psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S26	R:R:V29	3.23	No	No	0	4	5
2	R:R:A30	R:R:L88	4.73	No	No	0	6	5
3	R:R:L33	R:R:W307	7.97	No	Yes	0	6	5
4	R:R:I37	R:R:M80	10.2	No	Yes	0	6	7
5	R:R:I37	R:R:P81	3.39	No	No	0	6	9
6	R:R:N44	R:R:T40	4.39	Yes	No	1	9	7
7	R:R:T314	R:R:T40	14.13	No	No	1	6	7
8	R:R:D72	R:R:N44	4.04	Yes	Yes	1	9	9
9	R:R:L73	R:R:N44	8.24	Yes	Yes	0	7	9
10	R:R:N44	R:R:P317	6.52	Yes	Yes	1	9	9
11	R:R:L73	R:R:S45	3	Yes	No	0	7	4
12	R:R:F69	R:R:L47	10.96	Yes	No	0	9	9
13	R:R:L47	R:R:P321	4.93	No	No	0	9	7
14	R:R:I48	R:R:L73	4.28	No	Yes	0	8	7
15	R:R:L50	R:R:Q54	7.99	No	Yes	0	8	6
16	R:R:L331	R:R:L50	2.77	No	No	0	7	8
17	R:R:I51	R:R:V66	6.14	No	No	0	8	7
18	R:R:F69	R:R:I51	2.51	Yes	No	0	9	8
19	R:R:F327	R:R:I51	5.02	Yes	No	0	8	8
20	R:R:Q54	R:R:T53	2.83	Yes	No	0	6	6
21	R:R:L57	R:R:Q54	6.65	Yes	Yes	0	9	6
22	R:R:A330	R:R:Q54	4.55	No	Yes	0	7	6
23	R:R:Q54	R:R:R333	8.18	Yes	No	0	6	3
24	R:R:L57	R:R:N62	2.75	Yes	No	3	9	9
25	R:R:F327	R:R:L57	7.31	Yes	Yes	3	8	9
26	R:R:N59	R:R:N62	10.9	No	No	0	8	9
27	R:R:T60	R:R:Y134	2.5	No	Yes	0	6	8
28	R:R:D123	R:R:S61	7.36	Yes	No	2	9	8
29	R:R:S61	R:R:Y134	3.82	No	Yes	2	8	8
30	R:R:F327	R:R:N62	3.62	Yes	No	3	8	9
31	R:R:F63	R:R:L144	2.44	No	No	0	4	2
32	R:R:F63	R:R:V147	5.24	No	No	0	4	8
33	R:R:F64	R:R:L119	4.87	Yes	No	0	8	7
34	R:R:F64	R:R:I120	3.77	Yes	Yes	0	8	9
35	R:R:D123	R:R:F64	10.75	Yes	Yes	0	9	8
36	R:R:A143	R:R:F64	2.77	No	Yes	0	7	8
37	R:R:F64	R:R:V147	2.62	Yes	No	0	8	8
38	R:R:F69	R:R:L65	3.65	Yes	Yes	0	9	8
39	R:R:I120	R:R:L65	2.85	Yes	Yes	0	9	8
40	R:R:L65	R:R:Y320	3.52	Yes	Yes	0	8	9
41	R:R:L65	R:R:M324	2.83	Yes	No	0	8	8
42	R:R:N116	R:R:S67	4.47	No	No	1	8	9
43	R:R:S67	R:R:W151	3.71	No	Yes	1	9	9
44	R:R:D72	R:R:L68	2.71	Yes	Yes	1	9	9
45	R:R:L68	R:R:N116	8.24	Yes	No	1	9	8
46	R:R:L117	R:R:L68	4.15	Yes	Yes	1	9	9
47	R:R:I120	R:R:L68	4.28	Yes	Yes	0	9	9
48	R:R:L68	R:R:N316	4.12	Yes	Yes	1	9	9
49	R:R:F69	R:R:P317	2.89	Yes	Yes	0	9	9
50	R:R:S71	R:R:W151	4.94	No	Yes	0	8	9
51	R:R:D72	R:R:S313	5.89	Yes	No	0	9	9
52	R:R:D72	R:R:P317	8.05	Yes	Yes	1	9	9
53	R:R:L73	R:R:L77	5.54	Yes	No	0	7	5
54	R:R:M74	R:R:V78	4.56	No	No	0	7	4
55	R:R:C109	R:R:M74	3.24	No	No	0	6	7
56	R:R:C109	R:R:V75	5.12	No	No	0	6	8
57	R:R:G76	R:R:M80	5.24	No	Yes	0	7	7
58	R:R:V78	R:R:V79	3.21	No	Yes	0	4	7
59	R:R:V79	R:R:W102	4.9	Yes	No	0	7	5
60	R:R:D106	R:R:V79	7.3	No	Yes	1	7	7
61	R:R:V79	R:R:Y310	3.79	Yes	Yes	1	7	7
62	R:R:M80	R:R:Y310	3.59	Yes	Yes	0	7	7
63	R:R:M80	R:R:T314	3.01	Yes	No	0	7	6
64	R:R:P81	R:R:P82	7.79	No	No	0	9	4
65	R:R:P82	R:R:W102	8.11	No	No	0	4	5
66	R:R:A83	R:R:W307	2.59	No	Yes	0	5	5
67	R:R:L88	R:R:M84	2.83	No	No	0	5	5
68	R:R:L85	R:R:Y89	11.72	No	No	0	5	4
69	R:R:N86	R:R:W92	5.65	No	Yes	0	3	8
70	R:R:A87	R:R:W307	2.59	No	Yes	0	4	5
71	R:R:V93	R:R:Y89	3.79	No	No	0	3	4
72	R:R:L94	R:R:W92	11.39	No	Yes	0	5	8
73	R:R:C99	R:R:W92	6.53	No	Yes	0	9	8
74	R:R:L94	R:R:L98	8.3	No	No	0	5	4
75	R:R:G178	R:R:R96	3	No	No	0	4	2
76	R:R:C180	R:R:C99	7.28	No	No	0	9	9
77	R:R:L100	R:R:L162	6.92	No	No	0	4	5
78	R:R:F105	R:R:L101	2.44	No	No	0	4	5
79	R:R:T103	R:R:W102	4.85	No	No	0	4	5
80	R:R:L182	R:R:T103	2.95	No	No	0	4	4
81	R:R:A104	R:R:F159	2.77	No	No	0	5	4
82	R:R:D106	R:R:Y310	9.2	No	Yes	1	7	7
83	L:L:?1	R:R:D106	6.92	Yes	No	1	0	7
84	R:R:S158	R:R:V107	6.46	No	No	0	7	6
85	L:L:?1	R:R:V107	13.94	Yes	No	0	0	6
86	R:R:M108	R:R:S158	4.6	No	No	0	6	7
87	R:R:C110	R:R:W281	5.22	No	Yes	0	6	8
88	L:L:?1	R:R:C110	12.15	Yes	No	0	0	6
89	R:R:S111	R:R:T196	7.99	No	Yes	1	7	6
90	L:L:?1	R:R:S111	2.55	Yes	No	1	0	7
91	R:R:A112	R:R:W151	6.48	No	Yes	0	7	9
92	R:R:I114	R:R:P200	3.39	No	Yes	0	8	9
93	R:R:A150	R:R:L115	3.15	No	No	0	7	5
94	R:R:N116	R:R:W151	3.39	No	Yes	1	8	9
95	R:R:F277	R:R:L117	2.44	Yes	Yes	1	9	9
96	R:R:L117	R:R:N316	6.87	Yes	Yes	1	9	9
97	R:R:L117	R:R:Y320	3.52	Yes	Yes	1	9	9
98	R:R:C118	R:R:P200	3.77	No	Yes	0	7	9
99	R:R:C118	R:R:I204	4.91	No	No	0	7	8
100	R:R:I120	R:R:R124	2.51	Yes	Yes	0	9	9
101	R:R:I204	R:R:S121	6.19	No	No	0	8	9
102	R:R:S121	R:R:T207	7.99	No	No	0	9	7
103	R:R:S121	R:R:Y208	5.09	No	Yes	0	9	9
104	R:R:L122	R:R:L126	2.77	No	No	0	7	4
105	R:R:D123	R:R:Y134	6.9	Yes	Yes	2	9	8
106	R:R:D123	R:R:M138	4.16	Yes	No	2	9	7
107	R:R:R124	R:R:Y320	7.2	Yes	Yes	0	9	9
108	R:R:M324	R:R:R124	3.72	No	Yes	0	8	9
109	R:R:L129	R:R:Y125	10.55	No	No	0	7	8
110	R:R:T207	R:R:Y125	9.99	No	No	0	7	8
111	R:R:R210	R:R:Y125	12.35	No	No	0	5	8
112	R:R:L126	R:R:S130	3	No	No	0	4	6
113	R:R:L127	R:R:Y134	11.72	No	Yes	0	8	8
114	R:R:I128	R:R:L129	2.85	No	No	0	9	7
115	R:R:I128	R:R:I211	4.42	No	No	0	9	9
116	R:R:R137	R:R:S130	2.64	No	No	0	4	6
117	R:R:R133	R:R:R137	11.73	No	No	4	4	4
118	R:R:M138	R:R:Y134	10.78	No	Yes	2	7	8
119	R:R:P140	R:R:T139	3.5	No	No	0	3	8
120	R:R:R142	R:R:T139	3.88	No	No	0	6	8
121	R:R:L144	R:R:L148	5.54	No	No	0	2	3
122	R:R:V147	R:R:W151	2.45	No	Yes	0	8	9
123	R:R:L156	R:R:L160	5.54	No	Yes	0	3	5
124	R:R:F159	R:R:S158	5.28	No	No	0	4	7
125	R:R:L160	R:R:P161	4.93	Yes	No	0	5	5
126	R:R:L160	R:R:L164	4.15	Yes	No	5	5	5
127	R:R:L160	R:R:W166	3.42	Yes	No	5	5	4
128	R:R:H167	R:R:P161	4.58	No	No	0	4	5
129	R:R:F188	R:R:P161	7.22	No	No	0	7	5
130	R:R:L164	R:R:W166	7.97	No	No	5	5	4
131	R:R:H167	R:R:L183	9	No	No	0	4	4
132	R:R:G170	R:R:S185	3.71	No	No	0	2	5
133	R:R:P174	R:R:R173	4.32	No	No	0	2	3
134	R:R:R173	R:R:R181	3.2	No	No	0	3	4
135	R:R:L183	R:R:R173	3.64	No	No	0	4	3
136	R:R:P177	R:R:V176	3.53	No	No	0	1	4
137	R:R:D303	R:R:R181	8.34	No	No	0	3	4
138	R:R:L183	R:R:S185	7.51	No	No	0	4	5
139	R:R:P187	R:R:S185	3.56	No	No	0	4	5
140	R:R:A192	R:R:F188	4.16	No	No	0	6	7
141	R:R:N288	R:R:V189	4.43	No	No	0	6	5
142	L:L:?1	R:R:A192	2.68	Yes	No	0	0	6
143	R:R:G194	R:R:S193	3.71	No	Yes	0	4	6
144	R:R:F285	R:R:S193	2.64	Yes	Yes	1	6	6
145	L:L:?1	R:R:S193	2.55	Yes	Yes	1	0	6
146	R:R:F198	R:R:G194	4.52	No	No	0	5	4
147	R:R:F285	R:R:T196	2.59	Yes	Yes	1	6	6
148	L:L:?1	R:R:T196	5.01	Yes	Yes	1	0	6
149	R:R:F197	R:R:F198	5.36	Yes	No	0	8	5
150	R:R:F197	R:R:F277	3.22	Yes	Yes	1	8	9
151	R:R:F197	R:R:W281	3.01	Yes	Yes	1	8	8
152	R:R:F197	R:R:L282	2.44	Yes	No	0	8	6
153	R:R:F197	R:R:F285	27.86	Yes	Yes	1	8	6
154	R:R:F278	R:R:S201	6.61	No	No	0	5	7
155	R:R:C205	R:R:F278	2.79	No	No	0	5	5
156	R:R:F206	R:R:R210	6.41	No	No	0	5	5
157	R:R:L274	R:R:Y208	10.55	No	Yes	0	8	9
158	R:R:L212	R:R:R216	3.64	No	Yes	0	6	5
159	R:R:L212	R:R:L270	4.15	No	No	0	6	8
160	R:R:A219	R:R:R216	2.77	No	Yes	0	6	5
161	R:R:A263	R:R:R216	4.15	No	Yes	0	7	5
162	R:R:L264	R:R:S267	4.5	No	No	0	4	7
163	R:R:I272	R:R:L268	7.14	No	No	0	7	7
164	R:R:F323	R:R:T269	7.78	No	No	0	7	9
165	R:R:F323	R:R:L273	6.09	No	No	0	7	8
166	R:R:M276	R:R:T280	4.52	Yes	No	1	6	9
167	R:R:M276	R:R:N312	7.01	Yes	Yes	1	6	9
168	R:R:M276	R:R:M315	2.89	Yes	No	1	6	6
169	R:R:M276	R:R:N316	2.8	Yes	Yes	1	6	9
170	R:R:I319	R:R:M276	2.92	No	Yes	1	8	6
171	R:R:F277	R:R:W281	8.02	Yes	Yes	1	9	8
172	R:R:N312	R:R:T280	17.55	Yes	No	1	9	9
173	R:R:F285	R:R:W281	6.01	Yes	Yes	1	6	8
174	R:R:N312	R:R:W281	6.78	Yes	Yes	1	9	8
175	R:R:L282	R:R:V286	2.98	No	No	0	6	5
176	R:R:L305	R:R:P283	3.28	No	No	0	4	9
177	R:R:F284	R:R:F302	4.29	No	No	1	7	4
178	R:R:F284	R:R:T306	7.78	No	No	1	7	4
179	L:L:?1	R:R:F284	6.21	Yes	No	1	0	7
180	L:L:?1	R:R:F285	5.18	Yes	Yes	1	0	6
181	R:R:A287	R:R:F302	2.77	No	No	0	4	4
182	L:L:?1	R:R:N288	7.01	Yes	No	0	0	6
183	R:R:D295	R:R:V290	4.38	No	No	0	1	4
184	R:R:I297	R:R:Q291	5.49	No	No	0	5	3
185	R:R:C296	R:R:D295	3.11	No	No	0	1	1
186	R:R:I297	R:R:L301	2.85	No	No	0	5	4
187	R:R:P299	R:R:S298	3.56	No	No	0	2	5
188	R:R:D303	R:R:G300	3.35	No	No	0	3	1
189	R:R:L301	R:R:L305	2.77	No	No	0	4	4
190	R:R:F302	R:R:T306	2.59	No	No	1	4	4
191	R:R:T306	R:R:Y310	6.24	No	Yes	1	4	7
192	R:R:W307	R:R:Y310	9.65	Yes	Yes	0	5	7
193	R:R:I318	R:R:M315	2.92	No	No	0	7	6
194	R:R:I319	R:R:M315	2.92	No	No	1	8	6
195	R:R:N316	R:R:P317	4.89	Yes	Yes	1	9	9
196	R:R:N316	R:R:Y320	9.3	Yes	Yes	1	9	9
197	R:R:F327	R:R:P321	5.78	Yes	No	0	8	7
198	R:R:F323	R:R:L322	2.44	No	No	0	7	5
199	R:R:F327	R:R:M324	4.98	Yes	No	0	8	8
200	R:R:D326	R:R:R329	8.34	No	No	0	6	4
201	R:R:G332	R:R:P336	4.06	No	No	0	4	5
202	R:R:F334	R:R:R333	8.55	No	No	0	5	3
203	R:R:L335	R:R:P336	4.93	No	No	0	6	5
204	R:R:K135	R:R:Y134	2.39	No	Yes	0	4	8
205	R:R:Q179	R:R:R91	2.34	No	No	0	4	4
206	R:R:L126	R:R:Y134	2.34	No	Yes	0	4	8
207	R:R:L270	R:R:Y208	2.34	No	Yes	0	8	9
208	R:R:M84	R:R:W307	2.33	No	Yes	0	5	5
209	R:R:L169	R:R:W166	2.28	No	No	0	1	4
210	R:R:F105	R:R:F159	2.14	No	No	0	4	4
211	R:R:F277	R:R:F278	2.14	Yes	No	0	9	5
212	R:R:R124	R:R:Y208	2.06	Yes	Yes	0	9	9
213	R:R:R96	R:R:W92	2	No	Yes	0	2	8
214	R:R:C205	R:R:G202	1.96	No	No	0	5	4
215	R:R:A30	R:R:G27	1.95	No	No	0	6	4
216	R:R:P174	R:R:P175	1.95	No	No	0	2	1
217	R:R:C337	R:R:P338	1.88	No	No	0	9	1
218	R:R:G27	R:R:S26	1.86	No	No	0	4	4
219	R:R:G149	R:R:S152	1.86	No	No	0	3	3
220	R:R:G300	R:R:S298	1.86	No	No	0	1	5
221	R:R:G178	R:R:V176	1.84	No	No	0	4	4
222	R:R:A203	R:R:C118	1.81	No	No	0	6	7
223	R:R:A112	R:R:A154	1.79	No	No	0	7	7
224	R:R:P131	R:R:S130	1.78	No	No	0	8	6
225	R:R:P140	R:R:T60	1.75	No	No	0	3	6
226	R:R:G97	R:R:L100	1.71	No	No	0	3	4
227	R:R:G149	R:R:L148	1.71	No	No	0	3	3
228	R:R:G275	R:R:L274	1.71	No	No	0	5	8
229	R:R:G332	R:R:L331	1.71	No	No	0	4	7
230	R:R:G90	R:R:N86	1.7	No	No	0	4	3
231	R:R:A292	R:R:V189	1.7	No	No	0	4	5
232	R:R:G309	R:R:N312	1.7	No	Yes	0	6	9
233	R:R:C99	R:R:T103	1.69	No	No	0	9	4
234	R:R:C52	R:R:I48	1.64	No	No	0	4	8
235	R:R:L115	R:R:P200	1.64	No	Yes	0	5	9
236	R:R:G178	R:R:Q179	1.64	No	No	0	4	4
237	R:R:L186	R:R:P187	1.64	No	No	0	3	4
238	R:R:L199	R:R:P200	1.64	No	Yes	0	5	9
239	R:R:L282	R:R:P283	1.64	No	No	0	6	9
240	R:R:C34	R:R:M84	1.62	No	No	0	3	5
241	R:R:A43	R:R:I318	1.62	No	No	0	9	7
242	R:R:V35	R:R:V36	1.6	No	No	0	5	7
243	R:R:T40	R:R:V36	1.59	No	No	1	7	7
244	R:R:T314	R:R:V36	1.59	No	No	1	6	7
245	R:R:T70	R:R:V66	1.59	No	No	0	6	7
246	R:R:P55	R:R:Q54	1.58	No	Yes	0	6	6
247	R:R:A95	R:R:L98	1.58	No	No	0	7	4
248	R:R:A104	R:R:L162	1.58	No	No	0	5	5
249	R:R:I289	R:R:S193	1.55	No	Yes	0	6	6
250	R:R:A214	R:R:Q218	1.52	No	No	0	6	7
251	R:R:L68	R:R:S113	1.5	Yes	No	0	9	9
252	R:R:L94	R:R:V93	1.49	No	No	0	5	3
253	R:R:L190	R:R:V189	1.49	No	No	0	5	5
254	R:R:L305	R:R:V304	1.49	No	No	0	4	4
255	R:R:L141	R:R:T139	1.47	No	No	0	4	8
256	R:R:L195	R:R:T196	1.47	No	Yes	0	3	6
257	R:R:L270	R:R:T269	1.47	No	No	0	8	9
258	R:R:D295	R:R:V293	1.46	No	No	0	1	5
259	R:R:Q291	R:R:V290	1.43	No	No	0	3	4
260	R:R:L115	R:R:L153	1.38	No	No	0	5	4
261	R:R:L119	R:R:L146	1.38	No	No	0	7	6
262	R:R:A266	R:R:R216	1.38	No	Yes	0	8	5
263	R:R:D326	R:R:L57	1.36	No	Yes	0	6	9
264	R:R:K328	R:R:R325	1.24	No	No	0	9	5
265	R:R:L136	R:R:R133	1.21	No	No	4	4	4
266	R:R:L136	R:R:R137	1.21	No	No	4	4	4
267	R:R:L213	R:R:R210	1.21	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N44	5.7975	4	1	9
2	R:R:Q54	5.29667	6	0	6
3	R:R:L57	4.5175	4	3	9
4	R:R:F64	4.956	5	0	8
5	R:R:L65	3.2125	4	0	8
6	R:R:L68	4.16667	6	1	9
7	R:R:F69	5.0025	4	0	9
8	R:R:D72	5.1725	4	1	9
9	R:R:L73	5.265	4	0	7
10	R:R:V79	4.8	4	1	7
11	R:R:M80	5.51	4	0	7
12	R:R:W92	6.3925	4	0	8
13	R:R:L117	4.245	4	1	9
14	R:R:I120	3.3525	4	0	9
15	R:R:D123	7.2925	4	2	9
16	R:R:R124	3.8725	4	0	9
17	R:R:Y134	5.77857	7	2	8
18	R:R:W151	4.194	5	1	9
19	R:R:L160	4.51	4	5	5
20	R:R:S193	2.6125	4	1	6
21	R:R:T196	4.265	4	1	6
22	R:R:F197	8.378	5	1	8
23	R:R:P200	2.61	4	0	9
24	R:R:Y208	5.01	4	0	9
25	R:R:R216	2.985	4	0	5
26	R:R:M276	4.028	5	1	6
27	R:R:F277	3.955	4	1	9
28	R:R:W281	5.808	5	1	8
29	R:R:F285	8.856	5	1	6
30	R:R:W307	5.026	5	0	5
31	R:R:Y310	6.494	5	1	7
32	R:R:N312	8.26	4	1	9
33	R:R:N316	5.596	5	1	9
34	R:R:P317	5.5875	4	1	9
35	R:R:Y320	5.885	4	1	9
36	R:R:F327	5.342	5	3	8
37	L:L:?1	6.42	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M80	R:R:Y310	17.0377	3.59	Yes	Yes	0	7	7
2	R:R:W307	R:R:Y310	14.1326	9.65	Yes	Yes	0	5	7
3	R:R:N44	R:R:T40	19.2363	4.39	Yes	No	1	9	7
4	R:R:T314	R:R:T40	17.5512	14.13	No	No	1	6	7
5	R:R:M80	R:R:T314	18.1129	3.01	Yes	No	0	7	6
6	R:R:D72	R:R:N44	12.1407	4.04	Yes	Yes	1	9	9
7	R:R:F69	R:R:P317	11.0793	2.89	Yes	Yes	0	9	9
8	R:R:L57	R:R:Q54	20.3908	6.65	Yes	Yes	0	9	6
9	R:R:F327	R:R:L57	25.7116	7.31	Yes	Yes	3	8	9
10	R:R:D72	R:R:L68	13.7225	2.71	Yes	Yes	1	9	9
11	R:R:I120	R:R:L68	36.0431	4.28	Yes	Yes	0	9	9
12	R:R:F64	R:R:I120	38.5037	3.77	Yes	Yes	0	8	9
13	R:R:D123	R:R:F64	25.112	10.75	Yes	Yes	0	9	8
14	R:R:D123	R:R:Y134	20.9801	6.9	Yes	Yes	2	9	8
15	R:R:F63	R:R:V147	12.4681	5.24	No	No	0	4	8
16	R:R:F64	R:R:V147	10.0041	2.62	Yes	No	0	8	8
17	R:R:N116	R:R:W151	11.9546	3.39	No	Yes	1	8	9
18	R:R:L68	R:R:N116	14.6702	8.24	Yes	No	1	9	8
19	R:R:N316	R:R:P317	11.6342	4.89	Yes	Yes	1	9	9
20	R:R:D106	R:R:Y310	10.9139	9.2	No	Yes	1	7	7
21	L:L:?1	R:R:D106	42.3048	6.92	Yes	No	1	0	7
22	L:L:?1	R:R:C110	33.1243	12.15	Yes	No	0	0	6
23	R:R:C110	R:R:W281	33.4516	5.22	No	Yes	0	6	8
24	R:R:F277	R:R:W281	62.313	8.02	Yes	Yes	1	9	8
25	R:R:F277	R:R:L117	100	2.44	Yes	Yes	1	9	9
26	R:R:L117	R:R:Y320	56.782	3.52	Yes	Yes	1	9	9
27	L:L:?1	R:R:F285	66.4312	5.18	Yes	Yes	1	0	6
28	R:R:F285	R:R:W281	36.3188	6.01	Yes	Yes	1	6	8
29	R:R:F197	R:R:F285	36.6462	27.86	Yes	Yes	1	8	6
30	R:R:F197	R:R:F277	40.0613	3.22	Yes	Yes	1	8	9
31	R:R:L65	R:R:M324	14.6599	2.83	Yes	No	0	8	8
32	R:R:V79	R:R:W102	31.6183	4.9	Yes	No	0	7	5
33	R:R:C99	R:R:W92	23.4131	6.53	No	Yes	0	9	8
34	R:R:C99	R:R:T103	26.4181	1.69	No	No	0	9	4
35	R:R:T103	R:R:W102	29.3714	4.85	No	No	0	4	5
36	R:R:F159	R:R:S158	13.3193	5.28	No	No	0	4	7
37	R:R:S158	R:R:V107	17.0894	6.46	No	No	0	7	6
38	L:L:?1	R:R:V107	18.9641	13.94	Yes	No	0	0	6
39	R:R:C118	R:R:I204	12.1821	4.91	No	No	0	7	8
40	R:R:I204	R:R:S121	13.6743	6.19	No	No	0	8	9
41	R:R:S121	R:R:Y208	26.7937	5.09	No	Yes	0	9	9
42	R:R:R124	R:R:Y208	44.5034	2.06	Yes	Yes	0	9	9
43	R:R:I120	R:R:R124	10.8209	2.51	Yes	Yes	0	9	9
44	R:R:R124	R:R:Y320	46.3747	7.2	Yes	Yes	0	9	9
45	R:R:S121	R:R:T207	12.1821	7.99	No	No	0	9	7
46	R:R:L126	R:R:Y134	10.0317	2.34	No	Yes	0	4	8
47	R:R:T207	R:R:Y125	10.683	9.99	No	No	0	7	8
48	R:R:F188	R:R:P161	37.2458	7.22	No	No	0	7	5
49	R:R:A192	R:R:F188	39.0447	4.16	No	No	0	6	7
50	L:L:?1	R:R:A192	40.8367	2.68	Yes	No	0	0	6
51	R:R:H167	R:R:P161	26.3078	4.58	No	No	0	4	5
52	R:R:H167	R:R:L183	24.4607	9	No	No	0	4	4
53	R:R:L183	R:R:R173	15.1216	3.64	No	No	0	4	3
54	R:R:F197	R:R:L282	10.8726	2.44	Yes	No	0	8	6
55	R:R:L270	R:R:Y208	15.0183	2.34	No	Yes	0	8	9
56	R:R:L117	R:R:L68	37.3699	4.15	Yes	Yes	1	9	9
57	R:R:D106	R:R:V79	30.1916	7.3	No	Yes	1	7	7
58	R:R:M324	R:R:R124	16.9102	3.72	No	Yes	0	8	9
59	R:R:L65	R:R:Y320	15.8316	3.52	Yes	Yes	0	8	9
60	R:R:F327	R:R:M324	28.7132	4.98	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D106	R:R:V79	7.3	1	No	Yes	7	7	1	2
R:R:V79	R:R:Y310	3.79	1	Yes	Yes	7	7	2	2
R:R:D106	R:R:Y310	9.2	1	No	Yes	7	7	1	2
L:L:?1	R:R:D106	6.92	1	Yes	No	0	7	0	1
R:R:S158	R:R:V107	6.46	0	No	No	7	6	2	1
L:L:?1	R:R:V107	13.94	1	Yes	No	0	6	0	1
R:R:C110	R:R:W281	5.22	0	No	Yes	6	8	1	2
L:L:?1	R:R:C110	12.15	1	Yes	No	0	6	0	1
R:R:S111	R:R:T196	7.99	1	No	Yes	7	6	1	1
L:L:?1	R:R:S111	2.55	1	Yes	No	0	7	0	1
R:R:A192	R:R:F188	4.16	0	No	No	6	7	1	2
R:R:N288	R:R:V189	4.43	0	No	No	6	5	1	2
L:L:?1	R:R:A192	2.68	1	Yes	No	0	6	0	1
R:R:G194	R:R:S193	3.71	0	No	Yes	4	6	2	1
R:R:F285	R:R:S193	2.64	1	Yes	Yes	6	6	1	1
L:L:?1	R:R:S193	2.55	1	Yes	Yes	0	6	0	1
R:R:F285	R:R:T196	2.59	1	Yes	Yes	6	6	1	1
L:L:?1	R:R:T196	5.01	1	Yes	Yes	0	6	0	1
R:R:F197	R:R:W281	3.01	1	Yes	Yes	8	8	2	2
R:R:F197	R:R:F285	27.86	1	Yes	Yes	8	6	2	1
R:R:F285	R:R:W281	6.01	1	Yes	Yes	6	8	1	2
R:R:F284	R:R:F302	4.29	1	No	No	7	4	1	2
R:R:F284	R:R:T306	7.78	1	No	No	7	4	1	2
L:L:?1	R:R:F284	6.21	1	Yes	No	0	7	0	1
L:L:?1	R:R:F285	5.18	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N288	7.01	1	Yes	No	0	6	0	1
R:R:F302	R:R:T306	2.59	1	No	No	4	4	2	2
R:R:T306	R:R:Y310	6.24	1	No	Yes	4	7	2	2
R:R:I289	R:R:S193	1.55	0	No	Yes	6	6	2	1
R:R:L195	R:R:T196	1.47	0	No	Yes	3	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XTB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	240
Number of Links	267
Number of Hubs	37
Number of Links mediated by Hubs	130
Number of Communities	5
Number of Nodes involved in Communities	45
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	52968
Length Of Smallest Path	3
Average Path Length	13.1682
Length of Longest Path	27
Minimum Path Strength	1.51
Average Path Strength	5.40346
Maximum Path Strength	16.61
Minimum Path Correlation	0.7
Average Path Correlation	0.932174
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	49.6695
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.6181
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • histamine receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of TOR signaling • positive regulation of cellular process • TOR signaling • regulation of signaling • regulation of TOR signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • cerebral cortex cell migration • head development • forebrain development • brain development • nervous system development • pallium development • cerebral cortex development • telencephalon cell migration • central nervous system development • forebrain cell migration • cell migration • telencephalon development • cell motility • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	Serotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P50406
Sequence	>7XTB_nogp_Chain_R S G W V A A A L C V V I A L T A A A N S L L I A L I C T Q P A L R N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G R W V L A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S P L R Y K L R M T P L R A L A L V L G A W S L A A L A S F L P L L L G W H E L G H A R P P V P G Q C R L L A S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T T A L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C D C I S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D F K R A L G R F L P C P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JLZ	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	ST1936	-	Gs/β1/γ2	3.09	2023-06-28	10.1016/j.bbrc.2023.05.126
	8JLZ (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	ST1936	-		3.09	2023-06-28	10.1016/j.bbrc.2023.05.126
	7YS6	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-	chim(NtGi1-Gs)/β1/γ2	3	2023-03-29	10.1073/pnas.2209917120
	7YS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-		3	2023-03-29	10.1073/pnas.2209917120
	7XTB	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.3	2022-07-27	10.1016/j.molcel.2022.05.031
	7XTB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₆	Homo sapiens	Serotonin	-		3.3	2022-07-27	10.1016/j.molcel.2022.05.031

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