psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A1	R:R:E121	3.02	No	No	0	0	5
2	L:L:A1	R:R:Y125	8.01	No	Yes	0	0	6
3	L:L:S2	L:L:T5	3.2	No	No	0	0	0
4	L:L:S2	R:R:R183	3.95	No	Yes	0	0	6
5	L:L:V3	R:R:Y125	2.52	No	Yes	9	0	6
6	L:L:V3	R:R:S300	3.23	No	No	9	0	7
7	L:L:A4	R:R:A297	1.79	No	No	0	0	5
8	L:L:T5	R:R:Y197	2.5	No	Yes	0	0	4
9	L:L:E6	L:L:R8	5.82	Yes	Yes	2	0	0
10	L:L:E6	R:R:R208	5.82	Yes	Yes	2	0	4
11	L:L:E6	R:R:R278	3.49	Yes	Yes	2	0	4
12	L:L:E6	R:R:N293	2.63	Yes	Yes	2	0	4
13	L:L:E6	R:R:L296	6.63	Yes	No	0	0	4
14	L:L:H34	L:L:L7	2.57	No	No	0	0	0
15	L:L:L7	R:R:Y197	5.86	No	Yes	0	0	4
16	L:L:R8	R:R:D274	4.76	Yes	Yes	0	0	5
17	L:L:R8	R:R:R289	13.86	Yes	Yes	2	0	3
18	L:L:R8	R:R:N293	10.85	Yes	Yes	2	0	4
19	L:L:C35	L:L:C9	7.28	No	No	10	0	0
20	L:L:C9	L:L:E39	3.04	No	No	10	0	0
21	L:L:K29	L:L:Q10	6.78	No	Yes	0	0	0
22	L:L:I41	L:L:Q10	2.74	No	Yes	5	0	0
23	L:L:Q10	R:R:V38	4.3	Yes	Yes	5	0	4
24	L:L:Q10	R:R:V190	2.87	Yes	No	0	0	1
25	L:L:C11	L:L:E39	6.08	No	No	0	0	0
26	L:L:C11	L:L:C51	7.28	No	No	0	0	0
27	L:L:L12	R:R:D284	6.79	No	No	2	0	1
28	L:L:L12	R:R:R289	4.86	No	Yes	2	0	3
29	L:L:L15	L:L:Q13	7.99	No	No	0	0	0
30	L:L:Q13	R:R:S37	10.11	No	No	0	0	4
31	L:L:N53	L:L:T14	4.39	No	No	0	0	0
32	L:L:P54	L:L:T14	6.99	No	No	0	0	0
33	L:L:L15	R:R:F32	3.65	No	Yes	0	0	3
34	L:L:N53	L:L:Q16	10.56	No	No	0	0	0
35	L:L:G17	R:R:S29	1.86	No	No	0	0	6
36	L:L:I18	L:L:L52	2.85	No	No	0	0	0
37	L:L:H19	L:L:N22	8.93	Yes	No	0	0	0
38	L:L:H19	L:L:I23	2.65	Yes	No	0	0	0
39	L:L:H19	L:L:L44	3.86	Yes	Yes	6	0	0
40	L:L:H19	R:R:Y28	13.07	Yes	No	6	0	7
41	L:L:H19	R:R:F32	6.79	Yes	Yes	6	0	3
42	L:L:P20	R:R:G25	2.03	No	No	0	0	2
43	L:L:K21	R:R:D13	11.06	No	No	3	0	6
44	L:L:K21	R:R:W17	3.48	No	Yes	3	0	5
45	L:L:I23	R:R:L11	4.28	No	Yes	0	0	6
46	L:L:Q24	L:L:T43	4.25	No	No	0	0	0
47	L:L:K45	L:L:Q24	4.07	No	No	0	0	0
48	L:L:S25	L:L:T43	6.4	No	No	0	0	0
49	L:L:A42	L:L:V26	3.39	No	No	0	0	0
50	L:L:N27	R:R:F6	2.42	No	No	0	0	6
51	L:L:N27	R:R:T8	10.24	No	No	0	0	6
52	L:L:V28	L:L:V40	3.21	No	No	0	0	0
53	L:L:V28	R:R:T8	6.35	No	No	0	0	6
54	L:L:P31	L:L:S30	1.78	No	No	0	0	0
55	L:L:S30	R:R:F6	2.64	No	No	0	0	6
56	L:L:P31	L:L:T38	10.49	No	No	0	0	0
57	L:L:G32	L:L:P33	4.06	No	Yes	0	0	0
58	L:L:G32	L:L:H34	4.77	No	No	0	0	0
59	L:L:P33	R:R:V186	3.53	Yes	No	0	0	1
60	L:L:P33	R:R:N199	4.89	Yes	No	0	0	4
61	L:L:P33	R:R:T204	1.75	Yes	No	0	0	3
62	L:L:H34	R:R:P189	18.3	No	No	0	0	2
63	L:L:C35	L:L:E39	3.04	No	No	10	0	0
64	L:L:A36	L:L:Q37	3.03	No	No	0	0	0
65	L:L:L52	L:L:V40	4.47	No	No	0	0	0
66	L:L:I41	L:L:K49	5.82	No	Yes	5	0	0
67	L:L:I41	R:R:V38	6.14	No	Yes	5	0	4
68	L:L:K49	L:L:T43	6.01	Yes	No	0	0	0
69	L:L:L44	R:R:F32	2.44	Yes	Yes	6	0	3
70	L:L:G47	L:L:N46	5.09	No	No	0	0	0
71	L:L:K49	R:R:V38	3.04	Yes	Yes	5	0	4
72	L:L:K49	R:R:E40	6.75	Yes	No	0	0	4
73	L:L:L52	L:L:V59	4.47	No	No	0	0	0
74	L:L:I58	L:L:N53	4.25	No	No	0	0	0
75	L:L:A55	L:L:P57	1.87	No	No	0	0	0
76	L:L:P57	L:L:S56	1.78	No	No	0	0	0
77	L:L:K60	L:L:S56	6.12	No	No	0	0	0
78	L:L:I58	L:L:V59	3.07	No	No	0	0	0
79	L:L:I63	L:L:K60	11.63	No	No	0	0	0
80	L:L:I62	L:L:K61	8.72	No	No	3	0	0
81	L:L:K61	R:R:Y26	5.97	No	No	3	0	3
82	L:L:I62	R:R:L21	4.28	No	Yes	3	0	5
83	L:L:I62	R:R:Y26	6.04	No	No	3	0	3
84	R:R:F6	R:R:K192	3.72	No	No	0	6	5
85	R:R:I9	R:R:N18	9.91	No	No	0	6	9
86	R:R:D12	R:R:F10	9.55	No	No	0	6	6
87	R:R:D13	R:R:L11	6.79	No	Yes	3	6	6
88	R:R:L11	R:R:W17	2.28	Yes	Yes	3	6	5
89	R:R:E19	R:R:L11	6.63	Yes	Yes	3	8	6
90	R:R:D12	R:R:D14	14.64	No	No	0	6	6
91	R:R:D13	R:R:W17	8.93	No	Yes	3	6	5
92	R:R:E19	R:R:W17	3.27	Yes	Yes	3	8	5
93	R:R:L21	R:R:W17	6.83	Yes	Yes	3	5	5
94	R:R:N22	R:R:W17	11.3	No	Yes	0	5	5
95	R:R:E19	R:R:L21	7.95	Yes	Yes	3	8	5
96	R:R:L21	R:R:S24	6.01	Yes	No	0	5	8
97	R:R:M23	R:R:N22	7.01	No	No	0	3	5
98	R:R:S24	R:R:Y26	11.45	No	No	0	8	3
99	R:R:S29	R:R:Y28	2.54	No	No	0	6	7
100	R:R:F32	R:R:Y28	5.16	Yes	No	6	3	7
101	R:R:G30	R:R:S29	1.86	No	No	0	4	6
102	R:R:C286	R:R:C39	3.64	No	No	0	8	8
103	R:R:C39	R:R:R289	8.36	No	Yes	0	8	3
104	R:R:G290	R:R:T42	1.82	No	No	0	3	3
105	R:R:G290	R:R:T43	1.82	No	No	0	3	4
106	R:R:N293	R:R:V44	4.43	Yes	No	0	4	4
107	R:R:P46	R:R:V45	3.53	No	Yes	11	2	4
108	R:R:V45	R:R:W49	2.45	Yes	No	11	4	5
109	R:R:N50	R:R:V45	4.43	No	Yes	0	4	4
110	R:R:A297	R:R:V45	3.39	No	Yes	0	5	4
111	R:R:P46	R:R:W49	28.38	No	No	11	2	5
112	R:R:V51	R:R:Y47	3.79	No	No	12	5	4
113	R:R:E103	R:R:Y47	5.61	No	No	12	6	4
114	R:R:F107	R:R:Y47	7.22	No	No	0	5	4
115	R:R:T48	R:R:W49	4.85	No	No	0	1	5
116	R:R:E103	R:R:V51	4.28	No	No	12	6	5
117	R:R:G52	R:R:S55	1.86	No	No	0	5	6
118	R:R:I53	R:R:I57	2.94	No	No	0	5	7
119	R:R:I53	R:R:L301	7.14	No	No	0	5	5
120	R:R:I57	R:R:L54	4.28	No	No	0	7	7
121	R:R:L100	R:R:L54	4.15	No	No	0	8	7
122	R:R:I57	R:R:L305	2.85	No	No	0	7	4
123	R:R:F58	R:R:L59	2.44	Yes	No	0	7	4
124	R:R:F58	R:R:S93	5.28	Yes	No	0	7	9
125	R:R:F58	R:R:L96	7.31	Yes	No	0	7	8
126	R:R:F58	R:R:S97	6.61	Yes	No	0	7	6
127	R:R:F58	R:R:L100	3.65	Yes	No	0	7	8
128	R:R:N61	R:R:N65	9.54	Yes	No	0	9	9
129	R:R:N61	R:R:S93	4.47	Yes	No	0	9	9
130	R:R:L96	R:R:N61	2.75	No	Yes	0	8	9
131	R:R:A308	R:R:N61	3.13	No	Yes	0	7	9
132	R:R:S93	R:R:V62	6.46	No	No	0	9	5
133	R:R:C90	R:R:N65	11.02	No	No	1	8	9
134	R:R:N65	R:R:P311	3.26	No	Yes	1	9	9
135	R:R:G66	R:R:T69	1.82	No	No	0	3	6
136	R:R:C90	R:R:V68	3.42	No	No	1	8	9
137	R:R:P311	R:R:V68	1.77	Yes	No	1	9	9
138	R:R:F321	R:R:V68	2.62	Yes	No	0	8	9
139	R:R:L87	R:R:T69	2.95	No	No	0	6	6
140	R:R:K74	R:R:Y70	14.33	No	No	0	4	4
141	R:R:L328	R:R:Y70	7.03	No	No	0	6	4
142	R:R:F321	R:R:I71	8.79	Yes	No	0	8	6
143	R:R:I71	R:R:R324	6.26	No	No	0	6	5
144	R:R:D83	R:R:F72	3.58	No	No	0	7	6
145	R:R:F72	R:R:I84	2.51	No	Yes	0	6	6
146	R:R:F72	R:R:L87	10.96	No	No	0	6	6
147	R:R:H75	R:R:K74	3.93	No	No	0	4	4
148	R:R:H75	R:R:R324	22.57	No	No	0	4	5
149	R:R:R78	R:R:S77	2.64	No	No	0	4	5
150	R:R:A81	R:R:G161	1.95	No	No	0	7	7
151	R:R:I82	R:R:V142	6.14	No	No	0	8	9
152	R:R:I82	R:R:R143	2.51	No	Yes	0	8	9
153	R:R:I84	R:R:Q158	6.86	Yes	No	13	6	3
154	R:R:G161	R:R:I84	3.53	No	Yes	0	7	6
155	R:R:I84	R:R:W162	12.92	Yes	No	13	6	3
156	R:R:C138	R:R:L85	3.17	No	No	0	6	6
157	R:R:L85	R:R:V139	4.47	No	No	0	6	8
158	R:R:L86	R:R:Y314	4.69	No	Yes	0	7	9
159	R:R:G88	R:R:T165	1.82	No	No	0	9	6
160	R:R:I89	R:R:S135	4.64	No	No	0	9	7
161	R:R:I89	R:R:V310	3.07	No	Yes	1	9	9
162	R:R:I89	R:R:P311	5.08	No	Yes	1	9	9
163	R:R:C90	R:R:P311	3.77	No	Yes	1	8	9
164	R:R:N92	R:R:Y128	8.14	No	No	0	8	9
165	R:R:L131	R:R:N92	5.49	No	No	0	7	8
166	R:R:C95	R:R:F124	2.79	No	No	0	6	4
167	R:R:C95	R:R:L127	3.17	No	Yes	0	6	5
168	R:R:L96	R:R:Y128	10.55	No	No	0	8	9
169	R:R:F124	R:R:I98	20.09	No	No	0	4	4
170	R:R:S99	R:R:Y125	2.54	No	Yes	0	7	6
171	R:R:L101	R:R:L105	5.54	No	No	0	9	4
172	R:R:A102	R:R:L117	4.73	No	Yes	0	7	5
173	R:R:E103	R:R:E121	8.88	No	No	0	6	5
174	R:R:L108	R:R:V104	2.98	No	No	0	4	7
175	R:R:I112	R:R:M106	2.92	No	Yes	4	3	6
176	R:R:I113	R:R:M106	5.83	No	Yes	4	8	6
177	R:R:L117	R:R:M106	4.24	Yes	Yes	4	5	6
178	R:R:C196	R:R:M106	3.24	No	Yes	4	9	6
179	R:R:F109	R:R:L108	2.44	No	No	0	4	4
180	R:R:F109	R:R:I112	2.51	No	No	0	4	3
181	R:R:I112	R:R:L117	2.85	No	Yes	4	3	5
182	R:R:I113	R:R:R185	5.01	No	No	4	8	5
183	R:R:A194	R:R:I113	4.87	No	No	4	4	8
184	R:R:G116	R:R:S114	1.86	No	No	0	2	7
185	R:R:C118	R:R:R183	2.79	No	Yes	4	9	6
186	R:R:C118	R:R:C196	7.28	No	No	4	9	9
187	R:R:F124	R:R:L120	4.87	No	No	0	4	4
188	R:R:I122	R:R:Y126	3.63	No	Yes	0	6	5
189	R:R:I122	R:R:R183	13.78	No	Yes	0	6	6
190	R:R:F123	R:R:L173	2.44	Yes	No	0	5	3
191	R:R:F123	R:R:S176	3.96	Yes	Yes	7	5	7
192	R:R:F123	R:R:G177	3.01	Yes	No	7	5	3
193	R:R:C180	R:R:F123	8.38	No	Yes	7	4	5
194	R:R:Y125	R:R:Y126	1.99	Yes	Yes	0	6	5
195	R:R:V129	R:R:Y125	5.05	No	Yes	0	7	6
196	R:R:S300	R:R:Y125	2.54	No	Yes	9	7	6
197	R:R:S176	R:R:Y126	2.54	Yes	Yes	0	7	5
198	R:R:A179	R:R:Y126	2.67	No	Yes	0	5	5
199	R:R:L127	R:R:L173	5.54	Yes	No	0	5	3
200	R:R:L127	R:R:S176	4.5	Yes	Yes	0	5	7
201	R:R:S307	R:R:Y128	8.9	No	No	0	8	9
202	R:R:V129	R:R:Y130	5.05	No	No	0	7	8
203	R:R:Q303	R:R:V129	2.87	No	No	0	8	7
204	R:R:L175	R:R:Y130	9.38	No	No	0	5	8
205	R:R:S215	R:R:Y130	5.09	No	No	0	6	8
206	R:R:D132	R:R:I133	2.8	No	No	0	9	8
207	R:R:D132	R:R:S307	8.83	No	No	0	9	8
208	R:R:I133	R:R:P223	3.39	No	Yes	0	8	9
209	R:R:F260	R:R:I133	2.51	Yes	No	0	9	8
210	R:R:F134	R:R:I171	7.54	No	No	0	6	4
211	R:R:F134	R:R:L175	2.44	No	No	0	6	5
212	R:R:A168	R:R:S135	3.42	No	No	0	6	7
213	R:R:L227	R:R:V136	2.98	No	No	0	8	8
214	R:R:V136	R:R:Y314	8.83	No	Yes	0	8	9
215	R:R:P223	R:R:V137	1.77	Yes	No	0	9	7
216	R:R:L226	R:R:V137	4.47	No	No	0	6	7
217	R:R:C138	R:R:L164	6.35	No	No	0	6	5
218	R:R:R143	R:R:V139	7.85	Yes	No	0	9	8
219	R:R:L227	R:R:S140	3	No	No	14	8	9
220	R:R:F230	R:R:S140	5.28	Yes	No	0	8	9
221	R:R:S140	R:R:Y231	3.82	No	Yes	14	9	9
222	R:R:L141	R:R:L145	4.15	No	No	0	5	6
223	R:R:F230	R:R:L141	7.31	Yes	No	0	8	5
224	R:R:R143	R:R:Y231	8.23	Yes	Yes	0	9	9
225	R:R:R143	R:R:Y314	3.09	Yes	Yes	0	9	9
226	R:R:L145	R:R:Y144	2.34	No	Yes	0	6	8
227	R:R:A148	R:R:Y144	5.34	No	Yes	0	7	8
228	R:R:L233	R:R:Y144	8.21	No	Yes	0	4	8
229	R:R:T234	R:R:Y144	3.75	No	Yes	0	8	8
230	R:R:L145	R:R:Y149	2.34	No	No	0	6	6
231	R:R:L146	R:R:P155	3.28	No	No	0	7	3
232	R:R:K156	R:R:L146	2.82	No	No	0	7	7
233	R:R:T234	R:R:V147	4.76	No	No	0	8	8
234	R:R:V147	R:R:V237	3.21	No	No	0	8	6
235	R:R:A148	R:R:Y149	4	No	No	0	7	6
236	R:R:R152	R:R:W154	4	No	No	0	4	5
237	R:R:P155	R:R:W154	17.57	No	No	0	3	5
238	R:R:Q158	R:R:W162	2.19	No	No	13	3	3
239	R:R:G177	R:R:S176	1.86	No	Yes	7	3	7
240	R:R:C180	R:R:G177	1.96	No	No	7	4	3
241	R:R:D178	R:R:W207	2.23	No	Yes	8	8	4
242	R:R:D178	R:R:H210	6.3	No	No	8	8	3
243	R:R:D178	R:R:V214	2.92	No	No	8	8	4
244	R:R:R181	R:R:W207	13.99	No	Yes	0	4	4
245	R:R:A200	R:R:H182	2.93	No	No	0	5	5
246	R:R:H182	R:R:W207	19.04	No	Yes	0	5	4
247	R:R:C196	R:R:R183	5.57	No	Yes	4	9	6
248	R:R:E198	R:R:R183	13.96	No	Yes	0	5	6
249	R:R:N199	R:R:S184	5.96	No	No	0	4	4
250	R:R:R185	R:R:V187	3.92	No	No	0	5	2
251	R:R:A194	R:R:R185	2.77	No	No	4	4	5
252	R:R:V186	R:R:Y197	2.52	No	Yes	0	1	4
253	R:R:D188	R:R:P189	8.05	Yes	No	0	1	2
254	R:R:D188	R:R:V190	5.84	Yes	No	0	1	1
255	R:R:D188	R:R:S191	8.83	Yes	No	0	1	3
256	R:R:D188	R:R:M195	4.16	Yes	No	0	1	3
257	R:R:Q193	R:R:S191	8.66	No	No	0	2	3
258	R:R:E198	R:R:Y197	2.24	No	Yes	0	5	4
259	R:R:R208	R:R:Y197	8.23	Yes	Yes	2	4	4
260	R:R:R278	R:R:Y197	3.09	Yes	Yes	2	4	4
261	R:R:A200	R:R:T204	3.36	No	No	0	5	3
262	R:R:H210	R:R:W207	14.81	No	Yes	8	3	4
263	R:R:V211	R:R:W207	6.13	No	Yes	0	5	4
264	R:R:R208	R:R:R212	3.2	Yes	Yes	0	4	5
265	R:R:R208	R:R:R278	3.2	Yes	Yes	2	4	4
266	R:R:L209	R:R:T275	5.9	No	No	0	2	5
267	R:R:L209	R:R:R279	2.43	No	No	0	2	3
268	R:R:H210	R:R:V214	2.77	No	No	8	3	4
269	R:R:N271	R:R:R212	13.26	No	Yes	0	5	5
270	R:R:D274	R:R:R212	5.96	Yes	Yes	0	5	5
271	R:R:R212	R:R:T275	3.88	Yes	No	0	5	5
272	R:R:T213	R:R:T217	3.14	No	No	0	4	4
273	R:R:H268	R:R:V216	5.54	No	No	0	9	5
274	R:R:G219	R:R:P223	4.06	No	Yes	0	7	9
275	R:R:F220	R:R:L221	3.65	Yes	No	0	9	4
276	R:R:F220	R:R:L224	3.65	Yes	No	1	9	6
277	R:R:F220	R:R:F260	3.22	Yes	Yes	1	9	9
278	R:R:F220	R:R:F261	4.29	Yes	No	1	9	5
279	R:R:C264	R:R:F220	2.79	No	Yes	1	9	9
280	R:R:F220	R:R:F265	6.43	Yes	No	1	9	5
281	R:R:F220	R:R:H268	10.18	Yes	No	0	9	9
282	R:R:F260	R:R:L224	3.65	Yes	No	1	9	6
283	R:R:F261	R:R:L224	2.44	No	No	1	5	6
284	R:R:F230	R:R:L226	2.44	Yes	No	0	8	6
285	R:R:L227	R:R:Y231	2.34	No	Yes	14	8	9
286	R:R:F230	R:R:L229	3.65	Yes	No	0	8	4
287	R:R:L229	R:R:L233	2.77	No	No	0	4	4
288	R:R:I253	R:R:Y231	15.71	No	Yes	0	7	9
289	R:R:V257	R:R:Y231	2.52	No	Yes	0	7	9
290	R:R:V238	R:R:W235	3.68	No	Yes	0	8	5
291	R:R:R239	R:R:W235	10	No	Yes	0	4	5
292	R:R:V249	R:R:W235	2.45	No	Yes	0	6	5
293	R:R:R250	R:R:W235	7	No	Yes	0	6	5
294	R:R:L243	R:R:T241	7.37	No	No	0	3	6
295	R:R:R246	R:R:T241	2.59	No	No	0	7	6
296	R:R:A245	R:R:K248	3.21	No	No	0	5	7
297	R:R:V256	R:R:Y314	8.83	No	Yes	0	7	9
298	R:R:F263	R:R:L259	4.87	Yes	No	0	8	6
299	R:R:C264	R:R:F260	2.79	No	Yes	1	9	9
300	R:R:F260	R:R:Y306	6.19	Yes	Yes	1	9	9
301	R:R:F261	R:R:F265	10.72	No	No	1	5	5
302	R:R:F263	R:R:L302	2.44	Yes	No	0	8	6
303	R:R:F263	R:R:Y306	9.28	Yes	Yes	0	8	9
304	R:R:C264	R:R:Y306	4.03	No	Yes	1	9	9
305	R:R:F265	R:R:P266	2.89	No	No	0	5	9
306	R:R:P266	R:R:T299	1.75	No	No	0	9	8
307	R:R:N271	R:R:Y267	9.3	No	Yes	0	5	7
308	R:R:T299	R:R:Y267	4.99	No	Yes	0	8	7
309	R:R:S300	R:R:Y267	2.54	No	Yes	0	7	7
310	R:R:Q303	R:R:Y267	6.76	No	Yes	0	8	7
311	R:R:L270	R:R:L273	5.54	No	No	0	5	6
312	R:R:I292	R:R:L270	4.28	Yes	No	0	5	5
313	R:R:L296	R:R:N271	2.75	No	No	0	4	5
314	R:R:L272	R:R:L276	5.54	No	No	0	5	5
315	R:R:D274	R:R:R278	7.15	Yes	Yes	0	5	4
316	R:R:D274	R:R:I292	4.2	Yes	Yes	0	5	5
317	R:R:L276	R:R:W281	6.83	No	No	0	5	2
318	R:R:I282	R:R:L276	4.28	No	No	0	3	5
319	R:R:D284	R:R:L277	6.79	No	No	0	1	3
320	R:R:L277	R:R:T288	2.95	No	No	0	3	3
321	R:R:I292	R:R:L277	2.85	Yes	No	0	5	3
322	R:R:R279	R:R:W281	2	No	No	0	3	2
323	R:R:D284	R:R:R289	13.1	No	Yes	2	1	3
324	R:R:S285	R:R:T288	6.4	No	No	0	4	3
325	R:R:L291	R:R:Y287	7.03	No	No	0	4	2
326	R:R:G290	R:R:N293	3.39	No	Yes	0	3	4
327	R:R:I292	R:R:L296	2.85	Yes	No	0	5	4
328	R:R:G295	R:R:V298	1.84	No	No	0	6	6
329	R:R:V310	R:R:Y306	6.31	Yes	Yes	1	9	9
330	R:R:I313	R:R:V309	4.61	No	No	0	8	6
331	R:R:P311	R:R:V310	3.53	Yes	Yes	1	9	9
332	R:R:V310	R:R:Y314	2.52	Yes	Yes	0	9	9
333	R:R:F321	R:R:S315	11.89	Yes	No	0	8	7
334	R:R:L320	R:R:R324	4.86	No	No	0	6	5
335	R:R:M325	R:R:Y326	5.99	No	No	0	5	4
336	R:R:Q334	R:R:S335	5.78	No	No	0	6	4
337	L:L:C51	R:R:S37	1.72	No	No	0	0	4
338	L:L:C51	R:R:V38	1.71	No	Yes	0	0	4
339	R:R:G64	R:R:L63	1.71	No	No	0	8	3
340	R:R:G64	R:R:L67	1.71	No	No	0	8	7
341	R:R:G64	R:R:L312	1.71	No	No	0	8	6
342	R:R:G161	R:R:L160	1.71	No	No	0	7	3
343	R:R:G295	R:R:L270	1.71	No	No	0	6	5
344	R:R:A81	R:R:V142	1.7	No	No	0	7	9
345	R:R:A308	R:R:V309	1.7	No	No	0	7	6
346	R:R:C73	R:R:T69	1.69	No	No	0	2	6
347	R:R:A218	R:R:T217	1.68	No	No	0	4	4
348	L:L:G17	L:L:Q16	1.64	No	No	0	0	0
349	R:R:L222	R:R:P223	1.64	No	Yes	0	6	9
350	R:R:G327	R:R:Q330	1.64	No	No	0	4	5
351	L:L:A55	L:L:I58	1.62	No	No	0	0	0
352	R:R:A200	R:R:M203	1.61	No	No	0	5	3
353	L:L:V26	L:L:V40	1.6	No	No	0	0	0
354	R:R:V294	R:R:V45	1.6	No	Yes	0	3	4
355	R:R:S184	R:R:T115	1.6	No	No	0	4	3
356	R:R:V294	R:R:V298	1.6	No	No	0	3	6
357	R:R:T217	R:R:V216	1.59	No	No	0	4	5
358	R:R:T241	R:R:V238	1.59	No	No	0	6	8
359	R:R:C316	R:R:L312	1.59	No	No	0	7	6
360	L:L:A50	L:L:L44	1.58	No	Yes	0	0	0
361	R:R:A304	R:R:L54	1.58	No	No	0	7	7
362	R:R:A172	R:R:L127	1.58	No	Yes	0	7	5
363	R:R:I60	R:R:V309	1.54	No	No	0	5	6
364	R:R:A79	R:R:D83	1.54	No	No	0	5	7
365	R:R:A205	R:R:D206	1.54	No	No	0	1	1
366	R:R:I228	R:R:V257	1.54	No	No	0	4	7
367	L:L:H19	L:L:P20	1.53	Yes	No	0	0	0
368	L:L:C35	L:L:Q37	1.53	No	No	0	0	0
369	R:R:K157	R:R:S159	1.53	No	No	0	6	4
370	R:R:L117	R:R:S114	1.5	Yes	No	0	5	7
371	R:R:N18	R:R:S16	1.49	No	No	0	9	8
372	R:R:N31	R:R:S33	1.49	No	No	0	6	6
373	R:R:L34	R:R:V36	1.49	No	No	0	2	3
374	R:R:L146	R:R:V142	1.49	No	No	0	7	9
375	R:R:L170	R:R:V174	1.49	No	No	0	3	3
376	R:R:L317	R:R:V252	1.49	No	No	0	6	6
377	R:R:L317	R:R:V256	1.49	No	No	0	6	7
378	L:L:S30	R:R:D5	1.47	No	No	0	0	6
379	R:R:L85	R:R:T165	1.47	No	No	0	6	6
380	R:R:I71	R:R:M325	1.46	No	No	0	6	5
381	R:R:F109	R:R:P110	1.44	No	No	0	4	4
382	R:R:Q323	R:R:S319	1.44	No	No	0	4	5
383	R:R:I60	R:R:L56	1.43	No	No	0	5	5
384	R:R:C316	R:R:F321	1.4	No	Yes	0	7	8
385	R:R:L91	R:R:L94	1.38	No	No	0	5	7
386	R:R:L131	R:R:L169	1.38	No	No	0	7	9
387	R:R:E40	R:R:M41	1.35	No	No	0	4	2
388	R:R:E35	R:R:L34	1.33	No	No	0	3	2
389	R:R:L320	R:R:Q323	1.33	No	No	0	6	4
390	L:L:R48	R:R:S33	1.32	No	No	0	0	6
391	R:R:R322	R:R:S319	1.32	No	No	0	8	5
392	R:R:E19	R:R:N18	1.31	Yes	No	0	8	9
393	R:R:F263	R:R:V262	1.31	Yes	No	0	8	4
394	R:R:R119	R:R:T115	1.29	No	No	0	8	3
395	R:R:S285	R:R:Y287	1.27	No	No	0	4	2
396	R:R:K242	R:R:R246	1.24	No	No	0	4	7
397	L:L:L44	L:L:R48	1.21	Yes	No	0	0	0
398	R:R:K157	R:R:W154	1.16	No	No	0	6	5
399	R:R:R247	R:R:R250	1.07	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E6	4.878	5	2	0
2	L:L:R8	8.8225	4	2	0
3	L:L:Q10	4.1725	4	5	0
4	L:L:H19	6.13833	6	6	0
5	L:L:P33	3.5575	4	0	0
6	L:L:L44	2.2725	4	6	0
7	L:L:K49	5.405	4	5	0
8	R:R:L11	4.995	4	3	6
9	R:R:W17	6.015	6	3	5
10	R:R:E19	4.79	4	3	8
11	R:R:L21	6.2675	4	3	5
12	R:R:F32	4.51	4	6	3
13	R:R:V38	3.7975	4	5	4
14	R:R:V45	3.08	5	11	4
15	R:R:F58	5.058	5	0	7
16	R:R:N61	4.9725	4	0	9
17	R:R:I84	6.455	4	13	6
18	R:R:M106	4.0575	4	4	6
19	R:R:L117	3.33	4	4	5
20	R:R:F123	4.4475	4	7	5
21	R:R:Y125	3.775	6	9	6
22	R:R:Y126	2.7075	4	0	5
23	R:R:L127	3.6975	4	0	5
24	R:R:R143	5.42	4	0	9
25	R:R:Y144	4.91	4	0	8
26	R:R:S176	3.215	4	7	7
27	R:R:R183	8.01	5	4	6
28	R:R:D188	6.72	4	0	1
29	R:R:Y197	4.07333	6	2	4
30	R:R:W207	11.24	5	8	4
31	R:R:R208	5.1125	4	2	4
32	R:R:R212	6.575	4	0	5
33	R:R:F220	4.88714	7	1	9
34	R:R:P223	2.715	4	0	9
35	R:R:F230	4.67	4	0	8
36	R:R:Y231	6.524	5	14	9
37	R:R:W235	5.7825	4	0	5
38	R:R:F260	3.672	5	1	9
39	R:R:F263	4.475	4	0	8
40	R:R:Y267	5.8975	4	0	7
41	R:R:D274	5.5175	4	0	5
42	R:R:R278	4.2325	4	2	4
43	R:R:R289	10.045	4	2	3
44	R:R:I292	3.545	4	0	5
45	R:R:N293	5.325	4	2	4
46	R:R:Y306	6.4525	4	1	9
47	R:R:V310	3.8575	4	1	9
48	R:R:P311	3.482	5	1	9
49	R:R:Y314	5.592	5	0	9
50	R:R:F321	6.175	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y125	R:R:Y126	21.4713	1.99	Yes	Yes	0	6	5
2	R:R:I122	R:R:Y126	17.985	3.63	No	Yes	0	6	5
3	R:R:I122	R:R:R183	17.8759	13.78	No	Yes	0	6	6
4	R:R:S300	R:R:Y125	21.1116	2.54	No	Yes	9	7	6
5	R:R:S300	R:R:Y267	22.597	2.54	No	Yes	0	7	7
6	R:R:N271	R:R:Y267	82.5808	9.3	No	Yes	0	5	7
7	R:R:L296	R:R:N271	16.926	2.75	No	No	0	4	5
8	R:R:I292	R:R:L296	10.5618	2.85	Yes	No	0	5	4
9	R:R:I292	R:R:L270	10.5234	4.28	Yes	No	0	5	5
10	R:R:E198	R:R:R183	14.8605	13.96	No	Yes	0	5	6
11	R:R:E198	R:R:Y197	15.576	2.24	No	Yes	0	5	4
12	R:R:N271	R:R:R212	65.5538	13.26	No	Yes	0	5	5
13	R:R:R208	R:R:R212	60.2991	3.2	Yes	Yes	0	4	5
14	R:R:R278	R:R:Y197	11.8775	3.09	Yes	Yes	2	4	4
15	L:L:L7	R:R:Y197	69.9171	5.86	No	Yes	0	0	4
16	L:L:H34	L:L:L7	69.4179	2.57	No	No	0	0	0
17	L:L:H34	R:R:P189	71.7098	18.3	No	No	0	0	2
18	R:R:D188	R:R:P189	71.1641	8.05	Yes	No	0	1	2
19	R:R:D188	R:R:V190	68.941	5.84	Yes	No	0	1	1
20	L:L:Q10	R:R:V190	68.3751	2.87	Yes	No	0	0	1
21	L:L:Q10	R:R:V38	61.1924	4.3	Yes	Yes	5	0	4
22	L:L:C51	R:R:V38	56.4733	1.71	No	Yes	0	0	4
23	L:L:C51	R:R:S37	51.9887	1.72	No	No	0	0	4
24	L:L:Q13	R:R:S37	51.3319	10.11	No	No	0	0	4
25	L:L:L15	L:L:Q13	50.671	7.99	No	No	0	0	0
26	L:L:L15	R:R:F32	50.0061	3.65	No	Yes	0	0	3
27	R:R:F32	R:R:Y28	23.3589	5.16	Yes	No	6	3	7
28	R:R:S29	R:R:Y28	24.4766	2.54	No	No	0	6	7
29	L:L:G17	R:R:S29	22.8314	1.86	No	No	0	0	6
30	L:L:G17	L:L:Q16	22.0028	1.64	No	No	0	0	0
31	L:L:N53	L:L:Q16	21.1702	10.56	No	No	0	0	0
32	L:L:I58	L:L:N53	18.6479	4.25	No	No	0	0	0
33	L:L:I58	L:L:V59	13.4943	3.07	No	No	0	0	0
34	L:L:L52	L:L:V59	12.6213	4.47	No	No	0	0	0
35	L:L:H19	R:R:F32	22.2939	6.79	Yes	Yes	6	0	3
36	L:L:H19	L:L:I23	20.9519	2.65	Yes	No	0	0	0
37	L:L:I23	R:R:L11	20.1253	4.28	No	Yes	0	0	6
38	L:L:L52	L:L:V40	10.8589	4.47	No	No	0	0	0
39	R:R:V186	R:R:Y197	12.7809	2.52	No	Yes	0	1	4
40	L:L:P33	R:R:V186	12.116	3.53	Yes	No	0	0	1
41	L:L:P33	R:R:T204	10.0465	1.75	Yes	No	0	0	3
42	R:R:T299	R:R:Y267	100	4.99	No	Yes	0	8	7
43	R:R:P266	R:R:T299	99.9879	1.75	No	No	0	9	8
44	R:R:F265	R:R:P266	99.9717	2.89	No	No	0	5	9
45	R:R:F220	R:R:F265	99.0299	6.43	Yes	No	1	9	5
46	R:R:F220	R:R:F260	59.1249	3.22	Yes	Yes	1	9	9
47	R:R:F260	R:R:I133	21.0287	2.51	Yes	No	0	9	8
48	R:R:F260	R:R:Y306	40.7356	6.19	Yes	Yes	1	9	9
49	R:R:V310	R:R:Y306	76.2631	6.31	Yes	Yes	1	9	9
50	R:R:P311	R:R:V310	37.7627	3.53	Yes	Yes	1	9	9
51	R:R:N65	R:R:P311	14.2724	3.26	No	Yes	1	9	9
52	R:R:N61	R:R:N65	14.5958	9.54	Yes	No	0	9	9
53	R:R:C264	R:R:F220	39.5655	2.79	No	Yes	1	9	9
54	R:R:C264	R:R:Y306	39.2947	4.03	No	Yes	1	9	9
55	R:R:V310	R:R:Y314	49.1977	2.52	Yes	Yes	0	9	9
56	R:R:R143	R:R:Y314	39.5412	3.09	Yes	Yes	0	9	9
57	R:R:I82	R:R:R143	26.1419	2.51	No	Yes	0	8	9
58	R:R:I82	R:R:V142	24.996	6.14	No	No	0	8	9
59	R:R:A81	R:R:V142	15.6831	1.7	No	No	0	7	9
60	R:R:A81	R:R:G161	14.5008	1.95	No	No	0	7	7
61	R:R:G161	R:R:I84	12.1241	3.53	No	Yes	0	7	6
62	R:R:P311	R:R:V68	24.4705	1.77	Yes	No	1	9	9
63	R:R:F321	R:R:V68	24.6665	2.62	Yes	No	0	8	9
64	R:R:F321	R:R:I71	15.7619	8.79	Yes	No	0	8	6
65	R:R:I71	R:R:R324	11.8755	6.26	No	No	0	6	5
66	R:R:S176	R:R:Y126	12.0049	2.54	Yes	Yes	0	7	5
67	R:R:C196	R:R:R183	13.3367	5.57	No	Yes	4	9	6
68	R:R:C196	R:R:M106	12.504	3.24	No	Yes	4	9	6
69	R:R:I133	R:R:P223	12.8153	3.39	No	Yes	0	8	9
70	R:R:P223	R:R:V137	11.1176	1.77	Yes	No	0	9	7
71	R:R:L226	R:R:V137	10.6245	4.47	No	No	0	6	7
72	R:R:F230	R:R:L226	10.2466	2.44	Yes	No	0	8	6
73	R:R:R208	R:R:Y197	63.4903	8.23	Yes	Yes	2	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:A1	R:R:E121	3.02	0	No	No	0	5	0	1
L:L:A1	R:R:Y125	8.01	0	No	Yes	0	6	0	1
L:L:S2	R:R:R183	3.95	0	No	Yes	0	6	0	1
L:L:V3	R:R:Y125	2.52	9	No	Yes	0	6	0	1
L:L:V3	R:R:S300	3.23	9	No	No	0	7	0	1
L:L:A4	R:R:A297	1.79	0	No	No	0	5	0	1
L:L:T5	R:R:Y197	2.5	0	No	Yes	0	4	0	1
L:L:E6	R:R:R208	5.82	2	Yes	Yes	0	4	0	1
L:L:E6	R:R:R278	3.49	2	Yes	Yes	0	4	0	1
L:L:E6	R:R:N293	2.63	2	Yes	Yes	0	4	0	1
L:L:E6	R:R:L296	6.63	2	Yes	No	0	4	0	1
L:L:L7	R:R:Y197	5.86	0	No	Yes	0	4	0	1
L:L:R8	R:R:D274	4.76	2	Yes	Yes	0	5	0	1
L:L:R8	R:R:R289	13.86	2	Yes	Yes	0	3	0	1
L:L:R8	R:R:N293	10.85	2	Yes	Yes	0	4	0	1
L:L:Q10	R:R:V38	4.3	5	Yes	Yes	0	4	0	1
L:L:Q10	R:R:V190	2.87	5	Yes	No	0	1	0	1
L:L:L12	R:R:D284	6.79	2	No	No	0	1	0	1
L:L:L12	R:R:R289	4.86	2	No	Yes	0	3	0	1
L:L:Q13	R:R:S37	10.11	0	No	No	0	4	0	1
L:L:L15	R:R:F32	3.65	0	No	Yes	0	3	0	1
L:L:G17	R:R:S29	1.86	0	No	No	0	6	0	1
L:L:H19	R:R:Y28	13.07	6	Yes	No	0	7	0	1
L:L:H19	R:R:F32	6.79	6	Yes	Yes	0	3	0	1
L:L:P20	R:R:G25	2.03	0	No	No	0	2	0	1
L:L:K21	R:R:D13	11.06	3	No	No	0	6	0	1
L:L:K21	R:R:W17	3.48	3	No	Yes	0	5	0	1
L:L:I23	R:R:L11	4.28	0	No	Yes	0	6	0	1
L:L:N27	R:R:F6	2.42	0	No	No	0	6	0	1
L:L:N27	R:R:T8	10.24	0	No	No	0	6	0	1
L:L:V28	R:R:T8	6.35	0	No	No	0	6	0	1
L:L:S30	R:R:F6	2.64	0	No	No	0	6	0	1
L:L:P33	R:R:V186	3.53	0	Yes	No	0	1	0	1
L:L:P33	R:R:N199	4.89	0	Yes	No	0	4	0	1
L:L:P33	R:R:T204	1.75	0	Yes	No	0	3	0	1
L:L:H34	R:R:P189	18.3	0	No	No	0	2	0	1
L:L:I41	R:R:V38	6.14	5	No	Yes	0	4	0	1
L:L:L44	R:R:F32	2.44	6	Yes	Yes	0	3	0	1
L:L:K49	R:R:V38	3.04	5	Yes	Yes	0	4	0	1
L:L:K49	R:R:E40	6.75	5	Yes	No	0	4	0	1
L:L:K61	R:R:Y26	5.97	3	No	No	0	3	0	1
L:L:I62	R:R:L21	4.28	3	No	Yes	0	5	0	1
L:L:I62	R:R:Y26	6.04	3	No	No	0	3	0	1
R:R:F6	R:R:K192	3.72	0	No	No	6	5	1	2
R:R:D13	R:R:L11	6.79	3	No	Yes	6	6	1	1
R:R:L11	R:R:W17	2.28	3	Yes	Yes	6	5	1	1
R:R:E19	R:R:L11	6.63	3	Yes	Yes	8	6	2	1
R:R:D13	R:R:W17	8.93	3	No	Yes	6	5	1	1
R:R:E19	R:R:W17	3.27	3	Yes	Yes	8	5	2	1
R:R:L21	R:R:W17	6.83	3	Yes	Yes	5	5	1	1
R:R:N22	R:R:W17	11.3	0	No	Yes	5	5	2	1
R:R:E19	R:R:L21	7.95	3	Yes	Yes	8	5	2	1
R:R:L21	R:R:S24	6.01	3	Yes	No	5	8	1	2
R:R:S24	R:R:Y26	11.45	0	No	No	8	3	2	1
R:R:S29	R:R:Y28	2.54	0	No	No	6	7	1	1
R:R:F32	R:R:Y28	5.16	6	Yes	No	3	7	1	1
R:R:G30	R:R:S29	1.86	0	No	No	4	6	2	1
R:R:C39	R:R:R289	8.36	0	No	Yes	8	3	2	1
R:R:N293	R:R:V44	4.43	2	Yes	No	4	4	1	2
R:R:A297	R:R:V45	3.39	0	No	Yes	5	4	1	2
R:R:S99	R:R:Y125	2.54	0	No	Yes	7	6	2	1
R:R:E103	R:R:E121	8.88	12	No	No	6	5	2	1
R:R:C118	R:R:R183	2.79	4	No	Yes	9	6	2	1
R:R:C118	R:R:C196	7.28	4	No	No	9	9	2	2
R:R:I122	R:R:Y126	3.63	0	No	Yes	6	5	2	2
R:R:I122	R:R:R183	13.78	0	No	Yes	6	6	2	1
R:R:Y125	R:R:Y126	1.99	9	Yes	Yes	6	5	1	2
R:R:V129	R:R:Y125	5.05	0	No	Yes	7	6	2	1
R:R:S300	R:R:Y125	2.54	9	No	Yes	7	6	1	1
R:R:C196	R:R:R183	5.57	4	No	Yes	9	6	2	1
R:R:E198	R:R:R183	13.96	0	No	Yes	5	6	2	1
R:R:N199	R:R:S184	5.96	0	No	No	4	4	1	2
R:R:V186	R:R:Y197	2.52	0	No	Yes	1	4	1	1
R:R:D188	R:R:P189	8.05	0	Yes	No	1	2	2	1
R:R:D188	R:R:V190	5.84	0	Yes	No	1	1	2	1
R:R:E198	R:R:Y197	2.24	0	No	Yes	5	4	2	1
R:R:R208	R:R:Y197	8.23	2	Yes	Yes	4	4	1	1
R:R:R278	R:R:Y197	3.09	2	Yes	Yes	4	4	1	1
R:R:A200	R:R:T204	3.36	0	No	No	5	3	2	1
R:R:R208	R:R:R212	3.2	2	Yes	Yes	4	5	1	2
R:R:R208	R:R:R278	3.2	2	Yes	Yes	4	4	1	1
R:R:N271	R:R:R212	13.26	0	No	Yes	5	5	2	2
R:R:D274	R:R:R212	5.96	0	Yes	Yes	5	5	1	2
R:R:N271	R:R:Y267	9.3	0	No	Yes	5	7	2	2
R:R:S300	R:R:Y267	2.54	9	No	Yes	7	7	1	2
R:R:L296	R:R:N271	2.75	0	No	No	4	5	1	2
R:R:D274	R:R:R278	7.15	0	Yes	Yes	5	4	1	1
R:R:D274	R:R:I292	4.2	0	Yes	Yes	5	5	1	2
R:R:D284	R:R:L277	6.79	2	No	No	1	3	1	2
R:R:I292	R:R:L277	2.85	0	Yes	No	5	3	2	2
R:R:D284	R:R:R289	13.1	2	No	Yes	1	3	1	1
R:R:G290	R:R:N293	3.39	0	No	Yes	3	4	2	1
R:R:I292	R:R:L296	2.85	0	Yes	No	5	4	2	1
L:L:C51	R:R:S37	1.72	0	No	No	0	4	0	1
L:L:C51	R:R:V38	1.71	0	No	Yes	0	4	0	1
R:R:N31	R:R:S33	1.49	0	No	No	6	6	2	1
L:L:S30	R:R:D5	1.47	0	No	No	0	6	0	1
R:R:E40	R:R:M41	1.35	0	No	No	4	2	1	2
L:L:R48	R:R:S33	1.32	0	No	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8K4O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.75
Number of Linked Nodes	362
Number of Links	399
Number of Hubs	50
Number of Links mediated by Hubs	183
Number of Communities	14
Number of Nodes involved in Communities	74
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	89000
Length Of Smallest Path	3
Average Path Length	19.8316
Length of Longest Path	51
Minimum Path Strength	1.265
Average Path Strength	5.09498
Maximum Path Strength	16.925
Minimum Path Correlation	0.7
Average Path Correlation	0.956172
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	58.0747
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7324
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • enzyme activator activity • molecular function activator activity • signaling receptor activator activity • cytokine receptor binding • chemokine activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • growth factor activity • chemotaxis • taxis • response to external stimulus • locomotion • immune response • negative regulation of cell population proliferation • regulation of cell population proliferation • nervous system development • defense response • response to stress • inflammatory response • actin cytoskeleton organization • actin filament-based process • tertiary granule lumen • intracellular vesicle • tertiary granule • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen • specific granule lumen • specific granule • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • positive regulation of cytosolic calcium ion concentration • cell chemotaxis • calcium-mediated signaling • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q76SF8
Sequence	>8K4O_nogp_Chain_R D F L T I F L D D D E S W N E T L N M S G Y D Y S G N F S L E V S V C E M T T V V P Y T W N V G I L S L I F L I N V L G N G L V T Y I F C K H R S R A G A I D I L L L G I C L N S L C L S I S L L A E V L M F L F P N I I S T G L C R L E I F F Y Y L Y V Y L D I F S V V C V S L V R Y L L V A Y S T R S W P K K Q S L G W V L T S A A L L I A L V L S G D A C R H R S R V V D P V S K Q A M C Y E N A G N M T A D W R L H V R T V S V T A G F L L P L A L L I L F Y A L T W C V V R R T K L Q A R R K V R G V I V A V V L L F F V F C F P Y H V L N L L D T L L R R R W I R D S C Y T R G L I N V G L A V T S L L Q A L Y S A V V P L I Y S C L G S L F R Q R M Y G L F Q S L R Q S F M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8K4O	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	CXCL1	-	Gi1/β1/γ1	3.01	2024-07-24	doi.org/10.1073/pnas.2403217121
	8K4O (No Gprot)	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	CXCL1	-		3.01	2024-07-24	doi.org/10.1073/pnas.2403217121
	8K4P	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	-	-	Gi1/β1/γ1	2.81	2024-07-24	doi.org/10.1073/pnas.2403217121
	8K4P (No Gprot)	A	Other	Unclassified	KSHV	Human gammaherpesvirus 8	-	-		2.81	2024-07-24	doi.org/10.1073/pnas.2403217121

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8K4O_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.