psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L33	R:R:M84	14.14	No	Yes	1	6	5
2	R:R:L33	R:R:W307	5.69	No	Yes	1	6	5
3	R:R:T314	R:R:V36	4.76	No	No	0	6	7
4	R:R:I37	R:R:M80	4.37	No	Yes	0	6	7
5	R:R:I37	R:R:P81	5.08	No	No	0	6	9
6	R:R:N44	R:R:T40	4.39	Yes	No	0	9	7
7	R:R:D72	R:R:N44	14.81	No	Yes	5	9	9
8	R:R:L73	R:R:N44	5.49	No	Yes	0	7	9
9	R:R:N44	R:R:P317	8.15	Yes	No	5	9	9
10	R:R:L47	R:R:L50	2.77	Yes	No	0	9	8
11	R:R:F69	R:R:L47	13.4	Yes	Yes	0	9	9
12	R:R:L47	R:R:P321	4.93	Yes	No	3	9	7
13	R:R:F327	R:R:L47	2.44	Yes	Yes	3	8	9
14	R:R:F69	R:R:I48	2.51	Yes	No	0	9	8
15	R:R:I48	R:R:T70	3.04	No	No	0	8	6
16	R:R:L331	R:R:L50	2.77	No	No	0	7	8
17	R:R:F334	R:R:L50	6.09	Yes	No	0	5	8
18	R:R:I51	R:R:V66	4.61	No	No	0	8	7
19	R:R:F69	R:R:I51	2.51	Yes	No	0	9	8
20	R:R:F327	R:R:I51	5.02	Yes	No	0	8	8
21	R:R:P55	R:R:Q54	6.32	No	No	0	6	6
22	R:R:L57	R:R:Q54	2.66	Yes	No	0	9	6
23	R:R:F334	R:R:Q54	18.74	Yes	No	0	5	6
24	R:R:P55	R:R:R58	7.21	No	No	0	6	8
25	R:R:L57	R:R:N62	2.75	Yes	Yes	3	9	9
26	R:R:D326	R:R:L57	4.07	No	Yes	0	6	9
27	R:R:F327	R:R:L57	4.87	Yes	Yes	3	8	9
28	R:R:N59	R:R:S61	5.96	No	No	0	8	8
29	R:R:N59	R:R:N62	6.81	No	Yes	0	8	9
30	R:R:T60	R:R:Y134	4.99	No	Yes	2	6	8
31	R:R:M138	R:R:T60	4.52	Yes	No	2	7	6
32	R:R:D123	R:R:S61	4.42	Yes	No	0	9	8
33	R:R:L65	R:R:N62	4.12	Yes	Yes	3	8	9
34	R:R:F327	R:R:N62	9.67	Yes	Yes	3	8	9
35	R:R:F63	R:R:V66	3.93	Yes	No	0	4	7
36	R:R:F63	R:R:S67	3.96	Yes	No	2	4	9
37	R:R:F63	R:R:L144	3.65	Yes	No	0	4	2
38	R:R:F63	R:R:V147	7.87	Yes	Yes	2	4	8
39	R:R:F64	R:R:L119	9.74	Yes	No	0	8	7
40	R:R:D123	R:R:F64	9.55	Yes	Yes	2	9	8
41	R:R:F64	R:R:M138	4.98	Yes	Yes	2	8	7
42	R:R:A143	R:R:F64	4.16	No	Yes	0	7	8
43	R:R:F64	R:R:V147	2.62	Yes	Yes	2	8	8
44	R:R:F69	R:R:L65	9.74	Yes	Yes	0	9	8
45	R:R:I120	R:R:L65	2.85	No	Yes	0	9	8
46	R:R:L65	R:R:M324	4.24	Yes	No	0	8	8
47	R:R:F327	R:R:L65	3.65	Yes	Yes	3	8	8
48	R:R:N116	R:R:S67	5.96	Yes	No	2	8	9
49	R:R:S67	R:R:V147	8.08	No	Yes	2	9	8
50	R:R:L68	R:R:N116	2.75	No	Yes	0	9	8
51	R:R:L117	R:R:L68	4.15	No	No	0	9	9
52	R:R:I120	R:R:L68	4.28	No	No	0	9	9
53	R:R:N116	R:R:S71	2.98	Yes	No	2	8	8
54	R:R:S71	R:R:W151	6.18	No	Yes	2	8	9
55	R:R:D72	R:R:S313	5.89	No	No	0	9	9
56	R:R:D72	R:R:P317	6.44	No	No	5	9	9
57	R:R:M74	R:R:V78	3.04	No	No	0	7	4
58	R:R:M108	R:R:M74	2.89	Yes	No	0	6	7
59	R:R:C109	R:R:M74	8.1	No	No	0	6	7
60	R:R:G76	R:R:V75	3.68	No	Yes	0	7	8
61	R:R:V75	R:R:V79	3.21	Yes	Yes	1	8	7
62	R:R:M80	R:R:V75	4.56	Yes	Yes	0	7	8
63	R:R:C109	R:R:V75	3.42	No	Yes	1	6	8
64	R:R:S313	R:R:V75	8.08	No	Yes	0	9	8
65	R:R:F105	R:R:V78	5.24	No	No	0	4	4
66	R:R:D106	R:R:V79	4.38	No	Yes	1	7	7
67	R:R:C109	R:R:V79	3.42	No	Yes	1	6	7
68	R:R:V79	R:R:Y310	3.79	Yes	Yes	1	7	7
69	R:R:M80	R:R:M84	2.89	Yes	Yes	0	7	5
70	R:R:M80	R:R:Y310	3.59	Yes	Yes	0	7	7
71	R:R:P81	R:R:P82	5.84	No	No	0	9	4
72	R:R:P82	R:R:W92	2.7	No	Yes	4	4	8
73	R:R:P82	R:R:W102	12.16	No	No	4	4	5
74	R:R:A83	R:R:M84	3.22	No	Yes	0	5	5
75	R:R:A83	R:R:Y310	5.34	No	Yes	0	5	7
76	R:R:M84	R:R:W307	5.82	Yes	Yes	1	5	5
77	R:R:N86	R:R:W92	6.78	No	Yes	0	3	8
78	R:R:A87	R:R:W307	2.59	No	Yes	0	4	5
79	R:R:V93	R:R:Y89	8.83	No	No	0	3	4
80	R:R:R91	R:R:V93	9.15	No	No	0	4	3
81	R:R:Q179	R:R:R91	3.5	No	No	0	4	4
82	R:R:C99	R:R:W92	7.84	No	Yes	4	9	8
83	R:R:W102	R:R:W92	12.18	No	Yes	4	5	8
84	R:R:C180	R:R:W92	3.92	No	Yes	4	9	8
85	R:R:A95	R:R:L98	3.15	No	No	0	7	4
86	R:R:L101	R:R:L98	2.77	No	No	0	5	4
87	R:R:C180	R:R:C99	5.46	No	No	4	9	9
88	R:R:F105	R:R:L101	2.44	No	No	0	4	5
89	R:R:C180	R:R:W102	5.22	No	No	4	9	5
90	R:R:L162	R:R:T103	4.42	Yes	No	0	5	4
91	R:R:L182	R:R:T103	8.84	No	No	0	4	4
92	R:R:A104	R:R:F159	2.77	No	Yes	0	5	4
93	R:R:A104	R:R:L162	3.15	No	Yes	0	5	5
94	R:R:F105	R:R:F159	5.36	No	Yes	0	4	4
95	R:R:D106	R:R:Y310	11.49	No	Yes	1	7	7
96	L:L:?1	R:R:D106	8.08	Yes	No	1	0	7
97	R:R:S158	R:R:V107	3.23	No	No	0	7	6
98	R:R:L162	R:R:V107	2.98	Yes	No	0	5	6
99	L:L:?1	R:R:V107	7.6	Yes	No	0	0	6
100	R:R:M108	R:R:S158	6.13	Yes	No	6	6	7
101	R:R:F159	R:R:M108	4.98	Yes	Yes	6	4	6
102	R:R:C110	R:R:W281	3.92	No	Yes	0	6	8
103	L:L:?1	R:R:C110	10.8	Yes	No	0	0	6
104	R:R:S111	R:R:T196	7.99	No	No	1	7	6
105	L:L:?1	R:R:S111	2.55	Yes	No	1	0	7
106	R:R:A112	R:R:W151	7.78	No	Yes	0	7	9
107	R:R:F197	R:R:I114	2.51	Yes	Yes	1	8	8
108	R:R:I114	R:R:P200	3.39	Yes	Yes	0	8	9
109	R:R:F277	R:R:I114	3.77	Yes	Yes	1	9	8
110	R:R:I114	R:R:W281	5.87	Yes	Yes	1	8	8
111	R:R:F285	R:R:I114	2.51	Yes	Yes	1	6	8
112	R:R:N116	R:R:W151	6.78	Yes	Yes	2	8	9
113	R:R:F277	R:R:L117	2.44	Yes	No	0	9	9
114	R:R:L117	R:R:Y320	3.52	No	No	0	9	9
115	R:R:C118	R:R:P200	7.53	No	Yes	0	7	9
116	R:R:A150	R:R:L119	3.15	No	No	0	7	7
117	R:R:I120	R:R:R124	3.76	No	No	0	9	9
118	R:R:I204	R:R:S121	4.64	No	No	0	8	9
119	R:R:S121	R:R:T207	6.4	No	No	7	9	7
120	R:R:S121	R:R:Y208	5.09	No	Yes	7	9	9
121	R:R:D123	R:R:Y134	4.6	Yes	Yes	2	9	8
122	R:R:D123	R:R:M138	2.77	Yes	Yes	2	9	7
123	R:R:I128	R:R:R124	2.51	No	No	0	9	9
124	R:R:M324	R:R:R124	7.44	No	No	0	8	9
125	R:R:L129	R:R:Y125	5.86	No	Yes	0	7	8
126	R:R:T207	R:R:Y125	7.49	No	Yes	0	7	8
127	R:R:R210	R:R:Y125	5.14	No	Yes	0	5	8
128	R:R:L126	R:R:M138	2.83	No	Yes	0	4	7
129	R:R:L127	R:R:Y134	12.89	No	Yes	0	8	8
130	R:R:I128	R:R:L129	2.85	No	No	0	9	7
131	R:R:I128	R:R:I211	2.94	No	No	0	9	9
132	R:R:A214	R:R:L129	3.15	No	No	0	6	7
133	R:R:R133	R:R:S130	2.64	Yes	No	8	4	6
134	R:R:R137	R:R:S130	5.27	No	No	8	4	6
135	R:R:L136	R:R:R133	3.64	No	Yes	0	4	4
136	R:R:R133	R:R:R137	7.46	Yes	No	8	4	4
137	R:R:K135	R:R:Y134	3.58	No	Yes	0	4	8
138	R:R:M138	R:R:Y134	13.17	Yes	Yes	2	7	8
139	R:R:P140	R:R:T139	3.5	No	No	0	3	8
140	R:R:L141	R:R:T139	2.95	No	No	0	4	8
141	R:R:R142	R:R:T139	10.35	No	No	0	6	8
142	R:R:L144	R:R:L148	4.15	No	No	0	2	3
143	R:R:V147	R:R:W151	2.45	Yes	Yes	2	8	9
144	R:R:L156	R:R:L160	6.92	No	No	0	3	5
145	R:R:F159	R:R:S158	6.61	Yes	No	6	4	7
146	R:R:F159	R:R:L163	3.65	Yes	No	0	4	4
147	R:R:F188	R:R:P161	7.22	Yes	No	0	7	5
148	R:R:H167	R:R:L162	10.29	Yes	Yes	0	4	5
149	R:R:G165	R:R:H167	3.18	No	Yes	0	4	4
150	R:R:E168	R:R:H167	13.54	No	Yes	0	3	4
151	R:R:F188	R:R:H167	5.66	Yes	Yes	0	7	4
152	R:R:E168	R:R:H171	11.08	No	No	9	3	1
153	R:R:E168	R:R:L183	7.95	No	No	9	3	4
154	R:R:H171	R:R:L183	5.14	No	No	9	1	4
155	R:R:P174	R:R:R173	2.88	No	No	0	2	3
156	R:R:Q291	R:R:R173	10.51	No	No	0	3	3
157	R:R:P177	R:R:V176	3.53	No	No	0	1	4
158	R:R:Q179	R:R:V176	4.3	No	No	0	4	4
159	R:R:G178	R:R:Q179	3.29	No	No	0	4	4
160	R:R:Q291	R:R:R181	5.84	No	No	0	3	4
161	R:R:F302	R:R:R181	3.21	Yes	No	0	4	4
162	L:L:?1	R:R:L182	4.71	Yes	No	0	0	4
163	R:R:A184	R:R:F188	2.77	No	Yes	0	4	7
164	R:R:L186	R:R:P187	3.28	Yes	No	0	3	4
165	R:R:L186	R:R:L190	2.77	Yes	No	0	3	5
166	R:R:A292	R:R:L186	4.73	No	Yes	0	4	3
167	R:R:L186	R:R:V293	11.92	Yes	No	0	3	5
168	R:R:A192	R:R:F188	4.16	No	Yes	0	6	7
169	R:R:I289	R:R:V189	3.07	No	No	0	6	5
170	R:R:A292	R:R:V189	5.09	No	No	0	4	5
171	L:L:?1	R:R:A192	2.68	Yes	No	0	0	6
172	R:R:F198	R:R:S193	5.28	No	No	0	5	6
173	R:R:F285	R:R:S193	2.64	Yes	No	0	6	6
174	R:R:F198	R:R:G194	4.52	No	No	0	5	4
175	L:L:?1	R:R:T196	5.01	Yes	No	1	0	6
176	R:R:F197	R:R:F198	10.72	Yes	No	0	8	5
177	R:R:F197	R:R:S201	2.64	Yes	No	0	8	7
178	R:R:F197	R:R:F277	7.5	Yes	Yes	1	8	9
179	R:R:F197	R:R:W281	3.01	Yes	Yes	1	8	8
180	R:R:F197	R:R:L282	2.44	Yes	No	0	8	6
181	R:R:F197	R:R:F285	11.79	Yes	Yes	1	8	6
182	R:R:L199	R:R:P200	3.28	No	Yes	0	5	9
183	R:R:F278	R:R:S201	7.93	Yes	No	0	5	7
184	R:R:C205	R:R:F278	2.79	No	Yes	0	5	5
185	R:R:F206	R:R:R210	7.48	No	No	0	5	5
186	R:R:T207	R:R:Y208	2.5	No	Yes	7	7	9
187	R:R:L270	R:R:Y208	8.21	No	Yes	0	8	9
188	R:R:L274	R:R:Y208	5.86	No	Yes	0	8	9
189	R:R:C209	R:R:L213	3.17	No	No	0	3	4
190	R:R:L212	R:R:R216	9.72	No	No	0	6	5
191	R:R:L212	R:R:L270	2.77	No	No	0	6	8
192	R:R:L225	R:R:S224	3	No	No	0	4	4
193	R:R:I272	R:R:L268	4.28	No	No	0	7	7
194	R:R:F323	R:R:T269	10.38	Yes	No	0	7	9
195	R:R:F323	R:R:I272	3.77	Yes	No	0	7	7
196	R:R:L273	R:R:Y320	4.69	No	No	0	8	9
197	R:R:F278	R:R:L274	2.44	Yes	No	0	5	8
198	R:R:I319	R:R:M276	5.83	No	No	0	8	6
199	R:R:F277	R:R:F278	15	Yes	Yes	0	9	5
200	R:R:F277	R:R:W281	6.01	Yes	Yes	1	9	8
201	R:R:T280	R:R:W281	3.64	No	Yes	1	9	8
202	R:R:N312	R:R:T280	11.7	No	No	1	9	9
203	R:R:F284	R:R:W281	3.01	Yes	Yes	1	7	8
204	R:R:F285	R:R:W281	3.01	Yes	Yes	1	6	8
205	R:R:G309	R:R:W281	8.44	No	Yes	0	6	8
206	R:R:N312	R:R:W281	9.04	No	Yes	1	9	8
207	R:R:L282	R:R:P283	3.28	No	No	0	6	9
208	R:R:F284	R:R:F302	7.5	Yes	Yes	1	7	4
209	R:R:F284	R:R:L305	2.44	Yes	No	0	7	4
210	R:R:F284	R:R:T306	9.08	Yes	No	1	7	4
211	L:L:?1	R:R:F284	4.14	Yes	Yes	1	0	7
212	L:L:?1	R:R:F285	8.29	Yes	Yes	1	0	6
213	R:R:F302	R:R:N288	4.83	Yes	No	0	4	6
214	L:L:?1	R:R:N288	9.34	Yes	No	0	0	6
215	R:R:I297	R:R:V290	3.07	No	No	0	5	4
216	R:R:I297	R:R:Q291	8.23	No	No	0	5	3
217	R:R:D303	R:R:G300	5.03	No	No	0	3	1
218	R:R:F302	R:R:T306	5.19	Yes	No	1	4	4
219	R:R:T306	R:R:Y310	4.99	No	Yes	1	4	7
220	R:R:W307	R:R:Y310	2.89	Yes	Yes	1	5	7
221	R:R:C311	R:R:M315	3.24	No	No	0	4	6
222	R:R:N312	R:R:N316	13.62	No	No	0	9	9
223	R:R:M315	R:R:T314	6.02	No	No	0	6	6
224	R:R:I318	R:R:M315	2.92	No	No	0	7	6
225	R:R:I318	R:R:I319	2.94	No	No	0	7	8
226	R:R:F323	R:R:I319	3.77	Yes	No	0	7	8
227	R:R:P321	R:R:Y320	2.78	No	No	0	7	9
228	R:R:F327	R:R:P321	4.33	Yes	No	3	8	7
229	R:R:F323	R:R:L322	8.53	Yes	No	0	7	5
230	R:R:K328	R:R:R325	9.9	No	No	0	9	5
231	R:R:R325	R:R:R329	13.86	No	No	0	5	4
232	R:R:A330	R:R:F334	2.77	No	Yes	0	7	5
233	R:R:L213	R:R:R216	2.43	No	No	0	4	5
234	R:R:L88	R:R:Y89	2.34	No	No	0	5	4
235	R:R:L122	R:R:Y125	2.34	No	Yes	0	7	8
236	R:R:R96	R:R:W92	2	No	Yes	0	2	8
237	R:R:C205	R:R:G202	1.96	No	No	0	5	4
238	R:R:P174	R:R:P175	1.95	No	No	0	2	1
239	R:R:G149	R:R:S152	1.86	No	No	0	3	3
240	R:R:A203	R:R:C118	1.81	No	No	0	6	7
241	R:R:A112	R:R:A154	1.79	No	No	0	7	7
242	R:R:A215	R:R:A266	1.79	No	No	0	8	8
243	R:R:P131	R:R:S130	1.78	No	No	0	8	6
244	R:R:P187	R:R:S185	1.78	No	No	0	4	5
245	R:R:P299	R:R:S298	1.78	No	No	0	2	5
246	R:R:G275	R:R:L274	1.71	No	No	0	5	8
247	R:R:A184	R:R:V189	1.7	No	No	0	4	5
248	R:R:L115	R:R:P200	1.64	No	Yes	0	5	9
249	R:R:L160	R:R:P161	1.64	No	No	0	5	5
250	R:R:L335	R:R:P336	1.64	No	No	0	6	5
251	R:R:S113	R:R:S71	1.63	No	No	0	9	8
252	R:R:A155	R:R:M108	1.61	No	Yes	0	4	6
253	R:R:T226	R:R:V222	1.59	No	No	0	3	6
254	R:R:T280	R:R:V279	1.59	No	No	0	9	5
255	R:R:A266	R:R:L270	1.58	No	No	0	8	8
256	R:R:A287	R:R:L305	1.58	No	No	0	4	4
257	R:R:C296	R:R:D295	1.56	No	No	0	1	1
258	R:R:M276	R:R:V279	1.52	No	No	0	6	5
259	R:R:L46	R:R:S45	1.5	No	No	0	7	4
260	R:R:G90	R:R:R91	1.5	No	No	0	4	4
261	R:R:G178	R:R:R96	1.5	No	No	0	4	2
262	R:R:L212	R:R:S267	1.5	No	No	0	6	7
263	R:R:K265	R:R:T269	1.5	No	No	0	8	9
264	R:R:L301	R:R:S298	1.5	No	No	0	4	5
265	R:R:L39	R:R:V36	1.49	No	No	0	5	7
266	R:R:L77	R:R:V78	1.49	No	No	0	5	4
267	R:R:L94	R:R:V93	1.49	No	No	0	5	3
268	R:R:L225	R:R:T226	1.47	No	No	0	4	3
269	R:R:Q218	R:R:V222	1.43	No	No	0	7	6
270	R:R:L331	R:R:L335	1.38	No	No	0	7	6
271	R:R:K217	R:R:Q221	1.36	No	No	0	5	4
272	R:R:P161	R:R:W166	1.35	No	No	0	5	4
273	R:R:F334	R:R:T53	1.3	Yes	No	0	5	6
274	R:R:Q218	R:R:Q221	1.28	No	No	0	7	4
275	R:R:F64	R:R:L146	1.22	Yes	No	0	8	6
276	R:R:L132	R:R:R133	1.21	No	Yes	0	7	4
277	R:R:D295	R:R:R173	1.19	No	No	0	1	3
278	R:R:D303	R:R:F302	1.19	No	Yes	0	3	4
279	R:R:D326	R:R:R325	1.19	No	No	0	6	5
280	R:R:L85	R:R:Y89	1.17	No	No	0	5	4
281	R:R:L164	R:R:W166	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N44	8.21	4	5	9
2	R:R:L47	5.885	4	3	9
3	R:R:L57	3.5875	4	3	9
4	R:R:N62	5.8375	4	3	9
5	R:R:F63	4.8525	4	2	4
6	R:R:F64	5.37833	6	2	8
7	R:R:L65	4.92	5	3	8
8	R:R:F69	7.04	4	0	9
9	R:R:V75	4.59	5	1	8
10	R:R:V79	3.7	4	1	7
11	R:R:M80	3.8525	4	0	7
12	R:R:M84	6.5175	4	1	5
13	R:R:W92	5.90333	6	4	8
14	R:R:M108	3.9025	4	6	6
15	R:R:I114	3.61	5	1	8
16	R:R:N116	4.6175	4	2	8
17	R:R:D123	5.335	4	2	9
18	R:R:Y125	5.2075	4	0	8
19	R:R:R133	3.7375	4	8	4
20	R:R:Y134	7.846	5	2	8
21	R:R:M138	5.654	5	2	7
22	R:R:V147	5.255	4	2	8
23	R:R:W151	5.7975	4	2	9
24	R:R:F159	4.674	5	6	4
25	R:R:L162	5.21	4	0	5
26	R:R:H167	8.1675	4	0	4
27	R:R:L186	5.675	4	0	3
28	R:R:F188	4.9525	4	0	7
29	R:R:F197	5.80143	7	1	8
30	R:R:P200	3.96	4	0	9
31	R:R:Y208	5.415	4	7	9
32	R:R:F277	6.944	5	1	9
33	R:R:F278	7.04	4	0	5
34	R:R:W281	5.10556	9	1	8
35	R:R:F284	5.234	5	1	7
36	R:R:F285	5.648	5	1	6
37	R:R:F302	4.384	5	1	4
38	R:R:W307	4.2475	4	1	5
39	R:R:Y310	5.34833	6	1	7
40	R:R:F323	6.6125	4	0	7
41	R:R:F327	4.99667	6	3	8
42	R:R:F334	7.225	4	0	5
43	L:L:?1	6.32	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T306	R:R:Y310	20.3968	4.99	No	Yes	1	4	7
2	R:R:F284	R:R:T306	19.0759	9.08	Yes	No	1	7	4
3	R:R:F284	R:R:W281	46.0428	3.01	Yes	Yes	1	7	8
4	R:R:T280	R:R:W281	15.9809	3.64	No	Yes	1	9	8
5	R:R:T280	R:R:V279	15.0873	1.59	No	No	0	9	5
6	R:R:M276	R:R:V279	14.1045	1.52	No	No	0	6	5
7	R:R:I319	R:R:M276	13.1113	5.83	No	No	0	8	6
8	R:R:I37	R:R:M80	13.5411	4.37	No	Yes	0	6	7
9	R:R:I37	R:R:P81	12.9409	5.08	No	No	0	6	9
10	R:R:S313	R:R:V75	16.4448	8.08	No	Yes	0	9	8
11	R:R:D72	R:R:S313	13.7167	5.89	No	No	0	9	9
12	R:R:F277	R:R:W281	80.8847	6.01	Yes	Yes	1	9	8
13	R:R:F277	R:R:L117	100	2.44	Yes	No	0	9	9
14	R:R:L117	R:R:Y320	32.237	3.52	No	No	0	9	9
15	R:R:P321	R:R:Y320	29.9885	2.78	No	No	0	7	9
16	R:R:L47	R:R:P321	12.6893	4.93	Yes	No	3	9	7
17	R:R:I120	R:R:L65	11.932	2.85	No	Yes	0	9	8
18	R:R:I120	R:R:L68	18.4889	4.28	No	No	0	9	9
19	R:R:L117	R:R:L68	67.4931	4.15	No	No	0	9	9
20	R:R:F327	R:R:P321	16.2849	4.33	Yes	No	3	8	7
21	R:R:L68	R:R:N116	51.1662	2.75	No	Yes	0	9	8
22	R:R:N116	R:R:S67	24.582	5.96	Yes	No	2	8	9
23	R:R:F327	R:R:L57	10.826	4.87	Yes	Yes	3	8	9
24	R:R:S67	R:R:V147	18.7222	8.08	No	Yes	2	9	8
25	R:R:F64	R:R:V147	35.6622	2.62	Yes	Yes	2	8	8
26	R:R:F64	R:R:M138	14.2513	4.98	Yes	Yes	2	8	7
27	R:R:N116	R:R:W151	22.7082	6.78	Yes	Yes	2	8	9
28	R:R:V147	R:R:W151	19.2201	2.45	Yes	Yes	2	8	9
29	R:R:P81	R:R:P82	12.3356	5.84	No	No	0	9	4
30	R:R:P82	R:R:W92	10.4827	2.7	No	Yes	4	4	8
31	R:R:L162	R:R:V107	13.3995	2.98	Yes	No	0	5	6
32	L:L:?1	R:R:V107	40.4843	7.6	Yes	No	0	0	6
33	L:L:?1	R:R:D106	29.3385	8.08	Yes	No	1	0	7
34	R:R:F159	R:R:S158	14.5029	6.61	Yes	No	6	4	7
35	R:R:S158	R:R:V107	25.7063	3.23	No	No	0	7	6
36	L:L:?1	R:R:C110	21.8722	10.8	Yes	No	0	0	6
37	R:R:F197	R:R:F285	24.2308	11.79	Yes	Yes	1	8	6
38	L:L:?1	R:R:F285	65.9023	8.29	Yes	Yes	1	0	6
39	R:R:F285	R:R:I114	20.2972	2.51	Yes	Yes	1	6	8
40	R:R:L274	R:R:Y208	25.6722	5.86	No	Yes	0	8	9
41	R:R:F278	R:R:L274	28.6126	2.44	Yes	No	0	5	8
42	R:R:F277	R:R:F278	28.838	15	Yes	Yes	0	9	5
43	R:R:F188	R:R:P161	10.1525	7.22	Yes	No	0	7	5
44	R:R:A192	R:R:F188	38.7494	4.16	No	Yes	0	6	7
45	L:L:?1	R:R:A192	40.6704	2.68	Yes	No	0	0	6
46	R:R:H167	R:R:L162	10.6426	10.29	Yes	Yes	0	4	5
47	R:R:F188	R:R:H167	10.564	5.66	Yes	Yes	0	7	4
48	R:R:E168	R:R:H167	11.8376	13.54	No	Yes	0	3	4
49	R:R:A184	R:R:F188	18.1823	2.77	No	Yes	0	4	7
50	R:R:A292	R:R:L186	10.1525	4.73	No	Yes	0	4	3
51	R:R:A292	R:R:V189	12.1678	5.09	No	No	0	4	5
52	R:R:A184	R:R:V189	16.1827	1.7	No	No	0	4	5
53	R:R:L270	R:R:Y208	12.6527	8.21	No	Yes	0	8	9
54	R:R:M80	R:R:Y310	16.2823	3.59	Yes	Yes	0	7	7
55	R:R:V75	R:R:V79	17.8993	3.21	Yes	Yes	1	8	7
56	R:R:D106	R:R:V79	23.6176	4.38	No	Yes	1	7	7
57	R:R:C110	R:R:W281	21.9744	3.92	No	Yes	0	6	8
58	L:L:?1	R:R:F284	23.6412	4.14	Yes	Yes	1	0	7
59	R:R:F285	R:R:W281	22.3308	3.01	Yes	Yes	1	6	8
60	R:R:F105	R:R:F159	11.2506	5.36	No	Yes	0	4	4
61	R:R:F277	R:R:I114	20.5724	3.77	Yes	Yes	1	9	8
62	R:R:F197	R:R:F277	20.8449	7.5	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D106	R:R:V79	4.38	1	No	Yes	7	7	1	2
R:R:V79	R:R:Y310	3.79	1	Yes	Yes	7	7	2	2
R:R:L162	R:R:T103	4.42	0	Yes	No	5	4	2	2
R:R:L182	R:R:T103	8.84	0	No	No	4	4	1	2
R:R:D106	R:R:Y310	11.49	1	No	Yes	7	7	1	2
L:L:?1	R:R:D106	8.08	1	Yes	No	0	7	0	1
R:R:S158	R:R:V107	3.23	6	No	No	7	6	2	1
R:R:L162	R:R:V107	2.98	0	Yes	No	5	6	2	1
L:L:?1	R:R:V107	7.6	1	Yes	No	0	6	0	1
R:R:C110	R:R:W281	3.92	0	No	Yes	6	8	1	2
L:L:?1	R:R:C110	10.8	1	Yes	No	0	6	0	1
R:R:S111	R:R:T196	7.99	1	No	No	7	6	1	1
L:L:?1	R:R:S111	2.55	1	Yes	No	0	7	0	1
R:R:F197	R:R:I114	2.51	1	Yes	Yes	8	8	2	2
R:R:I114	R:R:W281	5.87	1	Yes	Yes	8	8	2	2
R:R:F285	R:R:I114	2.51	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:L182	4.71	1	Yes	No	0	4	0	1
R:R:A192	R:R:F188	4.16	0	No	Yes	6	7	1	2
L:L:?1	R:R:A192	2.68	1	Yes	No	0	6	0	1
R:R:F285	R:R:S193	2.64	1	Yes	No	6	6	1	2
L:L:?1	R:R:T196	5.01	1	Yes	No	0	6	0	1
R:R:F197	R:R:W281	3.01	1	Yes	Yes	8	8	2	2
R:R:F197	R:R:F285	11.79	1	Yes	Yes	8	6	2	1
R:R:F284	R:R:W281	3.01	1	Yes	Yes	7	8	1	2
R:R:F285	R:R:W281	3.01	1	Yes	Yes	6	8	1	2
R:R:F284	R:R:F302	7.5	1	Yes	Yes	7	4	1	2
R:R:F284	R:R:L305	2.44	1	Yes	No	7	4	1	2
R:R:F284	R:R:T306	9.08	1	Yes	No	7	4	1	2
L:L:?1	R:R:F284	4.14	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F285	8.29	1	Yes	Yes	0	6	0	1
R:R:F302	R:R:N288	4.83	1	Yes	No	4	6	2	1
L:L:?1	R:R:N288	9.34	1	Yes	No	0	6	0	1
R:R:F302	R:R:T306	5.19	1	Yes	No	4	4	2	2
R:R:T306	R:R:Y310	4.99	1	No	Yes	4	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YS6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	238
Number of Links	281
Number of Hubs	43
Number of Links mediated by Hubs	162
Number of Communities	9
Number of Nodes involved in Communities	58
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	68039
Length Of Smallest Path	3
Average Path Length	12.6533
Length of Longest Path	26
Minimum Path Strength	1.245
Average Path Strength	5.07902
Maximum Path Strength	13.03
Minimum Path Correlation	0.7
Average Path Correlation	0.919674
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	44.3588
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0861
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • serotonin receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of TOR signaling • positive regulation of cellular process • TOR signaling • regulation of signaling • regulation of TOR signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • cerebral cortex cell migration • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • pallium development • cerebral cortex development • multicellular organism development • telencephalon cell migration • central nervous system development • forebrain cell migration • anatomical structure development • cell migration • telencephalon development • cell motility • system development • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • dendrite • dendritic tree
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • dendrite • dendritic tree • neuron projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	Serotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P50406
Sequence	>7YS6_nogp_Chain_R A A L C V V I A L T A A A N S L L I A L I C T Q P A L R N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G R W V L A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S P L R Y K L R M T P L R A L A L V L G A W S L A A L A S F L P L L L G W H E L G H A R P P V P G Q C R L L A S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C D C I S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D F K R A L G R F L P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JLZ	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	ST1936	-	Gs/β1/γ2	3.09	2023-06-28	10.1016/j.bbrc.2023.05.126
	8JLZ (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	ST1936	-		3.09	2023-06-28	10.1016/j.bbrc.2023.05.126
	7YS6	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-	chim(NtGi1-Gs)/β1/γ2	3	2023-03-29	10.1073/pnas.2209917120
	7YS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-		3	2023-03-29	10.1073/pnas.2209917120
	7XTB	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.3	2022-07-27	10.1016/j.molcel.2022.05.031
	7XTB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-		3.3	2022-07-27	10.1016/j.molcel.2022.05.031

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