R:C187	90.5164	5.46	No	No	0	9	9
53	R:R:C187	R:R:R176	90.1636	5.57	No	No	0	9	4
54	R:R:N189	R:R:R176	89.4664	14.46	No	No	0	4	4
55	R:R:F191	R:R:N189	89.1367	3.62	Yes	No	0	5	4
56	L:L:F156	R:R:T290	78.5254	9.08	No	No	0	9	6
57	R:R:T290	R:R:Y93	79.147	9.99	No	No	0	6	6
58	R:R:Y93	R:R:Y96	80.7934	2.98	No	No	0	6	6
59	L:L:F156	R:R:F86	77.0806	3.22	No	Yes	12	9	7
60	R:R:F191	R:R:H203	85.174	13.58	Yes	No	0	5	4
61	R:R:H203	R:R:H273	84.6553	4.78	No	No	0	4	3
62	R:R:H273	R:R:L200	83.6053	7.71	No	No	0	3	2
63	R:R:H204	R:R:L200	83.074	6.43	No	No	0	4	2
64	R:R:H204	R:R:W208	80.9068	5.29	No	No	0	4	4
65	R:R:F211	R:R:W208	79.798	4.01	Yes	No	0	6	4
66	R:R:F211	R:R:L216	75.7849	3.65	Yes	No	0	6	4
67	R:R:I212	R:R:L216	75.1948	4.28	No	No	0	5	4
68	R:R:I212	R:R:I213	74.6005	2.94	No	No	0	5	4
69	R:R:F122	R:R:I213	72.4102	3.77	Yes	No	15	6	4
70	R:R:F122	R:R:M121	61.0576	3.73	Yes	No	0	6	7
71	R:R:M121	R:R:W259	60.3919	6.98	No	Yes	0	7	8
72	R:R:N296	R:R:W259	48.1509	13.56	No	Yes	0	9	8
73	R:R:N296	R:R:N300	45.8514	5.45	No	No	0	9	9
74	R:R:D83	R:R:N300	38.2347	8.08	Yes	No	0	9	9
75	R:R:D83	R:R:N56	36.0423	4.04	Yes	No	0	9	9
76	R:R:F84	R:R:N56	18.1923	4.83	No	No	0	7	9
77	R:R:F84	R:R:I53	15.4203	2.51	No	No	0	7	6
78	R:R:I53	R:R:P54	12.6105	5.08	No	No	0	6	4
79	R:R:G52	R:R:P54	10.7163	2.03	No	No	0	8	4
80	R:R:N56	R:R:P301	18.8643	6.52	No	No	0	9	9
81	R:R:P301	R:R:V59	17.9676	1.77	No	Yes	0	9	8
82	R:R:V305	R:R:V59	14.3934	3.21	No	Yes	0	6	8
83	R:R:F86	R:R:N120	78.2188	6.04	Yes	Yes	0	7	8
84	R:R:F311	R:R:V305	13.4631	3.93	Yes	No	0	8	6
85	R:R:L119	R:R:N120	74.0608	2.75	No	Yes	0	5	8
86	R:R:L119	R:R:W162	73.3531	3.42	No	Yes	0	5	9
87	R:R:N78	R:R:W162	66.0178	6.78	No	Yes	14	9	9
88	R:R:I158	R:R:N78	66.0451	11.33	No	No	0	7	9
89	R:R:I158	R:R:W75	63.0043	4.7	No	Yes	0	7	7
90	R:R:V71	R:R:W75	30.4164	4.9	No	Yes	0	6	7
91	R:R:R149	R:R:V71	28.7028	5.23	No	No	0	7	6
92	R:R:D134	R:R:W75	29.484	12.28	No	Yes	0	8	7
93	R:R:D134	R:R:R149	28.6356	10.72	No	No	0	8	7
94	R:R:C110	R:R:T178	14.9058	3.38	No	No	0	9	5
95	R:R:I107	R:R:T178	14.2485	3.04	No	No	0	4	5
96	R:R:D177	R:R:Y188	11.1027	4.6	No	Yes	2	5	3
97	R:R:F175	R:R:F191	18.5115	9.65	Yes	Yes	0	4	5
98	R:R:F255	R:R:W259	15.3111	8.02	No	Yes	0	9	8
99	R:R:F255	R:R:M222	12.5202	2.49	No	No	0	9	8
100	R:R:H138	R:R:R149	55.5451	22.57	No	No	0	8	7
101	R:R:H138	R:R:L139	51.9583	3.86	No	No	0	8	8
102	R:R:H135	R:R:L139	50.1585	10.29	No	No	0	9	8
103	R:R:H135	R:R:L229	39.1104	2.57	No	No	0	9	7
104	R:R:I140	R:R:L229	37.2897	2.85	Yes	No	0	7	7
105	R:R:H141	R:R:I140	18.7824	7.95	Yes	Yes	0	6	7
106	R:R:I140	R:R:K232	11.2728	5.82	Yes	No	0	7	5
107	R:R:F175	R:R:R202	12.0183	7.48	Yes	No	0	4	1
108	R:R:L198	R:R:R202	11.2497	10.93	No	No	0	4	1
109	R:R:D195	R:R:L198	10.5546	6.79	No	No	0	2	4
110	R:R:D177	R:R:I107	13.0893	2.8	No	No	0	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F37	R:R:Y21	10.32	0	No	No	8	3	0	1
L:L:P42	R:R:D18	8.05	9	No	No	5	6	0	1
L:L:V43	R:R:D18	5.84	9	No	No	8	6	0	1
L:L:Q44	R:R:Y15	5.64	0	No	Yes	5	8	0	1
L:L:W45	R:R:Y15	9.65	1	No	Yes	4	8	0	1
L:L:Q74	R:R:Y15	7.89	1	Yes	Yes	9	8	0	1
L:L:R94	R:R:Y17	6.17	1	No	No	8	4	0	1
L:L:L111	R:R:L28	4.15	0	No	No	8	2	0	1
L:L:G112	R:R:S26	3.71	0	No	No	5	4	0	1
L:L:R113	R:R:S23	5.27	0	Yes	No	7	5	0	1
L:L:R113	R:R:E25	16.28	0	Yes	No	7	7	0	1
L:L:L114	R:R:Y22	3.52	4	No	Yes	7	5	0	1
L:L:L114	R:R:L24	4.15	4	No	No	7	4	0	1
L:L:V115	R:R:Y21	6.31	0	No	No	3	3	0	1
L:L:H116	R:R:Y22	4.36	4	Yes	Yes	8	5	0	1
L:L:I119	R:R:Y17	8.46	0	No	No	4	4	0	1
L:L:E129	R:R:H194	8.62	0	No	No	3	3	0	1
L:L:T133	R:R:Q192	5.67	0	No	No	4	4	0	1
L:L:Q134	R:R:Y22	3.38	0	No	Yes	6	5	0	1
L:L:H146	R:R:I272	10.61	11	Yes	No	5	2	0	1
L:L:H146	R:R:H279	3.58	11	Yes	No	5	1	0	1
L:L:F148	R:R:L24	6.09	0	Yes	No	1	4	0	1
L:L:F148	R:R:S26	6.61	0	Yes	No	1	4	0	1
L:L:F148	R:R:E29	4.66	0	Yes	No	1	6	0	1
L:L:F148	R:R:F181	9.65	0	Yes	No	1	4	0	1
L:L:Y149	R:R:E269	13.47	2	Yes	No	5	4	0	1
L:L:Y149	R:R:I272	4.84	2	Yes	No	5	2	0	1
L:L:Y149	R:R:H279	14.16	2	Yes	No	5	1	0	1
L:L:F150	R:R:V179	9.18	2	Yes	No	4	1	0	1
L:L:F150	R:R:F181	4.29	2	Yes	No	4	4	0	1
L:L:F150	R:R:Y188	10.32	2	Yes	Yes	4	3	0	1
L:L:P151	R:R:F191	4.33	0	No	Yes	9	5	0	1
L:L:Q153	R:R:L186	5.32	2	Yes	No	6	3	0	1
L:L:F154	R:R:F101	17.15	2	Yes	Yes	6	4	0	1
L:L:F154	R:R:Q283	7.03	2	Yes	No	6	3	0	1
L:L:F154	R:R:I286	3.77	2	Yes	No	6	4	0	1
L:L:F156	R:R:F86	3.22	12	No	Yes	9	7	0	1
L:L:F156	R:R:A117	2.77	12	No	No	9	6	0	1
L:L:F156	R:R:T290	9.08	12	No	No	9	6	0	1
L:L:S157	R:R:Q118	11.55	0	No	Yes	5	5	0	1
R:R:N14	R:R:Y15	22.1	0	No	Yes	7	8	2	1
R:R:S23	R:R:Y21	3.82	0	No	No	5	3	1	1
R:R:L24	R:R:Y22	7.03	4	No	Yes	4	5	1	1
R:R:E180	R:R:Y22	3.37	0	No	Yes	1	5	2	1
R:R:E25	R:R:N182	5.26	0	No	No	7	3	1	2
R:R:F101	R:R:V32	5.24	0	Yes	Yes	4	3	1	2
R:R:Q283	R:R:V32	5.73	0	No	Yes	3	3	1	2
R:R:F101	R:R:H38	6.79	0	Yes	No	4	5	1	2
R:R:A117	R:R:F86	2.77	12	No	Yes	6	7	1	1
R:R:F86	R:R:N120	6.04	12	Yes	Yes	7	8	1	2
R:R:F294	R:R:F86	12.86	0	No	Yes	7	7	2	1
R:R:F86	R:R:S297	6.61	12	Yes	No	7	8	1	2
R:R:Y93	R:R:Y96	2.98	0	No	No	6	6	2	2
R:R:T290	R:R:Y93	9.99	0	No	No	6	6	1	2
R:R:F101	R:R:Y96	6.19	0	Yes	No	4	6	1	2
R:R:F101	R:R:V97	3.93	0	Yes	No	4	5	1	2
R:R:F101	R:R:P287	2.89	0	Yes	No	4	4	1	2
R:R:F122	R:R:Q118	3.51	15	Yes	Yes	6	5	2	1
R:R:G169	R:R:Q118	6.58	0	No	Yes	7	5	2	1
R:R:A172	R:R:Q118	3.03	0	No	Yes	4	5	2	1
R:R:F175	R:R:F191	9.65	0	Yes	Yes	4	5	2	1
R:R:D177	R:R:Y188	4.6	2	No	Yes	5	3	2	1
R:R:D177	R:R:N190	5.39	2	No	No	5	3	2	2
R:R:V179	R:R:Y188	7.57	2	No	Yes	1	3	1	1
R:R:N190	R:R:Y188	8.14	2	No	Yes	3	3	2	1
R:R:F191	R:R:N189	3.62	0	Yes	No	5	4	1	2
R:R:K193	R:R:N190	9.79	0	No	No	2	3	2	2
R:R:F191	R:R:H203	13.58	0	Yes	No	5	4	1	2
R:R:F191	R:R:L206	3.65	0	Yes	No	5	5	1	2
R:R:H194	R:R:K193	3.93	0	No	No	3	2	1	2
R:R:E269	R:R:M282	9.47	0	No	No	4	4	1	2
R:R:I286	R:R:P287	3.39	0	No	No	4	4	1	2
L:L:V43	R:R:Y17	2.52	9	No	No	8	4	0	1
L:L:A155	R:R:I286	1.62	0	No	No	9	4	0	1
L:L:P118	R:R:D20	1.61	0	No	No	7	2	0	1
R:R:P196	R:R:Q192	1.58	0	No	No	1	4	2	1
R:R:I272	R:R:S276	1.55	0	No	No	2	3	1	2
R:R:D20	R:R:L19	1.36	0	No	No	2	3	1	2
L:L:L136	R:R:Q192	1.33	0	No	No	3	4	0	1
R:R:D27	R:R:E25	1.3	0	No	No	4	7	2	1
R:R:H280	R:R:Q283	1.24	0	No	No	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XGM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	418
Number of Links	461
Number of Hubs	48
Number of Links mediated by Hubs	192
Number of Communities	16
Number of Nodes involved in Communities	66
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	124286
Length Of Smallest Path	3
Average Path Length	23.1645
Length of Longest Path	55
Minimum Path Strength	1.24
Average Path Strength	6.48652
Maximum Path Strength	16.645
Minimum Path Correlation	0.7
Average Path Correlation	0.962922
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	56.5907
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.3189
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Chemerin
UniProt	Q99969
Sequence	>8XGM_nogp_Chain_L E L T E A Q R R G L Q V A L E E F H K H P P V Q W A F Q E T S V E S A V D T P F P A G I F V R L E F K L Q Q T S C R K R D W K K P E C K V R P N G R K R K C L A C I K L G S E D K V L G R L V H C P I E T Q V L R E A E E H Q E T Q C L R V Q R A G E D P H S F Y F P G Q F A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>8XGM_nogp_Chain_R N Y S Y D L D Y Y S L E S D L E E K V Q L G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N F Q K H D P D L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S I L I S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F Q A R F R S S V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9UYH	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYH (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYI	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.2	2025-11-19	10.1126/science.adt8794
	9UYI (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.2	2025-11-19	10.1126/science.adt8794
	9UYJ	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYJ (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYL	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYL (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	chim(Arrestin3-CtArrestin2)	3.5	2025-11-19	10.1126/science.adt8794
	9UYM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.5	2025-11-19	10.1126/science.adt8794
	9UYN	A	Protein	Chemerin	CML2	Homo sapiens	-	-	Arrestin2	2.9	2025-11-19	10.1126/science.adt8794
	9UYN (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	-	-		2.9	2025-11-19	10.1126/science.adt8794

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XGM_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.