psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	12.22	Yes	No	0	0	7
2	L:L:?1	R:R:V107	5.03	Yes	No	0	0	6
3	L:L:?1	R:R:C110	5.36	Yes	No	0	0	6
4	L:L:?1	R:R:F188	8.23	Yes	Yes	1	0	7
5	L:L:?1	R:R:A192	3.55	Yes	No	1	0	6
6	L:L:?1	R:R:S193	5.07	Yes	No	1	0	6
7	L:L:?1	R:R:F284	9.6	Yes	Yes	1	0	7
8	L:L:?1	R:R:F285	4.11	Yes	Yes	1	0	6
9	L:L:?1	R:R:N288	4.64	Yes	Yes	1	0	6
10	R:R:L33	R:R:W307	14.81	No	Yes	0	6	5
11	R:R:C34	R:R:I37	3.27	No	No	0	3	6
12	R:R:C34	R:R:M84	3.24	No	No	0	3	5
13	R:R:T314	R:R:V36	4.76	No	No	0	6	7
14	R:R:I37	R:R:T40	6.08	No	No	0	6	7
15	R:R:I37	R:R:M80	5.83	No	No	0	6	7
16	R:R:T314	R:R:T40	4.71	No	No	0	6	7
17	R:R:A43	R:R:P317	3.74	No	Yes	0	9	9
18	R:R:D72	R:R:N44	17.5	No	No	0	9	9
19	R:R:L73	R:R:N44	5.49	No	No	0	7	9
20	R:R:N44	R:R:P317	6.52	No	Yes	0	9	9
21	R:R:L73	R:R:S45	6.01	No	No	0	7	4
22	R:R:F69	R:R:L47	8.53	Yes	No	4	9	9
23	R:R:L47	R:R:P321	6.57	No	No	4	9	7
24	R:R:I48	R:R:V66	3.07	No	No	0	8	7
25	R:R:I51	R:R:N62	5.66	No	No	2	8	9
26	R:R:I51	R:R:V66	4.61	No	No	0	8	7
27	R:R:F327	R:R:I51	5.02	Yes	No	2	8	8
28	R:R:P55	R:R:Q54	4.74	No	No	0	6	6
29	R:R:D326	R:R:L57	4.07	Yes	No	0	6	9
30	R:R:D123	R:R:S61	8.83	No	No	0	9	8
31	R:R:L127	R:R:S61	3	No	No	0	8	8
32	R:R:L65	R:R:N62	5.49	No	No	0	8	9
33	R:R:F327	R:R:N62	8.46	Yes	No	2	8	9
34	R:R:F63	R:R:V147	5.24	No	No	0	4	8
35	R:R:F64	R:R:L119	4.87	Yes	No	5	8	7
36	R:R:D123	R:R:F64	7.17	No	Yes	0	9	8
37	R:R:F64	R:R:L146	3.65	Yes	No	5	8	6
38	R:R:F69	R:R:L65	8.53	Yes	No	0	9	8
39	R:R:N116	R:R:S67	5.96	No	No	0	8	9
40	R:R:S67	R:R:V147	3.23	No	No	0	9	8
41	R:R:S67	R:R:W151	6.18	No	No	0	9	9
42	R:R:L117	R:R:L68	4.15	No	No	0	9	9
43	R:R:L68	R:R:N316	5.49	No	No	0	9	9
44	R:R:F69	R:R:P317	5.78	Yes	Yes	0	9	9
45	R:R:F69	R:R:P321	2.89	Yes	No	4	9	7
46	R:R:D72	R:R:S313	10.31	No	No	0	9	9
47	R:R:C109	R:R:M74	4.86	No	No	0	6	7
48	R:R:C109	R:R:V75	8.54	No	No	0	6	8
49	R:R:S313	R:R:V75	6.46	No	No	0	9	8
50	R:R:G76	R:R:M80	3.49	No	No	0	7	7
51	R:R:V78	R:R:V79	3.21	No	Yes	0	4	7
52	R:R:F105	R:R:V78	5.24	No	No	0	4	4
53	R:R:V79	R:R:W102	4.9	Yes	Yes	0	7	5
54	R:R:D106	R:R:V79	10.22	No	Yes	0	7	7
55	R:R:C109	R:R:V79	3.42	No	Yes	0	6	7
56	R:R:M80	R:R:Y310	5.99	No	Yes	0	7	7
57	R:R:P81	R:R:P82	5.84	No	No	0	9	4
58	R:R:P82	R:R:W102	8.11	No	Yes	0	4	5
59	R:R:A83	R:R:W307	3.89	No	Yes	0	5	5
60	R:R:N86	R:R:W92	7.91	No	No	0	3	8
61	R:R:N86	R:R:Q179	9.24	No	Yes	0	3	4
62	R:R:L88	R:R:Y89	3.52	No	No	0	5	4
63	R:R:V93	R:R:Y89	3.79	No	No	0	3	4
64	R:R:W102	R:R:W92	4.69	Yes	No	6	5	8
65	R:R:C180	R:R:W92	11.75	No	No	6	9	8
66	R:R:L94	R:R:V93	4.47	No	No	0	5	3
67	R:R:G97	R:R:R96	4.5	No	No	0	3	2
68	R:R:C180	R:R:C99	7.28	No	No	0	9	9
69	R:R:L100	R:R:T103	4.42	No	No	0	4	4
70	R:R:C180	R:R:W102	5.22	No	Yes	6	9	5
71	R:R:L162	R:R:T103	2.95	No	No	0	5	4
72	R:R:L182	R:R:T103	2.95	No	No	0	4	4
73	R:R:A104	R:R:F159	8.32	No	Yes	0	5	4
74	R:R:F105	R:R:F159	6.43	No	Yes	0	4	4
75	R:R:D106	R:R:Y310	12.64	No	Yes	0	7	7
76	R:R:S158	R:R:V107	6.46	No	No	0	7	6
77	R:R:M108	R:R:S111	3.07	Yes	Yes	7	6	7
78	R:R:A155	R:R:M108	3.22	No	Yes	0	4	6
79	R:R:M108	R:R:S158	6.13	Yes	No	7	6	7
80	R:R:F159	R:R:M108	4.98	Yes	Yes	0	4	6
81	R:R:C110	R:R:W281	5.22	No	Yes	0	6	8
82	R:R:A154	R:R:S111	3.42	No	Yes	0	7	7
83	R:R:S111	R:R:S158	3.26	Yes	No	7	7	7
84	R:R:A112	R:R:W151	3.89	No	No	0	7	9
85	R:R:I114	R:R:P200	3.39	No	Yes	0	8	9
86	R:R:F277	R:R:I114	5.02	No	No	1	9	8
87	R:R:I114	R:R:W281	9.4	No	Yes	1	8	8
88	R:R:A150	R:R:L115	3.15	No	No	0	7	5
89	R:R:L115	R:R:L153	4.15	No	No	0	5	4
90	R:R:L117	R:R:Y320	5.86	No	Yes	0	9	9
91	R:R:L119	R:R:L146	5.54	No	No	5	7	6
92	R:R:I120	R:R:R124	5.01	No	No	0	9	9
93	R:R:S121	R:R:T207	6.4	No	No	0	9	7
94	R:R:S121	R:R:Y208	10.17	No	Yes	0	9	9
95	R:R:L122	R:R:T207	2.95	No	No	0	7	7
96	R:R:D123	R:R:Y134	8.05	No	No	0	9	8
97	R:R:F206	R:R:Y125	5.16	No	No	8	5	8
98	R:R:T207	R:R:Y125	6.24	No	No	0	7	8
99	R:R:R210	R:R:Y125	9.26	No	No	8	5	8
100	R:R:L126	R:R:R137	14.58	No	No	0	4	4
101	R:R:L127	R:R:Y134	11.72	No	No	0	8	8
102	R:R:A214	R:R:L129	3.15	No	No	0	6	7
103	R:R:M138	R:R:Y134	10.78	No	No	0	7	8
104	R:R:P140	R:R:T139	3.5	No	No	0	3	8
105	R:R:R142	R:R:T139	14.23	No	No	0	6	8
106	R:R:L144	R:R:L148	5.54	No	No	0	2	3
107	R:R:L156	R:R:S152	3	No	No	0	3	3
108	R:R:F159	R:R:L163	3.65	Yes	No	0	4	4
109	R:R:L160	R:R:P161	8.21	No	No	0	5	5
110	R:R:L160	R:R:W166	4.56	No	No	0	5	4
111	R:R:F188	R:R:P161	2.89	Yes	No	0	7	5
112	R:R:F188	R:R:L162	3.65	Yes	No	0	7	5
113	R:R:L164	R:R:W166	12.53	No	No	0	5	4
114	R:R:H167	R:R:P187	3.05	No	No	0	4	4
115	R:R:F188	R:R:H167	9.05	Yes	No	0	7	4
116	R:R:L169	R:R:S185	3	No	No	0	1	5
117	R:R:H171	R:R:L183	21.86	No	No	0	1	4
118	R:R:P175	R:R:Q179	3.16	No	Yes	0	1	4
119	R:R:P177	R:R:V176	3.53	No	No	0	1	4
120	R:R:Q179	R:R:R181	15.19	Yes	No	0	4	4
121	R:R:P187	R:R:S185	3.56	No	No	0	4	5
122	R:R:A292	R:R:L186	3.15	No	No	0	4	3
123	R:R:A192	R:R:F188	5.55	No	Yes	1	6	7
124	R:R:N288	R:R:V189	2.96	Yes	No	0	6	5
125	R:R:A292	R:R:V189	3.39	No	No	0	4	5
126	R:R:I289	R:R:L190	7.14	No	No	0	6	5
127	R:R:F285	R:R:S193	6.61	Yes	No	1	6	6
128	R:R:F198	R:R:G194	4.52	No	No	0	5	4
129	R:R:F197	R:R:F198	9.65	Yes	No	0	8	5
130	R:R:F197	R:R:S201	7.93	Yes	No	0	8	7
131	R:R:F197	R:R:F277	5.36	Yes	No	0	8	9
132	R:R:F197	R:R:F285	22.51	Yes	Yes	0	8	6
133	R:R:L199	R:R:P200	3.28	No	Yes	0	5	9
134	R:R:F206	R:R:R210	12.83	No	No	8	5	5
135	R:R:L270	R:R:Y208	7.03	No	Yes	0	8	9
136	R:R:L274	R:R:Y208	8.21	No	Yes	0	8	9
137	R:R:L212	R:R:L270	4.15	No	No	0	6	8
138	R:R:Q218	R:R:Q221	5.12	No	No	0	7	4
139	R:R:L273	R:R:T269	2.95	Yes	No	3	8	9
140	R:R:F323	R:R:T269	12.97	No	No	3	7	9
141	R:R:I272	R:R:M276	2.92	No	No	0	7	6
142	R:R:F323	R:R:I272	6.28	No	No	0	7	7
143	R:R:I319	R:R:L273	4.28	No	Yes	3	8	8
144	R:R:L273	R:R:Y320	5.86	Yes	Yes	3	8	9
145	R:R:F323	R:R:L273	7.31	No	Yes	3	7	8
146	R:R:F278	R:R:L274	3.65	No	No	0	5	8
147	R:R:I319	R:R:M276	4.37	No	No	0	8	6
148	R:R:F277	R:R:W281	8.02	No	Yes	1	9	8
149	R:R:N312	R:R:T280	7.31	No	No	0	9	9
150	R:R:F284	R:R:W281	3.01	Yes	Yes	1	7	8
151	R:R:F285	R:R:W281	9.02	Yes	Yes	1	6	8
152	R:R:G309	R:R:W281	8.44	No	Yes	0	6	8
153	R:R:N312	R:R:W281	7.91	No	Yes	0	9	8
154	R:R:F284	R:R:N288	14.5	Yes	Yes	1	7	6
155	R:R:F284	R:R:F302	5.36	Yes	No	1	7	4
156	R:R:F284	R:R:T306	5.19	Yes	No	0	7	4
157	R:R:F302	R:R:N288	4.83	No	Yes	1	4	6
158	R:R:I297	R:R:V290	6.14	No	No	0	5	4
159	R:R:I297	R:R:Q291	12.35	No	No	0	5	3
160	R:R:F302	R:R:Q291	3.51	No	No	0	4	3
161	R:R:C294	R:R:V293	3.42	No	No	0	4	5
162	R:R:C294	R:R:C296	7.28	No	No	0	4	1
163	R:R:T306	R:R:Y310	6.24	No	Yes	0	4	7
164	R:R:W307	R:R:Y310	8.68	Yes	Yes	0	5	7
165	R:R:C311	R:R:T314	6.76	No	No	0	4	6
166	R:R:C311	R:R:M315	3.24	No	No	0	4	6
167	R:R:N316	R:R:P317	3.26	No	Yes	0	9	9
168	R:R:N316	R:R:Y320	15.12	No	Yes	0	9	9
169	R:R:I319	R:R:Y320	6.04	No	Yes	3	8	9
170	R:R:D326	R:R:M324	5.54	Yes	No	2	6	8
171	R:R:F327	R:R:M324	6.22	Yes	No	2	8	8
172	R:R:D326	R:R:F327	3.58	Yes	Yes	2	6	8
173	R:R:P174	R:R:R173	2.88	No	No	0	2	3
174	R:R:I128	R:R:L129	2.85	No	No	0	9	7
175	R:R:I272	R:R:L268	2.85	No	No	0	7	7
176	R:R:C205	R:R:F278	2.79	No	No	0	5	5
177	R:R:A143	R:R:F63	2.77	No	No	0	7	4
178	R:R:L94	R:R:L98	2.77	No	No	0	5	4
179	R:R:L301	R:R:L305	2.77	No	No	0	4	4
180	R:R:L68	R:R:N116	2.75	No	No	0	9	8
181	R:R:K217	R:R:Q221	2.71	No	No	0	5	4
182	R:R:F64	R:R:V147	2.62	Yes	No	0	8	8
183	R:R:R173	R:R:V176	2.62	No	No	0	3	4
184	R:R:D295	R:R:H171	2.52	No	No	0	1	1
185	R:R:M324	R:R:R124	2.48	No	No	0	8	9
186	R:R:S71	R:R:W151	2.47	No	No	0	8	9
187	R:R:F63	R:R:L144	2.44	No	No	0	4	2
188	R:R:F197	R:R:L282	2.44	Yes	No	0	8	6
189	R:R:L213	R:R:R216	2.43	No	No	0	4	5
190	R:R:I204	R:R:Y208	2.42	No	Yes	0	8	9
191	R:R:I211	R:R:Y208	2.42	No	Yes	0	9	9
192	R:R:D303	R:R:W307	2.23	No	Yes	0	3	5
193	R:R:C205	R:R:G202	1.96	No	No	0	5	4
194	R:R:P174	R:R:P175	1.95	No	No	0	2	1
195	R:R:P175	R:R:P177	1.95	No	No	0	1	1
196	R:R:C118	R:R:P200	1.88	No	Yes	0	7	9
197	R:R:G149	R:R:S152	1.86	No	No	0	3	3
198	R:R:G170	R:R:S185	1.86	No	No	0	2	5
199	R:R:G202	R:R:S201	1.86	No	No	0	4	7
200	R:R:A215	R:R:A266	1.79	No	No	0	8	8
201	R:R:P131	R:R:S130	1.78	No	No	0	8	6
202	R:R:P299	R:R:S298	1.78	No	No	0	2	5
203	L:L:?1	R:R:A184	1.77	Yes	No	0	0	4
204	R:R:C294	R:R:V290	1.71	No	No	0	4	4
205	R:R:G309	R:R:L308	1.71	No	No	0	6	7
206	R:R:G332	R:R:L331	1.71	No	No	0	4	7
207	R:R:A143	R:R:T60	1.68	No	No	0	7	6
208	R:R:D303	R:R:G300	1.68	No	No	0	3	1
209	R:R:C52	R:R:I48	1.64	No	No	0	4	8
210	R:R:L115	R:R:P200	1.64	No	Yes	0	5	9
211	R:R:L282	R:R:P283	1.64	No	No	0	6	9
212	R:R:L305	R:R:P283	1.64	No	No	0	4	9
213	R:R:S113	R:R:S71	1.63	No	No	0	9	8
214	R:R:S113	R:R:S313	1.63	No	No	0	9	9
215	R:R:A287	R:R:I297	1.62	No	No	0	4	5
216	R:R:V35	R:R:V36	1.6	No	No	0	5	7
217	R:R:S111	R:R:T196	1.6	Yes	No	0	7	6
218	R:R:T70	R:R:V66	1.59	No	No	0	6	7
219	R:R:C209	R:R:L213	1.59	No	No	0	3	4
220	R:R:T280	R:R:V279	1.59	No	No	0	9	5
221	R:R:A41	R:R:L73	1.58	No	No	0	6	7
222	R:R:A41	R:R:L77	1.58	No	No	0	6	5
223	R:R:A330	R:R:L50	1.58	No	No	0	7	8
224	R:R:A330	R:R:L57	1.58	No	No	0	7	9
225	R:R:A203	R:R:L122	1.58	No	No	0	6	7
226	R:R:A266	R:R:L212	1.58	No	No	0	8	6
227	R:R:A219	R:R:L264	1.58	No	No	0	6	4
228	R:R:A266	R:R:L264	1.58	No	No	0	8	4
229	R:R:I289	R:R:V189	1.54	No	No	0	6	5
230	R:R:I289	R:R:V293	1.54	No	No	0	6	5
231	R:R:A330	R:R:Q54	1.52	No	No	0	7	6
232	R:R:L195	R:R:V191	1.49	No	No	0	3	4
233	R:R:I128	R:R:I211	1.47	No	No	0	9	9
234	R:R:L141	R:R:T139	1.47	No	No	0	4	8
235	R:R:L195	R:R:T196	1.47	No	No	0	3	6
236	R:R:I318	R:R:M315	1.46	No	No	0	7	6
237	R:R:G90	R:R:Y89	1.45	No	No	0	4	4
238	R:R:Q221	R:R:V220	1.43	No	No	0	4	4
239	R:R:L126	R:R:M138	1.41	No	No	0	4	7
240	R:R:C52	R:R:R58	1.39	No	No	0	4	8
241	R:R:L331	R:R:L50	1.38	No	No	0	7	8
242	R:R:L101	R:R:L98	1.38	No	No	0	5	4
243	R:R:E168	R:R:L183	1.33	No	No	0	3	4
244	R:R:R133	R:R:S130	1.32	No	No	0	4	6
245	R:R:D295	R:R:Q291	1.31	No	No	0	1	3
246	R:R:F159	R:R:L101	1.22	Yes	No	0	4	5
247	R:R:D326	R:R:R329	1.19	Yes	No	0	6	4
248	R:R:Q179	R:R:R91	1.17	Yes	No	0	4	4
249	R:R:R133	R:R:R137	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.958	10	1	0
2	R:R:F64	4.5775	4	5	8
3	R:R:F69	6.4325	4	4	9
4	R:R:V79	5.4375	4	0	7
5	R:R:W102	5.73	4	6	5
6	R:R:M108	4.35	4	7	6
7	R:R:S111	2.8375	4	7	7
8	R:R:F159	4.92	5	0	4
9	R:R:Q179	7.19	4	0	4
10	R:R:F188	5.874	5	1	7
11	R:R:F197	9.578	5	0	8
12	R:R:P200	2.5475	4	0	9
13	R:R:Y208	6.05	5	0	9
14	R:R:L273	5.1	4	3	8
15	R:R:W281	7.28857	7	1	8
16	R:R:F284	7.532	5	1	7
17	R:R:F285	10.5625	4	1	6
18	R:R:N288	6.7325	4	1	6
19	R:R:W307	7.4025	4	0	5
20	R:R:Y310	8.3875	4	0	7
21	R:R:P317	4.825	4	0	9
22	R:R:Y320	8.22	4	3	9
23	R:R:D326	3.595	4	2	6
24	R:R:F327	5.82	4	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	94.8796	12.22	Yes	No	0	0	7
2	R:R:D106	R:R:Y310	22.6191	12.64	No	Yes	0	7	7
3	R:R:M80	R:R:Y310	18.4007	5.99	No	Yes	0	7	7
4	R:R:I37	R:R:M80	15.4748	5.83	No	No	0	6	7
5	R:R:I37	R:R:T40	10.9793	6.08	No	No	0	6	7
6	R:R:D106	R:R:V79	100	10.22	No	Yes	0	7	7
7	R:R:C109	R:R:V79	98.7075	3.42	No	Yes	0	6	7
8	R:R:C109	R:R:V75	97.1451	8.54	No	No	0	6	8
9	R:R:S313	R:R:V75	96.3426	6.46	No	No	0	9	8
10	R:R:D72	R:R:S313	61.7002	10.31	No	No	0	9	9
11	R:R:D72	R:R:N44	60.5142	17.5	No	No	0	9	9
12	R:R:N44	R:R:P317	55.8625	6.52	No	Yes	0	9	9
13	R:R:F69	R:R:P317	39.8196	5.78	Yes	Yes	0	9	9
14	R:R:F69	R:R:L65	35.2248	8.53	Yes	No	0	9	8
15	R:R:L65	R:R:N62	33.6695	5.49	No	No	0	8	9
16	R:R:I51	R:R:N62	10.1129	5.66	No	No	2	8	9
17	R:R:F327	R:R:N62	21.9658	8.46	Yes	No	2	8	9
18	R:R:D326	R:R:F327	15.844	3.58	Yes	Yes	2	6	8
19	R:R:D326	R:R:L57	12.5701	4.07	Yes	No	0	6	9
20	R:R:A330	R:R:L57	10.816	1.58	No	No	0	7	9
21	R:R:S113	R:R:S313	35.3526	1.63	No	No	0	9	9
22	R:R:S113	R:R:S71	33.9038	1.63	No	No	0	9	8
23	R:R:S71	R:R:W151	32.6681	2.47	No	No	0	8	9
24	R:R:S67	R:R:W151	30.8927	6.18	No	No	0	9	9
25	R:R:S67	R:R:V147	35.1964	3.23	No	No	0	9	8
26	R:R:F64	R:R:V147	25.1829	2.62	Yes	No	0	8	8
27	R:R:D123	R:R:F64	19.9702	7.17	No	Yes	0	9	8
28	R:R:D123	R:R:Y134	14.7575	8.05	No	No	0	9	8
29	R:R:N116	R:R:S67	10.3899	5.96	No	No	0	8	9
30	R:R:N316	R:R:P317	27.0151	3.26	No	Yes	0	9	9
31	R:R:L68	R:R:N316	10.3473	5.49	No	No	0	9	9
32	R:R:N316	R:R:Y320	19.0398	15.12	No	Yes	0	9	9
33	R:R:V78	R:R:V79	15.8511	3.21	No	Yes	0	4	7
34	R:R:F105	R:R:V78	14.3172	5.24	No	No	0	4	4
35	R:R:V79	R:R:W102	25.6658	4.9	Yes	Yes	0	7	5
36	R:R:W102	R:R:W92	17.4561	4.69	Yes	No	6	5	8
37	R:R:N86	R:R:W92	16.0358	7.91	No	No	0	3	8
38	R:R:N86	R:R:Q179	14.3101	9.24	No	Yes	0	3	4
39	L:L:?1	R:R:V107	22.3209	5.03	Yes	No	0	0	6
40	R:R:S158	R:R:V107	20.7869	6.46	No	No	0	7	6
41	R:R:M108	R:R:S158	10.8728	6.13	Yes	No	7	6	7
42	R:R:F159	R:R:M108	13.9976	4.98	Yes	Yes	0	4	6
43	R:R:F159	R:R:L101	12.3074	1.22	Yes	No	0	4	5
44	R:R:L101	R:R:L98	10.6456	1.38	No	No	0	5	4
45	L:L:?1	R:R:F188	23.3222	8.23	Yes	Yes	1	0	7
46	L:L:?1	R:R:C110	14.516	5.36	Yes	No	0	0	6
47	R:R:C110	R:R:W281	13.6425	5.22	No	Yes	0	6	8
48	L:L:?1	R:R:F284	24.9911	9.6	Yes	Yes	1	0	7
49	R:R:F284	R:R:W281	21.9374	3.01	Yes	Yes	1	7	8
50	L:L:?1	R:R:F285	54.364	4.11	Yes	Yes	1	0	6
51	R:R:F285	R:R:W281	17.236	9.02	Yes	Yes	1	6	8
52	R:R:I114	R:R:W281	21.9658	9.4	No	Yes	1	8	8
53	R:R:I114	R:R:P200	20.2329	3.39	No	Yes	0	8	9
54	R:R:F197	R:R:F285	44.4571	22.51	Yes	Yes	0	8	6
55	R:R:L115	R:R:P200	10.1768	1.64	No	Yes	0	5	9
56	R:R:F197	R:R:S201	39.216	7.93	Yes	No	0	8	7
57	R:R:G202	R:R:S201	37.7317	1.86	No	No	0	4	7
58	R:R:C205	R:R:G202	36.2332	1.96	No	No	0	5	4
59	R:R:C205	R:R:F278	34.7134	2.79	No	No	0	5	5
60	R:R:F278	R:R:L274	33.1866	3.65	No	No	0	5	8
61	R:R:L274	R:R:Y208	31.6313	8.21	No	Yes	0	8	9
62	R:R:S121	R:R:Y208	12.3713	10.17	No	Yes	0	9	9
63	R:R:S121	R:R:T207	10.6456	6.4	No	No	0	9	7
64	R:R:M138	R:R:Y134	11.1995	10.78	No	No	0	7	8
65	R:R:F284	R:R:F302	16.9519	5.36	Yes	No	1	7	4
66	R:R:F302	R:R:Q291	24.9627	3.51	No	No	0	4	3
67	R:R:D295	R:R:Q291	12.5488	1.31	No	No	0	1	3
68	L:L:?1	R:R:N288	21.98	4.64	Yes	Yes	1	0	6
69	R:R:F302	R:R:N288	10.7308	4.83	No	Yes	1	4	6
70	R:R:N288	R:R:V189	12.6411	2.96	Yes	No	0	6	5
71	R:R:L270	R:R:Y208	10.468	7.03	No	Yes	0	8	9
72	R:R:N312	R:R:W281	10.8373	7.91	No	Yes	0	9	8
73	R:R:F105	R:R:F159	12.7832	6.43	No	Yes	0	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	12.22	1	Yes	No	0	7	0	1
L:L:?1	R:R:V107	5.03	1	Yes	No	0	6	0	1
L:L:?1	R:R:C110	5.36	1	Yes	No	0	6	0	1
L:L:?1	R:R:F188	8.23	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:A192	3.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:S193	5.07	1	Yes	No	0	6	0	1
L:L:?1	R:R:F284	9.6	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F285	4.11	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N288	4.64	1	Yes	Yes	0	6	0	1
R:R:D106	R:R:V79	10.22	0	No	Yes	7	7	1	2
R:R:D106	R:R:Y310	12.64	0	No	Yes	7	7	1	2
R:R:S158	R:R:V107	6.46	7	No	No	7	6	2	1
R:R:C110	R:R:W281	5.22	0	No	Yes	6	8	1	2
R:R:F188	R:R:P161	2.89	1	Yes	No	7	5	1	2
R:R:F188	R:R:L162	3.65	1	Yes	No	7	5	1	2
R:R:F188	R:R:H167	9.05	1	Yes	No	7	4	1	2
R:R:A192	R:R:F188	5.55	1	No	Yes	6	7	1	1
R:R:N288	R:R:V189	2.96	1	Yes	No	6	5	1	2
R:R:F285	R:R:S193	6.61	1	Yes	No	6	6	1	1
R:R:F197	R:R:F285	22.51	0	Yes	Yes	8	6	2	1
R:R:F284	R:R:W281	3.01	1	Yes	Yes	7	8	1	2
R:R:F285	R:R:W281	9.02	1	Yes	Yes	6	8	1	2
R:R:F284	R:R:N288	14.5	1	Yes	Yes	7	6	1	1
R:R:F284	R:R:F302	5.36	1	Yes	No	7	4	1	2
R:R:F284	R:R:T306	5.19	1	Yes	No	7	4	1	2
R:R:F302	R:R:N288	4.83	1	No	Yes	4	6	2	1
R:R:T306	R:R:Y310	6.24	0	No	Yes	4	7	2	2
L:L:?1	R:R:A184	1.77	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JLZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	231
Number of Links	249
Number of Hubs	24
Number of Links mediated by Hubs	95
Number of Communities	8
Number of Nodes involved in Communities	36
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	30075
Length Of Smallest Path	3
Average Path Length	13.4137
Length of Longest Path	33
Minimum Path Strength	1.195
Average Path Strength	6.32288
Maximum Path Strength	16.08
Minimum Path Correlation	0.7
Average Path Correlation	0.927177
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	52.3092
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.0907
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • histamine receptor activity • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of TOR signaling • positive regulation of cellular process • TOR signaling • regulation of signaling • regulation of TOR signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • cerebral cortex cell migration • head development • forebrain development • brain development • nervous system development • pallium development • cerebral cortex development • telencephalon cell migration • central nervous system development • forebrain cell migration • cell migration • telencephalon development • cell motility • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UQL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UQL
Name	2-(5-chloranyl-2-methyl-1~{H}-indol-3-yl)-N,N-dimethyl-ethanamine
Synonyms	ST1936
Identifier
Formula	C13 H17 Cl N2
Molecular Weight	236.74
SMILES
PubChem	9921064
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	0
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P50406
Sequence	>8JLZ_nogp_Chain_R G W V A A A L C V V I A L T A A A N S L L I A L I C T Q P A L R N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G R W V L A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S P L R Y K L R M T P L R A L A L V L G A W S L A A L A S F L P L L L G W H E L G H A R P P V P G Q C R L L A S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C D C I S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D F K R A L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JLZ	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	ST1936	-	Gs/β1/γ2	3.09	2023-06-28	doi.org/10.1016/j.bbrc.2023.05.126
	8JLZ (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	ST1936	-		3.09	2023-06-28	doi.org/10.1016/j.bbrc.2023.05.126
	7XTB	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.3	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-		3.3	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7YS6	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-	chim(NtGi1-Gs)/β1/γ2	3	2023-03-29	doi.org/10.1073/pnas.2209917120
	7YS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-		3	2023-03-29	doi.org/10.1073/pnas.2209917120

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